BY55

Summary

Gene Symbol: BY55
Description: CD160 molecule
Alias: BY55, NK1, NK28, CD160 antigen, CD160 transmembrane isoform, CD160-delta Ig, natural killer cell receptor BY55, natural killer cell receptor, immunoglobulin superfamily member
Species: human

Top Publications

  1. pmc Electrophysiological evidence for different release mechanism of ATP and NO as inhibitory NANC transmitters in guinea-pig colon
    V Zagorodnyuk
    Department of Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Br J Pharmacol 112:1077-82. 1994
  2. ncbi Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes
    A Anumanthan
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 161:2780-90. 1998
  3. ncbi Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells
    S Agrawal
    Institut National de la Santé et de la Recherche Médicale U448, Henri Mondor Hospital, Faculte de Medecine, Creteil, France
    J Immunol 162:1223-6. 1999
  4. ncbi BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression
    Maria Nikolova
    INSERM 448, Faculté de Médecine de Créteil, 8 rue du General Sarrail, 94010, France
    Int Immunol 14:445-51. 2002
  5. ncbi Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset
    Aliz Barakonyi
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 563, Centre de Physiopathologie Toulouse Purpan, Toulouse, France
    J Immunol 173:5349-54. 2004
  6. ncbi Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation
    Sofia Abecassis
    INSERM Unit 659, Creteil, France
    J Invest Dermatol 127:1161-6. 2007
  7. ncbi A soluble form of the MHC class I-specific CD160 receptor is released from human activated NK lymphocytes and inhibits cell-mediated cytotoxicity
    Jerome Giustiniani
    Institut National de la Santé et de la Recherche Médicale 659, University Paris XII, Faculté de Médecine de Créteil, 94000 Creteil, France
    J Immunol 178:1293-300. 2007
  8. pmc Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation
    Jerome Giustiniani
    Institeut National de la Santé et de la Recherche Médicale Unite 841, Department of Immunology, Universite Paris 12, Faculté de Médecine de Créteil, Creteil, France
    J Immunol 182:63-71. 2009
  9. pmc CD160 signaling mediates PI3K-dependent survival and growth signals in chronic lymphocytic leukemia
    Feng Ting Liu
    Academic Haematology Unit, Blizard Institute of Cell and Molecular Science, Queen Mary University of London, London, United Kingdom
    Blood 115:3079-88. 2010
  10. pmc A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor
    Sophie Chabot
    Institut National de la Santé et de la Recherche Médicale U1043, F 31300 Toulouse, France
    J Exp Med 208:973-86. 2011

Research Grants

  1. Anti-HIV Neuroimmunomodulatory Therapy with Neurokinin-1 (NK1-R) Antagonists
    STEVEN DANIEL DOUGLAS; Fiscal Year: 2013
  2. Kerry J Ressler; Fiscal Year: 2014
  3. Nanoparticle mediated in vivo cell-type specific drug delivery for pain relief
    Zhigang David Luo; Fiscal Year: 2013
  4. PHYSIOLOGICAL CORRELATES OF NEURAL PLASTICITY
    LILLIAN PUBOLS; Fiscal Year: 1993
  5. Nancy J Brown; Fiscal Year: 2014
  6. NEUROPEPTIDERGIC INHIBITION OF SPINAL PAIN TRANSMISSION
    Bradley K Taylor; Fiscal Year: 2013
  7. Neuronal Changes in Adult Rats Induced by Neonatal Pain
    Adrian Miranda; Fiscal Year: 2011
  8. Barbara J Mason; Fiscal Year: 2015
  9. Tony L Yaksh; Fiscal Year: 2014
  10. Victor J Hruby; Fiscal Year: 2015

Detail Information

Publications258 found, 100 shown here

  1. pmc Electrophysiological evidence for different release mechanism of ATP and NO as inhibitory NANC transmitters in guinea-pig colon
    V Zagorodnyuk
    Department of Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Br J Pharmacol 112:1077-82. 1994
    ..3 microM), the addition of the NK1 receptor antagonist, SR 140,333 (1 microM) abolished the non-adrenergic, non-cholinergic (NANC) excitatory junction ..
  2. ncbi Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes
    A Anumanthan
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 161:2780-90. 1998
    Expression of the BY55 protein has been shown to be tightly associated with NK and CD8+ T lymphocytes with cytolytic effector activity. To determine the function of this protein, we molecularly cloned BY55 cDNA...
  3. ncbi Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells
    S Agrawal
    Institut National de la Santé et de la Recherche Médicale U448, Henri Mondor Hospital, Faculte de Medecine, Creteil, France
    J Immunol 162:1223-6. 1999
    b>BY55 is a human cell surface molecule whose expression is restricted to NK cells, a subset of circulating CD8+ T lymphocytes, and all intestinal intraepithelial T lymphocytes...
  4. ncbi BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression
    Maria Nikolova
    INSERM 448, Faculté de Médecine de Créteil, 8 rue du General Sarrail, 94010, France
    Int Immunol 14:445-51. 2002
    ..we examined the role of the recently identified glycosylphosphatidylinositol (GPI)-anchored cell surface molecule BY55, assigned as CD160, in TCR signaling...
  5. ncbi Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset
    Aliz Barakonyi
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 563, Centre de Physiopathologie Toulouse Purpan, Toulouse, France
    J Immunol 173:5349-54. 2004
    ..Thus, the CD160 receptor represents a unique triggering surface molecule expressed by cytotoxic NK cells that participates in the inflammatory response and determines the type of subsequent specific immunity...
  6. ncbi Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation
    Sofia Abecassis
    INSERM Unit 659, Creteil, France
    J Invest Dermatol 127:1161-6. 2007
    ..Thus, we hypothesize that the unique CD4+ CD160+ lymphocyte subset plays a role in the pathogenesis of skin inflammation...
  7. ncbi A soluble form of the MHC class I-specific CD160 receptor is released from human activated NK lymphocytes and inhibits cell-mediated cytotoxicity
    Jerome Giustiniani
    Institut National de la Santé et de la Recherche Médicale 659, University Paris XII, Faculté de Médecine de Créteil, 94000 Creteil, France
    J Immunol 178:1293-300. 2007
    ..Thus, we show that activated NK lymphocytes release a soluble form of CD160 that functionally impairs the MHC-I-specific cytotoxic CD8(+) T lymphocyte responsiveness...
  8. pmc Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation
    Jerome Giustiniani
    Institeut National de la Santé et de la Recherche Médicale Unite 841, Department of Immunology, Universite Paris 12, Faculté de Médecine de Créteil, Creteil, France
    J Immunol 182:63-71. 2009
    ..mRNAs generated through alternative splicings of the CD160 gene, among which one encoded a putative CD160 transmembrane isoform (CD160-TM)...
  9. pmc CD160 signaling mediates PI3K-dependent survival and growth signals in chronic lymphocytic leukemia
    Feng Ting Liu
    Academic Haematology Unit, Blizard Institute of Cell and Molecular Science, Queen Mary University of London, London, United Kingdom
    Blood 115:3079-88. 2010
    ..Thus, in vitro, CLL cells can use the CD160 pathway for survival and activation, mimicking CD160 signaling in normal NK and CD8(+) T cells. Establishing the pathophysiologic relevance of these findings may reveal new therapeutic targets...
  10. pmc A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor
    Sophie Chabot
    Institut National de la Santé et de la Recherche Médicale U1043, F 31300 Toulouse, France
    J Exp Med 208:973-86. 2011
    ..These studies validate CD160 as a potential new target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs...
  11. pmc Differential and tumor-specific expression of CD160 in B-cell malignancies
    Timothy W Farren
    Division of Haemato Oncology and Immunophenotyping Section, Department of Haematology, Barts and The London National Health Service NHS Trust, London, UK
    Blood 118:2174-83. 2011
    ..In the B-cell lineage, CD160 is a tumor-specific antigen known to mediate cellular activation signals in CLL, and is a novel target for therapeutic manipulation and monitoring of minimal residual disease...
