BMP2

Summary

Gene Symbol: BMP2
Description: bone morphogenetic protein 2
Alias: BDA2, BMP2A, bone morphogenetic protein 2, bone morphogenetic protein 2A
Species: human

Top Publications

  1. ncbi The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells
    Elaine M Langenfeld
    Department of Surgery, Division of Thoracic Surgery, UMDNJ Robert Wood Johnson Medical School, One Robert Wood Johnson Place, PO Box 19, New Brunswick, NJ 08903 0019, USA
    Carcinogenesis 24:1445-54. 2003
  2. ncbi Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions
    Brian T Feeley
    Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Center for Health Sciences 76 134, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    Bone 38:154-66. 2006
  3. ncbi Chondrogenic differentiation of bovine synovium: bone morphogenetic proteins 2 and 7 and transforming growth factor beta1 induce the formation of different types of cartilaginous tissue
    Nahoko Shintani
    ITI Research Institute for Dental and Skeletal Biology, University of Bern, Bern, Switzerland
    Arthritis Rheum 56:1869-79. 2007
  4. pmc Transforming growth factor β1 inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy?
    Sabrina Ehnert
    BG Trauma Center, Eberhard Karls Universitat Tubingen, Schnarrenbergstr, 95, D 72076, Tubingen, Germany
    BMC Med 10:101. 2012
  5. pmc MicroRNA-208 modulates BMP-2-stimulated mouse preosteoblast differentiation by directly targeting V-ets erythroblastosis virus E26 oncogene homolog 1
    Tomohiro Itoh
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    J Biol Chem 285:27745-52. 2010
  6. pmc WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity
    Mitsuaki Ono
    Craniofacial and Skeletal Diseases Branch, National Institutes of Craniofacial and Dental Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Bone Miner Res 26:193-208. 2011
  7. ncbi USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney
    Motoko Yanagita
    Yanagisawa Orphan Receptor Project, Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Agency, Tokyo 135 0064, Japan
    Biochem Biophys Res Commun 316:490-500. 2004
  8. doi Hypoxia induces BMP-2 expression via ILK, Akt, mTOR, and HIF-1 pathways in osteoblasts
    Wen Pei Tseng
    Graduate Institute of Sports and Health, National Changhua University of Education, Changhua County, Taiwan
    J Cell Physiol 223:810-8. 2010
  9. doi Activation of the PI3K/Akt pathway mediates bone morphogenetic protein 2-induced invasion of pancreatic cancer cells Panc-1
    Xiong Chen
    Department of General Surgery, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People s Republic of China
    Pathol Oncol Res 17:257-61. 2011
  10. doi DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins
    Masao Tanaka
    Division of Hematology and Immunology, Department of Internal Medicine, Kanazawa Medical University, Ishikawa, Japan
    FEBS J 277:4278-89. 2010

Research Grants

  1. LOUIS CHARLES GERSTENFELD; Fiscal Year: 2015
  2. Differential Effects of BMPs on the Healing of Craniofacial Defects
    Russell R Reid; Fiscal Year: 2013
  3. Melissa B Rogers; Fiscal Year: 2015
  4. BMP-2 Regulation of Bone Homeostasis
    Vicki Rosen; Fiscal Year: 2013
  5. Rajaram Gopalakrishnan; Fiscal Year: 2014
  6. Farhad Parhami; Fiscal Year: 2015
  7. Chia Soo; Fiscal Year: 2016
  8. KRISTINA I BOSTROM; Fiscal Year: 2016
  9. ELIZABETH H LACY; Fiscal Year: 2016
  10. Vicki Rosen; Fiscal Year: 2014

Detail Information

Publications239 found, 100 shown here

  1. ncbi The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells
    Elaine M Langenfeld
    Department of Surgery, Division of Thoracic Surgery, UMDNJ Robert Wood Johnson Medical School, One Robert Wood Johnson Place, PO Box 19, New Brunswick, NJ 08903 0019, USA
    Carcinogenesis 24:1445-54. 2003
    ..BMP-2 enhancement of tumor cell migration and invasion, as well as stimulating tumor growth in vivo, suggests it has important biological activity in lung carcinomas...
  2. ncbi Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions
    Brian T Feeley
    Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Center for Health Sciences 76 134, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    Bone 38:154-66. 2006
    ..The role of BMPs in the formation of prostate cancer metastases to bone remains unknown. We hypothesized that BMPs influence the development and progression of osteolytic prostate cancer lesions...
  3. ncbi Chondrogenic differentiation of bovine synovium: bone morphogenetic proteins 2 and 7 and transforming growth factor beta1 induce the formation of different types of cartilaginous tissue
    Nahoko Shintani
    ITI Research Institute for Dental and Skeletal Biology, University of Bern, Bern, Switzerland
    Arthritis Rheum 56:1869-79. 2007
    ....
  4. pmc Transforming growth factor β1 inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy?
    Sabrina Ehnert
    BG Trauma Center, Eberhard Karls Universitat Tubingen, Schnarrenbergstr, 95, D 72076, Tubingen, Germany
    BMC Med 10:101. 2012
    ..Therefore, in the present work we investigated the influence of rhTGFβ1 on rhBMP signaling in primary human osteoblasts, with the aim of more specifically delineating the underlying regulatory mechanisms...
  5. pmc MicroRNA-208 modulates BMP-2-stimulated mouse preosteoblast differentiation by directly targeting V-ets erythroblastosis virus E26 oncogene homolog 1
    Tomohiro Itoh
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    J Biol Chem 285:27745-52. 2010
    ..Taken together, these results suggest that the down-regulation of miR-208 in BMP-2-stimulated osteoblast differentiation is an important part of the regulatory machinery involved in early osteogenesis...
  6. pmc WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity
    Mitsuaki Ono
    Craniofacial and Skeletal Diseases Branch, National Institutes of Craniofacial and Dental Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Bone Miner Res 26:193-208. 2011
    ..stromal cells (BMSCs) were transduced with WISP-1 adenovirus (adWISP-1) in the presence or absence of bone morphogenetic protein 2 (BMP-2) adenovirus (adBMP-2)...
  7. ncbi USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney
    Motoko Yanagita
    Yanagisawa Orphan Receptor Project, Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Agency, Tokyo 135 0064, Japan
    Biochem Biophys Res Commun 316:490-500. 2004
    ..Collectively, we suggest that USAG-1 is a BMP antagonist that interacts with BMP-7 in the developing and adult kidney...
  8. doi Hypoxia induces BMP-2 expression via ILK, Akt, mTOR, and HIF-1 pathways in osteoblasts
    Wen Pei Tseng
    Graduate Institute of Sports and Health, National Changhua University of Education, Changhua County, Taiwan
    J Cell Physiol 223:810-8. 2010
    ..Taken together, our results provide evidence that hypoxia enhances BMP-2 expression in osteoblasts by an HIF-1alpha-dependent mechanism involving the activation of ILK/Akt and mTOR pathways...
  9. doi Activation of the PI3K/Akt pathway mediates bone morphogenetic protein 2-induced invasion of pancreatic cancer cells Panc-1
    Xiong Chen
    Department of General Surgery, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People s Republic of China
    Pathol Oncol Res 17:257-61. 2011
    ..In our studies, we have focused on bone morphogenetic protein 2(BMP-2) because it induces an epithelial to mesenchymal transition (EMT) and accelerates invasion in the ..
