c-Met

Summary

Gene Symbol: c-Met
Description: MET proto-oncogene, receptor tyrosine kinase
Alias: AUTS9, DFNB97, HGFR, RCCP2, c-Met, hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, SF receptor, proto-oncogene c-Met, scatter factor receptor, tyrosine-protein kinase Met
Species: human

Top Publications

  1. ncbi c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis
    Yu Nakamura
    Department of Human Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 98:1006-13. 2007
  2. pmc Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
    Pal Kaposi-Novak
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:1582-95. 2006
  3. pmc Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer
    Erika M Wolff
    Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS Genet 6:e1000917. 2010
  4. doi Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells
    David L Shattuck
    University of California Davis Cancer Center, Sacramento, CA 95817, USA
    Cancer Res 68:1471-7. 2008
  5. pmc Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Autism Res 1:159-68. 2008
  6. doi A direct role for Met endocytosis in tumorigenesis
    Carine Joffre
    Spatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Nat Cell Biol 13:827-37. 2011
  7. ncbi Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration
    Mayra Yebra
    Department of Pediatrics, The Whittier Institute for Diabetes, University of California, San Diego, La Jolla, CA 92037, USA
    Dev Cell 5:695-707. 2003
  8. doi Nuclear localization of active HGF receptor Met in aggressive MDA-MB231 breast carcinoma cells
    Emanuela Matteucci
    Dipartimento di Morfologia Umana e Scienze Biomediche Città Studi, University of Milan, Italy
    Carcinogenesis 30:937-45. 2009
  9. doi HGF/c-Met overexpressions, but not met mutation, correlates with progression of non-small cell lung cancer
    Mukaddes Gumustekin
    Department of Pharmacology, Dokuz Eylul University Medical School, Inciralti, 35340, Izmir, Turkey
    Pathol Oncol Res 18:209-18. 2012
  10. doi Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder
    Pamela B Jackson
    JC Self Research Institute of Human Genetics, Greenwood Genetic Center, Greenwood, South Carolina, USA
    Autism Res 2:232-6. 2009

Research Grants

  1. Trophokine for regenerative medicine
    Jianmin Fang; Fiscal Year: 2010
  2. HGF/HGFR Axis and Fatty Liver Disease
    Reza Zarnegar; Fiscal Year: 2013
  3. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2010
  4. Novel Small Molecules For Acute Liver Failure
    Prakash Narayan; Fiscal Year: 2009
  5. SOMATIC CELL TRANSFER TO MODEL MEDULLOBLASTOMA IN MICE
    DANIEL WEBSTER FULTS; Fiscal Year: 2013
  6. HGF Signaling in Kidney Repair
    Lloyd G Cantley; Fiscal Year: 2012
  7. Safety and efficacy of optimized AAV3 vectors in murine and NHP livers
    Arun Srivastava; Fiscal Year: 2013
  8. Reza Zarnegar; Fiscal Year: 2015
  9. Mechanism of Host Cell Invasion by Microbial Pathogens
    Partho Ghosh; Fiscal Year: 2010
  10. Anti-Fibrotic Therapy for Pulmonary Fibrosis
    Latha Paka; Fiscal Year: 2007

Detail Information

Publications345 found, 100 shown here

  1. ncbi c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis
    Yu Nakamura
    Department of Human Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 98:1006-13. 2007
    ..c-Met activation may play special roles in the papillary subtype and in well differentiated lung adenocarcinomas...
  2. pmc Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
    Pal Kaposi-Novak
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:1582-95. 2006
    ....
  3. pmc Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer
    Erika M Wolff
    Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS Genet 6:e1000917. 2010
    ..These data show that, in addition to contributing to chromosomal instability, hypomethylation of LINE-1s can alter the functional transcriptome and plays a role not only in human disease but also in disease predisposition...
  4. doi Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells
    David L Shattuck
    University of California Davis Cancer Center, Sacramento, CA 95817, USA
    Cancer Res 68:1471-7. 2008
    ..Our study suggests that a subset of Her2 (+) patients may benefit from combined inhibition of Her2 and Met...
  5. pmc Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Autism Res 1:159-68. 2008
    ..These data further support our hypothesis that genetic susceptibility impacting multiple components of the MET signaling pathway contributes to ASD risk...
  6. doi A direct role for Met endocytosis in tumorigenesis
    Carine Joffre
    Spatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Nat Cell Biol 13:827-37. 2011
    ..Thus, oncogenicity of Met mutants results not only from activation but also from their altered endocytic trafficking, indicating that endosomal signalling may be a crucial mechanism regulating RTK-dependent tumorigenesis...
  7. ncbi Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration
    Mayra Yebra
    Department of Pediatrics, The Whittier Institute for Diabetes, University of California, San Diego, La Jolla, CA 92037, USA
    Dev Cell 5:695-707. 2003
    ..These results provide evidence for the activation of epithelial cell adhesion and migration by a neural chemoattractant, and identify Netrin-1/integrin interactions as adhesive/guidance cues for epithelial cells...
  8. doi Nuclear localization of active HGF receptor Met in aggressive MDA-MB231 breast carcinoma cells
    Emanuela Matteucci
    Dipartimento di Morfologia Umana e Scienze Biomediche Città Studi, University of Milan, Italy
    Carcinogenesis 30:937-45. 2009
    ..Wwox/Met system can be suggested as a potential target to impair breast carcinoma progression...
  9. doi HGF/c-Met overexpressions, but not met mutation, correlates with progression of non-small cell lung cancer
    Mukaddes Gumustekin
    Department of Pharmacology, Dokuz Eylul University Medical School, Inciralti, 35340, Izmir, Turkey
    Pathol Oncol Res 18:209-18. 2012
    ..The blockade of the HGF/c-Met pathway with RhoA and/or TIMP-3 inhibitors may be an effective therapeutic target for NSCLC treatment...