  12. doi Molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor CD160 and its relationship to the cosignaling molecules BTLA and LIGHT
    Rieko Kojima
    Laboratory of Biomolecular Science, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    J Mol Biol 413:762-72. 2011
    ..These results provide insight into the molecular architecture of the CD160/BTLA/LIGHT/HVEM signaling complex that regulates immune function...
  13. pmc CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction
    Yoav Peretz
    Caprion ImmuneCarta Services, Montreal, Quebec, Canada
    PLoS Pathog 8:e1002840. 2012
    ....
  14. doi CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator
    Guifang Cai
    Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 9:176-85. 2008
    ..CD160 thus serves as a negative regulator of CD4+ T cell activation through its interaction with HVEM...
  15. pmc Mechanism of bradykinin-induced plasma extravasation in the rat knee joint
    H Cambridge
    Pharmacology Group, King s College London
    Br J Pharmacol 115:641-7. 1995
    ..5. The selective neurokinin1 (NK1) receptor antagonist, RP67580 (230 nmol kg-1), or receptor antagonists for the mast cell products histamine and 5-..
  16. pmc Inhibition of nitric oxide synthesis reveals non-cholinergic excitatory neurotransmission in the canine proximal colon
    C W Shuttleworth
    Department of Physiology, University of Nevada School of Medicine, Reno 89557
    Br J Pharmacol 109:739-47. 1993
    ..contractions to EFS were enhanced by indomethacin (10 microM) and reduced or abolished by the non-selective NK1/NK2 tachykinin receptor antagonist D-Pro2, D-Trp7,9 SP, and by the selective NK2 receptor antagonist MEN 10,376 (10 ..
  17. pmc An investigation into the mechanism of capsaicin-induced oedema in rabbit skin
    P Newbold
    Pharmacology Group, King s College, London
    Br J Pharmacol 114:570-7. 1995
    ..However, oedema was not inhibited when capsaicin was co-injected with the neurokinin NK1 receptor antagonist, RP67580 (10 nmol), the NK2 antagonist SR48960 (10 nmol) or the CGRP antagonist CGRP8-37 (300 ..
  18. pmc Characterization of the capsaicin-sensitive component of cyclophosphamide-induced inflammation in the rat urinary bladder
    A Ahluwalia
    Department of Biochemical Pharmacology, William Harvey Research Institute, Medical College of St Bartholomew s Hospital, London, England
    Br J Pharmacol 111:1017-22. 1994
    ..3. Intraperitoneal (i.p.) pretreatment with the tachykinin NK1 receptor antagonist, RP 67,580 (0.44 mg kg-1) or the bradykinin B2 receptor antagonist, Hoe 140 (0...
  19. pmc Depression of primary afferent-evoked responses by GR71251 in the isolated spinal cord of the neonatal rat
    J Z Guo
    Department of Pharmacology, Faculty of Medicine, Tokyo Medical University, Japan
    Br J Pharmacol 110:1142-8. 1993
    ..The NK1 agonist, acetyl-Arg6-septide, and the NK3 agonist, senktide, at 0...
  20. pmc Role of kinins in anaphylactic-induced bronchoconstriction mediated by tachykinins in guinea-pigs
    F L Ricciardolo
    Cardiovascular Research Institute, University of California San Francisco
    Br J Pharmacol 113:508-12. 1994
    ..On the other hand, a combination of the NK1 (CP-96,345, 2 mumol kg-1, i.v.) and NK2 (SR 48968, 0.3 mumol kg-1, i.v...
  21. pmc The influence of the trigeminal ganglion on carotid blood flow in anaesthetized guinea-pigs
    D T Beattie
    Pharmacology II, Glaxo Research and Development Ltd, Ware, Herts
    Br J Pharmacol 112:262-6. 1994
    ..evoked by trigeminal ganglion stimulation were, however, unaffected by intravenous injection of the tachykinin NK1 receptor antagonists, GR82334 (0.3 mg kg-1) and CP-99,994 (0...
  22. pmc Characterization of the receptor and the mechanisms underlying the inflammatory response induced by des-Arg9-BK in mouse pleurisy
    R M Vianna
    Department of Pharmacology, Centre of Biological Sciences, Universidade Federal de Santa Catarina, , Brazil
    Br J Pharmacol 123:281-91. 1998
    ..4 An i.t. injection of the selective tachykinin receptor antagonists (NK1) FK 888 (1 nmol per site), (NK2) SR 48968 (20 nmol per site) or (NK3) SR 142801 (10 nmol per site), administered 5 ..
  23. pmc Mechanisms of bradykinin-induced contraction of the guinea-pig gallbladder in vitro
    D A Cabrini
    Universidade Federal de Santa Catarina, , Brazil
    Br J Pharmacol 114:1549-56. 1995
    ..1 microM, a selective leukotriene D4 receptor antagonist), tetrodotoxin(0.3microM), CP 96,345 (0.3 microM, a NK1 receptor antagonist), mepyramine (1 microM), glibenclamide (1 microM), H-7(3 microM), staurosporine (100 nM), or ..
  24. pmc The role of tachykinin NK1 and NK2 receptors in atropine-resistant colonic propulsion in anaesthetized guinea-pigs
    A Lecci
    Pharmacology Research Department, Menarini Ricerche S p A, Florence, Italy
    Br J Pharmacol 124:27-34. 1998
    ..endogenous tachykinins on guinea-pig colonic propulsion was investigated by using potent and selective tachykinin NK1 and NK2 receptor antagonists...
  25. pmc Modulatory effect of neuropeptide Y on acetylcholine-induced oedema and vasoconstriction in isolated perfused lungs of rabbit
    A Delaunois
    Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, , Belgium
    Br J Pharmacol 113:973-81. 1994
    ..and aspirin, an inhibitor of cyclo-oxygenase, while ketanserin, a 5-HT2 receptor antagonist, and SR140333, a new NK1 antagonist, had no protective effect...
  26. pmc Postjunctional inhibitory effect of the NK2 receptor antagonist, SR 48968, on sensory NANC bronchoconstriction in the guinea-pig
    Y P Lou
    Department of Pharmacology, Karolinska Institute, Stockholm, Sweden
    Br J Pharmacol 109:765-73. 1993
    ..The selective NK1 receptor antagonist, CP 96,345 (10(-6) M), together with SR 48968 completely abolished the remaining EFS-evoked ..
  27. pmc Modulation of excitatory amino acid responses by tachykinins and selective tachykinin receptor agonists in the rat spinal cord
    M J Cumberbatch
    Department of Physiology, University of Bristol, School of Medical Sciences
    Br J Pharmacol 115:1005-12. 1995
    ..2. The NK1-selective agonist, GR 73632, enhanced responses to all three EAAs similarly, whilst the NK2-selective agonist, ..
  28. pmc Endogenous tachykinins facilitate transmission through parasympathetic ganglia in guinea-pig trachea
    N Watson
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 109:751-9. 1993
    ..effect of tachykinins has also been examined, by the use of selective tachykinin receptor agonists and a selective NK1 receptor antagonist. 2...
  29. pmc Pharmacological characterization of the contractile responses to angiotensin analogues in guinea-pig isolated longitudinal muscle of small intestine
    A B Hawcock
    Neuropharmacology Department, Glaxo Group Research Ltd, Ware, Hertfordshire
    Br J Pharmacol 108:1150-5. 1993
    ..Furthermore, while responses to these agonists were not significantly modified by the NK1 receptor antagonist (+/-)-CP-96,345 (30 nM) alone, the combined pre-incubation with both atropine and (+/-)-CP-96,..
  30. pmc Pharmacological analysis of the local and reflex responses to bradykinin on rat urinary bladder motility in vivo
    A Lecci
    Pharmacology Research Dept, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 114:708-14. 1995
    ..3. Intrathecal administration of the tachykinin NK1 receptor antagonists, RP 67,580 (10 nmol/rat) or SR 140,333 (10 nmol/rat), abolished the chemoceptive reflex ..
  31. pmc Evidence for a capsaicin-sensitive, tachykinin-mediated, component in the NANC contraction of the rat urinary bladder to nerve stimulation
    S Meini
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 112:1123-31. 1994
    ..4. The tachykinin NK1 receptor antagonist, SR 140,333 (0...
