BHLHE40

Summary

Gene Symbol: BHLHE40
Description: basic helix-loop-helix family member e40
Alias: BHLHB2, Clast5, DEC1, HLHB2, SHARP-2, SHARP2, STRA13, Stra14, class E basic helix-loop-helix protein 40, basic helix-loop-helix domain containing, class B, 2, class B basic helix-loop-helix protein 2, differentially expressed in chondrocytes 1, differentially expressed in chondrocytes protein 1, differentiated embryo chondrocyte expressed gene 1, enhancer-of-split and hairy-related protein 2, stimulated by retinoic acid gene 13 protein
Species: human

Top Publications

  1. ncbi Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway
    A V Ivanova
    Laboratory of Immunobiology, NCI Frederick Cancer Research Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 276:15306-15. 2001
  2. ncbi Gene expression of basic helix-loop-helix transcription factor, SHARP-2, is regulated by gonadotropins in the rat ovary and MA-10 cells
    Kazuya Yamada
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Biol Reprod 70:76-82. 2004
  3. doi Liver X receptors (LXRalpha and LXRbeta) are potent regulators for hepatic Dec1 expression
    Mitsuhide Noshiro
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Genes Cells 14:29-40. 2009
  4. doi Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells
    Yang Liu
    Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Genes Cells 15:315-25. 2010
  5. pmc Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms
    H Sun
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Proc Natl Acad Sci U S A 97:4058-63. 2000
  6. ncbi Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2
    M Teramoto
    Department of Biochemistry, Hiroshima University School of Dentistry, Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    J Biochem 129:391-6. 2001
  7. ncbi Identification of genes differentially induced by hypoxia in pancreatic cancer cells
    D Y Yoon
    Department of Pathology, University of California, Los Angeles 90095, USA
    Biochem Biophys Res Commun 288:882-6. 2001
  8. pmc Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation
    Yuxin Li
    Department of Biomedical Sciences, University of Rhode Island, Kingston, RI 02881, U S A
    Biochem J 367:413-22. 2002
  9. ncbi Stra13 homodimers repress transcription through class B E-box elements
    Benoit St-Pierre
    Programs in Cancer Research and Developmental Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 277:46544-51. 2002
  10. ncbi Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes
    Kazuko Miyazaki
    Department of Dental and Medical Biochemistry, Graduate School of Biomedical Sciences, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
    J Biol Chem 277:47014-21. 2002

Research Grants

  1. Mechanism of p63-Dependent Tumor Suppression
    Xinbin Chen; Fiscal Year: 2012
  2. Xinbin Chen; Fiscal Year: 2015
  3. Laura Shaw; Fiscal Year: 2016
  4. Molecular mechanism of ID1 function in advanced breast cancer
    Meiyun Fan; Fiscal Year: 2013
  5. Christine Schwartz; Fiscal Year: 2014
  6. Isl1 and Wntbeta-catenin regulation of cardiac progenitor cells
    Chulan Kwon; Fiscal Year: 2010
  7. Molecular basis of differentiation and growth control
    Reshma Taneja; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications165 found, 100 shown here

  1. ncbi Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway
    A V Ivanova
    Laboratory of Immunobiology, NCI Frederick Cancer Research Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 276:15306-15. 2001
    In this study, we focus on different modes of regulation of STRA13, a human ortholog of the mouse basic helix-loop-helix transcriptional factor, previously identified by us as a new von Hippel-Lindau tumor suppressor gene (VHL) target...
  2. ncbi Gene expression of basic helix-loop-helix transcription factor, SHARP-2, is regulated by gonadotropins in the rat ovary and MA-10 cells
    Kazuya Yamada
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Biol Reprod 70:76-82. 2004
    ..We conclude that the level of SHARP-2 mRNA is regulated by gonadotropins and that SHARP-2 functions as a transcriptional repressor localized in the nucleus...
  3. doi Liver X receptors (LXRalpha and LXRbeta) are potent regulators for hepatic Dec1 expression
    Mitsuhide Noshiro
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Genes Cells 14:29-40. 2009
    DEC1 (BHLHB2/Stra13/Sharp2)-a basic helix-loop-helix transcription factor-is known to be involved in various biological phenomena including clock systems and metabolism...
  4. doi Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells
    Yang Liu
    Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Genes Cells 15:315-25. 2010
    DEC1 (BHLHB2/Stra13/Sharp2) and DEC2 (BHLHB3/Sharp1) are basic helix-loop-helix (bHLH) transcription factors that are involved in circadian rhythms, differentiation and the responses to hypoxia...
  5. pmc Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms
    H Sun
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Proc Natl Acad Sci U S A 97:4058-63. 2000
    b>Stra13 is a transcriptional repressor related within its basic helix-loop-helix domain with the Drosophila Hairy, Enhancer of Split, and the mouse Hes1 proteins that interact with the corepressor Groucho...
  6. ncbi Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2
    M Teramoto
    Department of Biochemistry, Hiroshima University School of Dentistry, Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    J Biochem 129:391-6. 2001
    DEC1/BHLHB2 is a novel cAMP-inducible basic helix-loop-helix (bHLH) transcriptional factor isolated from human chondrocyte cultures by the subtraction method [Shen et al. (1997) Biochem. Biophys. Res. Commun. 236, 294--298]...
  7. ncbi Identification of genes differentially induced by hypoxia in pancreatic cancer cells
    D Y Yoon
    Department of Pathology, University of California, Los Angeles 90095, USA
    Biochem Biophys Res Commun 288:882-6. 2001
    ..In addition, hexokinase II and DEC1/Stra13, genes known to be hypoxia inducible in other systems, were found to be hypoxia inducible in our pancreatic cancer ..
