brain derived neurotrophic factor

Summary

Gene Symbol: brain derived neurotrophic factor
Description: brain derived neurotrophic factor
Alias: ANON2, BULN2, brain-derived neurotrophic factor, abrineurin, neurotrophin
Species: human

Top Publications

  1. pmc Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment
    M L Molendijk
    Department of Clinical Health and Neuropsychology, Leiden University, Leiden, The Netherlands
    Mol Psychiatry 16:1088-95. 2011
  2. doi Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    Gudmar Thorleifsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:18-24. 2009
  3. ncbi BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects
    Joshua A Bueller
    Mental Health Research Institute, The University of Michigan, Ann Arbor, Michigan, USA
    Biol Psychiatry 59:812-5. 2006
  4. ncbi Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Arch Gen Psychiatry 60:804-15. 2003
  5. ncbi Brain-derived neurotrophic factor (BDNF) and type 2 diabetes
    K S Krabbe
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 50:431-8. 2007
  6. ncbi Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression
    Thomas Frodl
    Department of Psychiatry and Psychotherapy and Radiology, Ludwig Maximilians University, Munich, Germany
    Arch Gen Psychiatry 64:410-6. 2007
  7. ncbi BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Neuropsychopharmacology 33:2200-5. 2008
  8. ncbi BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex
    Jeffrey A Kleim
    Brain Research Rehabilitation Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA
    Nat Neurosci 9:735-7. 2006
  9. ncbi Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia
    Monica Gratacos
    Genes and Disease Program, Center for Genomic Regulation CRG, Psychiatry Department, Hospital Universitari de Bellvitge, Barcelona, Spain
    Biol Psychiatry 61:911-22. 2007
  10. pmc The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study
    Maria Neves-Pereira
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, M5T 1R8, Canada
    Am J Hum Genet 71:651-5. 2002

Research Grants

  1. Mechanism of Neurotrophin Latency Response in a HSV1 Vestibular Neuritis Model
    PAMELA CAROL ROEHM; Fiscal Year: 2013
  2. Regulation of neurotrophin expression in the periphery
    LORI ISAACSON; Fiscal Year: 2009
  3. MECHANISMS OF ESTROGEN ACTION IN THE DEVELOPING CNS
    Dominique Toran Allerand; Fiscal Year: 2000
  4. Lisa M Monteggia; Fiscal Year: 2016
  5. Regulation of neurotransmitter properties by target-derived neurotrophic factors
    Susan J Birren; Fiscal Year: 2010
  6. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2011
  7. Neurotrophic Mechanisms in Retinal Ganglion Cell Maturation
    Xiaorong Liu; Fiscal Year: 2011
  8. Baoji Xu; Fiscal Year: 2014
  9. Roles of BDNF in Striatal Neurons and Relevance to Huntington's Disease
    Baoji Xu; Fiscal Year: 2010
  10. ANTHONY JOHN KANAI; Fiscal Year: 2016

Detail Information

Publications452 found, 100 shown here

  1. pmc Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment
    M L Molendijk
    Department of Clinical Health and Neuropsychology, Leiden University, Leiden, The Netherlands
    Mol Psychiatry 16:1088-95. 2011
    Recent evidence supports 'the neurotrophin hypothesis of depression' in its prediction that brain-derived neurotrophic factor (BDNF) is involved in depression...
  2. doi Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    Gudmar Thorleifsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:18-24. 2009
    ..6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity...
  3. ncbi BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects
    Joshua A Bueller
    Mental Health Research Institute, The University of Michigan, Ann Arbor, Michigan, USA
    Biol Psychiatry 59:812-5. 2006
    ....
  4. ncbi Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Arch Gen Psychiatry 60:804-15. 2003
    ....
  5. ncbi Brain-derived neurotrophic factor (BDNF) and type 2 diabetes
    K S Krabbe
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 50:431-8. 2007
    ..These disorders are associated with type 2 diabetes, and animal models suggest that BDNF plays a role in insulin resistance. We therefore explored whether BDNF plays a role in human glucose metabolism...
  6. ncbi Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression
    Thomas Frodl
    Department of Psychiatry and Psychotherapy and Radiology, Ludwig Maximilians University, Munich, Germany
    Arch Gen Psychiatry 64:410-6. 2007
    ..Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity, which is believed to be altered in patients with major depression...
  7. ncbi BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Neuropsychopharmacology 33:2200-5. 2008
    ..Our results suggest that variation in the BDNF gene may be a risk factor for weight gain in male patients with schizophrenia on long-term antipsychotic treatment, and decreased BDNF levels may be associated with weight gain in females...
  8. ncbi BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex
    Jeffrey A Kleim
    Brain Research Rehabilitation Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA
    Nat Neurosci 9:735-7. 2006
    ..The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex...
  9. ncbi Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia
    Monica Gratacos
    Genes and Disease Program, Center for Genomic Regulation CRG, Psychiatry Department, Hospital Universitari de Bellvitge, Barcelona, Spain
    Biol Psychiatry 61:911-22. 2007
    ..The valine (Val)66-to-methionine (Met) variant, located in the pro brain-derived neurotrophic factor (BDNF) sequence, has been extensively studied through linkage and association approaches in several psychiatric disorders...
  10. pmc The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study
    Maria Neves-Pereira
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, M5T 1R8, Canada
    Am J Hum Genet 71:651-5. 2002
    ..Rather, the causative site is likely nearby and in linkage disequilibrium with the 3-G haplotype that we have identified...
  11. pmc The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF Val66Met
    Bernet M Elzinga
    Department of Clinical Health and Neuropsychology, Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands
    Psychopharmacology (Berl) 214:319-28. 2011
    ....
  12. doi Interaction of BDNF and COMT polymorphisms on paired-associative stimulation-induced cortical plasticity
    A Veronica Witte
    Department of Neurology, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    J Neurosci 32:4553-61. 2012
    ..Moreover, they show that genotype-related differences in neurophysiology translate into behavioral differences. These findings might contribute to a better understanding of the mechanisms of interindividual differences in cognition...
  13. ncbi Association study of a brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and personality trait and intelligence in healthy young females
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neuropsychobiology 49:13-6. 2004
    ..In contrast to a recent report, however, this polymorphism does not appear to be associated with the neuroticism-related personality trait...
  14. ncbi The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression
    Qiang Chang
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Neuron 49:341-8. 2006
    ..Our results provide in vivo evidence for a functional interaction between Mecp2 and Bdnf and demonstrate the physiological significance of altered BDNF expression/signaling in RTT disease progression...
  15. doi Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity
    M Verhagen
    Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mol Psychiatry 15:260-71. 2010
    ..Our results suggest that the BDNF Val66Met polymorphism is of greater importance in the development of MDD in men than in women. Future research into gender issues will be of interest...
  16. ncbi A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival
    Roger N Pearse
    Division of Hematology, Cornell University Medical College, Rm C 606, 1300 York Ave, New York, NY 10021, USA
    Blood 105:4429-36. 2005
    ..We present evidence that brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family of growth factors, and its high-affinity receptor, tropomyosin receptor kinase B (TrkB), contribute to ..
  17. doi A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression
    Andre Russowsky Brunoni
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Int J Neuropsychopharmacol 11:1169-80. 2008
    ..34, 95% CI 0.02-0.66). Our results show that BDNF levels are associated with clinical changes in depression; supporting the notion that depression improvement is associated with neuroplastic changes...
