calmodulin

Summary

Gene Symbol: calmodulin
Description: calmodulin 1
Alias: CALML2, CAMI, CPVT4, DD132, LQT14, PHKD, caM, calmodulin, calmodulin 1 (phosphorylase kinase, delta), phosphorylase kinase subunit delta, phosphorylase kinase, delta subunit, prepro-calmodulin 1
Species: human

Top Publications

  1. ncbi Identification of a calmodulin-binding and inhibitory peptide domain in the HIV-1 transmembrane glycoprotein
    M A Miller
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261
    AIDS Res Hum Retroviruses 9:1057-66. 1993
  2. ncbi Community knowledge of mental illness and reaction to mentally ill people
    G Wolff
    MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London
    Br J Psychiatry 168:191-8. 1996
  3. ncbi Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALM3
    S L Toutenhoofd
    Department of Biochemistry and Molecular Biology, Mayo Graduate School, Mayo Foundation, Rochester, MN 55905, USA
    Cell Calcium 23:323-38. 1998
  4. doi Attitudes towards mental illness in Sweden: adaptation and development of the Community Attitudes towards Mental Illness questionnaire
    Torbjörn Högberg
    Division of Psychiatry, Institution of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Int J Ment Health Nurs 17:302-10. 2008
  5. pmc (-)-epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways
    Israel Ramirez-Sanchez
    Department of Medicine, University of California, San Diego, Calif, USA
    Hypertension 55:1398-405. 2010
  6. ncbi Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity
    I Fleming
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, Frankfurt, Germany
    Circ Res 88:E68-75. 2001
  7. ncbi The dynamic alterations of H2AX complex during DNA repair detected by a proteomic approach reveal the critical roles of Ca(2+)/calmodulin in the ionizing radiation-induced cell cycle arrest
    Yu Chun Du
    Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
    Mol Cell Proteomics 5:1033-44. 2006
  8. pmc Structural and energetic determinants of apo calmodulin binding to the IQ motif of the Na(V)1.2 voltage-dependent sodium channel
    Michael D Feldkamp
    Department of Biochemistry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1109, USA
    Structure 19:733-47. 2011
  9. ncbi HIV-1 Nef upregulates CCL2/MCP-1 expression in astrocytes in a myristoylation- and calmodulin-dependent manner
    Michael H Lehmann
    Institute of Molecular Virology, GSF National Research Center for Environment and Health, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    J Cell Sci 119:4520-30. 2006
  10. pmc Inhibition of human ether à go-go potassium channels by Ca(2+)/calmodulin
    R Schönherr
    Arbeitsgruppe Molekulare und Zelluläre Biophysik, am Klinikum der Friedrich Schiller Universität Jena, Drackendorfer Strabetae 1, D 07747 Jena, Germany
    EMBO J 19:3263-71. 2000

Research Grants

Detail Information

Publications221 found, 100 shown here

  1. ncbi Identification of a calmodulin-binding and inhibitory peptide domain in the HIV-1 transmembrane glycoprotein
    M A Miller
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261
    AIDS Res Hum Retroviruses 9:1057-66. 1993
    ..that displays functional properties of target regions of proteins that interact directly with calcium-saturated calmodulin as part of cellular response cascades...
  2. ncbi Community knowledge of mental illness and reaction to mentally ill people
    G Wolff
    MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London
    Br J Psychiatry 168:191-8. 1996
    ..We test the hypothesis that negative attitudes to mentally ill people may be fuelled by a lack of knowledge...
  3. ncbi Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALM3
    S L Toutenhoofd
    Department of Biochemistry and Molecular Biology, Mayo Graduate School, Mayo Foundation, Rochester, MN 55905, USA
    Cell Calcium 23:323-38. 1998
    Human calmodulin is encoded by three genes CALM1, CALM2 and CALM3 located on different chromosomes...
  4. doi Attitudes towards mental illness in Sweden: adaptation and development of the Community Attitudes towards Mental Illness questionnaire
    Torbjörn Högberg
    Division of Psychiatry, Institution of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Int J Ment Health Nurs 17:302-10. 2008
    ..study, conducted in Sweden, was to evaluate an existing instrument's (Community Attitudes towards Mental Illness, CAMI), validity and reliability. An additional aim was to adapt and develop the questionnaire to Swedish circumstances...
  5. pmc (-)-epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways
    Israel Ramirez-Sanchez
    Department of Medicine, University of California, San Diego, Calif, USA
    Hypertension 55:1398-405. 2010
    ..Epicatechin induces eNOS uncoupling from caveolin-1 and its association with calmodulin-1, suggesting the involvement of intracellular calcium...
  6. ncbi Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity
    I Fleming
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, Frankfurt, Germany
    Circ Res 88:E68-75. 2001
    ..high-output) activation of eNOS is associated with changes in the phosphorylation of Thr(495) in the calmodulin (CaM)-binding domain...
  7. ncbi The dynamic alterations of H2AX complex during DNA repair detected by a proteomic approach reveal the critical roles of Ca(2+)/calmodulin in the ionizing radiation-induced cell cycle arrest
    Yu Chun Du
    Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
    Mol Cell Proteomics 5:1033-44. 2006
    ..In the non-irradiated control cells, calmodulin (CaM) and the transcription elongation factor facilitates chromatin transcription (FACT) were associated with ..
  8. pmc Structural and energetic determinants of apo calmodulin binding to the IQ motif of the Na(V)1.2 voltage-dependent sodium channel
    Michael D Feldkamp
    Department of Biochemistry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1109, USA
    Structure 19:733-47. 2011
    ..2), essential for generation and propagation of action potentials, is regulated by calmodulin (CaM) binding to the IQ motif in its α subunit. A peptide (Na(v)1...
  9. ncbi HIV-1 Nef upregulates CCL2/MCP-1 expression in astrocytes in a myristoylation- and calmodulin-dependent manner
    Michael H Lehmann
    Institute of Molecular Virology, GSF National Research Center for Environment and Health, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    J Cell Sci 119:4520-30. 2006
    ..that Nef-induced CCL2/MCP-1 expression depends on the myristoylation moiety of Nef and requires functional calmodulin. In summary, we suggest that Nef-induced CCL2/MCP-1 expression in astrocytes contributes to infiltration of ..