  8. pmc Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation
    Yuxin Li
    Department of Biomedical Sciences, University of Rhode Island, Kingston, RI 02881, U S A
    Biochem J 367:413-22. 2002
    ..The present study describes the functional characterization of DEC1. Subtractive experiments and blotting analyses demonstrated that DEC1 was highly expressed in colon carcinomas, but ..
  9. ncbi Stra13 homodimers repress transcription through class B E-box elements
    Benoit St-Pierre
    Programs in Cancer Research and Developmental Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 277:46544-51. 2002
    A mammalian basic helix-loop-helix protein known variably as Stra13, Sharp2, and Dec1 has been implicated in cell activation, proliferation, and differentiation...
  10. ncbi Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes
    Kazuko Miyazaki
    Department of Dental and Medical Biochemistry, Graduate School of Biomedical Sciences, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
    J Biol Chem 277:47014-21. 2002
    ..e. in chondrocytes) and pathologically (i.e. in tumor cells). Previous studies have shown that DEC1, a basic helix-loop-helix transcription factor, is induced by hypoxia in glioma cells (Ivanova, A. V., Ivanov, S. V...
  11. ncbi Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages
    Ming Shen
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    J Biol Chem 277:50112-20. 2002
    The mRNA level of basic helix-loop-helix transcription factor DEC1 (BHLHB2)/Stra13/Sharp2 was up-regulated during chondrocyte differentiation in cultures of ATDC5 cells and growth plate chondrocytes, and in growth plate cartilage in vivo...
  12. ncbi Dec1 and Dec2 are regulators of the mammalian molecular clock
    Sato Honma
    Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Nature 419:841-4. 2002
    ..We found that Dec1 and Dec2, basic helix-loop-helix transcription factors, repressed Clock/Bmal1-induced transactivation of the mouse ..
  13. ncbi DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter
    Yuxin Li
    Department of Biomedical Sciences, University of Rhode Island, Kingston, Rhode Island 02881, USA
    J Biol Chem 278:16899-907. 2003
    ..Recently, we have reported that DEC1 is abundantly expressed in colon carcinomas but not in the adjacent normal tissues...
  14. ncbi DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer
    Alexandra Giatromanolaki
    Departments of Pathology and Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis 68100, Greece
    J Pathol 200:222-8. 2003
    Differentiated embryo-chondrocyte expressed gene 1 (DEC1) is involved in cell differentiation, proliferation, and apoptosis, and was recently shown to be regulated by hypoxia...
  15. ncbi STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets
    A V Ivanova
    Basic Research Program, SAIC Frederick Inc, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    J Mol Biol 340:641-53. 2004
    b>STRA13 is a pVHL-dependent bHLH transcription factor up-regulated on the mRNA level in multiple cancer cell lines and implicated recently in the regulation of immune cell homeostasis and autoimmunity...
  16. pmc STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker
    A Ivanova
    Laboratory of Immunobiology, Basic Research Program, SAIC Frederick Inc, NCI Frederick, Maryland, USA
    J Med Genet 42:565-76. 2005
    b>STRA13 is a bHLH transcription factor that plays a crucial role in cell differentiation, proliferation, apoptosis, and response to hypoxia.
  17. pmc The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter
    Y Li
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, 02881, USA
    Oncogene 25:3296-306. 2006
    ..b>DEC1 is abundantly expressed in tumors and protects against apoptosis induced by serum starvation...
  18. ncbi Hypoxic repression of STAT1 and its downstream genes by a pVHL/HIF-1 target DEC1/STRA13
    S V Ivanov
    Basic Research Program, SAIC Frederick, Inc, Frederick, MD 21702, USA
    Oncogene 26:802-12. 2007
    DEC1/STRA13 is a bHLH type transcriptional regulator involved with immune regulation, hypoxia response and carcinogenesis...
  19. ncbi Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements
    Katsumi Fujimoto
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Int J Mol Med 19:925-32. 2007
    ..Gel retardation and luciferase assays showed that Dec2, as well as its related protein Dec1, preferentially binds to class B E-box elements (CACGTG) as a homodimer and represses the transcription of target ..
  20. pmc DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence
    Yingjuan Qian
    University of California Davis, Center for Comparative Oncology, Davis, CA 95616, USA
    J Biol Chem 283:2896-905. 2008
    ..Among the many candidates is DEC1, a basic helix-loop-helix transcription factor that has been recently shown to be up-regulated in K-ras-induced ..
  21. doi Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2
    H Nakamura
    Department of Translational Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Oncogene 27:4200-9. 2008
    ..gene, MLH1, and demonstrated that hypoxia-inducible transcription repressors, differentiated embryo chondrocytes (DEC1 and 2), participated in its transcriptional regulation via their bindings to E-box-like motif(s) in MLH1 promoter ..
  22. pmc DEC1 modulates the circadian phase of clock gene expression
    Ayumu Nakashima
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Mol Cell Biol 28:4080-92. 2008
    b>DEC1 suppresses CLOCK/BMAL1-enhanced promoter activity, but its role in the circadian system of mammals remains unclear...
  23. doi The hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and its expression in gastric cancer
    Yan Zheng
    Central Laboratory, Jinan Central Hospital affiliated to Shandong University, Jinan, People s Republic of China
    OMICS 13:301-6. 2009
    Differentiated embryo-chondrocyte expressed gene 1 (DEC1), as a bHLH transcriptional factor, plays important roles in cell differentiation, proliferation, and apoptosis...