  18. pmc Plasma BDNF is associated with age-related white matter atrophy but not with cognitive function in older, non-demented adults
    Ira Driscoll
    Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland, United States of America
    PLoS ONE 7:e35217. 2012
    b>Brain derived neurotrophic factor (BDNF) seems to be involved in regulation of synaptic plasticity and neurogenesis...
  19. ncbi Brain-derived neurotrophic factor/TrkB signaling in memory processes
    Kiyofumi Yamada
    Laboratory of Experimental Therapeutics, Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa 920 0934, Japan
    J Pharmacol Sci 91:267-70. 2003
    ..A Src-family tyrosine kinase, Fyn plays a role in this interaction by linking TrkB with NR2B. These findings suggest that BDNF/TrkB signaling in the hippocampus plays a crucial role in learning and memory...
  20. doi Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene
    Priit Pruunsild
    Institute of Gene Technology, Tallinn University of Technology, 12618 Tallinn, Estonia
    J Neurosci 31:3295-308. 2011
    ..Together, the results of this study have identified the cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene...
  21. pmc DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression
    Manabu Fuchikami
    Division of Frontier Medicine, Department of Psychiatry and Neurosciences, Graduate School of Medical Sciences, Hiroshima University, Hiroshima, Japan
    PLoS ONE 6:e23881. 2011
    ..Despite the small number of subjects, our results indicate that classification based on the DNA methylation profiles of CpG I of the BDNF gene may be a valuable diagnostic biomarker for major depression...
  22. pmc Interaction between the BDNF gene Val/66/Met polymorphism and morning cortisol levels as a predictor of depression in adult women
    J Herbert
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0SP, UK
    Br J Psychiatry 201:313-9. 2012
    ..Much less is known about how they interact with individual differences in cortisol, although these also represent a risk for major depression...
  23. doi DNA methylation and expression profiles of the brain-derived neurotrophic factor (BDNF) and dopamine transporter (DAT1) genes in patients with schizophrenia
    Dor Mohammad Kordi-Tamandani
    Department of Biology, University of Sistan and Baluchestan, P O Box 98155 987, Zahedan, Iran
    Mol Biol Rep 39:10889-93. 2012
    ..However, further populations with large sample sizes need to be studied to verify the exact role of BDNF in mental disorders such as schizophrenia...
  24. ncbi BDNF A196G and C270T gene polymorphisms and susceptibility to multiple sclerosis in the Polish population. Gender differences
    Dagmara Mirowska-Guzel
    2nd Department of Neurology, Institute of Psychiatry and Neurology, Sobieskiego 9, 02 957 Warsaw, Poland
    J Neuroimmunol 193:170-2. 2008
    ..01), but it was limited to males. Our results show that C270T and G196A BDNF polymorphisms may affect susceptibility to and onset of MS, but further verification is needed, with special attention to gender differences...
  25. pmc Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks
    Nancy A Dennis
    Department of Psychology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Hippocampus 21:980-9. 2011
    Brain-derived neurotrophic factor (BDNF) is a neurotrophin which has been shown to regulate cell survival and proliferation, as well as synaptic growth and hippocampal long-term potentiation...
  26. doi Hippocampal volume and the brain-derived neurotrophic factor Val66Met polymorphism in first episode psychosis
    Geoffrey N Smith
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Schizophr Res 134:253-9. 2012
    ..Secondary analyses explored age-related associations and the relationship between Val66Met and memory...
  27. ncbi Purification and identification of brain-derived neurotrophic factor from human serum
    R D Rosenfeld
    Amgen Center, Thousand Oaks, California 91320, USA
    Protein Expr Purif 6:465-71. 1995
    ..The presence of high levels of BDNF in serum suggests a role for this neurotrophin either in nerve repair at sites of injured tissue or in nonneuronal functions.
  28. ncbi Variant BDNF (Val66Met) impact on brain structure and function
    Kevin G Bath
    Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, Box 244, New York, NY 10021, USA
    Cogn Affect Behav Neurosci 6:79-85. 2006
    ..behavior, anatomy, and cognition in adults is an important first step in linking genetic alterations in the neurotrophin system to definable biological outcomes in humans...
  29. doi Cardio-respiratory fitness, habitual physical activity and serum brain derived neurotrophic factor (BDNF) in men and women
    James Currie
    School of Life Sciences, Oxford Brookes University, United Kingdom
    Neurosci Lett 451:152-5. 2009
    ..This is the first study to demonstrate an inverse relationship between a physiological estimate of cardio-respiratory fitness and serum BDNF...
  30. pmc Increased serum levels of brain-derived neurotropic factor during migraine attacks: a pilot study
    Marco Túlio A Tanure
    School of Health Sciences of Santa Casa de Misericórdia de Vitória, Vitoria, Brazil
    J Headache Pain 11:427-30. 2010
    ..This is the first report showing that BDNF serum levels increase during migraine attack. This reinforces the view that BDNF may be implicated in the physiopathology of migraine...
  31. doi Association study between BDNF C-281A polymorphism and paranoid schizophrenia in Polish population
    Renata Suchanek
    Department of Medical Genetics, Medical University of Silesia, Ostrogorska 30 Street, 41 200, Sosnowiec, Poland
    J Mol Neurosci 46:217-22. 2012
    ..9875; p < 0.05). The haplotype analysis has shown a tendency to a significantly lower frequency of the Met-C haplotype in the schizophrenia group compared to the controls...
  32. ncbi Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
    C Zuccato
    Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Science 293:493-8. 2001
    ..This leads to insufficient neurotrophic support for striatal neurons, which then die. Restoring wild-type huntingtin activity and increasing BDNF production may be therapeutic approaches for treating HD...
  33. ncbi Altered brain-derived neurotrophic factor blood levels and gene variability are associated with anorexia and bulimia
    J M Mercader
    Genes and Disease Program, Center for Genomic Regulation, Barcelona Biomedical Research Park, Barcelona, Catalonia, Spain
    Genes Brain Behav 6:706-16. 2007
    ..To further test the role of this neurotrophin in humans, we screened 36 SNPs in the BDNF gene and tested for their association with ED and plasma BDNF levels ..
  34. ncbi Overexpression of BDNF and TrkB in human bladder cancer specimens
    Pei Chun Lai
    Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien 970, Taiwan, ROC
    Oncol Rep 24:1265-70. 2010
    ..In conclusion, the existence of overexpressed BDNF and TrkB in human TCC has been demonstrated in our study. A strategy involving BDNF/TrkB blockade may be a new hope for TCC target therapy...
  35. doi Early adversity and 5-HTT/BDNF genes: new evidence of gene-environment interactions on depressive symptoms in a general population
    M Aguilera
    Unitat d Antropologia, Departament Biologia Animal, Facultat de Biologia, Universitat de Barcelona and CIBER de Salud Mental, Instituto de Salud Carlos III, Spain
    Psychol Med 39:1425-32. 2009
    ..The aim of this study was to analyse the putative interaction between the 5-HTT gene (5-HTTLPR polymorphism), the BDNF gene (Val66Met polymorphism) and childhood adversity in accounting for adult depressive symptoms...
