CA9

Summary

Gene Symbol: CA9
Description: carbonic anhydrase 9
Alias: CAIX, carbonic anhydrase 9, CA-IX, P54/58N, RCC-associated antigen G250, RCC-associated protein G250, carbonate dehydratase IX, carbonic anhydrase IX, carbonic dehydratase, membrane antigen MN, pMW1, renal cell carcinoma-associated antigen G250
Species: human

Top Publications

  1. ncbi Expression of MaTu-MN protein in human tumor cultures and in clinical specimens
    J Zavada
    Institute of Virology, Slovak Academy of Sciences, Bratislava
    Int J Cancer 54:268-74. 1993
  2. pmc Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes
    S V Ivanov
    Intramural Research Support Program, Science Applications International Corporation Frederick, Laboratory of Immunobiology, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 95:12596-601. 1998
  3. ncbi Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma
    Karin Grabmaier
    Laboratory for Experimental Urology, 190 RT NCMLS, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Oncogene 23:5624-31. 2004
  4. ncbi Tumor carbonic anhydrase 9 expression is associated with the presence of lymph node metastases in uterine cervical cancer
    Sun Lee
    Radiation Oncology, National Cancer Center, 809 Madu dong, Ilsan gu, Goyang si, Gyeonggi Do, 411 769, Korea
    Cancer Sci 98:329-33. 2007
  5. ncbi Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer
    Anssi M Niemelä
    Department of Surgery, Jyvaskyla Central Hospital, Keskussairaalantie 19, 40620 Jyvaskyla, Finland
    Cancer Epidemiol Biomarkers Prev 16:1760-6. 2007
  6. doi Phosphorylation of signal transducer and activator of transcription 3 (STAT3) correlates with Her-2 status, carbonic anhydrase 9 expression and prognosis in esophageal cancer
    Sebastian F Schoppmann
    Department of Surgery, Cancer Comprehensive Center Vienna, University of Vienna, Waehringer Guertel 18 20, 1090, Vienna, Austria
    Clin Exp Metastasis 29:615-24. 2012
  7. ncbi Carbonic anhydrase IX, hypoxia-inducible factor-1α, ezrin and glucose transporter-1 as predictors of disease outcome in rectal cancer: multivariate Cox survival models following data reduction by principal component analysis of the clinicopathological pre
    Eija A Korkeila
    Department of Oncology and Radiotherapy, Turku University Hospital, Hämeentie 11, PB 52, FIN 20521 Turku, Finland
    Anticancer Res 31:4529-35. 2011
  8. doi Hypoxia-related molecules HIF-1α, CA9, and osteopontin : predictors of survival in patients with high-grade glioma
    O P Erpolat
    Department of Radiation Oncology, Medical School of Gazi University, Ankara, Turkey
    Strahlenther Onkol 189:147-54. 2013
  9. pmc The role of Hypoxia-inducible factor-1 α , glucose transporter-1, (GLUT-1) and carbon anhydrase IX in endometrial cancer patients
    Pawel Sadlecki
    Department of Obstetrics and Gynecology, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University of Torun, Ulica Ujejskiego 75, 85 168 Bydgoszcz, Poland
    Biomed Res Int 2014:616850. 2014
  10. pmc Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas
    N Burrows
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
    Endocr Relat Cancer 17:61-72. 2010

Research Grants

  1. Susan Cooke Frost; Fiscal Year: 2016
  2. 124I-cG250 ImmunoPET Imaging of Sunitinib Treatment Response in Renal Cell Cancer
    STEVEN MARK LARSON; Fiscal Year: 2012
  3. Eugene D Kwon; Fiscal Year: 2014
  4. Huan Xie; Fiscal Year: 2015
  5. The Role of Nutrition in Virus-Induced Optic Neuropathy
    Melinda Beck; Fiscal Year: 2006
  6. Single Cell Analysis of Cross Talk Among Kinase Pathways
    Stefan Kaluz; Fiscal Year: 2008
  7. QUANTITATION OF HYPOXIC TUMOR CELLS
    Peggy Olive; Fiscal Year: 2001
  8. Phase II Study of 44Gy from 131I-81C6 for CNS Tumors
    David Reardon; Fiscal Year: 2004
  9. Role of Cystatins in Oral Cancer Metastasis
    Nadarajah Vigneswaran; Fiscal Year: 2007

Detail Information

Publications214 found, 100 shown here

  1. ncbi Expression of MaTu-MN protein in human tumor cultures and in clinical specimens
    J Zavada
    Institute of Virology, Slovak Academy of Sciences, Bratislava
    Int J Cancer 54:268-74. 1993
    ..Using immunogold-staining, we visualized the p54/58N on the surface microvilli and in the nucleus, particularly in nucleoli...
  2. pmc Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes
    S V Ivanov
    Intramural Research Support Program, Science Applications International Corporation Frederick, Laboratory of Immunobiology, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 95:12596-601. 1998
    ..Additional experiments are needed to define the role of CA IX and CA XII enzymes in the regulation of pH in the extracellular microenvironment and its potential impact on ..
  3. ncbi Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma
    Karin Grabmaier
    Laboratory for Experimental Urology, 190 RT NCMLS, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Oncogene 23:5624-31. 2004
    ..and band-shift analysis demonstrated that Sp1 and HIF-1alpha proteins in nuclear extracts of RCC cells bind to the CAIX promoter and mutations in the most proximal Sp1 binding element or HIF binding element completely abolished CAIX ..
  4. ncbi Tumor carbonic anhydrase 9 expression is associated with the presence of lymph node metastases in uterine cervical cancer
    Sun Lee
    Radiation Oncology, National Cancer Center, 809 Madu dong, Ilsan gu, Goyang si, Gyeonggi Do, 411 769, Korea
    Cancer Sci 98:329-33. 2007
    ..b>CA9/CA12 expression was evaluated histochemically in primary cervical cancer tissues of 73 patients who underwent ..
