c-Myc

Summary

Gene Symbol: c-Myc
Description: MYC proto-oncogene, bHLH transcription factor
Alias: MRTL, MYCC, bHLHe39, c-Myc, myc proto-oncogene protein, avian myelocytomatosis viral oncogene homolog, class E basic helix-loop-helix protein 39, myc-related translation/localization regulatory factor, proto-oncogene c-Myc, transcription factor p64, v-myc avian myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene homolog
Species: human

Top Publications

  1. ncbi c-Myc-regulated microRNAs modulate E2F1 expression
    Kathryn A O'Donnell
    Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 435:839-43. 2005
  2. pmc Targeting MYC dependence in cancer by inhibiting BET bromodomains
    Jennifer A Mertz
    Constellation Pharmaceuticals, Inc, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 108:16669-74. 2011
  3. ncbi Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone
    Tina Marie Green
    Department of Pathology, Odense University Hospital, J B Winsløws Vej 15, DK 5000 Odense C, Denmark
    J Clin Oncol 30:3460-7. 2012
  4. ncbi CIP2A inhibits PP2A in human malignancies
    Melissa R Junttila
    Centre for Biotechnology, University of Turku and Abo Akademi University, 20520 Turku, Finland
    Cell 130:51-62. 2007
  5. pmc Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone
    Nathalie A Johnson
    British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    J Clin Oncol 30:3452-9. 2012
  6. pmc NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
    Teresa Palomero
    Institute for Cancer Genetics and Joint Centers for Systems Biology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:18261-6. 2006
  7. pmc HIF-1alpha induces cell cycle arrest by functionally counteracting Myc
    Minori Koshiji
    Laboratory of Human Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 23:1949-56. 2004
  8. pmc Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
    Jung whan Kim
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Biol 27:7381-93. 2007
  9. pmc Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis
    Bora Gurel
    Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
    Mod Pathol 21:1156-67. 2008
  10. ncbi The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins
    S B McMahon
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    Cell 94:363-74. 1998

Research Grants

  1. NF-kappaB N-myc in Oncogenic Pathways of the CNS
    Raquel Sitcheran; Fiscal Year: 2010
  2. Structure-based design of novel low molecular weight c-Myc inhibitors
    EDWARD VICTOR PROCHOWNIK; Fiscal Year: 2013
  3. Investigation of Myc Oncoprotein in B lymphocyte Development and Transformation
    Brian M Iritani; Fiscal Year: 2012
  4. Andrei Goga; Fiscal Year: 2014
  5. Interplay of Myc, Tumor Supressors and Regulators of Differentiation in Lymphoma
    John L Cleveland; Fiscal Year: 2012
  6. Chi V Dang; Fiscal Year: 2016
  7. Analysis of the Human c-myc Gene Replication Origin
    Michael Leffak; Fiscal Year: 2012
  8. Investigation of a novel regulator of Myc-driven tumorigenesis
    Mark W Gramling; Fiscal Year: 2012
  9. Functional analysis of transcriptional program regulated by the c-MYC oncoprotein
    Steven B McMahon; Fiscal Year: 2012
  10. ROBERT NEIL EISENMAN; Fiscal Year: 2016

Detail Information

Publications439 found, 100 shown here

  1. ncbi c-Myc-regulated microRNAs modulate E2F1 expression
    Kathryn A O'Donnell
    Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 435:839-43. 2005
    ....
  2. pmc Targeting MYC dependence in cancer by inhibiting BET bromodomains
    Jennifer A Mertz
    Constellation Pharmaceuticals, Inc, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 108:16669-74. 2011
    ..These findings demonstrate that pharmacologic inhibition of MYC is achievable through targeting BET bromodomains. Such inhibitors may have clinical utility given the widespread pathogenetic role of MYC in cancer...
  3. ncbi Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone
    Tina Marie Green
    Department of Pathology, Odense University Hospital, J B Winsløws Vej 15, DK 5000 Odense C, Denmark
    J Clin Oncol 30:3460-7. 2012
    ..DHLs are characterized by poor outcome. We tested whether DLBCLs with high expression of MYC protein and BCL2 protein share the clinical features and poor prognosis of DHLs...
  4. ncbi CIP2A inhibits PP2A in human malignancies
    Melissa R Junttila
    Centre for Biotechnology, University of Turku and Abo Akademi University, 20520 Turku, Finland
    Cell 130:51-62. 2007
    ..Thus, our data show that CIP2A is a human oncoprotein that inhibits PP2A and stabilizes c-Myc in human malignancies...
  5. pmc Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone
    Nathalie A Johnson
    British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    J Clin Oncol 30:3452-9. 2012
    ..We investigated whether expression of MYC protein, with or without BCL2 protein expression, could risk-stratify patients at diagnosis...
  6. pmc NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
    Teresa Palomero
    Institute for Cancer Genetics and Joint Centers for Systems Biology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:18261-6. 2006
    ..These results identify c-MYC as an essential mediator of NOTCH1 signaling and integrate NOTCH1 activation with oncogenic signaling pathways upstream of c-MYC...
  7. pmc HIF-1alpha induces cell cycle arrest by functionally counteracting Myc
    Minori Koshiji
    Laboratory of Human Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 23:1949-56. 2004
    ..Hence, we propose that Myc is an integral part of a novel HIF-1alpha pathway, which regulates a distinct group of Myc target genes in response to hypoxia...
  8. pmc Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
    Jung whan Kim
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Biol 27:7381-93. 2007
    ....
  9. pmc Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis
    Bora Gurel
    Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
    Mod Pathol 21:1156-67. 2008
    ....
  10. ncbi The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins
    S B McMahon
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    Cell 94:363-74. 1998
    ..These data suggest that TRRAP is an essential cofactor for both the c-Myc and E1A/E2F oncogenic transcription factor pathways...
  11. pmc SOX2 has a crucial role in the lineage determination and proliferation of mesenchymal stem cells through Dickkopf-1 and c-MYC
    S B Park
    Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea
    Cell Death Differ 19:534-45. 2012
    ..Therefore, these results suggest that SOX2 might have a specific function by regulating DKK1 and c-MYC in the differentiation and growth of ASCs, which is separate from its roles in ESCs...
  12. pmc Widespread microRNA repression by Myc contributes to tumorigenesis
    Tsung Cheng Chang
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 40:43-50. 2008
    ..We further show that enforced expression of repressed miRNAs diminishes the tumorigenic potential of lymphoma cells. These results demonstrate that extensive reprogramming of the miRNA transcriptome by Myc contributes to tumorigenesis...
  13. pmc Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells
    Sudha Mannava
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cell Cycle 7:2392-400. 2008
    ..Our data establish a novel functional link between C-MYC and dNTP metabolism and identify its role in proliferation of tumor cells...