  10. doi DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins
    Masao Tanaka
    Division of Hematology and Immunology, Department of Internal Medicine, Kanazawa Medical University, Ishikawa, Japan
    FEBS J 277:4278-89. 2010
    ..e. activin, TGF-β, bone morphogenetic protein 2/4 (BMP-2/4), their receptors and follistatin...
  11. doi Opposing effects of bone morphogenetic protein-2 and endothelin-1 on lung fibroblast chloride currents
    Vadim Shlyonsky
    Physiology Department, Universite Libre de Bruxelles, Brussels, Belgium
    Am J Respir Cell Mol Biol 45:1154-60. 2011
    ..The application of BMP2 prevented activation of these currents by hypotonic challenge in a time- and dose-dependent manner, partially via ..
  12. ncbi BMP2 induces PANC-1 cell invasion by MMP-2 overexpression through ROS and ERK
    Jun Liu
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, China
    Front Biosci (Landmark Ed) 17:2541-9. 2012
    ..We hypothesized that BMP2 promotes cancer metastasis by modulating MMP-2 secretion and activity through intracellular ROS regulation and ERK ..
  13. pmc Downregulation of bone morphogenetic protein receptor axis during HIV-1 and cocaine-mediated pulmonary smooth muscle hyperplasia: implications for HIV-related pulmonary arterial hypertension
    Pranjali Dalvi
    Division of Pulmonary and Critical Care Medicine, Department of Medicine P D, A O B L, N K D and Department of Molecular and Integrative Physiology N K D, University of Kansas Medical Center, Kansas City, KS
    Arterioscler Thromb Vasc Biol 33:2585-95. 2013
    ..We now examined the role of antiproliferative bone morphogenetic protein receptor (BMPR) axis in HIV protein and cocaine-mediated pulmonary smooth muscle hyperplasia...
  14. ncbi Bone morphogenetic protein (BMP)-7 but not BMP-2 and BMP-4 improves maintenance of primitive peripheral blood-derived hematopoietic progenitor cells (HPC) cultured in serum-free medium supplemented with early acting cytokines
    Jochen Grassinger
    Department of Hematology and Oncology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Cytokine 40:165-71. 2007
    ..However, BMP-7 but not BMP-2 and BMP-4 prevents the loss of primitive hematopoietic progenitor cells cultured in SFM plus SF3...
  15. ncbi Apoptosis induction and reduced proliferation in human osteoblasts by rhBMP-2, -4 and -7
    O P Gautschi
    Department of Orthopaedic and Trauma Surgery, Royal Perth Hospital, Perth, Western Australia, Australia
    J Musculoskelet Neuronal Interact 9:53-60. 2009
    ..There are, however, contradictory reports of BMPs causing apoptosis and inhibition of proliferation of osteoblastic cells. Therefore, a more complete understanding of the effects of BMP-2, -4 and -7 on human osteoblasts is required...
  16. ncbi Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins
    N W Morrell
    Department of Medicine, University of Cambridge, Addenbrooke s and Papworth Hospitals, Cambridge, United Kingdom
    Circulation 104:790-5. 2001
    ..We postulated that pulmonary artery smooth muscle cells (PASMCs) from patients with PPH might demonstrate abnormal growth responses to TGF-beta superfamily members...
  17. ncbi Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon
    James C H Hardwick
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 126:111-21. 2004
    ..We investigated the role of BMP2 in the colon.
  18. pmc Proliferative activity of extracellular HIV-1 Tat protein in human epithelial cells: expression profile of pathogenetically relevant genes
    Alessia A Bettaccini
    Dipartimento di Scienze Cliniche e Biologiche, Universita dell Insubria, Varese, Italy
    BMC Microbiol 5:20. 2005
    ..The activity of two-exon (aa 1-101) and synthetic (aa 1-86) Tat was studied on mammary and amniotic epithelial cells cultured under low serum conditions...
  19. pmc Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation
    Julie B Sneddon
    Department of Biochemistry, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:14842-7. 2006
    ..Our data suggest that BMP antagonists may be important constituents of tumor stroma, providing a favorable microenvironment for cancer cell survival and expansion in many cancers...
  20. doi Investigation of the association of BMP gene variants with nephropathy in Type 1 diabetes mellitus
    A J McKnight
    Nephrology Research Group, Queen s University of Belfast, Belfast, UK
    Diabet Med 27:624-30. 2010
    ..The BMP2, BMP4 and BMP7 genes are located near linkage peaks for renal dysfunction, and we hypothesize that genetic ..
  21. doi Complement regulator-acquiring surface protein 1 of Borrelia burgdorferi binds to human bone morphogenic protein 2, several extracellular matrix proteins, and plasminogen
    Teresia Hallström
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    J Infect Dis 202:490-8. 2010
    ..burgdorferi that binds to several human extracellular matrix proteins and plasminogen. These interactions may contribute to adhesion, bacterial colonization, and organ tropism and may allow dissemination of B. burgdorferi in the host...
  22. doi WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity
    György Szláma
    Institute of Enzymology, Budapest, Hungary
    FEBS J 277:5040-50. 2010
    ..significance of these interactions we studied the effect of WFIKKN proteins on the activity of GDF8, GDF11, TGFβ1, BMP2 and BMP4 using reporter assays...
  23. ncbi Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily
    T K Sampath
    Creative BioMolecules, Inc, Hopkinton, Massachusetts 01748
    J Biol Chem 265:13198-205. 1990
    ..The 18-kDa subunit is the protein product of the bovine equivalent of the human OP-1 gene and the 16-kDa subunit is the protein product of the bovine equivalent of the human BMP-2A gene...
  24. ncbi BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1
    M K Majumdar
    Genetics Institute, Inc, Cambridge, Massachusetts 02140, USA
    J Cell Physiol 189:275-84. 2001
    ..This study shows that bone morphogenetic proteins play an important role in chondrogenesis and may prove to be potential therapeutics in cartilage repair...
  25. doi Enhancement of bone morphogenetic protein-2-induced ectopic bone formation by transforming growth factor-β1
    Keita Tachi
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    Tissue Eng Part A 17:597-606. 2011
    ..Our findings may contribute to the development of a new treatment method for skeletal disorders...
  26. doi Endoglin is involved in BMP-2-induced osteogenic differentiation of periodontal ligament cells through a pathway independent of Smad-1/5/8 phosphorylation
    Osamu Ishibashi
    Department of Molecular Anatomy and Medicine, Nippon Medical School, Tokyo, Japan
    J Cell Physiol 222:465-73. 2010
    ..These results, taken together, raise a possibility that PDL cells respond to BMP-2 via a unique signaling pathway dependent on endoglin, which is involved in the osteoblastic differentiation and mineralization of the cells...
  27. ncbi Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation
    Hiroyuki Otani
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Japan
    Am J Physiol Renal Physiol 292:F1513-25. 2007
    ....
  28. ncbi Crystal structure of the BMP-2-BRIA ectodomain complex
    T Kirsch
    Physiologische Chemie II, Biozentrum der Universität Würzburg, Germany
    Nat Struct Biol 7:492-6. 2000
    ..No contacts exist between the receptor domains. The model reveals the structural basis for discrimination between type I and type II receptors and the variability of receptor-ligand interactions that is seen in BMP-TGF-beta systems...
  29. ncbi Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome
    Alexander Kotzsch
    Lehrstuhl für Botanik I Molekulare Pflanzenphysiologie und Biophysik, Julius von Sachs Institut der Universität Würzburg, Julius von Sachs Platz 2, D 97082 Wurzburg, Germany
    J Biol Chem 283:5876-87. 2008
    ....