  5. ncbi Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer
    Anssi M Niemelä
    Department of Surgery, Jyvaskyla Central Hospital, Keskussairaalantie 19, 40620 Jyvaskyla, Finland
    Cancer Epidemiol Biomarkers Prev 16:1760-6. 2007
    Carbonic anhydrase (CA) II, CA IX, and CA XII are expressed in various neoplasias and have been linked to tumorigenesis. We examined their expression in three different groups of colorectal cancer [i.e...
  6. doi Phosphorylation of signal transducer and activator of transcription 3 (STAT3) correlates with Her-2 status, carbonic anhydrase 9 expression and prognosis in esophageal cancer
    Sebastian F Schoppmann
    Department of Surgery, Cancer Comprehensive Center Vienna, University of Vienna, Waehringer Guertel 18 20, 1090, Vienna, Austria
    Clin Exp Metastasis 29:615-24. 2012
    ..STAT3 also regulates carbonic anhydrase IX (CAIX) expression in vivo, promoting IL-6-dependent tumor invasion...
  7. ncbi Carbonic anhydrase IX, hypoxia-inducible factor-1α, ezrin and glucose transporter-1 as predictors of disease outcome in rectal cancer: multivariate Cox survival models following data reduction by principal component analysis of the clinicopathological pre
    Eija A Korkeila
    Department of Oncology and Radiotherapy, Turku University Hospital, Hämeentie 11, PB 52, FIN 20521 Turku, Finland
    Anticancer Res 31:4529-35. 2011
    Strong expression of carbonic anhydrase IX (CAIX), hypoxia-inducible factor-1α (HIF-1α), ezrin and glucose transporter-1 (GLUT-1) was previously shown to be related to adverse disease outcome in rectal cancer...
  8. doi Hypoxia-related molecules HIF-1α, CA9, and osteopontin : predictors of survival in patients with high-grade glioma
    O P Erpolat
    Department of Radiation Oncology, Medical School of Gazi University, Ankara, Turkey
    Strahlenther Onkol 189:147-54. 2013
    A high expression of hypoxia-inducible factor-1 alpha (HIF)-1α, carbonic anhydrase 9 (CA9), and osteopontin appears to be a strong prognostic indicator in many malignancies; however, their role is unclear in high-grade gliomas.
  9. pmc The role of Hypoxia-inducible factor-1 α , glucose transporter-1, (GLUT-1) and carbon anhydrase IX in endometrial cancer patients
    Pawel Sadlecki
    Department of Obstetrics and Gynecology, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University of Torun, Ulica Ujejskiego 75, 85 168 Bydgoszcz, Poland
    Biomed Res Int 2014:616850. 2014
    Hypoxia-inducible factor-1α (HIF-1α), glucose transporter-1 (GLUT-1), and carbon anhydrase IX (CAIX) are important molecules that allow adaptation to hypoxic environments...
  10. pmc Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas
    N Burrows
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
    Endocr Relat Cancer 17:61-72. 2010
    ..Given the strong association of HIF-1 alpha with an aggressive disease phenotype and therapeutic resistance, this pathway may be an attractive target for improved therapy in thyroid carcinomas...
  11. doi Alternative splicing variants of carbonic anhydrase IX in human non-small cell lung cancer
    Francesca Malentacchi
    Clinical Biochemistry Unit, Department of Clinical Physiopathology, University of Florence, Viale Morgagni 6, I 50139 Florence, Italy
    Lung Cancer 64:271-6. 2009
    In human cancers, carbonic anhydrase IX (CAIX) contributes to maintain intracellular and extracellular pH under hypoxic conditions, but also influences regulation of cell proliferation and tumor progression...
  12. pmc Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas
    Arjen H G Cleven
    Departments of Pathology, GROW Research Institute, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Cell Oncol 29:229-40. 2007
    ..We studied the role of protein expression of hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, carbonic anhydrase 9 (CA9) and glucose transporter 1 (GLUT1) in patients with colorectal adenocarcinomas.
  13. ncbi Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts
    S Pastorekova
    Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Gastroenterology 112:398-408. 1997
    b>CA IX (formerly MN protein) is a carbonic anhydrase isoenzyme whose expression is associated with human tumors. However, it has also been found in normal gastric mucosa...
  14. ncbi Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250
    K Grabmaier
    Urological Research Laboratory, Department of Urology, University Hospital Nijmegen, Nijmegen, The Netherlands
    Int J Cancer 85:865-70. 2000
    ..the G250 antigen, which we identified as a transmembrane protein identical to the tumor-associated antigen MN/CAIX. We determined, by FISH analysis, that the G250/MN/CAIX gene is located on chromosome 9p12-13...
  15. doi Diagnostic implications of transcription factor Pax 2 protein and transmembrane enzyme complex carbonic anhydrase IX immunoreactivity in adult renal epithelial neoplasms
    Ruta Gupta
    Department of Pathology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Surg Pathol 33:241-7. 2009
    Pax 2, expressed by metanephric mesenchyme is vital for renal tubule formation and development. Carbonic anhydrase IX (CA IX) is implicated in cell proliferation, adhesion, and invasion...
  16. pmc Cyclooxygenase-2/carbonic anhydrase-IX up-regulation promotes invasive potential and hypoxia survival in colorectal cancer cells
    Pasquale Sansone
    Center for Applied Biomedical Research, St Orsola Malpighi University Hospital, University of Bologna, Bologna, Italy
    J Cell Mol Med 13:3876-87. 2009
    ..In conclusion, these data indicate that COX-2/CA-IX interplay promotes the aggressive behaviour of CRC cells...
  17. ncbi Immunohistochemistry of carbonic anhydrase isozyme IX (MN/CA IX) in human gut reveals polarized expression in the epithelial cells with the highest proliferative capacity
    J Saarnio
    Department of Surgery, University of Oulu, Oulu, Finland
    J Histochem Cytochem 46:497-504. 1998
    MN/CA IX is a recently discovered member of the carbonic anhydrase (CA) gene family that has been identified in the plasma membranes of certain tumor and epithelial cells and found to promote cell proliferation when transfected into ..