  32. pmc Calcitonin gene-related peptide (CGRP)-enhanced non-adrenergic non-cholinergic contraction of guinea-pig proximal colon
    S Kojima
    Department of Pharmacology, Dokkyo University School of Medicine, Tochigi, Japan
    Br J Pharmacol 115:1290-4. 1995
    ..3 microM), to block tachykinin NK1 and NK2 receptors, respectively. Thus, the EFS-induced NANC contractions are a tachykinin-mediated response. 3...
  33. pmc Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo
    Y Hirayama
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 108:844-51. 1993
    1. We compared the effects of two novel tachykinin receptor antagonists, FK888 (selective at the tachykinin NK1 receptor) and FK224 (dual antagonist at NK1 and NK2 tachykinin receptors) on stimulus-evoked airway plasma exudation, ..
  34. pmc Tachykinin receptors in the guinea-pig renal pelvis: activation by exogenous and endogenous tachykinins
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 107:27-33. 1992
    1. The contractile response to substance P, neurokinin A, selective agonists for the NK1, NK2 and NK3 tachykinin receptors and the activity of receptor-selective antagonists has been investigated in circular muscle strips of the guinea-..
  35. pmc Effects of interactions of naturally-occurring neuropeptides on blood flow in the rat knee joint
    F Y Lam
    Institute of Physiology, University of Glasgow
    Br J Pharmacol 108:694-9. 1993
    ..5. Co-administration of 1 nmol of the specific NK1 receptor antagonist, CP-96345, with 1 nmol of each of the neurokinins produced significant inhibition of the ..
  36. pmc In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists
    A D Medhurst
    Department of Neurosciences Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex
    Br J Pharmacol 122:469-76. 1997
    ..2 Hz) or substance P, exemplifying the selectivity of this class of antagonist for functional NK3 receptors over NK1 receptors in the rabbit. 6. In vivo, senktide (1, 10 and 25 microg i.v., i.e. 1.2, 11.9 and 29...
  37. pmc Evidence that tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitation and contraction in the circular muscle of guinea-pig duodenum
    V Zagorodnyuk
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 115:237-46. 1995
    ..2. The selective tachykinin (TK) NK1 receptor antagonist, GR 82,334 (30 nM-3 microM) produced a concentration-dependent inhibition of the EFS-evoked ..
  38. pmc Role of intrathecal tachykinins for micturition in unanaesthetized rats with and without bladder outlet obstruction
    O Ishizuka
    Department of Urology, Lund University Hospital, Sweden
    Br J Pharmacol 113:111-6. 1994
    1. The effects on micturition of RP 67,580, a selective NK1 receptor antagonist, and SR 48,968, a highly, potent antagonist at NK2 receptor sites, given intrathecally (i.t.) or intra-arterially (i.a...
  39. pmc The interaction of the NK1 receptor antagonist CP-96,345 with L-type calcium channels and its functional consequences
    S Guard
    Parke Davis Neuroscience Research Centre, Addenbrookes Hospital Site, Cambridge
    Br J Pharmacol 110:385-91. 1993
    1. We investigated the effects of the non-peptide NK1 receptor antagonist, CP-96,345, its inactive enantiomer CP-96,344, and the racemic mixture (+/-)-CP-96,345, on the binding of [3H]-nimodipine and [3H]-diltiazem to L-type calcium ..
  40. pmc Cardiovascular and behavioural effects of centrally administered tachykinins in the rat: characterization of receptors with selective antagonists
    P Picard
    Department of Physiology, Faculty of Medicine, , , Canada
    Br J Pharmacol 112:240-9. 1994
    1. The effects of intracerebroventricular (i.c.v.) injection of selective and potent NK1 (RP 67580), NK2 (SR 48968) and NK3 (R 486, [Trp7, beta-Ala8]NKA(4-10)) receptor antagonists were assessed on the cardiovascular and behavioural ..
  41. ncbi Specialization of tachykinin NK1 and NK2 receptors in producing fast and slow atropine-resistant neurotransmission to the circular muscle of the guinea-pig colon
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Neuroscience 63:1137-52. 1994
    We studied the relative contribution of tachykinin NK1 and NK2 receptors in producing nonadrenergic noncholinergic excitation of the circular muscle of the guinea-pig proximal colon in response to electrical field stimulation...
  42. ncbi [Mechanism of action of antidepressant drugs: importance of genetically modified mice in the pharmacological in vivo approach]
    Alain Gardier
    Laboratoire de Neuropharmacologie EA3544, Faculte de Pharmacie, Universite Paris Sud, Chatenay Malabry, France
    Therapie 60:469-76. 2005
    ..The study of substance P (neurokinin 1 receptor [R-NK1]) offers another example of the use of KO mice in the development of a new class of antidepressant drugs...
  43. pmc Identification of both NK1 and NK2 receptors in guinea-pig airways
    K T McKee
    Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, Pointe Claire, Dorval, , Canada
    Br J Pharmacol 110:693-700. 1993
    1. NK1 and NK2 receptors have been characterized in guinea-pig lung membrane preparations by use of [125I-Tyr8]-substance P and [125I]-neurokinin A binding assays in conjunction with tachykinin-receptor selective agonists ([Sar9Met(O2)11]..
  44. pmc Delayed-type hypersensitivity-induced increase in vascular permeability in the mouse small intestine: inhibition by depletion of sensory neuropeptides and NK1 receptor blockade
    A D Kraneveld
    Department of Pharmacology, Utrecht University, The Netherlands
    Br J Pharmacol 114:1483-9. 1995
    1. This study investigates the effects of capsaicin-induced depletion of sensory neuropeptides and of neurokinin1 (NK1) receptor blockade on delayed-type hypersensitivity (DTH)-induced changes of vascular permeability in the small ..
  45. pmc Comparison of tachykinin NK1 and NK2 receptors in the circular muscle of the guinea-pig ileum and proximal colon
    C A Maggi
    Pharmacology and Chemistry Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 112:150-60. 1994
    1. The aim of this study was the pharmacological characterization of tachykinin NK1 and NK2 receptors mediating contraction in the circular muscle of the guinea-pig ileum and proximal colon...
  46. pmc Tachykinin NK1 and NK2 receptor antagonists and atropine-resistant ascending excitatory reflex to the circular muscle of the guinea-pig ileum
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 112:161-8. 1994
    1. The aim of this study was to investigate the effect of various antagonists, selective for the tachykinin NK1 or NK2 receptor, on the atropine-resistant ascending excitatory reflex (AER) to the circular muscle of the guinea-pig ileum ..
  47. pmc Tachykininergic transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of NK2 receptors
    L Bartho
    Department of Pharmacology, University Medical School of Pecs, Hungary
    Br J Pharmacol 105:805-10. 1992
    1. The effect of newly developed, receptor-selective tachykinin antagonists (GR 71,251 for NK1 receptors, MEN 10,376 and L 659,877 for NK2 receptors) on noncholinergic transmission to the circular muscle of the guinea-pig ileum has been ..
  48. pmc Differences in the distribution and characteristics of tachykinin NK1 binding sites between human and guinea pig lung
    D A Walsh
    Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London
    Br J Pharmacol 113:1407-15. 1994
    1. The distribution and characteristics of tachykinin NK1 binding sites have been compared in human and guinea pig lung using quantitative in vitro receptor autoradiography with [125I]-Bolton Hunter-labelled substance P ([125I]-BH-SP)...
  49. pmc Tachykinin NK1 receptor in the guinea-pig isolated proximal urethra: characterization by receptor selective agonists and antagonists
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 106:888-92. 1992
    ..Substance P (EC50 155 nM) was slightly (3.6 times) more potent than neurokinin A (EC50 560 nM). 3. The tachykinin NK1 receptor selective agonist, [Sar9]substance P sulphone (EC50 62 nM), was slightly more potent than substance P and ..
  50. pmc Typical and atypical NK1 tachykinin receptor characteristics in the rabbit isolated iris sphincter
    J M Hall
    Biomedical Sciences Division, King s College London, Chelsea
    Br J Pharmacol 112:985-91. 1994
    1. A contraction of the rabbit isolated iris sphincter smooth muscle follows activation of either tachykinin NK1 or NK3 receptors...