  14. pmc The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
    Antje Menssen
    Experimental and Molecular Pathology, Institute of Pathology, Ludwig Maximilians University Munich, D 80337 Munich, Germany
    Proc Natl Acad Sci U S A 109:E187-96. 2012
    ..Constitutive activation of this positive feedback loop may contribute to the development and maintenance of tumors in the context of deregulated c-MYC...
  15. ncbi Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter
    Siqin Wu
    Upsala Genetic Center, Department of Plant Biology, Swedish University of Agricultural Sciences
    Oncogene 22:351-60. 2003
    ..In conclusion, repression of differentiation-induced p21 expression through Miz-1 may be an important mechanism by which Myc blocks differentiation...
  16. doi Expression pattern of Oct-4, Sox2, and c-Myc in the primary culture of human dental pulp derived cells
    Lu Liu
    Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Sun Yat Sen University, Guangzhou, Guangdong, China
    J Endod 37:466-72. 2011
    ....
  17. pmc B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia
    Weizhou Zhang
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:18956-60. 2010
    ....
  18. ncbi c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription
    Azadeh Arabi
    Södertörns högskola, S 141 89 Huddinge, Sweden
    Nat Cell Biol 7:303-10. 2005
    ..These results suggest that c-Myc coordinates the activity of all three nuclear RNA polymerases, and thereby plays a key role in regulating ribosome biogenesis and cell growth...
  19. pmc Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia
    Letetia Jones
    Helen Diller Family Comprehensive Cancer Center and Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 207:2581-94. 2010
    ..In addition, we found that human myeloid leukemias with trisomy 8 have increased MYC. These data show that gain of MYC can contribute to the pathogenic effect of the most common trisomy of human AML...
  20. pmc Estrogen induces c-myc gene expression via an upstream enhancer activated by the estrogen receptor and the AP-1 transcription factor
    Chunyu Wang
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Endocrinol 25:1527-38. 2011
    ..These results solve the long-standing question in the field of endocrinology of how estrogen induces c-myc expression...
  21. pmc MYC protein inhibits transcription of the microRNA cluster MC-let-7a-1~let-7d via noncanonical E-box
    Zifeng Wang
    Laboratory of Integrated Biosciences, School of Life Sciences, Sun Yat Sen University, Guangzhou, China
    J Biol Chem 286:39703-14. 2011
    ....
  22. pmc Characterization of the colorectal cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583
    Sari Tuupanen
    Department of Medical Genetics, Genome Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Cancer Genet 205:25-33. 2012
    ....
  23. pmc RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells
    Andre O Von Bueren
    Neuro Oncology Program, University Children s Hospital, Zurich, Switzerland
    BMC Cancer 9:10. 2009
    ..Deregulation of c-MYC is evident in numerous human cancers. In MB, over-expression of c-MYC has been shown to cause anaplasia and correlate with unfavorable prognosis...
  24. pmc AP4 encodes a c-MYC-inducible repressor of p21
    Peter Jung
    Molecular Tumorpathology, Institute of Pathology, Ruhr University Bochum, D 44789 Bochum, Germany
    Proc Natl Acad Sci U S A 105:15046-51. 2008
    ..Notably, AP4 is specifically expressed in colonic progenitor and colorectal carcinoma cells. In conclusion, our results indicate that c-MYC employs AP4 to maintain cells in a proliferative, progenitor-like state...
  25. pmc The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis
    Barbara Herkert
    Theodor Boveri Institute and 2 Rudolf Virchow Center, University of Wurzburg, D 97070 Wurzburg, Germany
    J Cell Biol 188:905-18. 2010
    ..Our data point to a tumor-suppressive pathway that weakens cell-cell and cell-matrix interactions in response to expression of Arf and that may thereby facilitate the elimination of cells harboring an oncogenic mutation...
  26. ncbi c-MYC: more than just a matter of life and death
    Stella Pelengaris
    Molecular Medicine Research Centre, University of Warwick, Coventry CV4 7AL, UK
    Nat Rev Cancer 2:764-76. 2002
    ..Regulatable transgenic mouse models of oncogenesis have shed light on these issues and provide hope for effective cancer therapies...
  27. ncbi The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells
    Letizia Carramusa
    Dipartimento di Oncologia Sperimentale e Applicazioni Cliniche, Universita di Palermo, Palermo, Italy
    J Cell Physiol 213:511-8. 2007
    ..The results of transfection experiments in RAT1-MycER cells and chromatin immunoprecipitation (ChIP) assays in proliferating and differentiated neuroblastoma cells indicate that PVT-1 is a downstream target of Myc proteins...
  28. ncbi MYC insertions in diffuse-type gastric adenocarcinoma
    Danielle Queiroz Calcagno
    Human Cytogenetics Laboratory, Institute of Biological Sciences, Federal University of Para, Belem, Para, Brazil
    Anticancer Res 29:2479-83. 2009
    ..MYC is important in gastric carcinogenesis. A few studies reported MYC translocation or insertion associated with gastric cancer...
  29. pmc The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression
    Juhong Liu
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892 1500, USA
    EMBO J 25:2119-30. 2006
    ..Engineering FUSE into episomal vectors predictably re-programmed metallothionein-promoter-driven reporter expression. The in vitro recruitment of FBP and FIR to dynamically stressed c-myc DNA paralleled the in vivo process...
  30. ncbi The ubiquitin-specific protease USP28 is required for MYC stability
    Nikita Popov
    Institute of Molecular Biology and Tumor Research, Emil Mannkopff Str 2, 35033 Marburg, Germany
    Nat Cell Biol 9:765-74. 2007
    ..High expression levels of USP28 are found in colon and breast carcinomas, and stabilization of MYC by USP28 is essential for tumour-cell proliferation...
  31. pmc A core MYC gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response
    Sanjay Chandriani
    Department of Molecular Biology, Princeton University, Princeton, NJ, USA
    PLoS ONE 4:e6693. 2009
    ..The MYC oncogene contributes to induction and growth of many cancers but the full spectrum of the MYC transcriptional response remains unclear...
  32. pmc 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC
    Nasim Ahmadiyeh
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston MA 02115, USA
    Proc Natl Acad Sci U S A 107:9742-6. 2010
    ..We therefore propose that the 8q24 risk loci operate through a common mechanism-as tissue-specific enhancers of MYC...
  33. ncbi MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc
    K Mori
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo 060, Japan
    J Biol Chem 273:29794-800. 1998
    ..Furthermore, MM-1 repressed the activation of E-box-dependent transcription by c-Myc...
