BLU

Summary

Gene Symbol: BLU
Description: zinc finger MYND-type containing 10
Alias: BLU, CILD22, FLU, zinc finger MYND domain-containing protein 10, protein BLu
Species: human

Top Publications

  1. ncbi The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium
    M I Lerman
    Laboratory of Immanobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    Cancer Res 60:6116-33. 2000
  2. ncbi Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers
    Angelo Agathanggelou
    Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, The Medical School, Edgbaston, Birmingham B15 2TT, UK
    Oncogene 22:1580-8. 2003
  3. ncbi Alterations of BLU, a candidate tumor suppressor gene on chromosome 3p21.3, in human nasopharyngeal carcinoma
    Xiao Qiong Liu
    Cancer Center, Sun Yat Sen University, Guangzhou, China
    Int J Cancer 106:60-5. 2003
  4. ncbi Frequent epigenetic inactivation of RASSF1A and BLU genes located within the critical 3p21.3 region in gliomas
    Luke Hesson
    Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, Birmingham B15 2TT, UK
    Oncogene 23:2408-19. 2004
  5. ncbi The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma
    Guo Hua Qiu
    Cancer Epigenetics Tumor Virology Laboratory, Division of Johns Hopkins in Singapore, Singapore
    Oncogene 23:4793-806. 2004
  6. ncbi Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Int J Cancer 114:219-23. 2005
  7. ncbi Allele loss and epigenetic inactivation of 3p21.3 in malignant liver tumors
    Iris Tischoff
    Institute of Pathology, University of Leipzig, Leipzig, Germany
    Int J Cancer 115:684-9. 2005
  8. ncbi Functional studies of the chromosome 3p21.3 candidate tumor suppressor gene BLU/ZMYND10 in nasopharyngeal carcinoma
    Wing Lung Yau
    Department of Biology and Center for Cancer Research, The Hong Kong University of Science and Technology, Hong Kong SAR, China
    Int J Cancer 119:2821-6. 2006
  9. ncbi [An outbreak of waterborne Cryptosporidiosis in Kanagawa, Japan]
    T Kuroki
    Department of Bacteriology and Pathology, Kanagawa Prefectural Public Health Laboratory
    Kansenshogaku Zasshi 70:132-40. 1996
  10. pmc Interferons in the management of neuroendocrine tumors and their possible mechanism of action
    K Oberg
    Department of Internal Medicine and Ludwig Institute for Cancer Research, University Hospital, Uppsala, Sweden
    Yale J Biol Med 65:519-29; discussion 531-6. 1992

Research Grants

  1. Mechanisms of non-neutralizing antibody-mediated protection from influenza virus
    DENISE KAMINSKI; Fiscal Year: 2009
  2. Developing a Paramyxovirus-based H5N1 Vaccine
    Biao He; Fiscal Year: 2012
  3. Development of Cross Protective H5 Hemagglutinin Antigens
    Susan C Bock; Fiscal Year: 2010
  4. Rational design of M2e-FP conserved epitope-based universal influenza A vaccines
    Lanying Du; Fiscal Year: 2012
  5. HA Surface Presented Yeast Flu Vaccine and Its Enhancement by CD154 Codisplay
    Kaiming Ye; Fiscal Year: 2012
  6. Kam W Leong; Fiscal Year: 2016
  7. Savita Pahwa; Fiscal Year: 2016
  8. Origin and Adaptation of Influenza-Specific Plasmablasts
    SARAH FAITH ANDREWS; Fiscal Year: 2013
  9. Allen G Harmsen; Fiscal Year: 2016
  10. THE FLU-FOBT PROGRAM: TRANSLATION OF AN EVIDENCE-BASED COLORECTAL CANCER SCREENI
    Michael B Potter; Fiscal Year: 2010

Detail Information

Publications222 found, 100 shown here

  1. ncbi The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium
    M I Lerman
    Laboratory of Immanobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    Cancer Res 60:6116-33. 2000
    ..or reduced mRNA levels in non-small cell lung cancer (CACNA2D2/alpha2delta-2, SEMA3B [formerly SEMA(V), BLU, and HYAL1] or small cell lung cancer (SEMA3B, BLU, and HYAL1) cell lines...
  2. ncbi Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers
    Angelo Agathanggelou
    Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, The Medical School, Edgbaston, Birmingham B15 2TT, UK
    Oncogene 22:1580-8. 2003
    Many distinct regions of 3p show frequent allelic losses in a wide range of tumour types. Previously, the BLU candidate tumour suppressor gene (TSG) encoded by a gene-rich critical deleted region in 3p21...
  3. ncbi Alterations of BLU, a candidate tumor suppressor gene on chromosome 3p21.3, in human nasopharyngeal carcinoma
    Xiao Qiong Liu
    Cancer Center, Sun Yat Sen University, Guangzhou, China
    Int J Cancer 106:60-5. 2003
    ..The BLU gene, located at 3p21...
  4. ncbi Frequent epigenetic inactivation of RASSF1A and BLU genes located within the critical 3p21.3 region in gliomas
    Luke Hesson
    Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, Birmingham B15 2TT, UK
    Oncogene 23:2408-19. 2004
    ..3 tumor suppressor genes. CACNA2D2 and SEMA3B were not frequently methylated, but the BLU gene located just centromeric to RASSF1 was frequently methylated in glioma cell lines (7/7) and in 80% (35/44) of ..
  5. ncbi The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma
    Guo Hua Qiu
    Cancer Epigenetics Tumor Virology Laboratory, Division of Johns Hopkins in Singapore, Singapore
    Oncogene 23:4793-806. 2004
    Loss of heterozygosity at 3p21 is common in various cancers including nasopharyngeal carcinoma (NPC). BLU is one of the candidate tumor suppressor genes (TSGs) in this region...
  6. ncbi Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Int J Cancer 114:219-23. 2005
    The putative tumor suppressors RASSF1A and BLU are mapped adjacent to one another on chromosome 3p21.3, a region frequently deleted in lung cancer...
  7. ncbi Allele loss and epigenetic inactivation of 3p21.3 in malignant liver tumors
    Iris Tischoff
    Institute of Pathology, University of Leipzig, Leipzig, Germany
    Int J Cancer 115:684-9. 2005
    Previously, the RASSF1A, BLU and SEMAPHORIN 3B (SEMA3B) candidate tumor suppressor genes on chromosome 3p21.3 were found to be inactivated and downregulated by genetic and epigenetic changes in lung cancer...
  8. ncbi Functional studies of the chromosome 3p21.3 candidate tumor suppressor gene BLU/ZMYND10 in nasopharyngeal carcinoma
    Wing Lung Yau
    Department of Biology and Center for Cancer Research, The Hong Kong University of Science and Technology, Hong Kong SAR, China
    Int J Cancer 119:2821-6. 2006
    ..3 region was critical for tumor suppression. BLU/ZMYND10 is one of the candidate tumor suppressor genes mapping in the 3p21...
  9. ncbi [An outbreak of waterborne Cryptosporidiosis in Kanagawa, Japan]
    T Kuroki
    Department of Bacteriology and Pathology, Kanagawa Prefectural Public Health Laboratory
    Kansenshogaku Zasshi 70:132-40. 1996
    ..surveys by a questionnaire revealed that 461 out of 736 persons investigated complained of cholera-like or flu-like illness. The clinical manifestations included mucous and/or watery diarrhea (96.7%), abdominal pain (61...
  10. pmc Interferons in the management of neuroendocrine tumors and their possible mechanism of action
    K Oberg
    Department of Internal Medicine and Ludwig Institute for Cancer Research, University Hospital, Uppsala, Sweden
    Yale J Biol Med 65:519-29; discussion 531-6. 1992
    ..The adverse reactions to alpha-interferon treatment are dose-dependent and include, mainly, flu-like symptoms, fatigue, and low-grade weight loss...
  11. ncbi [Initial results of a controlled study of small cell and squamous epithelial bronchial cancer: polychemotherapy and interferons]
    P Zabel
    Medizinische Klinik, Borstel
    Pneumologie 44:586-7. 1990
    ..Besides the common "flu-like" symptoms there was considerable myelosuppression in patients under additional interferon therapy...
  12. ncbi Botulinum-A toxin in the treatment of craniocervical muscle spasms: short- and long-term, local and systemic effects
    J J Dutton
    Duke University Eye Center, Durham NC 27710, USA
    Surv Ophthalmol 41:51-65. 1996
    ..These include pruritus, dysphagia, nausea, and a flu-like syndrome...