  10. doi Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder
    Pamela B Jackson
    JC Self Research Institute of Human Genetics, Greenwood Genetic Center, Greenwood, South Carolina, USA
    Autism Res 2:232-6. 2009
    ..20; 95% CI=0.56-2.56; chi(2)=0.2, df=1, P=0.64). This study is the third independent study to find the rs1858830 C variant in the MET gene promoter to be associated with autism...
  11. pmc Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells
    Shumin Zhang
    Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    Mol Cancer 9:9. 2010
    ..Mcl-1 overexpression has been associated with progression in leukemia and some solid tumors including prostate cancer (PCa). However, the regulatory mechanism for Mcl-1 expression in PCa cells remains elusive...
  12. doi Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer
    Francesco Graziano
    Azienda Ospedaliera Ospedali Riuniti Marche Nord 61122, Pesaro, Italy
    J Clin Oncol 29:4789-95. 2011
    ..To investigate whether prognosis of patients with high-risk gastric cancer may depend on MET copy number gain (CNG) or an activating truncation within a deoxyadenosine tract element (DATE) in the promoter region of the MET ligand HGF...
  13. pmc Ligand-independent activation of c-Met by fibronectin and α(5)β(1)-integrin regulates ovarian cancer invasion and metastasis
    A K Mitra
    Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, Center for Integrative Science, University of Chicago, Chicago, IL 60637, USA
    Oncogene 30:1566-76. 2011
    ..These data suggest that fibronectin promotes ovarian cancer invasion and metastasis through an α(5)β(1)-integrin/c-Met/FAK/Src-dependent signaling pathway, transducing signals through c-Met in an HGF/SF-independent manner...
  14. ncbi Hepatocyte growth factor receptor, matrix metalloproteinase-11, tissue inhibitor of metalloproteinase-1, and fibronectin are up-regulated in papillary thyroid carcinoma: a cDNA and tissue microarray study
    Veli Matti Wasenius
    Department of Oncology, Helsinki University Central Hospital, FIN 00029 Helsinki, Finland
    Clin Cancer Res 9:68-75. 2003
    ....
  15. ncbi The overexpression of c-met as a prognostic indicator for gastric carcinoma compared to p53 and p21 nuclear accumulation
    Uta Drebber
    Institute of Pathology, University of Cologne, Cologne, Germany
    Oncol Rep 19:1477-83. 2008
    ..P21 proved to be a significant prognostic factor in the multivariate analysis. Our data suggest that the overexpression of c-met and p21 may represent independent prognostic factors in gastric carcinoma...
  16. pmc Expression and mutational analysis of MET in human solid cancers
    Patrick C Ma
    Division of Hematology Oncology, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Genes Chromosomes Cancer 47:1025-37. 2008
    ..MET would be an important therapeutic antitumor target to be inhibited, and in lung cancer, MET may represent a cancer early progenitor cell marker...
  17. pmc c-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2
    Maggie K S Tang
    School of Biological Sciences, The University of Hong Kong, Hong Kong, China
    Neoplasia 12:128-38. 2010
    ..These findings shed new light on the apoptotic resistance mechanism of nonadherent ovarian cancer ascites cells and may have important clinical implications...
  18. ncbi c-Met ectodomain shedding rate correlates with malignant potential
    Gagani Athauda
    Urologic Oncology Branch, Laboratory of Molecular Pharmacology, and Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892 1107, USA
    Clin Cancer Res 12:4154-62. 2006
    ..We hypothesized that c-Met overexpression in cancer might result in increased ectodomain shedding, and that its measure could be a useful biomarker of tumor progression...
  19. pmc LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy
    David L Shattuck
    UC Davis Cancer Center, Research Building III, Room 1400, 4645 2nd Ave, Sacramento, CA 95817, USA
    Mol Cell Biol 27:1934-46. 2007
    ..We conclude that LRIG1 is a novel suppressor of Met function, serving to regulate cellular receptor levels by promoting Met degradation in a ligand- and cbl-independent manner...
  20. pmc RET/PTC1-driven neoplastic transformation and proinvasive phenotype of human thyrocytes involve Met induction and beta-catenin nuclear translocation
    Giuliana Cassinelli
    Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Neoplasia 11:10-21. 2009
    ..Such molecular network, promoting disease initiation and acquisition of a proinvasive phenotype, highlights new options to design multitarget therapeutic strategies for PTCs...
  21. pmc PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription
    Rajani Kanteti
    Department of Hematology Oncology, University of Chicago Medical Center, Chicago, IL 60637, USA
    Lab Invest 89:301-14. 2009
    ..Therefore, we propose that PAX5 could be an important regulator of c-Met transcription and a potential target for therapy in SCLC...
  22. doi Abnormality of the hepatocyte growth factor/MET pathway in pulmonary adenocarcinogenesis
    Keisei Tachibana
    Department of Surgery, Institute of Medical Sciences, Kyorin University, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Lung Cancer 75:181-8. 2012
    ..Here we investigated the copy number of the MET gene and expression of MET and HGF in small pulmonary adenocarcinomas...
  23. doi Increased TGF-α as a mechanism of acquired resistance to the anti-EGFR inhibitor cetuximab through EGFR-MET interaction and activation of MET signaling in colon cancer cells
    Teresa Troiani
    Authors Affiliations Oncologia Medica and Immunologia Clinica, Dipartimento Medico Chirurgico di Internistica Clinica e Sperimentale F Magrassi e A Lanzara Sezione di Farmacologia, Dipartimento di Medicina Sperimentale, Seconda Università degli Studi di Napoli and Oncologia Medica, Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Universita di Napoli Federico II, Naples, Italy
    Clin Cancer Res 19:6751-65. 2013
    ..Although cetuximab, an anti-EGF receptor (EGFR) monoclonal antibody, is an effective treatment for patients with KRAS wild-type metastatic colorectal cancer (mCRC), its clinical use is limited by onset of resistance...