  34. ncbi A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth
    Michael Wanzel
    Institute for Molecular Biology and Tumor Research IMT, Emil Mannkopff Str 2, 35033 Marburg, Germany
    Nat Cell Biol 10:1051-61. 2008
    ..As L23 is encoded by a direct target gene of Myc, this regulatory circuit may provide a feedback mechanism that links translation of Myc target genes and cell growth to Miz1-dependent cell-cycle arrest...
  35. ncbi Six lysine residues on c-Myc are direct substrates for acetylation by p300
    Kangling Zhang
    Department of Chemistry, University of California at Riverside, Riverside, CA 92521, USA
    Biochem Biophys Res Commun 336:274-80. 2005
    ..Our results further indicate that p300 can acetylate DNA-bound Myc:Max complexes and that acetylated Myc:Max heterodimers efficiently interact with Miz-1...
  36. pmc New model systems provide insights into Myc-induced transformation
    A R Wasylishen
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Oncogene 30:3727-34. 2011
    ....
  37. pmc Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress
    Kishore B Challagundla
    Department of Molecular and Medical Genetics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Mol Cell Biol 31:4007-21. 2011
    ..Together, our results identify a novel regulatory paradigm wherein L11 plays a critical role in controlling c-myc mRNA turnover via recruiting miRISC in response to ribosomal stress...
  38. pmc c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells
    Justine E Roderick
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA
    Blood 123:1040-50. 2014
    ..These findings demonstrate a critical role for c-Myc in LIC maintenance and provide evidence that MYC inhibition may be an effective therapy for relapsed/IF T-ALL patients. ..
  39. doi Expressions of p53, c-MYC, BCL-2 and apoptotic index in human osteosarcoma and their correlations with prognosis of patients
    Xing Wu
    Department of Orthopaedics, Shanghai Tenth People s Hospital, Tongji University School of Medicine, China
    Cancer Epidemiol 36:212-6. 2012
    ....
  40. pmc The guanine-quadruplex structure in the human c-myc gene's promoter is converted into B-DNA form by the human poly(ADP-ribose)polymerase-1
    Anna Fekete
    Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary
    PLoS ONE 7:e42690. 2012
    ..PARP-1 might be a new member of the group of proteins participating in the regulation of transcription through their interactions with GQ structures present in the promoters of different genes...
  41. pmc Secondary genomic rearrangements involving immunoglobulin or MYC loci show similar prevalences in hyperdiploid and nonhyperdiploid myeloma tumors
    Ana Gabrea
    Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    Genes Chromosomes Cancer 47:573-90. 2008
    ..We conclude that IG light chain and MYC rearrangements, as well as secondary IGH rearrangements, make similar contributions to the progression of both HRD and NHRD MM tumors...
  42. doi HepaCAM induces G1 phase arrest and promotes c-Myc degradation in human renal cell carcinoma
    Qiao Lin Zhang
    Department of Laboratory Diagnosis, Chongqing Medical University, Chongqing 400016, China
    J Cell Biochem 112:2910-9. 2011
    ..Thus, our research implies that the decrease in c-Myc protein expression, resulting from ectopic expression of hepaCAM, may contribute to the inhibition of proliferation in these cells...
  43. ncbi A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas
    S R Hann
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Cell 52:185-95. 1988
    ..In Burkitt's lymphomas, the removal or specific mutation of exon 1 in c-myc translocations correlates with suppression of synthesis of the larger protein, and thus may contribute to the oncogenic activation of c-myc...
  44. pmc Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway
    Malte Buchholz
    Translational Genome Research Group, Department of Internal Medicine I, University of Ulm, Ulm, Germany
    EMBO J 25:3714-24. 2006
    ..Together, these results demonstrate that ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway is an important mechanism of oncogenic c-myc activation in pancreatic cancer...
  45. pmc Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
    Mariia Yuneva
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    J Cell Biol 178:93-105. 2007
    ....
  46. doi Interrelationship between MYC gene numerical aberrations and protein expression in individuals from northern Brazil with early gastric adenocarcinoma
    Láuren Cláudia Costa Raiol
    Human Cytogenetics and Toxicological Genetics Laboratory, Institute of Biological Sciences, Federal University of Para, Campus Universitario do Guama, Av Augusto Correa, 01, CEP 66075 900, Belem, PA, Brazil
    Cancer Genet Cytogenet 181:31-5. 2008
    ..These novel findings concerning MYC copy number alteration in early gastric cancer suggest that MYC alteration is observed in the beginning of gastric carcinogenesis and could be used as a therapeutic target...
  47. pmc MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema
    Johanna Manner
    Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, D 68135 Mannheim, Germany
    Am J Pathol 176:34-9. 2010
    ..This finding may have implications both for the diagnosis and treatment of these tumors...
  48. pmc Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB
    Justin L Mott
    Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Cell Biochem 110:1155-64. 2010
    ..Thus, in addition to c-Myc, mir-29 expression can be suppressed by hedgehog signaling and inflammatory pathways, both commonly activated in the genesis of human malignancies...
  49. pmc Transcriptional regulation of Wnt inhibitory factor-1 by Miz-1/c-Myc
    J D F Licchesi
    Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Oncogene 29:5923-34. 2010
    ..Our data reveal novel insights into c-Myc-mediated DNA methylation-dependent transcriptional silencing, a mechanism that might contribute to the dysregulation of Wnt signaling in cancer...
  50. pmc The regulatory role of c-MYC on HDAC2 and PcG expression in human multipotent stem cells
    Dilli Ram Bhandari
    Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea
    J Cell Mol Med 15:1603-14. 2011
    ..From this finding, it can be concluded that c-MYC plays a vital role in cell proliferation and differentiation via chromosomal modification...
  51. pmc Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions
    Tianhua Guo
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Genes Chromosomes Cancer 50:25-33. 2011
    ..Secondary genetic hits, such as FLT4 gene coamplification or KDR mutations, may play a role in tumor progression as well as potential therapeutic targeting...
  52. ncbi The p400 complex is an essential E1A transformation target
    M Fuchs
    Dana Farber Cancer Institute, Boston, MA, USA
    Cell 106:297-307. 2001
    ..Furthermore, E1A and c-myc each alter the subunit composition of p400 complexes, implying that physiological p400 complex formation contributes to transformation suppression...
  53. doi Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine
    Andreas Höglund
    Department of Molecular Biology, Umea University, Umea, Sweden
    Blood 113:4281-8. 2009
    ..In vivo modeling of Myc-induced lymphoma suggests that decitabine constitutes a potential new drug against lymphoma that would selectively sensitize tumor cells but spare normal tissue...
