BRSK1

Summary

Gene Symbol: BRSK1
Description: BR serine/threonine kinase 1
Alias: hSAD1, serine/threonine-protein kinase BRSK1, BR serine/threonine-protein kinase 1, SAD1 homolog, SAD1 kinase, SadB kinase short isoform, brain-selective kinase 1, brain-specific serine/threonine-protein kinase 1, protein kinase SAD1A, serine/threonine-protein kinase SAD-B, synapses of Amphids Defective homolog 1
Species: human

Top Publications

  1. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
  2. ncbi SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release
    Eiji Inoue
    KAN Research Institute, Kyoto 600 8815, Japan
    Neuron 50:261-75. 2006
  3. ncbi Putative Tumor Suppressor Genes EGR1 and BRSK1 Are Mutated in Gastric and Colorectal Cancers
    Eun Ji Choi
    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Oncology 91:289-294. 2016
  4. pmc Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells
    Jia Nie
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing 210029, China
    J Biol Chem 287:26435-44. 2012
  5. doi Phosphorylation of microtubule-associated protein tau by AMPK-related kinases
    Hirotaka Yoshida
    MRC Laboratory of Molecular Biology, Cambridge, UK
    J Neurochem 120:165-76. 2012
  6. doi Ethnic specificity of variants of the ESR1, HK3, BRSK1 genes and the 8q22.3 locus: no association with premature ovarian failure (POF) in Serbian women
    Yingying Qin
    Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China
    Maturitas 77:64-7. 2014
  7. pmc Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity
    Vanessa P Houde
    MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U K
    Biochem J 458:41-56. 2014
  8. pmc Meta-analysis of loci associated with age at natural menopause in African-American women
    Christina T L Chen
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 23:3327-42. 2014
  9. pmc Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming
    Amit Choudhary
    Society of Fellows, Harvard University, Cambridge, Massachusetts, United States of America Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, United States of America
    PLoS ONE 9:e95194. 2014
  10. ncbi 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK
    Abdallah K Al-Hakim
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 118:5661-73. 2005

Research Grants

  1. Laurie J Goodyear; Fiscal Year: 2016

Scientific Experts

  • Christina T L Chen
  • R Pieters
  • Maria Alvarado-Kristensson
  • Nicholas C M Hearle
  • Abdallah K Al-Hakim
  • Chunyan He
  • Laurie J Goodyear
  • Yingying Qin
  • Sarah Fogarty
  • D Grahame Hardie
  • Eun Ji Choi
  • Jose M Lizcano
  • Vanessa P Houde
  • Amit Choudhary
  • Hua Wang
  • XiangLan Sun
  • W van Dorp
  • Chong Shen
  • Kylee L Spencer
  • C L Carty
  • Martin Voss
  • Zi Jiang Chen
  • Hirotaka Yoshida
  • Jia Nie
  • Arantza Rodríguez-Asiain
  • Dario R Alessi
  • Lisette Stolk
  • N J Bright
  • Nicola J Bright
  • Simon A Hawley
  • Eiji Inoue
  • Rui Lu
  • Min Sung Kim
  • Sug Hyung Lee
  • Nam Jin Yoo
  • Chang Hyeok An
  • Stefan Kubicek
  • Jun Fei Xu
  • Xiao Bing Liu
  • Qing qing Wang
  • Natalia Shpiro
  • Joe Leigh Simpson
  • Paul Davies
  • Miomira Ivović
  • Robert Gourlay
  • Stuart L Schreiber
  • Farook Al-Azzawi
  • Dina Fomina-Yadlin
  • Bridget K Wagner
  • Maja Ivanisević
  • Chen yi Sheng
  • Paul A Clemons
  • Jia Hui Chen
  • Raymond Dalgleish
  • Namrata D Udeshi
  • Jin Li
  • Milina Tancić
  • Qi chao Ni
  • Vlado Dancik
  • Guangyu Li
  • Joby Varghese
  • Steven A Carr
  • Jin Peng Chen
  • Svetlana Vujovic
  • Philipp Mertins
  • Kei Sakamoto
  • Kaihui Hu He
  • Maria Stella Ritorto
  • N Franceschini
  • R Goodloe
  • T C Matise
  • K Brown-Gentry
  • Dana C Crawford
  • L A Hindorff
  • Yong Bing Xiang
  • Jiajun Zhao
  • Patricia T W Cohen
  • B Henderson
  • C A Haiman
  • A G Uitterlinden
  • Aleksandar Rajkovic
  • Nora Franceschini
  • Iona Cheng
  • Christopher S Carlson
  • Ryan J Delahanty
  • U Peters
  • V W Setiawan
  • J Malinowski
  • S Buyske
  • Cristina Martin-Granados