  24. doi Co-existence of positive MET FISH status with EGFR mutations signifies poor prognosis in lung adenocarcinoma patients
    Aya Tanaka
    Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Lung Cancer 75:89-94. 2012
    ..These results suggest that MET FISH is a potential prognostic factor and coexistence of MET FISH with EGFR mutations signifies worse prognosis...
  25. doi High MET copy number and MET overexpression: poor outcome in non-small cell lung cancer patients
    Sanghui Park
    Department of Pathology, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea
    Histol Histopathol 27:197-207. 2012
    ..618; 95% confidence interval, 1.066-2.456; p=0.024). Increased MET copy number and MET overexpression are negative prognostic factors for surgically resected NSCLCs...
  26. pmc An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis
    Marion Zillhardt
    Department of Obstetrics, University of Chicago, Chicago, IL 60637, USA
    Neoplasia 12:1-10. 2010
    ..Overall, these data indicate that PF-2341066 effectively reduces tumor burden in an in vivo model of ovarian cancer metastasis and may be a good therapeutic candidate in the treatment of patients with ovarian cancer...
  27. pmc Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis
    Elisa Benedettini
    Department of Medical Oncology, the Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston Massachusetts, USA
    Am J Pathol 177:415-23. 2010
    ..If confirmed in larger cohorts, our analysis suggests that patient tumors harboring both Met activation and EGFR mutation could potentially benefit from early intervention with a combination of EGFR and Met inhibitors...
  28. pmc cMET and phospho-cMET protein levels in breast cancers and survival outcomes
    Kanwal P Raghav
    Department of Hematology Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 18:2269-77. 2012
    ..To evaluate cMET (mesenchymal-epithelial transition factor gene) and phospho-cMET (p-cMET) levels in breast cancer subtypes and its impact on survival outcomes...
  29. doi Further evidence for the role of MET in autism susceptibility
    Ismail Thanseem
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, Shizuoka 431 3192, Japan
    Neurosci Res 68:137-41. 2010
    ..4 kb. Our results provide further evidence for a possible role of MET in the pathogenesis of ASD...
  30. doi Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer
    Katsuhiro Okuda
    Department of Oncology, Nagoya City University Graduate School of Medical Science, Nagoya, Japan
    Cancer Sci 99:2280-5. 2008
    ..However, the results support a critical role of Met gene dose in NSCLC, suggesting that Met may be a specific molecular therapeutic target in selected NSCLC patients with increased Met copy number...
  31. pmc MET and autism susceptibility: family and case-control studies
    Ines Sousa
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Eur J Hum Genet 17:749-58. 2009
    ..02). The previously reported positive association of rs1858830 failed to replicate in this study. Overall, our findings provide further evidence that MET may play a role in autism susceptibility...
  32. doi Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells
    M R Finkbeiner
    Laboratory for Oncogenomic Research, Departments of Pediatrics and Experimental Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Oncogene 28:1421-31. 2009
    ..Finally, silencing YB-1 or MET attenuated anchorage-independent growth of BLBC cell lines. Together, these findings implicate MET as a target of YB-1 that work in concert to promote BLBC growth...
  33. pmc Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors
    M Park
    Proc Natl Acad Sci U S A 84:6379-83. 1987
    ..We conclude from these results that the MET protooncogene is a cell-surface receptor for an as-yet-unknown ligand...
  34. pmc Wild-type p53 controls cell motility and invasion by dual regulation of MET expression
    Chang Il Hwang
    Department of Biomedical Sciences, Microarray Core Facility, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 108:14240-5. 2011
    ..These results also show that the extent of advanced cancer traits, such as invasion, may be determined by alterations in individual components of p53/MET regulatory network...
  35. doi c-MET/phospho-MET protein expression and MET gene copy number in non-small cell lung carcinomas
    Koji Tsuta
    Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 7:331-9. 2012
    ..The aim of this study was to examine the correlations between c-MET/phospho-MET expression as well as MET gene copy number alterations and overall survival (OS) in non-small cell lung carcinomas (NSCLCs)...
  36. doi Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells
    Koji Kawaguchi
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, Japan
    Carcinogenesis 30:1097-105. 2009
    ....
  37. pmc Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase
    Veena Sangwan
    Department of Biochemistry, McGill University, Canada
    J Biol Chem 283:34374-83. 2008
    ..We have identified PTP1B and TCPTP as negative regulators of the hepatocyte growth factor receptor, the Met receptor-tyrosine kinase...
  38. ncbi The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein
    G Pelicci
    Istituto di Clinica Medica 1, University of Perugia, Italy
    Oncogene 10:1631-8. 1995
    ..After ligand-induced tyrosine phosphorylation, the HGF receptor associates with the Shc adaptor, via the SH2 domain...
  39. ncbi Prevalence and clinical impact of Met Y1253D-activating point mutation in radiotherapy-treated squamous cell cancer of the oropharynx
    Daniel M Aebersold
    Department of Radiation Oncology, Inselspital Bern, Switzerland
    Oncogene 22:8519-23. 2003
    Aberrant signalling through the hepatocyte growth factor/scatter factor receptor Met has been implicated in various aspects of the development of human cancer including the promotion of tumour invasion, angiogenesis and metastasis...
  40. pmc Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage
    David Tulasne
    CNRS UMR 8117, Institut de Biologie de Lille, Institut Pasteur de Lille, B P 447, 59021 Lille, France
    Mol Cell Biol 24:10328-39. 2004
    ..Finally, HGF/SF treatment does not favor MET cleavage and apoptosis, confirming the known survival role of ligand-activated MET. Our results show that stress stimuli convert the MET survival receptor into a proapoptotic factor...
  41. ncbi HGF and c-MET as potential orchestrators of invasive growth in head and neck squamous cell carcinoma
    Maria Jantine De Herdt
    Department of Otolaryngology and Head and Neck Surgery, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 300 CA Rotterdam, The Netherlands
    Front Biosci 13:2516-26. 2008
    ..It is concluded that both molecules are mis- and over-expressed in HNSCC and probably induce the program of invasive growth in HNSCC...
