butyrylcholinesterase

Summary

Gene Symbol: butyrylcholinesterase
Description: butyrylcholinesterase
Alias: CHE1, CHE2, cholinesterase, acylcholine acylhydrolase, butyrylcholine esterase, choline esterase II, cholinesterase (serum) 2, cholinesterase 1, pseudocholinesterase
Species: human

Top Publications

  1. ncbi Tissue cholinesterases. A comparative study of their kinetic properties
    K R Dave
    Department of Biochemistry, Faculty of Science, M S University of Baroda, Vadodara, India
    Z Naturforsch C 55:100-8. 2000
  2. ncbi The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26
    P W Allderdice
    Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
    Genomics 11:452-4. 1991
  3. ncbi Structure of the gene for human butyrylcholinesterase. Evidence for a single copy
    M Arpagaus
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109 0626
    Biochemistry 29:124-31. 1990
  4. ncbi Butyrylcholinesterase-Mediated enhancement of the enzymatic activity of trypsin
    S Darvesh
    Department of Medicine, Halifax, Nova Scotia, Canada
    Cell Mol Neurobiol 21:285-96. 2001
  5. ncbi Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains
    Estifanos Ghebremedhin
    Department of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Neurosci Lett 320:25-8. 2002
  6. ncbi Rapid simultaneous genotyping of the frequent butyrylcholinesterase variants Asp70Gly and Ala539Thr with fluorescent hybridization probes
    M R Gätke
    Department of Anaesthesia, Center of Head and Orthopaedics, Rigshospitalet, Denmark
    Scand J Clin Lab Invest 62:375-83. 2002
  7. ncbi Regulation of attention and response to therapy in dementia by butyrylcholinesterase
    Kirsty K O'Brien
    MRC Building, MRC University of Newcastle Centre Development for Clinical Brain Ageing, Newcastle upon Tyne, NE1 3BZ, UK
    Pharmacogenetics 13:231-9. 2003
  8. ncbi Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products
    Yvain Nicolet
    Laboratoire de Cristallographie et Cristallogenese des Proteines, Institut de Biologie Structurale Jean Pierre Ebel, CEA, UJF, CNRS, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    J Biol Chem 278:41141-7. 2003
  9. ncbi Frequency and enzyme activity of the butyrylcholinesterase K-variant in a Turkish population
    Melih O Babaoglu
    Department of Pharmacology, Hacettepe University Faculty of Medicine, Sihhiye, 06100 Ankara, Turkey
    Eur J Clin Pharmacol 59:875-7. 2004
  10. ncbi On the active site for hydrolysis of aryl amides and choline esters by human cholinesterases
    Sultan Darvesh
    Department of Medicine Neurology, Dalhousie University, Halifax, NS, Canada
    Bioorg Med Chem 14:4586-99. 2006

Research Grants

  1. Enhanced bioscavenger for medical countermeasures against organophosphorus agents
    Zhiguo Zhou; Fiscal Year: 2013
  2. A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide Neurotoxicity
    Yvonne Rosenberg; Fiscal Year: 2007
  3. Central cholinergic function in AChE-deficient mice
    Jochen Klein; Fiscal Year: 2006
  4. Optimization of nonpyridinium oximes for BChE hydrolysis of OPs in plasma
    PALMER WILLIAM TAYLOR; Fiscal Year: 2012
  5. Aerosol Delivery of a Recombinant Butyrylcholinesterase "BioShield" to Protect Ag
    YVONNE J ROSENBERG; Fiscal Year: 2012
  6. YVONNE J ROSENBERG; Fiscal Year: 2015
  7. WILLIAM STEPHEN BRIMIJOIN; Fiscal Year: 2014
  8. Chang Guo Zhan; Fiscal Year: 2015
  9. Chang Guo Zhan; Fiscal Year: 2015
  10. EVALUATION OF PROTEIN BASED MEDICATIONS AGAINST COCAINE
    James Woods; Fiscal Year: 2003

Detail Information

Publications253 found, 100 shown here

  1. ncbi Tissue cholinesterases. A comparative study of their kinetic properties
    K R Dave
    Department of Biochemistry, Faculty of Science, M S University of Baroda, Vadodara, India
    Z Naturforsch C 55:100-8. 2000
    ..kinetic properties of soluble and membrane-bound forms of acetylcholinestarase (AChE) from brain and butyrylcholinesterase (BChE) from heart and liver were examined...
  2. ncbi The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26
    P W Allderdice
    Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
    Genomics 11:452-4. 1991
    Human tissues have two distinct cholinesterase activities: acetylcholinesterase and butyrylcholinesterase. Acetylcholinesterase functions in the transmission of nerve impulses, whereas the physiological function of butyryl-cholinesterase ..
  3. ncbi Structure of the gene for human butyrylcholinesterase. Evidence for a single copy
    M Arpagaus
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109 0626
    Biochemistry 29:124-31. 1990
    We have isolated five genomic clones for human butyrylcholinesterase (BChE), using cDNA probes encoding the catalytic subunit of the hydrophilic tetramer [McTiernan et al. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 6682-6686]...
  4. ncbi Butyrylcholinesterase-Mediated enhancement of the enzymatic activity of trypsin
    S Darvesh
    Department of Medicine, Halifax, Nova Scotia, Canada
    Cell Mol Neurobiol 21:285-96. 2001
    1. Acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BuChE, EC 3.1.1.8) are enzymes that catalyze the hydrolysis of esters of choline. 2. Both AChE and BuChE have been shown to copurify with peptidases. 3...
  5. ncbi Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains
    Estifanos Ghebremedhin
    Department of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Neurosci Lett 320:25-8. 2002
    The association between the K-variant of the butyrylcholinesterase gene (BCHE-K) and Alzheimer disease (AD) or AD-related neuropathology has been reported to date with conflicting results...
  6. ncbi Rapid simultaneous genotyping of the frequent butyrylcholinesterase variants Asp70Gly and Ala539Thr with fluorescent hybridization probes
    M R Gätke
    Department of Anaesthesia, Center of Head and Orthopaedics, Rigshospitalet, Denmark
    Scand J Clin Lab Invest 62:375-83. 2002
    The clinically important variants of butyrylcholinesterase (BChE) are the A- (Asp70Gly) and K-variants (Ala539Thr), which are common among Caucasians...
  7. ncbi Regulation of attention and response to therapy in dementia by butyrylcholinesterase
    Kirsty K O'Brien
    MRC Building, MRC University of Newcastle Centre Development for Clinical Brain Ageing, Newcastle upon Tyne, NE1 3BZ, UK
    Pharmacogenetics 13:231-9. 2003
    To determine the response of patients with different butyrylcholinesterase genotypes to therapy, and the influence of butyrylcholinesterase on cognition...
