calcitonin

Summary

Gene Symbol: calcitonin
Description: calcitonin related polypeptide alpha
Alias: CALC1, CGRP, CGRP-I, CGRP1, PCT, calcitonin, calcitonin gene-related peptide 1, alpha-type CGRP, calcitonin 1, calcitonin gene-related peptide I, calcitonin/calcitonin-related polypeptide, alpha, katacalcin
Species: human

Top Publications

  1. ncbi Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics
    A L Breeze
    Department of Biochemistry, University of Oxford, U K
    Biochemistry 30:575-82. 1991
  2. ncbi RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    L M McLatchie
    Receptor Systems and Cell Biology Units, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, UK
    Nature 393:333-9. 1998
  3. ncbi Increased blood pressure in alpha-calcitonin gene-related peptide/calcitonin gene knockout mice
    P R Gangula
    Departments of Obstetrics and Gynecology, Internal Medicine, and Anatomy and Neurosciences, The University of Texas Medical Branch, Galveston, TX 77555 1062, USA
    Hypertension 35:470-5. 2000
  4. pmc The role of the 8-18 helix of CGRP8-37 in mediating high affinity binding to CGRP receptors; coulombic and steric interactions
    Stephen G Howitt
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET
    Br J Pharmacol 138:325-32. 2003
  5. ncbi Molecular approximation between a residue in the amino-terminal region of calcitonin and the third extracellular loop of the class B G protein-coupled calcitonin receptor
    Maoqing Dong
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    J Biol Chem 279:31177-82. 2004
  6. ncbi CGRP inhibits osteoprotegerin production in human osteoblast-like cells via cAMP/PKA-dependent pathway
    I Villa
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Am J Physiol Cell Physiol 291:C529-37. 2006
  7. ncbi Procalcitonin for the clinical laboratory: a review
    Hans Gerhard Schneider
    Clinical Biochemistry Unit, Alfred Pathology Service, The Alfred Hospital, Monash University, Melbourne, Australia
    Pathology 39:383-90. 2007
  8. doi Assessment of the prognostic value of certain acute-phase proteins and procalcitonin in the prognosis of acute pancreatitis
    Anna Gurda-Duda
    Department of General and GI Surgery, Faculty of Medicine, Medical College, Jagiellonian University, Krakow, Poland
    Pancreas 37:449-53. 2008
  9. doi Procalcitonin values after dialysis is closely related to type of dialysis membrane
    Martina Montagnana
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Ospedale Policlinico G B Rossi, Piazzale Scuro, 10, Verona 37134, Italy
    Scand J Clin Lab Invest 69:703-7. 2009
  10. doi The value of procalcitonin at predicting the severity of acute pancreatitis and development of infected pancreatic necrosis: systematic review
    Reza Mofidi
    Department of Clinical and Surgical Sciences Surgery, University of Edinburgh, Edinburgh, United Kingdom
    Surgery 146:72-81. 2009

Research Grants

  1. NICOLE LEANNE WARD; Fiscal Year: 2014
  2. Rodger A Liddle; Fiscal Year: 2016
  3. Spinal Cord-Mediated Acute Neurogenic Inflammation
    Qing Lin; Fiscal Year: 2010
  4. The role of BNST CGRP in stress-enhanced anxiety behavior and HPA-axis function
    Kelly S Sink; Fiscal Year: 2013
  5. Mechanisms of airway neurogenic inflammation by asthma-inducing allergens
    Armen N Akopian; Fiscal Year: 2013
  6. Andrew F Russo; Fiscal Year: 2015
  7. NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATION
    Eileen Grady; Fiscal Year: 2006
  8. Ontogeny of CRLR and RAMPs in Myometrium
    Chandrasekhar Yallampalli; Fiscal Year: 2002
  9. Liya Qiao; Fiscal Year: 2016
  10. Treat Neuropathic Pain with Dissolvable Microneedles Containing Anti-CGRP Peptide
    Xinmin Simon Xie; Fiscal Year: 2013