  36. doi The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease
    Aristotle N Voineskos
    Department of Psychiatry, Geriatric Mental Health Program, Centre for Addiction and Mental Health, 250 College St, Toronto, Ontario, Canada M5T 1R8
    Arch Gen Psychiatry 68:198-206. 2011
    ..Imaging-genetics strategies may clarify the manner in which BDNF gene variation predicts the risk of AD via characterization of its effects on at-risk structures or neural networks susceptible in this disorder...
  37. doi Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome
    Christy W H Au
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Cancer Lett 281:151-61. 2009
    ..Our findings suggest that BDNF/TrkB pathway is important in ovarian carcinogenesis and TrkB may be a potential therapeutic target for ovarian cancer...
  38. doi Expression of hippocampal brain-derived neurotrophic factor and its receptors in Stanley consortium brains
    J S Dunham
    Stanley Brain Research Laboratory, Neuroscience and Psychiatry Unit, G700, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    J Psychiatr Res 43:1175-84. 2009
    ..Hippocampal (pro)BDNF and receptor levels were also affected by genotype, suggesting that allelic variations are important in the hippocampal abnormalities seen in these psychiatric disorders...
  39. doi BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA Study
    Pirjo Komulainen
    Kuopio Research Institute of Exercise Medicine, Finland
    Neurobiol Learn Mem 90:596-603. 2008
    ..BDNF was not associated with cognition in men. Present data suggest that plasma BDNF is a biomarker of impaired memory and general cognitive function in ageing women...
  40. ncbi Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay
    S F Radka
    Regeneron Pharmaceuticals, Inc, Tarrytown, NY 10591, USA
    Brain Res 709:122-301. 1996
    ..The presence of BDNF protein in blood and brain regions at quantities which greatly exceed those described for NGF confirm the abundant distribution of this broadly-acting neurotrophic factor...
  41. pmc Promoter specific alterations of brain-derived neurotrophic factor mRNA in schizophrenia
    J Wong
    Schizophrenia Research Institute, Sydney, Australia
    Neuroscience 169:1071-84. 2010
    ....
  42. doi Maternal smoking during pregnancy is associated with epigenetic modifications of the brain-derived neurotrophic factor-6 exon in adolescent offspring
    Maria Toledo-Rodriguez
    Brain and Body Centre, University of Nottingham, Nottingham, UK
    Am J Med Genet B Neuropsychiatr Genet 153:1350-4. 2010
    ..Such mechanisms could, in turn, lead to modifications in both development and plasticity of the brain exposed in utero to maternal cigarette smoking...
  43. doi Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance
    Aya Fujinami
    Department of Medical Biochemistry, Kobe Pharmaceutical University, 4 19 1 Motoyama kita machi, Higashinada ku, Kobe, 658 8558, Japan
    Clin Biochem 41:812-7. 2008
    ....
  44. ncbi Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type
    M Ribases
    Genes and Disease Program, Center for Genomic Regulation, Barcelona, Catalonia, Spain
    Mol Psychiatry 8:745-51. 2003
    ..These findings, together with the fact that this neurotrophin is expressed in the hypothalamus nuclei associated with weight regulation and feeding control, led us to ..
  45. ncbi Estrogen regulates the development of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus
    Derek T Solum
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci 22:2650-9. 2002
    ..These results suggest that a direct interaction may exist between ERalpha and BDNF to alter hippocampal physiology during development in the rat...
  46. pmc Interaction between 5-HTTLPR and BDNF Val66Met polymorphisms on HPA axis reactivity in preschoolers
    Lea R Dougherty
    Department of Psychology, Stony Brook University, NY, United States
    Biol Psychol 83:93-100. 2010
    ....
  47. pmc No association of genetic variants in BDNF with major depression: a meta- and gene-based analysis
    Joseph P Gyekis
    Department of Biobehavioral Health, Pennsylvania State University, State College, PA 16801, USA
    Am J Med Genet B Neuropsychiatr Genet 162:61-70. 2013
    ..The association of MDD with genetic polymorphisms, such as Val66Met (rs6265), in the brain derived neurotrophic factor (BDNF), have been reported in many studies and the results were conflicting...
  48. doi DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients
    Tempei Ikegame
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Res 77:208-14. 2013
    ..Epigenetic alteration of BDNF in the PBC might reflect the pathophysiology of schizophrenia, and could be a potential biomarker. ..
  49. doi BDNF promoter methylation and suicidal behavior in depressive patients
    Hee Ju Kang
    Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea
    J Affect Disord 151:679-85. 2013
    ..This study investigated whether epigenetic changes are associated with suicidal behavior and evaluated the treatment outcome of suicidal ideation in depressive patients...
  50. ncbi Plasma brain derived neurotrophic factor levels and neuropsychological aspects of depressed patients treated with paroxetine
    D Munno
    Unit of Clinical Psychology Department of Neuroscience University of Turin, Turin, Italy
    Panminerva Med 55:377-84. 2013
    ..Hippocampus is linked to memory and learning and BDNF is abundant in this area. For this reason we investigated the presence of any association between paroxetine treatment, BDNF levels and cognitive performances in depressed patients...
  51. ncbi Age-related changes in BDNF protein levels in human serum: differences between autism cases and normal controls
    Ritsuko Katoh-Semba
    Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan
    Int J Dev Neurosci 25:367-72. 2007
    ..In a separate study of adult rats, a circadian change in serum BDNF was found to be similar to that in the cortex, indicating a possible association with cortical functions...
  52. ncbi A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the Apolipoprotein E epsilon4 allele
    M Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Mol Psychiatry 7:782-5. 2002
    ..The results suggest that the BDNF C-270T polymorphism is a relevant risk factor for AD particularly in patients lacking the ApoE epsilon4 allele in this German sample...
  53. ncbi Increased brain-derived neurotrophic factor expression in white blood cells of relapsing-remitting multiple sclerosis patients
    A Gielen
    Department of Medicine, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden
    Scand J Immunol 57:493-7. 2003
    ..Herein, we analysed neurotrophin and cytokine mRNA levels using TaqMan polymerase chain reaction in unstimulated peripheral blood mononuclear ..
  54. ncbi Interaction between BDNF Val66Met and childhood trauma on adult's violent suicide attempt
    N Perroud
    Department of Psychiatry, University Hospital of Geneva, Switzerland
    Genes Brain Behav 7:314-22. 2008
    ..It is proposed that childhood sexual abuse elicits brain structural modifications through BDNF dysfunction and enhances the risk of violent SB in adulthood...
  55. doi BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia
    Janusz K Rybakowski
    Department of Adult Psychiatry, Poznan University of Medical Science, Szpitalna 27 33, 60 572 Poznan, Poland
    Pharmacogenomics 9:1589-93. 2008
    ..It has been demonstrated that the functional Val66Met polymorphism of the gene can be associated with a number of clinical and pharmacological phenomena in these illnesses...
  56. pmc Epigenetic regulation of BDNF expression via the scaffolding protein RACK1
    Dao Yao He
    Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Biol Chem 285:19043-50. 2010
    ..Furthermore, this novel mechanism for the regulation of exon-specific expression of the BDNF gene by RACK1 could have implications on the neuronal functions of the growth factor including synaptic plasticity, learning, and memory...