  8. ncbi Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products
    Yvain Nicolet
    Laboratoire de Cristallographie et Cristallogenese des Proteines, Institut de Biologie Structurale Jean Pierre Ebel, CEA, UJF, CNRS, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    J Biol Chem 278:41141-7. 2003
    ..two groups: acetylcholinesterase, involved in the hydrolysis of the neurotransmitter acetylcholine, and butyrylcholinesterase of unknown function...
  9. ncbi Frequency and enzyme activity of the butyrylcholinesterase K-variant in a Turkish population
    Melih O Babaoglu
    Department of Pharmacology, Hacettepe University Faculty of Medicine, Sihhiye, 06100 Ankara, Turkey
    Eur J Clin Pharmacol 59:875-7. 2004
    Among variants of the butyrylcholinesterase gene ( BChE), the K-variant causing Ala539Thr substitution is the most common one associated with about one-third reduction in the enzyme activity...
  10. ncbi On the active site for hydrolysis of aryl amides and choline esters by human cholinesterases
    Sultan Darvesh
    Department of Medicine Neurology, Dalhousie University, Halifax, NS, Canada
    Bioorg Med Chem 14:4586-99. 2006
    ..It has been speculated that the AAA activity, especially that of butyrylcholinesterase (BuChE), may be important in the development of the nervous system and in pathological processes such as ..
  11. pmc Butyrylcholinesterase attenuates amyloid fibril formation in vitro
    Sophia Diamant
    Department of Biological Chemistry, Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 103:8628-33. 2006
    In Alzheimer's disease, both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) colocalize with brain fibrils of amyloid-beta (Abeta) peptides, and synaptic AChE-S facilitates fibril formation by association with insoluble ..
  12. ncbi Serum butyrylcholinesterase is strongly associated with adiposity, the serum lipid profile and insulin resistance
    Tomoyuki Iwasaki
    Department of Endocrinology and Metabolism, Yokohama City University Graduate School of Medicine
    Intern Med 46:1633-9. 2007
    We investigated the association between the serum butyrylcholinesterase (BChE) activity and parameters of adiposity, insulin resistance and the serum lipid profile, including the serum levels of triglyceride (TG), HDL-cholesterol (HDL-C) ..
  13. ncbi Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers
    He Li
    Eppley Institute and Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Biochem J 411:425-32. 2008
    BChE (butyrylcholinesterase) protects the cholinergic nervous system from organophosphorus nerve agents by scavenging these toxins...
  14. doi Human recombinant butyrylcholinesterase purified from the milk of transgenic goats interacts with beta-amyloid fibrils and suppresses their formation in vitro
    E Podoly
    Alexander Silberman Life Sciences Institute, Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel
    Neurodegener Dis 5:232-6. 2008
    In Alzheimer's disease (AD), brain butyrylcholinesterase (BChE) co-localizes with beta-amyloid (Abeta) fibrils.
  15. doi Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease
    Roger Lane
    Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936 1080, USA
    Pharmacogenet Genomics 18:289-98. 2008
    To evaluate the synergistic effects of the apolipoprotein E (APOE) epsilon4 and butyrylcholinesterase K-variant (BCHE-K) alleles on progression to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI).
  16. doi Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patients
    Andrea Tasker
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neurosci Lett 442:297-9. 2008
    There is evidence to suggest an involvement of the K variant of the butyrylcholinesterase gene (BCHE) in dementia. We have examined the relationship between BCHE genotype and butyrylcholinesterase (BuChE) activity in autopsy brain tissue...
  17. doi The apolipoprotein E ε4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase
    Taher Darreh-Shori
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Sweden
    Neurobiol Aging 32:1236-48. 2011
    ..Certain butyrylcholinesterase (BuChE) polymorphisms together with the ApoE ε4 allele synergistically increase the risk of AD...
  18. doi Differential levels of apolipoprotein E and butyrylcholinesterase show strong association with pathological signs of Alzheimer's disease in the brain in vivo
    Taher Darreh-Shori
    Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 32:2320.e15-32. 2011
    ..E (ApoE) ε4, and female gender, are associated with differential levels of ApoE proteins and butyrylcholinesterase (BuChE) in the cerebrospinal fluid (CSF) of AD patients...
  19. pmc GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors
    Beben Benyamin
    Queensland Institute of Medical Research, Brisbane 4006, Australia
    Hum Mol Genet 20:4504-14. 2011
    Serum butyrylcholinesterase (BCHE) activity is associated with obesity, blood pressure and biomarkers of cardiovascular and diabetes risk...
  20. pmc Butyrylcholinesterase is associated with β-amyloid plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer disease
    Sultan Darvesh
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Neuropathol Exp Neurol 71:2-14. 2012
    Histochemical analysis of Alzheimer disease (AD) brain tissues indicates that butyrylcholinesterase (BuChE) is present in β-amyloid (Aβ) plaques...
  21. pmc Rate of progression of cognitive decline in Alzheimer's disease: effect of butyrylcholinesterase K gene variation
    C Holmes
    University of Southampton, Clinical Neurosciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Botley Road, Southampton, UK
    J Neurol Neurosurg Psychiatry 76:640-3. 2005
    To determine whether individuals with Alzheimer's disease (AD) and the K variant allele of butyrylcholinesterase have a slower rate of cognitive decline than those without the K variant allele of butyrylcholinesterase.
  22. pmc Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning
    Yue Jin Huang
    PharmAthene Canada, Inc, 7150 Alexander Fleming, Montreal, QC, Canada H4S 2C8
    Proc Natl Acad Sci U S A 104:13603-8. 2007
    ..Because exposure to OP could create a danger for humans in the future, butyrylcholinesterase (BChE) has been developed for prophylaxis to these chemicals...
  23. doi No differences of butyrylcholinesterase protein activity and allele frequency in Lewy body diseases
    Walter Maetzler
    Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Otfried Muller Strasse 27, Tuebingen D 72076, Germany
    Neurobiol Dis 35:296-301. 2009
    b>Butyrylcholinesterase (BChE) genotypes and protein (BuChE) activity, especially in combination with Apolipoprotein E4 (ApoE4), have been investigated as risk factors for developing Alzheimer disease (AD) and may be associated with the ..
  24. ncbi Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman
    Richard K Gordon
    Walter Reed Army Institute of Research, Division of Biochemistry, 503 Robert Grant Rd, Silver Spring, MD 20910 7500, USA
    Chem Biol Interact 157:239-46. 2005
    Cholinesterases (ChEs) are classified as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) according to their substrate specificity and sensitivity to selected inhibitors...