  42. ncbi [Expression of c-erbB-2 and c-met proteins in gastric adenoma and adenocarcinoma]
    Seung Woo Lee
    Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea
    Korean J Gastroenterol 49:152-7. 2007
    ....
  43. doi MET receptor tyrosine kinase as a therapeutic anticancer target
    Christine M Stellrecht
    Department of Experimental Therapeutics, Unit 71, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Cancer Lett 280:1-14. 2009
    ..Numerous agents have been developed that are able to target MET expression and/or function and are the focus of this review...
  44. doi MET overexpressing chordomas frequently exhibit polysomy of chromosome 7 but no MET activation through sarcoma-specific gene fusions
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Tumour Biol 31:157-63. 2010
    ..A clear influence of polysomy 7 on MET protein expression could not be statistically demonstrated for this cohort. Moreover, gene fusions with the ability to cause MET overexpression do not occur in chordomas...
  45. doi [Prognostic value of MACC1 and c-met expressions in non-small cell lung cancer]
    Xingsheng Hu
    Department of Oncology, The Second Affiliated Hospital of North Sichuan Medical College, Nanchong, China
    Zhongguo Fei Ai Za Zhi 15:399-403. 2012
    ..The aim of this study is to explore the expressions of MACC1 and hepatocyte growth factor receptor (c-met), and its relationship with invasion, metastasis, and prognosis of non-small cell lung cancer ..
  46. ncbi Des-γ-carboxy prothrombin and c-Met were concurrently and extensively expressed in hepatocellular carcinoma and associated with tumor recurrence
    Jianjun Gao
    Hepato Biliary Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Biosci Trends 6:153-9. 2012
    ..Results of the current study suggested that DCP and c-Met are commonly and concurrently expressed in HCC and their absence is associated with a low risk of tumor recurrence...
  47. ncbi Altered down regulation of the receptor tyrosine kinase met in pancreatic adenocarcinoma cells
    Kristen S Hill
    Department of Neuroscience and Cell Biology, Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1074, USA
    J Exp Ther Oncol 8:297-312. 2010
    ..Together our data indicate that uncoupled Met down regulation likely functions to amplify the oncogenic signaling of Met in pancreatic tumor cells...
  48. doi Degradation of the GAB1 adaptor by the ubiquitin-proteasome pathway hampers HGF/SF-MET signaling
    Gautier Goormachtigh
    CNRS UMR, Institut de Biologie de Lille, Universite Lille Nord de France, Institut Pasteur de Lille, France
    Biochem Biophys Res Commun 411:780-5. 2011
    ..These data demonstrate that GAB1 is ubiquitinated by CBL and degraded by the proteasome, and plays a role in negative-feedback regulation of HGF/SF-MET signaling...
  49. doi Inhibition of HGF/cMET expression prevents distant recurrence of rectal cancer after preoperative chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Int J Oncol 40:583-91. 2012
    ....
  50. pmc Replication of the association of a MET variant with autism in a Chinese Han population
    Xue Zhou
    Department of Children s and Adolescent Health, Public Health College of Harbin Medical University, Harbin, Heilongjiang, People s Republic of China
    PLoS ONE 6:e27428. 2011
    ....
  51. ncbi [Study of gastric carcinoma and PCNA and c-met gene abnormality]
    Jing Ji
    School of Public Health, Qingdao University, Qingdao 266021, China
    Wei Sheng Yan Jiu 37:479-82. 2008
    ..To explore the changed regularity of proliferating cell nuclear antigen (PCNA) and c-met gene abnormality in the oncogenic pathway of gastric carcinoma...
  52. doi Demethylation of a LINE-1 antisense promoter in the cMet locus impairs Met signalling through induction of illegitimate transcription
    B Weber
    Division of Epigenetics, DKFZ ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany
    Oncogene 29:5775-84. 2010
    ..Our results thus provide an important paradigm for demethylation-dependent modulation of gene expression, even if the promoter of the corresponding gene is unmethylated...
  53. ncbi Activation of the hepatocyte growth factor (HGF)-Met system in papillary thyroid cancer: biological effects of HGF in thyroid cancer cells depend on Met expression levels
    Rossana Mineo
    Dipartimento di Medicina Sperimentale e Clinica, Policlinico Mater Domini, University of Catanzaro Magna Graecia, Via Tommaso Campanella 115, 88100 Catanzaro, Italy
    Endocrinology 145:4355-65. 2004
    ....
  54. ncbi Differential expression of c-Met, its ligand HGF/SF and HER2/neu in DCIS and adjacent normal breast tissue
    K Lindemann
    Department of Obstetrics and Gynaecology, Technical University, Munich, Germany
    Histopathology 51:54-62. 2007
    ....
  55. pmc Signaling networks assembled by oncogenic EGFR and c-Met
    Ailan Guo
    Cell Signaling Technology Inc, 3 Trask Lane, Danvers, MA 01923, USA
    Proc Natl Acad Sci U S A 105:692-7. 2008
    ..Comparison of the signaling networks in EGFR and c-Met-dependent cells identify a "core network" of approximately 50 proteins that participate in pathways mediating drug response...
  56. pmc MET receptor sequence variants R970C and T992I lack transforming capacity
    Jeffrey W Tyner
    Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Cancer Res 70:6233-7. 2010
    ..Here we present an analysis of two sequence variants of the MET receptor (hepatocyte growth factor receptor) R970C and T992I (also designated R988C and T1010I)...
  57. ncbi Intermediate cells in normal and malignant prostate epithelium express c-MET: implications for prostate cancer invasion
    Geert van Leenders
    Department of Pathology, University Medical Center St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Prostate 51:98-107. 2002
    ..We demonstrate localization of hepatocyte growth factor (HGF) receptor c-MET in intermediate cells in both normal and malignant prostate epithelium...
  58. ncbi Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms
    Donna E Hansel
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Cancer Res 10:6152-8. 2004
    ....