  57. doi Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis
    Charles S Carver
    Department of Psychology, University of Miami, Coral Gables FL 33124, United States
    J Affect Disord 132:89-93. 2011
    ..BDNF interacted with Risk such that Risk predicted greater likelihood of MDD among met carriers and did not influence val/val carriers. These two interactions were additive: both were significant in a combined model...
  58. pmc Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
    Oliver Gruber
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:23-31. 2012
    ..BDNF genotype had a numerical, but nonsignificant effect on verbal memory performance. These findings provide first in vivo evidence for an effect of the functional BDNF val66met polymorphism on the glutamate system in human hippocampus...
  59. pmc Polymorphisms in the brain-derived neurotrophic factor gene influence memory and processing speed one month after brain injury
    Thomas W McAllister
    Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire 05756, USA
    J Neurotrauma 29:1111-8. 2012
    ..Polymorphisms in BDNF influence cognitive performance shortly after mTBI. The results raise the possibility that a functional polymorphism other than rs6265 may contribute to memory function after mTBI...
  60. doi Expression of TrkB and BDNF is associated with poor prognosis in non-small cell lung cancer
    Kyoko Okamura
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Japan
    Lung Cancer 78:100-6. 2012
    ..Our results indicate that expression of TrkB and BDNF is associated with poor prognosis in NSCLC patients...
  61. pmc Brain-derived neurotrophic factor val66met genotype and early life stress effects upon bipolar course
    Shefali Miller
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, USA
    J Psychiatr Res 47:252-8. 2013
    ..We examined effects of brain-derived neurotrophic factor (BDNF) val66met genotype and early life stress (ELS) upon illness severity and chronicity in adult BD patients...
  62. pmc Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene
    N Perroud
    Department of Psychiatry, University of Geneva, Chene Bourg, Switzerland
    Transl Psychiatry 3:e207. 2013
    ..These results moreover support the idea that these epigenetic marks may be changed through psychotherapeutic approaches and that these changes underline changes in cognitive functions...
  63. doi BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria, Australia
    Neurobiol Aging 34:2457-64. 2013
    ..High Aβ levels coupled with Met carriage may be useful prognostic markers of accelerated cognitive decline and hippocampal degeneration in individuals in the preclinical stage of AD. ..
  64. ncbi No association of the brain-derived neurotrophic factor (BDNF) gene C-270T polymorphism with schizophrenia
    Aleksandra Szczepankiewicz
    Laboratory of Psychiatric Genetics, University of Medical Sciences, ul Szpitalna 27 33, 60 572 Poznan, Poland
    Schizophr Res 76:187-93. 2005
    ..078 and p=0.162 respectively and for females: p=0.441 and p=0.315. Thus, our data indicate that variations in the BDNF gene are unlikely to be an important factor in susceptibility to schizophrenia...
  65. doi A longitudinal observation of brain-derived neurotrophic factor mRNA levels in patients with relapsing-remitting multiple sclerosis
    Maria Liguori
    Institute of Neurological Sciences, National Research Council, Contrada Burga, Mangone, Cosenza 87050, Italy
    Brain Res 1256:123-8. 2009
    ..Although with caution due to the small sample size, it also underscores the potential role of the Val66Met polymorphism on the peripheral BDNF expression in RRMS. Functional studies are needed to better clarify this issue...
  66. pmc Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival
    Hussein Akil
    Universite de Limoges, Laboratoire EA 3842, Homéostasie Cellulaire et Pathologies, Faculte de Medecine et de Pharmacie, Limoges, France
    PLoS ONE 6:e25097. 2011
    b>Neurotrophin receptors were initially identified in neural cells...
  67. pmc Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia
    Beng Choon Ho
    Department of Psychiatry, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Am J Psychiatry 164:1890-9. 2007
    ..Factors underlying progressive brain volume changes in schizophrenia remain poorly understood. The authors investigated whether a gene polymorphism influencing neuroplasticity may contribute to longitudinal brain volume alterations...
  68. doi Brain-derived neurotrophic factor induces proliferation, migration, and VEGF secretion in human multiple myeloma cells via activation of MEK-ERK and PI3K/AKT signaling
    Chun Yan Sun
    Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Dadao, Wuhan, 430022, People s Republic of China
    Tumour Biol 31:121-8. 2010
    ..BDNF affects different cell signaling pathways mediating growth, migration, and VEGF secretion in MM cells. Our observations provided the framework for novel therapeutic strategies targeting BDNF signaling cascades in MM...
  69. pmc BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects
    Meghana S Karnik
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Psychiatry Res 178:425-9. 2010
    ..We concluded that in a large cohort of healthy human subjects, the Met allele of rs6265 is not associated with hippocampal structure or memory performance...
  70. doi Quadri-pulse stimulation (QPS) induced LTP/LTD was not affected by Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene
    Koichiro Nakamura
    Department of Neurology, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960 1295, Japan
    Neurosci Lett 487:264-7. 2011
    It has been reported that the brain derived neurotrophic factor (BDNF) has some functional roles in inducing plasticity in the adult human brain and the Val66Met BDNF polymorphism affects the plasticity induction...
  71. pmc Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing
    Miao Yang
    Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia
    J Biol Chem 286:16272-84. 2011
    ..Furthermore, the complex facilitates furin cleavage to release mature BDNF...
  72. doi Brain-derived neurotrophic factor is a potential osteoclast stimulating factor in multiple myeloma
    Chun Yan Sun
    Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Dadao, Wuhan 430022, People s Republic of China
    Int J Cancer 130:827-36. 2012
    ..These results support an important role for BDNF in the development of myeloma bone disease...
  73. doi Decreased serum brain-derived neurotrophic factor concentration in young nonobese subjects with low insulin sensitivity
    Monika Karczewska-Kupczewska
    Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Poland
    Clin Biochem 44:817-20. 2011
    ..The aim of our study was to estimate serum BDNF concentration in nonobese women divided into subgroups according to their insulin sensitivity...
  74. doi The association of the alpha-5 subunit of the nicotinic acetylcholine receptor gene and the brain-derived neurotrophic factor gene with different aspects of smoking behavior
    Elemi J Breetvelt
    Departments of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Psychiatr Genet 22:96-8. 2012
    ..Overall, the results confirm the involvement of the CHRNA5 gene in the amount of nicotine use and further suggest involvement of the BDNF gene in smoking behavior...
  75. doi Val66Met in brain-derived neurotrophic factor affects stimulus-induced plasticity in the human pharyngeal motor cortex
    Vanoo Jayasekeran
    Inflammation Sciences Research Group, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK
    Gastroenterology 141:827-836.e1-3. 2011
    ..We examined whether this SNP influenced outcomes of different forms of neurostimulation applied to the pharyngeal motor cortex...
  76. doi Diurnal variation of plasma brain-derived neurotrophic factor (BDNF) in humans: an analysis of sex differences
    Armando Piccinni
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
    Chronobiol Int 25:819-26. 2008
    ..These findings support the concept of rhythmic variation in plasma BDNF regulation that seems to be sex-related...
  77. ncbi The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with risk for psychosis: evidence from a family-based association study
    Araceli Rosa
    Unitat d Antropologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Am J Med Genet B Neuropsychiatr Genet 141:135-8. 2006
    ..Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin growth factor family, promotes the development, regeneration, and survival of neurons and has been linked to ..
  78. ncbi Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor
    P Sklar
    Department of Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Mol Psychiatry 7:579-93. 2002
    ..5 kb 3'. Therefore, this study of 76 candidate genes has identified BDNF as a potential risk allele that will require additional study to confirm...