  25. ncbi Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon
    G Amitai
    Division of Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
    Biochem Pharmacol 56:293-9. 1998
    ..We have examined the kinetics of inhibition of AChE and butyrylcholinesterase (BChE) by paraoxon and CPO...
  26. ncbi Activity of essential oils and individual components against acetyl- and butyrylcholinesterase
    Ilkay Orhan
    Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey
    Z Naturforsch C 63:547-53. 2008
    We have tested acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of nineteen essential oils obtained from cultivated plants, namely one from Anethum graveolens L...
  27. ncbi Does "butyrylization" of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase?
    D Kaplan
    Departments of Biochemistry and Molecular Genetics and Organic Chemistry, Israel Institute for Biological Research, Ness Ziona 74100, Israel
    Biochemistry 40:7433-45. 2001
    ..human acetylcholinesterase (HuAChE) is lined by 14 aromatic residues, whereas in the closely related human butyrylcholinesterase (HuBChE) 3 of the aromatic active center residues (Phe295, Phe297, Tyr337) as well as 3 of the residues at ..
  28. ncbi Blood and bronchoalveolar lavage fluid acetylcholinesterase levels following microinstillation inhalation exposure to sarin in Guinea pigs
    Magnus M Che
    Division of Biochemistry, Department of Biochemical Pharmacology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Inhal Toxicol 20:821-8. 2008
    We determined acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition in the bronchoalveolar lavage fluid (BALF) following inhalation exposure to chemical threat nerve agent (CTNA) sarin...
  29. doi Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase
    Julian R Haigh
    Walter Reed Army Institute of Research, Division of Biochemistry, 503 Robert Grant Road, Silver Spring, MD 20910 7500, USA
    Chem Biol Interact 175:380-6. 2008
    ..Using the WRAIR whole blood cholinesterase assay, red blood cell AChE and plasma butyrylcholinesterase (BChE) were measured in unprocessed whole blood samples from the volunteers following each dose, and then ..
  30. ncbi Comparative study of acetylcholinesterase and butyrylcholinesterase in brain and serum of several freshwater fish: specific activities and in vitro inhibition by DDVP, an organophosphorus pesticide
    G M Chuiko
    The Institute of Wildlife and Environmental Toxicology TIWET, Clemson University, Pendleton, SC 29670, USA
    Comp Biochem Physiol C Toxicol Pharmacol 127:233-42. 2000
    ..1.1.7) and serum butyrylcholinesterase (BChE; EC 3.1.1...
  31. ncbi Acetylcholinesterase and butyrylcholinesterase expression in adult rabbit tissues and during development
    O Jbilo
    Laboratorire de Différenciation cellulaire et Croissance, INRA, Montpellier, France
    Eur J Biochem 225:115-24. 1994
    ..This sequence was compared to that of rabbit butyrylcholinesterase [BChE; Jbilo, O. & Chatonnet, A. (1990) Nucleic Acids Res. 18, 3990]...
  32. pmc Fundamental reaction mechanism for cocaine hydrolysis in human butyrylcholinesterase
    Chang Guo Zhan
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Am Chem Soc 125:2462-74. 2003
    b>Butyrylcholinesterase (BChE)-cocaine binding and the fundamental pathway for BChE-catalyzed hydrolysis of cocaine have been studied by molecular modeling, molecular dynamics (MD) simulations, and ab initio calculations...
  33. pmc Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase
    Nora H Barakat
    Human BioMolecular Research Institute, San Diego, California 92121, USA
    Chem Res Toxicol 22:1669-79. 2009
    ..are generally more potent inhibitors than their R(p) counterparts toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)...
  34. pmc Cholinesterase activity in human pulmonary arteries and veins
    L Walch
    CNRS ERS 566, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France
    Br J Pharmacol 121:986-90. 1997
    ..In addition, kinetic parameters were determined for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in human pulmonary vessel homogenates. 2...
  35. ncbi Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse
    B Li
    Eppley Institute, University of Nebraska Medical Center, Omaha 68198 6805, USA
    J Neurochem 75:1320-31. 2000
    ..While comparing the tissue distribution of AChE and butyrylcholinesterase (BChE), we found that extraction buffers containing Triton X-100 strongly inhibited mouse BChE activity...
  36. ncbi Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase
    C B Millard
    United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010 5425, USA
    Biochemistry 37:237-47. 1998
    ..By placing a His near the oxyanion hole of human butyrylcholinesterase (BChE), we made an esterase (G117H) that catalyzed the hydrolysis of several OP, including sarin and VX [..
  37. ncbi The NMDA receptor ion channel: a site for binding of Huperzine A
    R K Gordon
    Division of Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
    J Appl Toxicol 21:S47-51. 2001
    ..moss Huperzia serrata, is a potent, reversible and selective inhibitor of acetylcholinesterase (AChE) over butyrylcholinesterase (BChE) (Life Sci. 54: 991-997)...
  38. ncbi Evaluating reptile exposure to cholinesterase-inhibiting agrochemicals by serum butyrylcholinesterase activity
    Juan C Sanchez-Hernandez
    Laboratory of Ecotoxicology, Department of Environmental Science, University of Castilla La Mancha, Avda Carlos III, 54071, Toledo, Spain
    Environ Toxicol Chem 22:296-301. 2003
    ..del Hidalgo) and two reference areas on the Island of Tenerife (Canary Islands, Spain) were analyzed for butyrylcholinesterase (BChE) activity...
  39. ncbi Malathion, carbofuran and paraquat inhibit Bungarus sindanus (krait) venom acetylcholinesterase and human serum butyrylcholinesterase in vitro
    Mushtaq Ahmed
    Departmento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
    Ecotoxicology 16:363-9. 2007
    ..a world widely used herbicide, were tested on acetylcholinesterase (AChE) from Bungarus sindanus venom and butyrylcholinesterase (BChE) from human serum...
  40. doi Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun
    Eugenie Carletti
    Unite d Enzymologie, Departement de Toxicologie, Centre de Recherches du Service de Santé des Armées CRSSA, 24 av des Maquis du Grésivaudan, 38700 La Tronche, France
    Biochem J 421:97-106. 2009
    hBChE [human BChE (butyrylcholinesterase)] naturally scavenges OPs (organophosphates). This bioscavenger is currently in Clinical Phase I for pretreatment of OP intoxication...