  30. pmc Association of bone morphogenetic protein-2 gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity in Chinese patients
    Hao Wang
    Beijing Tiantan Hospital, Capital Medical University CMU, Beijing, 100050, China
    Eur Spine J 17:956-64. 2008
    ..The "G" allele in the Ser87Ser (A/G) polymorphism promotes the extent of OPLL, whereas the "A" allele in the Ser87Ser (A/G) polymorphism restricts ectopic ossification in the cervical spine at least in Chinese subjects...
  31. doi The positive correlation between gene expression of the two angiogenic factors: VEGF and BMP-2 in lung cancer patients
    Magdalena Bieniasz
    Department of Medical Biochemistry, Medical University of Lodz, 6 8 Mazowiecka, Lodz 92215, Poland
    Lung Cancer 66:319-26. 2009
    ..In conclusion, our findings underline the importance of the two angiogenic factors namely VEGF and BMP-2 as well as +936C/T VEGF gene polymorphism in the evaluation of lung cancer patients...
  32. pmc Expression of bone morphogenetic protein-2 and its receptors in epithelial ovarian cancer and their influence on the prognosis of ovarian cancer patients
    Ying Ma
    Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004, China
    J Exp Clin Cancer Res 29:85. 2010
    ..To determine the expression of bone morphogenetic protein-2 (BMP-2) and its receptors BMPRIA, BMPRIB, and BMPRII in epithelial ovarian cancer (EOC) and to analyze their influence on the prognosis of ovarian cancer patients...
  33. doi The serum bone morphogenetic protein-2 level in non-small-cell lung cancer patients
    Yoon Ji Choi
    Divisions of Hematology Oncology, Department of Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126 1, Anam Dong 5 Ga, Seongbul gu, Seoul 136 705, South Korea
    Med Oncol 29:582-8. 2012
    ..59.6% versus 40.2%, P = 0.034). The serum BMP-2 level is positively correlated with the stage and metastatic burden and maybe a probable predictor of survival in the NSCLC patients...
  34. doi BMP induced inflammation: a comparison of rhBMP-7 and rhBMP-2
    Kwang Bok Lee
    Department of Orthopaedic Surgery, University of California, UCLA Comprehensive Spine Center, 1250 16th Street 7th Floor Tower, No 745, Santa Monica, Los Angeles, California 90404, USA
    J Orthop Res 30:1985-94. 2012
    ..Our animal model can be used to test materials that could ameliorate this reaction...
  35. pmc Recombinant human bone morphogenetic protein induces bone formation
    E A Wang
    Genetics Institute, Cambridge, MA 02140
    Proc Natl Acad Sci U S A 87:2220-4. 1990
    ..The cartilage- and bone-inductive activity of the recombinant BMP-2A is histologically indistinguishable from that of bone extracts. Thus, recombinant BMP-2A has therapeutic potential to promote de novo bone formation in humans...
  36. ncbi Novel regulators of bone formation: molecular clones and activities
    J M Wozney
    Tissue Growth and Repair Program, Genetics Institute, Inc, Cambridge, MA 02140
    Science 242:1528-34. 1988
    ..Two of the encoded proteins (BMP-2A and BMP-3) are new members of the TGF-beta supergene family, while the third, BMP-1, appears to be a novel regulatory molecule...
  37. pmc Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs
    F Liu
    Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 15:3479-86. 1995
    ..The combinatorial nature of these receptors and their capacity to crosstalk with the activin receptor system may underlie the multifunctional nature of their ligands...
  38. ncbi Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4
    P ten Dijke
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    J Biol Chem 269:16985-8. 1994
    ..These results suggest that ALK-3 and ALK-6 are type I receptors for OP-1 and BMP-4; in addition, ALK-2 is a type I receptor shared by activin and OP-1, but not by BMP-4...
  39. ncbi Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development
    Y Furuta
    Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Development 124:2203-12. 1997
    ..compared by in situ hybridization the expression of five Bmp genes belonging to the Drosophila Decapentaplegic (Bmp2 and Bmp4) and 60A subgroups (Bmp5, Bmp6 and Bmp7)...
  40. ncbi Bone morphogenetic protein-2 and transforming growth factor-beta2 interact to modulate human bone marrow stromal cell proliferation and differentiation
    O Fromigue
    INSERM Unit 349, Cell and Molecular Biology of Bone and Cartilage, Lariboisiere Hospital, Paris, France
    J Cell Biochem 68:411-26. 1998
    ..These observations suggest that TGF-beta2 and BMP-2 may act in a sequential manner at different stages to promote human bone marrow stromal cell differentiation towards the osteoblast phenotype...
  41. ncbi Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo
    J Kleeff
    Division of Endocrinology, Diabetes and Metabolism, Departments of Medicine, Biological Chemistry and Pharmacology, University of California, Irvine, California, USA
    Gastroenterology 116:1202-16. 1999
    ..We characterized the expression of BMP-2 and its receptors in human pancreatic tissues and pancreatic cancer cell lines and examined the effects of BMP-2 on mitogenesis...
  42. ncbi Isolation of recombinant BMP receptor IA ectodomain and its 2:1 complex with BMP-2
    T Kirsch
    Physiologische Chemie II, Biozentrum der Universität Würzburg, Am Hubland, D 97074, Wurzburg, Germany
    FEBS Lett 468:215-9. 2000
    ....
  43. pmc Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors
    L Gilboa
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Biol Cell 11:1023-35. 2000
    ..This novel feature in the oligomerization mode of the BMP receptors allows higher variety and flexibility in their responses to various ligands as compared with the TGF-beta receptors...
  44. ncbi Effects of bone morphogenetic protein-2 on human tumor cell growth and differentiation: a preliminary report
    H Orui
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    J Orthop Sci 5:600-4. 2000
    ..The results of this study may suggest the feasibility of using rhBMP-2 for the reconstruction of bone defects caused by malignant tumors, although the data are still preliminary and require further investigation...
  45. ncbi Bone morphogenetic protein-2 and type IV collagen expression in psammoma body forming ovarian cancer
    Y Kiyozuka
    Department of Pathology II, Kansai Medical University, Moriguchi, Osaka, Japan
    Anticancer Res 21:1723-30. 2001
    ..These results raise the possibility that BMP-2 and type IV collagen-producing slow growing tumor cells form PBs in ovarian cancer...
  46. ncbi Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells
    Chung Fang Lai
    Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:15514-22. 2002
    ..Thus, ERK and p38 differentially mediate TGF-beta and BMP-2 function in osteoblasts...
  47. ncbi Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells
    Chiharu Kawamura
    Division of Hematology, Keio University School of Medicine, Tokyo, Japan
    Leuk Lymphoma 43:635-9. 2002
    ..In this review, we summarize data concerning BMPs and BMP-2-induced apoptosis of myeloma cells including our own recent experimental data...
  48. ncbi Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling
    P J Marie
    INSERM U349, Hopital Lariboisiere, Paris, France
    Histol Histopathol 17:877-85. 2002
    ....
  49. ncbi BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels
    Kristin A Waite
    Clinical Cancer Genetics Program, Comprehensive Cancer Center, Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH, 43210, USA
    Hum Mol Genet 12:679-84. 2003
    ..We thus sought to determine whether BMP2 stimulation alters PTEN protein levels in the breast cancer line, MCF-7...
  50. ncbi BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect
    Andrew R Hallahan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nat Med 9:1033-8. 2003
    ....