  79. ncbi An association study of a brain-derived neurotrophic factor Val66Met polymorphism and clozapine response of schizophrenic patients
    Chen Jee Hong
    Department of Psychiatry, Taipei Veterans General Hospital, No 201 Shih Pai Road, Sec 2, 11217 Taipei, Taiwan, ROC
    Neurosci Lett 349:206-8. 2003
    ..Our finding suggests that this BDNF-gene Val66Met polymorphism may be related to schizophrenia pathogenesis in patients responsive to clozapine treatment...
  80. doi Dose-dependent effect of the Val66Met polymorphism of the brain-derived neurotrophic factor gene on memory-related hippocampal activity
    Ryota Hashimoto
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Neurosci Res 61:360-7. 2008
    ..There was no genotype effect on retrieval related brain activity. These data indicated a genetic mechanism for normal variation in human memory and suggest effects of BDNF signaling on hippocampal function in humans...
  81. doi Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families
    Aleksandra Szczepankiewicz
    Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Third Department of Pediatrics, Poznan University of Medical Sciences, PL 60 572 Poznan, Poland
    Int Arch Allergy Immunol 149:343-9. 2009
    ..Brain-derived neurotrophic factor (BDNF) is an important mediator in this interaction. The aim of this study was to analyze the possible relationship between polymorphisms of the gene encoding BDNF and susceptibility to asthma...
  82. pmc Plasma BDNF concentration, Val66Met genetic variant and depression-related personality traits
    A Terracciano
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
    Genes Brain Behav 9:512-8. 2010
    ..These findings challenge the prevailing hypothesis that lower peripheral levels of BDNF are a marker of depression...
  83. doi Inhibition of brain-derived neurotrophic factor/tyrosine kinase B signaling suppresses choriocarcinoma cell growth
    Nanami Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Endocrinology 151:3006-14. 2010
    ..Thus, autocrine signaling of the BDNF/TrkB system is important for human choriocarcinoma cell growth, and inhibition of BDNF/TrkB signaling in these cells could provide a novel therapy for patients with choriocarcinoma...
  84. pmc The role of the Met66 brain-derived neurotrophic factor allele in the recovery of executive functioning after combat-related traumatic brain injury
    Frank Krueger
    Department of Molecular Neuroscience, George Mason University, Fairfax, Virginia 22030, USA
    J Neurosci 31:598-606. 2011
    Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, promotes survival and synaptic plasticity in the human brain...
  85. doi Brain-derived neurotrophic factor promotes tumorigenesis via induction of neovascularization: implication in hepatocellular carcinoma
    Chi Tat Lam
    Department of Surgery and State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Cancer Res 17:3123-33. 2011
    ..Brain-derived neurotrophic factor (BDNF) has emerged as a novel angiogenic factor, and yet its impact on tumorigenesis is unclear. This study aimed at investigating the roles of BDNF in angiogenesis and tumor development...
  86. ncbi Whole blood BDNF levels in healthy twins discordant for affective disorder: association to life events and neuroticism
    Viktorija Trajkovska
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Section 9201, Blegdamsvej 9, 2100 Copenhagen, Denmark
    J Affect Disord 108:165-9. 2008
    ..Depression has been associated with decreased blood BDNF concentrations; but it is unclear if low blood BDNF levels are a state or a trait marker of depression...
  87. doi Plasma brain-derived neurotrophic factor daily variations in men: correlation with cortisol circadian rhythm
    Silvia Begliuomini
    Division of Gynecology and Obstetrics, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa 56100, Italy
    J Endocrinol 197:429-35. 2008
    ..Moreover, the correlation found out between BDNF and cortisol circadian trend allows us to speculate that these two factors may be physiologically co-regulated, in order to maintain the homeostasis of integrated cerebral activities...
  88. doi Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference
    Florianne Bauer
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands
    Am J Clin Nutr 90:951-9. 2009
    ..New genetic loci, most of which are expressed in the brain, have recently been reported to contribute to the development of obesity. The brain, especially the hypothalamus, is strongly involved in regulating weight and food intake...
  89. ncbi Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms
    Yoshio Momose
    Division of Functional Genomics, Department of Post Genomics and Diseases, Osaka University Graduate School of Medicine, Osaka, Japan
    Ann Neurol 51:133-6. 2002
    ..46) and confirmed an association with the S18Y polymorphism of the UCH-L1 gene. Our results provide genetic evidence supporting a role for BDNF in the pathogenesis of Parkinson's disease...
  90. ncbi Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men
    J A Zoladz
    Department of Physiology and Biochemistry, University School of Physical Education, Krakow, Poland
    J Physiol Pharmacol 59:119-32. 2008
    It is believed that brain derived neurotrophic factor (BDNF) plays an important role in neuronal growth, transmission, modulation and plasticity. Single bout of exercise can increase plasma BDNF concentration [BDNF](p) in humans...
  91. doi Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults
    Tanja Richter-Schmidinger
    Department of Psychiatry and Psychotherapy, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    J Neural Transm (Vienna) 118:249-57. 2011
    ..BDNF Val66Met polymorphism seems to influence working memory function and modulate the effects of ageing on working memory in healthy young adults...
  92. ncbi Association between BDNF val66 met genotype and episodic memory
    Emma Dempster
    Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 134:73-5. 2005
    The val66 met polymorphism of brain derived neurotrophic factor (BDNF) has been associated with variability in episodic memory [Egan et al., 2003]...
  93. pmc Effects of the brain-derived neurotrophic growth factor val66met variation on hippocampus morphology in bipolar disorder
    Lara G Chepenik
    Deparment of Psychiatry, Yale University School of Medicine, New Haven, CT 6511, USA
    Neuropsychopharmacology 34:944-51. 2009
    ....
  94. pmc Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder
    Diana Hall
    The Rockefeller University, Human Neurogenetics Laboratory, New York, NY, 10021, USA
    Am J Hum Genet 73:370-6. 2003
    ....
  95. ncbi Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations
    P C Maisonpierre
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591
    Genomics 10:558-68. 1991
    ..Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are two recently cloned neurotrophic factors that are homologous to NGF...
  96. pmc Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters
    Priit Pruunsild
    Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, Tallinn 19086, Estonia
    Genomics 90:397-406. 2007
    ..We show that BDNF and antiBDNF transcripts form dsRNA duplexes in the brain in vivo, suggesting an important role for antiBDNF in regulating BDNF expression in human...
  97. doi Effect of brain-derived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment
    Orestes Vicente Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, SP, Brazil
    World J Biol Psychiatry 11:774-80. 2010
    ..We also address the impact of these variables on the progression of cognitive deficits within the MCI-AD continuum...
  98. doi Correlation between cortical plasticity, motor learning and BDNF genotype in healthy subjects
    P Li Voti
    Department of Neurology and Psychiatry, Sapienza, University of Rome, Viale dell Universita 30, 00185, Rome, Italy
    Exp Brain Res 212:91-9. 2011
    ..Individual success in behavioural learning is unlikely to be closely related to any single measure of synaptic plasticity...
  99. doi Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse
    Hans Jörgen Grabe
    Department of Psychiatry and Psychotherapy, University of Greifswald, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 36:264-70. 2012
    ..We tested the hypothesis of a three-way interaction with respect to depressive symptoms...