  13. ncbi A phase II study of mitomycin C, vindesine and cisplatin combined with alpha interferon in advanced non-small cell lung cancer
    R R Silva
    Oncology Unit, Ospedale ¿Profili, Fabriano (AN, Italy
    Tumori 82:68-71. 1996
    ..5 months (range, 1-32). WHO grade 3 toxicity was recorded in up to 8% of patients, flu-like syndrome was a common complaint; one toxic death occurred...
  14. ncbi [A case of an elderly patient with dementia and gait disturbance associated with influenza]
    A Nabeshima
    Department of General Medicine, Kyushu University
    Kansenshogaku Zasshi 71:944-8. 1997
    ..At admission, conversation and comprehension were not significantly impaired, and she was able to walk by herself. Flu symptoms such as high grade fever, chills, arthralgia, and cough appeared after a short stay at home...
  15. ncbi [Evaluation of immunochromatography method for rapid detection of influenza A and B viruses]
    C Kawakami
    Yokohama City Institute of Health
    Kansenshogaku Zasshi 75:792-9. 2001
    ..0 x 10(5) pfu/ml for the QuickVue Influenza test, 1.5 x 10(5) to 1.0 x 10(6) pfu/ml for the Directigen Flu A, and 7.5 x 10(5) to 5.0 x 10(6) pfu/ml for the FLU OIA...
  16. pmc Interaction of Candida albicans biofilms with antifungals: transcriptional response and binding of antifungals to beta-glucans
    Govindsamy Vediyappan
    Unité Biologie et Pathogénicité Fongiques, Institut Pasteur, Paris, France
    Antimicrob Agents Chemother 54:2096-111. 2010
    ..albicans biofilms grown under continuous flow were exposed for as long as 2 h to concentrations of fluconazole (FLU), amphotericin B (AMB), and caspofungin (CAS) that, while lethal for planktonic cells, were not lethal for biofilms...
  17. ncbi Alpha interferon as initial treatment of essential thrombocythemia. Analysis after two years of follow-up
    E M Pogliani
    Hematology Unit, Monza Hospital, Italy
    Tumori 81:245-8. 1995
    ..Four patients refused to continue therapy because of low tolerance (flu-like syndrome) at mean of 160 days from the beginning of therapy (range, 34-301)...
  18. ncbi China's efforts at avian influenza treatment and prevention
    Jp Li
    School of Pharmaceutical Sciences, Shandong University, Ji Nan, Shandong Province, China
    Biosci Trends 3:1-2. 2009
    ..info.gov.hk/info/flu/eng/global.htm" target="_blank" class="blue">http://www.info.gov.hk/info/flu/eng/global.htm</a>)...
  19. ncbi Recombinant interferon gamma treatment in non-small cell lung cancer. Antitumour effect and cardiotoxicity
    K Mattson
    Department of Pulmonary Medicine, Helsinki University Central Hospital, Finland
    Acta Oncol 30:607-10. 1991
    ..IFN-gamma treatment was discontinued due to toxicity in 7/15 of patients. Main toxicities were the 'flu'-like syndrome (in 15 patients) and cardiovascular events (in 13 patients)...
  20. ncbi Long-term success with the national health objective for influenza vaccination: an institution-wide model
    K L Nichol
    Section of General Internal Medicine, VA Medical Center, Minneapolis, MN 55417
    J Gen Intern Med 7:595-600. 1992
    ..educational strategies: 1) a hospital policy allowing nurses to vaccinate without a physician's order; 2) a walk-in flu shot clinic; 3) reminders on clinic progress notes; and 4) an educational mailing to all outpatients...
  21. ncbi [A clinical study of six cases of toxic shock-like syndrome by group A Streptococcus]
    T Ishida
    Department of Internal Medicine, Kurashiki Central Hospital
    Kansenshogaku Zasshi 69:873-7. 1995
    ..Every patient had from the onset flu-like symptoms or high fever and immediately developed some of the following clinical signs: hypotension, acute ..
  22. ncbi [Clinical evaluation of an immunochromatography test for rapid diagnosis of influenza]
    M Yamazaki
    Department of Pediatrics, Hadano Red Cross Hospital
    Kansenshogaku Zasshi 75:1047-53. 2001
    ..The sensitivity and specificity of the QuickVue Influenza Test were equivalent to those of Flu OIA (BioStar, Inc., Boulder, CO, USA), with the agreement of 84.2%...
  23. ncbi Alpha-2 interferon and 5-fluorouracil in advanced colorectal cancer
    A Fornasiero
    Divisione di Oncologia Medica, U.S.S.L. 21 Padova, Italy
    Tumori 76:385-8. 1990
    ..Side effects (fever, flu-like syndrome and leukopenia) required a dose reduction of 5-fluorouracil in 8 patients and interferon in 2 patients...
  24. doi Characterization of asymmetric fluorogenic phosphonates as probes for developing organophosphorus hydrolases with broader stereoselectivity
    G Amitai
    Department of Medicinal Chemistry, Israel Institute for Biological Research, Ness Ziona, Israel
    Chem Biol Interact 175:249-54. 2008
    ..new OPHs with broader stereoselectivity we have prepared a series of asymmetric fluorogenic organophosphonates (Flu-OPs)...
  25. ncbi Rapid and sensitive detection of respiratory virus infections for directed antiviral treatment using R-Mix cultures
    Kirsten St George
    Clinical Virology Laboratory, University of Pittsburgh Medical Center, A 912, Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Clin Virol 24:107-15. 2002
    ..We therefore investigated a new rapid culture system (R-Mix) that contains a mixture of two cell lines and detects respiratory viruses within 24 h...
  26. pmc Efficacies of high-dose fluconazole plus amphotericin B and high-dose fluconazole plus 5-fluorocytosine versus amphotericin B, fluconazole, and 5-fluorocytosine monotherapies in treatment of experimental endocarditis, endophthalmitis, and pyelonephritis d
    A Louie
    Divisions of Infectious Diseases, Albany Medical College, Albany, New York 12208, USA
    Antimicrob Agents Chemother 43:2831-40. 1999
    We compared the efficacies of fluconazole (Flu), amphotericin B (AmB), and 5-fluorocytosine (5FC) monotherapies with the combination of Flu plus 5FC and Flu plus AmB in a rabbit model of Candida albicans endocarditis, endophthalmitis, ..
  27. ncbi [Impact of influenza A virus infection as a cause of pediatric hospitalization and use of rapid antigen test of influenza A virus]
    K Mitamura
    Department of Pediatrics, Nippon Kokan Hospital
    Kansenshogaku Zasshi 72:883-9. 1998
    ..110 specimens of hospitalized children were examined by rapid antigen test of influenza A virus (Directigen Flu A, Becton Dickinson, USA)...
  28. ncbi Residue level, persistence, and storage performance of citrus fruit treated with fludioxonil
    Mario Schirra
    C N R Istituto di Scienze delle Produzioni Alimentari, Sezione di Sassari, via dei Mille, 07100 Sassari, Italy
    J Agric Food Chem 53:6718-24. 2005
    The potential of postharvest dip treatments with fludioxonil (FLU) (a synthetic analogue of the bacterial metabolite of pyrrolnitrin), in controlling postharvest decay caused by Penicillium digitatum and Penicillium italicum of citrus ..
  29. ncbi Antifungal susceptibilities of Cryptococcus neoformans cerebrospinal fluid isolates and clinical outcomes of cryptococcal meningitis in HIV-infected patients with/without fluconazole prophylaxis
    Weerawat Manosuthi
    Bamrasnaradura Institute, Ministry of Public Health, Nonthaburi, Thailand
    J Med Assoc Thai 89:795-802. 2006
    To compare the MICs of FLUconazole (FLU) and amphotericin B against isolates of Cryptococcus neoformans (C...
  30. ncbi [Optical immunoassay test for rapid detection of influenza A and B viruses: an evaluation]
    K Mitamura
    Department of Pediatrics, Nippon Kokan Hospital
    Kansenshogaku Zasshi 73:1069-73. 1999
    The optical immunoassay test (FLU OIA, BioStar, USA) for rapid detection of influenza A and B viral antigens was compared with viral isolation in cell culture...
  31. ncbi Differential serotonergic inhibition of in vitro striatal [3H]acetylcholine release in prenatally cocaine-exposed male and female rats
    Carlos A Bolanos
    Psychology Department, Northeastern University, Boston, MA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:1339-48. 2002
    ..The present study examines the effects of fluoxetine (FLU)-induced and exogenous serotonin (5-HT) on electrically evoked ACh release from striatal slices prepared from adult ..