  18. ncbi Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer
    Stefan Kaluz
    Department of Microbiology and Molecular Genetics, College of Medicine, University of California at Irvine, California 92717, USA
    Cancer Res 63:917-22. 2003
    In the present study, we further studied mechanisms of transcriptional regulation of the tumor-associated carbonic anhydrase IX (CAIX). We identified PR5 in the CA9 promoter as another SP1/SP3-binding site...
  19. pmc Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome
    P N Span
    Department of Chemical Endocrinology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Br J Cancer 89:271-6. 2003
    Here, we set out to assess CA9 expression levels by real-time quantitative RT-PCR in breast cancer tissue samples obtained from 253 patients, and correlated those with relapse-free (RFS) survival...
  20. ncbi Redox state and carbonic anhydrase isozyme IX expression in human renal cell carcinoma: biochemical and morphological investigations
    Sergio A Tripodi
    Department of Pathology and Oncology, University of Siena, Siena, Italy
    J Enzyme Inhib Med Chem 19:287-91. 2004
    Clear renal cell carcinomas (RCC) frequently express carbonic anydrase IX (CA IX) because of non-functional mutation of von Hippel Lindau (VHL) tumor suppressor gene...
  21. ncbi Colocalization of carbonic anhydrase 9 expression and cell proliferation in human head and neck squamous cell carcinoma
    Ilse J Hoogsteen
    Department of Radiation Oncology, University Medical Center, St Radboud, Nijmegen, The Netherlands
    Clin Cancer Res 11:97-106. 2005
    ..The purpose of this study is to relate the expression of the hypoxia marker carbonic anhydrase 9 (CA9) to the uptake of iododeoxyuridine (IdUrd), a marker of proliferation, in head and neck squamous cell ..
  22. pmc The prognostic value of the hypoxia markers CA IX and GLUT 1 and the cytokines VEGF and IL 6 in head and neck squamous cell carcinoma treated by radiotherapy +/- chemotherapy
    Harlinde De Schutter
    Department of Radiation Oncology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    BMC Cancer 5:42. 2005
    ....
  23. ncbi Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer
    Seok Jin Kim
    Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Hospital, Durham, NC 27705, USA
    Lung Cancer 49:325-35. 2005
    ..compare the expression of two endogenous hypoxia markers, Hypoxia-inducible factor-1alpha (HIF-1alpha) and carbonic anhydrase IX (CA IX), with regard to their prognostic significance...
  24. doi Three-gene expression signature predicts survival in early-stage squamous cell carcinoma of the lung
    Marcin Skrzypski
    University of Gdansk, Gdansk, Poland
    Clin Cancer Res 14:4794-9. 2008
    ..Current staging methods are imprecise indications of prognosis, but high-risk patients can be identified by gene expression profiling and considered for adjuvant therapy...
  25. pmc The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths
    Pawel Swietach
    From the Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, Oxford OX1 3PT, United Kingdom
    J Biol Chem 284:20299-310. 2009
    We have studied the role of carbonic anhydrase 9 (CA9), a cancer-associated extracellular isoform of the enzyme carbonic anhydrase in multicellular spheroid growths (radius of approximately 300 microm) of human colon carcinoma HCT116 ..
  26. pmc Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX
    Vincenzo Alterio
    Istituto di Biostrutture e Bioimmagini CNR, Via Mezzocannone 16, 80134 Naples, Italy
    Proc Natl Acad Sci U S A 106:16233-8. 2009
    ..It is a marker of tumor hypoxia and a prognostic factor in several human cancers. An aberrant increase in CA IX expression in chronic hypoxia and during development of various carcinomas contributes to tumorigenesis through at ..
  27. doi Intact intracellular tail is critical for proper functioning of the tumor-associated, hypoxia-regulated carbonic anhydrase IX
    Alzbeta Hulikova
    Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovak Republic
    FEBS Lett 583:3563-8. 2009
    b>Carbonic anhydrase IX (CA IX) is a tumor-associated, hypoxia-induced enzyme involved in pH regulation and cell adhesion. Its catalytically active ectodomain (ECD) is linked to a transmembrane region and a short intracellular (IC) tail...
  28. doi Overexpression of carbonic anhydrase IX (CAIX) in vulvar cancer is associated with tumor progression and development of locoregional lymph node metastases
    Matthias Choschzick
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Virchows Arch 456:483-90. 2010
    b>Carbonic anhydrase IX (CAIX) is a strictly membranous expressed metalloenzyme involved in cell adhesion, pH homeostasis, and cancer progression. The protein is specifically overexpressed in a wide variety of malignant tumors...
  29. doi Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1alpha, GLUT1, and CAIX
    Chi long Chen
    Department of Pathology, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Virchows Arch 457:53-61. 2010
    ..hypoxia on the expression of hypoxia-inducible factor (HIF)-1alpha, glucose transporter 1 (GLUT1), and carbonic anhydrase IX (CAIX) was assessed in breast cancer cells derived from primary sites (HCC1395 and HCC1937) and metastatic ..
  30. pmc Carbonic anhydrase IX in tumor tissue and sera of patients with primary cervical cancer
    Linn Woelber
    Department of Gynecology and Gynecologic Oncology, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    BMC Cancer 11:12. 2011
    b>Carbonic anhydrase IX (CAIX) is a membranous expressed metalloenzyme involved in pH homeostasis and cell adhesion. The protein is overexpressed in a variety of tumors and potentially associated with negative outcome...
  31. pmc Recent developments in targeting carbonic anhydrase IX for cancer therapeutics
    Paul C McDonald
    Department of Integrative Oncology, British Columbia Cancer Research Centre and Cancer Agency, Vancouver, BC, Canada
    Oncotarget 3:84-97. 2012
    b>Carbonic anhydrase IX (CAIX) is a hypoxia-inducible enzyme that is overexpressed by cancer cells from many tumor types, and is a component of the pH regulatory system invoked by these cells to combat the deleterious effects of a high ..