  59. ncbi Immunoblot analysis of c-Met expression in human colorectal cancer: overexpression is associated with advanced stage cancer
    Zhaoshi Zeng
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Exp Metastasis 21:409-17. 2004
    ..C-Met protein is expressed at levels significantly higher than adjacent mucosa in most primary adenocarcinomas of the colon. Our results support an important role for c-Met in human CRC progression and metastasis...
  60. ncbi A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth
    A Rasola
    Department of Biomedical Sciences, Universita degli Studi di Padova, Padova, Italy
    Oncogene 26:1078-87. 2007
    Overexpressed or activated hepatocyte growth factor receptor, encoded by the MET proto-oncogene, was found in the majority of colorectal carcinomas (CRCs), whose stepwise progression to malignancy requires transcriptional activation of ..
  61. ncbi Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1
    E D Fixman
    Molecular Oncology Group, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H3A 1A1
    J Biol Chem 272:20167-72. 1997
    The Tpr-Met oncoprotein consists of the catalytic kinase domain of the hepatocyte growth factor/scatter factor receptor tyrosine kinase (Met) fused downstream from sequences encoded by the tpr gene...
  62. pmc HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death
    A Bardelli
    Institute for Cancer Research I R C C, University of Torino School of Medicine, Italy
    EMBO J 15:6205-12. 1996
    ..The finding of a link between growth factor receptors and the anti-apoptotic machinery fills a gap in the understanding of the molecular events regulating programmed cell death...
  63. ncbi Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival
    Bart Lutterbach
    Cancer Biology and Therapeutics, Department of Molecular Oncology, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA
    Cancer Res 67:2081-8. 2007
    ..These results strongly suggest that Met amplification identifies a subset of NSCLC likely to respond to new molecular therapies targeting Met...
  64. ncbi A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
    C Ponzetto
    Department of Biomedical Sciences and Oncology, University of Torino Medical School, Italy
    Cell 77:261-71. 1994
    ..The same bidentate motif is conserved in the evolutionarily related receptors Sea and Ron, suggesting that in all members of the HGF/SF receptor family, signal transduction is channeled through a multifunctional binding site.
  65. ncbi Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility
    C Ponzetto
    Department of Biomedical Sciences and Human Oncology, Universita di Torino, 10126 Torino, Italy
    J Biol Chem 271:14119-23. 1996
    ..Thus, two Met-mediated biological responses, motility and growth, can be dissociated on the basis of their differential requirement for a direct link with Ras...
  66. pmc Activating mutations for the met tyrosine kinase receptor in human cancer
    M Jeffers
    Advanced BioScience Laboratories Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 94:11445-50. 1997
    ....
  67. ncbi Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1
    Helena L Palka
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Biol Chem 278:5728-35. 2003
    ..breast tumor cell lines MDA-MB-231, T-47D, and T-47D/Met and have identified the hepatocyte growth factor/scatter factor receptor Met, the adapter protein Gab1, and the junctional component p120 catenin as potential substrates...
  68. ncbi Expression of hepatocyte growth factor and c-Met in the anterior horn cells of the spinal cord in the patients with amyotrophic lateral sclerosis (ALS): immunohistochemical studies on sporadic ALS and familial ALS with superoxide dismutase 1 gene mutation
    Shinsuke Kato
    Department of Neuropathology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Nishi cho 36 1, 683 8504, Yonago, Japan
    Acta Neuropathol 106:112-20. 2003
    ..Such sequestration of HGF and c-Met in LBHIs may suggest partial disruption of the HGF-c-Met system, thereby contributing to the acceleration of neuronal degeneration in FALS patients...
  69. ncbi Protein kinase C controls microtubule-based traffic but not proteasomal degradation of c-Met
    Stephanie Kermorgant
    Protein Phosphorylation Laboratory and Light Microscopy Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    J Biol Chem 278:28921-9. 2003
    ..Thus susceptibility to proteasomal degradation is not a consequence of post-endocytic traffic. The data define a PKC-controlled traffic pathway for c-Met that operates independently of its degradative pathway...
  70. ncbi The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness
    Piera Maggiora
    Laboratory of Cancer Genetics of the Institute for Cancer Research and Treatment, University of Torino School of Medicine, SP 142, Km 3 95, 10060 Candiolo Torino, Italy
    Exp Cell Res 288:382-9. 2003
    ..These data suggest that coexpression of the MET and RON receptors confer a selective advantage to ovarian cancer cells and might promote ovarian cancer progression...
  71. ncbi The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway
    Dakun Wang
    Department of Urology, Department of Pathology and Laboratory Medicine, and The James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 280:16393-401. 2005
    ....
  72. pmc Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity
    Annalisa Petrelli
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, 10060 Candiolo, Italy
    Proc Natl Acad Sci U S A 103:5090-5. 2006
    ..c. transplanted into immunodeficient nu/nu mice. This Ab efficiently down-regulates HGF receptor through a molecular mechanism involving a double proteolytic cleavage: (i) cleavage of the extracellular ..
  73. pmc A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of Met
    Cristina Basilico
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Turin Medical School, I 10060 Candiolo, Turin, Italy
    J Biol Chem 283:21267-77. 2008
    ..Although the IPT-HGF-alpha interaction provides binding strength, the Sema-HGF-beta contact confers selective sensitivity to the active form of the ligand...
  74. pmc Met receptor tyrosine kinase degradation is altered in response to the leucine-rich repeat of the Listeria invasion protein internalin B
    Xiu Gao
    Department of Neuroscience and Cell Biology, Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555 1074, USA
    J Biol Chem 284:774-83. 2009
    ..involves binding of the bacterial protein Internalin B to the host receptor tyrosine kinase Met (hepatocyte growth factor receptor). Activation of Met and downstream signaling cascades is critical for Listeria entry...
  75. doi Expression of c-MET, low-molecular-weight cytokeratin, matrix metalloproteinases-1 and -2 in spinal chordoma
    Takahiko Naka
    Faculty of Medicine, Department of Pathology, Magdeburg University, Magdeburg, Germany
    Histopathology 54:607-13. 2009
    ..The aim of this study was to investigate the significance of c-MET expression in spinal chordoma, which affects patients who are 10-20 years older than those with skull base chordoma...