  24. doi The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors
    Yoshitake Cho
    Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi ku, Tokyo, Japan
    Mol Pharmacol 76:1360-9. 2009
    The basic helix-loop-helix proteins differentiated embryo chondrocyte 1 (DEC1) and DEC2 are involved in circadian rhythm control...
  25. doi Hypoxia inducible BHLHB2 is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma
    Weibin Wang
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Biochem Biophys Res Commun 401:422-8. 2010
    ..adenosine monophosphate-inducible basic helix-loop-helix (bHLH) domain containing class-B2 transcriptional factor BHLHB2 is differentially expressed in a number of human malignancies...
  26. pmc DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation
    Yingjuan Qian
    From the Comparative Oncology Laboratory, University of California, Davis, California 95616, USA
    J Biol Chem 286:12033-41. 2011
    ..Here, we showed that ΔNp63 is regulated by the transcription factor DEC1, a p53 family target...
  27. pmc DEC1 nuclear expression: a marker of differentiation grade in hepatocellular carcinoma
    Xiao Hong Shi
    Department of Laboratory Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China
    World J Gastroenterol 17:2037-43. 2011
    To investigate the expression patterns of human differentiated embryo chondrocyte 1 (DEC1) in hepatocellular carcinoma (HCC) and corresponding adjacent non-tumor and the normal liver tissues, the association between DEC1 expression and ..
  28. doi The increased expression of DEC1 gene is related to HIF-1α protein in gastric cancer cell lines
    Yan Zheng
    Central Laboratory, Jinan Central Hospital affiliated to Shandong University, Jinan, 250013, People s Republic of China
    Mol Biol Rep 39:4229-36. 2012
    Overexpression of differentiated embryo chondrocyte 1 (DEC1) has been reported to contribute to the cellular differentiation, proliferation, and apoptosis of various cancers...
  29. pmc SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability
    Yongde Hong
    School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China
    PLoS ONE 6:e23046. 2011
    Differentiated embryo-chondrocyte expressed gene 1 (DEC1, also known as sharp2, stra13, or BHLHB2) is a mammalian basic helix-loop-helix protein that is involved in many aspects of gene regulation through acting as a transcription factor...
  30. pmc Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1
    Yingjuan Qian
    Comparative Cancer Center, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 109:11300-5. 2012
    ..Previously, we showed that DEC1, a basic helix-loop-helix transcription factor and a target of p53, is capable of inducing cell cycle arrest and ..
  31. doi The BHLH transcription factor DEC1 plays an important role in the epithelial-mesenchymal transition of pancreatic cancer
    Yunyan Wu
    Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Int J Oncol 41:1337-46. 2012
    DEC1 (BHLHE40/Stra13/Sharp2) is a basic helix-loop-helix (bHLH) transcription factor that is involved in the regulation of apoptosis and cell proliferation and the response to hypoxia...
  32. doi DEC1 is positively associated with the malignant phenotype of invasive breast cancers and negatively correlated with the expression of claudin-1
    Yang Liu
    Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang 110001, PR China
    Int J Mol Med 31:855-60. 2013
    Differentiated embryo-chondrocyte expressed gene 1 (DEC1) is a basic helix-loop-helix transcriptional regulator, reportedly involved in cell growth, differentiation, apoptosis and tumorigenesis...
  33. pmc DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1
    Yuxin Li
    Department of Biomedical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Biochem J 382:895-904. 2004
    DEC1 (differentially expressed in chondrocytes 1) and DEC2 are E-box-binding transcription factors and exhibit a circadian expression pattern. Recently, both proteins were found to repress the Clock/Bmal1-activated E-box promoters (e.g...
  34. ncbi Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1
    Fuyuki Sato
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Eur J Biochem 271:4409-19. 2004
    The basic helix-loop-helix transcription factor DEC1 is expressed in a circadian manner in the suprachiasmatic nucleus where it seems to play a role in regulating the mammalian circadian rhythm by suppressing the CLOCK/BMAL1-activated ..
  35. pmc Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis
    Tin Htwe Thin
    Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    EMBO Rep 8:401-7. 2007
    ..In this study, we have identified stimulated with retinoic acid 13 (Stra13), a basic helix-loop-helix transcription factor, as a regulator of ionizing-radiation-induced apoptosis...
  36. ncbi Embryo-chondrocyte expressed gene 1, downregulating hypoxia-inducible factor 1alpha, is another marker of lung tumor hypoxia
    Li Zhang
    Department of Respiratory Disease, Renmin Hospital, Wuhan University, Wuhan 430060, China
    Acta Pharmacol Sin 28:549-58. 2007
    To explore the mechanism of differentiated embryo-chondrocyte expressed gene 1 (DEC1) in the lung adenocarcinoma A549 cell line and its relationship with hypoxia-inducible factor 1alpha(HIF-1alpha).
  37. pmc Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1047-55. 2008
    ..and TIMELESS) in a family collection of 36 trios and 79 quads (Sample I), and 10 circadian genes (ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CSNK1D, CSNK1E, DBP, and NR1D1) in an extended family collection of 70 trios and 237 quads (..
  38. ncbi A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation
    Takeshi Kawamoto
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Biochem Biophys Res Commun 313:117-24. 2004
    ..We show here an autofeedback loop of Dec1 encoding a basic helix-loop-helix transcription factor: CLOCK/BMAL increased the promoter activity of Dec1, and ..
  39. ncbi Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes
    M Shen
    Department of Biochemistry, Hiroshima University School of Dentistry, Japan
    Biochem Biophys Res Commun 236:294-8. 1997
    ..Using this culture system, a novel human cDNA for a basic helix-loop-helix (bHLH) protein (named DEC1) expressed primarily in the chondrocytes in response to Bt2cAMP was cloned by the subtractive hybridization method...