  10. pmc Inhibition of human ether à go-go potassium channels by Ca(2+)/calmodulin
    R Schönherr
    Arbeitsgruppe Molekulare und Zelluläre Biophysik, am Klinikum der Friedrich Schiller Universität Jena, Drackendorfer Strabetae 1, D 07747 Jena, Germany
    EMBO J 19:3263-71. 2000
    ..However, Ca(2+) sensitivity could be restored by application of recombinant calmodulin (CaM). In the presence of CaM, half inhibition of hEAG1 channels was obtained in 100 nM Ca(2+)...
  11. pmc WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A
    C S Moreno
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 275:5257-63. 2000
    ..We have identified two calmodulin (CaM)-binding proteins that form stable complexes with the PP2A A/C heterodimer and may represent a novel family ..
  12. ncbi Ca(2+)-dependent and Ca(2+)-independent calmodulin binding sites in erythrocyte protein 4.1. Implications for regulation of protein 4.1 interactions with transmembrane proteins
    W Nunomura
    Department of Biochemistry, School of Medicine, Tokyo Women s Medical University, Shinjuku, Tokyo 162 8666, Japan
    J Biol Chem 275:6360-7. 2000
    In vitro protein binding assays identified two distinct calmodulin (CaM) binding sites within the NH(2)-terminal 30-kDa domain of erythrocyte protein 4.1 (4...
  13. ncbi Rab3B in human platelet is membrane bound and interacts with Ca(2+)/calmodulin
    R S Sidhu
    Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, R3E 0W2, Canada
    Biochem Biophys Res Commun 289:1039-43. 2001
    ..Using GST-Rab3B in in vitro pull-down experiments, the binding of calmodulin from platelet cytosol to Rab3B was demonstrated...
  14. ncbi Calmodulin regulates transglutaminase 2 cross-linking of huntingtin
    Gina M Zainelli
    Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Neurosci 24:1954-61. 2004
    ..Because calmodulin regulates transglutaminase activity in erythrocytes, platelets, and the gizzard, we hypothesized that calmodulin ..
  15. ncbi Mechanism of 2-chloro-(epsilon-amino-Lys75)-[6-[4-(N,N- diethylamino)phenyl]-1,3,5-triazin-4-yl]calmodulin interactions with smooth muscle myosin light chain kinase and derived peptides
    K Torok
    National Institute for Medical Research, Mill Hill, London, United Kingdom
    Biochemistry 33:12807-20. 1994
    ..of the interactions of 2-chloro-(epsilon-amino-Lys75)-[6-[4-(N,N-diethylamino)phenyl]- 1,3,5-triazin-4-yl]calmodulin (TA-calmodulin) with smooth muscle myosin light-chain kinase (MLCK) and two 17-residue peptides, Ac-R-R-K-W-Q-K-..
  16. pmc Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway
    E Brigino
    Department of Pediatrics, University of South Florida, St Petersburg 33701, USA
    Proc Natl Acad Sci U S A 94:3178-82. 1997
    ..IL-10 protein production induced by Nef is inhibited by the calcium/calmodulin phosphodiesterase inhibitor W-7 but not by the protein kinase A inhibitor H-89 nor the protein kinase C ..
  17. pmc Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with calmodulin
    B Martoglio
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, Postfach 106249, 69052 Heidelberg, Germany
    EMBO J 16:6636-45. 1997
    ..This signal peptide fragment was found to interact efficiently with calmodulin. Similar to preprolactin, the signal sequence of the HIV-1 envelope protein p-gp160 has the characteristic ..
  18. ncbi Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex
    W E Meador
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030
    Science 257:1251-5. 1992
    The crystal structure of calcium-bound calmodulin (Ca(2+)-CaM) bound to a peptide analog of the CaM-binding region of chicken smooth muscle myosin light chain kinase has been determined and refined to a resolution of 2.4 angstroms (A)...
  19. ncbi Regulation of p68 RNA helicase by calmodulin and protein kinase C
    M K Buelt
    Department of Pharmacology, University of Washington, Seattle 98195
    J Biol Chem 269:29367-70. 1994
    ..that p68 possesses a region of sequence similarity to the conserved protein kinase C phosphorylation site and calmodulin binding domain (also known as the IQ domain) of the neural-specific proteins neuromodulin (GAP-43) and ..
  20. ncbi Cytosolic domain of the human immunodeficiency virus envelope glycoproteins binds to calmodulin and inhibits calmodulin-regulated proteins
    S K Srinivas
    Department of Medicine, University of Alabama at Birmingham 35294
    J Biol Chem 268:22895-9. 1993
    b>Calmodulin (CaM), the major intracellular receptor for calcium, is involved in regulation of diverse cellular functions...
  21. ncbi Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3
    M W Berchtold
    Institute of Veterinary Biochemistry, University of Zurich Irchel, Switzerland
    Genomics 16:461-5. 1993
    The three bona fide genes coding for calmodulin CALM1, CALM2, and CALM3, were assigned to human chromosomes 14, 2, and 19, respectively, by polymerase chain reaction-based amplification of calmodulin gene-specific sequences using DNA from ..
  22. ncbi Expression of HIV-1 envelope glycoprotein alters cellular calmodulin
    W Radding
    Department of Pathology, University of Alabama at Birmingham 35294 0007, USA
    Biochem Biophys Res Commun 218:192-7. 1996
    Removal of parts of a known calmodulin binding site at the C-terminus of HIV-1 envelope glycoprotein, gp160, can result in diminished infectivity...
  23. pmc IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs
    M J Hart
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    EMBO J 15:2997-3005. 1996
    ..Cdc42 was also co-immunoprecipitated from cell lysates with antibody specific to p195/IQGAP1. Calmodulin also co-immunoprecipitated with p195/IQGAP1 and was found to associate with fragments containing the IQ domain...
  24. pmc The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases
    S Brill
    Massachusetts General Hospital Cancer Centre, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Mol Cell Biol 16:4869-78. 1996
    ..pombe sar1 RasGAP homolog. As predicted by the presence of IQ motifs, IQGAP2 binds calmodulin. However, neither full-length nor truncated IQGAP2 stimulated the GTPase activity of Ras or its close relatives...