  51. ncbi Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes
    Naoshi Fukui
    J Bone Joint Surg Am 85:59-66. 2003
    ..While a great deal is known about catabolism, we sought to determine the biochemical basis of the anabolic activity...
  52. ncbi Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis
    Rik J U Lories
    Katholieke Universiteit Leuven, Leuven, Belgium
    Arthritis Rheum 48:2807-18. 2003
    ..To examine the expression, regulation, and potential roles of bone morphogenetic proteins (BMPs) in arthritic synovium...
  53. pmc Linkage of osteoporosis to chromosome 20p12 and association to BMP2
    Unnur Styrkarsdottir
    deCODE Genetics, Reykjavik, Iceland
    PLoS Biol 1:E69. 2003
    ..Three variants in the bone morphogenetic protein 2 (BMP2) gene, a missense polymorphism and two anonymous single nucleotide polymorphism haplotypes, were ..
  54. ncbi Bone morphogenetic protein-2 stimulates angiogenesis in developing tumors
    Elaine M Langenfeld
    Department of Surgery, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903 0019, USA
    Mol Cancer Res 2:141-9. 2004
    ..This study reveals that BMP-2 enhanced the angiogenic response in developing tumors. Furthermore, these data suggest that BMP-2 stimulation of angiogenesis may involve the activation of endothelial cells...
  55. ncbi Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression
    Lisa G Horvath
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, Sydney, NSW, Australia
    Prostate 59:234-42. 2004
    ..This study aimed to characterize aspects of the BMP pathway in PC by assessing BMP2, Smad8, and Smad4 expression in normal, hyperplastic, and malignant prostate tissue, and to correlate findings with ..
  56. ncbi Molecular recognition of BMP-2 and BMP receptor IA
    Sascha Keller
    Lehrstuhl für Physiologische Chemie II, Theodor Boveri Institut für Biowissenschaften Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wuerzburg, Germany
    Nat Struct Mol Biol 11:481-8. 2004
    ..Thus, the L51P substitution converts BMP-2 into a receptor-inactive inhibitor of noggin. These results are relevant for other proteins of the TGF-beta superfamily and provide useful clues for structure-based drug design...
  57. ncbi Conservation of Bmp2 post-transcriptional regulatory mechanisms
    David T Fritz
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey UMDNJ NJ Medical School, Newark, New Jersey 07101, USA
    J Biol Chem 279:48950-8. 2004
    ..A 265-nucleotide sequence, conserved between mammals, birds, frogs, and fish, is present in Bmp2 but not Bmp4...
  58. ncbi Bone morphogenetic proteins
    Di Chen
    School of Medicine and Dentistry, Department of Orthopaedics, University of Rochester, Rochester, NY 14642, USA
    Growth Factors 22:233-41. 2004
    ..A. et al. (1996) "MADR1, a MAD-related protein that functions in BMP2 signaling pathways", Cell 85, 489-500; Chen Y. et al...
  59. ncbi Use of bone morphogenetic protein 2 and diffusion chambers to engineer cartilage tissue for the repair of defects in articular cartilage
    Masashi Nawata
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Arthritis Rheum 52:155-63. 2005
    To examine the ability of cartilage-like tissue, generated ectopically in a diffusion chamber using recombinant human bone morphogenetic protein 2 (rHuBMP-2), to repair cartilage defects in rats.
  60. ncbi Alphavbeta integrins play an essential role in BMP-2 induction of osteoblast differentiation
    Chung Fang Lai
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Bone Miner Res 20:330-40. 2005
    ..BMP-2 stimulates alphavbeta expression. BMP-2 receptors co-localize/overlap with alphavbeta integrins, and the intact function of alphavbeta is essential in BMP-2 activity...
  61. ncbi Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses
    Sabine Mazerbourg
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, California 94305 5317, USA
    J Biol Chem 280:32122-32. 2005
    ..Thus, the present approach provides a genomic paradigm for matching paralogous polypeptide ligands with a limited number of evolutionarily related receptors capable of activating specific downstream Smad proteins...
  62. ncbi Cross-talk between Wnt and bone morphogenetic protein 2 (BMP-2) signaling in differentiation pathway of C2C12 myoblasts
    Aiko Nakashima
    Department of Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan
    J Biol Chem 280:37660-8. 2005
    ..We examined a potential role for Wnt signaling and functional cross-talk of bone morphogenetic protein 2 (BMP-2) in osteoblast differentiation...
  63. ncbi Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5
    E M Langenfeld
    Division of Thoracic Surgery, Department of Surgery, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903 0019, USA
    Oncogene 25:685-92. 2006
    ..We provide evidence that BMP-2 promotes tumor growth. This paper highlights that cell culture experiments may not reveal the full biological affects of BMP-2, and its activity varies depending of the local environment...
  64. ncbi BMP-2 prevents apoptosis of the N1511 chondrocytic cell line through PI3K/Akt-mediated NF-kappaB activation
    Kazuhito Sugimori
    Department of Orthopaedic Surgery, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Bone Miner Metab 23:411-9. 2005
    ..These data indicate that BMP-2 can utilize a new signal transduction pathway in the NF-kappaB activation system, which plays a crucial role in the survival of the N1511 chondrocytic cell line...
  65. ncbi Alteration of gene expression in response to bone morphogenetic protein-2 in androgen-dependent human prostate cancer LNCaP cells
    Toru Kumagai
    Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba 278 8510, Japan
    Int J Mol Med 17:285-91. 2006
    ..Further studies of the roles of these genes may clarify the mechanisms underlying the inhibition of cell proliferation by BMP-2 and identify better approaches for the prevention and treatment of prostate cancer...
  66. ncbi Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women
    Ana M Valdes
    St Thomas Hospital, London, UK
    Arthritis Rheum 54:533-9. 2006
    ....
  67. ncbi A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells
    Zhongyu Liu
    Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Biol Chem 281:17156-63. 2006
    ..These results identify a potential mechanism whereby BMP-2 antagonizes Wnt signaling in osteoblast progenitors by promoting an interaction between Smad1 and Dvl-1 that restricts beta-catenin activation...
  68. pmc Structure of the ternary signaling complex of a TGF-beta superfamily member
    George P Allendorph
    Structural Biology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:7643-8. 2006
    The crystal structure of the complete signaling complex formed between bone morphogenetic protein 2 (BMP-2) and the extracellular domains (ECDs) of its type I receptor [bone morphogenetic protein receptor type Ia (BMPR-Ia)-ECD] and its ..
  69. pmc Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury
    Francesco Dell'accio
    Department of Rheumatology, King s College London, London, UK
    Arthritis Res Ther 8:R139. 2006
    ..b>Bone morphogenetic protein 2 (BMP-2) mRNA was upregulated in the injured explants...
  70. ncbi BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway
    Eun Jung Jin
    Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu 702 701, Korea
    Mol Cells 22:353-9. 2006
    ..Our results collectively indicate that the increase in Sox9 protein resulting from downregulation of b-catenin/Wnt-7a signaling is mediated by p38 MAPK during BMP-2 induced chondrogenesis in chick wing bud mesenchymal cells...
  71. ncbi Osteogenic differentiation of human mesenchymal stem cells in collagen matrices: effect of uniaxial cyclic tensile strain on bone morphogenetic protein (BMP-2) mRNA expression
    Ruwan D Sumanasinghe
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695 7115, USA
    Tissue Eng 12:3459-65. 2006
    ..Induction of bone differentiation in 3D culture is a critical step in the creation of bioengineered bone constructs...