  54. ncbi Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation
    Zhaohui Jin
    University of Florida Shands Cancer Center, Department of Medicine, University of Florida, Gainesville, Florida 32610 0232, USA
    J Biol Chem 279:40209-19. 2004
    ....
  55. ncbi A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
    Elizabeth Yeh
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Nat Cell Biol 6:308-18. 2004
    ..Thus, Ras-dependent signalling cascades ensure transient and self-limiting accumulation of c-Myc, disruption of which contributes to human cell oncogenesis...
  56. pmc MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation
    Gretchen Poortinga
    Division of Research, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, Australia
    EMBO J 23:3325-35. 2004
    ....
  57. ncbi The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors
    Sarah K Sjostrom
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Cell 9:327-38. 2005
    ..These findings provide a mechanism for promoting growth arrest in the final cycle of neural precursor proliferation competency, or for resetting the cell cycle in the G1 phase, by destabilizing N-myc in mitosis...
  58. pmc Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription
    Francesco Faiola
    Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA
    Mol Cell Biol 25:10220-34. 2005
    ..Our results suggest dual roles for p300/CBP in Myc regulation: as a Myc coactivator that stabilizes Myc and as an inducer of Myc instability via direct Myc acetylation...
  59. pmc Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc
    Dakang Xu
    Department of Immunology, Central and Eastern Clinical School, Monash University, AMREP, Prahran, Victoria 3181, Australia
    J Biol Chem 283:23567-80. 2008
    ....
  60. pmc HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma
    John D Gordan
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cancer Cell 14:435-46. 2008
    ..These reproducible distinctions in ccRCC behavior delineate HIF-alpha effects on c-Myc in vivo and suggest molecular criteria for selecting targeted therapies...
  61. pmc p63 regulates human keratinocyte proliferation via MYC-regulated gene network and differentiation commitment through cell adhesion-related gene network
    Ning Wu
    Commissariat a l Energie Atomique, Biologie à Grande Echelle, F 38054 Grenoble, France
    J Biol Chem 287:5627-38. 2012
    ..Furthermore, we show that the balance between the MYC-controlled cell cycle progression network and the p63-controlled cell adhesion-related network could dictate skin cell fate...
  62. pmc Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants
    Michael T Hemann
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 436:807-11. 2005
    ....
  63. pmc SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation
    Vanessa Brès
    Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
    Mol Cell 36:75-87. 2009
    ..Thus, SKIP acts with c-Myc and Menin to promote HIV-1 Tat:P-TEFb transcription at an elongation step that is bypassed under stress...
  64. pmc Global mapping of c-Myc binding sites and target gene networks in human B cells
    Karen I Zeller
    Department of Medicine and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:17834-9. 2006
    ....
  65. ncbi Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci
    Eva Bartova
    Laboratory of Molecular Cytology, Cytometry Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65, Brno, Czech Republic
    Differentiation 76:24-32. 2008
    ..Differentiated hES cells were characterized by a significantly different nuclear arrangement of the structures studied...
  66. ncbi Repression of p15INK4b expression by Myc through association with Miz-1
    P Staller
    Institute of Molecular Biology and Tumour Research, Emil Mannkopff Strabetae 2, 35033 Marburg, Germany
    Nat Cell Biol 3:392-9. 2001
    ..Alleles of c-myc that are unable to bind to Miz-1 fail to inhibit accumulation of p15INK4b messenger RNA in primary cells and are, as a consequence, deficient in immortalization...
  67. pmc Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression
    Asa Karlsson
    Department of Medicine, Division of Oncology, Stanford University, Stanford, CA 94305 5151, USA
    Proc Natl Acad Sci U S A 100:9974-9. 2003
    ..Hence, MYC overexpression may be a previously undescribed example of a dominant mutator that may fuel tumorigenesis by inducing chromosomal damage...
  68. ncbi PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation
    Mei Yu
    Abteilung Biochemie und Molekularbiologie, Institut fur Biochemie, Klinikum der RWTH, Pauwelsstrasse 30, 52057 Aachen, Germany
    Oncogene 24:1982-93. 2005
    ..Together, our findings define a novel PARP enzyme involved in the control of cell proliferation...
  69. pmc High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma
    Erik Fredlund
    Center for Molecular Pathology, Department of Laboratory Medicine, CREATE Health, University Hospital MAS, Lund University, SE 205 02 Malmo, Sweden
    Proc Natl Acad Sci U S A 105:14094-9. 2008
    ..These data suggest that pathway-specific gene expression profiling might be useful in the clinic to adjust treatment strategies for children with neuroblastoma...
  70. pmc MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas
    Ruimin Huang
    Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    FASEB J 25:4138-49. 2011
    ....
  71. doi TGF-beta induces growth arrest in Burkitt lymphoma cells via transcriptional repression of E2F-1
    Lindsay C Spender
    Growth Factor Signalling Laboratory, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, United Kingdom
    J Biol Chem 284:1435-42. 2009
    ..These data indicate that deregulation of c-MYC in lymphoma cells does not overcome the tumor suppressor function of TGF-beta and that repression of E2F-1 transcription is sufficient for the efficient induction of cytostasis...
  72. doi Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1
    L C Cobbold
    Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham, UK
    Oncogene 29:2884-91. 2010
    ....
  73. doi Bmi-1, c-myc, and Snail expression in primary breast cancers and their metastases--elevated Bmi-1 expression in late breast cancer relapses
    Kristiina Joensuu
    Department of Pathology, Haartman Institute, University of Helsinki, 00014 Helsinki, Finland
    Virchows Arch 459:31-9. 2011
    ..A significant association between the expression of Bmi-1 and estrogen receptor was found. Nuclear expression of c-myc in primary tumors correlated with an increased risk for axillary lymph node metastasis...
  74. ncbi Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis
    Marcelo L Larramendy
    Department of Pathology, Haartman Institute, Helsinki University Central Hospital, FIN 00014 University of Helsinki, Haartmaninkatu 3, Helsinki, Finland
    Haematologica 87:569-77. 2002
    ..Other molecular genetic changes are less well known. The novel cDNA technology has opened the avenue to large-scale gene expression analysis. Our aim was to perform cDNA microarray analysis of acute myeloid leukemia (AML)...
  75. ncbi Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms
    K Elliott
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Oncogene 18:3564-73. 1999
    ..These findings supported functional interaction between Myc and Bin1 in cells and indicated that Bin1 could inhibit malignant cell growth through multiple mechanisms...
  76. doi Myc regulates embryonic vascular permeability and remodeling
    Eniko Kokai
    Institute of Physiological Chemistry, Ulm University, Ulm, Germany
    Circ Res 104:1151-9. 2009
    ..Thus, the net outcome of an excess of vascular endothelial growth factor-A and angiopoietin-2 in the face of an elevated cellular turnover appears to be a defect in vascular integrity...