  25. pmc Role of calmodulin in HIV-potentiated Fas-mediated apoptosis
    Z Pan
    Department of Pathology, University of Alabama at Birmingham 35294 0007, USA
    Am J Pathol 149:903-10. 1996
    ..Many apoptotic pathways depend on calcium and therefore would be expected to involve calmodulin. As the HIV-1 envelope glycoprotein, gp160, contains two known calmodulin-binding domains, we investigated the ..
  26. ncbi Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro
    R Minakami
    School of Health Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 82, Japan
    J Biol Chem 272:20291-8. 1997
    ..We herein report that calmodulin (CaM) interacts with the metabotropic glutamate receptor subtype 5 (mGluR5) in a Ca2+-dependent manner in vitro...
  27. pmc Apoptosis induction by the binding of the carboxyl terminus of human immunodeficiency virus type 1 gp160 to calmodulin
    H Ishikawa
    Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    J Virol 72:6574-80. 1998
    The role of calmodulin (CaM) in apoptosis induced by gp160 of human immunodeficiency virus type 1 was investigated with cells undergoing single-cell killing...
  28. ncbi A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7
    Y Nakajima
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    J Biol Chem 274:27573-7. 1999
    ..Here, we report that calmodulin (CaM) directly binds to the carboxyl terminus of mGluR7 in a Ca(2+)-dependent manner...
  29. ncbi Requirement of calmodulin binding by HIV-1 gp160 for enhanced FAS-mediated apoptosis
    K J Micoli
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 275:1233-40. 2000
    ..The HIV-1 envelope glycoprotein, gp160, contains two C-terminal calmodulin-binding domains...
  30. ncbi Calmodulin and HIV type 1: interactions with Gag and Gag products
    W Radding
    Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005, USA
    AIDS Res Hum Retroviruses 16:1519-25. 2000
    The level of calmodulin increases in cells expressing HIV-1 envelope glycoprotein...
  31. ncbi Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin
    M A Schumacher
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
    Nature 410:1120-4. 2001
    ..channels are heteromeric complexes that comprise pore-forming alpha-subunits and the Ca2+-binding protein calmodulin (CaM)...
  32. ncbi Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1
    Zhigang Li
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:4347-52. 2003
    b>Calmodulin regulates the function of numerous proteins by binding to short regions on the target molecule. IQ motifs, which are found in over 100 human proteins, appear in tandem repeats and bind calmodulin in the absence of Ca(2+)...
  33. pmc Regulation of c-Rel nuclear localization by binding of Ca2+/calmodulin
    Asa Antonsson
    Department of Molecular Biology, Umea University, 901 87 Umea, Sweden
    Mol Cell Biol 23:1418-27. 2003
    ..b>Calmodulin (CaM) is a highly conserved, ubiquitously expressed Ca(2+) binding protein that serves as a key mediator of ..
  34. ncbi Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca2+-calmodulin
    Emiko Yamauchi
    Harima Institute at SPring 8, RIKEN, 1 1 1 Kouto, Sayo, Hyogo 679 5148, Japan
    Nat Struct Biol 10:226-31. 2003
    The calmodulin-binding domain of myristoylated alanine-rich C kinase substrate (MARCKS), which interacts with various targets including calmodulin, actin and membrane lipids, has been suggested to function as a crosstalk point among ..
  35. pmc Myristoyl moiety of HIV Nef is involved in regulation of the interaction with calmodulin in vivo
    Mamoru Matsubara
    Division of Biomedical Polymer Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Protein Sci 14:494-503. 2005
    ..In the present report, we show that Nef can interact with calmodulin, the major intracellular receptor for calcium...
  36. ncbi A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese
    Hideyuki Mototani
    Laboratory for Bone and Joint Diseases, The Institute of Physical and Chemical Research RIKEN, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Hum Mol Genet 14:1009-17. 2005
    ..8x10(-7)) between hip OA and a SNP (IVS3-293C>T) located in intron 3 of the calmodulin (CaM) 1 gene (CALM1)...
  37. ncbi Defective calmodulin-mediated nuclear transport of the sex-determining region of the Y chromosome (SRY) in XY sex reversal
    Helena Sim
    Prince Henry s Institute of Medical Research, Level 4 Block E, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Mol Endocrinol 19:1884-92. 2005
    ..The SRY N-terminal NLS (n-NLS) binds calmodulin (CaM) in vitro, and here we show that this protein interaction is reduced in vivo by calmidazolium, a CaM ..
  38. ncbi Ca2+ and calmodulin regulate the binding of filamin A to actin filaments
    Fumihiko Nakamura
    Hematology Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:32426-33. 2005
    ..We report that Ca(2+)-calmodulin binds the actin-binding domain (ABD) of FLNa and dissociates FLNa from F-actin, thereby dissolving FLNa...
  39. pmc Point mutations in the C-terminus of HIV-1 gp160 reduce apoptosis and calmodulin binding without affecting viral replication
    Keith J Micoli
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Virology 344:468-79. 2006
    ..Prior studies have shown that binding of cellular calmodulin to the envelope glycoprotein (Env) of HIV-1 increases sensitivity to fas-mediated apoptosis and that calmodulin ..
  40. pmc Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex
    Filip Van Petegem
    Cardiovascular Research Institute, Department of Biochemistry and Biophysics, California Institute for Quantitative Biomedical Research, University of California, San Francisco, 1700 4th St, Box 2532, San Francisco, California 94143 2532, USA
    Nat Struct Mol Biol 12:1108-15. 2005
    ..Ca(V)s) drive two self-regulatory calcium-dependent feedback processes that require interaction between Ca(2+)/calmodulin (Ca(2+)/CaM) and a Ca(V) channel consensus isoleucine-glutamine (IQ) motif: calcium-dependent inactivation (CDI) ..
  41. ncbi Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channel
    Jennifer L Fallon
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Structure 13:1881-6. 2005
    Ca2+-dependent inactivation (CDI) and facilitation (CDF) of the Ca(v)1.2 Ca2+ channel require calmodulin binding to a putative IQ motif in the carboxy-terminal tail of the pore-forming subunit. We present the 1...
  42. ncbi The CALM1 core promoter polymorphism is not associated with hip osteoarthritis in a United Kingdom Caucasian population
    J Loughlin
    Institute of Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, Oxford, UK
    Osteoarthritis Cartilage 14:295-8. 2006
    ..with hip osteoarthritis (OA) of a functional single nucleotide polymorphism (SNP) in the core promoter of the calmodulin 1 gene CALM1 was recently reported in a Japanese population...