  32. doi Carbonic anhydrase IX up-regulation is associated with adverse clinicopathologic and biologic factors in neuroblastomas
    Josiah V Dungwa
    Department of Histopathology, Bristol Royal Infirmary, BS2 8HW Bristol, UK
    Hum Pathol 43:1651-60. 2012
    The overexpression of carbonic anhydrase IX, a hypoxia-induced enzyme, is associated with an adverse prognosis in many cancers...
  33. doi Carbonic anhydrase IX: regulation and role in cancer
    Martin Benej
    Department of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia
    Subcell Biochem 75:199-219. 2014
    ..b>Carbonic anhydrase IX (CA IX) is the most widely expressed gene in response to hypoxia...
  34. ncbi A novel quasi-viral agent, MaTu, is a two-component system
    S Pastorekova
    Institute of Virology, Slovak Academy of Sciences, Bratislava
    Virology 187:620-6. 1992
    ..Both p54/58N peptides are glycosylated and they form oligomers linked by disulfidic bonds; p58X is not glycosylated and it does not form S-S-linked oligomers...
  35. ncbi Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment
    J Pastorek
    Institute of Virology, Slovak Academy of Sciences, Bratislava
    Oncogene 9:2877-88. 1994
    ..In addition, the analysis of biological consequences of MN expression of NIH3T3 cells provides the evidence in favour of MN protein involvement in control of cell proliferation and transformation...
  36. ncbi Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships
    R Opavsky
    Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Genomics 33:480-7. 1996
    ..So far, MN/CA IX is the only tumor-associated CA isoenzyme...
  37. ncbi Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumours
    A J Kivela
    Department of Anatomy and Cell Biology, University of Oulu, Finland
    Histochem Cell Biol 114:197-204. 2000
    ..This paper describes the localisation of CA IX and XII in the normal human pancreas and pancreatic tumours...
  38. ncbi Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy
    M I Koukourakis
    Tumour and Angiogenesis Research Group, Department of Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis 68100, Greece
    Clin Cancer Res 7:3399-403. 2001
    ..Recent studies show that carbonic anhydrase 9 (CA9) is up-regulated by hypoxia and that its immunohistochemical tissue distribution follows the ..
  39. ncbi Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase
    Stefan Kaluz
    Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Cancer Res 62:4469-77. 2002
    Transcription of the gene coding for the tumor-associated antigen MN/carbonic anhydrase IX (CAIX) is regulated by hypoxia-inducible factor 1 (HIF-1)...
  40. ncbi Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer
    Daniel E B Swinson
    Departments of Oncology, Pathology, and Epidemiology, University Hospitals of Leicester NHS Trust, United Kingdom
    J Clin Oncol 21:473-82. 2003
    ..To evaluate carbonic anhydrase (CA) IX as a surrogate marker of hypoxia and investigate the prognostic significance of different patterns of expression in non-small-cell lung cancer (NSCLC)...
  41. ncbi Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy
    Matthew H T Bui
    Department of Urology, University of California, Los Angeles, California 90095 1738, USA
    Clin Cancer Res 9:802-11. 2003
    ..To date, there are no molecular markers which can reliably predict RCC outcome. We investigated whether a novel kidney cancer marker, carbonic anhydrase IX (CAIX), is associated with progression and survival.
  42. pmc Expression of cell surface transmembrane carbonic anhydrase genes CA9 and CA12 in the human eye: overexpression of CA12 (CAXII) in glaucoma
    S Y Liao
    Department of Microbiology and Molecular Genetics, College of Medicine, University of California at Irvine, 92697 4025, USA
    J Med Genet 40:257-61. 2003
    ..In this work, we investigated the expression and tissue distribution of two recently discovered CA genes CA9 (CAIX) and CA12 (CAXII) in fetal, neonatal, and adult human eyes with and without glaucoma.
  43. pmc Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients
    J Zavada
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Flemingovo nam 2, 16637 Prague, Czech Republic
    Br J Cancer 89:1067-71. 2003
    Tumour-associated protein carbonic anhydrase IX (CA IX) has two major forms. One is a cell-associated, transmembrane protein seen on Western blots as a twin band of 54/58 kDa, expressed in gastric mucosa and in several types of cancer...
  44. ncbi Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin
    Eliska Svastova
    Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovak Republic
    Exp Cell Res 290:332-45. 2003
    b>Carbonic anhydrase IX (CA IX) is a cancer-associated transmembrane isoform of zinc metalloenzymes that catalyse interconversion between carbon dioxide and bicarbonate...
  45. pmc DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX
    Milota Kaluzova
    Department of Microbiology and Molecular Genetics, University of California at Irvine, College of Medicine, Irvine 92717, USA
    Mol Cell Biol 24:5757-66. 2004
    ..suppressor p53 and the hypoxia-inducible factor-1 (HIF-1)-dependent expression of the hypoxia marker, carbonic anhydrase IX (CAIX)...
  46. ncbi Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH
    Eliska Svastova
    Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovak Republic
    FEBS Lett 577:439-45. 2004
    ..The tumor-associated CA IX isoform is the best candidate, because its extracellular enzyme domain is highly active, expression is induced by ..
  47. ncbi Carbonic anhydrase IX in early-stage non-small cell lung cancer
    Seok Jin Kim
    Department of Medicine, Thoracic Oncology Program, Duke University Medical Center and Durham Veterans Affairs Hospital, Durham, North Carolina, USA
    Clin Cancer Res 10:7925-33. 2004
    ..Therefore, CA IX might allow tumors to acclimate to a hypoxic microenvironment, promoting tumor cell proliferation...
  48. ncbi Carbonic anhydrase IX (CA IX) mediates tumor cell interactions with microenvironment
    Zuzana Zavadova
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Flemingovo nam 2, 16637 Prague, Czech Republic
    Oncol Rep 13:977-82. 2005
    Expression of CA IX is normally restricted to the mucosa of alimentary tract, but on the other hand, it takes place in a high percentage of human cancers derived from tissues which are normally CA IX-negative...