  51. pmc Effect of the tachykinin NK1 receptor antagonists, RP 67580 and SR 140333, on electrically-evoked substance P release from rat spinal cord
    M Malcangio
    Department of Pharmacology, School of Pharmacy, London
    Br J Pharmacol 113:635-41. 1994
    1. The effects of the non-peptide tachykinin NK1 receptor antagonists, RP 67580, SR 140333, CP-96,345 and CP-99,994 have been investigated on electrically-evoked release of substance P-like immunoreactivity (SP-LI) from rat spinal cord ..
  52. pmc Effects of RP 67580, a tachykinin NK1 receptor antagonist, on a primary afferent-evoked response of ventral roots in the neonatal rat spinal cord
    R Hosoki
    Department of Pharmacology, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    Br J Pharmacol 113:1141-6. 1994
    1. The pharmacological characteristics of RP 67580, a non-peptide tachykinin NK1 receptor antagonist, and its effects on a reflex response evoked by stimulation of primary afferent fibres, were examined in isolated neonatal spinal cord ..
  53. ncbi Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice
    Peter G E Kennedy
    Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, UK
    Brain 126:1683-90. 2003
    ..We investigated the effect of disrupting the gene encoding for the NK1 receptor in mice on the clinical and neuroinflammatory response in this model...
  54. pmc Tachykinin receptors in rabbit airways--characterization by functional, autoradiographic and binding studies
    J L Black
    Department of Pharmacology, University of Sydney, NSW, Australia
    Br J Pharmacol 107:429-36. 1992
    1. In many species, both NK1 and NK2 tachykinin receptors appear to be important in mediating the contraction of airway smooth muscle...
  55. pmc Subtypes of tachykinin receptors on tonic and phasic neurones in coeliac ganglion of the guinea-pig
    F Y Zhao
    Department of Pharmacology, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    Br J Pharmacol 115:25-30. 1995
    ..5. GR71251 (5 microM), an NK1-selective tachykinin receptor antagonist, depressed the depolarization in tonic neurones and the LAH inhibition in ..
  56. pmc Tachykinin NK1 but not NK2 receptors mediate non-cholinergic excitatory junction potentials in the circular muscle of guinea-pig colon
    V Zagorodnyuk
    Department Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Br J Pharmacol 110:795-803. 1993
    1. The effect of tachykinin NK1 and NK2 receptor antagonists on noncholinergic excitatory junction potentials (e.j...
  57. pmc Cardiovascular and behavioural effects of intracerebroventricularly administered tachykinin NK3 receptor antagonists in the conscious rat
    E Cellier
    Department of Physiology, Faculty of Medicine, , , Canada
    Br J Pharmacol 122:643-54. 1997
    ..to affect the central cardiovascular and behavioural responses induced by 10 pmol [Sar9, Met(O2)11]substance P, a NK1 receptor selective agonist. The senktide-induced behavioural changes were not inhibited by R820 (6.5 nmol, i.c.v...
  58. ncbi Radioiodinated substance P, neurokinin A, and eledoisin bind predominantly in NK1 receptors in guinea pig lung
    D P Geraghty
    Department of Biological Sciences, Deakin University, Victoria, Australia
    Mol Pharmacol 41:147-53. 1992
    ..scyliorhinin II much greater than neuropeptide K, indicating binding to sites with the general characteristics of NK1 receptors...
  59. pmc Facilitatory effects of selective agonists for tachykinin receptors on cholinergic neurotransmission: evidence for species differences
    M G Belvisi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 111:103-10. 1994
    ..6 +/- 121%, P < 0.01 and 181.4 +/- 56.5%, P < 0.001 respectively). 4. The NK1 receptor selective agonist, [Sar9]SP sulphone (10 nM) evoked a maximal facilitatory action on cholinergic responses ..
  60. ncbi Functional characterisation of tachykinin receptors mediating ion transport in porcine jejunum
    J E Thorbøll
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Eur J Pharmacol 359:271-9. 1998
    ..The non-peptide NK1 receptor antagonist, CP 99,994 ((2S,3S)-3-(2-methoxybenzyl)amino-2-phenylpiperidine), caused a dextral shift of the ..
  61. pmc Antinociceptive activity of the tachykinin NK1 receptor antagonist, CP-99,994, in conscious gerbils
    N M Rupniak
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex
    Br J Pharmacol 116:1937-43. 1995
    ..enantiomer, CP-100,263, to inhibit spontaneous behaviours and hyperalgesia induced by central infusion of the NK1 receptor agonist, GR73632 or intraplantar injection of formalin was investigated in rats and gerbils. 2...
  62. ncbi Effects of selective tachykinin receptor antagonists on capsaicin- and tachykinin-induced bronchospasm in anaesthetized guinea-pigs
    L Ballati
    Pharmacology Department, Istituto Farmacobiologico Malesci S p A, Firenze, Italy
    Eur J Pharmacol 214:215-21. 1992
    ..capsaicin or selective tachykinin receptor agonists ([Sar9]SP sulfone or [beta-Ala8]neurokinin A (NKA-4-10)) (for NK1 and NK2 receptors, respectively) was studied in anaesthetized guinea-pigs...
  63. pmc Characterization of NK1 and NK2 tachykinin receptors in guinea-pig and rat bronchopulmonary and vascular systems
    A Floch
    Rhone Poulenc Rorer S A, Centre de Recherche de Vitry Alfortville, Vitry sur Seine, France
    Br J Pharmacol 111:759-68. 1994
    1. NK1 and NK2 tachykinin receptors were characterized in guinea-pig and rat bronchopulmonary systems and in the vasculature of the rat by use of radioligand binding and/or functional studies. 2...
  64. pmc Characterization of receptors for kinins and neurokinins in the arterial and venous mesenteric vasculatures of the guinea-pig
    N Berthiaume
    Department of Pharmacology, Medical School, , , Canada
    Br J Pharmacol 115:1319-25. 1995
    ..2. The vasoactive properties of three selective agonists for neurokinin receptors, namely [Sar9, Met (O2)11]SP (NK1), [beta-Ala8]NKA(4-10) (NK2) and [MePhe7]NKB (NK3), were evaluated on precontracted arterial and venous mesenteric ..
  65. ncbi The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity
    Y Tian
    Department of Biotechnology, Parke Davis Pharmaceutical Research, Division of Warner Lambert Co, Ann Arbor, Michigan 48105 1047, USA
    J Biol Chem 271:20250-7. 1996
    Three chimeric receptors were constructed by exchanging exon sequences between human NK1 and NK3 receptor genes...
  66. pmc A non-peptide NK1-receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically
    S M Moussaoui
    Rhone Poulenc Rorer, Centre de Recherche de Vitry Alfortville, Vitry sur Seine, France
    Br J Pharmacol 109:259-64. 1993
    1. The non-peptide neurokinin NK1-receptor antagonist, RP 67580 (3aR, 7aR), a perhydroisoindolone derivative, powerfully reduced plasma extravasation in rat hind paw skin induced by local application of xylene (ID50 = 0.03 mg kg-1, i.v...
  67. ncbi TRPV1 gene knockout impairs postischemic recovery in isolated perfused heart in mice
    Lihong Wang
    Department of Cardiovascular Sciences, First Affiliated Hospital, College of Medicine, Zhejiang University, China
    Circulation 112:3617-23. 2005
    ....
  68. ncbi The tachykinin NK1 receptor in the brain: pharmacology and putative functions
    A Saria
    Department of Psychiatry, University Hospital Innsbruck, Austria
    Eur J Pharmacol 375:51-60. 1999
    ..The receptors described so far are named tachykinin NK1 receptor, tachykinin NK2 receptor and tachykinin NK1 receptor, respectively...
  69. ncbi Increased blocking activity of combined tachykinin NK1- and NK2-receptor antagonists on hyperventilation-induced bronchoconstriction in the guinea pig
    M R Corboz
    Pulmonary and Peripheral Neurobiology, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Pulm Pharmacol Ther 21:67-72. 2008
    In vivo anesthetized guinea pigs were used to investigate the effect of tachykinin NK1- and NK2-receptor antagonists, as a single dose or in combination, against hyperventilation-induced bronchoconstriction (HIB)...