  43. ncbi Proteomic and biochemical studies of calcium- and phosphorylation-dependent calmodulin complexes in Mammalian cells
    Deok Jin Jang
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 84 171, Berkeley, California 94720, USA
    J Proteome Res 6:3718-28. 2007
    ..g., phosphorylation) modulate dynamic protein complexes. Calmodulin (CaM) plays an essential role in regulating calcium signaling and homeostasis...
  44. ncbi Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain
    Daniel W Lambert
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
    FEBS Lett 582:385-90. 2008
    ..In this study, we demonstrate that inhibitors of calmodulin also stimulate shedding of the ACE2 ectodomain, a process at least partially mediated by a metalloproteinase...
  45. pmc Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling
    Marilyne Labasque
    Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5203, Institut de Genomique Fonctionnelle, Montpellier F 34094, France
    Mol Biol Cell 19:4640-50. 2008
    ..Here, we show that calmodulin (CaM) binds to a prototypic Ca(2+)-dependent "1-10" CaM-binding motif located in the proximal region of the 5-HT(..
  46. pmc Two synthetic peptides corresponding to the proximal heme-binding domain and CD1 domain of human endothelial nitric-oxide synthase inhibit the oxygenase activity by interacting with CaM
    Pei Feng Chen
    Vascular Biology Research Center, Department of Internal Medicine, The University of Texas Health Science Center at Houston, TX, USA
    Arch Biochem Biophys 486:132-40. 2009
    Human endothelial nitric-oxide synthase (eNOS) is a complex enzyme, requiring binding of calmodulin (CaM) for electron transfer...
  47. doi Molecular basis of the death-associated protein kinase-calcium/calmodulin regulator complex
    Iñaki de Diego
    European Molecular Biology Laboratory Hamburg, Notkestrasse 85, D 22603 Hamburg, Germany
    Sci Signal 3:ra6. 2010
    Death-associated protein kinase (DAPK) provides a model for calcium-bound calmodulin (CaM)-dependent protein kinases (CaMKs)...
  48. pmc Calmodulin disrupts the structure of the HIV-1 MA protein
    John Y H Chow
    School of Molecular Bioscience, University of Sydney, New South Wales 2006, Australia
    J Mol Biol 400:702-14. 2010
    ..interacts with host cell proteins and it has been reported that one of these is the ubiquitous calcium-sensing calmodulin (CaM), which is up-regulated upon HIV-1 infection...
  49. pmc Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization
    Eun Young Kim
    Cardiovascular Research Institute, University of California, San Francisco, CA 94158 2330, USA
    EMBO J 29:3924-38. 2010
    Interactions between voltage-gated calcium channels (Ca(V)s) and calmodulin (CaM) modulate Ca(V) function. In this study, we report the structure of a Ca(2+)/CaM Ca(V)1...
  50. pmc Binding of calmodulin to the HIV-1 matrix protein triggers myristate exposure
    Ruba H Ghanam
    Department of Microbiology, University of Alabama, Birmingham, Alabama 35294, USA
    J Biol Chem 285:41911-20. 2010
    ..HIV-1 Gag was shown to interact and co-localize with calmodulin (CaM), a ubiquitous and highly conserved Ca(2+)-binding protein expressed in all eukaryotic cells, and is ..
  51. pmc Interaction of calmodulin with L-selectin at the membrane interface: implication on the regulation of L-selectin shedding
    Wei Deng
    Center for Membrane Biology, Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Mol Biol 411:220-33. 2011
    The calmodulin (CaM) hypothesis of ectodomain shedding stipulates that CaM, an intracellular Ca²⁺-dependent regulatory protein, associates with the cytoplasmic domain of L-selectin to regulate ectodomain shedding of L-selectin on the ..
  52. pmc NMR, biophysical, and biochemical studies reveal the minimal Calmodulin binding domain of the HIV-1 matrix protein
    Alexandra B Samal
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 286:33533-43. 2011
    Subcellular distribution of Calmodulin (CaM) in human immunodeficiency virus type-1 (HIV-1)-infected cells is distinct from that observed in uninfected cells...
  53. doi Association of calmodulin1 gene polymorphisms with susceptibility to adolescent idiopathic scoliosis
    Dong Zhao
    Department of Orthopaegdic Surgery, Peking Union Medical College Hospital, Beijing, China
    Orthop Surg 1:58-65. 2009
    ....
  54. pmc Role of the HIV-1 Matrix Protein in Gag Intracellular Trafficking and Targeting to the Plasma Membrane for Virus Assembly
    Ruba H Ghanam
    Department of Microbiology, University of Alabama at Birmingham Birmingham, AL, USA
    Front Microbiol 3:55. 2012
    ..Exposure of the myr group is also triggered by binding of calmodulin, enhanced by factors that promote protein self-association like the capsid domain of Gag, and is modulated by pH...
  55. ncbi Molecular mechanisms of calmodulin's functional versatility
    M Zhang
    Department of Biochemistry, Hong Kong University of Science and Technology, Kowloon, People s Republic of China
    Biochem Cell Biol 76:313-23. 1998
    b>Calmodulin (CaM) is a primary Ca2+-binding protein found in all eukaryotic cells...
  56. pmc Nef of HIV-1 interacts directly with calcium-bound calmodulin
    Nobuhiro Hayashi
    Division of Biomedical Polymer Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Protein Sci 11:529-37. 2002
    ..protein kinase C substrate, is essential for the interaction between the protein and Ca(2+)-bound calmodulin (Ca(2+)/CaM)...
  57. ncbi Sites on calmodulin that interact with the C-terminal tail of Cav1.2 channel
    Liangwen Xiong
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 280:7070-9. 2005
    ..2) have been expressed, refolded, and purified. A single Ca(2+)-calmodulin binds to each fragment, and this interaction with Ca(2+)-calmodulin is required for proper folding of the ..
  58. doi Solution X-ray scattering reveals a novel structure of calmodulin complexed with a binding domain peptide from the HIV-1 matrix protein p17
    Yoshinobu Izumi
    Graduate Program of Human Sensing and Functional Sensor Engineering, Yamagata University, 4 3 16, Jo nan, Yonezawa, Yamagata 992 8510, Japan
    Biochemistry 47:7158-66. 2008
    The solution structures of complexes between calcium-saturated calmodulin (Ca (2+)/CaM) and a CaM-binding domain of the HIV-1 matrix protein p17 have been determined by small-angle X-ray scattering with use of synchrotron radiation as an ..