  41. doi Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase
    Maja Katalinić
    Institute for Medical Research and Occupational Health, Ksaverska cesta 2, HR 10000 Zagreb, Croatia
    Eur J Med Chem 45:186-92. 2010
    ..kaempferol, quercetin, myricetin, fisetin, apigenin, luteolin and rutin, reversibly inhibited human butyrylcholinesterase (BChE, EC 3.1.1.8). Inhibition potency of the flavonoids we attributed to their chemical structure, i.e...
  42. ncbi DNA sequence of butyrylcholinesterase from the rat: expression of the protein and characterization of the properties of rat butyrylcholinesterase
    Andreea Ticu Boeck
    Eppley Institute, 986805, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Biochem Pharmacol 63:2101-10. 2002
    The rat is the model animal for toxicity studies. Butyrylcholinesterase (BChE), being sensitive to inhibition by some organophosphorus and carbamate pesticides, is a biomarker of toxic exposure...
  43. doi Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis
    N Aurbek
    Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany
    Toxicology 259:133-9. 2009
    ..However, measurement of erythrocyte AChE is not standard practice. In contrast, determination of plasma butyrylcholinesterase (BChE) activity is in routine use for monitoring the benefit of oxime therapy...
  44. ncbi L-lactate reduces in vitro the inhibition of butyrylcholinesterase (BChE) by paraoxon (E 600)
    G Petroianu
    University of Heidelberg at Mannheim, Department of Pharmacology and Toxicology, Mannheim, Germany
    J Appl Toxicol 19:329-36. 1999
    ..In vitro effects of lactate on the inhibition of butyrylcholinesterase (BChE) by POX were assessed in plasma of 12 healthy human volunteers...
  45. ncbi Pesticides and susceptible populations: people with butyrylcholinesterase genetic variants may be at risk
    O Lockridge
    University of Nebraska Medical Center, Eppley Institute, Omaha 68198 6805, USA
    Neurotoxicology 21:113-26. 2000
    b>Butyrylcholinesterase (BChE) scavenges low doses of organophosphorus (for example, paraoxon) and carbamate pesticides (for example, carbaryl) and in this way protects people from the toxic effects of these poisons...
  46. doi Effect of polyethylene glycol modification on the circulatory stability and immunogenicity of recombinant human butyrylcholinesterase
    Nageswararao Chilukuri
    Division of Biochemistry, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Chem Biol Interact 175:255-60. 2008
    The therapeutic value of human serum butyrylcholinesterase (Hu BChE) as a bioscavenger of chemical warfare agents is due to its high reactivity with organophosphorus compounds and prolonged circulatory stability...
  47. ncbi Production of the butyrylcholinesterase knockout mouse
    Bin Li
    University of Nebraska Medical Center, Eppley Institute, Omaha, NE 68198 6805, USA
    J Mol Neurosci 30:193-5. 2006
    The butyrylcholinesterase (BChE [EC 3.1.1.8]) knockout mouse is a model for BChE deficiency in humans...
  48. ncbi Butyrylcholinesterase and the control of synaptic responses in acetylcholinesterase knockout mice
    Emmanuelle Girard
    CNRS, Institut de Neurobiologie Alfred Fessard, FRC2118, Laboratoire de Neurobiologie Cellulaire et Moleculaire, UPR 9040, 1, Avenue de la Terrasse, Gif sur Yvette, F 91198, France
    Life Sci 80:2380-5. 2007
    At the neuromuscular junction (NMJ) acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) can hydrolyze acetylcholine (ACh)...
  49. doi Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum
    He Li
    Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Appl Toxicol 29:149-55. 2009
    Carbofuran is a pesticide whose acute toxicity is due to inhibition of acetylcholinesterase. Butyrylcholinesterase (BChE) in plasma is inhibited by carbofuran and serves as a biomarker of poisoning by carbofuran...
  50. doi High-level expression of functional recombinant human butyrylcholinesterase in silkworm larvae by Bac-to-Bac system
    Shuo Li
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    Chem Biol Interact 187:101-5. 2010
    b>Butyrylcholinesterase (BChE: EC 3.1.1.8) serves as a natural scavenger for a variety of drugs, poisons, and organophosphorous compounds by hydrolyzing their ester bonds...
  51. doi Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX
    Ashima Saxena
    Division of Biochemistry, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Biochem Pharmacol 81:164-9. 2011
    Human serum butyrylcholinesterase (Hu BChE) is currently under advanced development as a bioscavenger for the prophylaxis of organophosphorus (OP) nerve agent toxicity in humans...
  52. ncbi Resistance of butyrylcholinesterase to inactivation by ultrasound: effects of ultrasound on catalytic activity and subunit association
    M T Froment
    Centre de Recherches du Service de Sante des Armees, Unite d Enzymologie, BP 87, 38702 La Tronche Cedex, France
    Biochim Biophys Acta 1387:53-64. 1998
    The effects of 20 kHz ultrasound on catalytic activity and structure of the tetramer of wild-type human butyrylcholinesterase (BChE) from plasma and recombinant D70G mutant enzyme were studied at constant temperature...
  53. ncbi Carboxylic esterase and its associations with long-term effects of organophosphorus pesticides
    Zhi jun Zhou
    Dept of Occupational Health and Toxicology, School of Public Health, WHO Collaborating Center for Occupational Health Key Laboratory of Public Health and Safety, Ministry of Education, Fudan University, Shanghai 200032, China
    Biomed Environ Sci 20:284-90. 2007
    To examine a) the effect of organophosphorus pesticide exposure on activity of carboxylic esterases, namely butyrylcholinesterase (BChE), carboxylesterase (CarbE) and paraoxonase (PonE); and b) the association of polymorphisms of BChE ..
  54. ncbi Essential amino acids for the stability of human butyrylcholinesterase as predicted by CUPSAT server
    Biju Thomas
    Department of Biotechnology, School of Biotechnology and Genetic Engineering, Bharathiar University, Coimbatore, Tamilnadu, 641046, India
    In Silico Biol 8:517-29. 2008
    Although butyrylcholinesterase (BChE) is ubiquitous in the human system, its physiological function has often been questioned. Yet BChE has been the subject of active research since its discovery six decades ago...
  55. ncbi Acetylcholinesterase and butyrylcholinesterase activities in brain and plasma of freshwater teleosts: cross-species and cross-family differences
    G M Chuiko
    Institute of the Biology of Inland Waters IBIW, Russian Academy of Sciences, 152742, Borok, Yaroslavl, Russia
    Comp Biochem Physiol B Biochem Mol Biol 135:55-61. 2003
    Brain and plasma acetylcholinesterase (AChE; EC 3.1.1.7) and plasma butyrylcholinesterase (BChE; EC 3.1.1...