  76. ncbi Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
    D P Bottaro
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892
    Science 251:802-4. 1991
    ..Covalent cross-linking of 125I-labeled ligand to cellular proteins of appropriate size that were recognized by antibodies to c-met directly established the c-met product as the cell-surface receptor for HGF...
  77. ncbi Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor)
    P Longati
    Department of Biomedical Sciences and Oncology, University of Torino Medical School, Italy
    Oncogene 9:49-57. 1994
    ..In stable transfectants expressing the HGF/SF receptor with single substitution of either Tyr1234 or Tyr1235 the response to HGF/SF was impaired...
  78. ncbi Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
    L Schmidt
    Intramural Research Support Program, SAIC Frederick, MD, USA
    Nat Genet 16:68-73. 1997
    ..The results suggest that missense mutations located in the MET proto-oncogene lead to constitutive activation of the MET protein and papillary renal carcinomas...
  79. ncbi Hepatocyte Growth Factor/scatter factor-induces phosphorylation of cortactin in A431 cells in a Src kinase-independent manner
    L Crostella
    Laboratory of Cell Biology, Institute of Hepatology, Department of Medicine, Royal Free and University College London Medical School, London WC1E 6HX, UK
    Oncogene 20:3735-45. 2001
    The Hepatocyte Growth Factor receptor transduces proliferating and scattering signals in epithelial and endothelial cells...
  80. ncbi A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth
    L Trusolino
    IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Torino, Candiolo, Italy
    Cell 107:643-54. 2001
    ..Such findings invoke an unexpected role for alpha6beta4 in cancer invasion as a functional amplifier of biochemical outputs rather than a mechanical adhesive device...
  81. ncbi Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition
    Gautam Maulik
    Department of Medicine, Division of Adult Oncology, Lowe Center for Thoracic Oncology, Binney Street, Boston, MA 02115, USA
    Cytokine Growth Factor Rev 13:41-59. 2002
    ..Finally, c-Met when mutated or over-expressed in malignant cells serves as an important therapeutic target and the most recent data in terms of inhibition of c-Met and downstream signal transduction pathways is summarized...
  82. ncbi The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma
    P W B Derksen
    Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Leukemia 17:764-74. 2003
    ..Taken together, our data indicate that HGF is a potent myeloma growth and survival factor and suggest that the HGF/Met pathway is a potential therapeutic target in MM...
  83. ncbi Role of the MET/HGF receptor in proliferation and invasive behavior of osteosarcoma
    Nadia Coltella
    Laboratory of Cancer Genetics, Institute for Cancer Research and Treatment IRCC, Strada Provinciale 142, Km 3 95, 10060 Candiolo To, Italy
    FASEB J 17:1162-4. 2003
    Signal transduction downstream HGF receptor (MET) activation involves multiple pathways that account for mitogenesis, motility and morphogenesis in a cell type-dependent fashion...
  84. ncbi Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    Selma Pennacchietti
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy
    Cancer Cell 3:347-61. 2003
    ..These data show that hypoxia promotes tumor invasion by sensitizing cells to HGF stimulation, providing a molecular basis to explain Met overexpression in cancer...
  85. pmc Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor
    Ermanno Gherardi
    Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom
    Proc Natl Acad Sci U S A 100:12039-44. 2003
    ..Our studies provide 3D models and a functional map of the MET ectodomain. They have broad implications for structure-function of the MET receptor and the related semaphorin and plexin proteins...
  86. ncbi Overexpression of gastrin and c-met protein involved in human gastric carcinomas and intestinal metaplasia
    Zhuobin Tang
    Beijing Laboratory of Molecular Oncology, Peking University School of Oncology, Beijing, P R China
    Oncol Rep 11:333-9. 2004
    ..These results indicate that gastrin and c-met play a role in the early process during malignant transformation of the gastric mucosa...
  87. ncbi Prostate cancer and the met hepatocyte growth factor receptor
    Beatrice S Knudsen
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98125, USA
    Adv Cancer Res 91:31-67. 2004
    ..On the basis of the commonly observed overexpression of Met in metastatic prostate cancer, HGF/SF-Met-targeted imaging and therapeutic agents can now be applied toward diagnosis and treatment...
  88. ncbi Activation of c-Met (hepatocyte growth factor receptor) in human gastric cancer tissue
    Takao Inoue
    Department of Biological Sciences, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta, Yokohama 226 8501, Japan
    Cancer Sci 95:803-8. 2004
    ..These results indicate that c-Met is actually activated in gastric carcinoma tissue, and may trigger proliferation/anti-apoptotic signals...
  89. ncbi Sema4D induces angiogenesis through Met recruitment by Plexin B1
    Paolo Conrotto
    Division of Molecular Oncology, Department of Oncological Sciences, IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Strada Provinciale 142 10060, Candiolo, Torino, Italy
    Blood 105:4321-9. 2005
    ..In sum, we identify a proangiogenic semaphorin and provide insight about the signaling machinery exploited by Plexin B1 to control angiogenesis...
  90. pmc A genetic variant that disrupts MET transcription is associated with autism
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37203, USA
    Proc Natl Acad Sci U S A 103:16834-9. 2006
    ..These data implicate reduced MET gene expression in autism susceptibility, providing evidence of a previously undescribed pathophysiological basis for this behaviorally and medically complex disorder...
  91. ncbi Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells
    Natsumi Yamamoto
    Graduate School of Science and Technology, Kobe University, Nada, Kobe, Japan
    J Cell Sci 119:4623-33. 2006
    ..These results suggest that the serum-independent growth of 5637 cells involves the transmembrane signaling cascade via EGFR ligand(s) (but not HGF), EGFR, Src and p145(met)...