  49. ncbi Carbonic anhydrase IX expression and tumor oxygenation status do not correlate at the microregional level in locally advanced cancers of the uterine cervix
    Arnulf Mayer
    Institute of Physiology and Pathophysiology, University of Mainz, Mainz, Germany
    Clin Cancer Res 11:7220-5. 2005
    b>Carbonic anhydrase IX (CA IX) can be induced by hypoxia in vitro and shows an immunohistochemical expression pattern that is predominantly found in perinecrotic tumor areas and correlates with exogenous markers of hypoxia, such as ..
  50. ncbi Tumor-associated carbonic anhydrases are linked to metastases in primary cervical cancer
    Joo Young Kim
    Research Institute, National Cancer Center, Gyeonggi, Goyang, Korea
    J Cancer Res Clin Oncol 132:302-8. 2006
    b>Carbonic anhydrase IX (CA9) has emerged as an important surrogate marker for hypoxia in solid tumors. CA12 shares a role with CA9 in acidification of micromilieu but it is less strictly regulated by hypoxia than CA9...
  51. ncbi Expression of carbonic anhydrase IX in astrocytic tumors predicts poor prognosis
    Joonas A Haapasalo
    Department of Pathology, Centre for Laboratory Medicine, Tampere University Hospital, FIN 33521 Tampere, Finland
    Clin Cancer Res 12:473-7. 2006
    b>Carbonic anhydrase IX (CA IX) is a hypoxia-inducible enzyme, which is associated with neoplastic growth. Ectopic CA IX expression has been observed in several tumors, whose normal counterparts do not express this enzyme...
  52. ncbi Role of carbonic anhydrase IX expression in prediction of the efficacy and outcome of primary epirubicin/tamoxifen therapy for breast cancer
    Daniele Generali
    Weatherall Molecular Oncology Laboratories, Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Endocr Relat Cancer 13:921-30. 2006
    The purpose of this study is to investigate the role of carbonic anhydrase IX (CAIX) expression in predicting the response to epirubicin and disease-free survival (DFS) in breast cancer patients enrolled in a single institution trial of ..
  53. ncbi Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia
    Robert Ihnatko
    Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, 845 05 Bratislava, Slovak Republic
    Int J Oncol 29:1025-33. 2006
    ..b>CA IX is pre-dominantly expressed in tumors with poor prognosis and its transcription and activity are induced by ..
  54. ncbi Expression of the hypoxia marker carbonic anhydrase 9 is associated with anaplastic phenotypes in meningiomas
    Heon Yoo
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    Clin Cancer Res 13:68-75. 2007
    ..of this study was to evaluate the prevalence of hypoxia in meningiomas using the endogenous hypoxia marker carbonic anhydrase 9 (CA9) and to relate the expression of CA9 to tumor vascularity, histopathologic grade, and clinical ..
  55. ncbi HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome
    Cynthia Trastour
    Institute of Signalling, Developmental Biology and Cancer Research, University of Nice, Nice, France
    Int J Cancer 120:1451-8. 2007
    ..The aim of our study was to evaluate the impact of HIF-1alpha and CA IX (carbonic anhydrase IX) (one of its target genes) expression on prognosis and treatment outcome of patients with breast cancer...
  56. ncbi CA9 gene expression in conventional renal cell carcinoma: a potential marker for prediction of early metastasis after nephrectomy
    Guorong Li
    Department of Urology, North Hospital, CHU of Saint Etienne, 42055, Saint Etienne Cedex 2, France
    Clin Exp Metastasis 24:149-55. 2007
    ..The present study aimed to test if analysis of the CA9 gene can provide useful information to predict early metastasis after nephrectomy...
  57. ncbi Effect of distributional heterogeneity on the analysis of tumor hypoxia based on carbonic anhydrase IX
    Vladimir V Iakovlev
    Ontario Cancer Institute, Princess Margaret Hospital, Toronto, ON, Canada
    Lab Invest 87:1206-17. 2007
    ..heterogeneity improves the correlation between histological measurements of the intrinsic hypoxia marker carbonic anhydrase IX (CAIX) and global tumor oxygenation status...
  58. pmc Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype
    M Barathova
    Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava 845 05, Slovak Republic
    Br J Cancer 98:129-36. 2008
    b>CA IX is a hypoxia-induced, cancer-associated carbonic anhydrase isoform with functional involvement in pH control and cell adhesion...
  59. pmc IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
    Pasquale Sansone
    Center for Applied Biomedical Research, St Orsola Malpighi University Hospital, Department of Pharmacology and Toxicology, University of Bologna, Bologna, Italy
    J Clin Invest 117:3988-4002. 2007
    ..Moreover, IL-6 induced Notch-3-dependent upregulation of the carbonic anhydrase IX gene and promoted a hypoxia-resistant/invasive phenotype in MCF-7 cells and MS...
  60. ncbi Cancer-associated carbonic anhydrases and their inhibition
    S Pastorekova
    Center of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovak Republic
    Curr Pharm Des 14:685-98. 2008
    ..Moreover, CA IX is a direct target of HIF and serves as a surrogate marker of hypoxia and prognostic indicator...
  61. doi Expression of carbonic anhydrase IX is associated with postoperative recurrence and poor prognosis in surgically treated oral squamous cell carcinoma
    Sung Weon Choi
    Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi 410 350, Korea
    Hum Pathol 39:1317-22. 2008
    b>Carbonic anhydrase IX (CA9) is reportedly overexpressed in several types of carcinomas, but little is known about the expression pattern of CA9 in oral cavity cancer and the corresponding normal tissues...
  62. pmc Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma
    Jean Jacques Patard
    CNRS UMR6061 Genetics and development, IFR 140, University of Rennes 1, Rennes, France
    Int J Cancer 123:395-400. 2008
    We attempted to describe, in a series of clear cell renal cell carcinoma (RCC), the relationship between CAIX expression, VHL gene mutations, tumor characteristics and outcome. Radical nephrectomy was performed in 100 patients...