  32. ncbi Detection of a new N-oxidized metabolite of flutamide, N-[4-nitro-3-(trifluoromethyl)phenyl]hydroxylamine, in human liver microsomes and urine of prostate cancer patients
    Rika Goda
    R and D Division, Pharmaceuticals Group, Nippon Kayaku Co, Ltd, 3 31 12 Shimo, Tokyo 115 8588, Japan
    Drug Metab Dispos 34:828-35. 2006
    ..2-Hydroxyflutamide (OH-flutamide) and 4-nitro-3-(trifluoromethyl)phenylamine (FLU-1) were the main products of flutamide metabolism in human liver microsomes...
  33. pmc Simultaneous detection and high-throughput identification of a panel of RNA viruses causing respiratory tract infections
    Haijing Li
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Microbiol 45:2105-9. 2007
    ..The NGEN respiratory virus analyte-specific assay (Nanogen, San Diego, CA) detects influenza A virus (Flu-A) and Flu-B, parainfluenza virus 1 (PIV-1), PIV-2, and PIV-3, and respiratory syncytial virus (RSV), while the ..
  34. ncbi [Clinical evaluation of rapid diagnostic kit detecting separately influenza A and B viruses]
    M Yamazaki
    Department of Pediatrics, Hatano Red Cross Hospital
    Kansenshogaku Zasshi 74:1032-7. 2000
    The Directigen Flu A + B kit, a rapid diagnostic device for influenza virus A and B was evaluated...
  35. ncbi Successful preemptive cidofovir treatment for CMV antigenemia after dose-reduced conditioning and allogeneic blood stem cell transplantation
    U Platzbecker
    Medical Clinic I, University Hospital Carl Gustav Carus, Dresden, Germany
    Transplantation 71:880-5. 2001
    ..Cidofovir (CDV) is a nucleotide analogue with proven in vitro effects against cytomegalovirus (CMV) and adenovirus and has been successfully used in the treatment of CMV retinitis in AIDS patients...
  36. ncbi [Evaluation of the rapid detection test for influenza A and B viruses using neuraminidase activity]
    K Mitamura
    Department of Pediatrics, Nippon Kokan Hospital
    Kansenshogaku Zasshi 74:12-6. 2000
    ..showed lower sensitivity than throat swabs at this test, different from EIA test kits such as Directigen FluA or FLU OIA. Overall, only 5 specimens were false positive by the ZstatFlu test...
  37. ncbi Stem cell transplantation using non-myeloablative conditioning regimen with fludarabine for hematological malignancies
    Kenji Tajika
    Department of Pathophysiological Management Medical Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 77:254-9. 2010
    ..Fludarabine (Flu), a novel anticancer agent with potent immunosuppressive activity, used as a conditioning regimen (reduced ..
  38. pmc Initial psychological responses to Influenza A, H1N1 ("Swine flu")
    Robin Goodwin
    Social Sciences, Brunel University, Uxbridge UK
    BMC Infect Dis 9:166. 2009
    The outbreak of the pandemic flu, Influenza A H1N1 (Swine Flu) in early 2009, provided a major challenge to health services around the world...
  39. ncbi Combined endocrine treatment of elderly postmenopausal patients with metastatic breast cancer. A randomized trial of tamoxifen vs. tamoxifen + aminoglutethimide and hydrocortisone and tamoxifen + fluoxymesterone in women above 65 years of age
    C Rose
    Department of Oncology, Odense University Hospital, Denmark
    Breast Cancer Res Treat 61:103-10. 2000
    ..therapy with tamoxifen (TAM), aminoglutethimide (AG), and hydrocortisone (H) or tamoxifen and fluoxymesterone (FLU) was evaluated against treatment with tamoxifen alone in 311 patients above 65 years of age with a first recurrence ..
  40. ncbi Asymmetric fluorogenic organophosphates for the development of active organophosphate hydrolases with reversed stereoselectivity
    Gabi Amitai
    Division of Medicinal Chemistry, Israel Institute for Biological Research, PO Box 19, Ness Ziona 74100, Israel
    Toxicology 233:187-98. 2007
    ..activity toward the more toxic isomer P(-) of nerve agents, we synthesized new asymmetric fluorogenic OPs (Flu-OPs)...
  41. ncbi [Evaluation of a rapid enzyme immunoassay membrane test for diagnosis of influenza A virus infection]
    H Shimizu
    Kawasaki City Institute of Public Health
    Kansenshogaku Zasshi 72:827-33. 1998
    A rapid enzyme immunoassay membrane test, Directigen Flu A (Becton Dickinson, USA), was evaluated by using virus isolates and clinical specimens. The reference laboratory diagnosis was based on the results of virus isolation...
  42. ncbi Headache characteristics in hospitalized patients with Lyme disease
    S N Scelsa
    Department of Neurology, Montefiore Medical Center, Bronx, NY 10467, USA
    Headache 35:125-30. 1995
    ..Patients with headaches more commonly had central nervous system involvement (54% vs 19%, P < .05) and flu-like illness (58% vs 19%, P < .0005)...
  43. ncbi Advanced prostatic cancer: clinical and hormonal response to flutamide in patients pretreated with LHRH analogue and cyproterone acetate
    F Di Silverio
    Institute of Urology, University of Rome La Sapienza, Italy
    Eur Urol 18:10-5. 1990
    ..combined with cyproterone acetate (CPA), substitution of this antiandrogen with another compound such as flutamide (FLU) might lead to further subjective and objective improvement...
  44. ncbi Effect of tianeptine and fluoxetine on the levels of Met-enkephalin and mRNA encoding proenkephalin in the rat
    M Dziedzicka-Wasylewska
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow
    J Physiol Pharmacol 53:117-25. 2002
    ..e. tianpetine (TIA, serotonin reuptake enhancer) and fluoxetine (FLU, serotonin reuptake inhibitor) on the levels of Met-Enkephalin, (Met-Enk, a member ofopioid peptide family, which ..
  45. doi Piperonyl butoxide enhances the bioconcentration and photoinduced toxicity of fluoranthene and benzo[a]pyrene to larvae of the grass shrimp (Palaemonetes pugio)
    John E Weinstein
    Department of Biology, The Citadel, Military College of South Carolina, Charleston, SC 29409, United States
    Aquat Toxicol 87:28-36. 2008
    ..influence of PBO on the bioconcentration and photoinduced toxicity of two common PAH contaminants, fluoranthene (FLU) and benzo[a]pyrene (BaP), on the larvae of the grass shrimp (Palaemonetes pugio)...
  46. ncbi The effect of a self-care minimal intervention for colds and flu on the use of medical services
    A Stergachis
    Center for Health Studies, University of Washington, Seattle 98195
    J Gen Intern Med 5:23-8. 1990
    ..URI drug prescriptions during the intervention period for all 20,127 patients showed no significant difference. CONCLUSIONS: A simple mailed self-care pamphlet has little effect on medical care utilization for URI care...
  47. ncbi Atypical androgen receptor in the human melanoma cell line IIB-MEL-J
    V Morvillo
    , Buenos Aires, Argentina
    Pigment Cell Res 8:135-41. 1995
    ..since not only androgen (testosterone, dihydrotestosterone [DHT], R1881) and antiandrogen (hydroxy-flutamide [OH-FLU]) competed for [3H]-R1881 binding, but also estradiol, progesterone, and cortisol at 500-fold excess concentration...
  48. ncbi [Costs of influenza therapy]
    M Kaji
    Kurume University Medical Center, Department of Neurology
    Kansenshogaku Zasshi 75:460-3. 2001
    ..After we confirmed the diagnosis of influenza by rapid diagnosis system (Directigen Flu A) or hemagglutinin inhibition test, neutralization test, comparison of costs was done between influenza patients (..
  49. ncbi Effect of fluvastatin on endothelium-dependent brachial artery vasodilation in patients after renal transplantation
    M Hausberg
    Department of Internal Medicine D, University of Munster, Munster, Germany
    Kidney Int 59:1473-9. 2001
    ..The aim of this double-blind, randomized trial was to evaluate the effects of fluvastatin (FLU) on brachial artery flow-mediated vasodilation (FMD) and DC in hypercholesterolemic NTX.
  50. ncbi Comparison of combinations of drugs for treatment of obesity: body weight and echocardiographic status
    L D Whigham
    Department of Medicine, University of Wisconsin, Madison, WI, USA
    Int J Obes (Lond) 31:850-7. 2007
    ..Fenfluramine is no longer available because it was associated with cardiac valve lesions. Phentermine-fluoxetine (phen-flu) has been proposed as an alternative for phen-fen.
  51. ncbi [Short communication: In vitro activity of amphotericin B with fluconazole or voriconazole combinations against Candida albicans isolates]
    Yasemin Oz
    Eskişehir Osmangazi Üniversitesi Tıp Fakültesi, Mikrobiyoloji Anabilim Dali, Eskisehir
    Mikrobiyol Bul 42:149-55. 2008
    ..were included to the study and the minimum inhibitory concentrations (MICs) of amphotericin B (AMB), fluconazole (FLU) and voriconazole (VOR) were determined by broth microdilution method and E-test...