  77. ncbi Quadruplex-duplex competition in the nuclease hypersensitive element of human c-myc promoter: C to T mutation in C-rich strand enhances duplex association
    Kangkan Halder
    Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110007, India
    Biochem Biophys Res Commun 327:49-56. 2005
    ..2 and approximately 190.6 nM for M3 and P1, respectively). We envisage that the increased affinity for the duplex state due to the mutation could play a functional role in the aberrant regulation of c-myc...
  78. pmc Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia
    Renee M Demarest
    Molecular Oncology Program, Division of Surgical Oncology, Dewitt Daughtry Family Department of Surgery and University of Miami Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA
    Blood 117:2901-9. 2011
    ..These results demonstrate that T-ALL maintenance is dependent on NOTCH(IC), but not c-MYC, demonstrating that NOTCH is oncogenic dominant in T-ALL tumors...
  79. ncbi Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes
    Eva Ceballos
    Departamento de Biología Molecular y Unidad de Biomedicina CSIC, Grupo de Biología Molecular del Cáncer, Facultad de Medicina, University of Cantabria, Santander 39011, Spain
    Oncogene 24:4559-71. 2005
    ..Our data suggest that elevated levels of Myc counteract p53 activity in human tumor cells that lack ARF. This mechanism could contribute to explain the c-Myc deregulation frequently found in cancer...
  80. pmc A conserved Myc protein domain, MBIV, regulates DNA binding, apoptosis, transformation, and G2 arrest
    Victoria H Cowling
    Department of Pharmacology, Norris Cotton Cancer Center, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Mol Cell Biol 26:4226-39. 2006
    ..Thus, this conserved domain has an unexpected role in Myc DNA binding activity. These data also provide a novel separation of Myc functions linked to the modulation of DNA binding activity...
  81. ncbi E-cadherin repression contributes to c-Myc-induced epithelial cell transformation
    V H Cowling
    Department of Pharmacology, Dartmouth Medical School, Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Oncogene 26:3582-6. 2007
    ..E-cadherin expression is repressed by a post-transcriptional mechanism in cells expressing c-Myc. Furthermore, E-cadherin repression is necessary for c-Myc-induced cell transformation...
  82. doi MYC rearrangements are useful for predicting outcomes following rituximab and chemotherapy: multicenter analysis of Japanese patients with diffuse large B-cell lymphoma
    Minoru Kojima
    Division of Hematology Oncology, Department of Internal Medicine
    Leuk Lymphoma 54:2149-54. 2013
    ..In conclusion, our data suggest that fluorescence in situ hybridization (FISH) analysis for MYC-R can predict outcomes in response to rituximab-containing chemotherapy in Japanese patients with DLBCL...
  83. pmc Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells
    Jian Kang
    The Kinghorn Cancer Centre and Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, Sydney, NSW, Australia
    BMC Cancer 14:32. 2014
    ..Recent studies have identified several cell cycle kinases as MYC synthetic-lethal genes. We therefore investigated the therapeutic potential of specific cyclin-dependent kinase (CDK) inhibition in MYC-driven breast cancer...
  84. pmc Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer
    Stefano Cairo
    Oncogenesis and Molecular Virology Unit, Institut Pasteur, 75015 Paris, France
    Proc Natl Acad Sci U S A 107:20471-6. 2010
    ..Our data argue that Myc-driven reprogramming of miR expression patterns contributes to the aggressive phenotype of liver tumors originating from hepatic progenitor cells...
  85. ncbi Amplification of c-myc and cyclin D1 genes in primary and metastatic carcinomas of the liver
    Yoshihisa Takahashi
    Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan
    Pathol Int 57:437-42. 2007
    ..These results indicate that the amplification of the c-myc proto-oncogene is not unusual in HCC and MCA, and its detection may have a useful diagnostic significance in differentiating ICC from MCA or HCC from ICC...
  86. ncbi [Expression and significance of signal transducer and activator of transcription 3 and c-myc in laryngeal squamous cell carcinoma]
    Tingyan Liu
    Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 24:648-51. 2010
    ..To investigate the expression and clinical significance of signal transducer and activator of transcription 3(STAT3) and its target gene c-myc in laryngeal squamous cell carcinoma (LSCC), and the relationship between the two genes...
  87. ncbi Role of 14-3-3epsilon, c-Myc/Max, and Akt phosphorylation in HIV-1 gp 120-induced mesangial cell proliferation
    A A Kapasi
    Department of Medicine, Long Island Jewish Medical Center, The Long Island Campus for Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Am J Physiol Renal Physiol 280:F333-42. 2001
    ..These results suggest that HIV-1 gp 120 induces alterations in conflicting survival signaling pathways that contribute to the potential dual effects of gp 120 in promoting or inhibiting HMC proliferation...
  88. ncbi c-Myc-dependent etoposide-induced apoptosis involves activation of Bax and caspases, and PKCdelta signaling
    Ami Albihn
    Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Cell Biochem 98:1597-614. 2006
    ..Taken together, these findings suggest that Bax and caspase activation, together with PKCdelta signaling are involved in c-Myc-dependent etoposide-induced apoptosis...
  89. ncbi Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS
    Kelly D Hester
    Biomedical Sciences Graduate Program, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Cell Cycle 6:1594-604. 2007
    ....
  90. doi Stem cell-related proteins C-KIT, C-MYC and BMI-1 in juvenile nasopharyngeal angiofibroma--do they have a role?
    Suvi Renkonen
    Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Virchows Arch 458:189-95. 2011
    ....
  91. pmc The Pim protein kinases regulate energy metabolism and cell growth
    Zanna Beharry
    Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, Medical University of South Carolina, Charleston, SC 29425, USA
    Proc Natl Acad Sci U S A 108:528-33. 2011
    ..These results demonstrate the Pim kinase-mediated control of energy metabolism and thus regulation of AMPK activity. We identify an important role for Pim-3 in modulating c-Myc and PGC-1α protein levels and cell growth...
  92. doi MYC stimulates EZH2 expression by repression of its negative regulator miR-26a
    Sandrine Sander
    Institute of Physiological Chemistry, University of Ulm, Ulm, Germany
    Blood 112:4202-12. 2008
    ..Thus, in addition to directly targeting protein-coding genes, MYC modulates genes important to oncogenesis via deregulation of miRNAs, thereby vitally contributing to MYC-induced lymphomagenesis...
  93. pmc Identification of functional networks of estrogen- and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancer
    Elizabeth A Musgrove
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, Australia
    PLoS ONE 3:e2987. 2008
    ..Endocrine therapies targeting the estrogen receptor are effective in breast cancer, but their success is limited by intrinsic and acquired resistance...