  72. ncbi STRO-1 selected rat dental pulp stem cells transfected with adenoviral-mediated human bone morphogenetic protein 2 gene show enhanced odontogenic differentiation
    Xuechao Yang
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Tissue Eng 13:2803-12. 2007
    ..Results of ALP activity, calcium content, and real-time PCR showed that only BMP2-transfected cells had the ability to differentiate into the odontoblast phenotype and to produce a calcified ..
  73. pmc BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells
    Karen Lavery
    Stryker Biotech, 35 South Street, Hopkinton, MA 01748, USA
    J Biol Chem 283:20948-58. 2008
    ..These results suggest different mechanisms for BMP-2/4- and BMP-6/7-induced osteoblastic differentiation in primary hMSC...
  74. doi Osteoblasts-derived BMP-2 enhances the motility of prostate cancer cells via activation of integrins
    Tzu Hsiu Lai
    Department of Pharmacology, China Medical University, Taichung, Taiwan
    Prostate 68:1341-53. 2008
    ..The aim of this study was to investigate whether osteoblast-derived BMP-2 is associated with prostate cancer metastasis...
  75. doi BMP-2 increases migration of human chondrosarcoma cells via PI3K/Akt pathway
    Yi Chin Fong
    Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan
    J Cell Physiol 217:846-55. 2008
    ..Taken together, these results suggest that the BMP-2 acts through PI3K/Akt, which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activations of beta1 integrin and contributing the migration of human chondrosarcoma cells...
  76. doi The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding
    Jochen Klages
    Center of Integrated Protein Science CIPSM at the Technische Universitat Munchen, Lichtenbergstrasse 4, D 85747 Garching, Germany
    Biochemistry 47:11930-9. 2008
    ..The inherent flexibility of both partners possibly explains the promiscuous ligand-receptor interaction observed in the BMP protein superfamily...
  77. pmc Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways
    Vinicio A de Jesus Perez
    Department of Medicine, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 184:83-99. 2009
    ..These findings suggest that the recruitment of both canonical and noncanonical Wnt pathways is required in BMP-2-mediated angiogenesis...
  78. pmc Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity
    Alexander Kotzsch
    Lehrstuhl für Botanik I Molekulare Pflanzenphysiologie und Biophysik, Julius von Sachs Institut für Biowissenschaften Biozentrum der Universität Würzburg, Wurzburg, Germany
    EMBO J 28:937-47. 2009
    ..The new structural data now provide also a molecular basis of how phenotypically relevant missense mutations in GDF-5 might impair receptor binding and activation...
  79. pmc Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2
    Katarina Dathe
    Institut fur Medizinische Genetik, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany
    Am J Hum Genet 84:483-92. 2009
    ..3 that incorporates the gene for Bone morphogenetic protein 2 (BMP2)...
  80. pmc Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer
    Andre F Steinert
    Orthopaedic Center for Musculoskeletal Research, Orthopaedic Clinic, König Ludwig Haus, Julius Maximilians University, Brettreichstrasse 11, 97074 Wurzburg, Germany
    Arthritis Res Ther 11:R148. 2009
    ..The present study compares bone morphogenetic protein (BMP)-4 and BMP-2 gene transfer as agents of chondrogenesis and hypertrophy in human primary mesenchymal stem cells (MSCs) maintained as pellet cultures...
  81. doi The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding
    Anja Hauburger
    Institut für Biochemie und Biotechnologie, Martin Luther Universitat Halle Wittenberg, Germany
    FEBS J 276:6386-98. 2009
    ..The data presented here suggest that the pro-domain of BMP-2 can alter the signalling properties of the growth factor by modulating the ability of the mature part to interact with the receptors...
  82. doi BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway
    Myoung Hee Kang
    Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136 705, Korea
    Exp Cell Res 316:24-37. 2010
    ....
  83. doi Bone morphogenetic protein-2 levels are elevated in the patients with gastric cancer and correlate with disease progression
    Yong Park
    Division of Hematology Oncology, Department of Internal Medicine, College of Medicine, Korea University, Guro Hospital, 80 Guro dong, Guro Gu, Seoul, 152 703, Korea
    Med Oncol 27:1192-9. 2010
    ..In conclusion, serum BMP-2 is associated with progression from early localized gastric cancer to locally advanced gastric cancer...
  84. pmc Bone morphogenetic protein 2 stimulates endochondral ossification by regulating periosteal cell fate during bone repair
    Yan Yiu Yu
    Department of Orthopaedic Surgery, University of California at San Francisco, San Francisco General Hospital, 2550 23rd St, San Francisco, CA 94110, USA
    Bone 47:65-73. 2010
    ..The aim of this study was to define the role of BMP2 during the early stages of bone regeneration and more specifically in regulating the fate of skeletal progenitors...
  85. pmc Association between expression of the bone morphogenetic proteins 2 and 7 in the repair of circumscribed cartilage lesions with clinical outcome
    Hagen Schmal
    Department of Orthopedic Surgery, University of Freiburg Medical Center, Hugstetter Str 55, D 79106 Freiburg, Germany
    BMC Musculoskelet Disord 11:170. 2010
    ..Although there is much known about the role of BMPs in cartilage metabolism reliable data about the in vivo regulation in natural and surgically induced cartilage repair are still missing...
  86. pmc RUNX2 polymorphisms associated with OPLL and OLF in the Han population
    Yang Liu
    Orthopedics Department of Changzheng Hospital, 415 Fengyang Road, Shanghai, 200003, China
    Clin Orthop Relat Res 468:3333-41. 2010
    ....
  87. pmc High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo
    Janette N Zara
    Department of Bioengineering, University of California, Los Angeles, California, USA
    Tissue Eng Part A 17:1389-99. 2011
    ..In this study, we evaluated multiple BMP2 doses in a rat femoral segmental defect model and in a minimally traumatic rat femoral onlay model to determine its ..
  88. doi Retinoic acid receptor γ-dependent signaling cooperates with BMP2 to induce osteoblastic differentiation of C2C12 cells
    Takeo Karakida
    Department of Biochemistry, School of Dental Medicine, Tsurumi University, Yokohama, Japan
    Connect Tissue Res 52:365-72. 2011
    All-trans retinoic acid and bone morphogenetic protein 2 (BMP2) synergistically induced an alkaline phosphatase (ALP) activity, one of the osteoblastic differentiation markers, and promoted the extracellular matrix calcification in a ..
  89. pmc BMP2 protein regulates osteocalcin expression via Runx2-mediated Atf6 gene transcription
    Won Gu Jang
    Dental Science Research Institute and BK21, School of Dentistry, Chonnam National University, Gwangju 500 757, Republic of Korea
    J Biol Chem 287:905-15. 2012
    b>Bone morphogenetic protein 2 (BMP2) activates unfolded protein response (UPR) transducers, such as PERK and OASIS, in osteoblast cells. ATF6, a bZIP transcription factor, is also a UPR transducer...
  90. ncbi A single nucleotide polymorphism in the human bone morphogenetic protein-2 gene (109T > G) affects the Smad signaling pathway and the predisposition to ossification of the posterior longitudinal ligament of the spine
    Liang Yan
    Department of Spine Surgery, Hong Hui Hospital, Xi an Jiaotong University College of Medicine, Xi an, Shaanxi 710054, China
    Chin Med J (Engl) 126:1112-8. 2013
    ..The purpose of this study was to investigate whether bone morphogenetic protein (BMP)-2 is a candidate gene to modify the susceptibility of OPLL and the mechanism of signal transduction in ossification...