  52. pmc Public perceptions, anxiety, and behaviour change in relation to the swine flu outbreak: cross sectional telephone survey
    G James Rubin
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, Weston Education Centre, London SE5 9RJ
    BMJ 339:b2651. 2009
    To assess whether perceptions of the swine flu outbreak predicted changes in behaviour among members of the public in England, Scotland, and Wales.
  53. ncbi [Use of a rapid detection assay for influenza virus, on nasal aspirate specimens]
    M Yamazaki
    Department of Pediatrics, Isehara Kyodo Hospital
    Kansenshogaku Zasshi 73:1064-8. 1999
    We investigated the usefulness of a rapid antigen detection kit using optical immunoassay for influenza virus (FLU OIA, BioStar, USA). Nasal aspirates were taken from 92 influenza suspected outpatients between March to April of 1999...
  54. ncbi Ability of regional hospitals to meet projected avian flu pandemic surge capacity requirements
    Raymond P Ten Eyck
    Center for Global Health Systems, Management, and Policy, Department of Community Medicine, Wright State University Boonshoft School of Medicine, Kettering, Ohio 45420, USA
    Prehosp Disaster Med 23:103-12. 2008
    ..Renewed concerns for infectious disease threats, particularly from a potential avian flu pandemic perspective, have emphasized the need to be prepared for a prolonged surge that could last six to eight ..
  55. doi A double-blind crossover study comparing the safety and efficacy of three weeks of Flu/Sal 250/50 bid plus albuterol 180 ug prn q4 hours to Flu/Sal 250/50 bid plus albuterol/Ipratropium bromide 2 puffs prn q4 hours in patients with chronic obstructive pul
    Ron Balkissoon
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    COPD 5:221-7. 2008
    ..Double-blind randomized crossover trial with COPD subjects receiving Fluticasone/ Salmeterol 500 microg/50 microg (Flu/Sal) 1 puff twice daily and 2 puffs of Albuterol Sulfate (90 microg micrograms per inhalation) or 2 puffs of ..
  56. pmc Comparison of in vitro bioactivation of flutamide and its cyano analogue: evidence for reductive activation by human NADPH:cytochrome P450 reductase
    Bo Wen
    Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California 94304, USA
    Chem Res Toxicol 21:2393-406. 2008
    Flutamide (FLU), a nonsteroidal antiandrogen drug widely used in the treatment of prostate cancer, has been associated with idiosyncratic hepatotoxicity in patients...
  57. doi Supramolecular solvents in solid sample microextractions: application to the determination of residues of oxolinic acid and flumequine in fish and shellfish
    Esther María Costi
    Department of Analytical Chemistry, Faculty of Sciences, University of Cordoba, Edificio Anexo Marie Curie, Campus de Rabanales, 14071 Cordoba, Spain
    J Chromatogr A 1217:1447-54. 2010
    ..The approach was evaluated by extracting flumequine (FLU) and oxolinic acid (OXO), two widely used veterinary medicines, from fish and shellfish muscle using a ..
  58. ncbi Prevention of flu episodes with colostrum and Bifivir compared with vaccination: an epidemiological, registry study
    G Belcaro
    Department of Biomedical Sciences, Irvine3 Circulation Vascular Labs and San Valentino Vascular Screening Project, G D Annunzio University, Chieti, Pescara, Italy
    Panminerva Med 52:269-75. 2010
    ..the efficacy of colostrum (ARD Colostrum) in association with the immunomodulator Bifivir in the prevention of flu episodes compared with anti-flu vaccination...
  59. ncbi Randomised active programs on healthcare workers' flu vaccination in geriatric health care settings in France: the VESTA study
    M Rothan-Tondeur
    ORIG French Geriatric Infection Risk Institute, Charles Foix Hospital, AP HP Publicly owned hospitals of Paris, Ivry sur Seine, France
    J Nutr Health Aging 15:126-32. 2011
    ..The health care workers (HCW) flu vaccination is known to get herd immunity and decrease the impact of influenza in elderly population living in ..
  60. ncbi [Sensitivity and specificity of rapid diagnosis kit detecting separately influenza A and B viruses]
    H Shimizu
    Kawasaki City Institute of Public Health
    Kansenshogaku Zasshi 74:1038-43. 2000
    Sensitivity and specificity of the Directigen Flu A + B kit, a rapid test for influenza virus A and B, were evaluated. This test detects influenza A and B viruses separately by EIA...
  61. pmc Flurbiprofen release from Eudragit RS and RL aqueous nanosuspensions: a kinetic study by DSC and dialysis experiments
    Francesco Castelli
    Dipartimento di Scienze Chimiche, Universita di Catania, Viale Andrea Doria, 6, Citta Universitaria, I 95125 Catania, Italy
    AAPS PharmSciTech 3:E9. 2002
    The present work investigated the release of Flurbiprofen (FLU) from Eudragit RS100 (RS) and Eudragit RL100 (RL) nanosuspensions to a biological model membrane consisting of Dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles (..
  62. ncbi Combined low-dose pioglitazone, flutamide, and metformin for women with androgen excess
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 92:1710-4. 2007
    ..for hyperinsulinemic hyperandrogenism in nonobese women is combined androgen receptor blockade (with flutamide; Flu), insulin sensitization (with metformin; Met) plus an estroprogestagen contraceptive...
  63. ncbi Alleviating flu-like symptoms with dose titration and analgesics in MS patients on intramuscular interferon beta-1a therapy: a pilot study
    David W Brandes
    Northridge MS Center, Northridge, CA 91325, USA
    Curr Med Res Opin 23:1667-72. 2007
    To determine the effectiveness of dose titration and choice of analgesic in reducing flu-like side effects of intramuscular interferon beta-1a (i.m. IFNbeta-1a).
  64. doi Mate calling behavior of male South African clawed frogs (Xenopus laevis) is suppressed by the antiandrogenic endocrine disrupting compound flutamide
    Thomas Behrends
    Institute of Biology, Humboldt University Berlin, Berlin, Germany
    Gen Comp Endocrinol 168:269-74. 2010
    ..pollutants have been identified as antiandrogenic endocrine disrupting chemicals (EDC), with flutamide (FLU) being a model compound for this type of action...
  65. doi Characterization of soldat8, a suppressor of singlet oxygen-induced cell death in Arabidopsis seedlings
    Nuria S Coll
    Institute of Plant Sciences, Plant Genetics, Swiss Federal Institute of Technology ETH, Zurich CH 8092, Switzerland
    Plant Cell Physiol 50:707-18. 2009
    The flu mutant of Arabidopsis thaliana overaccumulates in the dark the immediate precursor of chlorophyllide, protochlorophyllide (Pchlide), a potent photosensitizer, that upon illumination generates singlet oxygen ((1)O2)...
  66. doi Effect of oxytocin and flunixin meglumine on uterine response to insemination in mares
    A M Risco
    Service of Research and Technological Development, Junta de Extremadura, Estate La Orden, Guadajira Ba, Spain
    Theriogenology 72:1195-201. 2009
    ..The influence of oxytocin (OT; an ecbolic agent) and flunixin meglumine (FLU; a prostaglandin inhibitor serving as a model for mares with decreased uterine contractility) on uterine response ..
  67. ncbi [Effects of allogeneic hematopoietic stem cell transplantation on 60 patients with myelodysplastic syndrome]
    Yue Lu
    Department of Hematology, Beijing Daopei Hospital, Beijing 100049, China
    Zhonghua Nei Ke Za Zhi 49:200-3. 2010
    ..To evaluate the clinical outcome of all-ogeneic hematopoietic stem cell transplantation (all-HSCT) for myelodysplastic syndrome (MDS)...
  68. pmc Prostate cancer treated by anti-androgens: is sexual function preserved? EORTC Genitourinary Group. European Organization for Research and Treatment of Cancer
    F H Schroder
    Department of Urology, Erasmus University and Academic Hospital, Rotterdam, The Netherlands
    Br J Cancer 82:283-90. 2000
    ..untreated metastatic prostate cancer with favourable prognostic factors who were treated by either flutamide (FLU) or cyproterone acetate (CPA) monotherapy...
  69. ncbi Mechanism-based inhibition of CYP activities in rat liver by fluoxetine and structurally similar alkylamines
    M Murray
    Department of Physiology and Pharmacology, University of New South Wales, Australia
    Xenobiotica 33:973-87. 2003
    ..2. The selective serotonin-reuptake inhibitor fluoxetine (FLU) emerged as a potent and preferential inhibitor of CYP2C11 in rat liver microsomes...