Patents

  1. Biologically active peptides

Detail Information

Publications576 found, 100 shown here

  1. ncbi Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics
    A L Breeze
    Department of Biochemistry, University of Oxford, U K
    Biochemistry 30:575-82. 1991
    The structure of human calcitonin gene-related peptide 1 (hCGRP-1) has been determined by 1H NMR in a mixed-solvent system of 50% trifluoroethanol/50% H2O at pH 3.7 and 27 degrees C...
  2. ncbi RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    L M McLatchie
    Receptor Systems and Cell Biology Units, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, UK
    Nature 393:333-9. 1998
    b>Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharmacological profiles...
  3. ncbi Increased blood pressure in alpha-calcitonin gene-related peptide/calcitonin gene knockout mice
    P R Gangula
    Departments of Obstetrics and Gynecology, Internal Medicine, and Anatomy and Neurosciences, The University of Texas Medical Branch, Galveston, TX 77555 1062, USA
    Hypertension 35:470-5. 2000
    Nerves that contain calcitonin gene-related peptide (CGRP) are components of the sensory nervous system...
  4. pmc The role of the 8-18 helix of CGRP8-37 in mediating high affinity binding to CGRP receptors; coulombic and steric interactions
    Stephen G Howitt
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET
    Br J Pharmacol 138:325-32. 2003
    1. The role of individual residues in the 8-18 helix of CGRP(8-37) in promoting high-affinity binding to CGRP(1) receptors expressed on rat L6 and human SK-N-MC cells has been examined...
  5. ncbi Molecular approximation between a residue in the amino-terminal region of calcitonin and the third extracellular loop of the class B G protein-coupled calcitonin receptor
    Maoqing Dong
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    J Biol Chem 279:31177-82. 2004
    The calcitonin receptor is a member of the class B family of G protein-coupled receptors, which contains numerous potentially important drug targets...
  6. ncbi CGRP inhibits osteoprotegerin production in human osteoblast-like cells via cAMP/PKA-dependent pathway
    I Villa
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Am J Physiol Cell Physiol 291:C529-37. 2006
    ..Primary cultures of human osteoblast-like cells (hOB) express calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1, and, because CGRP stimulates cAMP (one ..
  7. ncbi Procalcitonin for the clinical laboratory: a review
    Hans Gerhard Schneider
    Clinical Biochemistry Unit, Alfred Pathology Service, The Alfred Hospital, Monash University, Melbourne, Australia
    Pathology 39:383-90. 2007
    ..It has obtained FDA approval and is now widely marketed in the United States and Europe. This review summarises the current assays available, the evidence for its use and possible future applications of the assay...
  8. doi Assessment of the prognostic value of certain acute-phase proteins and procalcitonin in the prognosis of acute pancreatitis
    Anna Gurda-Duda
    Department of General and GI Surgery, Faculty of Medicine, Medical College, Jagiellonian University, Krakow, Poland
    Pancreas 37:449-53. 2008
    ..The aim of this study was to evaluate the role of serum amyloid A, C-reactive protein, procalcitonin, and routinely measured parameters in the early prediction of the course of AP...
  9. doi Procalcitonin values after dialysis is closely related to type of dialysis membrane
    Martina Montagnana
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Ospedale Policlinico G B Rossi, Piazzale Scuro, 10, Verona 37134, Italy
    Scand J Clin Lab Invest 69:703-7. 2009
    ..In this setting, procalcitonin (PCT) could be useful for detection of systemic bacterial infections.
  10. doi The value of procalcitonin at predicting the severity of acute pancreatitis and development of infected pancreatic necrosis: systematic review
    Reza Mofidi
    Department of Clinical and Surgical Sciences Surgery, University of Edinburgh, Edinburgh, United Kingdom
    Surgery 146:72-81. 2009
    Many studies have evaluated serum levels of procalcitonin (PCT) as a predictor in the development of severe acute pancreatitis (SAP) and infected pancreatic necrosis (IPN)...
  11. doi [Comparison of diagnostic utility between procalcitonin and C-reactive protein for the patients with blood culture-positive sepsis]
    Mina Hur
    Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea
    Korean J Lab Med 29:529-35. 2009
    Procalcitonin (PCT) is a relatively new marker for bacterial infections, and its diagnostic utility has been variable across the studies...
  12. doi Prognostic value of inflammatory markers (notably cytokines and procalcitonin), nutritional assessment, and organ function in patients with sepsis
    Marta Suárez-Santamaría
    Biochemistry Laboratory, University Hospital of the Canary Islands, Tenerife, Spain
    Eur Cytokine Netw 21:19-26. 2010
    ..Our objective was to determine the prognostic value of procalcitonin determined at the onset of sepsis, and to compare it with other markers of inflammatory response, malnutrition and organ dysfunction data...
  13. doi Prognostic value of procalcitonin in community-acquired pneumonia
    P Schuetz
    Harvard School of Public Health, Boston, MA 02115, USA
    Eur Respir J 37:384-92. 2011
    The prognostic value of procalcitonin (PCT) levels to predict mortality and other adverse events in community-acquired pneumonia (CAP) remains undefined...
  14. pmc Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study
    Sari Karlsson
    Department of Intensive Care Medicine, Tampere University Hospital, Teiskontie 35, 33521 Tampere, Finland
    Crit Care 14:R205. 2010
    This prospective study investigated the predictive value of procalcitonin (PCT) for survival in 242 adult patients with severe sepsis and septic shock treated in intensive care.
  15. pmc Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function
    James Barwell
    School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK
    Biochim Biophys Acta 1813:1906-16. 2011
    ..an alanine/leucine scan of ECLs 1 and 3 and loop-associated transmembrane (TM) domains of the secretin-like GPCR calcitonin receptor-like receptor which associates with receptor activity modifying protein 1 to form the CGRP receptor...
  16. ncbi Effects of CGRP on human osteoclast-like cell formation: a possible connection with the bone loss in neurological disorders?
    A Akopian
    Laboratory of Experimental Hematology, at CHU Brugmann, Universite Libre de Bruxelles, 4 Place Van Gehuchten, 1020 Brussels, Belgium
    Peptides 21:559-64. 2000
    ..Among the neuropeptides recently described in bone, calcitonin gene-related peptide (CGRP) has been shown in animal studies to inhibit bone resorption in vivo and OCL-like ..
  17. ncbi Identification of four novel polymorphisms in the calcitonin/alpha-CGRP (CALCA) gene and an investigation of their possible associations with Parkinson disease, schizophrenia, and manic depression
    S Buervenich
    Department of Neuroscience, Karolinska Institute, Berzelius väg 3, 17177 Stockholm, Sweden
    Hum Mutat 17:435-6. 2001
    We identified novel polymorphisms in the calcitonin/CGRPalpha (CALCA) gene by direct sequencing of genomic DNA and subsequent genotyping by RFLP (restriction fragment length polymorphism) detection and investigated association with ..
  18. ncbi Calcitonin gene polymorphism CALCA-624 (T/C) and ovarian cancer
    Marc T Goodman
    Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Environ Mol Mutagen 46:53-8. 2005
    ..2002. Am J Epidemiol 156:148-57). The CALCA gene codes for calcitonin, an important regulator of bone calcium metabolism...
  19. ncbi Association between the calcitonin-related peptide alpha (CALCA) gene and essential hypertension in Japanese subjects
    Akihiko Morita
    Division of Neurology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Hypertens 20:527-32. 2007
    b>Calcitonin-related peptide alpha (CALCA) is a neuropeptide that is a very potent vasodilator. It has been reported that CALCA knockout mice have a significantly elevated systolic blood pressure (BP)...
  20. pmc Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins
    Benjamin E Padilla
    Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 179:981-97. 2007
    ..b>Calcitonin gene-related peptide (CGRP) co-internalizes with calcitonin receptor-like receptor (CLR), receptor activity-..
  21. pmc Calcitonin gene-related peptide biases Langerhans cells toward Th2-type immunity
    Wanhong Ding
    Department of Dermatology, Weill Cornell Medical College, New York, NY 10021, USA