  94. pmc "Myc'ed messages": myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron
    Hilary A Coller
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 3:e146. 2007
    ..We consider the possibility that members of this polycistronic microRNA cluster help cells to integrate signals from the environment and decide whether a signal should be interpreted as proliferative or apoptotic...
  95. pmc TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins
    Mikhail A Nikiforov
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544 1014, USA
    Mol Cell Biol 22:5054-63. 2002
    ..Nevertheless, L-Myc is a potent activator of several basally expressed genes and can fully restore the growth defect of myc-null cells. These results suggest a differential requirement for TRRAP for several Myc-mediated activities...
  96. ncbi c-MYC Asn11Ser is associated with increased risk for familial breast cancer
    Michael Wirtenberger
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, Heidelberg
    Int J Cancer 117:638-42. 2005
    ..Due to the pivotal role of c-MYC in diverse tumours, this variant might affect the genetic susceptibility of other cancers as well...
  97. pmc The c-myc insulator element and matrix attachment regions define the c-myc chromosomal domain
    Wendy M Gombert
    Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Mol Cell Biol 23:9338-48. 2003
    ..The MARs of the c-myc domain do not act to prevent the association of flanking regions with lysine 9-methylated histones, suggesting that they do not function as barrier elements...
  98. pmc The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc
    S B McMahon
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Mol Cell Biol 20:556-62. 2000
    ....
  99. pmc Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation
    S R Frank
    Department of Oncology, DNAX Research Institute, Palo Alto, California 94304, USA
    Genes Dev 15:2069-82. 2001
    ..Myc therefore governs a step, most likely H4 acetylation, that is required but not sufficient for transcriptional activation. We propose that Myc acts as a permissive factor, allowing additional signals to activate target promoters...
  100. ncbi Pag, a putative tumor suppressor, interacts with the Myc Box II domain of c-Myc and selectively alters its biological function and target gene expression
    Zhao Mei Mu
    Section of Hematology Oncology, The Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 277:43175-84. 2002
    ..These features, along with the previously identified interaction with c-Abl, provide support for the idea that Pag functions as a tumor suppressor...
  101. pmc c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation
    Xiaohui Liu
    Department of Biochemistry, University of California, Riverside 92521, USA
    J Biol Chem 278:20405-12. 2003
    ..Thus, TRRAP might function as an adaptor within the STAGA complex, which helps recruit GCN5 HAT activity to Myc during transcription activation...

Research Grants87

  1. NF-kappaB N-myc in Oncogenic Pathways of the CNS
    Raquel Sitcheran; Fiscal Year: 2010
    ..These studies have the potential to offer new insight into drug design targeting oncogenic pathways regulated by NF-KB and N-myc. ..
  2. Structure-based design of novel low molecular weight c-Myc inhibitors
    EDWARD VICTOR PROCHOWNIK; Fiscal Year: 2013
    ..abstract_text> ..
  3. Investigation of Myc Oncoprotein in B lymphocyte Development and Transformation
    Brian M Iritani; Fiscal Year: 2012
    ..Experiments described in this proposal will utilize transgenic and knockout mice to help elucidate the normal functions of Myc in lymphocyte development, and how deregulated Myc potently stimulates cells to divide in cancer. ..
  4. Andrei Goga; Fiscal Year: 2014
    ..The knowledge gained from these studies will facilitate the development of new therapeutics that target tumor cells with particular genetic changes by precisely inhibiting the cell division cycle. ..
  5. Interplay of Myc, Tumor Supressors and Regulators of Differentiation in Lymphoma
    John L Cleveland; Fiscal Year: 2012
    ..Since Myc oncoproteins are activated in up to 70% of all cancers, our discoveries may provide the foundation for developing new agents that are broadly effectively in cancer prevention and treatment. ..
  6. Chi V Dang; Fiscal Year: 2016
    ....
  7. Analysis of the Human c-myc Gene Replication Origin
    Michael Leffak; Fiscal Year: 2012
    ..Thus, our studies are likely to provide fundamental new insight into the mechanisms of DNA replication, the origins of genetic diseases, and new models for disease treatment. ..
  8. Investigation of a novel regulator of Myc-driven tumorigenesis
    Mark W Gramling; Fiscal Year: 2012
    ..Our studies should also define the potential of MTBP and its interacting factors as therapeutic targets in Myc driven malignancies. ..
  9. Functional analysis of transcriptional program regulated by the c-MYC oncoprotein
    Steven B McMahon; Fiscal Year: 2012
    ..each year. Understanding the cellular changes induced by MYC will provide us with novel targets for therapeutic intervention in these patients. The studies proposed here are aimed at a precise mechanistic delineation of the MYC pathway. ..
  10. ROBERT NEIL EISENMAN; Fiscal Year: 2016
    ..Importantly, myc genes are mutated and deregulated in a very wide range of human cancers. Detailed knowledge of the molecular functions of myc will be critical for detection, diagnosis and treatment of human cancers. ..
  11. David A Thorley-Lawson; Fiscal Year: 2016
    ..It will also have the direct clinical implication that intervention to reduce the malarial burden and the ability of malarial antigens to trigger AID could dramatically reduce the incidence of an important childhood lymphoma - eBL. ..
  12. Carol E Schrader; Fiscal Year: 2014
    ..We will investigate what makes these other sites targets for AID, and for DNA break formation. Thus our studies will also shed light on the important question of how AID chooses its targets. ..
  13. Xin Li; Fiscal Year: 2014
    ..e. those with PIN or high-grade PIN). The novel combined cancer prevention therapy using metformin and mTOR inhibitors proposed in this study may display promising synergistic efficacy and will be translational to clinical application. ..
  14. A Mouse Model for the Rare Plasma Cell Disease AL Amyloidosis
    David C Seldin; Fiscal Year: 2010
    ..abstract_text> ..
  15. Mapping the functional major histocompatibility complex genes in zebrafish
    JILL L DE JONG; Fiscal Year: 2012
    ..Discovery of the functional MHC genes would open the door for zebrafish researchers studying many aspects of transplantation and vertebrate biology. ..
  16. Coordinate Regulation of p53 and c-MYC in an HTLV-1 Model of Carcinogenesis
    Robert L Harrod; Fiscal Year: 2012
    ..This R15 AREA project will provide excellent cancer research training opportunities for undergraduates and graduate students to better prepare them for future careers in the basic or clinical oncological sciences. ..
  17. Anil K Rustgi; Fiscal Year: 2016
    ..Our studies hope to reveal new paradigms in CRC pathogenesis, and offer opportunities for exploiting this knowledge in novel diagnostics and therapeutics. ..