  40. ncbi PTHrP promotes murine secondary trophoblast giant cell differentiation through induction of endocycle, upregulation of giant-cell-promoting transcription factors and suppression of other trophoblast cell types
    Ahmed H K El-Hashash
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Differentiation 73:154-74. 2005
    ..TGC differentiation by inducing the expression of transcription factors known to stimulate giant cell formation: Stra13 and AP-2gamma, and inhibiting the formation of other trophoblast cell types by suppressing trophoblast progenitors ..
  41. doi Activation of TGF-beta/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts
    Naohiro Kon
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Cell Biol 10:1463-9. 2008
    ..The resetting was mediated by an immediate-early induction of Dec1, a gene whose physiological role in the function of the circadian clock has been unclear...
  42. ncbi Activation of 5-HT2C receptors acutely induces Per gene expression in the rat suprachiasmatic nucleus at night
    Tamara J Varcoe
    Department of Obstetrics and Gynaecology, University of Adelaide Medical School, Frome Road, Adelaide 5005, South Australia, Australia
    Brain Res Mol Brain Res 119:192-200. 2003
    ..The expression of Per1, Per2, Cry1, Clock, Bmal1, Dec1, Dec2 and c-fos was determined 30 and 120 min after treatment in suprachiasmatic nucleus punches by real time ..
  43. pmc Molecular signatures reveal circadian clocks may orchestrate the homeorhetic response to lactation
    Theresa Casey
    Department of Animal Science, Michigan State University, East Lansing, Michigan, USA
    PLoS ONE 4:e7395. 2009
    ..Commonly down regulated genes enriched Rhythmic process and included: NR1D1, DBP, BHLHB2, OPN4, and HTR7, which regulate intracellular circadian rhythms...
  44. ncbi Adrenal transcription regulatory genes modulated by angiotensin II and their role in steroidogenesis
    Damian G Romero
    Division of Endocrinology, G V Sonny Montgomery Veterans Affairs Medical Center, Jackson, Mississippi, USA
    Physiol Genomics 30:26-34. 2007
    ..b>BHLHB2, BTG2, and SALL1 decreased expression of both enzymes, whereas CITED2, EGR2, ELL2, FOS, FOSB, HDAC5, MAFF, MITF, ..
  45. pmc Angiotensin II-regulated transcription regulatory genes in adrenal steroidogenesis
    Damian G Romero
    Endocrinology, G V Sonny Montgomery Department of Veterans Affairs Medical Center, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Physiol Genomics 42:259-66. 2010
    ..BCL11B, BHLHB2, CITED2, ELL2, HMGA1, MAFF, NFIL3, PER1, SERTAD1, and VDR significantly stimulated aldosterone secretion, while ..
  46. pmc Hyperosmolar stress induces global mRNA responses in placental trophoblast stem cells that emulate early post-implantation differentiation
    J Liu
    C S Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Placenta 30:66-73. 2009
    ..But, stress also induced transcription factors that mediate TSC differentiation to trophoblast giant cells (TGC) (Stra13, HES1, GATA-binding2), placental hormones [proliferin, placental lactogen (PL)1, prolactin-like protein (PLP)M], ..
  47. ncbi Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 31:461-6. 2007
    ..into HES subfamily (HES1, HES2, HES3, HES4, HES5, HES6, HES7) and HEY subfamily (HEY1, HEY2, HEYL, HESL/HELT, DEC1/BHLHB2, DEC2/BHLHB3)...
  48. pmc Fetal exposure to cocaine causes programming of Prkce gene repression in the left ventricle of adult rat offspring
    Haitao Zhang
    Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, California, USA
    Biol Reprod 80:440-8. 2009
    ..CpG dinucleotides identified in Bhlhb2, Pparg, E2f, and Egr1 binding sites at the Prkce gene promoter were densely methylated in males and females and ..
  49. pmc PI-3 kinase pathway can mediate the effect of TGF-beta1 in inducing the expression of SHARP-2 in LLC-PK1 cells
    Zhang fei Shou
    Kidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
    J Zhejiang Univ Sci B 10:702-6. 2009
    ..The effect of LY294002 was dose-dependent. We conclude that, in LLC-PK1 cells at least, TGF-beta1 can effectively induce the SHARP-2 mRNA expression and that the PI-3 kinase pathway can mediate this effect...
  50. pmc Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo
    Dawn K Coletta
    Division of Diabetes, Department of Medicine, University of Texas Health Science Centre, San Antonio, TX, USA
    Am J Physiol Endocrinol Metab 294:E910-7. 2008
    ..increased the mRNAs of a number of inflammatory genes (CCL2, CXCL2 and THBD) and transcription factors (ATF3, BHLHB2, HES1, KLF10, JUNB, FOS, and FOSB)...
  51. doi Identification and developmental expression of Dec2 in zebrafish
    Li Chen
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    Fish Physiol Biochem 36:667-75. 2010
    ..The embryonic expression patterns of zebrafish Dec2 and its homolog Dec1 partially overlap, but are distinct from each other...
  52. doi Possible involvement of DEC1 on the adverse effects of quinolone antibiotics
    Xiaohong Shi
    Department of Laboratory Medicine, Qianfoshan Hospital, Shandong University, 66 Jingshi Road, Jinan 250014, PR China
    Toxicology 271:1-4. 2010
    ..Differentiated embryo-chondrocyte expressed gene 1 (DEC1), an important transcription factor that has a basic helix-loop-helix domain and is ubiquitously expressed in both ..