    J Immunol 181:6020-6. 2008
    ..LC are associated with nerves containing the neuropeptide calcitonin gene-related peptide (CGRP), and CGRP inhibits LC Ag-presentation in several models including presentation to a ..
  22. pmc BCL2-938C>A and CALCA-1786T>C polymorphisms in aseptic loosened total hip arthroplasty
    Christian Wedemeyer
    Department of Orthopaedics, University of Duisburg Essen, Germany
    Eur J Med Res 14:250-5. 2009
    ..The CALCA -1786T>C polymorphism belongs to the CALCA gene encoding alpha-Calcitonin Gene Related Peptide (CGRP) and Calcitonin...
  23. doi Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study
    D Stolz
    Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital, Petersgraben 4, CH 4031 Basel, Switzerland
    Eur Respir J 34:1364-75. 2009
    ..Serum procalcitonin reduces antibiotic therapy exposure in patients with ventilator associated pneumonia...
  24. doi Temporal and spatial CGRP innervation in recombinant human bone morphogenetic protein induced spinal fusion in rabbits
    Xiao Yun Wang
    Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong
    Spine (Phila Pa 1976) 34:2363-8. 2009
    ..Animal experiment using a rabbit posterolateral intertransverse process fusion model...
  25. doi Effect of calcitonin gene-related peptide on nitric oxide production in osteoblasts: an experimental study
    Li Yan
    Department of Oral and Maxillofacial Surgery, Xingqiao Hospital, Third Military Medical University, Chongqing, Peoples Republic of China
    Cell Biol Int 35:757-65. 2011
    The aim of this study was to investigate the in vitro effects and regulatory mechanism of CGRP (calcitonin gene-related peptide) on NO (nitric oxide) production in osteoblasts...
  26. ncbi Comparison of serum procalcitonin with Ranson, APACHE-II, Glasgow and Balthazar CT severity index scores in predicting severity of acute pancreatitis
    Su Mi Woo
    Department of Internal Medicine, Dong A University College of Medicine, Busan, Korea
    Korean J Gastroenterol 58:31-7. 2011
    The aim of this study is to assess serum procalcitonin (PCT) for early prediction of severe acute pancreatitis compared with multiple scoring systems and biomarkers.
  27. ncbi High concentrations of procalcitonin but not mature calcitonin in normal human milk
    J Struck
    Research Laboratories, B R A H M S AG, Biotechnology Center Hennigsdorf, Hennigsdorf, Germany
    Horm Metab Res 34:460-5. 2002
    Procalcitonin (PCT) is one of the precursors in the synthesis of calcitonin in thyroidal C-cells and other neuroendocrine cells...
  28. pmc Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia
    B Safieh Garabedian
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 115:1265-75. 1995
    ..IL-1 beta) and nerve growth factor (NGF) levels in the inflamed tissue and of the peptides, substance P and calcitonin gene-related peptide (CGRP) in the L4 dorsal root ganglion 48 h post CFA injection. 3...
  29. pmc Interaction of human adrenomedullin 13-52 with calcitonin gene-related peptide receptors in the microvasculature of the rat and hamster
    J M Hall
    Biomedical Sciences Division, King s College London
    Br J Pharmacol 114:592-7. 1995
    ..circulating hypotensive peptide, shares limited sequence homology with the sensory nerve-derived vasodilator, calcitonin gene-related peptide (CGRP)...
  30. pmc Inhibition by SR 140333 of NK1 tachykinin receptor-evoked, nitric oxide-dependent vasodilatation in the hamster cheek pouch microvasculature in vivo
    J M Hall
    Biomedical Sciences Division, King s College London
    Br J Pharmacol 113:522-6. 1994
    ..SR140333 (10 nM) did not inhibit submaximal dilator responses evoked by human alpha calcitonin gene-related peptide (alpha CGRPh; 1.0 nM; P > 0.05; n = 5)...
  31. ncbi Characterization of the structural and functional properties of cloned calcitonin receptor cDNAs
    S R Goldring
    Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Boston
    Horm Metab Res 25:477-80. 1993
    ..Both CTRs demonstrate low affinity binding and AC activation in response to calcitonin gene related peptide, amylin or secretin, providing a possible explanation for the cross-reactivity among these ..
  32. pmc Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema
    H Inoue
    Research Laboratory, Minophagen Pharmaceutical Co, Kanagawa, Japan
    Br J Pharmacol 110:1614-20. 1993
    ..v.), an aminopeptidase, failed to enhance oedema formation. 5. Neuropeptides (1-100 pmol per site) such as rat calcitonin gene-related peptide (CGRP), SP, neurokinin A (NKA), and vasoactive intestinal peptide (VIP), which are released ..
  33. ncbi Deficiency of tumor necrosis factor alpha in a subclass of menstrual migraineurs
    L Mueller
    Department of Family Medicine, University Headache Center, University of Medicine and Dentistry of New Jersey, Moorestown, NJ 08057, USA
    Headache 41:129-37. 2001
    ..Vasoactive substances involved in this process may include substance P, calcitonin gene-related peptide, neurokinin A, serotonin, and nitric oxide...
  34. pmc The influence of the trigeminal ganglion on carotid blood flow in anaesthetized guinea-pigs
    D T Beattie
    Pharmacology II, Glaxo Research and Development Ltd, Ware, Herts
    Br J Pharmacol 112:262-6. 1994
    ..3 mg kg-1) and CP-99,994 (0.4 mg kg-1), calcitonin gene-related peptide (CGRP) receptor antagonist, CGRP8-37 (0...
  35. pmc Characterization of the receptor and the mechanisms underlying the inflammatory response induced by des-Arg9-BK in mouse pleurisy
    R M Vianna
    Department of Pharmacology, Centre of Biological Sciences, Universidade Federal de Santa Catarina, , Brazil
    Br J Pharmacol 123:281-91. 1998
    ..An i.t. injection of the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP8-37 (1 nmol per site), administered 5 min before pleurisy ..
  36. ncbi Substance P theory: a unique focus on the painful and painless phenomena of cluster headache
    F Sicuteri
    Institute of Internal Medicine and Therapy, IV, University of Florence, Italy
    Headache 30:69-79. 1990
    ..of the iris in CH); substance P (SP) and allied transmitters such as Vasoactive Intestinal Peptide (VIP) and Calcitonin Gene-Related Peptide (CGRP) are the main agonists of this dual afferent-efferent function; b) impaired pain ..
  37. ncbi [Role of neuropeptides in dermatology]
    I Sanchez-Carpintero
    Departamento de Dermatologia, Clinica Universitaria, Facultad de Medicina, Universidad de Navarra, Pamplona, Espana
    Rev Neurol 25:S222-31. 1997
    ..In this article we attempt to study the role played by some of these substances such as substance P (SP), calcitonin gene related peptide (CGRP), neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), somatostatin (S), and ..
  38. ncbi Inhibition of natural killer activity by calcitonin gene-related peptide
    Y Umeda
    Department of Chemotherapy and Biochemistry, Nippon Roche Research Center, Kamakura, Japan
    Immunopharmacol Immunotoxicol 11:309-20. 1989
    The effect of calcitonin gene-related peptide (CGRP) on natural killer (NK) cell activity in spleen cells from Balb/c mice and nude mice was studied...
  39. pmc Potentiation by tonic A2a-adenosine receptor activation of CGRP-facilitated [3H]-ACh release from rat motor nerve endings
    P Correia-de-Sá
    Laboratory of Pharmacology, ICBAS, University of Oporto, Portugal
    Br J Pharmacol 111:582-8. 1994
    1. The effect of calcitonin gene-related peptide (CGRP) on [3H]-acetylcholine ([3H]-ACh) release from motor nerve endings and its interaction with presynaptic facilitatory A2a-adenosine and nicotinic acetylcholine receptors was studied on ..
  40. pmc Calcitonin gene-related peptide receptors in human gastrointestinal epithelia
    H M Cox
    Department of Pharmacology, Royal College of Surgeons of England, London
    Br J Pharmacol 113:1243-8. 1994
    1. The secretory responses to calcitonin gene-related peptide (CGRP) receptor agonists have been characterized in two human adenocarcinoma cell lines, namely HCA-7 and Colony-29 (Col-29) epithelia...
  41. ncbi Modulating effects of sensory and autonomic neuropeptides on murine splenocyte proliferation and cytokine secretion induced by Leishmania major
    A A Ahmed
    Department of Dermatology, Karolinska Hospital, Stockholm, Sweden
    Immunopharmacol Immunotoxicol 21:507-26. 1999
    ..b>Calcitonin gene-related peptide enhanced IFN-gamma secretion in susceptible mouse splenocytes at 10(-6), 10(-7) and 10(-9) ..
  42. ncbi Neural regulation of the pulmonary vasculature in a semi-arboreal snake, Elaphe obsoleta
    J A Donald
    Department of Zoology, University of Florida, Gainesville 32611
    J Comp Physiol B 159:677-85. 1990