  70. ncbi Antiviral activity of hop constituents against a series of DNA and RNA viruses
    Victor E Buckwold
    Infectious Disease Research Department, Southern Research Institute, 431 Aviation Way, Frederick, MD 21701, USA
    Antiviral Res 61:57-62. 2004
    ..BVDV) as a surrogate model of hepatitis C virus (HCV), human immunodeficiency virus (HIV), influenza A virus (FLU-A), influenza B virus (FLU-B), rhinovirus (Rhino), respiratory syncytial virus (RSV), yellow fever virus (YFV), ..
  71. ncbi Olanzapine versus flupenthixol in the treatment of inpatients with schizophrenia: a randomized double-blind trial
    W F Gattaz
    Department and Institute of Psychiatry, Laboratory of Neuroscience LIM 27, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos s n, PO Box 3671, 05403 010 Sao Paulo, Brazil
    Pharmacopsychiatry 37:279-85. 2004
    ..This exploratory double-blind 4-week study was designed to compare the efficacy and the safety of olanzapine (OLA) and flupenthixol (FLU) which have recently been considered as a "partially atypical" antipsychotics.
  72. doi A mutation in the Arabidopsis mTERF-related plastid protein SOLDAT10 activates retrograde signaling and suppresses (1)O(2)-induced cell death
    Rasa Meskauskiene
    Institute of Plant Sciences, Plant Genetics, ETH Zurich, CH 8092 Zurich, Switzerland
    Plant J 60:399-410. 2009
    The conditional flu mutant of Arabidopsis thaliana generates singlet oxygen ((1)O(2)) in plastids during a dark-to-light shift. Seedlings of flu bleach and die, whereas mature plants stop growing and develop macroscopic necrotic lesions...
  73. pmc Pharmacokinetic targeting of intravenous busulfan reduces conditioning regimen related toxicity following allogeneic hematopoietic cell transplantation for acute myelogenous leukemia
    Joseph Pidala
    Department of Blood and Marrow Transplantation, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
    J Hematol Oncol 3:36. 2010
    ..targeted IV busulfan (AUC < 6000 μM/L*min per day × 4 days) and fludarabine (40 mg/m2 × 4 days) - (t-IV Bu/Flu)...
  74. ncbi Residue levels and storage responses of nectarines, apricots, and peaches after dip treatments with fludioxonil fungicide mixtures
    Mario Schirra
    CNR Istituto di Scienze delle Produzioni Alimentari, via dei Mille, 07100 Sassari, Italy
    J Agric Food Chem 55:825-31. 2007
    ..persica (L.) Batsch.] were subjected to a 2 min dip treatment with warm water at 48 degrees C or with fludioxonil (FLU) at 100 mg L-1 and 20 degrees C or at 25 mg L-1 FLU and 48 degrees C and then stored at 5 degrees C and 90-95% ..
  75. ncbi Efficacy and tolerability in migraine prophylaxis of flunarizine in reduced doses: a comparison with propranolol 160 mg daily
    H C Diener
    Department of Neurology, University Essen, Germany
    Cephalalgia 22:209-21. 2002
    ..d.=FLU 10 mg and 5 mg o.d.=FLU 5 mg) in the prophylaxis of migraine, in comparison with slow-release propranolol (160 mg o...
  76. ncbi [Utilization and effectiveness of the flu vaccination in the prevention of the hospitalization induced by cardiorespiratory decompensation in high-risk patients in Cáceres]
    J F Sanchez Munoz-Torrero
    Complejo Hospitalario de Cáceres Hospital Nuestra Señora de la Montaña Cáceres Spain
    Rev Clin Esp 203:363-7. 2003
    Despite the recommendations to vaccinate annually against the flu to all the elderly and people with various chronic diseases, these recommendations are not comon to fulfill...
  77. ncbi [Mexican flu: risk perception in the general public, precautionary measures and trust in information provided by the government]
    Marloes Bults
    GGD Rotterdam Rijnmond, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 154:A1686. 2010
    ....
  78. ncbi Influenza surveillance during winter 1997-1998 in Israel
    T Peled
    Israel Center for Disease Control, Gertner Institute for Health Policy Research, Tel Hashomer, Israel
    Isr Med Assoc J 3:911-4. 2001
    ..Each winter influenza activity is a major cause of morbidity and mortality both in Israel and worldwide...
  79. ncbi Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu
    R Eccles
    Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    J Clin Pharm Ther 31:309-19. 2006
    Common cold and flu are the most common human illnesses, and over-the-counter (OTC) analgesics are widely used to treat the pain and fever symptoms...
  80. ncbi [Influenza and influenza-like illnesses in Slaskie voivodship in 2000-2005]
    Marek Ludwik Grabowski
    Główny Inspektorat Sanitarny
    Pol Merkur Lekarski 21:223-6. 2006
    ..epidemiological and virological surveillance of influenza and influenza-like illnesses, as well as the increase in flu vaccinations in each voivodship, is of significant importance, not only on account of seasonal morbidity, but also ..
  81. pmc Offering annual fecal occult blood tests at annual flu shot clinics increases colorectal cancer screening rates
    Michael B Potter
    Department of Family and Community Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Ann Fam Med 7:17-23. 2009
    We wanted to determine whether providing home fecal occult blood test (FOBT) kits to eligible patients during influenza inoculation (flu shot) clinics can contribute to higher colorectal cancer screening (CRCS) rates.
  82. doi Degradation of oxolinic acid and flumequine in aquaculture pond waters and sediments
    Hong Thih Lai
    Department of Aquatic Biosciences, National Chiayi University, 300 University Rd, Chiayi 60004, Taiwan, ROC
    Chemosphere 75:462-8. 2009
    Oxolinic acid (OA) and flumequine (FLU) are two of the quinolone antibiotics (QAs) that are widely used in aquaculture...
  83. ncbi [Spanish flu related data]
    Tadao Shimao
    Japan Anti Tuberculosis Association, Tokyo, Japan
    Kekkaku 84:685-9. 2009
    Swine flu epidemic is a current topic, and data relating to Spanish flu pandemic from 1918 to 1920 were presented for your information...
  84. ncbi Hepatotoxicity and consequently increased cell proliferation are associated with flumequine hepatocarcinogenesis in mice
    M Yoshida
    Department of Pathology, Sasaki Institute, Tokyo, Japan
    Cancer Lett 141:99-107. 1999
    It has been reported that flumequine (FLU) induces hepatic tumors in mice when given orally for 18 months. We investigated possible underlying mechanisms using a two-stage mouse hepatocarcinogenesis model...
  85. ncbi Recombination in the hemagglutinin gene of the 1918 "Spanish flu"
    M J Gibbs
    Division of Botany and Zoology, Faculty of Science, Australian National University, Canberra, ACT 2601, Australia
    Science 293:1842-5. 2001
    ..Phylogenetic analyses showed that this recombination, which probably changed the virulence of the virus, occurred at the start of, or immediately before, the pandemic and thus may have triggered it...
  86. ncbi Cytometric approach for a rapid evaluation of susceptibility of Candida strains to antifungals
    C Pina-Vaz
    Department of Microbiology, School of Medicine, University of Porto, Alameda Prof Hernani Monteiro, 4200 Porto, Portugal
    Clin Microbiol Infect 7:609-18. 2001
    To achieve a fast and reliable determination of the susceptibility of Candida strains to amphotericin B (Am B), fluconazole (Flu) and 5-fluorocytosine (5-FC), using cytometric methods as an alternative to the classical dilution method.
  87. ncbi Toxicity of a 24-hour infusion of gemcitabine in biliary tract and pancreatic cancer: a pilot study
    Florian Eckel
    Department of Internal Medicine II, Technical University of Munich, Klinikum rechts der Isar, Ismaningerstr 22, 81675 Munich, Germany
    Cancer Invest 20:180-5. 2002
    ..Other toxicities were oral mucositis, fever, flu-like symptoms, and asthenia. Maximum tolerated dose (MTD), especially in pretreated patients, was 100 mg/m2.
  88. ncbi Acute interferon beta-1b administration alters hypothalamic-pituitary-adrenal axis activity, plasma cytokines and leukocyte distribution in healthy subjects
    M U Goebel
    Department of Medical Psychology, Medical Faculty, University of Essen, Hufelandstr 55, 45122, Essen, Germany
    Psychoneuroendocrinology 27:881-92. 2002
    ..While typical adverse events of IFN beta-1b treatment such as flu-like symptoms or fatigue are well studied, little is known about the acute changes in the immune and neuroendocrine ..