  53. doi Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression
    Fuyuki Sato
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Genes Cells 13:131-44. 2008
    DEC1 (BHLHB2/Sharp2/Stra13) and DEC2 (BHLHB3/Sharp1) are basic-helix-loop-helix (bHLH) transcription factors, involved in cellular differentiation, responses to hypoxia and circadian rhythms...
  54. doi Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells
    Malin Pedersen
    Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    Biochem Biophys Res Commun 377:98-103. 2008
    ..HIF-1alpha was transcriptionally active, and transcribed HIF-1 target genes such as VEGF, BNIP3, GLUT1 and DEC1, an effect that could be reversed by siRNA against HIF-1alpha...
  55. ncbi Atrial appendage transcriptional profile in patients with atrial fibrillation with structural heart diseases
    Maria S Kharlap
    Clinical Electrophysiology Department, The A L Myasnikov Institute of Clinical Cardiology, Cardiology Research and Production Center, 121 552, 3 d Cherepkovskaya Street 15 A, Moscow, Russia
    Ann N Y Acad Sci 1091:205-17. 2006
    ..The greatest alterations were observed for NOR1, DEC1, MSF, and Bcl2A1 genes (5 to 28-fold decrease, P < 0.05)...
  56. doi Transcriptional feedback loops in the ovine circadian clock
    Hugues Dardente
    School of Biological Sciences, Tillydrone Avenue, Aberdeen University, Scotland, UK
    Comp Biochem Physiol A Mol Integr Physiol 153:391-8. 2009
    ..b>DEC1 has bidirectional transcriptional effects, repressor or activator, according to the promoter...
  57. ncbi Tissue-specific disruption of rhythmic expression of Dec1 and Dec2 in clock mutant mice
    Mitsuhide Noshiro
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Biol Rhythms 20:404-18. 2005
    b>DEC1 and DEC2-basic helix-loop-helix transcription factors-exhibit a circadian expression in the suprachiasmatic nucleus and other peripheral tissues and seem to play roles in regulating the mammalian circadian rhythm by suppressing the ..
  58. ncbi Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma
    Alfred Chi Chung Leung
    Department of Biology and Center for Cancer Research, Hong Kong University of Science and Technology, Hong Kong SAR, People s Republic of China
    Int J Cancer 122:587-94. 2008
    Previous studies showed that expression of the novel candidate tumor suppressor gene, DEC1 (Deleted in Esophageal Cancer 1), is reduced in esophageal carcinoma and suppresses cancer cell growth in vitro and tumor growth in vivo in nude ..
  59. pmc Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice
    Moritz J Rossner
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    PLoS ONE 3:e2762. 2008
    ..However, the molecular mechanisms leading to the disintegration of tissue-specific clocks are complex and not well understood...
  60. ncbi Dynamic regulation of the Stra13/Sharp/Dec bHLH repressors in mammary epithelium
    Benoit St-Pierre
    Programs in Cancer Research and Developmental Biology, The Hospital for Sick Children, and Department of Molecular and Medical Genetics, The University of Toronto, Toronto, Ontario, Canada
    Dev Dyn 230:124-30. 2004
    ..In this study, we have determined that expression of the Stra13/Sharp/Dec basic helix-loop-helix (bHLH) family is dynamically regulated in mammary epithelium...
  61. ncbi Basic helix-loop-helix transcription factors, BHLHB2 and BHLHB3; their gene expressions are regulated by multiple extracellular stimuli
    Kazuya Yamada
    Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Japan
    Front Biosci 10:3151-71. 2005
    ..Of the basic helix-loop-helix (bHLH) proteins binding to the E box sequence, class B of bHLH proteins, BHLHB2 (also referred to as the DEC1/Eip1/SHARP-2/Stra13/Clast5) and BHLHB3 (also referred to as the DEC2/SHARP-1/SHARP1),..
  62. ncbi Molecular analysis of Dec1 and Dec2 in the peripheral circadian clock of zebrafish photosensitive cells
    Tomotaka Abe
    Department of Biotechnology, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchu shi, Tokyo 183 8509, Japan
    Biochem Biophys Res Commun 351:1072-7. 2006
    To elucidate the roles of DEC1 and DEC2, basic helix-loop-helix transcription factors, in the circadian clock of photosensitive zebrafish peripheral cells, zebrafish Dec1 and Dec2 (zDec1 and zDec2) were cloned and their functions and ..
  63. pmc Stra13 regulates satellite cell activation by antagonizing Notch signaling
    Hong Sun
    Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 177:647-57. 2007
    ..We report that the basic helix-loop-helix transcription factor Stra13 modulates Notch signaling in regenerating muscle...
  64. doi Regulation of lipogenesis via BHLHB2/DEC1 and ChREBP feedback looping
    Katsumi Iizuka
    Laboratory of Medical Genomics, The Institute for Molecular and Cellular Regulation, Gunma University, Maebashi shi Gunma 371 8512, Japan
    Biochem Biophys Res Commun 374:95-100. 2008
    b>BHLHB2/DEC1 is a transcription factor implicated in cell proliferation, apoptosis, and metabolism, and is also known to play an important role in the regulation of the mammalian circadian rhythm...
  65. ncbi SHARP-2 gene silencing by lentiviral-based short hairpin RNA interference prolonged rat kidney transplant recipients' survival time
    Z Shou
    Kidney Disease Centre, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, China
    J Int Med Res 37:766-78. 2009
    ..In conclusion, recombinant lentiviral LV-SHARP-2iC construct effectively silenced SHARP-2 gene expression, which reduced IL-2 and IFN-gamma mRNA expression and prolonged rat kidney transplant recipients' survival...