  91. doi Inhibition of BMP activity protects epithelial barrier function in lung injury
    Thomas Helbing
    Cardiology and Angiology I, Heart Centre, Freiburg University, Freiburg, Germany
    J Pathol 231:105-16. 2013
    ..Here we studied bone morphogenetic protein (BMP) signalling and, in particular, the role of BMP2 and the BMP modulator BMPER in injured lung epithelium...
  92. doi Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression
    Bastien Laperrousaz
    Centre National de la Recherche Scientifique Unité Mixte de Recherche UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
    Blood 122:3767-77. 2013
    ..Bone morphogenetic proteins 2 (BMP2) and 4 (BMP4) regulate the fate and proliferation of normal hematopoietic stem cells, as well as interactions with ..
  93. ncbi Serum BMP-2 up-regulation as an indicator of poor survival in advanced non-small cell lung cancer patients
    Zheng Hua Fei
    the Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, China E mail
    Asian Pac J Cancer Prev 14:5293-9. 2013
    ..This study was conducted to assess correlations between serum BMP-2 levels and prognostic outcome in patients with non-small-cell lung cancer (NSCLC)...
  94. ncbi A kinase-inactive type II TGFbeta receptor impairs BMP signaling in human breast cancer cells
    Nancy Dumont
    Department of Cancer Biology, Vanderbilt University School of Medicine, 2220 Pierce Avenue, 777 Preston Research Building, Nashville, TN 37232 6307, USA
    Biochem Biophys Res Commun 301:108-12. 2003
    ..In this letter, we report that expression of dnTbetaRII also impairs BMP2-mediated Smad1 phosphorylation as well as BMP2-mediated Smad-dependent transcriptional responses, resulting in an ..
  95. doi Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2
    Xiaoping Yang
    Division of Cardiothoracic Surgery, Department of Surgery, University of Colorado Denver, Aurora, Colo, USA
    J Thorac Cardiovasc Surg 138:1008-15. 2009
    ....
  96. ncbi Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution
    C Scheufler
    Physiological Chemistry II, University of Wurzburg, Wurzburg, 97074, Germany
    J Mol Biol 287:103-15. 1999
    ..The possible function of these specific features in the interaction of BMP-2 with its binding partners is discussed...
  97. ncbi An in vitro and in vivo analysis of fibrin glue use to control bone morphogenetic protein diffusion and bone morphogenetic protein-stimulated bone growth
    Vikas V Patel
    The Spine Institute at St John s Hospital, 1301 20th Street, Suite 400, Santa Monica, CA 90404, USA
    Spine J 6:397-403; discussion 404. 2006
    Recombinant human bone morphogenetic protein-2 (rh-BMP2) has become popular for augmenting spine fusion in the lumbar and cervical spine...
  98. ncbi A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ
    Y Zhang
    Department of Cell and Molecular Biology, Molecular and Cell Biology Graduate Program, Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
    Development 127:1431-43. 2000
    ..Among them are Sonic hedgehog (SHH), Bone Morphogenetic Protein-2 (BMP2) and Bone Morphogenetic Protein-4 (BMP4)...
  99. ncbi Bone morphogenetic protein gene therapy using a fibrin scaffold for a rabbit spinal-fusion experiment
    Tao Chen Lee
    Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    Neurosurgery 58:373-80; discussion 373-80. 2006
    ..To observe the feasibility of using fibrin gel as a scaffold during rabbit spinal fusion with rat kidney cells carrying bone morphogenetic protein-2 (BMP-2) expression vector...
  100. doi Bone morphogenetic protein 6 (BMP6) and BMP7 inhibit estrogen-induced proliferation of breast cancer cells by suppressing p38 mitogen-activated protein kinase activation
    Mina Takahashi
    Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama City 700 8558, Japan
    J Endocrinol 199:445-55. 2008
    ..Treatment with BMPs and activin had no effects on MCF-7 cell proliferation. However, BMP2, BMP4, BMP6, BMP7, and activin suppressed estradiol-induced cell mitosis, with the effects of BMP6, BMP7, and ..
  101. doi Human adipose-derived stromal cells respond to and elaborate bone morphogenetic protein-2 during in vitro osteogenic differentiation
    Nicholas J Panetta
    Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, Calif 94305 5148, USA
    Plast Reconstr Surg 125:483-93. 2010
    ....

Research Grants65

  1. LOUIS CHARLES GERSTENFELD; Fiscal Year: 2015
    ..Inadequate blood supply is a major cause of impaired healing in all types of orthopedic treatments. Bone morphogenetic protein 2 (BMP2) plays an essential role in promoting mesenchymal stem cell (MSC) osteogenic differentiation;..
  2. Differential Effects of BMPs on the Healing of Craniofacial Defects
    Russell R Reid; Fiscal Year: 2013
    ..This project is based on the hypothesis that there is a definable, differential profile of the osteogenic BMPs (BMP2, 4, 6, 7, 9) in regards to their capacity to induce healing of critical-sized craniofacial defects...
  3. Melissa B Rogers; Fiscal Year: 2015
    ..b>Bone morphogenetic protein 2 (BMP2) is a key signal in valve development...
  4. BMP-2 Regulation of Bone Homeostasis
    Vicki Rosen; Fiscal Year: 2013
    ..Our recent data showing that loss of BMP2 from the limb skeleton leads to pervasive spontaneous fractures in the postnatal mice (Tsuji et al...
  5. Rajaram Gopalakrishnan; Fiscal Year: 2014
    ..Further, we show that exogenous BMP2 increases pSmad1/5/8 levels in WT osteoclasts and also enhances RANKL stimulated osteoclast differentiation...
  6. Farhad Parhami; Fiscal Year: 2015
    ..in oxysterol effects in vivo;and 3) Examine the role of baseline and oxysterol-induced Hh pathway activity in BMP2-induced osteogenesis by determining whether Hh signaling through Gli transcription factors mediates the synergy ..
  7. Chia Soo; Fiscal Year: 2016
    ..2 million surgical cases each year. Bone morphogenetic protein 2 (BMP2), the main growth factor for bone regeneration, has significant adverse effects at the FDA ..
  8. KRISTINA I BOSTROM; Fiscal Year: 2016
    ..Matrix Gla protein (MGP) is an inhibitor of vascular calcification, and an antagonist to BMP2/4. MGP null mice show strong activation of vascular BMP signaling and extensive aortic calcification...
  9. ELIZABETH H LACY; Fiscal Year: 2016
    ..b>BMP2 expressed by the AVE signals to epiblast derivatives during gastrulation to orchestrate the initial stages of ..
  10. Vicki Rosen; Fiscal Year: 2014
    ..Paradoxically, too much BMP activity is also associated with OA (18-20). In this proposal, we focus on BMP2 and examine its role in maintaining postnatal synovial joint function...
  11. Audrey Rakian; Fiscal Year: 2016
    ..is regulated by many signaling molecules and growth factors, including the critical role played by bone morphogenetic protein 2 (Bmp2)...
  12. David J Goldhamer; Fiscal Year: 2014
    ..HO will be induced by intramuscular injection of BMP2, and the contribution of labeled cell populations to heterotopic cartilage and bone determined by ..
  13. Bmp-signaling in craniofacial development
    JAMES FRANCIS MARTIN; Fiscal Year: 2012
    ..of Bmp signaling in craniofacial morphogenesis has been limited by the early embryonic lethality of the Bmp4 and Bmp2 null mutant mice...