  63. ncbi Prognostic value of the co-expression of carbonic anhydrase IX and vascular endothelial growth factor in patients with clear cell renal cell carcinoma
    Nguyen Ba Phuoc
    Department of Urology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Oncol Rep 20:525-30. 2008
    This study aimed to investigate whether the expression of carbonic anhydrase IX (CAIX) is associated with the expression of vascular endothelial growth factor (VEGF) and whether the co-expression of the two correlates with survival ..
  64. doi Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes
    Mika Hilvo
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, FI 33014 Tampere, Finland
    J Biol Chem 283:27799-809. 2008
    b>Carbonic anhydrase IX (CA IX) is an exceptional member of the CA protein family; in addition to its classical role in pH regulation, it has also been proposed to participate in cell proliferation, cell adhesion, and tumorigenic processes...
  65. pmc The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy
    E Y Tan
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK
    Br J Cancer 100:405-11. 2009
    ..001) in a multivariate analysis. Carbonic anhydrase IX expression was positively correlated with tumour size (P=0.005), tumour grade (P<0...
  66. ncbi Soluble form of carbonic anhydrase IX (CAIX) in transitional cell carcinoma of urinary tract
    L Hyrsl
    Department of Urology, Charles University 2nd Faculty of Medicine and Hospital Motol, Prague, Czech, Republic
    Neoplasma 56:298-302. 2009
    We investigated the expression of cell-associated CAIX protein in histological sections of the transitional cell carcinoma (TCC) of the urinary tract and of the soluble form of CAIX (s-CAIX) shed by the tumor into the serum and urine of ..
  67. doi Investigation of hypoxia and carbonic anhydrase IX expression in a renal cell carcinoma xenograft model with oxygen tension measurements and ¹²⁴I-cG250 PET/CT
    Nathan Lawrentschuk
    University of Melbourne Department of Surgery, Austin Hospital, Melbourne, Victoria, Australia
    Urol Oncol 29:411-20. 2011
    ..b>Carbonic anhydrase IX (CA IX) is a protein stimulated by hypoxia and involved in angiogenesis, and is a potential tumor target ..
  68. doi CA9 gene: single nucleotide polymorphism predicts metastatic renal cell carcinoma prognosis
    Michela de Martino
    Department of Urology, University of California Los Angeles, Los Angeles, California 90095 1738, USA
    J Urol 182:728-34. 2009
    We assessed CA9 single nucleotide polymorphisms and mutations, and their association with CAIX protein expression, overall survival and response to interleukin-2 in white patients with metastatic clear cell renal cell carcinoma.
  69. pmc Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology
    Chen Xu
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e9625. 2010
    b>Carbonic anhydrase IX (CAIX, gene G250/MN-encoded transmembrane protein) is highly expressed in various human epithelial tumors such as renal clear cell carcinoma (RCC), but absent from the corresponding normal tissues...
  70. pmc The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis
    Kristiina Nordfors
    Department of Pathology, Tampere University Hospital, Tampere, Finland
    BMC Cancer 10:148. 2010
    ....
  71. pmc High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer
    M Ilie
    Laboratory of Clinical and Experimental Pathology, Louis Pasteur Hospital, Nice, France
    Br J Cancer 102:1627-35. 2010
    b>Carbonic anhydrase IX (CAIX) is an enzyme upregulated by hypoxia during tumour development and progression...
  72. ncbi The expressions of carbonic anhydrase 9 and vascular endothelial growth factor in astrocytic tumors predict a poor prognosis
    Heon Yoo
    Neuro Oncology Clinic, Center for Specific Organs Cancer, Goyang, Republic of Korea
    Int J Mol Med 26:3-9. 2010
    ..The objectives of this study were to evaluate the expressions of carbonic anhydrase 9 (CA9) and vascular endothelial growth factor (VEGF) in astrocytic gliomas and to relate patterns of ..
  73. pmc Carbonic anhydrase IX expression in renal neoplasms: correlation with tumor type and grade
    Elizabeth M Genega
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Clin Pathol 134:873-9. 2010
    b>Carbonic anhydrase IX (CAIX), a hypoxia-induced protein, is expressed in some renal tumors...
  74. pmc A new peptide ligand for targeting human carbonic anhydrase IX, identified through the phage display technology
    Vasileios Askoxylakis
    Department of Radiooncology and Radiation Therapy, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 5:e15962. 2010
    b>Carbonic anhydrase IX (CAIX) is a transmembrane enzyme found to be overexpressed in various tumors and associated with tumor hypoxia...
  75. doi Carbonic anhydrase IX (CA9) modulates tumor-associated cell migration and invasion
    Hye Jin Shin
    Research Institute and Hospital, National Cancer Center, Goyang 410 769, Korea
    J Cell Sci 124:1077-87. 2011
    Expression of carbonic anhydrase IX (CA9) was shown to be strongly involved in high incidences of metastasis and poor prognosis in various human tumors...
  76. pmc Catalysis and pH control by membrane-associated carbonic anhydrase IX in MDA-MB-231 breast cancer cells
    Ying Li
    Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 286:15789-96. 2011
    b>Carbonic anhydrase IX (CAIX) is a membrane-bound, tumor-related enzyme whose expression is often considered a marker for hypoxia, an indicator of poor prognosis in the majority of cancer patients, and is associated with acidification of ..
  77. doi Overexpression of carbonic anhydrase IX (CAIX) is an independent unfavorable prognostic marker in endometrioid ovarian cancer
    Matthias Choschzick
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Virchows Arch 459:193-200. 2011
    b>Carbonic anhydrase IX (CAIX) is a strictly membranous expressed metalloenzyme involved in cell adhesion, pH homeostasis, and cancer progression. This study was designed to assess the role of CAIX in primary ovarian cancer...
  78. pmc Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer
    Volkmar Muller
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20241 Hamburg, Germany
    Breast Cancer Res 13:R71. 2011
    ..b>Carbonic anhydrase IX (CAIX) is a metalloenzyme involved in cell adhesion, growth and survival of tumor cells...