Detail Information

Publications30

  1. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
    ..A total of 12 human kinases (NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) are related to AMPK...
  2. ncbi SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release
    Eiji Inoue
    KAN Research Institute, Kyoto 600 8815, Japan
    Neuron 50:261-75. 2006
    ..Furthermore, SAD-B phosphorylates the active zone protein RIM1 but not Munc13-1. These results suggest that mammalian SAD kinase presynaptically regulates neurotransmitter release...
  3. ncbi Putative Tumor Suppressor Genes EGR1 and BRSK1 Are Mutated in Gastric and Colorectal Cancers
    Eun Ji Choi
    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Oncology 91:289-294. 2016
    The transcription factor-encoding EGR1 and the kinase-encoding BRSK1 are considered putative tumor suppressor genes (TSGs)...
  4. pmc Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells
    Jia Nie
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing 210029, China
    J Biol Chem 287:26435-44. 2012
    ..Together, the present studies identified a critical role of SAD-A in the activation of PAK1 during the onset of insulin exocytosis...
  5. doi Phosphorylation of microtubule-associated protein tau by AMPK-related kinases
    Hirotaka Yoshida
    MRC Laboratory of Molecular Biology, Cambridge, UK
    J Neurochem 120:165-76. 2012
    ..BX 795, an inhibitor of MARK1 and SIK, reduced 12E8-immunolabelling of tau in rat cortical neurons. These findings reveal a significant contribution of AMPK-related kinases to the phosphorylation of tau at S262/S356...
  6. doi Ethnic specificity of variants of the ESR1, HK3, BRSK1 genes and the 8q22.3 locus: no association with premature ovarian failure (POF) in Serbian women
    Yingying Qin
    Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China
    Maturitas 77:64-7. 2014
    ..3 SNPs rs3847153 and rs3108910; and one SNP each in HK3 (rs2278493), ESR1 (rs2234693) and BRSK1 (rs12611091) - are associated with premature ovarian failure (POF) in a different ethnic group (Serbian).
  7. pmc Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity
    Vanessa P Houde
    MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U K
    Biochem J 458:41-56. 2014
    ..The activity of several of the AMPK-related kinases analysed [BRSK1 (BR serine/threonine kinase 1), BRSK2, NUAK1 (NUAK family, SNF1-like kinase 1), SIK3 (salt-inducible kinase 3) and ..
  8. pmc Meta-analysis of loci associated with age at natural menopause in African-American women
    Christina T L Chen
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 23:3327-42. 2014
    ..05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports...
  9. pmc Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming
    Amit Choudhary
    Society of Fellows, Harvard University, Cambridge, Massachusetts, United States of America Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, United States of America
    PLoS ONE 9:e95194. 2014
    ..Our phosphoproteomic analysis indicated that two kinases, BRSK1 and CAMKK2, exhibit decreased phosphorylation in beta cells compared to alpha cells, and in compound-treated alpha ..
  10. ncbi 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK
    Abdallah K Al-Hakim
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 118:5661-73. 2005
    ..To our knowledge, this study provides the first example of 14-3-3 binding directly to the T-loop of a protein kinase and influencing its catalytic activity and cellular localization...
  11. doi Decreased expression and prognostic role of cytoplasmic BRSK1 in human breast carcinoma: correlation with Jab1 stability and PI3K/Akt pathway
    Hua Wang
    Department of General Surgery, The Affiliated Hospital of Nantong University, Medical College of Nantong University, Nantong 226001, Jiangsu, PR China
    Exp Mol Pathol 97:191-201. 2014
    ..The objective of this study was to examine the effect of brain specific kinase 1 (BRSK1) expression on Jab1 over-expression and related signaling pathway in breast cancer.
  12. pmc Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin
    Martin Voss
    Medical Research Council Protein Phosphorylation and Ubiquitylation Unit College of Life Sciences University of Dundee Dundee, Scotland, UK
    Cell Cycle 12:2876-87. 2013
    ..Recombinant γ-tubulin can be phosphorylated by Cdk1-cyclin B or Brsk1 and dephosphorylated by Ppp4c-R2-R3A in vitro...
  13. doi The regulation and function of the NUAK family
    XiangLan Sun
    Department of Endocrinology Central Laboratory, Provincial Hospital affiliated to Shandong University, Jinan, China Department of Endocrinology and Metabolism, Taipei City Hospital, Ren Ai Branch, Taipei, Taiwan Department of Dentistry, School of Dentistry, Institute of Oral Biology, National Yang Ming University, Taipei, Taiwan Department of Education and Research, Taipei City Hospital, Taipei, Taiwan
    J Mol Endocrinol 51:R15-22. 2013
    ..Twelve AMPK-related kinases (ARKs; BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK) have been identified recently...
  14. pmc Evaluating GWAS-identified SNPs for age at natural menopause among chinese women
    Chong Shen
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 8:e58766. 2013
    ..No study has been conducted to evaluate whether these findings can be generalized to Chinese women...
  15. pmc Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study
    C L Carty
    Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Hum Reprod 28:1695-706. 2013
    ..identified in genome-wide association studies (GWAS) of age at menarche (AM) and age at natural menopause (ANM) replicate in women of diverse race/ancestry from the Population Architecture using Genomics and Epidemiology (PAGE) Study?..
  16. pmc Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study
    Kylee L Spencer