  70. ncbi Changes in the populations of null, NK1.1+, and Thy1lo lymphocytes in the bone marrow of tumor-bearing mice: effect of indomethacin treatment
    M D Rahal
    Department of Anatomy, McGill University, Montreal, Quebec, Canada
    Cell Immunol 139:218-28. 1992
    ..A subset of these cells expresses the natural killer (NK) cell marker, NK1.1. In addition, some rapidly renewed bone marrow lymphocytes express low intensities of Thy1 (Thy1lo)...
  71. ncbi Pharmacological characterization of GR82334, a tachykinin NK1 receptor antagonist, in the isolated spinal cord of the neonatal rat
    J Z Guo
    Department of Pharmacology, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    Eur J Pharmacol 281:49-54. 1995
    ..Pharmacological characteristics of [D-Pro9,[spiro-gamma-lactam]Leu10,Trp11]physalaemin-(1-11) (GR82334), a tachykinin NK1 receptor antagonist, and its effects on slow depolarizing responses of lumbar ventral roots evoked by primary ..
  72. ncbi Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice
    S W Christianson
    Jackson Laboratory, Bar Harbor, Maine
    Cell Immunol 171:186-99. 1996
    ..C57BL/6J-scid/scid mice showed severe loss of mature T and B cells accompanied by increased percentages of NK1.1+ cells and myeloid cells...
  73. ncbi Tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitatory neuromuscular transmission in the human ileum
    V Zagorodnyuk
    Department of Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Neuropeptides 31:265-71. 1997
    Tachykinin NK1 and NK2 receptor selective antagonists and agonists were used to study excitatory non-adrenergic non-cholinergic (NANC) transmission in circular muscle strips from human ileum by the sucrose-gap method...
  74. ncbi Role of tachykinins in the regulation of the hypothalamo-pituitary-adrenal axis
    G G Nussdorfer
    Department of Anatomy, University of Padua, Italy
    Peptides 19:949-68. 1998
    ..are a family of neuropeptides, which act by binding to three main subtypes of G protein-coupled receptors, named NK1, NK2 and NK3...
  75. ncbi Species differences in tachykinin receptor distribution: further evidence that the substance P (NK1) receptor predominates in human brain
    Michael Rigby
    In Vivo Neuroscience, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, United Kingdom
    J Comp Neurol 490:335-53. 2005
    ..We compared the distribution of NK1, NK2, and NK3 receptors in sections from rodent, primate, and human brain using the 125I-labeled ligands substance ..
  76. ncbi The liver as a crucial organ in the first line of host defense: the roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses
    S Seki
    Division of Basic Traumatology, National Defense Medical College Research Institute, Tokorozawa, Japan
    Immunol Rev 174:35-46. 2000
    ..IL-12 and other monokines (IL- 18 etc.) produced by Kupffer cells activate liver natural killer (NK) cells and NK1.1 Ag+ T cells to produce interferon-gamma and thereby acquire cytotoxicity against tumors and microbe-infected ..
  77. ncbi Expression of substance P, neurokinin 1 receptors (NK1) and neurokinin 3 receptors in the developing mouse retina and in the retina of NK1 knockout mice
    E Catalani
    Dipartimento di Scienze Ambientali, Universita della Tuscia, Largo dell Università snc, Blocco D, 01100 Viterbo, Italy
    Neuroscience 138:487-99. 2006
    ..The observations in neurokinin 1 receptor knockout mice may not be applicable to rats or rabbits, and substance P and neurokinin 1 receptor may play different developmental roles in different species...
  78. doi Protein kinase C-mediated inhibition of recombinant T-type Cav3.2 channels by neurokinin 1 receptors
    Azahel Rangel
    Departamento de Fisiologia, Universidad Autonoma de San Luis Potosi, Av Venustiano Carranza, San Luis Potosi, Mexico
    Mol Pharmacol 77:202-10. 2010
    The voltage-activated T-type calcium channel (Ca(V)3.2) and the G protein-coupled neurokinin 1 (NK1) receptor are expressed in peripheral tissues and in central neurons, in which they participate in diverse physiological processes, ..
  79. ncbi GR 73,632 and [Glu(OBzl)11]substance P are selective agonists for the septide-sensitive tachykinin NK1 receptor in the rat urinary bladder
    S Meini
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Neuropeptides 28:99-106. 1995
    The existence of a septide-sensitive subtype of the tachykinin NK1 receptor has been recently proposed...
  80. ncbi Relationship between capsaicin-evoked substance P release and neurokinin 1 receptor internalization in the rat spinal cord
    J C G Marvizón
    Department of Medicine, David Geffen School of Medicine at UCLA, MRL 1240, 675 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 118:535-45. 2003
    ..Substance P release is usually measured by radioimmunoassay, whereas the internalization of the neurokinin 1 (NK1) receptor has been used to assess its activation by noxious stimuli...
  81. ncbi NK1, NK2, NK3 and CGRP1 receptors identified in rat oral soft tissues, and in bone and dental hard tissue cells
    I Fristad
    Department of Odontology Endodontics, School of Dentistry, University of Bergen, Arstadveien 17, 5009, Bergen, Norway
    Cell Tissue Res 311:383-91. 2003
    The distribution of the tachykinin receptors neurokinin-1 (NK1), neurokinin-2 (NK2) and neurokinin-3 (NK3), and the calcitonin gene-related peptide-1 (CGRP1) receptor were examined in rat teeth and tooth-supporting tissues by ..
  82. ncbi Cellular localization and distribution of neurokinin-1 receptors in the rat stomach
    Linda Yip
    Department of Physiology, University of British Columbia, 2146 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
    Auton Neurosci 104:95-108. 2003
    In the stomach, the majority of substance P's effects are mediated by the activation of neurokinin-1 (NK1) receptors...
  83. pmc Targeted deletion of neurokinin-1 receptor expressing nucleus tractus solitarii neurons precludes somatosensory depression of arterial baroreceptor-heart rate reflex
    J T Potts
    Department of Biomedical Science, College of Veterinary Medicine, Dalton Cardiovascular Research Center, University of Missouri, 134 Research Park Drive, Columbia, MO 65211, USA
    Neuroscience 145:1168-81. 2007
    Neurokinin-1 receptor (NK1-R) expressing neurons are densely distributed throughout the nucleus tractus solitarii (NTS). However, their fundamental role in arterial baroreflex function remains debated...
  84. ncbi NK1.1+ cells and T-cell activation in euthymic and thymectomized C57Bl/6 mice during acute Trypanosoma cruzi infection
    F Cardillo
    Department of Immunology, Institute for Biomedical Sciences IV, University of Sao Paulo, 05508 900 USP, Sao Paulo, SP, Brazil
    Scand J Immunol 55:96-104. 2002
    ..killer (NK) cells may provide the basis for resistance to Trypanosoma cruzi infection, because the depletion of NK1.1 cells causes high levels of parasitemia in young C57Bl/6 mice infected with T. cruzi. Indeed, NK1...
  85. ncbi Involvement of spinal tachykinin NK1 and NK2 receptors in detrusor hyperreflexia during chemical cystitis in anaesthetized rats
    A Lecci
    Pharmacology Research Department Menarini Pharmaceuticals, Florence, Italy
    Eur J Pharmacol 259:129-35. 1994
    ..Intrathecal administration of the selective tachykinin NK1 receptor antagonist, GR 82,334 ([D-Pro9(spiro-gamma-lactam)Leu10,Trp11]physalaemin-(1-11)) (1 nmol/rat i.t...
  86. ncbi Substance P (NK1) receptor in relation to substance P innervation in rat duodenum after irradiation
    U Höckerfelt
    Department of Integrative Medical Biology, Anatomy, Umea University, SE 901 87, Umea, Sweden
    Regul Pept 98:115-26. 2001
    ..In the present study the pattern of distribution of NK1 receptors (NK1-R) in rat duodenum after irradiation (5-30 Gy), was examined at the same time-point (7 days) after ..