  56. ncbi Hysteresis of butyrylcholinesterase in the approach to steady-state kinetics
    Patrick Masson
    Centre de Recherches du Service de Sante des Armees, BP 87, 38702 La Tronche Cedex, France
    Chem Biol Interact 157:143-52. 2005
    b>Butyrylcholinesterase (BChE) displays hysteretic behavior with certain neutral and charged substrates in the approach to steady state...
  57. doi Efficacy of human serum butyrylcholinesterase against sarin vapor
    Ashima Saxena
    Division of Biochemistry, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Chem Biol Interact 175:267-72. 2008
    Human serum butyrylcholinesterase (Hu BChE) is currently under advanced development as a pretreatment drug for organophosphate (OP) poisoning in humans...
  58. doi Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents
    Nageswararao Chilukuri
    Department of Molecular Pharmacology, Division of Biochemistry, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Mol Pharmacol 76:612-7. 2009
    Human serum butyrylcholinesterase (Hu BChE) is a promising therapeutic against the toxicity of chemical warfare nerve agents...
  59. ncbi Reduced acetylcholine receptor density, morphological remodeling, and butyrylcholinesterase activity can sustain muscle function in acetylcholinesterase knockout mice
    Michael Adler
    Neurotoxicology Branch, Pharmacology Division, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010, USA
    Muscle Nerve 30:317-27. 2004
    ..The AChE-/- mice fail to express AChE but have normal levels of butyrylcholinesterase (BChE) and can survive into adulthood...
  60. doi Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase
    Ellen G Duysen
    University of Nebraska Medical Center, Eppley Institute, Omaha, NE 68198 6805, USA
    Chem Biol Interact 175:119-24. 2008
    b>Butyrylcholinesterase (BChE) has proven to be an effective bioscavenger against nerve agents and organophosphates...
  61. doi Increased hepatotoxicity and cardiac fibrosis in cocaine-treated butyrylcholinesterase knockout mice
    Ellen G Duysen
    Eppley Institute, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Basic Clin Pharmacol Toxicol 103:514-21. 2008
    In mice, cocaine is detoxified to inactive products by butyrylcholinesterase (BChE) and carboxylesterase. In human beings, cocaine detoxification is primarily by BChE...
  62. ncbi The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease
    Ellen G Duysen
    Researcher Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Expert Opin Drug Metab Toxicol 5:523-8. 2009
    b>Butyrylcholinesterase (BChE) mutations common in the human population may result in complete or partial BChE deficiency, making the BChE knockout (KO) mouse a model for human deficiencies...
  63. pmc Intrathecal delivery of fluorescent labeled butyrylcholinesterase to the brains of butyrylcholinesterase knock-out mice: visualization and quantification of enzyme distribution in the brain
    Noel D Johnson
    Division of Comparative Medicine, University of Nebraska Medical Center, Omaha, NE 68198, United States
    Neurotoxicology 30:386-92. 2009
    Exogenously delivered butyrylcholinesterase (BChE) has proven to be an efficient bioscavenger against highly toxic organophosphorus poisons and nerve agents...
  64. pmc Localization of butyrylcholinesterase at the neuromuscular junction of normal and acetylcholinesterase knockout mice
    Brigitte Blondet
    Laboratoire CRRET, Universite Paris Est, EAC CNRS 7149, 61 Avenue du General de Gaulle, 94010 Creteil, France
    J Histochem Cytochem 58:1075-82. 2010
    ..junction (NMJ), there are two distinct cholinesterases (ChE): acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Until now, it has been difficult to determine the precise localization of BChE at the NMJ...
  65. doi Adenovirus-mediated gene transfer of human butyrylcholinesterase results in persistent high-level transgene expression in vivo
    Nageswararao Chilukuri
    Division of Biochemistry, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Chem Biol Interact 175:327-31. 2008
    Human serum butyrylcholinesterase (Hu BChE) is a promising therapeutic against the toxicity of chemical warfare nerve agents, pesticide intoxication, and cocaine overdose...
  66. ncbi Aryl acylamidase activity exhibited by butyrylcholinesterase is higher in chick than in horse, but much lower than in fetal calf serum
    E Weitnauer
    Department of Developmental Biology and Neurogenetics, Institute for Zoology, Darmstadt University of Technology, Darmstadt, Germany
    Neurosci Lett 254:153-6. 1998
    Several side activities have been attributed to butyrylcholinesterase (BChE), including aryl acylamidase (AAA) activity, which is an amidase-like activity with unknown physiological function splitting the artificial substrate o-..
  67. ncbi Differences in active-site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase
    A Saxena
    Division of Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307, USA
    Chem Biol Interact 119:61-9. 1999
    ..examined the role of A328(F330) in the binding of various inhibitors to cholinesterases (ChEs) using human butyrylcholinesterase (BChE) mutants to determine if the conclusions drawn from studies with acetylcholinesterase (AChE) mutants ..
  68. ncbi Polyethylene glycosylation prolongs the circulatory stability of recombinant human butyrylcholinesterase
    N Chilukuri
    Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Chem Biol Interact 157:115-21. 2005
    ..study, we explored the use of the newly designed AdenoVATOR system for the expression of recombinant human butyrylcholinesterase (rHu BChE) in human embryonic kidney 293A (HEK-293A) cells...
  69. pmc Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin
    Yue Jin Huang
    PharmAthene Canada Inc, formally Nexia Biotechnologies Inc, 7150 Alexander Fleming, Montreal, QC H4S 2C8, Canada
    BMC Biotechnol 8:50. 2008
    Human butyrylcholinesterase (huBChE) has been shown to be an effective antidote against multiple LD50 of organophosphorus compounds. A prerequisite for such use of huBChE is a prolonged circulatory half-life...
  70. ncbi Paraoxonase 1 correlates with butyrylcholinesterase and gamma glutamyl transferase in workers chronically exposed to pesticides
    Manel Araoud
    Laboratory of Biochemistry 05 UR 09 09, Faculty of Medicine of Monastir, Monastir, Tunisia
    J Occup Health 52:383-8. 2010
    ..The aims of this study were to ascertain the relationships between paraoxonase 1 (PON1) and other serum enzymes and to investigate whether long-term exposure to pesticides affects these relationships in Tunisian agricultural workers...
  71. ncbi Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma
    C F Bartels
    Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Biochem Pharmacol 60:479-87. 2000
    Cat serum contains 0.5 mg/L of butyrylcholinesterase (BChE, EC 3.1.1. 8) and 0.3 mg/L of acetylcholinesterase (AChE, EC 3.1.1.7); this can be compared with 5 mg/mL and < 0.01 mg/L, respectively, in human serum...