  92. pmc Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist
    Daniel Kirchhofer
    Department of Protein Engineering, Genentech, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 104:5306-11. 2007
    ..Thus, although serine proteases and HGF have quite distinct functions in proteolysis and Met signal transduction, respectively, they share a similar activation mechanism...
  93. ncbi Specific Grb2-mediated interactions regulate clathrin-dependent endocytosis of the cMet-tyrosine kinase
    Ning Li
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555 1074, USA
    J Biol Chem 282:16764-75. 2007
    ..These results indicate that the ubiquitin ligase activity of Cbl is critical for clathrin-dependent cMet internalization and suggest a role for Grb2 as an intermediary linking Cbl ubiquitin ligase activity to this process...
  94. ncbi ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1
    Jakub M Swiercz
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    J Biol Chem 283:1893-901. 2008
    ..This work identifies a novel mechanism by which plexin-mediated signaling can be regulated and explains how Sema4D can exert different biological activities through the differential association of its receptor with ErbB-2 and Met...
  95. pmc MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    James Bean
    Human Oncology and Pathogenesis Program, Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:20932-7. 2007
    ..Taken together, these data suggest that MET amplification occurs independently of EGFR(T790M) mutations and that MET may be a clinically relevant therapeutic target for some patients with acquired resistance to gefitinib or erlotinib...
  96. pmc Phosphorylation of MUC1 by Met modulates interaction with p53 and MMP1 expression
    Pankaj K Singh
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    J Biol Chem 283:26985-95. 2008
    ..This correlated with a decrease in hepatocyte growth factor-induced invasiveness when MUC1 was overexpressed. The results demonstrate that MUC1 modulates Met-mediated oncogenic signaling in cancer...
  97. doi MicroRNAs impair MET-mediated invasive growth
    Cristina Migliore
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Torino, Italy
    Cancer Res 68:10128-36. 2008
    ..In conclusion, we have identified miRNAs that behave as oncosuppressors by negatively targeting MET and might thus provide an additional option to inhibit this oncogene in tumors displaying its deregulation...
  98. doi Phosphorylation of the MET receptor on juxtamembrane tyrosine residue 1001 inhibits its caspase-dependent cleavage
    Julien Deheuninck
    CNRS UMR 8161, Institut de Biologie de Lille, Universite Lille Nord de France, Institut Pasteur de Lille, IFR142, Lille, France
    Cell Signal 21:1455-63. 2009
    ..These data demonstrate a direct protection mechanism of an activated phosphorylated MET receptor, against its caspase-dependent cleavage...
  99. pmc HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer
    Lynn M Knowles
    Departments of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 15:3740-50. 2009
    ....
  100. pmc Hepatocyte growth factor and myopia: genetic association analyses in a Caucasian population
    Tammy Yanovitch
    Duke University Center for Human Genetics, 595 La Salle Street, Durham, NC 27710, USA
    Mol Vis 15:1028-35. 2009
    Hepatocyte growth factor (HGF) and hepatocyte growth factor receptor (C-MET) genes have previously been reported to be associated with myopia in Asian family-based and case-control association studies, respectively...
  101. pmc Ethnic differences and functional analysis of MET mutations in lung cancer
    Soundararajan Krishnaswamy
    Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Clin Cancer Res 15:5714-23. 2009
    ....

Research Grants37

  1. Trophokine for regenerative medicine
    Jianmin Fang; Fiscal Year: 2010
    ..This chimeric HGF-MSP protein can bind to HGF receptor c-Met and MSP receptor Ron independently and elicit a biological signal only through Met-Ron heterodimerization...
  2. HGF/HGFR Axis and Fatty Liver Disease
    Reza Zarnegar; Fiscal Year: 2013
    ..data indicate that, in hepatocytes, the insulin receptor (IR) tyrosine kinase crosstalks with the Hepatocyte Growth Factor Receptor (HGFR) tyrosine kinase (also known as Met) through intermolecular tyrosine phosphorylation...
  3. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2010
    ..BB3 activates the SF/HGF receptor, c-Met, and has recapitulated the bioactivity of HGF in every assay tested thus far...
  4. Novel Small Molecules For Acute Liver Failure
    Prakash Narayan; Fiscal Year: 2009
    ..Based on the 3-dimensional structure of the ATP-binding site of the SF/HGF receptor c-Met's tyrosine kinase domain and using a product discovery engine combining rational drug design with ..
  5. SOMATIC CELL TRANSFER TO MODEL MEDULLOBLASTOMA IN MICE
    DANIEL WEBSTER FULTS; Fiscal Year: 2013
    ..MB growth suppression by HGF monoclonal antibody therapy can be enhanced by pharmacologic inhibition of the HGF receptor c- Met or downstream PI3K signaling...
  6. HGF Signaling in Kidney Repair
    Lloyd G Cantley; Fiscal Year: 2012
    ..We have now generated mice with conditional knock-out of the Hgf receptor in either the proximal tubule or collecting duct...
  7. Safety and efficacy of optimized AAV3 vectors in murine and NHP livers
    Arun Srivastava; Fiscal Year: 2013
    ..AAV3 vectors also transduce primary human hepatocytes efficiently, as they utilize human hepatocyte growth factor receptor (HGFR) as a cellular co-receptor...
  8. Reza Zarnegar; Fiscal Year: 2015
    ..The Hepatocyte Growth Factor Receptor (HGFR) known as Met is a transmembrane receptor tyrosine kinase (RTK) that plays an important role ..
  9. Mechanism of Host Cell Invasion by Microbial Pathogens
    Partho Ghosh; Fiscal Year: 2010
    ..InIB acts by binding and activating the host cell receptor tyrosine kinase Met (also called hepatocyte growth factor receptor, HGFR), thereby inducing signaling pathways that lead to actin-dependent uptake of the bacterium...
  10. Anti-Fibrotic Therapy for Pulmonary Fibrosis
    Latha Paka; Fiscal Year: 2007
    ..In vitro, our lead HGF mimetic, Ang1170, activates the HGF receptor, c-Met, and induces its biological functions including activation of endothelial and bronchial epithelial cell ..