  59. ncbi Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors
    Matthew J Mahon
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Wellman 501, Boston, MA 02114 2696, USA
    FEBS Lett 579:803-7. 2005
    ..The PTH1R, a class b GPCR, contains consensus calmodulin-binding motifs...
  60. ncbi Stimulation of calmodulin binding to skeletal muscle membrane proteins by 1,25-dihydroxy-vitamin D3
    V Massheimer
    , Universidad Nacional del Sur, , Argentina
    Z Naturforsch C 45:663-70. 1990
    Previous work has shown that 1,25-dihydroxy-vitamin D3 rapidly increases calmodulin levels of skeletal muscle membranes without altering the muscle cell calmodulin content...
  61. ncbi Inhibition of calmodulin-activated smooth-muscle myosin light-chain kinase by calmodulin-binding peptides and fluorescent (phosphodiesterase-activating) calmodulin derivatives
    K Torok
    School of Biological Sciences, Queen Mary and Westfield College, University of London, UK
    Biochemistry 37:6188-98. 1998
    Aspects of the biochemistry of calmodulin have been addressed that bear on its cell biological role as a mediator of Ca2+ regulation...
  62. ncbi Activation and inactivation of neuronal nitric oxide synthase: characterization of Ca(2+)-dependent [125I]Calmodulin binding
    Ben A Weissman
    Department of Pharmacology, Cornell University Medical College, New York, NY 10021, USA
    Eur J Pharmacol 435:9-18. 2002
    Constitutive isoforms of nitric oxide synthase (NOS) are activated by transient binding of Ca(2+)/Calmodulin. Here, we characterize the binding of Calmodulin to purified neuronal NOS (nNOS)...
  63. ncbi Blood carbon monoxide and hydrogen cyanide concentrations in the fatalities of fire and non-fire associated civil aviation accidents, 1991-1998
    A K Chaturvedi
    Toxicology and Accident Research Laboratory AAM 610, Aeromedical Research Division, Federal Aviation Administration, US Department of Transportation, Civil Aeromedical Institute, Oklahoma City, OK 73125 5066, USA
    Forensic Sci Int 121:183-8. 2001
    Blood samples submitted to the Civil Aeromedical Institute (CAMI) from aviation accident fatalities are analyzed for carbon monoxide (CO), as carboxyhemoglobin (COHb), and hydrogen cyanide, as cyanide (CN(-))...
  64. ncbi First-generation H1 antihistamines found in pilot fatalities of civil aviation accidents, 1990-2005
    Ahmet Sen
    Department of Aerospace Medicine, Gulhane Military Medical Academy, Eskisehir, Turkey
    Aviat Space Environ Med 78:514-22. 2007
    ..Such side effects could impair performance and, thus, could be the cause or a factor in accidents. Therefore, the prevalence of these antagonists was evaluated in aviation accident pilot fatalities...
  65. ncbi Prevalence of drugs and alcohol in fatal civil aviation accidents between 1994 and 1998
    D V Canfield
    Civil Aeromedical Institute, Federal Aviation Administration, Oklahoma City, OK 73125, USA
    Aviat Space Environ Med 72:120-4. 2001
    ..use of drugs and alcohol in aviation is closely monitored by the FAA Office of Aviation Medicine's (OAM's) Civil Aeromedical Institute (CAMI) through the toxicological analysis of specimens from pilots who have died in aviation accidents.
  66. ncbi Carboxyhemoglobin and blood cyanide concentrations in relation to aviation accidents
    Dennis V Canfield
    Civil Aerospace Medical Institute, Federal Aviation Administration, Oklahoma City, OK, USA
    Aviat Space Environ Med 76:978-80. 2005
    ..It is important in aviation accident investigations to determine if a fire occurred during flight or after the crash and to establish the source(s) of the toxic gases...
  67. ncbi Characteristics and toxicological processing of postmortem pilot specimens* from fatal civil aviation accidents
    Arvind K Chaturvedi
    Toxicology and Accident Research Laboratory, Aeromedical Research Division, Civil Aerospace Medical Institute, Federal Aviation Administration, U S Department of Transportation, Oklahoma City, OK 73125 5066, USA
    Aviat Space Environ Med 74:252-9. 2003
    ..biosamples from civil aviation accident pilot fatalities are submitted to the Civil Aerospace Medical Institute (CAMI) for toxicological evaluation...
  68. doi Regulation of IL2 and NUCB1 in mononuclear cells treated with acyl glucuronide of mycophenolic acid reveals effects independent of inosine monophosphate dehydrogenase inhibition
    Darinka T Petrova
    Department of Clinical Chemistry, Center 3 Biochemistry and Molecular Cell Biology, University Medicine Goettingen, Goettingen, Germany
    Ther Drug Monit 31:31-41. 2009
    ..05). The expression of interleukin 2 and nucleobindin 1 revealed an effect of AcMPAG on gene expression independent of inosine monophosphate dehydrogenase inhibition...
  69. ncbi Ethanol formation in unadulterated postmortem tissues
    Russell J Lewis
    Analytical Toxicology and Accident Research Laboratory, Civil Aerospace Medical Institute, Federal Aviation Administration, AAM 610, CAMI Building, Rm 205, 6500 S MacArthur Blvd, Oklahoma City, OK 73169 6901, USA
    Forensic Sci Int 146:17-24. 2004
    ..samples obtained from fatal accident victims are submitted to the FAA's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. During toxicological evaluations, ethanol analysis is performed on all cases...
  70. ncbi Toxicological findings from 1587 civil aviation accident pilot fatalities, 1999-2003
    Arvind K Chaturvedi
    Bioaeronautical Sciences Research Laboratory AAM 610, FAA Civil Aerospace Medical Institute, P O Box 25082, Oklahoma City, OK 73125 5066, USA
    Aviat Space Environ Med 76:1145-50. 2005
    ..In continuation, a toxicological assessment was made for an additional period of 5 yr...