  79. doi Phosphorylation of carbonic anhydrase IX controls its ability to mediate extracellular acidification in hypoxic tumors
    Peter Ditte
    Department of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Cancer Res 71:7558-67. 2011
    In the hypoxic regions of a tumor, carbonic anhydrase IX (CA IX) is an important transmembrane component of the pH regulatory machinery that participates in bicarbonate transport...
  80. pmc Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain
    Eliska Svastova
    Department of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, 845 05 Bratislava, Slovak Republic
    J Biol Chem 287:3392-402. 2012
    b>Carbonic anhydrase IX (CA IX) is a hypoxia-induced cell surface enzyme expressed in solid tumors, and functionally involved in acidification of extracellular pH and destabilization of intercellular contacts...
  81. doi High stromal carbonic anhydrase IX expression is associated with nodal metastasis and decreased survival in patients with surgically-treated oral cavity squamous cell carcinoma
    Nigel T Brockton
    Division of Preventive Oncology, Department of Oncology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Oral Oncol 48:615-22. 2012
    ..b>Carbonic anhydrase IX (CAIX) is a marker of tissue hypoxia and we have recently shown that stromal CAIX is associated with ..
  82. pmc Prognostic utility of pre-operative circulating osteopontin, carbonic anhydrase IX and CRP in renal cell carcinoma
    S H Sim
    St James s Institute of Oncology, Bexley Wing, St James s University Hospital, Leeds, UK
    Br J Cancer 107:1131-7. 2012
    ..Objectively measured circulating biomarkers of prognosis complementing existing clinicopathological models are needed in renal cell carcinoma (RCC)...
  83. pmc Carbonic anhydrase IX as a potential biomarker of efficacy in metastatic clear-cell renal cell carcinoma patients receiving sorafenib or placebo: analysis from the treatment approaches in renal cancer global evaluation trial (TARGET)
    Toni K Choueiri
    Kidney Cancer Program, Dana Farber Harvard Cancer Center, Boston, MA 02215, USA Dana Farber Cancer Institute, Boston, MA 02215, USA Brigham and Women s Hospital, Boston, MA 02215, USA
    Urol Oncol 31:1788-93. 2013
    Retrospective data analyses have suggested that carbonic anhydrase IX (CAIX) may have a predictive role in patients with metastatic clear cell renal cell carcinoma (ccRCC) receiving high dose interleukin-2 or sorafenib...
  84. doi Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche
    F E Lock
    Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, British Columbia, Canada
    Oncogene 32:5210-9. 2013
    ..Tumor hypoxia plays a key role in regulating EMT and cancer stem cell function. Carbonic anhydrase IX (CAIX) is a hypoxia-inducible protein that regulates cellular pH to promote cancer cell survival and ..
  85. pmc Impacts of CA9 gene polymorphisms and environmental factors on oral-cancer susceptibility and clinicopathologic characteristics in Taiwan
    Ming Hsien Chien
    Wan Fan Hospital, Taipei Medical University, Taipei, Taiwan
    PLoS ONE 7:e51051. 2012
    In Taiwan, oral cancer has causally been associated with environmental carcinogens. Carbonic anhydrase 9 (CA9) is reportedly overexpressed in several types of carcinomas and is generally considered a marker of malignancy...
  86. pmc Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells
    Tania Fiaschi
    Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Tuscany, Italy
    Cell Cycle 12:1791-801. 2013
    ..cancer-associated fibroblasts, upon their activation by cancer delivered soluble factors, rapidly express carbonic anhydrase IX (CA IX)...
  87. doi Carbon anhydrase IX specific immune responses in patients with metastatic renal cell carcinoma potentially cured by interleukin-2 based immunotherapy
    Susanne Rasmussen
    Department of International Health, Immunology and Microbiology, The Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    Immunopharmacol Immunotoxicol 35:487-96. 2013
    ..cell carcinomas (ccRCC) show high and homogeneous expression levels of the tumor associated antigen (TAA) carbonic anhydrase IX (CAIX), and treatment with interleukin-2 (IL-2) based immunotherapy can lead to cure in patients with ..
  88. doi Response of CAIX and CAXII to in vitro re-oxygenation and clinical significance of the combined expression in NSCLC patients
    Marius Ilie
    Centre Hospitalier Universitaire de Nice, Louis Pasteur Hospital, Laboratory of Clinical and Experimental Pathology, Nice, France Institute of Research on Cancer and Ageing in Nice IRCAN, INSERM U1081 CNRS UMR 7284, Team 3, Nice, France University of Nice Sophia Antipolis, Faculty of Medicine, Nice, France
    Lung Cancer 82:16-23. 2013
    ..Although hypoxic regulation of the expression of the carbonic anhydrases CAIX and CAXII is well established, the effect of re-oxygenation on these proteins remains to be elucidated...
  89. doi Immunohistochemical reevaluation of carbonic anhydrase IX (CA IX) expression in tumors and normal tissues
    Adelina Luong-Player
    Dept of Laboratory Medicine, MC 01 31, Geisinger Medical Center, 100 N Academy Ave, Danville, PA 17822
    Am J Clin Pathol 141:219-25. 2014
    To immunohistochemically evaluate the carbonic anhydrase IX (CA IX) expression on 1,551 cases of tumors and normal tissues from various organs.
  90. doi Expression pattern of carbonic anhydrase IX in Medullary thyroid carcinoma supports a role for RET-mediated activation of the HIF pathway
    Martina Takacova
    Department of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia Center for Molecular Medicine, Slovak Academy of Sciences, Bratislava, Slovakia
    Am J Pathol 184:953-65. 2014
    ..Although CAXII was present in all types of thyroid carcinomas, CAIX, a direct HIF target implicated in tumor progression, was associated with aggressive medullary and anaplastic ..
  91. ncbi The catalytic properties of human carbonic anhydrase IX
    T Wingo
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610 0267, USA
    Biochem Biophys Res Commun 288:666-9. 2001
    Human carbonic anhydrase IX (CA IX) is an integral membrane protein and a member of the alpha class of carbonic anhydrases that includes the human and animal enzymes...