  89. ncbi Disposition of sodium salicylate, flunixin and meloxicam after intravenous administration in broiler chickens
    K Baert
    Department of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    J Vet Pharmacol Ther 25:449-53. 2002
    Three nonsteroidal anti-inflammatory drugs (NSAIDs) [sodium salicylate, flunixin (FLU) and meloxicam (MEL)] were administered intravenously to broiler chickens...
  90. ncbi Imidazenil: an antagonist of the sedative but not the anticonvulsant action of diazepam
    James Auta
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor St, Chicago, IL 60612, USA
    Neuropharmacology 49:425-9. 2005
    Flumazenil (FLU), a specific benzodiazepine (BZ) receptor antagonist has been used in the treatment of acute BZ intoxication or the alleviation of BZ-induced withdrawal syndrome on the basis of its weak partial agonist action at GABA(A) ..
  91. ncbi Lyell's syndrome
    Adone Baroni
    Department of Dermatology, Second University of Naples, Naples, Italy
    Skinmed 4:221-5. 2005
    ..Preceded by fever, general malaise, and other flu-like symptoms, bullous and erosive lesions involve oral, ocular, and genital mucosae; and vast areas of the skin ..
  92. doi Pandemic flu: are we properly prepared?
    C J Bunting
    National Public Health Services for Wales, Wales, UK
    Public Health 122:591-6. 2008
    This paper presents the proceedings of the 2006 conference 'Pandemic flu: Are we properly prepared?', held in London...
  93. doi An influenza A H1N1 virus revival - pandemic H1N1/09 virus
    M Michaelis
    Institute for Medical Virology, Johann Wolfgang Goethe University Clinic, Frankfurt am Main, Germany
    Infection 37:381-9. 2009
    ..designations include swine influenza, novel influenza, swine-origin influenza A [H1N1] virus [S-OIV], Mexican flu, North American Flu) was identified in Mexico...
  94. doi Newly identified human rhinoviruses: molecular methods heat up the cold viruses
    Katherine E Arden
    Qpid Laboratory, Sir Albert Sakzewski Virus Research Centre, Queensland Children s Medical Research Institute, Royal Children s Hospital, Queensland, Australia
    Rev Med Virol 20:156-76. 2010
    Human rhinovirus (HRV) infections cause at least 70% of virus-related wheezing exacerbations and cold and flu-like illnesses. They are associated with otitis media, sinusitis and pneumonia...
  95. pmc Structural and functional analysis of NS1 and NS2 proteins of H1N1 subtype
    Parveen Salahuddin
    Distributed Information Sub Centre, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India
    Genomics Proteomics Bioinformatics 8:190-9. 2010
    Influenza A virus (H1N1), a genetic reassortment of endemic strains of human, avian and swine flu, has crossed species barrier to human and apparently acquired the capability of human to human transmission...
  96. doi A social-cognitive model of pandemic influenza H1N1 risk perception and recommended behaviors in Italy
    Gabriele Prati
    Department of Education, University of Bologna, Bologna, Italy
    Risk Anal 31:645-56. 2011
    The outbreak of the pandemic influenza H1N1 2009 (swine flu) between March and April 2009 challenged the health services around the world...
  97. ncbi [Seasonal and pandemic A (H1N1) 2009 influenza vaccination coverage among health-care workers in a French university hospital]
    Cécile Boyeau
    Service des Admissions et Urgences, CHU Angers, 4, rue Larrey, 49933 Angers cedex 09
    Sante Publique 23:19-29. 2011
    ..were "to protect the patient" and "to avoid getting sick"; arguments against vaccination were "I never get the flu" or "getting vaccinated is inconvenient and takes too long"...
  98. ncbi "Google flu trends" and emergency department triage data predicted the 2009 pandemic H1N1 waves in Manitoba
    Mohammad Tufail Malik
    Department of Mathematics, University of Manitoba, Winnipeg, MB
    Can J Public Health 102:294-7. 2011
    We assessed the performance of syndromic indicators based on Google Flu Trends (GFT) and emergency department (ED) data for the early detection and monitoring of the 2009 H1N1 pandemic waves in Manitoba.
  99. pmc A simple stochastic model with environmental transmission explains multi-year periodicity in outbreaks of avian flu
    Rong Hua Wang
    Department of Mathematics, North University of China, Taiyuan, Shan Xi, People s Republic of China
    PLoS ONE 7:e28873. 2012
    ..transmission provides a simple, plausible explanation for the phenomenon of multi-year periodic outbreaks of avian flu. Our theory predicts complex fluctuations with a dominant period of 2 to 8 years which essentially depends on the ..
  100. ncbi The effects of fever on hormone ghrelins, immunoglobulins, and heat shock protein 70 expression after swine flu vaccinations
    Suleyman Aydin
    Department of Medical Biochemistry and Clinical Biochemistry Firat Hormones Research Group, Medical School, Firat University, 23119 Elazig, Turkey
    Endocrine 42:352-8. 2012
    ..in immunoglobulins, HSP70, ghrelin levels in blood samples were collected from volunteers vaccinated against swine flu before the vaccinations and on days 3, and 15, and 1 and 2 months after the vaccination in the presence or absence ..
  101. doi A natural isolate producing shikimic acid: isolation, identification, and culture condition optimization
    Garima Rawat
    Department of Microbiology, University of Delhi South Campus, New Delhi, 110021, India
    Appl Biochem Biotechnol 169:2290-302. 2013
    ..wide use in pharmaceuticals due to its application in the synthesis of drug Tamiflu used in the treatment of Swine flu. The high cost and limited availability of shikimic acid isolated from plants has impeded the use of this valuable ..

Research Grants79

  1. Mechanisms of non-neutralizing antibody-mediated protection from influenza virus
    DENISE KAMINSKI; Fiscal Year: 2009
    ..could then be used to enhance cross-protection of human vaccines that could: 1) lessen the impact of seasonal flu, 2) prepare for unexpected strains and potentially pandemic outbreaks, and 3) provide long-term protection that ..
  2. Developing a Paramyxovirus-based H5N1 Vaccine
    Biao He; Fiscal Year: 2012
    ..outbreaks of pandemic influenza have caused significant mortality over the past century, most notably the Spanish flu of 1918, and have caused over 50 million deaths world wide...
  3. Development of Cross Protective H5 Hemagglutinin Antigens
    Susan C Bock; Fiscal Year: 2010
    ..There is concern that H5N1 bird flu viruses may in the future evolve to forms that are easily transmitted to, and among, people...
  4. Rational design of M2e-FP conserved epitope-based universal influenza A vaccines
    Lanying Du; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The current H1N1 influenza pandemic (commonly known as the "swine flu") and the potential outbreak of H5N1 influenza in the future pose serious threats to public health worldwide...
  5. HA Surface Presented Yeast Flu Vaccine and Its Enhancement by CD154 Codisplay
    Kaiming Ye; Fiscal Year: 2012
    ..Thus, this technology has the potential to impact broadly on our ability to treat and prevent virus-related diseases, stating with innumerable potential society benefits and large commercial potential. ..
  6. Kam W Leong; Fiscal Year: 2016
    ..The ineffectiveness of current flu vaccines in the elderly has been associated with immunosenescence, which is a gradual age-associated deterioration ..
  7. Savita Pahwa; Fiscal Year: 2016
    ..To investigate the nature and mechanism of the effect of immune activation on Ab responses to seasonal flu vaccination;2...
  8. Origin and Adaptation of Influenza-Specific Plasmablasts
    SARAH FAITH ANDREWS; Fiscal Year: 2013
    ..cells generated in response to the monomeric 2009 H1N1 vaccine following immunization with the annual trivalent flu vaccine...
  9. Allen G Harmsen; Fiscal Year: 2016
    ..The goal of this proposal is to integrate these two antigens (csHA and NP) with a highly engineer-able nano- platform to elicit protective immune responses in an effort aimed at the development of a universal influenza vaccine. ..
  10. THE FLU-FOBT PROGRAM: TRANSLATION OF AN EVIDENCE-BASED COLORECTAL CANCER SCREENI
    Michael B Potter; Fiscal Year: 2010
    ..Specific Aims: We propose to (1) adapt the "FLU-FOBT Program" for primary care clinics that provide influenza vaccines but do not run dedicated annual influenza ..
  11. Melinda A Beck; Fiscal Year: 2016
    ..This suggests that, similar to an aging population, an obese population may not respond adequately to flu vaccination...
  12. Effects of individual behavioral responses on benefits of influenza vaccination
    Byung Kwang Yoo; Fiscal Year: 2011
    ..negative individual incentives incurred by the observations of (i) a lower epidemic level or (ii) a high population flu vaccination coverage level;2) To conduct empirical analyses among Medicare elderly (a) to examine the determinants ..