    ..The distribution of calcitonin gene-related peptide- and SP-LI axons was similar suggesting that the axons are sensory nerves...
  43. ncbi Innervation of the spinal dura. Myth or reality?
    R Kumar
    Department of Neurosurgery, University of Cincinnati College of Medicine, Ohio, USA
    Spine (Phila Pa 1976) 21:18-26. 1996
    ..The posterior longitudinal ligament and peridural membrane were also examined for these elements...
  44. pmc Altered microvascular reactivity to endothelin-1, endothelin-3 and NG-nitro-L-arginine methyl ester in streptozotocin-induced diabetes mellitus
    E Lawrence
    Pharmacology Group, Biomedical Sciences Division, King s College, London
    Br J Pharmacol 106:1035-40. 1992
    ..3 and 3 pmol/site) and vasodilatation to the neuropeptide calcitonin gene-related peptide (CGRP, 1O pmol/site) were similarly reduced in the diabetic rats (P <0.05).5...
  45. ncbi Neuropeptides modulate a murine monocyte/macrophage cell line capacity for phagocytosis and killing of Leishmania major parasites
    A A Ahmed
    Department of Dermatology, Karolinska Hospital, Stockholm, Sweden
    Immunopharmacol Immunotoxicol 23:397-409. 2001
    ..7). The sensory neuropeptides somatostatin (SOM), calcitonin gene-related peptide (CGRP) and substance P (SP) suppressed the macrophage capacity for phagocytosing L...
  46. pmc Impaired sensory-motor nerve function in the isolated mesenteric arterial bed of streptozotocin-diabetic and ganglioside-treated streptozotocin-diabetic rats
    V Ralevic
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 110:1105-11. 1993
    ..Vasodilator responses to exogenously applied calcitonin gene-related peptide, the principal vasodilator transmitter released from these nerves, were not different ..
  47. ncbi Acute cardiovascular and renal effects of human calcitonin gene-related peptide
    C Gennari
    Institute of Medical Semeiotics, University of Siena, Italy
    Am J Hypertens 2:45S-49S. 1989
    Acute cardiovascular and renal effects of 25 micrograms IV human calcitonin gene-related peptide (hCGRP) have been studied in four normotensive and untreated subjects, in the absence and the presence of indomethacin, a prostaglandin ..
  48. pmc Capsaicin-induced relaxation in the rat isolated external urethral sphincter: characterization of the vanilloid receptor and mediation by CGRP
    M Parlani
    Menarini Ricerche Sud, Pharmacology Department, Pomezia, Rome, Italy
    Br J Pharmacol 110:989-94. 1993
    ..3. Capsaicin-induced relaxation of NA-precontracted REUS was mimicked by calcitonin gene-related peptide (CGRP, 0...
  49. pmc Postjunctional inhibitory effect of the NK2 receptor antagonist, SR 48968, on sensory NANC bronchoconstriction in the guinea-pig
    Y P Lou
    Department of Pharmacology, Karolinska Institute, Stockholm, Sweden
    Br J Pharmacol 109:765-73. 1993
    ..However, the same concentration of SR 48968 did not affect the release of neuropeptide calcitonin gene-related peptide (CGRP)-like immunoreactivity (LI) evoked by either vagal stimulation or capsaicin in the ..
  50. pmc Involvement of B1 and B2 receptors in bradykinin-induced rat paw oedema
    M M Campos
    Department of Pharmacology, Universidade Federal de Santa Catarina, , Brazil
    Br J Pharmacol 114:1005-13. 1995
    ..03 +/- 0.01 ml). 3. Co-administration of prostaglandin E2 (PGE2), prostaglandin I2 (PGI2), calcitonin gene-related peptide (CGRP), 5-hydroxytryptamine (5-HT), substance P (SP) or platelet activating factor (PAF) (1 ..
  51. pmc The modulation of inflammatory oedema by calcitonin gene-related peptide
    P Newbold
    Biomedical Sciences Division, King s College, London
    Br J Pharmacol 108:705-10. 1993
    1. The effect of calcitonin gene-related peptide (CGRP) when given with or as a pretreatment to oedema inducing agents was investigated in the skin and paws of male Wistar and Sprague Dawley rats. 2...
  52. ncbi Characterization of thermal hyperalgesia, c-fos expression, and alterations in neuropeptides after mechanical irritation of the dorsal root ganglion
    K Chatani
    Department of Orthopaedic Surgery, Kyoto Prefecture Yosanoumi Hospital, Japan
    Spine (Phila Pa 1976) 20:277-89; discussion 290. 1995
    ..Substance P, calcitonin gene-related peptide, and c-fos expression also were examined in the spinal cord by immunohistochemistry...
  53. ncbi An anatomic study of neuropeptide immunoreactivities in the lumbar dura mater after lumbar sympathectomy
    Y Sekiguchi
    Department of Orthopaedic Surgery, Fukushima Medical College, Japan
    Spine (Phila Pa 1976) 21:925-30. 1996
    ..Density of calcitonin gene-related peptide immunoreactive fibers in sympathectomy side of the lumbar dura mater decreased to 45...
  54. pmc Effects of interactions of naturally-occurring neuropeptides on blood flow in the rat knee joint
    F Y Lam
    Institute of Physiology, University of Glasgow
    Br J Pharmacol 108:694-9. 1993
    ..3. Calcitonin gene-related peptide (CGRP) produced dose-dependent vasodilatation which was more pronounced than that produced ..
  55. pmc An investigation into the mechanism of capsaicin-induced oedema in rabbit skin
    P Newbold
    Pharmacology Group, King s College, London
    Br J Pharmacol 114:570-7. 1995
    ..induced by intradermal histamine (3 nmol) and bradykinin (1 nmol), when in the presence of vasodilator doses of calcitonin gene-related peptide (CGRP) (3 pmol) or prostaglandin E1, (PGE1) (10 pmol), was significantly inhibited (P < ..
  56. ncbi Innervation of the spondylolysis "ligament"
    S M Eisenstein
    Centre for Spinal Studies, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire, United Kingdom
    Spine (Phila Pa 1976) 19:912-6. 1994
    ..Histochemistry involved immunostaining for the neuropeptides: protein gene product, calcitonin gene related peptide, substance P, vasoactive intestinal peptide, and the c-flanking peptide of neuropeptide Y...
  57. ncbi Silver impregnation and immunohistochemical study of nerves in lumbar facet joint plical tissue
    M Gronblad
    Department of Physical Medicine and Rehabilitation, University of Helsinki, Central Hospital, Finland
    Spine (Phila Pa 1976) 16:34-8. 1991
    ..Heterologous antisera to protein gene product (PGP) 9.5, substance P, calcitonin gene-related peptide (CGRP), and galanin were used to stain nerves...
  58. ncbi Symptomatic lumbar spondylolysis. Neuroimmunologic studies
    D Nordstrom
    Fourth Department of Medicine, Helsinki University Central Hospital, Finland
    Spine (Phila Pa 1976) 19:2752-8. 1994
    ..This study characterized the defect using neuroimmunologic and inflammatory cell analysis...
  59. ncbi An immunohistochemical study of innervation of lumbar spinal dura and longitudinal ligaments
    S Kallakuri
    Wayne State University, Bioengineering Center, Detroit, Michigan, USA
    Spine (Phila Pa 1976) 23:403-11. 1998
    ..A population of substance P, calcitonin gene-related peptide, and tyrosine hydroxylase-reactive nerve fibers were observed in all the tissues...
  60. ncbi Action of calcitonin gene-related peptide at the calcitonin receptor of the T47D cell line
    F Raue
    Abteilung Innere Med. I, Endokrinologie und Stoffwechsel, , Germany
    Horm Metab Res 19:563-4. 1987
    Some effects of calcitonin (CT) can also be produced by calcitonin gene-related peptide (CGRP), an alternative product of the calcitonin gene. This might be mediated by interaction of CGRP at the CT-receptor site...
  61. ncbi Whole-body autoradiography of 123I-labelled islet amyloid polypeptide (IAPP). Accumulation in the lung parenchyma and in the villi of the intestinal mucosa in rats
    M Stridsberg
    Department of Clinical Chemistry, University Hospital, Uppsala, Sweden
    Acta Oncol 32:155-9. 1993
    ..in a 37 amino-acid pancreatic islet polypeptide, displaying about 50% amino-acid homology with neuropeptide calcitonin gene-related peptide (CGRP)...
  62. ncbi Lithium inhibits substance P and vasoactive intestinal peptide-induced relaxations on isolated porcine ophthalmic artery
    M B Vincent
    Department of Neurology, Trondheim University Hospital, Norway
    Headache 32:335-9. 1992
    ..of cluster headache and related diseases by liberating neuropeptides such as substance P (SP) and calcitonin gene-related peptide (CGRP) in the eye-forehead region...
  63. ncbi Islet amyloid polypeptide (IAPP). A short review
    M Stridsberg
    Department of Clinical Chemistry, University Hospital, Uppsala, Sweden
    Acta Oncol 30:451-6. 1991
    ..It consists of 37 amino acids and displays about 50% homology with the neuropeptide calcitonin gene-related peptide (CGRP)...
  64. ncbi Modulation of immune function by intestinal neuropeptides