  66. pmc A novel functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck
    Yu Jing Huang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 31:2082-90. 2010
    Human DEC1 (deleted in esophageal cancer 1) gene is located on chromosome 9q, a region frequently deleted in various types of human cancers, including squamous cell carcinoma of the head and neck (SCCHN)...
  67. doi The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells
    Kazuko Miyazaki
    Department of Developmental Biology, Research Institute for Radiation Biology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Immunol 185:7330-9. 2010
    ..In this paper, we report that the basic helix-loop-helix transcription factor Dec1 is involved in the homeostasis of Treg cells and plays a role in their survival or expansion after adoptive ..
  68. ncbi Dec1 and Dec2 expression is disrupted in the suprachiasmatic nuclei of Clock mutant mice
    Matthew Preston Butler
    Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Biol Rhythms 19:126-34. 2004
    b>DEC1 and DEC2 are basic helix-loop-helix transcription factors that functionally resemble negative feedback components of the mammalian circadian clock...
  69. ncbi SHARP-2/Stra13/DEC1 as a potential repressor of phosphoenolpyruvate carboxykinase gene expression
    Kazuya Yamada
    Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    FEBS Lett 579:1509-14. 2005
    ..Based on these findings, we conclude that SHARP-2 is a potential repressor of PEPCK gene expression...
  70. ncbi Transforming growth factor-beta promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1
    Shogo Ehata
    Department of Biochemistry, Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo, Japan
    Cancer Res 67:9694-703. 2007
    ..In the present study, we identified differentially expressed in chondrocytes 1 (DEC1, also known as SHARP2 and Stra13) as a downstream target of TGF-beta signaling, which ..
  71. doi Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
    S Rome
    INRA 1235, INSERM 870, INSA Lyon, Régulations Métaboliques Nutrition et Diabète, Universite de Lyon, Oullins, 69600, France
    Diabetologia 52:1899-912. 2009
    ..The aim of the present study was to gain a greater insight into this issue through the identification of transcription factor genes with insulin-regulated expression in human skeletal muscle...
  72. doi Myogenic regulatory factors regulate M-cadherin expression by targeting its proximal promoter elements
    Sheng Pin Hsiao
    Department of Life Sciences, National Central University, Jhongli 32054, Taiwan
    Biochem J 428:223-33. 2010
    ..The activation of the M-cadherin promoter by MRFs was also modulated by Bhlhe40 (basic helix-loop-helix family member e40)...
  73. ncbi Genistein stimulates the insulin-dependent signaling pathway
    Ayumi Haneishi
    Department of Health and Nutritional Science, Faculty of Human Health Science, Matsumoto University, Matsumoto, Nagano, Japan
    Front Biosci (Elite Ed) 3:1534-40. 2011
    ..Our results suggest that genistein might be a useful dietary supplement to control insulin-independent diabetes mellitus by inducing the SHARP-2 expression via a bypass of the insulin-dependent signaling pathway...
  74. doi IL-1β-mediated up-regulation of DEC1 in human gingiva cells via the Akt pathway
    Ujjal K Bhawal
    Department of Biochemistry and Molecular Biology, Nihon University School of Dentistry at Matsudo, Matsudo, Japan
    J Cell Biochem 113:3246-53. 2012
    ..However, pathways involved in this progression are not well understood. The involvement of DEC1 in cancer prompted us to examine whether pro-inflammatory cytokine interleukin-1β (IL-1β) induces the expression ..
  75. doi Differential modulation of clock gene expression in the suprachiasmatic nucleus, liver and heart of aged mice
    Marta Bonaconsa
    Department of Neurological and Movement Sciences, University of Verona, Verona, Italy Electronic address
    Exp Gerontol 55:70-9. 2014
    ..genes, or also involve secondary clock loop components, including Rev-erbα and the clock-controlled genes Dbp and Dec1. Using quantitative real-time RT-PCR, we here report a comparative analysis of the circadian expression of ..
  76. doi Basic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal cancer cells
    Hiroko Seino
    Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
    Biomed Res 36:89-96. 2015
    DEC1 [basic helix-loop-helix (BHLH) E40/Stra13/Sharp2] and DEC2 (BHLHE41/Sharp1) are BHLH transcription factors that are associated with the regulation of apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in ..
  77. pmc Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread
    Elisa Giannoni
    Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134, Florence, Italy
    Oncotarget 6:24061-74. 2015
    ..inducible factor-1α (HIF-1α) and the transcriptional repressor Differentially Expressed in Chondrocytes-1 (DEC1)...
  78. pmc Differentially Expressed in Chondrocytes 2 (DEC2) Increases the Expression of IL-1β and Is Abundantly Present in Synovial Membrane in Rheumatoid Arthritis
    Juri Olkkonen
    Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    PLoS ONE 10:e0145279. 2015
    ..Our objective was to investigate the expression of direct clock suppressors DEC1 and DEC2 (BHLHE 40 and 41 proteins) in response to TNFα and investigate their role during inflammation.
  79. ncbi SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation
    M J Rossner
    Zentrum für Molekulare Biologie ZMBH, Universitat Heidelberg, Germany
    Mol Cell Neurosci 10:460-75. 1997
    ..This suggests that neuronal bHLH proteins are also involved in the "adaptive" changes of mature CNS neurons which are coupled to glutamatergic stimulation...
  80. ncbi mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression
    Sameena Azmi
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Biol Chem 278:20098-109. 2003
    ..Hairy/Enhancer of Split subfamily of bHLH factors and exhibits the highest structural and sequence identity with Stra13. We show that mSharp-1 specifically binds to the E box motif (CANNTG) as a homodimer and acts as a potent ..