  13. Srikanth Kadiyala; Fiscal Year: 2014
    ..The 2004-2005 flu season saw a substantial reduction in influenza vaccination rates due to a shortage in the supply of the influenza ..
  14. Optional Influenza Vaccine And Population Adherence
    Alison Galvani; Fiscal Year: 2009
    ..We will develop strategies for flu vaccination, taking into account how people choose whether to be vaccinated, the effect of their choices on others ..
  15. The Impact of Flu and Flu Vaccine on NH Resident Morbitidity
    Vincent Mor; Fiscal Year: 2011
    ....
  16. Rational Design of Live Attenuated Influenza A Vaccine Candidates
    Eckard Wimmer; Fiscal Year: 2013
    ..CA07 was the strain responsible for the 2009 H1N1 ("swine flu") pandemic...
  17. Development of live attenuated influenza virus vaccine
    Debi P Nayak; Fiscal Year: 2010
    ..Vaccines are in short supply essentially every year. Furthermore, there is a bird flu or avian flu virus posing a global pandemic threat against which there is no effective vaccine and massive amount ..
  18. Development of Influenza Virus-Like Particle (VLP) Vaccines
    Innocent N Mbawuike; Fiscal Year: 2011
    ..This SBIR Phase II will accelerate the creation of vital prophylactic vaccines (e.g. H5, H7 avian flu and 1918) and will also validate a faster, more flexible, cell-based technology for epidemic influenza vaccine ..
  19. Novel H1N1 influenza protection via cross-reactive immunity
    ANNE SEARLS DEGROOT; Fiscal Year: 2012
    ..and protective efficacy against novel H1N1 in the HLA transgenic mouse model when used to prime with/without flu vaccine, in collaboration with Dr. Richard Webby...
  20. DNA Vaccine for Seasonal &Pandemic Influenza
    Deborah H Fuller; Fiscal Year: 2011
    ..of this proposal is to increase PMED DNA vaccine immunogenicity and further develop the vaccine as a pandemic flu product...
  21. 6th Orthomyxovirus Research Conference
    STACEY L SCHULTZ-CHERRY; Fiscal Year: 2012
    ..for young scientists to present at the 6th Orthomyxoviruses Research Conference (affectionately termed the "Young Flu" meeting), which will be held outside Montreal, Canada September 19th - 22nd, 2012...
  22. Recombinant Subunit Protein for Flu Vaccine
    Carolyn Weeks Levy; Fiscal Year: 2006
    ..chicken eggs) inherently limit the amount of influenza vaccine that can be produced prior to each year's flu season. Most of the influenza vaccine sold is inactivated...
  23. Microcarrier culture system for human influenza vaccine
    WILLIAM HILLEGAS; Fiscal Year: 2004
    ..conditions there are long lead times between (a) the identification of particular virus strains likely in each flu season and (b) the availability of appropriate vaccines against these virus strains...
  24. Impact of Bilateral Priming on Response to Unilateral Flu Vaccination
    David Schwartz; Fiscal Year: 2009
    ..Results could lead to improved strategies for the administration and design of new vaccines, capable of inducing better long term immunity. ..
  25. V.I.P.: Vaccinate for Influenza Prevention
    George Kuchel; Fiscal Year: 2005
    ..In 2005-6, we will combine local formative research on barriers to flu vaccine with a theory driven, empowerment based intervention in a formative study that compares the short term ..
  26. Barcoded Magnetic Beads for Rapid Tests of MRSA and Respiratory Viral Panels
    WINSTON Z HO; Fiscal Year: 2010
    ..The 2009 Influenza A/H1N1, or "swine flu," pandemic occupied the time and attention of many...
  27. Identification of novel influenza antivirals
    GREGORY WILLIAM HENKEL; Fiscal Year: 2012
    ..Although vaccines provide significant protection from seasonal flu infections they still account for an estimated 36,000 deaths and 200,000 hospitalizations per year in the US alone...
  28. Respiratory Panel Flow-Strip: a Point-of-Care Molecular Diagnostic Test
    CHRISTOPHER GERARD COONEY; Fiscal Year: 2012
    ..g., one study found the sensitivity of a laterl flow immunoassay test for flu to be as low as 10.4%)...
  29. Peptide inhbitors of influenza entry-FAST TRACK
    Russell B Wilson; Fiscal Year: 2011
    ..in one to two weeks, the very young, the elderly and persons with chronic medical conditions can develop post-flu pneumonia and other lethal complications...
  30. Novel Vaccine Immunogens for Pandemic H5 Influenza
    ROBERT GERALD WHALEN; Fiscal Year: 2009
    ..We propose to create a collection of vaccine candidates that can rapidly be tested against an emerging pandemic. A strategy such as that proposed here could provide protection against a pandemic flu virus and save millions of lives.
  31. Xiaowei Zhuang; Fiscal Year: 2014
    ..this project, we will focus on the viral entry step, which is a promising target for drug inhibition and for anti-flu therapies...
  32. Ellis L Reinherz; Fiscal Year: 2015
    ..Such alterations adversely impact public health preparedness. The current swine flu H1N1 pandemic 2009 strain is a case in point...
  33. Development of drugs that target the M2 proton channel from the influenza A Virus
    William F Degrado; Fiscal Year: 2012
    ..In the last flu season, most strains of the influenza virus (including H5N1) have become resistant to the amantadine class of drugs,..
  34. Influenza therapy by Au-nanorod 5'PPP-NS1-siRNA/cDNA targeting of bronchial cells
    Paul R Knight; Fiscal Year: 2010
    ..significantly reduce the morbidity and severity of symptoms of influenza including the highly pathogenic H5N1 "bird flu" and the risk of secondary bacterial pneumonia, which is the major cause of death secondary to influenza...
  35. Susceptibility and Protective Immunity to Noroviruses
    Ralph S Baric; Fiscal Year: 2013
    ..Heralded as the "stomach flu", retirement community outbreaks are pervasive and can result in 1-2% mortality rates in the elderly...
  36. Michel G Bergeron; Fiscal Year: 2014
    ..Seventeen viruses, including influenza A (such as avian flu and swine flu), influenza B, SARS coronavirus, parainfluenza, and adenovirus responsible for the majority of VRTI ..
  37. Meditation and Exercise for Prevention of Acute Respiratory Infection
    Bruce P Barrett; Fiscal Year: 2010
    ..or moderately strenuous exercise can enhance immune processes such as antibody response to influenza vaccination (flu shots)...
  38. Virulence-Associated Proteins of Pathogenic Leptospira Species
    James Matsunaga; Fiscal Year: 2012
    ..b>Flu-like symptoms, often the only symptoms of early disease in leptospirosis, are characteristic of many infectious ..
  39. Structural insights into pandemic and emerging influenza viruses
    Ian A Wilson; Fiscal Year: 2013
    ..While neutralizing antibodies against human flu are traditionally regarded as being strain specific, recent studies have shown that a much broader response can be ..
  40. Donna L Farber; Fiscal Year: 2016
    ..pathology, and marked deficiencies in the production of T cell-derived effector cytokines in the lung compared to flu-infected adult mice...
  41. Influenza Therapeutics Using siRNA Nanoparticle Technology
    David M Evans; Fiscal Year: 2010
    ..However, a barrier for their use in flu is the validation of a vehicle that can deliver siRNAs to the appropriate site(s) needed for therapeutic benefit...
  42. Development of novel broad-spectrum influenza A inhibitors
    KEN J MCCORMACK; Fiscal Year: 2012
    ..While vaccines provide significant protection from seasonal flu infections they still account for an estimated 36,000 deaths and 200,000 hospitalizations per year in the US alone...
  43. Richard P Phipps; Fiscal Year: 2014
    ..Mice will be vaccinated using the trivalent seasonal flu vaccine, as well as influenza recombinant protein, hemagglutinin (HA), and complemented with or without SPM...
  44. Live attenuated vaccines for epidemic and pandemic flu
    Adolfo Garcia Sastre; Fiscal Year: 2010
    ..Finally, in collaboration with GreenHills Biotechnology, we will optimize cell culture techniques for the large-scale production of NS1-modified influenza virus vaccines suitable for use in humans. ..
  45. Hao Shen; Fiscal Year: 2016
    ..the most cost-effective biomedical approach for controlling these diseases, but developing and producing the flu vaccines in sufficient quantities has proved problematic...
  46. Manipulating natural host immunoregulation via IDO during viral Infection
    ANDREW LEE MELLOR; Fiscal Year: 2013
    The objective is to elucidate the effects of influenza (flu) virus infection and flu vaccines on a natural host T cell regulatory mechanism involving expression of indoleamine 2,3 dioxygenase (IDO)...