    Department of Biology and Environmental Science, Heidelberg University, Tiffin, Ohio, United States of America
    PLoS ONE 8:e55258. 2013
    ..or generalized one previously identified variant for AM, rs1361108/CENPW, and two variants for ANM, rs897798/BRSK1 and rs769450/APOE, to our African American cohort...
  17. doi Genetic variation may modify ovarian reserve in female childhood cancer survivors
    W van Dorp
    Department of Paediatric Oncology Haematology, ErasmusMC University Medical Centre Sophia s Children s Hospital Rotterdam, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Hum Reprod 28:1069-76. 2013
    ..Are genetic polymorphisms, previously identified as being associated with age at menopause in the healthy population, associated with ovarian reserve and predicted age at menopause in adult long-term survivors of childhood cancer?..
  18. pmc Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study
    Christina T L Chen
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 21:1419-32. 2012
    ..LRP18, LIN28B, CENPW, INHBA, TMEM38B, ZNF483, NFAT5 and OLFM2) with age at menarche, and of two loci (MCM8 and BRSK1/TMEM150B) with age at menopause. The MCM8 locus was also associated with early menopause risk...
  19. pmc ESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure
    Yingying Qin
    Center for Reproductive Medicine, Provincial Hospital affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China
    Orphanet J Rare Dis 7:5. 2012
    ..We sought to determine if sequence variants previously associated with age at natural menopause (AANM) or early menopause (EM) contribute as well to genetic susceptibility to POF...
  20. pmc Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation
    Nicola J Bright
    Medical Research Council Cellular Stress Group, MRC Clinical Sciences Centre, Du Cane Road, London, United Kingdom
    J Biol Chem 283:14946-54. 2008
    Brain-specific kinases 1 and 2 (BRSK1/2) are AMP-activated protein kinase (AMPK)-related kinases that are highly expressed in mammalian forebrain...
  21. doi Brain specific kinase-1 BRSK1/SAD-B associates with lipid rafts: modulation of kinase activity by lipid environment
    Arantza Rodríguez-Asiain
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Barcelona, Spain
    Biochim Biophys Acta 1811:1124-35. 2011
    Brain specific kinases 1 and 2 (BRSK1/2, also named SAD kinases) are serine-threonine kinases specifically expressed in the brain, and activated by LKB1-mediated phosphorylation of a threonine residue at their T-loop (Thr189/174 in human ..
  22. pmc Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP
    Sarah Fogarty
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, U K
    Biochem J 426:109-18. 2010
    ..in intact cells or cell-free assays by CaMKKbeta, although we did observe a slow phosphorylation and activation of BRSK1 (brain-specific kinase 1) by CaMKKalpha...
  23. doi SADB phosphorylation of gamma-tubulin regulates centrosome duplication
    Maria Alvarado-Kristensson
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Madrid, Spain
    Nat Cell Biol 11:1081-92. 2009
    ..We propose that SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin...
  24. pmc Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
    Chunyan He
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Genet 41:724-8. 2009
    ..3 (in the gene MCM8), 19q13.42 (in or near the gene BRSK1), 5q35.2 (in or near genes UIMC1 and HK3) and 6p24.2 (in the gene SYCP2L)...
  25. pmc Loci at chromosomes 13, 19 and 20 influence age at natural menopause
    Lisette Stolk
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Nat Genet 41:645-7. 2009
    ..5 year per A allele (12%); P = 2.5 × 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease...
  26. doi The regulation and function of mammalian AMPK-related kinases
    N J Bright
    Cellular Stress Group, MRC Clinical Sciences Centre, London, UK
    Acta Physiol (Oxf) 196:15-26. 2009
    ..Recently, 12 AMPK-related kinases (BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) were identified that are closely related ..
  27. pmc C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest
    Sarah Fogarty
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 284:77-84. 2009
    ..protein kinase (AMPK) and members of the AMPK-related kinase family, such as the brain-specific kinases BRSK1/BRSK2 (SAD-B/SAD-A)...
  28. doi Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains
    Abdallah K Al-Hakim
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 411:249-60. 2008
    ..The results of the present study demonstrate that NUAK1 and MARK4 are substrates of USP9X and provide the first evidence that AMPK family kinases are regulated by unusual Lys(29)/Lys(33)-linked polyubiquitin chains...
  29. ncbi Mapping of a translocation breakpoint in a Peutz-Jeghers hamartoma to the putative PJS locus at 19q13.4 and mutation analysis of candidate genes in polyp and STK11-negative PJS cases
    Nicholas Hearle
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom
    Genes Chromosomes Cancer 41:163-9. 2004
    ..No pathogenic mutations in the candidate genes were identified. This report provides further evidence of the existence of a second PJS disease locus at 19q13.4 and excludes involvement of eight candidate genes...
  30. ncbi Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function
    Rui Lu
    Department of Biochemistry and Cell Biology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Biol Chem 279:31164-70. 2004
    ..The identification of this new kinase suggests the existence of an alternative checkpoint pathway other than those of ATR-Chk1 and p38MAPK...

Research Grants1

  1. Laurie J Goodyear; Fiscal Year: 2016
    ..proteins involved in exercise-stimulated glucose transport including the AMPK-related kinases SNARK, QSK, and BRSK1, the actin motor protein Myo-1c, and the calcium mediated protein CaMKII...