    L P Sirinek
    Department of Pediatrics, Ohio State University, Columbus
    Acta Oncol 30:509-17. 1991
    ..Peptides to be discussed include substance P, somatostatin, vasoactive intestinal peptide (VIP), the opioid peptides leu and met enkephalin, calcitonin gene related peptide (CGRP), neuropeptide Y, and cholecystokinin (CCK).
  65. pmc Hypotensive effect of 13-hydroxylinoleic acid in the rat: mediation via the release of a CGRP-like mediator from capsaicin-sensitive nerves
    D van Heuven Nolsen
    Department of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
    Br J Pharmacol 115:835-9. 1995
    ..5. Ruthenium red (120 micrograms kg-1 min-1), an inhibitor of excitatory effects on sensory nerves, and the CGRP antagonist, CGRP8-37 (1-3 micrograms kg-1 min-1) also inhibited the hypotensive effect of 13-HODE. 6...
  66. pmc Evidence for ETA and ETB receptors in rat skin and an investigation of their function in the cutaneous microvasculature
    E Lawrence
    Biomedical Sciences Division, King s College, London
    Br J Pharmacol 115:840-4. 1995
    ..oedema formation as measured by [125I]-albumin accumulation in the presence or absence of the vasodilator, calcitonin gene-related peptide (CGRP)...
  67. ncbi Sensory and autonomic innervation of the facet joint in the rat lumbar spine
    M Ahmed
    Department of Orthopaedics, Karolinska Hospital, Stockholm, Sweden
    Spine (Phila Pa 1976) 18:2121-6. 1993
    ..Substance P and calcitonin gene-related peptide immunoreactivities, representing sensory nerves, were observed as varicose fibers in the ..
  68. pmc Effect of bradykinin and prostaglandins on the release of calcitonin gene-related peptide-like immunoreactivity from the rat spinal cord in vitro
    L Andreeva
    Sandoz Institute for Medical Research, London
    Br J Pharmacol 108:185-90. 1993
    1. The release of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) from the dorsal horn of the rat spinal cord in vitro in response to dorsal root stimulation was measured by radioimmunoassay. 2...
  69. pmc Current concepts in gastric microcirculatory pathophysiology
    P H Guth
    Medical Service, VA Medical Center West Los Angeles, CA 90073
    Yale J Biol Med 65:677-88. 1992
    ..back-diffusion, and, when this process occurs, signal for a protective increase in blood flow via release of calcitonin gene-related peptide from the submucosal periarteriolar fibers...
  70. ncbi Neuroimmunohistochemical analysis of peridiscal nociceptive neural elements
    Y T Konttinen
    Fourth Department of Medicine, University Central Hospital, Helsinki, Finland
    Spine (Phila Pa 1976) 15:383-6. 1990
    ..presence of neurofilament-positive neural elements containing nociceptive neuropeptides substance P (SP) and/or calcitonin gene-related peptide (CGRP)...
  71. ncbi Innervation of the lumbar facet joints. Origins and functions
    K Suseki
    Department of Orthopaedic Surgery, School of Medicine, Chiba University, Japan
    Spine (Phila Pa 1976) 22:477-85. 1997
    ..The dorsal ramus of the spinal nerve and rami communicantes were connected to each other by calcitonin gene-related peptide immunoreactive fibers and dopamine beta-hydroxylase immunoreactive fibers...
  72. pmc Effect of the tachykinin NK1 receptor antagonists, RP 67580 and SR 140333, on electrically-evoked substance P release from rat spinal cord
    M Malcangio
    Department of Pharmacology, School of Pharmacy, London
    Br J Pharmacol 113:635-41. 1994
    ..3 +/- 2.5 fmol/8 ml, n = 10). 3. RP 67580 (10 nM) did not modify electrically-evoked release of calcitonin gene-related peptide-LI from rat spinal cord slices. 4...
  73. ncbi Joint 1994 Wolff Award Presentation. Peripheral and central trigeminovascular activation in cat is blocked by the serotonin (5HT)-1D receptor agonist 311C90
    P J Goadsby
    Department of Neurology, Prince Henry Hospital, Sydney, NSW, Australia
    Headache 34:394-9. 1994
    ..It has been shown that certain peptides can act as markers for the trigeminal system, in particular calcitonin gene-related peptide (CGRP), and that CGRP is elevated in migraine...
  74. pmc The paradoxical vascular interactions between endothelin-1 and calcitonin gene-related peptide in the rat gastric mucosal microcirculation
    J Lopez Belmonte
    Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent
    Br J Pharmacol 110:496-500. 1993
    1. The interactions between local intra-arterial infusion of endothelin-1 (ET-1) and rat alpha-calcitonin gene-related peptide (alpha-CGRP) on gastric mucosal damage and blood flow have been investigated in the pentobarbitone-..
  75. ncbi Dually innervating nociceptive networks in the rat lumbar posterior longitudinal ligaments
    S Imai
    Department of Orthopaedic Surgery Shiga University of Medical Science, Otsu shi, Japan
    Spine (Phila Pa 1976) 20:2086-92. 1995
    ..METHODS. Rat posterior longitudinal ligaments of whole thickness was immunohistochemically stained for calcitonin gene-related peptide and tyrosine hydroxylase, which have been considered markers of nociceptive and ..
  76. ncbi Direct innervation of sensory fibers from the dorsal root ganglion of the cervical dura mater of rats
    H Yamada
    Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Japan
    Spine (Phila Pa 1976) 23:1524-9; discussion 1529-30. 1998
    ..Some calcitonin gene-related peptide immunoreactive fibers in the dorsal root ganglion were directly innervated from dorsal root ..
  77. ncbi Influence of peripheral targets on the expression of calcitonin gene-related peptide immunoreactivity in rat cranial motoneurones
    P N McWilliam
    Institute for Cardiovascular Research, Research School of Medicine, University of Leeds, United Kingdom
    J Neurobiol 28:506-14. 1995
    b>Calcitonin gene-related peptide-like immunoreactivity (CGRP-ir) is displayed by motoneurons that innervate striated muscle but is absent from preganglionic parasympathetic motoneurons...
  78. pmc Effect of a calcitonin gene-related peptide antagonist (CGRP8-37) on skin vasodilatation and oedema induced by stimulation of the rat saphenous nerve
    K J Escott
    Division of Biomedical Sciences, King s College, London
    Br J Pharmacol 110:772-6. 1993
    1. The effect of the calcitonin gene-related peptide antagonist (CGRP8-37, 400 nmol kg-1, i.v...
  79. pmc Regional haemodynamic effects of human and rat adrenomedullin in conscious rats
    S M Gardiner
    Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen s Medical Centre
    Br J Pharmacol 114:584-91. 1995
    ..to compare the responses to human adrenomedullin to those of human alpha-CGRP in the absence and presence of the CGRP1-receptor antagonist, human alpha-CGRP [8-37], and to determine the involvement of nitric oxide (NO)-mediated ..
  80. ncbi Calciotropic hormones in human and experimental hypertension
    L M Resnick
    Cardiovascular Center, New York Hospital, Cornell Medical Center, New York
    Am J Hypertens 3:171S-178S. 1990
    ..Recent research provides evidence that parathyroid hormone, calcitonin, 1,25-dihydroxyvitamin D, as well as newly described factors such as calcitonin gene-related peptide (CGRP), ..
  81. ncbi Sensory innervation of the lumbar dura mater passing through the sympathetic trunk in rats
    Y Konnai
    Departments of Orthopaedic Surgery and Anatomy, Fukushima Medical College, Fukushima, and the Department of Anatomy, Nagoya University School of Medicine, Nagoya, Japan
    Spine (Phila Pa 1976) 25:776-82. 2000
    ..To establish the sensory property, the materials were processed in immunohistochemistry for calcitonin gene-related peptide...
  82. pmc In vivo pharmacological characterization of the non-peptide endothelin receptor antagonist SB 209670
    S A Douglas
    Department of Cardiovascular, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406 0939
    Br J Pharmacol 114:405-13. 1995
    ..The haemodynamic actions of angiotensin II and calcitonin gene-related peptide were unaltered by 100 micrograms kg-1 min-1 (+/-)-SB 209670. 4. Bolus i.v...
  83. doi Modulation of nocioceptive transmission with calcitonin gene-related peptide receptor antagonists in the thalamus
    Oliver Summ
    Headache Group Department of Neurology, University of California San Francisco, 1701 Divisadero St, San Francisco, CA 94115, USA
    Brain 133:2540-8. 2010
    b>Calcitonin gene-related peptide receptor antagonists are effective acute migraine treatments without the vascular contraindications associated with triptans...
  84. doi Colonic vascular conductance increased by Daikenchuto via calcitonin gene-related peptide and receptor-activity modifying protein 1
    Toru Kono
    Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical College, Hokkaido, Japan
    J Surg Res 150:78-84. 2008
    ..DKT may increase gastrointestinal motility by an up-regulation of the calcitonin gene-related peptide (CGRP). CGRP is also the most powerful vasoactive substance...
  85. doi Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion
    S Eftekhari
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
    Neuroscience 169:683-96. 2010
    b>Calcitonin gene related peptide (CGRP) has a key role in migraine and recently CGRP receptor antagonists have demonstrated clinical efficacy in the treatment of migraine...
  86. ncbi The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression
    Alex C Conner
    School of Life and Health Sciences, Aston University, Birmingham B4 7ET, United Kingdom
    J Biol Chem 281:1644-51. 2006
    The calcitonin gene-related peptide (CGRP) receptor is a heterodimer of a family B G-protein-coupled receptor, calcitonin receptor-like receptor (CLR), and the accessory protein receptor activity modifying protein 1...
  87. doi Novel peptide antagonists of adrenomedullin and calcitonin gene-related peptide receptors: identification, pharmacological characterization, and interactions with position 74 in receptor activity-modifying protein 1/3
    Samuel D Robinson
    School of Biological Sciences, University of Auckland, Auckland, New Zealand
    J Pharmacol Exp Ther 331:513-21. 2009
    Human adrenomedullin (AM) is a 52-amino acid peptide belonging to the calcitonin peptide family, which also includes calcitonin gene-related peptide (CGRP) and AM2...
  88. ncbi Deletions of genes encoding calcitonin/alpha-CGRP, amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors and calcitonin receptor-like receptors in bone
    U H Lerner
    Department of Oral Cell Biology, Umea University, Umea, Sweden
    J Musculoskelet Neuronal Interact 6:87-95. 2006
    ..Recently, gene deletion experiments have shown that calcitonin gene-related peptide (CGRP), one of the neuropeptides present in skeletal nerve fibers, is an important ..
  89. ncbi Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes
    Jaesook Roh
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    J Biol Chem 279:7264-74. 2004
    b>Calcitonin, calcitonin gene-related peptide (CGRP), adrenomedullin (ADM), and amylin belong to a unique group of peptide hormones important for homeostasis in diverse tissues...
  90. doi The influence of brain injury or peripheral nerve injury on calcitonin gene-related peptide concentration variation and fractures healing process
    Dianying Zhang
    Department of Trauma Orthopedics, People s Hospital, Peking University, Beijing, China
    Artif Cells Blood Substit Immobil Biotechnol 37:85-91. 2009
    To investigate the changes of calcitonin gene-related peptide (CGRP) in rat's blood plasma, spinal anterior motorneuron, and dorsal root ganglion (DRG) after fractures combined with central or peripheral nerve injuries and its influence ..
  91. doi Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function
    Tao Qi
    School of Biological Sciences, University of Auckland, Symonds Street, Auckland, New Zealand
    Mol Pharmacol 74:1059-71. 2008
    b>Calcitonin-family receptors comprise calcitonin receptor-like receptor (CL) or calcitonin receptor and receptor activity-modifying protein (RAMP) pairings...
  92. pmc Involvement of multiple receptors in the biological effects of calcitonin gene-related peptide and amylin in rat and guinea-pig preparations
    S Giuliani
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 107:510-4. 1992
    1. The activity of rat alpha and beta calcitonin gene-related peptide (CGRP) as compared to the structurally related peptide, rat amylin, has been investigated in the guinea-pig isolated left atrium (electrically driven), in mucosa-free ..
  93. ncbi An ultrastructural study of calcitonin gene-related peptide-immunoreactive nerve fibers innervating the rat posterior longitudinal ligament. A morphologic basis for their possible efferent actions
    S Imai
    Department of Anatomy, University of Helsinki, Finland
    Spine (Phila Pa 1976) 22:1941-7. 1997
    STUDY DESIGN: The present study investigated ultrastructural characteristics of calcitonin gene-related peptide-immunoreactive nerve fibers in the posterior longitudinal ligament of the rat lumbar spine...
  94. ncbi Neonatal sciatic nerve section results in thiamine monophosphate but not substance P or calcitonin gene-related peptide depletion from the terminal field in the dorsal horn of the rat: the role of collateral sprouting
    M L Reynolds
    Department of Anatomy and Developmental Biology, University College London, U K
    Neuroscience 51:191-202. 1992
    The expression of substance P, calcitonin gene-related peptide (CGRP) and thiamine monophosphatase in the sciatic nerve terminal field of the lumbar dorsal horn of the rat was examined following neonatal sciatic nerve section and ligation...
  95. ncbi Calcitonin gene-related peptide receptor expression in the neurons and glia of developing rat cerebellum: an autoradiographic and immunohistochemical analysis
    S Morara
    Istituto Neuroscienze e Bioimmagini CNR, 20131, Milano, Italy
    Neuroscience 100:381-91. 2000
    Quantitative autoradiography (using [125I]human alpha-calcitonin gene-related peptide as a ligand) and immunofluorescence (using monoclonal antibodies directed against a purified receptor) followed by confocal analysis were applied to ..
  96. doi Calcitonin gene related peptide (CGRP) inhibits norepinephrine induced apoptosis in cultured rat cardiomyocytes not via PKA or PKC pathways
    Fu Ping Zhao
    Department of Anesthesiology, Shanxi Medical University, Taiyuan, Shanxi, China
    Neurosci Lett 482:163-6. 2010
    Evidence showed overrelease of norepinephrine can induce apoptosis in ventricle myocytes. Calcitonin gene related peptide and norepinephrine could be simultaneously up-regulated in early time of acute myocardial ischemia, suggesting a co-..
  97. ncbi Functional calcitonin gene-related peptide subtype 2 receptors in porcine coronary arteries are identified as calcitonin gene-related peptide subtype 1 receptors by radioligand binding and reverse transcription-polymerase chain reaction
    B R Rorabaugh
    Department of Pharmacology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Pharmacol Exp Ther 299:1086-94. 2001
    b>Calcitonin gene-related peptide (CGRP) receptors are classified into CGRP subtype 1 (CGRP(1)) and CGRP subtype 2 (CGRP(2)) based on the affinity of the antagonist, human alpha (halpha)-CGRP(8-37)...
  98. ncbi Changes in the mRNA expression pattern, with special reference to calcitonin gene-related peptide, after axonal injuries in rat motoneurons depends on age and type of injury
    F Piehl
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Exp Brain Res 119:191-204. 1998
    ..after a peripheral nerve transection in the adult animal is characterized by a robust upregulation of alpha-calcitonin gene-related peptide (CGRP) messenger RNA (mRNA) together with mRNAs encoding cytoskeletal and growth-related ..
  99. pmc Levels of vasoactive intestinal peptide, cholecystokinin and calcitonin gene-related peptide in plasma and jejunum of rats following traumatic brain injury and underlying significance in gastrointestinal dysfunction
    Chun Hua Hang
    Department of Neurosurgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China
    World J Gastroenterol 10:875-80. 2004
    ..To study the alterations of brain-gut peptides following traumatic brain injury (TBI) and to explore the underlying significance of these peptides in the complicated gastrointestinal dysfunction...
  100. ncbi Effects of calcitonin gene-related peptide on apoptosis of peripheral blood mononuclear cells from patients with systemic lupus erythematosus
    C Liu
    Department of Dermatology, Affiliated Hospital of Yunyang Medical College, Shiyan, China
    Clin Exp Dermatol 32:650-3. 2007
    Systemic lupus erythematosus (SLE) is an autoimmune disease with abnormal apoptosis and autoantibody production. Calcitonin gene-related peptide (CGRP) is a neuropeptide produced by the central and peripheral nervous systems and by ..
  101. ncbi Phenotypic inflammation switch in rats shown by calcitonin gene-related peptide immunoreactive dorsal root ganglion neurons innervating the lumbar facet joints
    S Ohtori
    Third Department of Anatomy, School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 26:1009-13. 2001
    ..the L5-L6 facet joint were studied using the retrograde neurotransport method and the immunohistochemistry of calcitonin gene-related peptide in an inflammatory model of rats...