  11. Small Molecule Therapeutics for Renal Disease
    Prakash Narayan; Fiscal Year: 2010
    ..has identified BB3, an orally bioavailable small molecule SF/HGF mimetic. BB3 activates the SF/HGF receptor c-Met and recapitulates the bioactivities of SF/HGF in every assay tested to date...
  12. LIVER REGENERATION AND GROWTH FACTORS
    SANDRA DEGEN; Fiscal Year: 2000
    ..These studies will determine the diversity of the biological properties of HGF-like protein and whether it is a growth factor with limited or broad specificity. ..
  13. HGF receptor and renal cell survival and differentiation
    Youhua Liu; Fiscal Year: 2006
    ..Ultimately, these studies may lead to development of novel strategies to alter the course of human renal disease by manipulating the activities of HGF/c-met signaling system. ..
  14. Regulating HGF Receptor Internalization
    LISA ELFERINK; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): The importance of Hepatocyte Growth Factor Receptor signaling in normal and pathological conditions is well established...
  15. HGF RECEPTOR GENE REGULATION AND RENAL GROWTH
    Youhua Liu; Fiscal Year: 2003
    ..Ultimately, these studies may suggest novel strategies to alter the course of human renal disease by regulating the HGF/c-met axis. ..
  16. Therapeutic Potential of Refanalin in Pulmonary Fibrosis
    Latha Paka; Fiscal Year: 2004
    ..In vitro, our lead HGF mimetic, Refanalin, activates the HGF receptor, c-Met, and induces its biological functions including activation of endothelial and bronchial epithelial cell ..
  17. Role of TFE3 in Renal Cell Carcinoma
    Christopher Roman; Fiscal Year: 2004
    ..Our studies will enhance our understanding of how TFE3 mutation promotes transformation of renal cells, and provide insight into new interventive strategies for PRCC. ..
  18. Small Molecule Therapeutics for Renal Disease
    Prakash Narayan; Fiscal Year: 2007
    ..has identified two, chemically distinct, small molecules that activate the SF/HGF receptor c-Met...
  19. Protection from Stroke by SF/HGF-like Small Molecule
    Prakash Narayan; Fiscal Year: 2004
    ..identified a small molecule, Refanalin that recapitulates the biologic activity of SF/HGF by activating the SF/HGF receptor, c-met...
  20. Renal Injury Prevention by SF/HGF-like Small Molecules
    Prakash Narayan; Fiscal Year: 2004
    ..C6 recapitulates many of the bioactivities of SF/HGF, both in vitro and in vivo, by activation of the SF/HGF receptor, c-met...
  21. AGE AND MICROENVIRONMENT EFFECT ON PROSTATE CANCER
    Gary Smith; Fiscal Year: 2002
    ..factor family, TGF-beta family, and HGF and of their cognate receptors on the epithelial membrane, including HGF receptor c-met and the mannose-6-phosphate/IGF ll receptor which binds both TGF-beta1 and IGF-ll...
  22. Protection from Atherosclerosis by c-Met Agonist
    Latha Paka; Fiscal Year: 2003
    ..In vitro, C6 activates SF/HGF receptor, c-met to mediate biological functions of SF/HGF, such as renal cell scatter, endothelial cell proliferation, ..
  23. Novel Small Molecule Therapeutic for Spinal Cord Injury
    Alexander Yuzhakov; Fiscal Year: 2006
    ..Preliminary data indicates that Rf recapitulates the biologic activity of HGF/SF in vitro by activating the HGF/SF receptor, Met resulting in impressive pro-proliferative, scattering and anti-apoptotic effects in Schwann cells...
  24. Studies of a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC)
    Ravi Salgia; Fiscal Year: 2011
    ..Conduct an anti-c-Met phase I/I I clinical trial against NSCLC. Through the achievement of the goals proposed in these specific aims, we will arrive at novel therapy against c- Met in lung cancer. ..
  25. Molecular Basis of Young Onset Colorectal Cancer
    Lisa Boardman; Fiscal Year: 2006
    ..Following achievement of these goals, I am confident that I will be ready to continue my career as a successful independent investigator committed to colerectal cancer prevention and control. ..
  26. HGF Signaling in Pulmonary Remodeling
    Regina Day; Fiscal Year: 2007
    ..In addition, it is expected that the results will fundamentally advance the field of lung cell biology. ..
  27. Examination of activating Met mutations in tumorigenesis
    Carrie Graveel; Fiscal Year: 2007
    ..abstract_text> ..
  28. Glycosynapses in cancer cell adhesion and signaling
    Sen itiroh Hakomori; Fiscal Year: 2009
    ....
  29. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  30. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
    ..abstract_text> ..
  31. Carbohydrate-carbohydrate interaction in basic cell biology
    Sen itiroh Hakomori; Fiscal Year: 2006
    ..abstract_text> ..
  32. Molec. Profiling of Oral Cancer Aggressiveness/Outcome
    Barry Ziober; Fiscal Year: 2005
    ..The unique molecular signature for OSCC tumor aggressiveness and the predictor of patient outcome established from this work has the enormous potential to reduce OSCC patient mortality and morbidity. ..
  33. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  34. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  35. SPHINGOSINE DEPENDENT KINASE AND CARCINOGENESIS
    Senitiroh Hakomori; Fiscal Year: 2003
    ..In the inhibitory effect is confirmed, its mechanism will be studied in relation to activities of SDKs, MAPK, bcl-2, and other signal transducers. ..
  36. PLASMALOPSYCHOSINE AS NEUROTROPHIC FACTOR
    Senitiroh Hakomori; Fiscal Year: 2003
    ..Results of these studies may provide a basis for development of PLPS and its analogues as therapeutic reagents for neurodegenerative diseases and neuronal injury. ..
  37. GENETIC STUDIES OF LYMPHEDEMA
    David Finegold; Fiscal Year: 2002
    ..abstract_text> ..