  100. doi Intense exercise increases circulating endocannabinoid and BDNF levels in humans--possible implications for reward and depression
    E Heyman
    Univ Lille Nord de France, EA4488 Activité physique, Muscle, santé, F 59000 Lille, France
    Psychoneuroendocrinology 37:844-51. 2012
    ....
  101. doi Influence of BDNF variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Neuropsychobiology 65:1-11. 2012
    ....

Research Grants96

  1. Mechanism of Neurotrophin Latency Response in a HSV1 Vestibular Neuritis Model
    PAMELA CAROL ROEHM; Fiscal Year: 2013
    ..we hypothesize that withdrawal of other neurotrophins (either brain-derived neurotrophic factor (BDNF) or neurotrophin-3 (NT3), whose Trk receptors are expressed in VGNs) leads to viral reactivation, and that these effects are ..
  2. Regulation of neurotrophin expression in the periphery
    LORI ISAACSON; Fiscal Year: 2009
    ..In addition to NGF and NT-3, both brain derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) reportedly have regulatory roles in peripheral neurons, yet a ..
  3. MECHANISMS OF ESTROGEN ACTION IN THE DEVELOPING CNS
    Dominique Toran Allerand; Fiscal Year: 2000
    ..g., nerve growth factor (NGF); brain derived neurotrophic factor (BDNF); neurotrophin-3 (NT-3)] collaborate in the differentiation and survival of CNS target neurons...
  4. Lisa M Monteggia; Fiscal Year: 2016
    ABSTRACT Brain-derived neurotrophic factor (BDNF) is the most prevalent neurotrophin in brain;via actions on its high affinity trkB receptor it enhances the survival of many types of central neurons and is implicated in several forms of ..
  5. Regulation of neurotransmitter properties by target-derived neurotrophic factors
    Susan J Birren; Fiscal Year: 2010
    ..We will investigate the neurotrophin receptors that regulate the development of cholinergic and noradrenergic synaptic transmission and examine the ..
  6. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2011
    ..NGFR binds multiple neurotrophin ligands, including nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin 3...
  7. Neurotrophic Mechanisms in Retinal Ganglion Cell Maturation
    Xiaorong Liu; Fiscal Year: 2011
    ..the investigators will focus on the roles of two neurotrophins, Brain-derived neurotrophic factor (BDNF) and Neurotrophin 3 (NT-3)...
  8. Baoji Xu; Fiscal Year: 2014
    ..We hypothesize that anterogradely transported brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) control survival and dendritic arborization of newborn MSNs...
  9. Roles of BDNF in Striatal Neurons and Relevance to Huntington's Disease
    Baoji Xu; Fiscal Year: 2010
    ..We hypothesize that brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) from nigrostriatal dopaminergic (DA) neurons support the survival of newborn MSNs within the LGE and ..
  10. ANTHONY JOHN KANAI; Fiscal Year: 2016
    ..Hypothesis: FA-NO2 are radioprotective by desensitizing TRPA1 and TRPV1 channels and BDNF-AB and NGF-AB are therapeutic by inhibiting nerve growth and sensitization in bladder and spinal cord. ..
  11. Michael K Georgieff; Fiscal Year: 2015
    ..regulation of growth factors mediating hippocampal plasticity and function in adulthood including Brain Derived Neurotrophic Factor (BDNF) and its downstream effectors...
  12. John David Sweatt; Fiscal Year: 2014
    ..The results from the proposed studies may help us to understand treatment-related pain in more detail, and may provide new molecular targets for analgesic therapy. ..
  13. NEUROCHEMICAL PHARMACOLOGY OF PHENCYCLIDINE
    Kenneth Johnson; Fiscal Year: 2009
    ..Activation and inhibition of key players in these pathways, as well as downstream activation of brain derived neurotrophic factor (BDNF) will be tested for their involvement in protecting the striatum and hippocampus from the ..
  14. Homeostatic Regulation of Presynaptic Function by Dendritic mTORC1
    FREDRICK EARL HENRY; Fiscal Year: 2013
    ....
  15. Gary B Kaplan; Fiscal Year: 2014
    ..COR is hypothesized to involve increases in brain derived neurotrophic factor (BDNF) in mesocorticolimbic dopamine neurons such as prefrontal cortex (PFC) and basolateral ..
  16. Mechanisms of BDNF and Glucocorticoid Action
    Michael J Garabedian; Fiscal Year: 2013
    ..of glucocorticoids upon neuronal circuits are also strongly influenced by neurotrophins, such as Brain Derived Neurotrophic Factor (BDNF). However, the molecular mechanism of this regulation has not been explored...
  17. Increased vulnerability of BDNF deficient mice to mild stress
    JULIE GORTON HENSLER; Fiscal Year: 2010
    ..Thus, stress-related psychiatric disorders, such as major depression, may result from a subtle atrophy or diminished function of BDNF- responsive neurons in the brain. ..
  18. Lucas D Pozzo-Miller; Fiscal Year: 2014
    ..We will test whether impaired development of hippocampal inhibitory synapses due to reduced BDNF release contributes to the excitatory/inhibitory imbalance of synaptic function implicated in cognitive impairments and autism in RTT. ..
  19. Neurotrophic Factors: Genetic Variation and Serum Levels in Brain Aging
    Sudha Seshadri; Fiscal Year: 2010
    ..to genotype a comprehensive panel of NTF and NTF receptors and measure serum levels of three NTF: brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), and vascular endothelial growth factor (VEGF) in the large, ..
  20. BDNF AND HIPPOCAMPAL HYPEREXCITABILITY
    Helen E Scharfman; Fiscal Year: 2010
    ..We also suggested that the mechanism of estrogen action was based on one of its target genes, the neurotrophin BDNF (brain-derived neurotrophic factor), which is concentrated in a major glutamatergic input to the CA3 ..
  21. Regulation of Local BDNF Synthesis in Dendrites
    Baoji Xu; Fiscal Year: 2010
    ..This research will make a significant contribution to the understanding of fragile X syndrome. ..
  22. The Role of Local BDNF Synthesis in Spine Morphogenesis
    LAUREN LYNN OREFICE; Fiscal Year: 2012
    ..abstract_text> ..
  23. Beth A Habecker; Fiscal Year: 2016
    ..Therefore, we will use genetic models to manipulate neurotrophin signaling in vivo and dissect the contributions of p75 and TrkA in post-infarct sympathetic dysregulation, ..
  24. Susan Patterson; Fiscal Year: 2016
    ..and infection interact to significantly decrease the capacity of the hippocampus to provide the brain derived neurotrophic factor (BDNF) needed for some forms of synaptic plasticity...
  25. Scott C Steffensen; Fiscal Year: 2016
    ....
  26. Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    Keqiang Ye; Fiscal Year: 2013
    ..We have recently identified a number of high-potency small mimetic molecules of brain derived neurotrophic factor. These compounds readily crossed the blood brain barrier and into the cochlea...
  27. Janet Alder; Fiscal Year: 2014
    ..Importantly, the influence of secreted neuropeptides such as VGF on neurotrophin function is not known...
  28. Small RNA regulation of BDNF expression in schizophrenia
    Schahram Akbarian; Fiscal Year: 2012
    ....