  81. ncbi Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas
    Mayu Yunokawa
    Department of Translational Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734 8553, Japan
    Oncol Rep 17:871-8. 2007
    ..The expressions of its 5 target genes - DEC1, DEC2, carbonic anhydrase-9 (CA9), vascular endothelial growth factor (VEGF), and solute carrier family 2, member 1 ..
  82. ncbi Core-shell InGaAs/GaAs quantum well nanoneedles grown on silicon with silicon-transparent emission
    Michael Moewe
    Department of Electrical Engineering, University of California at Berkeley, Berkeley, California 94720, USA
    Opt Express 17:7831-6. 2009
    ..The nanoneedles assume a 6 degrees - 9 degrees tapered shape, have sharp 2-5 nm tips, are 4 microm in length and 600 nm wide at the base...
  83. doi Late-gestational systemic hypoxia leads to a similar early gene response in mouse placenta and developing brain
    Regina Trollmann
    Department of Pediatrics, University of Erlangen, Erlangen, Germany
    Am J Physiol Regul Integr Comp Physiol 299:R1489-99. 2010
    ..hypoxia-inducible transcription factor (HIF)-dependent genes and immediate early genes (IEG) (Fos, Jun, Egr1, Bhlhb2), apoptosis-promoting factors (Bnip3, Dusp1, Ier3) that were all upregulated, and genes modulating RNA binding and ..
  84. pmc Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells
    Chunyu Zhang
    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, 37 Convent Dr, Rm 1118B, Bethesda, MD 20892, USA
    Mol Cancer Ther 10:1137-48. 2011
    ..early differential expression were partitioned into three groups; those induced by PIAs only (DUSP1, KLF6, CENTD2, BHLHB2, and PREX1), those commonly induced by PIAs and LY (TRIB1, KLF2, RHOB, and CDKN1A), and those commonly suppressed ..
  85. pmc Regulation of the Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells
    Kazuo Asanoma
    Department of Obstetrics and Gynecology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mol Cell Biol 35:4096-109. 2015
    b>BHLHE40 and BHLHE41 (BHLHE40/41) are basic helix-loop-helix type transcription factors that play key roles in multiple cell behaviors. BHLHE40/41 were recently shown to be involved in an epithelial-to-mesenchymal transition (EMT)...
  86. pmc 5-Aminoimidazole-4-carboxyamide-1-β-D-ribofranoside stimulates the rat enhancer of split- and hairy-related protein-2 gene via atypical protein kinase C lambda
    Yoshiko Komatsu
    Matsumoto University Graduate School of Health Science, 2095 1 Niimura, Matsumoto, Nagano 390 1295, Japan
    J Biochem 159:429-36. 2016
    ..Thus, we conclude that the AICAR-induction of theSHARP-2gene is mediated at transcription level by a PI 3-K/aPKCλ pathway. ..
  87. ncbi Clast5/Stra13 is a negative regulator of B lymphocyte activation
    Mika Seimiya
    Division of Pathology, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba 260 8717, Japan
    Biochem Biophys Res Commun 292:121-7. 2002
    ..Clast5 is identical with Stra13, a recently identified member of the basic helix-loop-helix family of transcription factors...
  88. ncbi Insulin induces the expression of the SHARP-2/Stra13/DEC1 gene via a phosphoinositide 3-kinase pathway
    Kazuya Yamada
    Department of Biochemistry, Fukui Medical University, Japan
    J Biol Chem 278:30719-24. 2003
    ..In addition, nuclear run-on assay revealed that transcription of the rat SHARP-2 gene was induced by insulin. Thus, we conclude that insulin induces the transcription of the rat SHARP-2 gene via a phosphoinositide 3-kinase pathway...
  89. ncbi The rat enhancer of split- and hairy-related protein-2 gene: hepatic expression, genomic structure, and promoter analysis
    Satoko Hirano
    Department of Pediatrics, Fukui Medical University, 910 1193 Fukui, Japan
    Arch Biochem Biophys 422:81-90. 2004
    ..Therefore, other E box-binding transcription factors differing from USF proteins or USF-associated proteins are necessary for transcriptional stimulation of the rat SHARP-2 gene...
  90. ncbi Profiling of genes associated with transcriptional responses in mouse hippocampus after transient forebrain ischemia using high-density oligonucleotide DNA array
    Toshihito Nagata
    Department of Advanced Medicine, Nihon University, School of Medicine, 30 1 Oyaguchikami cho, Itabashi ku, Tokyo 173 8610, Japan
    Brain Res Mol Brain Res 121:1-11. 2004
    ..25 genes demonstrated alterations of expression of several kinds of biological pathways, regulating transcription (Bhlhb2, Jun, c-fos, Egr1, Egr2, Fosb, Junb, Ifrd1, Neurod6), the cell cycle (c-fos, Fosb, Jun, Junb, Dusp1), stress ..
  91. ncbi Rhythmic expression of DEC1 and DEC2 in peripheral tissues: DEC2 is a potent suppressor for hepatic cytochrome P450s opposing DBP
    Mitsuhide Noshiro
    Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Genes Cells 9:317-29. 2004
    ..Molecular clocks consisting of the same components also exist in various peripheral organs. DEC1 and DEC2, basic helix-loop-helix transcription factors, were recently reported to be involved in the central clock ..
  92. pmc Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system
    Hidenori Hamaguchi
    Department of Dental and Medical Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Biochem J 382:43-50. 2004
    ..Transcripts of Dec2, as well as those of its related gene Dec1, exhibit a striking circadian oscillation in the suprachiasmatic nucleus, and Dec2 inhibits transcription from the ..