  47. Mucosal Immunotherapy in a mouse model of Alzheimer's Disease
    Howard L Weiner; Fiscal Year: 2010
    ..multiple sclerosis) combined with a proteosome based adjuvant that has been shown to be safe in humans as part of a flu vaccine...
  48. HPV Vaccine Education Intervention for Medically Underserved High-risk Population
    Armando Valdez; Fiscal Year: 2013
    ..tailored to 16 diverse audiences in four different languages (English, Spanish, Korean and Vietnamese) on a single Blu-ray disc...
  49. Development of a broadly neutralizing influenza virus vaccine
    Anette Schneemann; Fiscal Year: 2012
    ..Moreover, they do not account for the emergence of pandemic strains as exemplified by the H1N1 "swine flu" outbreak in 2009...
  50. Laura Haynes; Fiscal Year: 2016
    ..Project 1 "Impact of aging on CD4 immunity to flu" will examine the impact of age on CD4 T cell primary and memory responses and if this can be enhanced...
  51. Novel Formulation of Flu Vaccine for the Aged
    Jiu Jiang; Fiscal Year: 2012
    ..Immunization with flu vaccine is considered the best way to prevent seasonal epidemics and pandemics of influenza...
  52. Real-time detection and identification of single viruses
    Lukas Novotny; Fiscal Year: 2011
    ..Viruses are responsible for a considerable number of human diseases such as chickenpox or the common flu. In some cases (Ebola, AIDS, SARS,) viral pathogens result in serious disease or even death...
  53. Development of a Bacteriophage Vaccine Vector System
    STEVE BENDE; Fiscal Year: 2010
    ..and application of a bacteriophage vector system (BVS) platform expressing influenza A virus-like particles (Flu-VLPs)...
  54. Agonists of the RIG-I Innate Immune Pathway
    SHAWN PATRICK IADONATO; Fiscal Year: 2013
    ..response pathways and inhibit the replication of RNA viruses such as hepatitis C virus (HCV), influenza virus (FLU), and West Nile virus (WNV)...
  55. F Nina Papavasiliou; Fiscal Year: 2015
    ..g. HIV) or even long lasting, protective vaccines against common diseases (e.g. flu). Despite many years of basic research, the reasons why most vaccines fail are not understood...
  56. Using the Default Effect to Promote Healthy Behavior
    Gretchen B Chapman; Fiscal Year: 2012
    ..Field studies in each domain will examine real-life health behavior under both opt-in and opt-out defaults. In the flu shot study, outpatients will be automatically scheduled for a flu shot appointment (with the option to opt out) or ..
  57. Mei X Wu; Fiscal Year: 2015
    ..of concept evidence that a newly-developed prototype laser system can result in dose-sparing of existing influenza (flu) vaccines without any additives...
  58. Enhanced Oral Vaccine Delivery Vehicle
    Sean N Tucker; Fiscal Year: 2011
    ..from these aims will provide the pre-clinical data required to begin clinical testing of Vaxart's oral avian flu vaccine...
  59. Kevin G Volpp; Fiscal Year: 2016
    ..that impact the health of elderly Americans, focusing on improving diabetes control among veterans, calorie consumption in restaurants, exercise among the elderly, and flu shot vaccination rates among hospital employees.
  60. The Sumoylation System as a Novel Target for Anti-Influenza Therapies
    German Rosas Acosta; Fiscal Year: 2010
    ..could lead to the development of novel anti-influenza therapies potentially applicable to the treatment of pandemic flu and other viral diseases...
  61. The Effect of Fact versus Myth Messages on Receipt of Influenza Vaccination
    KENZIE CAMERON; Fiscal Year: 2009
    ..Interventions to increase vaccination rates include printed educational materials, such as the CDC's "Flu Vaccine Facts &Myths...
  62. Jessica Healy; Fiscal Year: 2014
    ..Humans infected with WNV may experience a range of symptoms, from flu-like febrile illness to neuroinvasive disease, often termed West Nile Neuroinvasive disease (WNND)...
  63. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..There are also a number of emerging viruses such as West Nile and the breaking Mexican swine flu, and a number of potential bioterrorism pathogens such as smallpox that are of concern to the safety of the human ..
  64. A Longitudinal Study of Influenza Vaccine Decisions
    Gretchen Chapman; Fiscal Year: 2004
    ..health behavior because it both saves money and prevents the considerable morbidity and mortality caused by the flu. Unlike most previous studies of flu shot acceptance, the current study will use a longitudinal design over three ..
  65. Formulated Patch for Topical Influenza Vaccine
    Gregory Glenn; Fiscal Year: 2004
    ..This phase I SBIR proposal will focus on the development of a dry self-adhesive flu vaccine patch, which can be manufactured (cGMP) and is practical to apply in the clinic...
  66. Rapid point-of-care diagnostic for bioterrorism "A" agents and Pandemic influenza
    Kelly J Henrickson; Fiscal Year: 2010
    ..Another agent of grave concern is influenza (Flu) (Category "C")...
  67. AvanceIII 700MHz NMR spectrometer with cryogenic probe
    James J Chou; Fiscal Year: 2010
    ..the structure of the BM2 H+ channel of influenza B virus, for providing structural details for designing new anti-flu compounds...
  68. Development of Diagnostic Microarray for Influenza A
    KATHY ROWLEN; Fiscal Year: 2007
    ..We will take advantage of functional genomics by developing a DNA microarray, the "Flu Chip," that will provide information as to whether or not an individual is infected with influenza as well as ..
  69. Identification and Analysis of Flavivirus Protease and RNA Helicase Inhibitors
    Radhakrishnan Padmanabhan; Fiscal Year: 2009
    ..These viruses, in addition to flu-like symptoms, can cause hemorrhagic fevers (YFV and DEN) or encephalitis and/or meningo-encephalitis in ..
  70. Functional Characterization of Coxiella burnetii Dot/Icm Substrates
    Daniel E Voth; Fiscal Year: 2010
    ..Q fever typically presents as an acute debilitating flu-like illness but can progress to severe, chronic endocarditis. In host cells, C...
  71. Development of an Inhibitor of Toxoplasma gondii
    Richard D Wood; Fiscal Year: 2010
    ..infection is often undiagnosed or misdiagnosed because infected persons either experience lymphadenopathy or flu-like symptoms. Chronic infection occurs in approximately 1/3 to 1/2 of the world population (i.e...
  72. Peptide drugs against influenza virus
    Robert Garry; Fiscal Year: 2007
    ..Centers for Disease Control and Prevention have declared that it is only a matter of time before the next worldwide flu pandemic. The new strains of bird flu appear to be resistant to amantadine and related influenza drugs...
  73. Neurological sequelae in survivors of West Nile virus infection: a hamster model
    Cynthia Smeraski; Fiscal Year: 2009
    ..humans, West Nile virus (WNV) infection varies in its severity: from no overt symptoms, to a general malaise with flu-like symptoms, to severe, potentially fatal meningoencephalitis...
  74. Mechanistic studies and inhibition strategies for antibiotic resistance
    Focco van den Akker; Fiscal Year: 2010
    ..Furthermore, viral infections such as the flu are frequently accompanied by bacterial infections which is often a deadly combination...
  75. BABESIOSIS AS A PARADIGM FOR THE EFFECTS OF AGING
    JEFFREY GELFAND; Fiscal Year: 2000
    ..B. microti infection usually causes a mild, flu-like illness in young, immunologically normal patients...
  76. PREVENTION OF LYME DISEASE--RANDOMIZED CLINICAL TRIAL
    Eugene Shapiro; Fiscal Year: 1991
    ..Patients with Lyme disease typically suffer from an acute flu-like illness associated with a characteristic annular rash (erythema migrans)...
  77. In-ovo vaccination/avian influenza/bird/human
    DE CHU TANG; Fiscal Year: 2006
    ..and rapid method for disrupting the poultry-to- human transmission of avian influenza by in ovo injection of flu vaccines that can be mass- administered with a mechanized injector...
  78. Social Network-Enabled Flu Trends (SNEFT)Integrating Online Social Network Data
    Lingji Chen; Fiscal Year: 2010
    ..Already, Google Flu Trends uses web search terms such as "influenza complication" and "cold remedy" collectively to predict the onset ..
  79. Nucleic Acid Dipstick for Rapid Avian Flu Detection at Point-of-care
    Hong Cai; Fiscal Year: 2009
    ..pen sizes, like those home pregnancy test strip sold in stores) capable of detecting and distinguishing multiple flu-like symptom pathogens (e.g...