  71. ncbi Quantitation of atenolol, metoprolol, and propranolol in postmortem human fluid and tissue specimens via LC/APCI-MS
    Robert D Johnson
    Civil Aerospace Medical Institute, Federal Aviation Administration, Analytical Toxicology and Accident Research Laboratory, AAM 610, CAMI Building, Rm 205, 6500 S MacArthur Blvd, Oklahoma City, OK 73169 6901, USA
    Forensic Sci Int 156:106-17. 2006
    ..The Civil Aerospace Medical Institute (CAMI) performs toxicological evaluation on victims of fatal aviation accidents...
  72. ncbi Novel late response genes of PTHrP in chondrocytes
    Jakomijn Hoogendam
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Horm Res 67:159-70. 2007
    ..The expression of late PTHrP response genes varied between ATDC5 chondrocytes, KS483 osteoblasts and metatarsals, suggesting that the expression of late response genes is dependent on the cellular context of the PTHrP responsive cells...
  73. ncbi Antiemetic and sedative levels found together in 26 civil aviation pilot fatalities, 2000-2006
    Sabra R Botch
    Civil Aerospace Medical Institute, Federal Aviation Administration, Analytical Toxicology and Accident Research Laboratory, AAM 610, CAMI Building, RM 351, 6500 S MacArthur Blvd, Oklahoma City, OK 73169 6901, USA
    Aviat Space Environ Med 79:607-10. 2008
    ..Our laboratory was interested in evaluating the circumstances surrounding accidents in which the pilot was found positive for drugs from each of these two classes...
  74. doi Developmental changes of gene expression after spinal cord injury in neonatal opossums
    Miranda Mladinic
    SISSA, Department of Neurobiology, via Bonomea 265, 34136 Trieste, Italy
    Brain Res 1363:20-39. 2010
    ..Certain genes such as calmodulin 1 and NOGO, changed expression similarly in animals that could and could not regenerate without any additional ..
  75. pmc Motivational intervention to reduce rapid subsequent births to adolescent mothers: a community-based randomized trial
    Beth Barnet
    Department of Family and Community Medicine, University of Maryland School of Medicine, Baltimore, Maryland
    Ann Fam Med 7:436-45. 2009
    ..Most efforts to prevent rapid subsequent birth to teenagers have been unsuccessful but have seldom addressed motivational processes...
  76. pmc Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart
    Nathalie Gaborit
    INSERM U533, Nantes, France
    J Physiol 582:675-93. 2007
    ..Concordance with previous functional studies suggests that regional regulation of cardiac ion-current expression may be primarily transcriptional...
  77. pmc Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse
    Elin Lehrmann
    Cellular Neurobiology Research Branch and Chemistry and Drug Metabolism Section, National Institute on Drug Abuse NIDA Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
    PLoS ONE 1:e114. 2006
    ..for a majority of drug abuse cases (N = 34), representing a number of consistently changed functional classes: Calmodulin-related transcripts (CALM1, CALM2, CAMK2B) were decreased, while transcripts related to cholesterol biosynthesis ..
  78. ncbi Calcium-calmodulin is required for abscisic acid-induced antioxidant defense and functions both upstream and downstream of H2O2 production in leaves of maize (Zea mays) plants
    Xiuli Hu
    College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China
    New Phytol 173:27-38. 2007
    Using pharmacological and biochemical approaches, the role of calmodulin (CaM) and the relationship between CaM and hydrogen peroxide (H(2)O(2)) in abscisic acid (ABA)-induced antioxidant defense in leaves of maize (Zea mays) plants ..
  79. doi Randomized study of different anti-stigma media
    Joseph Finkelstein
    Chronic Disease Informatics Group, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Patient Educ Couns 71:204-14. 2008
    ..We designed our study to assess if computer-assisted anti-stigma interventions can be effective in reducing the level of psychiatric stigma in a sample of special education university students...
  80. ncbi Genetic determinants of emotionality and stress response in AcB/BcA recombinant congenic mice and in silico evidence of convergence with cardiovascular candidate genes
    Stéphane Thifault
    Centre de Recherche, Centre hospitalier de l Université de Montréal Technopôle Angus, Montreal, Quebec, Canada
    Hum Mol Genet 17:331-44. 2008
    ..6), in the dopa decarboxylase region on Chr 11 for the plus-maze (LOD = 4.7), and within a novel region of calmodulin 1 on Chr 12 for Ca++ excretion after a 24-h salt load (LOD = 4.6)...
  81. ncbi Effects of cyclodiene compounds on calcium pump activity in rat brain and heart
    B D Mehrotra
    Department of Chemistry, Tougaloo College, MS 39174
    Toxicology 54:17-29. 1989
    The in vitro and in vivo effects of aldrin, dieldrin, and endrin on calmodulin regulated Ca2+-pump activity in rat brain synaptosomes and heart sarcoplasmic reticulum were investigated...
  82. ncbi Effect of partner relationship on motivation to use condoms among adolescent mothers
    Belinda D Johnston-Briggs
    Department of Family and Community Medicine, University of Maryland School of Medicine, 29 S Paca St, Baltimore, MD 21201, USA
    J Natl Med Assoc 100:929-35. 2008
    ..Adolescent mothers have high rates of repeat pregnancy and sexually transmitted infections (STIs). We sought to identify factors associated with their consistent condom use...
  83. ncbi Polymorphism in signal transduction is a major route through which osteoarthritis susceptibility is acting
    John Loughlin
    University Lecturer in Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, UK
    Curr Opin Rheumatol 17:629-33. 2005
    ..In the last year there has been considerable success in the identification of genes harbouring susceptibility for primary osteoarthritis. This report brings the reader up-to-date by focusing on three of the more compelling finds...
  84. ncbi Chronic administration of genistein improves endothelial dysfunction in spontaneously hypertensive rats: involvement of eNOS, caveolin and calmodulin expression and NADPH oxidase activity
    Rocio Vera
    Department of Pharmacology, School of Pharmacy, University of Granada, 18071 Granada, Spain
    Clin Sci (Lond) 112:183-91. 2007
    ..5 mg.kg(-1) of body weight.day(-1)). Vascular expression of eNOS, caveolin-1 and calmodulin-1 were analysed by Western blotting, eNOS activity by conversion of [(3)H]arginine into L-[(3)H]citrulline and O(..
  85. ncbi Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee
    Ana M Valdes
    St Thomas Hospital, and King s College London, London, UK
    Arthritis Rheum 56:137-46. 2007
    ..To assess whether the association of genetic polymorphisms with osteoarthritis (OA) in other populations could be replicated in a large, multicenter, mixed-sex, case-control study of clinical knee OA...