  18. Temporally controlled oncogene expression in a novel pancreatic cancer model
    Kay Uwe Wagner; Fiscal Year: 2012
    ....
  19. "Oncorequisite" Genes in MYC-mediated Transformation
    Hui Feng; Fiscal Year: 2010
    ..By identifying mutant genes that delay the onset of Myc-driven T-cell leukemia in fish, this project seeks to discover molecules that could serve as useful targets for therapeutic intervention in human cancers. ..
  20. MICHAEL DAVID COLE; Fiscal Year: 2014
    ..The goal of the project is to understand how mutations change c-myc function in some cancers and how inherited variations near c-myc in the human genome can increase the risk of cancer. ..
  21. Comparative Mechanisms of Genomic Instability
    Karen M Vasquez; Fiscal Year: 2010
    ..These discoveries should begin to unravel the pathogenesis of diseases that are caused by genomic instability, and ultimately to the development of new approaches for treatment and prevention. ..
  22. Hybridization of Promoter DNA Targets in Chromatin to Discover Regulatory Protein
    LINDA B MC GOWN; Fiscal Year: 2010
    ....
  23. David M Hockenbery; Fiscal Year: 2016
    ....
  24. Targeting c-Myc and Akt with PP2A reactivation therapy for the treatment of breas
    Dale J Christensen; Fiscal Year: 2013
    ....
  25. Hui Feng; Fiscal Year: 2014
    ..The rationale and feasibility of this approach are well-illustrated by my data acquired during the K99 phase. ..
  26. Identification and Characterization of Liver Cancer Stem Cells
    DAVID BELLOVIN; Fiscal Year: 2010
    ..The ultimate consequences of this study would be to gain insight into the development of liver cancer, while potentially identifying novel therapeutic targets for this especially lethal disease. ..
  27. Zebrafish Chemical and Classical Genetics Approach to the Pathogenesis of T-ALL
    Alejandro Gutierrez; Fiscal Year: 2012
    ....
  28. Disruption of HLA Class II-Mediated Immune Recognition of B-Cell Lymphomas
    Azizul Haque; Fiscal Year: 2013
    ..The elucidated findings will likely spur development of novel strategies to restore CD4+ T cell recognition and clearance of BL and other B-cell lymphomas. ..
  29. ERICH SABIO; Fiscal Year: 2014
    ..Due to the extensive association between miRNA dysregulation and cancer, the valuable insights we will gain through these studies will have a broad impact on global health. ..
  30. Yanxin Pei; Fiscal Year: 2014
    ..If these studies are successful, they will help identify novel approaches to preventing tumor relapse in MYC-driven MB and other malignancies. ! ..
  31. Besim Ogretmen; Fiscal Year: 2016
    ..Moreover, these studies will lead to the development of mechanism-based novel therapeutic strategies for improved NSCLC treatment to selectively inhibit oncogenic SK2/S1P/hTERT/c-Myc axis without affecting telomere-length regulation. ..
  32. C-MYC EXPRESSION AND APOPTOSIS IN B CELLS
    GAIL SONENSHEIN; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page .................................................................................................................................................. 1 Description, ..
  33. OLIGONUCLEOTIDE INHIBITION OF CELL PROLIFERATION
    Eric Wickstrom; Fiscal Year: 2000
    ..The lead compounds resulting from these studies will then be translated to a separate collaborative application for a Phase I/II clinical trial. ..
  34. TSHR and thyrocyte development
    Reigh Yi Lin; Fiscal Year: 2013
    ..The goal of this project is to combine the advantages of embryonic stem cells and induced pluripotent stem cells with the powerful genetic tools available in mouse models to take a unique approach to thyroid development and disease. ..
  35. FOXP3-microRNA146-NFkB Axis in Tumor Suppression
    Lizhong Wang; Fiscal Year: 2013
    ..abstract_text> ..
  36. Regulation of apoptosis by PI 3-kinase/Akt signaling
    Geoffrey M Cooper; Fiscal Year: 2012
    ..The present proposal seeks to further understand the mechanism by which this pathway regulates cell survival. Discoveries of novel targets of PI 3-kinase signaling may provide new targets for cancer treatment. ..
  37. Development of Ets2-Inhibitors
    DEV ARYA; Fiscal Year: 2009
    ..Using neomycin's ability to stabilize triplexes and deliver TFOs, neomycin-TFO (PS) conjugates will be developed as triplex-forming anticancer agents. ..
  38. Regulation and Role of Ornithine Decarboxylase in Cell Proliferation and Cancer
    John L Cleveland; Fiscal Year: 2013
    ..abstract_text> ..
  39. MYC ONCOPROTEIN FUNCTION
    ROBERT NEIL EISENMAN; Fiscal Year: 2013
    ..1 Description, ..
  40. MATTHEW THOMAS HURD; Fiscal Year: 2014
    ..Various methods, including chromatin immunoprecipitation (ChIP) assays, RNA interference (RNAi), and reporter gene assays will be used. ..
  41. Opposing and complementary roles of KLF1 and KLF2 in erythropoiesis
    Joyce A Lloyd; Fiscal Year: 2012
    ..abstract_text> ..
  42. The Oncogenic Significance of Cyclin Overexpression and Smad 3 Tumor Suppression
    Jacqueline Sara Jeruss; Fiscal Year: 2012
    ..Therapeutic targeting of CDK/cyclin activity to restore Smad 3 tumor suppression may hold promise for patients with cyclin overexpressing and basal-like breast cancers, who currently have the disease sub-type with the worst prognosis. ..
  43. Analyses of the Molecular Functions for D-Cyclins
    Peter Sicinski; Fiscal Year: 2013
    ..cancer patients is entertained: (1) Are D-cyclins required for normal cell proliferation and function in the adult organism? (2) Would blocking cyclin D function in oncogenically transformed cells revert the oncogenic transformation? ..
  44. Functions of an E1A-Associated Cellular Protein
    Bayar Thimmapaya; Fiscal Year: 2010
    ..abstract_text> ..
  45. Sarah K Nelson; Fiscal Year: 2016
    ..Following the completion of my Ph.D. degree, I will return to the University Of Colorado School Of Medicine to complete my medical coursework and clinical rotations. ..
  46. Directed Evolution of Peptide Inhibitors of Myc-Max Dimerization (PQ18)
    ROBERT NEIL EISENMAN; Fiscal Year: 2013
    ..directed evolution and biological validation, we will assess the molecular and functional mechanisms of inhibition to ensure protein specificity and therapeutic efficacy in reducing levels of activated Myc and attenuating tumor growth ..
  47. c-Myc Phosphorylation Sites Regulate Its Apoptotic and Tumorigenic Potential
    Rosalie C Sears; Fiscal Year: 2012
    ....