  72. ncbi Development of a MALDI-TOF-MS method to identify and quantify butyrylcholinesterase inhibition resulting from exposure to organophosphate and carbamate pesticides
    Jinchun Sun
    Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506 0286, USA
    J Am Soc Mass Spectrom 18:698-706. 2007
    ..proteomics based method was developed for the detection, quantification, and categorization of serum butyrylcholinesterase (BChE) inhibitors, including organophosphates (OPs) and carbamates (CBs)...
  73. ncbi Butyrylcholinesterase K variant and cerebral amyloid angiopathy
    M Yamada
    Department of Neurology, Tokyo Medical and Dental University, Tokyo, Japan
    Stroke 29:2488-90. 1998
    ..A gene for the K variant of butyrylcholinesterase (BCHE-K) may be associated with late-onset Alzheimer's disease (AD)...
  74. ncbi Sensorimotor deficit and cholinergic changes following coexposure with pyridostigmine bromide and sarin in rats
    Mohamed B Abou-Donia
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Toxicol Sci 66:148-58. 2002
    ..By 15 days following sarin treatment, plasma butyrylcholinesterase (BChE) activity returned to normal levels in the animals treated with sarin alone, whereas in the animals ..
  75. pmc Acetylcholinesterase active centre and gorge conformations analysed by combinatorial mutations and enantiomeric phosphonates
    Zrinka Kovarik
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093 0636, USA
    Biochem J 373:33-40. 2003
    ..1.1.7), with substitutions corresponding to residues found largely within the butyrylcholinesterase (BChE; EC 3.1.1...
  76. ncbi Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants
    I Orhan
    Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey
    J Ethnopharmacol 91:57-60. 2004
    ..Fumariaceae) were screened for their anticholinesterase activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes by in vitro Ellman method at 10 microg/ml and 1 mg/ml concentrations...
  77. ncbi Physicochemical and biological data for the development of predictive organophosphorus pesticide QSARs and PBPK/PD models for human risk assessment
    James B Knaak
    Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, SUNY at Buffalo, Buffalo, New York 14214, USA
    Crit Rev Toxicol 34:143-207. 2004
    ..A limited amount of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carboxylesterase (CaE) inhibition and recovery data were found in the literature on the 31 OPs...
  78. ncbi The k variant of the butyrylcholinesterase gene is associated with reduced phosphorylation of tau in dementia patients
    Clive Ballard
    Wolfson Centre for Age Related Diseases, Guys Campus, Kings College London, London, UK
    Dement Geriatr Cogn Disord 19:357-60. 2005
    Accumulating evidence suggests that butyrylcholinesterase (BuChE) plays an important role in the progression of cognitive deficits and Alzheimer-type pathology in dementia patients...
  79. doi Comparing the relative toxicity of malathion and malaoxon in blue catfish Ictalurus furcatus
    Winfred G Aker
    Department of Biology, Jackson State University, PO Box 18540, Jackson, Mississippi 39217, USA
    Environ Toxicol 23:548-54. 2008
    ..Moreover, malaoxon showed significant inhibition on butyrylcholinesterase (BChE) in the liver if the concentrations were increased to more than 1 ppm...
  80. doi Esterases activities and lipid peroxidation levels in muscle tissue of the shanny Lipophrys pholis along several sites from the Portuguese Coast
    Montserrat Sole
    Institut de Ciències del Mar ICM CSIC, Pg Maritim de la Barceloneta 37 49, 08003 Barcelona, Spain
    Mar Pollut Bull 56:999-1007. 2008
    ..The inclusion of a marker of effect, measured as lipid peroxidation levels in muscle tissue, also revealed the existence of site differences. Overall, the study further validates the utility of L. pholis in pollution monitoring studies...
  81. doi Long-term effects of human butyrylcholinesterase pretreatment followed by acute soman challenge in cynomolgus monkeys
    Wei Sun
    Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Chem Biol Interact 175:428-30. 2008
    Human serum butyrylcholinesterase (Hu BChE) was demonstrated previously to be an effective prophylaxis that can protect animals from organophosphate nerve agents...
  82. doi Differential mRNA expression of acetylcholinesterase in the central nervous system of rats with acute and chronic exposure of sarin & physostigmine
    Iti Bansal
    Defence Research and Development Establishment, Defence Research and Development Organization, Gwalior, India
    J Appl Toxicol 29:386-94. 2009
    ..These observations further suggest that route of administration as well as dose exposure regimen also contributes to the regulation of AChE mRNA expression...
  83. doi Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications
    Kamil Musilek
    Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic
    Bioorg Med Chem Lett 20:1763-6. 2010
    ..The newly prepared compounds were evaluated in vitro on human erythrocyte AChE and human plasmatic butyrylcholinesterase (BChE). Their inhibitory ability was expressed as IC(50) and compared to standard carbamate drugs...
  84. doi Butyrylcholinesterase activity in women with diabetes mellitus in pregnancy: correlation with antioxidant activity
    A E Omu
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    J Obstet Gynaecol 30:122-6. 2010
    ..pregnancies and 15 non-pregnant healthy controls were investigated to evaluate the relationship between butyrylcholinesterase activity and antioxidant status in the serum and placenta of diabetic pregnant women...
  85. doi Regulation of flagellar, motility and chemotaxis genes in Rhizobium leguminosarum by the VisN/R-Rem cascade
    Dinah D Tambalo
    Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada
    Microbiology 156:1673-85. 2010
    ..the expression of rem, while Rem positively regulates the expression of flaA, flaB, flaC, flaD, motA, motB, che1 and mcpD. All of these genes except mcpD are located within the main motility and chemotaxis gene cluster of R...
  86. doi Pseudo-catalytic scavenging: searching for a suitable reactivator of phosphorylated butyrylcholinesterase
    Zrinka Kovarik
    Institute for Medical Research and Occupational Health, POB 291, HR 10001 Zagreb, Croatia
    Chem Biol Interact 187:167-71. 2010
    b>Butyrylcholinesterase is considered to be an endogenous stoichiometric bioscavenger of organophosphorus compounds (OPs), but due to limited concentration of BChE in the organism, stoichiometric reduction of OP is not always sufficient...
  87. doi Demonstration of in vivo stability and lack of immunogenicity of a polyethyleneglycol-conjugated recombinant CHO-derived butyrylcholinesterase bioscavenger using a homologous macaque model
    YVONNE J ROSENBERG
    PlantVax Inc, Suite 120, 9430 Key West Avenue, Rockville, MD 20850 6350, USA
    Chem Biol Interact 187:279-86. 2010
    Human serum and recombinant butyrylcholinesterase (rHuBChE) are the most advanced prophylactics against organophosphate (OP) toxicity due to nerve agent or insecticide exposure...