  86. ncbi Prognostic role of post-infarction C-reactive protein in patients undergoing implantation of cardioverter-defibrillators: design of the C-reactive protein Assessment after Myocardial Infarction to GUide Implantation of DEfibrillator (CAMI GUIDE) study
    Fulvio Bellocci
    Institute of Cardiology, Catholic University, A Gemelli Hospital, Rome, Italy
    J Cardiovasc Med (Hagerstown) 8:293-9. 2007
    ..Whether C-reactive protein (CRP), a serum inflammatory marker with established prognostic accuracy after MI, can also be a predictor of SCD is unclear...
  87. ncbi Intracellular calcium stores in beta-escin skinned rat and guinea-pig bladders
    N Tugba Durlu-Kandilci
    Hacettepe University, Faculty of Pharmacy, Department of Pharmacology, 06100, Sihhiye, Ankara, Turkey
    Eur J Pharmacol 566:172-80. 2007
    ..b>Calmodulin (1 microM) increased the calcium contractions significantly...
  88. doi Development and initial psychometric properties of the Computer Assisted Maltreatment Inventory (CAMI): a comprehensive self-report measure of child maltreatment history
    David DiLillo
    University of Nebraska Lincoln, Department of Psychology, Lincoln, NE 68588, USA
    Child Abuse Negl 34:305-17. 2010
    ..reports on the development and initial psychometric properties of the Computer Assisted Maltreatment Inventory (CAMI), a web-based self-report measure of child maltreatment history, including sexual and physical abuse, exposure to ..
  89. pmc Depletion of synovial macrophages in rheumatoid arthritis by an anti-FcgammaRI-calicheamicin immunoconjugate
    J A G van Roon
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, F02 127, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 64:865-70. 2005
    ..Monocytes/macrophages have an important and versatile role in joint inflammation and destruction in rheumatoid arthritis (RA)...
  90. ncbi [Evaluation of diagnosis and prediction of degree of coronary stenosis by CAVI]
    Wei Zhang
    General Hospital of Beijing Military Region Beijing, China
    Zhonghua Yi Xue Za Zhi 89:2280-2. 2009
    ....
  91. pmc Accuracy of a remote quantitative image analysis in the whole slide images
    Janina Słodkowska
    Military Institute of Medicine, Department of Pathology, Warsaw, Poland
    Diagn Pathol 6:S20. 2011
    ..Recently we have introduced the Computerized Analysis of Medical Images [CAMI] software for an automated Ki-67 LI counting in the digital images...
  92. doi Coping with the caregiving role: differences between primary and secondary caregivers of dependent elderly people
    Ana Barbosa
    Department of Health Sciences, University of Aveiro, Campus Universitario de Santiago, Aveiro, Portugal
    Aging Ment Health 15:490-9. 2011
    ..This cross-sectional study aims to analyse and compare the use and effectiveness of coping strategies of primary and secondary informal caregivers of dependent elderly people, living at home...
  93. ncbi Ca(2+)-dependent inhibition of inwardly rectifying K(+) channel in opossum kidney cells
    Y Mori
    Department of Physiology II, Osaka Medical College, Takatsuki, 569 8686 Japan
    Jpn J Physiol 51:371-80. 2001
    ..By contrast, the application of Ca(2+)/calmodulin kinase II (CaMK II, 300 pM) dramatically increased this channel activity in inside-out patches...
  94. doi Cross-talk between calcium-calmodulin and nitric oxide in abscisic acid signaling in leaves of maize plants
    Jianrong Sang
    College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China
    Cell Res 18:577-88. 2008
    ..and biochemical approaches, the signaling pathways between hydrogen peroxide (H(2)O(2)), calcium (Ca(2+))-calmodulin (CaM), and nitric oxide (NO) in abscisic acid (ABA)-induced antioxidant defense were investigated in leaves of ..
  95. doi Identification of sequence polymorphisms in CALM2 and analysis of association with hip osteoarthritis in a Japanese population
    Hideyuki Mototani
    Pharmacology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 17 85 Jusohonmachi 2 Chome, Yodogawa ku, Osaka 532 8686, Japan
    J Bone Miner Metab 28:547-53. 2010
    ..an association between a functional single nucleotide polymorphism (SNP) in the core promoter region of the calmodulin (CaM) 1 gene (CALM1) and hip OA. CaM plays an important role in maintaining cartilage phenotype...
  96. doi Cost-effectiveness of a motivational intervention to reduce rapid repeated childbearing in high-risk adolescent mothers: a rebirth of economic and policy considerations
    Beth Barnet
    Department of Family and Community Medicine, University of Maryland School of Medicine, 29 S Paca St Lower Level, Baltimore, MD 21201, USA
    Arch Pediatr Adolesc Med 164:370-6. 2010
    ..To determine the cost-effectiveness of an intervention that successfully reduced rapid repeated births within 2 years of an index birth to adolescent mothers...
  97. ncbi Percutaneous interventions in patients with cocaine-associated myocardial infarction: a case series and review
    Arvind K Sharma
    Section of Cardiology, Washington Hospital Center, Washington, DC 20010, USA
    Catheter Cardiovasc Interv 56:346-52. 2002
    Cocaine-associated myocardial infarction (CAMI) is a well-reported entity. Most previous reports on CAMI have been limited to conservative care utilizing benzodiazepines, aspirin, nitroglycerin, calcium channel blockers, and thrombolytics...
  98. ncbi CaMi, a root-knot nematode resistance gene from hot pepper (Capsium annuum L.) confers nematode resistance in tomato
    Rugang Chen
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China
    Plant Cell Rep 26:895-905. 2007
    ..In this study, a candidate root-knot nematode resistance gene (designated as CaMi) was isolated from the resistant pepper line PR 205 by degenerate PCR amplification combined with the RACE ..
  99. doi Components of the difficulties, satisfactions and management strategies of carers of older people: a principal component analysis of CADI-CASI-CAMI
    Kevin McKee
    University of Sheffield, Sheffield Institute for Studies on Ageing, Sheffield, UK
    Aging Ment Health 13:255-64. 2009
    To perform a psychometric evaluation of the Carers Assessment of Difficulties Index, Carers Assessment of Satisfactions Index and the Carers Assessment of Managing Index (CADI-CASI-CAMI).