  87. ncbi Dual tachykinin NK1/NK2 antagonist DNK333 inhibits neurokinin A-induced bronchoconstriction in asthma patients
    G F Joos
    Dept of Respiratory Diseases, Ghent University Hospital, Belgium
    Eur Respir J 23:76-81. 2004
    Inhalation of neurokinin A (NKA) causes bronchoconstriction in patients with asthma. In vitro both tachykinin NK1 and NK2 receptors can mediate airway contraction...
  88. pmc Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists
    Nissar A Darmani
    Department of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA
    Brain Res 1214:58-72. 2008
    Substance P (SP) is thought to play a cardinal role in emesis via the activation of central tachykinin NK1 receptors during the delayed phase of vomiting produced by chemotherapeutics...
  89. pmc Effect of RP 67580, a non-peptide neurokinin1 receptor antagonist, on facilitation of a nociceptive spinal flexion reflex in the rat
    J M Laird
    Department of Pharmacology, Merck, Sharp and Dohme Research Laboratories, Harlow, Essex
    Br J Pharmacol 109:713-8. 1993
    1. In order to examine the contribution of neurokinin1 (NK1) receptors to facilitation of a spinal nociceptive reflex in the rat, we have investigated the effects of RP 67580 (3aR, 7aR)-7,7-diphenyl-2(1-imino-2-(2-methoxyphenyl/ethyl)..
  90. pmc Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4
    T Yoshimoto
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Proc Natl Acad Sci U S A 92:11931-4. 1995
    ..A major source of IL-4 for such differentiation is a population of CD1-specific CD4+ T cells that express NK1.1. These cells produce IL-4 within 90 min of anti-CD3 injection...
  91. pmc Demonstration of a 'septide-sensitive' inflammatory response in rat skin
    A Ahluwalia
    Department of Biochemical Pharmacology, Medical College of St Bartholomew s Hospital, London
    Br J Pharmacol 116:2170-4. 1995
    ..The selective NK1 receptor agonist, [Sar9]SP sulphone was 10-100 times more potent than SP...
  92. ncbi Effect of the non-peptide blocker (+/-) CP 96,345 on the cellular mechanism involved in the response to NK1 receptor stimulation in human skin fibroblasts
    M Ziche
    Department of Pharmacology, Medical School, University of Florence, Italy
    Neuropeptides 30:345-54. 1996
    The effect of the selective non-peptide antagonist for NK1 receptors (+/-)CP 96,345 on cellular transduction mechanisms elicited by the NK1 selective agonist [Sar9]-substance P-sulfone ([Sar9]-SP) was investigated in a stabilized culture ..
  93. ncbi Sequential activation of the triple excitatory transmission to the circular muscle of guinea-pig colon
    C A Maggi
    Pharmacology Department, Menarini Ricerche, Florence, Italy
    Neuroscience 79:263-74. 1997
    ..colon that occurs in response to activation of the intrinsic excitatory nerves by using atropine and tachykinin NK1 and NK2 receptor selective antagonists to define the relative contribution of the transmitters involved...
  94. ncbi Interleukin-12 and protective immunity to schistosomes
    A P Mountford
    Department of Biology, University of York, UK
    Braz J Med Biol Res 31:163-9. 1998
    ..gamma production by natural killer (NK) cells stimulated by IL-12, since in vivo ablation of NK cells using anti-NK1.1 antibody reduced CD4(+)-dependent IFN gamma production from cultured LN cells by over 97%...
  95. ncbi Antiemetic effects of sendide, a peptide tachykinin NK1 receptor antagonist, in the ferret
    M Minami
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Japan
    Eur J Pharmacol 363:49-55. 1998
    The antiemetic activity of sendide, a new peptide tachykinin NK1 receptor antagonist, against cisplatin-induced emesis was investigated using ferrets. The frequency of cisplatin (10 mg/kg, i.p.)-induced retching (104.6 +/- 14...
  96. ncbi Cutting edge: expression of functional CD94/NKG2A inhibitory receptors on fetal NK1.1+Ly-49- cells: a possible mechanism of tolerance during NK cell development
    P V Sivakumar
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Immunol 162:6976-80. 1999
    Fetal liver- and thymus-derived NK1.1+ cells do not express known Ly-49 receptors. Despite the absence of Ly-49 inhibitory receptors, fetal and neonatal NK1...
  97. ncbi Receptors in interstitial cells of Cajal: identification and possible physiological roles
    M G Vannucchi
    Department of Anatomy, Histology and Forensic Medicine, Section of Histology E Allara, University of Florence, Florence, Italy
    Microsc Res Tech 47:325-35. 1999
    ..The ileal ICC, in particular those at the deep muscular plexus, express the tachykinin receptor NK1 and a subtype of somatostatin receptors and contain nitric oxide synthase...
  98. ncbi Evidence for functional NK1-tachykinin receptors on motor neurones supplying the circular muscle of guinea-pig small and large intestine
    X C Bian
    Department of Physiology, University of Melbourne, Parkville, Australia
    Neurogastroenterol Motil 12:307-15. 2000
    The guinea-pig intestine was investigated to determine which neurones are excited via NK1 receptors...
  99. ncbi Effects of tachykinin receptor agonists and antagonists on the guinea-pig isolated oesophagus
    K P Kerr
    Department of Pharmaceutical Biology and Pharmacology, Victorian College of Pharmacy, Monash University, Parkville, Australia
    Clin Exp Pharmacol Physiol 27:934-8. 2000
    ..While this response was unaffected by NK1 and NK2 receptor-selective antagonists, it was only partially inhibited (23%) by the NK3 receptor antagonist SR ..
  100. ncbi Tachykinin NK1 and NK3 receptors in the prefrontal cortex of the human brain
    P A Tooney
    Neuroscience Institute of Schizophrenia and Allied Disorders and School of Biomedical Sciences, Faculty of Medicine and Health Sciences, The University of Newcastle, Callaghan, New South Wales, Australia
    Clin Exp Pharmacol Physiol 27:947-9. 2000
    ..receptors has been described in the brains of various animal species, little is known about the distribution of the NK1 and NK3 receptors in the human brain. 3...
  101. ncbi A thymic precursor to the NK T cell lineage
    Kamel Benlagha
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Science 296:553-5. 2002
    CD1d-restricted autoreactive natural killer (NK1.1+) T cells function as regulatory cells in various disease conditions. Using improved tetramer tracking methodology, we identified a NK1...

Research Grants65

  1. Anti-HIV Neuroimmunomodulatory Therapy with Neurokinin-1 (NK1-R) Antagonists
    STEVEN DANIEL DOUGLAS; Fiscal Year: 2013
    ..This NK1RA has activity as an antiviral HIV agent that improves innate immunity (Natural Killer cells) and has positive neurobehavioral effects. NK1RA are a potential novel therapy for neuroAIDS...
  2. Kerry J Ressler; Fiscal Year: 2014
    ..Previously, other tachykinin pathways, such as neurokinin 1 receptor (NK1) and substance P, have been described to be involved in fear processes...
  3. Nanoparticle mediated in vivo cell-type specific drug delivery for pain relief
    Zhigang David Luo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Existing data support a critical role of neurokinin 1 receptor (NK1 receptor) expressing neurons in the dorsal spinal cord in mediating pain processing...
  4. PHYSIOLOGICAL CORRELATES OF NEURAL PLASTICITY
    LILLIAN PUBOLS; Fiscal Year: 1993
    ..2. Similar experiments will be performed using ligands that are specific for NK1, NK2, and NK3 tachykinin receptors, in place of substance P. 3...
  5. Nancy J Brown; Fiscal Year: 2014
    ..increased sensitivity to ACE inhibitor- induced peritracheal edema, an effect that is reversed by a substance P (NK1) receptor antagonist...
  6. NEUROPEPTIDERGIC INHIBITION OF SPINAL PAIN TRANSMISSION
    Bradley K Taylor; Fiscal Year: 2013
    ..receptor coupling to G-proteins (Aim 2);the effect of injury on the inhibition by NPY of SP release and subsequent NK1 receptor (NK1) activation in the spinal cord (Aim 3A);and the effect of NPY on the activity of spinal neurons that ..