  92. ncbi Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas
    David Hedley
    Division of Experimental Therapeutics and Department of Radiation Oncology, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
    Clin Cancer Res 9:5666-74. 2003
    ..Recent studies suggest that carbonic anhydrase IX (CA IX), which is regulated via hypoxia-inducible factor 1, is a useful intrinsic marker of tumor hypoxia.
  93. pmc Carbonic anhydrase IX in oligodendroglial brain tumors
    Sally Jarvela
    Department of Pathology, Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
    BMC Cancer 8:1. 2008
    b>Carbonic anhydrase IX is a hypoxia-induced enzyme that has many biologically important functions, including its role in cell adhesion and invasion.
  94. pmc Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast
    C C Wykoff
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    Am J Pathol 158:1011-9. 2001
    ..b>CA IX expression was rare in normal epithelium and benign lesions, but was present focally in DCIS (50% of cases) and in ..
  95. pmc Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer
    S Ivanov
    Science Applications International Corporation, Laboratory of Immunobiology, Bldg 560, NCI FCRDC, P O Box B, Frederick, MD 21702, USA
    Am J Pathol 158:905-19. 2001
    ..Expression was also analyzed in cultured cells under hypoxic conditions. Expression of CA IX and CA XII in normal adult tissues was detected only in highly specialized cells and for most tissues their ..
  96. ncbi The role of carbonic anhydrases in renal physiology
    J M Purkerson
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York, USA
    Kidney Int 71:103-15. 2007
    ..CAII and CAIV predominate in human and rabbit kidneys; in rodent kidneys, CAXII, and CAXIV are also present. CAIX is expressed by renal cell carcinoma (RCC)...
  97. pmc Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer
    C P S Potter
    Cancer Research UKGrowth Factor Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Br J Cancer 89:2-7. 2003
    ..The tumour-associated isoenzymes, CAIX and CAXII, are expressed in a wide variety of malignancies and appear to be tightly regulated by microenvironmental ..
  98. pmc Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma
    P H Watson
    Department of Pathology, University of Manitoba, Winnipeg, Canada
    Br J Cancer 88:1065-70. 2003
    ..Furthermore, we identified CA IX to be a poor prognostic factor in breast cancer...
  99. doi Clear cell meningioma: a clinicopathologic study of 18 tumors and examination of the use of CD10, CA9, and RCC antibodies to distinguish between clear cell meningioma and metastatic clear cell renal cell carcinoma
    Richard A Prayson
    Department of Anatomic Pathology and Brain Tumor Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Appl Immunohistochem Mol Morphol 18:422-8. 2010
    ..The purpose of this study is to evaluate the use of immunomarkers CA9, CD10, and RCC in differentiating between CCM and clear cell renal cell carcinoma...
  100. ncbi [The relationship of clinical manifestations and age distribution in enterovirus infections--viral isolation and seroepidemiology in Aichi Prefecture]
    K Sakae
    Department of Public Health, Yokohama City University School of Medicine
    Kansenshogaku Zasshi 66:1670-81. 1992
    ..patients (Ex) and a seroepidemiological study of echovirus type 7 (E7), E9, E18 and group A coxsackievirus type 9 (CA9), was performed...
  101. doi Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia
    Peter Schraml
    Department of Pathology, Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    Mod Pathol 22:31-6. 2009
    ..by DNA sequencing and by immunohistochemical staining for the hypoxia-inducible factor-alpha target gene products CA9 and GLUT-1...

Research Grants9

  1. Susan Cooke Frost; Fiscal Year: 2016
    ..Increased carbonic anhydrase IX (CAIX) expression in primary breast cancers is a marker for hypoxia, an indicator of poor prognosis, and ..
  2. 124I-cG250 ImmunoPET Imaging of Sunitinib Treatment Response in Renal Cell Cancer
    STEVEN MARK LARSON; Fiscal Year: 2012
    ..Our core hypothesis is that at baseline, detection of CAIX antigen expression in clear cell renal cancer, based on 124I- cG250 ImmunoPET, will provide improved single test ..
  3. Eugene D Kwon; Fiscal Year: 2014
    ..as well as with other molecular markers that assist in fostering tumor cell proliferation and survival (IMP3, CAIX, Ki-67, and survivin) to improve outcome prediction for ccRCC patients. Specific Aim 2...
  4. Huan Xie; Fiscal Year: 2015
    ..studies that successfully prepared and characterized a novel nanoconstruct composed of GNR and anti-carbonic anhydrase IX (CAIX) antibody, which is a viable biomarker for tumor hypoxia...
  5. The Role of Nutrition in Virus-Induced Optic Neuropathy
    Melinda Beck; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Coxsackievirus A9 (CA9) and a variant, impaired in replication but persistently present in CSF over several months, were isolated from patients' CSF specimens during an epidemic of ..
  6. Single Cell Analysis of Cross Talk Among Kinase Pathways
    Stefan Kaluz; Fiscal Year: 2008
    ..These studies will provide additional information relating to our understanding of the consequencesof activationof kinase signaling pathwayswith respect to malignant transformation, aggressive tumor growth and survival. ..
  7. QUANTITATION OF HYPOXIC TUMOR CELLS
    Peggy Olive; Fiscal Year: 2001
    ..To validate the models, expression of GFP will be analyzed in relation to proliferation, hypoxia marker binding, and clonogenicity following irradiation. ..
  8. Phase II Study of 44Gy from 131I-81C6 for CNS Tumors
    David Reardon; Fiscal Year: 2004
    ..To further define the toxicity of this approach and Specific Aim 3.To determine the impact of this therapy on quality of life. ..
  9. Role of Cystatins in Oral Cancer Metastasis
    Nadarajah Vigneswaran; Fiscal Year: 2007
    ..Insights gained from these studies will be used to design therapeutic strategies for restoring immune competence of OSCC patients to prevent and eradicate OSCC metastasis. [unreadable] [unreadable] [unreadable]..