  100. doi Cambridge-Miami score for intestinal transplantation preoperative risk assessment: initial development and validation
    S J Middleton
    Department of Gastroenterology, Addenbrooke s, Cambridge University Teaching Hospital, UK
    Transplant Proc 42:19-21. 2010
    ..We have developed a preliminary preoperative scoring system, called the Cambridge-Miami (CaMi) score, for transplantation of the small intestine either alone or as a composite graft.
  101. pmc Ligand sensitivity of the 2 subunit from the bovine cone cGMP-gated channel is modulated by protein kinase C but not by calmodulin
    F Muller
    Institut für Biologische Informationsverarbeitung, Forschungszentrum Julich, 52425 Julich, Germany
    J Physiol 532:399-409. 2001
    ..Modulation of cGMP sensitivity by protein kinase C (PKC)-mediated phosphorylation and by binding of calmodulin (CaM) was investigated in inside-out patches. 2...

Research Grants21

  1. LYN A STEIN; Fiscal Year: 2015
    ..we have adapted Computer Assisted Motivational Interviewing (CAMI25), and plan to implement and evaluate CAMI for increasing the initiation and continuation of highly effective contraceptive methods among girls at risk for an ..
  2. MI: Empowering Women to Make Contraceptive Choices While Incarcerated
    JENNIFER GRACE CLARKE; Fiscal Year: 2012
    ..Building upon program experience and prior evaluations we have adapted CAMI, and plan to implement and evaluate MICA for increasing the initiation and continuation of highly effective ..
  3. Prevention Technologies for Sexual and Reproductive Health Conference
    Susan Ivey; Fiscal Year: 2009
    ..UCSF Women's Global Health Imperative, UCSF Center for AIDS Research, the California Microbicide Initiative (CaMI), UC Davis Medical Center, Sacramento Black Chamber of Commerce, California African American HIV/AIDS Coalition, ..
  4. DEVELOPMENT OF NEW RENAL FUNCTION IMAGING AGENTS
    John Babich; Fiscal Year: 1999
    ..A new prototype hydrophilic penta-anionic complex [Technetium (Carboxy- methyl-isocyanide)6]-5 (Tc-CAMI) has been synthesized and evaluated in animals...
  5. Computer-Aided Counseling to Prevent Teen Pregnancy/STDs
    Melanie Gold; Fiscal Year: 2006
    ..hospital-based clinic and randomizing them to either an innovative Computer-Assisted Motivational Intervention (CAMI) or a Didactic Educational Control (DEC)...
  6. AUREL B CAMI; Fiscal Year: 2014
    ..Aurel Cami's development into an independent investigator in the field of Biomedical Informatics...
  7. Mapping the Drugome: predictive network approaches to drug safety surveillance
    AUREL B CAMI; Fiscal Year: 2012
    ..Aurel Cami's development into an independent investigator in the field of Biomedical Informatics...
  8. TECHNIQUES FOR CALCULATING TUMOR DOSIMETRY FROM IMAGING
    KENNETH KORAL; Fiscal Year: 2003
    ..versus conjugate views for the task of estimating tumor activity, augment the Computer Assisted Matrix Inversion (CAMI) method of conjugate views by a fusion of 3-D CT to 2-D projection, and evaluate the augmented CAMI method for ..
  9. Culturally Adapted Motivational Interviewing Hispanics
    Christina Lee; Fiscal Year: 2009
    ..Primary research aims of this application are to develop and evaluate a culturally adapted motivational interview (CAMI), and to compare the efficacy of this intervention with standard motivational interview (SMI)...
  10. Dissecting the Molecular Pathology of LAM Disease
    Daniel Noonan; Fiscal Year: 2005
    ..events mediated by estrogen activation of its intracellular receptor (ER) and the intracellular signaling switch calmodulin (CaM)...
  11. Cell Signaling by G Protein betagamma Subunits
    James Garrison; Fiscal Year: 2008
    ..Parameters examined will include: receptor - alpha:betagamma interaction, adenylyl cyclase (cAMP), PLC-beta (Ca2+), Ptdlns 3-kinase (PIP3), P-Rex1 (Rac activation) and cell migration. ..
  12. INSULIN ACTION IN MUSCLE AND FAT CELLS
    JAMES CARLTON GARRISON; Fiscal Year: 2010
    ..Lentivirus will be used to overexpress rictor or to express shRNA to knockdown rictor in 3T3-L1 adipocytes. To investigate mTORC2 function in vivo, we propose to knockout rictor in adipocytes and skeletal muscle of mice. ..
  13. G-protein Regulation of the Phosphatidyl Inositol (3,4,5) Trisphosphate Signal
    James Garrison; Fiscal Year: 2009
    ..abstract_text> ..
  14. Neuroprotection by Novel Regulators of mGluR Signaling
    Julie Saugstad; Fiscal Year: 2009
    ..abstract_text> ..
  15. Calcium-Dependent Protein Regulation
    JOHN PUTKEY; Fiscal Year: 2008
    PEP-19, neurogranin and neuromodulin are Small Neuronal IQ motif (SNIQs) calmodulin (CaM) binding proteins found in high abundance throughout the nervous system...
  16. Family Functioning of Adults Maltreated as Children
    David DiLillo; Fiscal Year: 2007
    ..abstract_text> ..
  17. Role of Acid-Sensing Ion Channels in Glaucoma
    Julie Saugstad; Fiscal Year: 2006
    ..abstract_text> ..
  18. Extracellular Modulation of Metabotropic GluRs
    Julie Saugstad; Fiscal Year: 2005
    ..abstract_text> ..
  19. EVALUATION OF HOME ASTHMA TELEMONITORING (HAT) IN ADULTS
    Joseph Finkelstein; Fiscal Year: 2003
    ..Lastly, we will evaluate the HAT impact on behavioral and cognitive components of asthma self-care, including phase of asthma self-regulation, asthma self-efficacy and knowledge. ..
  20. REGULATION OF METABOTROPIC GLUTAMATE RECEPTOR RESPONSES
    Julie Saugstad; Fiscal Year: 2002
    ..abstract_text> ..
  21. Role of MicroRNAs in Ischemic Tolerance
    Julie Saugstad; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..