Research Grants65

  1. NICOLE LEANNE WARD; Fiscal Year: 2014
    ..provided by applicant): Psoriatic skin contains more nerve fibers and increased levels of sensory nerve-derived calcitonin gene related peptide (CGRP) and substance P (SP)...
  2. Rodger A Liddle; Fiscal Year: 2016
    ..vasodilation, plasma extravasation, and pain and is due largely to release of the neuropeptides substance P and calcitonin gene-related peptide (CGRP)...
  3. Spinal Cord-Mediated Acute Neurogenic Inflammation
    Qing Lin; Fiscal Year: 2010
    ..determine if neurogenic inflammation following CAP injection involves triggering DRRs that cause the release of calcitonin gene-related peptide and/or substance P from primary afferent nociceptors and if this process would in turn ..
  4. The role of BNST CGRP in stress-enhanced anxiety behavior and HPA-axis function
    Kelly S Sink; Fiscal Year: 2013
    ..as an important component of stress regulation circuitry, contains dense terminals that release the neuropeptide calcitonin gene-related peptide (CGRP)...
  5. Mechanisms of airway neurogenic inflammation by asthma-inducing allergens
    Armen N Akopian; Fiscal Year: 2013
    ..One of the possibilities is that neuropeptides such as substance P (SP) and calcitonin gene-related peptide (CGRP), which trigger neurogenic inflammation, could be released from sensory nerve ..
  6. Andrew F Russo; Fiscal Year: 2015
    ..DESCRIPTION (provided by applicant): Migraine is a debilitating neurological condition involving the neuropeptide calcitonin gene-related peptide (CGRP)...
  7. NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATION
    Eileen Grady; Fiscal Year: 2006
    This proposal examines the general hypothesis that the neuropeptides substance P (SP) and calcitonin-gene related peptide (CGRP) act in a co-operative fashion to induce neurogenic inflammation of the intestine...
  8. Ontogeny of CRLR and RAMPs in Myometrium
    Chandrasekhar Yallampalli; Fiscal Year: 2002
    ..In the absence or imbalance of these molecules within the uterus, fetus will be delivered prematurely. Calcitonin gene-related peptide (CGRP) is the most potent smooth muscle relaxant peptide known, and is also a major ..
  9. Liya Qiao; Fiscal Year: 2016
    ..including Ca2+/calmodulin-dependent protein kinase (CaMK)II, cAMP-response element binding protein (CREB), calcitonin gene-related peptide (CGRP), and cerebellin 1 precursor (Cbln1) in bladder afferent neurons before and during ..
  10. Treat Neuropathic Pain with Dissolvable Microneedles Containing Anti-CGRP Peptide
    Xinmin Simon Xie; Fiscal Year: 2013
    ..b>Calcitonin Gene-Related Peptide (CGRP) appears to be critical in this process...
  11. John R Grider; Fiscal Year: 2016
    ..are present in mucosal enteroendocrine cells that contain serotonin (5-HT) and sensory neurons containing calcitonin gene-related peptide (CGRP) and substance P (SP), and that BDNF acts to enhance 5-HT and CGRP release in ..
  12. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    JOHN GRIDER; Fiscal Year: 2009
    ..are present in mucosal enteroendocrine cells that contain serotonin (5-HT) and sensory neurons containing calcitonin gene-related peptide (CGRP) and substance P (SP), and that BDNF acts to enhance 5-HT and CGRP release in ..
  13. Wade S Kingery; Fiscal Year: 2015
    ..The project's specific aims are as follows: 1. We will test the hypothesis that substance P (SP), calcitonin gene related peptide (CGRP) and beta 2 adrenergic receptor agonists stimulate the production of key inflammasome ..
  14. Mark W Chapleau; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Calcitonin gene-related peptide (CGRP) functions as an autocrine/paracrine factor, hormone and neuro- modulator...
  15. The role of stress and mast cells in a preclinical mouse model of migraine
    ANN CHRISTINE RADDANT; Fiscal Year: 2013
    ..b>Calcitonin gene-related peptide (CGRP) plays a critical role in migraine, as evidenced by recent success of CGRP ..
  16. Coronary Dysregulation Associated with Obesity
    Christine L Oltman; Fiscal Year: 2013
    ..b>Calcitonin gene-related peptide (CGRP) is a very potent physiological microvascular dilator...
  17. Human Fetoplacental Vasculature and CGRP
    Yuan Lin Dong; Fiscal Year: 2005
    ..b>Calcitonin gene-related peptide (CGRP) has been demonstrated to be involved in the regulation of blood pressure and ..
  18. Prevention of Diabetic Neuropathy with ACE Inhibitors
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..NEP degrades natriuretic peptides as well as neuropeptides such as calcitonin gene-related peptide (CGRP) and bradykinin...
  19. NEURONAL CONTROL OF CGRP GENE EXPRESSION
    ANDREW RUSSO; Fiscal Year: 2009
    b>Calcitonin gene-related peptide (CGRP) has been implicated in craniofacial pain and headache by virtue of its expression in the trigeminal ganglion and roles in neurogenic inflammation and nociception...
  20. Chandrasekhar Yallampalli; Fiscal Year: 2016
    ..Peptides of the calcitonin gene-related peptide (CGRP)-family-CGRP, adrenomedullin (AM), and intermedin (IMD)-have been shown to play ..
  21. The Responses of Thermoregulatory Neurons to CGRP
    John Griffin; Fiscal Year: 2009
    ..This transient hyperthermic shift in body temperature has been linked to the neuropeptide calcitonin gene-related peptide (CGRP), which acts peripherally to increase vasodilation and centrally to increase ..
  22. Kalpaj Parekh; Fiscal Year: 2015
    ..Specifically, this proposal will focus on the contribution of denervation to aberrant calcitonin gene related peptide (CGRP) neuropeptide responses that control stem cell proliferation in the airways...
  23. Marjan Boerma; Fiscal Year: 2014
    ..hormone that is formed by mast cell proteinases;and 3) the cardioprotective sensory neuropeptide calcitonin gene-related peptide (CGRP), as part of the neuroimmune interactions that are known to alter cardiac function ..
  24. INDUCIBLE ALTERATION OF CGRP IN PRIMARY AFFERENT NEURONS
    KARIN WESTLUND HIGH; Fiscal Year: 1993
    ..to test the existence of inducible alterations in peptide content in primary afferent/autonomic pathways calcitonin gene-related peptide (CGRP)...
  25. Mouse model of vestibulodynia using recurrent vulvovaginal Candidiasis
    MELISSA ANNE FARMER; Fiscal Year: 2010
    ..5 immunohistochemistry) and markers of nociception (via calcitonin gene related peptide and the vanilloid receptor TRPV1);(c) to examine the immunological profile of vulvar tissue ..
  26. DYNORPHIN MODULATES CGRP RELEASE VIA PKC
    Zaijie Jim Wang; Fiscal Year: 2003
    ..Both dynorphin and activation of PKC were found to augment capsaicin-evoked calcitonin gene-related peptide (CGRP) release, characteristic of activation of primary afferent fibers...
  27. Natasha N Chattergoon; Fiscal Year: 2016
    ..We determined that calcitonin gene-related peptide, a powerful vasodilator, is potent inhibitor of VSMC proliferation in vitro by stimulating ..
  28. Role of TRP Channels in Environmental Irritant-Induced Headache
    Gerry S Oxford; Fiscal Year: 2013
    ..TRPA1 homomers, or TRPA1/TRPV1 heteromers on trigeminal neurons innervating the meninges results in release of calcitonin gene-related peptide (CGRP), a potent vasodilator implicated in migraine...
  29. Augen A Pioszak; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The human calcitonin (CTR) and calcitonin-like (CLR) receptors are cell-surface class B G protein-coupled receptors (GPCRs) that associate with receptor activity modifying protein (RAMP) co-receptors ..
  30. Ethanol Prevents Microvascular Dysfunction
    Ronald J Korthuis; Fiscal Year: 2010
    ..of an anti-inflammatory phenotype by stimulating the formation of eNOS-derived NO;(2) NO-induced release of calcitonin gene-related peptide (CGRP) plays an essential role in the acquisition of tolerance to ischemia that is evoked ..
  31. Lorenzo Cohen; Fiscal Year: 2015
    ..on saliva based factors including pH, buffering capacity, and viscosity as well as levels of total protein, calcitonin- gene-related peptide (CGRP), and vasoactive intestinal polypeptide (VIP);and 6...
  32. AMY-1 receptors: Novel targets for antipsychotic development
    Brian A Baldo; Fiscal Year: 2012
    ..This receptor binds members of the calcitonin family of peptides, including amylin, salmon calcitonin, and calcitonin gene-related peptide (CGRP)...
  33. Role of CGRP in the association between migraine and obesity
    ANA RECOBER-MONTILLA; Fiscal Year: 2013
    ..The objective of this proposal is to test the concept that calcitonin gene-related peptide (CGRP) represents a biological link between obesity and migraine...
  34. Genetic targeting of CGRP actions in a murine model of migraine