  14. Heparan sulfate-dependent mechanisms of skeletogenesis
    Julianne Huegel; Fiscal Year: 2012
    ..deficiency markedly increased chondrogenic differentiation and responsiveness to pro-chondrogenic factors such as BMP2. Additionally, studies by others showed that expression of HS-degrading enzyme heparanase (HPSE) is high in ..
  15. JONATHAN KYLE POKORSKI; Fiscal Year: 2014
    ..The peptide affinity tags identified in the mentored phase will be fused to bone morphogenetic protein 2 (BMP2) at one or both termini, and act as nucleation sites for gel fibril formation...
  16. Giuseppe Intini; Fiscal Year: 2014
    ..In contrast, mice lacking BMP2 are unable to maintain adequate bone formation after birth and suffer of spontaneous fractures that do not resolve ..
  17. Min Lee; Fiscal Year: 2015
    ..protein that can be delivered extracellularly, and most importantly Nell-1 promotes synergistic effects with BMP2 on bone regeneration...
  18. Muscle-based Tissue Engineering to Improve Bone Healing
    Johnny Huard; Fiscal Year: 2010
    ..l skeleton is common. Osteogenic proteins, including bone morphogenetic protein 2 and 4 (BMP2, BMP4), promote healing in bone defects, but the proteins'short half-lives and rapid ..
  19. Divergence and maturation of autonomic lineages
    SUSAN BIRREN; Fiscal Year: 2009
    ..We will test the hypothesis that BMP2 promotes neuronal differentiation by maintaining a pool of uncommitted precursor cells at the expense of glial ..
  20. Role and Mechanism of Bone Morphogenetic Protein 2 Action During Dentinogenesis
    Wuchen Yang; Fiscal Year: 2010
    ..b>Bone Morphogenetic Protein 2 (BMP2) has been suggested to play a central and crucial role throughout the entire stages of ..
  21. Role of the BMP co-receptor Dragon (RGMb) in ovarian follicle development
    Herbert Y Lin; Fiscal Year: 2010
    ..We have also shown that RGMa and RGMc facilitate the use of BMP type II receptor ActIIA by BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII...
  22. Identification of the Bmp2 Chondrocyte Enhancer
    Steven Pregizer; Fiscal Year: 2012
    ..b>Bone Morphogenetic Protein 2 (Bmp2) is one such molecule...
  23. Suk Won Jin; Fiscal Year: 2016
    ..We have recently demonstrated that Bone Morphogenetic Protein 2 (BMP2) signaling functions as a context dependent pro-angiogenic cue in zebrafish, promoting ..
  24. Sarah L Dallas; Fiscal Year: 2014
    ..Fibronectin's effects on differentiation can be rescued by supplementation with BMP2, whereas its effects on ECM assembly and mineralization cannot, suggesting that fibronectin may regulate osteoblast ..
  25. Selvarangan Ponnazhagan; Fiscal Year: 2016
    ..Using this targeting approach, we recently demonstrated that MSC, genetically-engineered to produce BMP2, significantly improved bone density during first few months in a mouse model of osteoporosis...
  26. The Role of Osteoactivin in Osteoblast Development and Function
    Fayez F Safadi; Fiscal Year: 2013
    ..synthesized and secreted by osteoblasts, and acts either as an ECM-associated signaling molecule or downstream of BMP2 to regulate osteoblast differentiation and function...
  27. DYNAMICS OF ASSEMBLY OF BONE MATRIX PROTEINS
    SARAH DALLAS; Fiscal Year: 2009
    ..Fibronectin[unreadable]s effects on differentiation can be rescued by supplementation with BMP2, whereas its effects on ECM assembly and mineralization cannot, suggesting that fibronectin may regulate osteoblast ..
  28. Regulation of Osteoblast Differentiation by Delta FosB
    ROLAND E BARON; Fiscal Year: 2012
    ..fails to repress beta-catenin transactivation in response to Wnt3a or to induce the inhibitory Smad6 inresponse to BMP2. These are major breakthroughs in our understanding of the DFosB osteosclerotic phenotype: the increased BF when ..
  29. ANJA G NOHE; Fiscal Year: 2016
    ..Addition of CK2.3 to cells leads to the activation of BMP2 signaling pathways and mineralization. Injection of CK2...
  30. Transcriptional Regulation of Indian Hedgehog Expression in Chondrocytes
    Xiangli Yang; Fiscal Year: 2012
    ..the Hedgehog (Hh) pathway, which controls target genes in chondrogenesis such as PTHrP and osteogenesis such as BMP2, is essential for normal endochondral bone formation...
  31. Jennifer L Bain; Fiscal Year: 2014
    ..to bone grafts to increase loading and retention of osteoinductive molecules: collagen mimetic peptide (DGEA), BMP2 peptide, and rBMP2 protein will be synthesized with E7 domains and evaluated for loading and retention on three ..
  32. Role and Mechanism of BMP4 and BMP2 Action and Signaling in Bone
    STEPHEN EUBANK HARRIS; Fiscal Year: 2011
    Mutations in the human BMP4 and BMP2 genes have been associated with osteoporosis and these BMPs signal through a variety of BMP receptors...
  33. Heterotopic bone from stem cells in peripheral nerves released by neurogenic infl
    ALAN ROBERT DAVIS; Fiscal Year: 2013
    ..have led us to hypothesize that peripheral nerves possess progenitors/stem cells, which expand in response to BMP2 for contribution to the newly forming heterotopic bone...
  34. Inhibition of osteoblast function in bone erosion in rheumatoid arthritis
    Ellen M Gravallese; Fiscal Year: 2013
    ..Expression of BMP3, an inhibitor of pro-osteogenic BMP2 signaling, and of two Wnt signaling pathway inhibitors, Dickkopf1 (DKK1) and secreted Frizzled related-protein1 (..
  35. JULIANNE LEIGH HOLLOWAY; Fiscal Year: 2015
    ..Enhancing canonical Wnt signaling through the synergistic delivery of BMP2 and Rspo2 using an engineered synthetic HA-based hydrogel should allow for improved bone tissue repair...
  36. Xu Cao; Fiscal Year: 2014
    ..siRNA or chlorpromazine (an endocytosis inhibitor), suggests a mechanism by which PTH may increase the binding of BMP2 ligands to BMP receptors and integrate the signaling mechanisms spatially and temporally...
  37. Healing of Craniofacial Defects using Adipose-Derived Stem Cells
    Patricia A Zuk; Fiscal Year: 2013
    ..Current strategies for inducing stem cells to form bone in vivo involve combining them with growth factors like BMP2. However, the use of BMP2 may not be recommended in very young children with cleft defects due to the potential of ..
  38. Xiaohua Liu; Fiscal Year: 2014
    ..aims are proposed: 1) To develop injectable hierarchical NF-HMS scaffolding systems with controlled delivery of BMP2. 2) To test this scaffolding system as a promising injectable carrier for bone tissue regeneration...
  39. Mechanistic Role of NELL-1 in Premature Suture Closure
    Kang Ting; Fiscal Year: 2003
    ..IGF 1 & 2, PDGF, VEFG, and BMP2, on the other hand, have no effect on NELL-1 expression...
  40. Microsphere-mediated differentiation of embryonic stem cells
    Todd C McDevitt; Fiscal Year: 2013
    ..bodies (EBs), 2) determine the spatiotemporal effects of independently delivering morphogens, such as Wnt 3a and BMP2, within EB microenvironments, and 3) examine the effects of sequential delivery of different morphogens (Wnt3a and ..