  29. Brain-derived neurotrophic factor induced weight loss: neural mechanisms
    Chuanfeng Wang; Fiscal Year: 2012
    ..Recently, several lines of evidence from our laboratory and others suggest that brain derived neurotrophic factor (BDNF) plays an important role in energy balance...
  30. Bruce K Krueger; Fiscal Year: 2016
    ..to pregnant mice during early gestation increases the expression of brain-derived neurotrophic factor (BDNF), a neurotrophin that acts as a critical modulator of neurogenesis in the fetal brain...
  31. Role of TrkB receptor and its signaling pathways in cocaine reward and addiction
    NICOLE RENEE BUZIN; Fiscal Year: 2012
    ..is further marked by drug-induced neuroadaptations that promote changes in the expression of brain derived neurotrophic factor (BDNF), neuroplasticity, and neuron morphology...
  32. Michael Chopp; Fiscal Year: 2015
    ..proteolytic cleavage of pro-neurotrophins: pro-nerve growth factor (pro-NGF) to NGF, pro-brain derived neurotrophic factor (pro-BDNF) to BDNF These hypotheses dissect the interactions of exogenous MSCs and endogenous ..
  33. Neurotrophin receptor regulation of taste development
    Liliana Minichiello; Fiscal Year: 2012
    ..buds is tightly regulated by the actions of two neurotrophins, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4)...
  34. Regulation of Sympathetic Neuron Synaptic Activity
    Susan J Birren; Fiscal Year: 2013
    ..An understanding of these mechanisms will permit new approaches for developing therapeutics for cardiac pathologies. ..
  35. Tomas R Guilarte; Fiscal Year: 2016
    ..Further, we will examine novel therapeutic manipulations that elevate BDNF release and TrKB receptor activation in order to protect against the long-term detrimental effects of Pb2+ exposure. ..
  36. Yue Feng; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Brain derived neurotrophic factor (BDNF) is a key player that governs neuronal survival, differentiation and synaptic plasticity via activation of the TrkB receptor...
  37. Prefrontal Cortex BDNF and Amygdala-Dependent Emotional LearningChallenge Area:
    Kerry J Ressler; Fiscal Year: 2010
    ..One potential molecular candidate underlying these effects may be brain derived neurotrophic factor (BDNF), a neurotrophin that is well known to be involved in neuronal plasticity and has been shown ..
  38. Masuo Ohno; Fiscal Year: 2014
    ....
  39. Neurotrophin Specificity and Function in the Taste System
    Christopher Nosrat; Fiscal Year: 2009
    ..We have shown that two members of the neurotrophin family, Brain-derived neurotrophic factor (BDNF) and Neurotrophin 3 (NT-3) play important roles in the ..
  40. THYROID HORMONE ACTION IN NEUROGENESIS
    Richard Maas; Fiscal Year: 2001
    ..Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), members of the neurotrophic factor family, may serve critical roles in this process since NT-3 and ..
  41. GROWTH FACTORS IN MAMMALIAN EYE DEVELOPMENT
    Jeffrey Bennett; Fiscal Year: 2002
    ..focused on determining the biologic function of the neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in the development and maintenance of the mammalian eye...
  42. Haifei Shi; Fiscal Year: 2015
    ..Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays essential roles in the regulation of energy balance in the CNS by promoting decreased food intake ..
  43. David P Gavin; Fiscal Year: 2016
    ..the stable downregulation of genes protective against the reinforcing effects of ethanol, such as brain derived neurotrophic factor (BDNF), may result in increased alcohol consumption...
  44. Alan Frazer; Fiscal Year: 2016
    ..Our basic research studies could have treatment implications for patients with either MDD and/or PTSD. ..
  45. John R Grider; Fiscal Year: 2016
    ..The objective of this renewal application is to characterize the role of the neurotrophin, Brain Derived Neurotrophic Factor (BDNF), in the physiology and pathophysiology of the enteric nervous system (ENS) with regard to the ..
  46. Liya Qiao; Fiscal Year: 2016
    ....
  47. Mriganka Sur; Fiscal Year: 2016
    ..Since IGF1 is FDA-approved for clinical use in children with growth failure, this study represents a valid approach for a therapeutic intervention on RTT patients. ..
  48. Epigenetic modulation of epileptogenesis.
    PEYMAN GOLSHANI; Fiscal Year: 2010
    ....
  49. DENNIS J MCGINTY; Fiscal Year: 2014
    ..By linking antidepressant treatment, sustained sleep, and adult neurogenesis, proposed work could provide a specific neurochemical rationale for development of treatment protocols which include management of sleep disorders. ..
  50. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    JOHN GRIDER; Fiscal Year: 2009
    ..The objective of this renewal application is to characterize the role of the neurotrophin, Brain Derived Neurotrophic Factor (BDNF), in the physiology and pathophysiology of the enteric nervous system (ENS) with regard to the ..
  51. Experience-Dependent Redeployment of MeCP2 Across the Mouse Genome
    Qiang Chang; Fiscal Year: 2011
    ..Furthermore, because of the considerable overlap in clinical features between RTT and autistic spectrum disorders, the lessons learned studying RTT might also benefit the general understanding of autism. ..
  52. Anuja Ghorpade; Fiscal Year: 2016
    ..In these assays, TIMP-1 had equivalent neuroprotective effects as brain derived neurotrophic factor (BDNF)...
  53. Eng H Lo; Fiscal Year: 2016
    ..g. brain derived neurotrophic factor, BDNF) that provide trophic support for neuronal health...
  54. Chun Jiang; Fiscal Year: 2015
    ....
  55. Trophic factors and regulation of hippocampal neuroplasticity in the human brain
    Maura Boldrini; Fiscal Year: 2012
    ..Immunocytochemistry for vascular endothelial growth factor (VEGF), its receptor VEGFR-2, brain derived neurotrophic factor (BDNF), its receptor TrkB will be used to identify their expression in HF cells...
  56. TrkB Agonist(s), a Potential Therapy for Autism Spectrum Disorders
    Yi Eve Sun; Fiscal Year: 2010
    ..In addition, altered regulation of brain derived neurotrophic factor (BDNF) has also been found in autistic patients. In RTT mouse models (i.e...
  57. Suzie H Pun; Fiscal Year: 2016
    ..The developed technology would have broad significance as vehicles to deliver therapeutic genes for CNS disorders. ..
  58. Regulation of BDNF Expression by Calcium-stimulated Protein Kinases
    Hongbing Wang; Fiscal Year: 2010
    ....
  59. BDNF-Estrogen Interactions with Perimenopausal Mood and Cognition
    Elizabeth M Waters; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Brain derived neurotrophic factor (BDNF) is importantly involved in anxiety, depression and cognitive function...
  60. Real-time imaging of tPA fluorescent hybrids in hippocampal neurons
    Janis E Lochner; Fiscal Year: 2011
    ..synaptic plasticity by promoting the cleavage of another secreted neuromodulatory protein, brain derived neurotrophic factor (BDNF)...
  61. Qiang Chang; Fiscal Year: 2014
    ..Furthermore, because the considerable overlap in clinical features between RTT and autistic spectrum disorders, the lessons learned studying RTT might also benefit the general understanding of autism. ..
  62. Shelley J Russek; Fiscal Year: 2016
    ..JAK)/Signal Transducer and Activator of Transcription (STAT) signaling cascade, via actions of brain derived neurotrophic factor (BDNF)...