  88. pmc Identification and characterization of biomarkers of organophosphorus exposures in humans
    Jerry H Kim
    Department of Anesthesiology, University of Washington, Seattle, WA, USA
    Adv Exp Med Biol 660:61-71. 2010
    ..The aim of our work has been to identify, purify, and characterize new biomarkers of OP exposure. Butyrylcholinesterase (BChE) inhibition has been a standard for monitoring OP exposure...
  89. doi Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors
    Leonardo Pisani
    Dipartimento Farmaco Chimico, Università degli Studi di Bari Aldo Moro, Via Orabona 4, 70125 Bari, Italy
    ChemMedChem 5:1616-30. 2010
    ..moieties were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors...
  90. doi Counter-regulation of cholinesterases: differential activation of PKC and ERK signaling in retinal cells through BChE knockdown
    Ebru Bodur
    Hacettepe University, Faculty of Medicine, Department of Biochemistry, Sihhiye, Ankara, Turkey
    Biochimie 93:469-76. 2011
    ..Through application of siRNAs against butyrylcholinesterase (BChE) in R28 cells, a retinal cell line with pluripotent properties, a counter-regulation between ChEs ..
  91. doi Salvia leriifolia Benth (Lamiaceae) extract demonstrates in vitro antioxidant properties and cholinesterase inhibitory activity
    Monica R Loizzo
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Health Sciences and Nutrition, University of Calabria, I 87036 Rende CS, Italy
    Nutr Res 30:823-30. 2010
    ..activity using the modified colorimetric Ellman's method against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)...
  92. pmc Biochemical and genetic analysis of butyrylcholinesterase (BChE) in a family, due to prolonged neuromuscular blockade after the use of succinylcholine
    Daniel Fantozzi Garcia
    Hospital das Clinicas, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    Genet Mol Biol 34:40-4. 2011
    b>Butyrylcholinesterase (BChE) is a plasma enzyme that catalyzes the hydrolysis of choline esters, including the muscle-relaxant succinylcholine and mivacurium...
  93. doi Isatin-3-N4-benzilthiosemicarbazone, a non-toxic thiosemicarbazone derivative, protects and reactivates rat and human cholinesterases inhibited by methamidophos in vitro and in silico
    Rômulo Pillon Barcelos
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Campus UFSM, 97105 900 Santa Maria, RS, Brazil
    Toxicol In Vitro 26:1030-9. 2012
    Organophosphates (OPs), which are widely used as pesticides, are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors...
  94. pmc Probing the peripheral site of human butyrylcholinesterase
    Ian R Macdonald
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Biochemistry 51:7046-53. 2012
    Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) catalyze the hydrolysis of the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission...
  95. ncbi Capsofulvesins A-C, cholinesterase inhibitors from Capsosiphon fulvescens
    Zhe Fang
    College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712 702, Republic of Korea
    Chem Pharm Bull (Tokyo) 60:1351-8. 2012
    ..90 to 82.83 µM, whereas 2-6 showed butyrylcholinesterase (BChE) inhibitory activities with IC(50) values of 114.75-185.55 µM...
  96. doi Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase
    Marco Catto
    Dipartimento di Farmacia, Università degli Studi di Bari Aldo Moro, Via E Orabona 4, Bari 70125, Italy
    Bioorg Med Chem 21:146-52. 2013
    ..in AD therapy, acting as a dual binding site, reversible inhibitor of AChE with high selectivity over butyrylcholinesterase (BChE)...
  97. pmc Aspirin hydrolysis in plasma is a variable function of butyrylcholinesterase and platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)
    Gang Zhou
    Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    J Biol Chem 288:11940-8. 2013
    ..association study of 2054 GeneBank subjects identified a single locus immediately adjacent to the BCHE (butyrylcholinesterase) gene associated with plasma aspirin hydrolytic activity (lead SNP, rs6445035; p = 9.1 × 10(-17))...
  98. doi Cholinesterase inhibitory activity versus aromatic core multiplicity: a facile green synthesis and molecular docking study of novel piperidone embedded thiazolopyrimidines
    Alireza Basiri
    School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia
    Bioorg Med Chem 22:906-16. 2014
    ..cascade methodology in ionic liquid and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities...
  99. doi 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies
    Ornella Di Pietro
    Laboratori de Química Farmacèutica Unitat Associada al CSIC, Facultat de Farmacia, and Institut de Biomedicina IBUB, Universitat de Barcelona, Av Joan XXIII 27 31, E 08028 Barcelona, Spain
    Eur J Med Chem 73:141-52. 2014
    ..tested against Electrophorus electricus AChE (EeAChE), human recombinant AChE (hAChE), and human serum butyrylcholinesterase (hBChE), and their brain penetration has been assessed using the PAMPA-BBB assay...
  100. doi Diethyl 2-(phenylcarbamoyl)phenyl phosphorothioates: synthesis, antimycobacterial activity and cholinesterase inhibition
    Jarmila Vinsova
    Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
    Molecules 19:7152-68. 2014
    ..Prepared thiophosphates were also evaluated against acetylcholinesterase from electric eel and butyrylcholinesterase from equine serum...
  101. pmc Photography by Cameras Integrated in Smartphones as a Tool for Analytical Chemistry Represented by an Butyrylcholinesterase Activity Assay
    Miroslav Pohanka
    Faculty of Military Health Sciences, University of Defense, Trebesska 1575, Hradec Kralove CZ 50001, Czech Republic
    Sensors (Basel) 15:13752-62. 2015
    ..e., the determination of a biochemical marker butyrylcholinesterase (BChE). The work should demonstrate suitability of a smartphone-integrated camera for analytical purposes...

Research Grants28

  1. Enhanced bioscavenger for medical countermeasures against organophosphorus agents
    Zhiguo Zhou; Fiscal Year: 2013
    ..the most promising strategy to counter OP intoxication is to scavenge the agents using recombinant butyrylcholinesterase (rBChE), the major cholinesterase in human which has low substrate specificity and thus offers broad ..
  2. A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide Neurotoxicity
    Yvonne Rosenberg; Fiscal Year: 2007
    ..of the targeted acetylcholinesterase (AChE) by OP insecticides may be prevented by high levels of serum butyrylcholinesterase (BChE) which is a potent bioscavenger and detoxicant of OP...