  48. DANIEL A BARRON; Fiscal Year: 2015
    ..Such information is vital to understanding the contribution of Dlc1 to human carcinogenesis and may provide new opportunities to develop targeted therapies for cancers with deregulated Dlc1. ..
  49. A model system to study the tumor suppressor APC and its role in Wnt regulation.
    David Roberts; Fiscal Year: 2013
    ..Thus we can take advantage of the speed of this simpler genetic model system to investigate questions important to the progression and treatment of human colon cancer. ..
  50. Kinetic Analysis of Myc-induced carcinogenesis in vivo
    GERARD IAN EVAN; Fiscal Year: 2012
    ..abstract_text> ..
  51. c-Myc transcription in intestinal growth, differentiation, and carcinogenesis
    Gregory S Yochum; Fiscal Year: 2012
    ..Our studies address the fundamental mechanisms underlying b-catenin regulation of normal gastrointestinal development and homeostasis as well as the pathogenesis of intestinal malignancy. ..
  52. Ina Dobrinski; Fiscal Year: 2016
    ....
  53. Structure and function of the U3 RNA-protein complex
    Carl C Correll; Fiscal Year: 2010
    ....
  54. ANGELA NICOLE KOEHLER; Fiscal Year: 2015
    ....
  55. TAS::75 0849::TAS IN THIS PHASE I SBIR THE BREAST CANCER ADENOCARCINOMA CELL LI
    Shaharyar Khan; Fiscal Year: 2010
    ..Gencia has developed a recombinant form of human TFAM, the mitochondrial transcription factor A (rhTFAM), modified to allow it to traverse cellular barriers and to be specifically imported into the mitochondria. ..
  56. The Role of HNF4alpha in Cell Proliferation
    Linh Vuong; Fiscal Year: 2013
    ..These two systems will provide complementary approaches to address the fundamental dichotomy between cell proliferation and cell differentiation in liver development and disease. ..
  57. The Role of OTX2 in Molecular Pathogenesis of Medulloblastoma
    Hai Yan; Fiscal Year: 2010
    ....
  58. Joan Massague; Fiscal Year: 2014
    ..Building on this progress, we will investigate the connectivity and regulation of TGF-beta and BMP pathways with other major regulators of cell behavior in the normal and the malignant state. ..
  59. BLAIR BERNARD MADISON; Fiscal Year: 2016
    ..Determining how LIN28B functions in the intestinal crypt will likely provide an important link among the cellular mechanisms governing epithelial proliferation, differentiation, and/or mucosal regeneration. ..
  60. Mechanisms of the hypoxic response underlying tumor progression
    L Eric Huang; Fiscal Year: 2012
    ..We anticipate this study will help define the molecular basis for the development of novel therapeutics. ..
  61. CONTROL OF PROSTATE-SPECIFIC GENE EXPRESSION
    Robert J Matusik; Fiscal Year: 2013
    ....
  62. Iannis Aifantis; Fiscal Year: 2014
    ..Our studies have direct translational impact as they address the function of a central regulator of HSC ability to replenish the immune system that at the same time functions as a tumor suppressor in leukemia. ..
  63. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  64. David J Shapiro; Fiscal Year: 2014
    ..Microarray studies using IMP-1 negative cells will assess possible off-target effects of the lead inhibitor. Lead structures will be confirmed, leads resynthesized and structural studies of inhibitor bound to IMP-1 will be initiated. ..
  65. OLGA ANCZUKOW-CAMARDA; Fiscal Year: 2014
    ..This plan will establish the basis for my independent research program, in which I plan to contribute to the development of new cancer therapies based on modulating the expression and activity of splicing factors or their targets. ..
  66. ASISH KUMAR GHOSH; Fiscal Year: 2016
    ....
  67. Gregory B Lesinski; Fiscal Year: 2016
    ..These studies will provide a comprehensive, translational understanding of how dietary soy and its isoflavone components modulate aspects of immunity relevant to prostate cancer development and progression. ..
  68. LONING NONE FU; Fiscal Year: 2014
    ..Our studies will lead to a better understanding of the mechanism of cancer and to the development of novel therapeutic strategies for cancer prevention and treatment. ..
  69. Ronald B Gartenhaus; Fiscal Year: 2015
    ....
  70. c-Myc, growth factor and breast cancer
    Dezhong Liao; Fiscal Year: 2007
    ..abstract_text> ..
  71. Xin Li; Fiscal Year: 2016
    ..The outcomes of our study are expected to have exceptionally high potential to re- shape current key concept and paradigms about the role of metformin in prostate cancer treatment. ..
  72. Role of B-cell oncogenes and microRNA-34 in B-lymphopoiesis and neoplasia
    Dinesh S Rao; Fiscal Year: 2013
    ..Hence, these studies have a direct relevance to public health and most importantly, to patients living with these diseases. ..
  73. Fnip1 Function in Lymphocyte Development, Activation and Metabolism
    Brian M Iritani; Fiscal Year: 2013
    ..abstract_text> ..
  74. The LIN28b-Let7 axis in intestinal epithelial biology
    Anil K Rustgi; Fiscal Year: 2013
    ....
  75. JURGEN T ROHR; Fiscal Year: 2016
    ..New resulting MTM analogues will be submitted to the NCI DTP (developmental therapeutics program) for further mechanistic investigations. ..
  76. Xuefeng Liu; Fiscal Year: 2014
    ..These studies will provide new insights into a basic event in the etiology of cancer. ..
  77. Joshua T Mendell; Fiscal Year: 2015
    ....
  78. Live cell imaging of IgH and c-Myc gene loci and the role of nuclear organization
    Mark T Groudine; Fiscal Year: 2010
    ..We will first determine the mechanism by which these gene loci interact with transcription factories and then determine if forcibly separating the two loci decreases the frequency of their translocations. ..
  79. Modulation of c-MYC Functions in an HTLV-1 Model for Carcinogenesis
    Robert Harrod; Fiscal Year: 2009
    ..These studies may lead to the development of targeted therapeutic strategies to inhibit c-MYC oncogenic functions in hematological malignancies and solid tumors. ..
  80. Role for DKC1 in cell proliferation and transformation
    Faizan Alawi; Fiscal Year: 2009
    ..Identifying DKC1 as an essential effector of c-MYC-mediated tumorigenesis may also lead to new targeted therapies for c-MYC-positive tumors. ..
  81. ELAV-LIKE PROTEINS IN NEUROBLASTOMA
    Susan Cohn; Fiscal Year: 2000
    ..Thus, ultimately, these studies may provide the clues necessary for the development of effective therapy for children with NB tumors that express high levels of N-myc and are clinically aggressive. ..