  41. Genetic Studies of Mammalian Gametogenesis
    Guang Quan Zhao; Fiscal Year: 2004
    ..Our preliminary studies have shown that several murine genes encoding BMPs of the DPP class (BMP2 and BMP4) and the 60A class (BMP7, BMP8A, and BMP8B), BMP receptors (ALK3 and TALK), and the downstream signal ..
  42. TNF-ALPHA AND BMP2-WNT SIGNALING IN DIABETIC VASCULAR DISEASE
    Dwight A Towler; Fiscal Year: 2012
    ..Recent data have identified activated aortic BMP2-Msx2-Wnt signaling in diabetic MAC--all inhibited by infliximab...
  43. David A Bushinsky; Fiscal Year: 2016
    ..that suppression of Snail in GHS rats is due to either decreased signal(s) that up-regulate Snail (TGF2-1, BMP2) or enhanced signals that down-regulate Snail (miRs let-7 family). 3...
  44. Ivo Kalajzic; Fiscal Year: 2016
    ..repair that include fracture healing and induction of osteogenic potential using ectopic bone formation induced by BMP2, we will evaluate the progenitor ability of SMA expressing cells...
  45. Mechanistic Characterization and Genetic Analysis of Systemic Iron Homeostasis
    Xin Du; Fiscal Year: 2011
    ..overexpression under basal condition and upon stimulation with the potent upregulator of hepcidin expression, BMP2. A few genes were found to be differentially modulated by TMPRSS6 overexpression, providing possible links in the ..
  46. Christine E Larkins; Fiscal Year: 2014
    ..molecular control of puo morphogenesis through examination of changes in gene expression and cellular events in Bmp2 and Fgfr2 mutants...
  47. The Role of BMP2 in the Regenerative Effects of MSC in Fracture Repair
    TIMOTHY JOSEPH MYERS; Fiscal Year: 2013
    ..Bone morphogenic protein-2 (BMP2) is one of these secreted molecules that are crucial to the fracture repair process. Studies published in Dr...
  48. Lisa J Bain; Fiscal Year: 2014
    ..Specifically, we will use Wnt1, Wnt3, Wnt3a, Wnt5a, noggin, Bmp2, and Bmp4 to differentiate the embryonic stem cells and investigate whether arsenic abrogates sensory neuron and ..
  49. DEVELOPMENT AND REGENERATION OF SKIN APPENDAGES
    Cheng Ming Chuong; Fiscal Year: 2013
    ..The unexpected links of Bmp2 expression with subcutaneous adipocytes and the resetting of hair waves during pregnancy give implications in ..
  50. Scott J Hollister; Fiscal Year: 2014
    ..project is to investigate a novel completely bioresorbable integrated structural/delivery scaffold for controlled BMP2 delivery in cervical spine fusion...
  51. Bone Morphogenic Proteins as Novel Regulators of Beta Cell Growth
    JAKE ALDEN KUSHNER; Fiscal Year: 2012
    ..Importantly, an FDA approved BMP2 drug is already in routine clinical use to speed healing of bone fractures...
  52. BASIC FIBROBLAST GROWTH FACTOR EXPRESSION IN BONE CELLS
    Marja Hurley; Fiscal Year: 2003
    ..examine the expression of genes which support osteoblast differentiation which may be downstream of FGF-2 including BMP2 and TGFbeta...
  53. Hormone-Regulated Pathways Controlling Implantation and Fertility
    Milan K Bagchi; Fiscal Year: 2012
    ..in Implantation and Uterine Function, (3) Regulation of Stromal Differentiation and Implantation by the BMP2 Pathway, and (4) Endometriosis as a Clinical Model of Predecidual Dysfunction...
  54. MSX2-Wnt Signaling in Cardiovascular Calcification
    Dwight A Towler; Fiscal Year: 2013
    ..and Wnt7 /LRP6 interactions as important in vascular calcification and tissue fibrosis -- down-stream of TNF-, BMP2-, and Msx2- activated osteogenic mineralization...
  55. DSPP signaling in dentinogenesis
    Shuo Chen; Fiscal Year: 2013
    ..These domains play unique biological functions during dentinogenesis. Preliminary data showed that 1). BMP2 induced DSPP expression...
  56. Beta-Catenin Signaling and Pathogenesis of Osteoarthritis
    Di Chen; Fiscal Year: 2013
    ..in articular chondrocytes and its abnormal activation will lead to the development of an OA-like phenotype;and 2) Bmp2 and Mmp13 are key downstream target genes of [unreadable]-catenin signaling in articular chondrocytes and deletion ..
  57. Molecular Mechanisms Regulating Drosophila Ovarian Germline Stem Cells
    Ting Xie; Fiscal Year: 2010
    ..We have recently shown that Gbb/BMP5-8 and Dpp/BMP2-4 from the niche control GSC self- renewal by repressing expression of a differentiation-promoting gene bam...
  58. WILLIAM D MERRYMAN; Fiscal Year: 2016
    ..Notch1+/- leads to increased synthesis and/or signaling of both BMP2 and TGF-b1 in the AV leaflets of mice, which results in CAVD...
  59. Molecular mechanisms and epigenetic signatures that specify thymus fate
    Ellen R Richie; Fiscal Year: 2013
    ..Previous work from our labs and others have implicated BMP2/4 and FGF8/10 signals in establishing thymus fate, while SHH signaling is required for parathyroid fate...
  60. TGF B1'S ROLE IN PRIMARY AND REPARATIVE DENTINOGENESIS
    RENA D SOUZA; Fiscal Year: 2001
    ..The expression and functional relationship of genes like Bmp2 and Msx2 that may potentially interact with TGF-beta1 will be assessed in TGF-beta1(-/-) nude and Msx2(-/-) mice ..
  61. A ROLE FOR NOGGIN AND BMP2/4 IN HAIR GROWTH CONTROL
    Vladimir Botchkarev; Fiscal Year: 2003
    ..Bone morphogenic proteins 2/4 (BMP2/4), members of transforming growth factor- beta/BMP superfamily, and their specific antagonist noggin, which binds ..
  62. BMP Induced Regeneration of an Endochondral Growth Zone in Digit Regeneration
    Ling Yu; Fiscal Year: 2012
    ..skeletal regeneration can be induced from non-regenerating amputation injuries by treatment with either BMP7 or BMP2. This BMP-induced regeneration response provides a unique opportunity to study underlying molecular and cellular ..
  63. The Role of FoxC1 in BMP-Mediated Msx2 Induction
    Theodora Danciu; Fiscal Year: 2009
    ..Smads and FoxC1, to define the DMA target site preference for FoxC1 and to determine the role of phosphorylation in BMP2-induced FoxC1-dependent Msx2 transcriptional regulation...
  64. RETINOIC ACID REGULATED GENES AND EMBRYOS
    Melissa Rogers; Fiscal Year: 2003
    ..First, RA directly induces the Bmp2 gene. Second, cells exposed to RA or BMP2 or BMP4 alone or the combination of RA and a BMP behave differently...
  65. EXPRESSION OF ATTACHMENT PROTEINS DURING CEMENTOGENESIS
    Martha Somerman; Fiscal Year: 2006
    ..BSP and OCN, in vitro; 2) ameolgenin null mice lack transcripts for BSP; 3) follicle cells express transcripts for BMP2 and 3; and 4) BMP2 promotes follicle cell differentiation toward a cementoblast/osteoblast phenotype, while BMP3 ..