  7. Neuronal Changes in Adult Rats Induced by Neonatal Pain
    Adrian Miranda; Fiscal Year: 2011
    ..It is hypothesized that noxious stimulation early in development results in increased expression of NMDA and NK1 receptors and the neuropeptide substance P in the thoraco-lumbar spinal cord...
  8. Barbara J Mason; Fiscal Year: 2015
    ..double-blind, placebo-controlled randomized clinical trial is to evaluate the efficacy of a novel neurokinin1 (NK1) receptor antagonist, vofopitant (5mg/day), for treating CD in 100 outpatients with current CD...
  9. Tony L Yaksh; Fiscal Year: 2014
    ..Akt, GSK/2 and mTOR after intraplantar formalin with the acute spinal delivery of: i) 5 agonist;ii) blockers of NK1, glutamatergic ionotropic or metabotrophic excitatory receptors. 4...
  10. Victor J Hruby; Fiscal Year: 2015
    ..Increased signaling through the substance P-NK1 pathway strongly contributes to peripheral and central sensitization to enhance pain...
  11. Role of Medullary Substance P in Acute and Persistent Nociception
    Donna L Hammond; Fiscal Year: 2012
    ..and duration of SubP effects in the RVM of rats in the uninjured state, and confirm the role of neurokinin-1 (NK1) receptors...
  12. Tachykinin regulation of anxiety and stress responses
    MARK HEATH; Fiscal Year: 2006
    ..We previously generated a line of mice that are lacking the gene for the neurokinin 1 (NK1) receptor, a protein that belongs to a family called the tachykinin receptors...
  13. New Neural Targets for Opioid Use Disorders: Human Studies
    Sharon L Walsh; Fiscal Year: 2010
    ..Recent evidence suggests that inactivation of substance P receptors (NK1), either through genetic deletion or pharmacological blockade, significantly attenuates the rewarding effects of ..
  14. NK Cell Control of Acute Influenza Virus Infection
    Jonathan W Heusel; Fiscal Year: 2010
    ..B6-CT6 (NK1.1+) mice and ex vivo intact lymph node culture to isolate NK cell responses and functions through three Specific ..
  15. Mitchell Kronenberg; Fiscal Year: 2015
    ..HVEM is a key but under studied player in mucosal immunity, but our experimental results will untangle the network of HVEM-mediated interactions to reveal the means by which it regulates mucosal inflammation. ..
  16. FUNCTIONAL DEVELOPMENT OF NATURAL KILLER CELLS
    Amy Reichlin; Fiscal Year: 1999
    ..The NK1.1 molecule is the most specific marker on murine NK cells...
  17. ORGIN AND DIFFERENTIATION OF NATURAL KILLER CELLS
    Vinay Kumar; Fiscal Year: 2003
    ..Flt3+ NK progenitors differentiate into IL-15 responsive NK precursors in vitro. These cells are NK1.1-, IL2/15Rbeta+...
  18. PEPTIDERGIC NEURONS IN THE SPINAL CORD
    VIRGINIA SEYBOLD; Fiscal Year: 1999
    ..of neurokinin receptors with respect to nociceptive pathways in the spinal cord and explores how the function of NK1 receptors is enhanced during persistent hyperalgesia...
  19. ULTRASTRUCTURE OF MESOLIMBIC TRANSMITTER INTERACTIONS
    Virginia M Pickel; Fiscal Year: 2012
    ..that are activated not only by glutamate, but also by aversion-associated peptides interacting with neurokinin-1 (NK1) receptors...
  20. Plasticity of micturition-related neurons following spinal cord injury
    Paul C Dolber; Fiscal Year: 2012
    ..reflex undergo central sensitization so that they become responsive to preemptive treatment against NMDA receptors, NK1 receptors, and reactive oxygen species. The specific objectives to attain these goals are: Specific objective 1...
  21. Carl F Ware; Fiscal Year: 2016
    ..We have established a highly interactive group of virologists and autoimmune disease specialists as collaborators to assist in the experimental approach and data analysis. ..
  22. Elizabeth M Gardner; Fiscal Year: 2014
    ..Importantly, in vivo NK cell depletion by anti-NK1.1 IgG antibody (PK136) treatment induced marked weight loss and increased lung virus titers after influenza ..
  23. Fu Dong Shi; Fiscal Year: 2014
    ..We demonstrated that the systemic depletion of NK cells in all organ system using an anti-NK1.1 mAb, or selectively reduced the homing of NK cells to the CNS through a germ-line deletion of the chemokine ..
  24. Trigeminal - RVM involvement in bilateral deep tissue orofacial hyperalgesia
    Bryan Chai; Fiscal Year: 2012
    ..Specific aim 2 will investigate whether NK1-R activation in the RVM is necessary for the development of bilateral orofacial hyperalgesia...
  25. Jennifer R Cochran; Fiscal Year: 2014
    ..To develop robust Met-targeting agents we used the N- terminal and first Kringle domain (NK1) of the natural Met activating ligand, hepatocyte growth factor (HGF), as a basis for engineering potent Met ..
  26. Nociceptive Mechanisms in Whiplash Injury
    Beth A Winkelstein; Fiscal Year: 2013
    ..In Aim 2 we use saporin conjugates in separate studies to selectively eliminate NK1 receptor-bearing and IB4-positive neurons in the facet joint and define their relative contributions to pain and ..
  27. Mechanisms of Immune Regulation in Mycobacterium Tuberculosis Infection
    CHERYL LIANE DAY; Fiscal Year: 2012
    ....
  28. MOLECULAR MECHANISMS OF MHC LINKED SUSCEPTIBILITY
    Kai Wucherpfennig; Fiscal Year: 2001
    ..b>NK1.1+ T cells are of particular interest because they are the major source of IL-4 for the differentiation of naive T ..
  29. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..and dura vasodilation with or without pretreatment with the CRH receptor antagonist Astressin or the nonpeptide NK1-receptor antagonist SR 140...
  30. Medications Development for the Treatment of Cannabis Related Disorders
    HEATHER MAY HAUGHEY; Fiscal Year: 2010
    ..to perform a pilot clinical trial of medication to target a neuromodulator of stress in the CNS, the neurokinin 1 (NK1) receptor system...
  31. Immune regulation by thymocyte-selected CD4 T cells
    Cheong Hee Chang; Fiscal Year: 2013
    ..are distinct from NKT cells since T-CD4 T cells require MHC class II-peptide complexes to develop, do not express NK1.1, and have a diverse TCR repertoire...
  32. WILLIAM GARROW KERR; Fiscal Year: 2014
    ..unexpected observation that SHIP is required for effective induction of 3-IFN by major NK activating receptors like NK1.1, NCR1/NKp46 and NKG2D...
  33. ESOPHAGO-LARYNGEAL ADDUCTOR REFLEX
    Nancy Bauman; Fiscal Year: 2000
    ..distal esophageal nociceptive stimulation with capsaicin before and after chemically antagonizing their substance P NK1 receptors...
  34. CALCITONIN GENE-RELATED PEPTIDE IN HYPERTENSION
    Gianfranco Alpini; Fiscal Year: 2006
    ..test this hypothesis, we will determine whether decreased CGRP or SP function (by studying CGRP KO and SP receptor (NK1) KO mice) alters the ability of the sensory nervous system to modulate BP in the absence or presence of ..
  35. MOLECULAR CHARACTERIZATION OF THE A1 MULTIGENE FAMILY
    Wayne Yokoyama; Fiscal Year: 1993
    ..multigene family maps to a contiguous stretch of mouse chromosome 6 to which another lymphoid cell surface antigen, NK1.1, also maps. The NK1.1 antigen is the most specific marker of murine NK cells, and since the NK1...
  36. VAGAL GASTRIC MOTOR CONTROL IN MICE
    ELITA PARTOSEOEDARSO; Fiscal Year: 2002
    ..The first hypothesis is that gastric relaxation is evoked by GABAb and NK1 receptors in neurons of the dorsal motor nucleus of the vagus (DMN) of mice...
  37. Targeted Cholera Toxin for Treatment of Hyperalgesia
    Robert Caudle; Fiscal Year: 2004
    ..pain, and that toxins can be directly targeted to nociceptive neurons in the spinal cord via the neurokinin 1 (NK1) receptor...