  3. Central cholinergic function in AChE-deficient mice
    Jochen Klein; Fiscal Year: 2006
    ..b>Butyrylcholinesterase (BChE), an enzyme associated with glial cells in the brain but of unknown function, is known to hydrolyze ..
  4. Optimization of nonpyridinium oximes for BChE hydrolysis of OPs in plasma
    PALMER WILLIAM TAYLOR; Fiscal Year: 2012
    ..provided by applicant): The principal aim of this study is to optimize the efficient and affordable butyrylcholinesterase (BChE) based catalytic scavenger system developed in vitro for treatment of acute organophosphate (OP) ..
  5. Aerosol Delivery of a Recombinant Butyrylcholinesterase "BioShield" to Protect Ag
    YVONNE J ROSENBERG; Fiscal Year: 2012
    ..m. The aim of this project is to butyrylcholinesterase as an aerosol in a pulmonary delivery device to that it deposits in the lung and forms a "bioshield" and ..
  6. YVONNE J ROSENBERG; Fiscal Year: 2015
    ....
  7. WILLIAM STEPHEN BRIMIJOIN; Fiscal Year: 2014
    ..approach that will be taken utilizes gene transfer vectors to deliver a mutated version of human plasma butyrylcholinesterase (BChE), which efficiently hydrolyzes cocaine into metabolites that are largely devoid of toxicity and ..
  8. Chang Guo Zhan; Fiscal Year: 2015
    ..Enhancing cocaine metabolism by administration of human butyrylcholinesterase (BChE) is recognized as an efficient treatment strategy for cocaine overdose and addiction...
  9. Chang Guo Zhan; Fiscal Year: 2015
    ..There is still no FDA-approved anti-cocaine medication. Enhancing cocaine metabolism by administration of butyrylcholinesterase (BChE) has been recognized as a promising treatment strategy for cocaine abuse...
  10. EVALUATION OF PROTEIN BASED MEDICATIONS AGAINST COCAINE
    James Woods; Fiscal Year: 2003
    ..A fourth medication is butyrylcholinesterase, the enzyme that breaks down cocaine in the blood...
  11. SUPRAMOLECULAR A/BETA--GLIAL INTERACTIONS & CELL RESPONS
    Linda Van Eldik; Fiscal Year: 1999
    ..and activity of six relevant glial proteins: a 1-antichymotrypsin (ACT), apolipoprotein E (apoE), apoJ, butyrylcholinesterase (BChE), interleukin-1 (IL-1), and S100 beta ...
  12. The Impact of Genetic Variability on Human Susceptibility to Chlorpyrifos
    ALICE LANGFORD CRANE; Fiscal Year: 2013
    ..CPF-O is a potent cholinesterase (ChE) inhibitor...
  13. Zoran Radic; Fiscal Year: 2014
    ..level where oral or parenteral oximes directed to reactivating BChE are efficacious without having to resort to the cumbersome and risk- associated BChE fortification of activity in field and non-sterile conditions? ..
  14. Genetic Profiles for Perioperative Applications
    ROBERT KWIATKOWSKI; Fiscal Year: 2001
    ..abstract_text> ..
  15. Genes, OP Pesticides, and Reproductive Health
    Scott Venners; Fiscal Year: 2007
    ..Venners will investigate SNPs included in the NIEHS GeneSNP database as well as others identified from the literature. A total of 1000 husband-wife pairs (2000 subjects) will be genotyped using PCR-OLA/PCR-RFLP assays. ..
  16. BCHE as a Cocaine Antagonist
    James Woods; Fiscal Year: 2002
    ..The possibility that human BChE can eventually be used as a safe and effective treatment of cocaine abuse and toxicity is being explored through these studies. ..
  17. Acetylcholinesterase: A Comparative Biochemical Approach
    Leo Pezzementi; Fiscal Year: 2005
    ..gene duplication early in vertebrate evolution, humans and other vertebrates have another cholinesterase, butyrylcholinesterase, which appears to act as a scavenger of a variety of toxins in the body...
  18. Redesign of Butyrylcholinesterase for Cocaine Metabolism
    Chang Guo Zhan; Fiscal Year: 2010
    This project focuses on the rational redesign of human butyrylcholinesterase (BChE) in order to accelerate cocaine metabolism in human...
  19. Mass Spectrometry in Clinical Diagnosis of Nerve Agent Exposure
    Oksana Lockridge; Fiscal Year: 2008
    ..Two proteins in blood, butyrylcholinesterase and albumin, will be tested as biomarkers of nerve agent exposure in our new assays...
  20. Mechanistic Studies of Lipoic Acid Synthase
    Squire J Booker; Fiscal Year: 2010
    ..There is significant evidence that lipoic acid can be endogenously synthesized in mammalian cells, and that the inhibition of this pathway compromises cellular function and leads to death. ..
  21. Genetic evaluation of nitric oxide regulating genes in ischemic stroke
    Timothy Howard; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. Genetic analysis of organophosphate metabolism in NC farmworkers
    Timothy Howard; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. Statistical Methods for Admixture Mapping
    Shuanglin Zhang; Fiscal Year: 2007
    ..abstract_text> ..
  24. Statistical Methods for Mapping Complex Disease Genes
    Shuanglin Zhang; Fiscal Year: 2007
    ..The proposed methodology will be implemented by user-friendly software. The documentation, distribution, and support of the software will be provided. ..
  25. Structural Basis of Novel Hookworm Vaccines
    Oluwatoyin Asojo; Fiscal Year: 2006
    ..56 Angstroms (protein data bank code 1U53). In addition, a 2 PR-1 domain ASP (Na-ASP-1) has been crystallized with data up to 2.7 Angstroms. [unreadable] [unreadable] [unreadable]..
  26. CANCER RESEARCH TRAINING IN NUCLEAR MEDICINE
    David Kuhl; Fiscal Year: 2003
    ..The combination of faculty motivation, structured curricula, excellent facilities, and superb intellectual environment is expected to prepare individuals to be tomorrow's leaders in cancer research. ..
  27. Positron Tomograph for Preclinical Research
    David Kuhl; Fiscal Year: 2002
    ..g.: some experimental lesion models, gene transfection studies, etc.) Or where there is considerable investment in the animals (e.g. primate studies). ..
  28. EMISSION COMPUTED TOMOGRAPHY OF LOCAL CEREBRAL FUNCTION
    David Kuhl; Fiscal Year: 2001
    ..Such information could facilitate new pharmacologic classifications of patients, better matches of patients to therapies, more rational pathways to new drugs, and guides to new therapies and strategies for neuroprotection. ..