  93. ncbi The hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and its expression in human tissues and tumours
    Helen Turley
    Cancer Research UK Molecular Oncology Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    J Pathol 203:808-13. 2004
    DEC1, also known as SHARP-2 or Stra13, is an important molecule in embryonic differentiation and has recently been identified to be strongly inducible by hypoxia. Its distribution in normal human tissues and most tumour types is unknown...
  94. ncbi Influence of photoperiodic history on clock genes and the circadian pacemaker in the rat retina
    Nils Rohleder
    Department of Anatomy and Cell Biology, Johannes Gutenbergy University, 55099 Mainz, Germany
    Eur J Neurosci 23:105-11. 2006
    ..For this purpose, the 24-h profiles of nine clock genes (bmal1, clock, per1, per2, per3, dec1, dec2, cry1 and cry 2) and the arylalkylamine N-acetyltransferase gene as an indicator of the circadian pacemaker ..
  95. ncbi Two polyketide synthase-encoding genes are required for biosynthesis of the polyketide virulence factor, T-toxin, by Cochliobolus heterostrophus
    Scott E Baker
    Torrey Mesa Research Institute, Syngenta, 3115 Merryfield Row, San Diego, CA 92121, USA
    Mol Plant Microbe Interact 19:139-49. 2006
    ..or closely related fungus. PKS1, a polyketide synthase (PKS)-encoding gene at Tox1A, and DEC1, a decarboxylase-encoding gene at Tox1B, are necessary for T-toxin production...
  96. doi Cellular senescence in oral cancer and precancer and treatment implications: a review
    Julián Campo-Trapero
    Department of Buccofacial Medicine and Surgery, School of Dentistry, Complutense University of Madrid, Spain
    Acta Oncol 47:1464-74. 2008
    ..This antitumor mechanism is known as cellular senescence and is defined as an emergency defence system for cells on the way to becoming cancerous...
  97. doi Clock gene modulation by TNF-alpha depends on calcium and p38 MAP kinase signaling
    Saskia Petrzilka
    Division of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland
    J Biol Rhythms 24:283-94. 2009
    ..regulators of the molecular clock, Per1 and Per2, Cryptochrome-1 (Cry1), and Differentiated embryo chondrocytes-1 (Dec1)...
  98. doi Deleted in Esophageal Cancer 1(DEC1) is down-regulated and contributes to migration in head and neck squamous cell carcinoma cell lines
    Yasuomi Kunimoto
    Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine, Tottori, Japan
    ORL J Otorhinolaryngol Relat Spec 73:17-23. 2011
    Previous studies have shown that the expression of Deleted in Esophageal Cancer 1 (DEC1) is significantly reduced in esophageal squamous cell carcinoma...
  99. doi Advanced light-entrained activity onsets and restored free-running suprachiasmatic nucleus circadian rhythms in per2/dec mutant mice
    Brid Bode
    Circadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Chronobiol Int 28:737-50. 2011
    ..The basic helix-loop-helix transcription factors DEC1 (BHLHE40) and DEC2 (BHLHE41) can interact with this core TTL, forming an accessory feedback mechanism...
  100. doi Analysis of regulatory mechanisms of an insulin-inducible SHARP-2 gene by (S)-Equol
    Ayumi Haneishi
    Department of Health and Nutritional Science, Faculty of Human Health Science, Matsumoto University, 2095 1 Niimura, Matsumoto, Nagano 390 1295, Japan
    Arch Biochem Biophys 525:32-9. 2012
    ..Thus, we conclude that (S)-Equol is an useful dietary supplement to control type 2 diabetes mellitus...
  101. doi Novel signatures of cancer-associated fibroblasts
    Benedek Bozóky
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 133:286-93. 2013
    ..Twelve new proteins differentially expressed in cancer-associated fibroblasts were identified (DLG1, BHLHE40, ROCK2, RAB31, AZI2, PKM2, ARHGAP31, ARHGAP26, ITCH, EGLN1, RNF19A and PLOD2), four of them can be connected to ..

Research Grants7

  1. Mechanism of p63-Dependent Tumor Suppression
    Xinbin Chen; Fiscal Year: 2012
    ..and transcriptional activity, we identified and characterized two p63 targets: RNPC1, a RNA-binding protein, and Dec1, a basic helix-loop-helix transcription factor...
  2. Xinbin Chen; Fiscal Year: 2015
    ..We also identified several novel p73 targets, including Dec1, a basic helix-loop-helix transcription factor, and RNPC1, a RNA-binding protein...
  3. Laura Shaw; Fiscal Year: 2016
    ..Basic helix-loop-helix family, member e40 (Bhlhe40), is a bHLH transcription factor that is related to the E proteins, and is highly expressed in CD8+ T cells...
  4. Molecular mechanism of ID1 function in advanced breast cancer
    Meiyun Fan; Fiscal Year: 2013
    ..Meta-analysis revealed that the expression of BHLHB2, a bHLH transcription factor and putative target of ID1, is strongly associated with hormone-dependent breast ..
  5. Christine Schwartz; Fiscal Year: 2014
    ..The hypothalamic transcriptome data indicates that expression of one circadian clock gene, DEC1, is elevated during torpor...
  6. Isl1 and Wntbeta-catenin regulation of cardiac progenitor cells
    Chulan Kwon; Fiscal Year: 2010
    ..Among the genes upregulated by p-catenin, I found that Bhlhb2, a transcriptional repressor with a novel role in cardiogenesis, is expressed specifically in the cardiac region...
  7. Molecular basis of differentiation and growth control
    Reshma Taneja; Fiscal Year: 2006
    ..To investigate the role of Stra13 in vivo, we have used a loss-of-function (gene-disruption) approach and generated Stra 13-null mice...