  38. Immunologic Factors In Progressive Autoimmune Disease
    ROBERT FUJINAMI; Fiscal Year: 2005
    ..To test this hypothesis, four specific aims are proposed. The first aim will study the role of NK1.1+ T cells in progressive disease...
  39. Cellular Regulation of Mu Opioid Receptors
    YUNHUA YU; Fiscal Year: 2009
    ..MORs are co-expressed with neurokinin 1 (NK1) receptors in several regions of the central nervous system (CNS), including a subset of neurons in the striatum, a ..
  40. Natural Killer Dendritic Cells in Listeria Infection
    Ronald DeMatteo; Fiscal Year: 2007
    ..lyse targets directly, activate naive T cells in vitro and in vivo, and express both the natural killer cell marker NK1.1 and the dendritic cell marker CD11c, we have labeled them as natural killer dendritic cells (NKDC)...
  41. BIFUNCTIONAL OPIOID PEPTIDE ANALGESICS
    Peter Schiller; Fiscal Year: 2009
    ..can be reduced by co-administration of a d opioid antagonist, a cannabinoid (CB1) antagonist, a substance P (NK1) antagonist or an opioid receptor like (ORL1) antagonist...
  42. Cathepsins in Antigen Presentation and Lung Immunity
    Manuela Cernadas; Fiscal Year: 2007
    ..mice also exhibit abnormal endosomal trafficking of CD ld molecules, resulting in defective selection of NK1.1 +T cells...
  43. IMMUNE FUNCTION IN ALLERGIC ENCEPHALOMYELITIS
    Robert Fritz; Fiscal Year: 2003
    ..of the regulatory cell population in wild-type mice indicates that the phenotype of the regulatory cell is CD4- CD8-NK1.1+alpha/betaTCR+ or CD4-CD8+NK1.1+alpha/betaTCR+...
  44. Clinical laboratory evaluations of aprepitant for the treatment of opioid depende
    Stephen Ross; Fiscal Year: 2013
    ..Recent pre-clinical studies have demonstrated the involvement of the NK1 rector in opioid reward and withdrawal...
  45. NKT cells: Novel Protective T cells against malaria
    Moriya Tsuji; Fiscal Year: 2001
    ..Murine NKT cells express the NK marker (NK1.l) and, in most instances, a single invariant T cell receptor encoded by the Va14 and Ja281 gene segments...
  46. Glycosylation of NK1 Receptors: Chemistry and Function
    Susan Leeman; Fiscal Year: 2004
    ..The activities of SP depend upon interaction with its 7-transmembrane G-protein coupled receptor, the NK1 receptor (NK1R)...
  47. NEW TOOLS FOR PROBING PEPTIDE-PROTEIN INTERACTIONS
    KEVIN MOELLER; Fiscal Year: 1999
    ..Specifically, the thyrotropin releasing hormone 7-TM receptor TRH-R and the substance P 7-TM receptor NK1 will be studied...
  48. Vanilloid Receptors in Nociception
    Juli Valtschanoff; Fiscal Year: 2004
    ..microscopy, whether VR1- and SP-immunopositive terminals contact the same neuron expressing neurokinin receptors (NK1) in lamina I...
  49. FUNCTION OF BY55 IN THE DEVELOPMENT OF CYTOLYTIC T CELLS
    Gordon Freeman; Fiscal Year: 1999
    DESCRIPTION (applicant's abstract): The overall goal of this proposal is to determine whether BY55 (a novel cell surface marker) can serve as a means to define the differentiative pathway, potency, and expansion potential of CD8+ T cell ..
  50. Dendritic Varicosities Regulate Neuronal Excitability
    HERBERT PROUDFIT; Fiscal Year: 2006
    ..will use conventional and confocal light microscopic analyses to determine (1) the timecourse of DV formation in NK1-ir RVM GABA neurons, (2) the ability of microtubule stabilizing drugs, such as taxol, to prevent the formation of ..
  51. DEVELOPMENT & CONTROL OF NATURAL ANTOREACTIVE B T CELL
    Kyoko Hayakawa; Fiscal Year: 2001
    ..Our recent data suggest that NK1.1+ alpha beta cells, capable of TH2 cell induction and cytotoxicity, may represent the ultimate fate of Thy0...
  52. Do NKT cells mediate UV induced Immune Suppression?
    Stephen Ullrich; Fiscal Year: 2005
    ..Our preliminary findings indicate that a highly purified population of NK1 cells can transfer suppression of tumor immunity from UV-irradiated mice to normal recipients...
  53. MACROPHAGE AND NK CELL RESISTANCE VS HERPESVIRUSES
    Page Morahan; Fiscal Year: 1991
    ..89Sr to "marrow- ectomize" mice, with those obtained by using two novel depletion methods--monoclonal antibody NK1.1 to deplete mice selectively of NK cells, and dimethylene diphosphate (DMDP) toxin encapsulated in liposomes to ..
  54. TRANSMEMBRANE SIGNALING BY LY-49
    William Seaman; Fiscal Year: 1999
    ..They have created a chimeric receptor, linking the extracellular domain of NK1.1 to the transmembrane and cytoplasmic domains of mLy-49A, and have used this model to demonstrate a role for the ..
  55. Natural Killer Dendritic Cells in Cancer
    BRYAN BURT; Fiscal Year: 2007
    ..We have found cells expressing both the natural killer (NK) cell marker NK1.1 as well as the dendritic cell (DC) marker CD11c, in multiple organs of normal mice...
  56. H-2 GENES AND T CELL SELECTION
    David Raulet; Fiscal Year: 1999
    ..relatively well understood, little is known concerning a discrete population of mature T cells that expresses the NK1.1 antigen. This population includes CD4-CD8-TCRalpha-beta+ cells as well as CD4+CD8-TCRalpha-beta+ cells...
  57. Targeting SP-NK1R-EGFR interactions in colitis associated dysplasia
    BEATRIZ PAGAN; Fiscal Year: 2009
    ..The specific aims of the proposed plan are to: 1) to investigate the role of NK1 receptors in our model of colitis-associated dysplasia versus chronic inflammation;2) to analyze the role of EGFR ..
  58. Keratinocyte-derived immuno-suppressive cytokines
    Stephen Ullrich; Fiscal Year: 2005
    ..the cellular source of the UV-induced serum IL-4? Is cytokine secretion by circulating T cells, mast cells and/or NK1. I cells involved in transmitting the suppressive signal from the skin to immune elements? 3) Is the inability of ..
  59. Imaging Spontaneous Breast Cancer in Mouse Models
    Christopher Contag; Fiscal Year: 2002
    ..process and in particular the mechanism(s) of anti-tumor activity of ex vivo expanded T cell populations (CD3+CD8+NK1.l+ NK-like T cells) will be evaluated as a model of immune surveillance...
  60. MECHANISMS OF CANNABINOID'S ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2007
    ..can potentiate the antivomiting efficacy of established antiemetics (serotonin 5-HT3-, dopamine D2- and neurokinin NK1-receptor antagonists and dexamethasone) against chemo- and radiotherapy-induced vomiting; 3) Determination of ..
  61. Emotion, Pain and Pain Control Circuits
    KATHRYN COMMONS; Fiscal Year: 2003
    ..When released, SP binds the neurokinin 1 (NK1) receptor and precipitates receptor activation and internalization...
  62. MECHANISMS OF CANNABINOIDS ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2001
    ..The results will define an important role for the cannabinoid receptors in the vomiting circuits and may implicate an antiemetic role for the endogenous cannabinoids. ..
  63. Injury Induced Facilitated Neurogenic Inflammation
    Wade Kingery; Fiscal Year: 2006
    ..abstract_text> ..
  64. NEURAL REGULATION OF BONE REMODELING
    Wade Kingery; Fiscal Year: 2008
    ..These investigations will help to identify the sensory transmitters that modulate bone remodeling and characterize their roles in osteoporotic processes. ..
  65. SYNAPTIC CONNECTIONS OF SPINAL CORD NEURONS
    William Willis; Fiscal Year: 2007
    ..Preliminary evidence supports the feasibility of the work and suggests that the results could lead to a number of new targets for improvements in pain therapy. ..