  63. James A McRoberts; Fiscal Year: 2016
    ..Using rodent models, we will test the predictions that neuropathic and visceral pain increase NMDA-induced SP release, and decrease after selective knockdown of NMDARs in primary afferents. ..
  64. Longitudinal Imaging of Frontal Cortex Afferents in a Mouse Model of Anxiety
    LINDA E WILBRECHT; Fiscal Year: 2013
    ..b>Brain derived neurotrophic factor (BDNF) is a neurotrophic factor involved in developmental maturation of neural processes and cell ..
  65. Sunghee Cho; Fiscal Year: 2016
    ..In addition, defining a critical window for activating the CD36 pathway may lead to therapeutic strategies for promoting motor recovery in stroke patients who do not carry the SNP. ..
  66. Synaptic regulation of affective behaviors
    Ipe Ninan; Fiscal Year: 2013
    ..By undertaking this study, we expect to understand the interaction of BDNF Val66Met polymorphism and sex in the IL-mPFC and its involvement in sexual dimorphism in affective behaviors. ..
  67. Christine M Gall; Fiscal Year: 2015
    ..In all, the proposed studies are expected to test for the presence of a final, common defect in memory disorders and to thoroughly evaluate a clinically relevant strategy for normalizing synaptic plasticity and behavior. ..
  68. Karin Schon; Fiscal Year: 2015
    ..aerobic exercise, cardiovascular fitness, the functional neuroanatomy of hippocampal-dependent memory, and a neurotrophin, the Brain-Derived Neurotrophic Factor (BDNF) in humans using two memory tasks and fMRI (Specific Aim #1), 2) ..
  69. Subhash C Pandey; Fiscal Year: 2016
    ....
  70. AJAY THOMAS; Fiscal Year: 2014
    ..pathways are activated after SE that may be important contributors to epilepsy;this proposal will focus on neurotrophin signaling...
  71. Subimal Datta; Fiscal Year: 2016
    ..g., endogenous depression, schizophrenia, Alzheimer's, Huntington's, Parkinson's, and stroke), and will help us to design therapeutic interventions to eliminate these dysfunctions. ..
  72. SCOTT EDWARD KANOSKI; Fiscal Year: 2015
    ..Results will contribute to the development of pharmacological obesity treatment by informing about the neuroendocrine and intracellular/molecular systems that control food intake and food-motivated behavior. ..
  73. BDNF/TrkB Regulates Actin Signaling with LTP
    Lulu Chen; Fiscal Year: 2009
    ..The endogenous neurotrophin, brain derived neurotrophic factor (BDNF) modulates spine shape and facilitates synaptic plasticity in adult brain...
  74. ROLE OF BDNF IN THE PHOTIC CONTROL OF CIRCADIAN RHYTHMS
    David Earnest; Fiscal Year: 2003
    ..Recent findings indicate that the neurotrophin, brain- derived neurotrophic factor (BDNF0, enhances neuronal signaling in other brain regions...
  75. Estrogen Signaling and Synaptogenesis in Hippocampus: The Role of BDNF
    Joanna Spencer; Fiscal Year: 2009
    ..This proposal addresses the hypothesis that the neurotrophin, brain-derived neurotrophic factor (BDNF), mediates estradiol's actions in the hippocampus...
  76. Lei Cao; Fiscal Year: 2014
    ....
  77. Russell W Brown; Fiscal Year: 2015
    ..The critical hypothesis tested is that adult rats neonatally treated with quinpirole wil self-administer more nicotine than animals neonatally treated with saline. ..
  78. SHANNON LEIGH GOURLEY; Fiscal Year: 2014
    ....
  79. Neural Control of Vasopressin Release
    J Thomas Cunningham; Fiscal Year: 2013
    ..b>Brain derived neurotrophic factor (BDNF) and its receptor TrkB are expressed by magnocellular neurosecretory cells that secrete ..
  80. MOSES VICTOR CHAO; Fiscal Year: 2015
    ....
  81. THOMAS HARRIS MEEK; Fiscal Year: 2014
    ..Performance of these studies is thereby hoped to inform the development of more effective diabetes treatment strategies. ..
  82. Y S Prakash; Fiscal Year: 2015
    ..Recent studies in adult airway suggest a role for the neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor TrkB in local control of airway structure and ..
  83. Maribel Rios; Fiscal Year: 2014
    ..the adult animal to promote satiety and that the ventromedial hypothalamus (VMH) is a critical source of this neurotrophin. Supportive evidence includes the robust effects of energy status on expression of BDNF and TrkB in the VMH and ..
  84. JULI S WADE; Fiscal Year: 2016
    ..tubulin specific chaperone A (TBCA) and/or tyrosine kinase B (TrkB, the high affinity receptor for brain derived neurotrophic factor - BDNF);(2) These genes and the BDNF ligand modulate masculinization, in part by increasing ..
  85. Italo Mocchetti; Fiscal Year: 2016
    ..are reproduced by the proneurotrophin brain-derived neurotrophic factor (proBDNF) and are mediated by the p75 neurotrophin receptor (p75NTR), a member of the tumor necrosis factor family...
  86. Regulation of microRNA biogenesis by neurotrophins
    CLAUDIA ROXANA RUIZ; Fiscal Year: 2013
    ..The following specific aims will be addressed: 1) Investigate the mechanisms underlying upregulation of the microRNA processing factor, Lin28, by BDNF;2) Determine whether Lin28 levels can be locally controlled at synapses. ..
  87. Mohammad Ali Faghihi; Fiscal Year: 2016
    ..Overall these projects will pave the road for future epigenetic studies on other genomic loci, serving to establish novel noncoding RNA therapeutic targets for several neuropsychological disorders. ..
  88. Heart-Brain Retraining: Forced Aerobic exercise for Stroke Rehabilitation
    SUSAN MARIE LINDER; Fiscal Year: 2013
    ..If forced exercise is shown effective, it could become a viable adjunct to current neurorehabilitation approaches in driving neural recovery while simultaneously improving cardiovascular health. ..
  89. Kim L Huhman; Fiscal Year: 2016
    ..This project will test the overarching hypothesis that brain derived neurotrophic factor (BDNF) systems within specific regions of the CD neural circuit mediate, at least in part, ..
  90. LAURA RHEA WHITEAKER GAINEY; Fiscal Year: 2016
    ..These studies will enhance understanding of hedonic feeding, a component behavior in the etiology of obesity, and thus provide a foundation for the development of therapies to prevent and combat this chronic, debilitating disorder. ..
  91. Gene-Environment Interactions in Loneliness and Stress Reactivity in Older Adults
    Turhan Canli; Fiscal Year: 2013
    ..This work is critical for identifying vulnerable individuals and developing tailored interventions. ..
  92. Respiratory Circuit Dysfunction in Rett Syndrome
    David M Katz; Fiscal Year: 2013
    ..We will also examine how deficits in Brain Derived Neurotrophic Factor (BDNF), a key neuronal signaling molecule whose expression is severely decreased in RTT, contribute ..
  93. Investigating the Role of Muscle-derived BDNF in Neuromuscular Disease Pathology
    ERICH NORSE OTTEM; Fiscal Year: 2011
    ..This project will act as a foundation for research in this unexplored area and enhance biomedical science research opportunities for undergraduate and graduate students at Northern Michigan University. ! ..