    ERIC ALAN KAISER; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Migraine is a highly prevalent and disabling neurological pain disorder. Calcitonin gene-related peptide (CGRP) is now strongly implicated in migraine;however, its exact role in the pathophysiology of ..
  35. Intermedin / AM2 in Human Pregnancy
    MADHU LATA CHAUHAN; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Calcitonin (CT), calcitonin gene related peptide CGRP, amylin and adrenomedullin (AM) belong to a unique group of peptide, hormones, important for homeostasis...
  36. REGULATION OF ALTERNATIVE PROCESSING OF CALCITONIN/CGRP
    Susan Berget; Fiscal Year: 2002
    ..The gene under study is that coding for the peptide hormones calcitonin (CT) and calcitonin-gene-related peptide (CGRP)...
  37. CALCITONIN GENE-RELATED PEPTIDE IN HYPERTENSION
    Gianfranco Alpini; Fiscal Year: 2006
    ..This efferent function is mediated by the release of neuropeptides, such as CGRP and substance P (SP)...
  38. CONTROL OF NEUROENDOCRINE GENE EXPRESSION
    STUART LEFF; Fiscal Year: 1992
    ..project proposes to study the mechanisms by which cell- specific expression of the neuro- and endocrine peptides calcitonin and calcitonin gene-related peptide (CGRP) is determined at a transcriptional and post-transcriptional level...
  39. CALCITONIN GENE RELATED PEPTIDE AND AGING
    PANDU GANGULA; Fiscal Year: 2000
    ..We propose that the calcitonin gene-related peptide (CGRP) plays a critical role in such mechanisms...
  40. CONTROL OF NEUROENDOCRINE GENE EXPRESSION
    STUART LEFF; Fiscal Year: 1993
    ..This project proposes to study the mechanism by which cell-specific expression of the neuro-and endocrine peptides calcitonin and calcitonin gene-related peptide (CGRP) is determined at a transcriptional and post- transcriptional level...
  41. PROTEIN ENGINEERING - PEPTIDE HORMONE DESIGN
    John Taylor; Fiscal Year: 1993
    ..Neuropeptide Y (NPY), calcitonin and calcitonin gene related peptide (CGRP) will serve as examples where there is already good evidence that ..
  42. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
    ..increases the number of trigeminal ganglion (TG) muscle afferent neurons that express: substance P (SP), calcitonin gene-related peptide (CGRP), neurokinin-1 receptor (NK-lr) and CGRP receptor (CGRPr)...
  43. Efferent Signaling through the CGRP receptor complex
    RHIANNON BUSSEY; Fiscal Year: 2007
    ..The olivocochlear (OC) efferent system is composed of medial (M) OC and lateral (L) OC fibers. Calcitonin gene-related peptide (CGRP) is released from LOG fibers onto spiral ganglion fibers and inner hair cells ..
  44. Molecular Mechanisms Critical to CGRP Receptor Signaling
    James Porter; Fiscal Year: 2003
    ..The neuromodulator, calcitonin gene-related peptide (CGRP) is released from peripheral and central nerve terminals upon sensory activation...
  45. Inflammatory Signaling Mechanisms of the CGRP Receptor
    James Porter; Fiscal Year: 2004
    ..The immediate goal of this project is to characterize signaling pathways initiated by calcitonin gene-related peptide (CGRP) receptor activation that lead to increased production of pro-inflammatory compounds...
  46. BRAIN REGULATING GASTRIC ACID FUNCTION BY NEUROPEPTIDES
    YVETTE TACHE; Fiscal Year: 2000
    ..vagal cholinergic gastric hyperemic response to central injection of TRH was shown to be mediated by capsaicin- calcitonin gene-related peptide (CGRP) and nitric oxide dependent mechanisms...
  47. Melanopsin Signal Transduction Studied by FTIR Spectroscopy
    Kenneth J Rothschild; Fiscal Year: 2012
    ..Prominent examples include serotonin, histamine, adrenergic, muscarinic and calcitonin receptors which are targets of current and potentially new drugs...
  48. MOLECULAR BASIS OF VESTIBULAR EFFERENT FUNCTION
    P Wackym; Fiscal Year: 1999
    ..neurotransmitter acetylcholine, represented by choline acetyltransferase (CHAT), the efferent neuromodulator calcitonin gene- related peptide (CGRP): and the nicotinic (nAChR) and muscarinic (mAChR) acetylcholine receptors in the ..
  49. ORGANIZATION AND EXPRESSION OF CGRP IN THE PANCREAS
    Catia Sternini; Fiscal Year: 1991
    In our previous studies we have demonstrated the presence of calcitonin gene-related peptide (CGRP) immunoreactivity in nerve fibers in the rat pancreas innervating the acini, ducti, blood vessels and islets of Langerhans as well as in a ..
  50. CGRP IN SUBARACHNOID HEMORRHAGE
    ANDREW RUSSO; Fiscal Year: 2001
    DESCRIPTION Release of calcitonin gene-related peptide (CGRP) from trigeminal sensory fibers is a potent vasodilator mechanism in the cerebral circulation...
  51. CGRP CONTROL OF HUMAN MYOMETRIAL CONTRACTILITY
    Yuan Lin Dong; Fiscal Year: 2001
    ..b>Calcitonin gene-related peptide (CGRP) has been demonstrated to be involved in the regulation of blood pressure and ..
  52. MECHANISMS REGULATING ATRIOPEPTIN SECRETION
    Rick Schiebinger; Fiscal Year: 1991
    ..Using this technique the following hypotheses will be tested. 1) Calcitonin gene-related peptide (CGRP) and neuropeptide Y (NP-Y), which are located in atrial nerve fibers, influence ANP ..
  53. Functional role of CGRP as an efferent neurotransmitter
    Colleen Le Prell; Fiscal Year: 2007
    ..Recently, Maison et al. (2003) presented evidence that calcitonin-gene-related peptide (CGRP) could modulate the excitatory LOC effects observed in the above investigations...
  54. CGRP, NO, AND SEPSIS INDUCED MICROVASCULAR DYSFUNCTION
    WARWICK ARDEN; Fiscal Year: 2002
    ..The investigator focuses on the role of the potent vasoactive neuropeptide calcitonin gene-related peptide (CGRP) in resistant artery dysfunction in endotoxin-induced circulatory shock...
  55. Kathleen M Caron; Fiscal Year: 2016
    ..peptide vasodilator adrenomedullin (AM) typically signals through a G-protein coupled receptor (GPCR) called calcitonin receptor-like receptor (Calcrl) when the receptor is bound to a novel class of proteins called receptor activity ..
  56. Role of RAMPs in Intermedin Signaling
    Sheau Yu Teddy Hsu; Fiscal Year: 2010
    ..Functional studies showed that intermedin signals through a G protein-coupled receptor, calcitonin receptor-like receptor (CLR)...
  57. Michael Nitabach; Fiscal Year: 2016
    ..signal through cAMP in fly circadian/sleep control circuits: PDF (Pigment Dispersing Factor), DH31 (fly calcitonin homologue), and DH44 (fly corticotropin releasing factor (CRF) homologue)...
  58. CALCITONIN RECEPTOR GENE EXPRESSION
    Steven Goldring; Fiscal Year: 2002
    Our initial application proposed to study the mechanism of action and regulation of the calcitonin receptor (CTR) gene...
  59. REGULATION OF THE MURINE CALCITONIN RECEPTOR GENE
    DEBORAH GALSON; Fiscal Year: 2001
    DESCRIPTION (adapted from the Investigator's abstract): Calcitonin (CT) was originally identified as an endocrine hormone that lowers extracellular calcium by inhibiting osteoclastic bone resorption and enhancing renal calcium excretion...
  60. Controlled delivery of polypeptide hormone calcitonin
    Jagdish Singh; Fiscal Year: 2013
    ..b>Calcitonin isa polypeptide hormone with 32 amino acids and has a molecular mass of about 3500...
  61. METHYLATION OF THE CALCITONIN GENE IN HUMAN TUMORS
    Stephen B Baylin; Fiscal Year: 2013
    ..We investigate whether this change can foster cancer initiation and the molecular mechanisms though which it arises. ..
  62. Calcitonin in Prostate Growth and Neplasia
    Girish V Shah; Fiscal Year: 2013
    ..We and others have shown that all primary PCs and PC cell lines express calcitonin (CT) and/or its receptor (CTR), and their co-expression positively correlates with the tumor grade of primary ..
  63. Characterization of Neuroendocrine CGRP Receptors
    Ian Dickerson; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): We have discovered a 148 aa protein named calcitonin gene-related peptide (CGRP)-receptor component protein (RCP) that is required for G protein-coupled signal transduction at receptors ..
  64. Regulation of B Cell Development by Neuropeptides
    JOSEPH MCGILLIS; Fiscal Year: 2005
    ..The focus of this project is on the role of the neuropeptide calcitonin- gene related peptide (CGRP) in regulating early B cell differentiation...
  65. SYMPATHETIC FIBER MODULATION OF NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2003
    ..inflammation, as measured by reduction of capsaicin-evoked release of the pro-inflammatory neuropeptide calcitonin gene-related peptide (CGRP) from superfused dental pulp...

Patents1

  1. Biologically active peptides
    Patent Number: EP0070186-A1; Date:1983-01-19