beta1 integrin

Summary

Gene Symbol: beta1 integrin
Description: integrin subunit beta 1
Alias: CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, integrin beta-1, glycoprotein IIa, integrin VLA-4 beta subunit, integrin beta 1, integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), very late activation protein, beta polypeptide
Species: human

Top Publications

  1. pmc Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion
    Yasuhito Onodera
    Department of Molecular Biology and 2 Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Cell Biol 197:983-96. 2012
  2. pmc β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation
    Brian T Beaty
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, New York, NY 10461, USA
    Mol Biol Cell 24:1661-75, S1-11. 2013
  3. pmc GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation
    Hira Lal Goel
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA
    EMBO Mol Med 5:488-508. 2013
  4. pmc Cdc42 promotes transendothelial migration of cancer cells through β1 integrin
    Nicolas Reymond
    Randall Division of Cell and Molecular Biophysics, King s College London, London SE1 1UL, England, UK
    J Cell Biol 199:653-68. 2012
  5. pmc Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells
    Dong Wan Seo
    Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 1500, USA
    J Biol Chem 281:3711-21. 2006
  6. doi Stromal cell-derived factor-1/CXC receptor 4 and β1 integrin interaction regulates urokinase-type plasminogen activator expression in human colorectal cancer cells
    Wen Shih Huang
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taiwan
    J Cell Physiol 227:1114-22. 2012
  7. pmc Tetraspanin CD151 stimulates adhesion-dependent activation of Ras, Rac, and Cdc42 by facilitating molecular association between β1 integrins and small GTPases
    In Kee Hong
    Medical and Bio material Research Center, School of Medicine, Kangwon National University, Chunchon, Kangwon Do 200 701, Korea
    J Biol Chem 287:32027-39. 2012
  8. pmc Annexin A2 regulates β1 integrin internalization and intestinal epithelial cell migration
    Carl R Rankin
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology and Mucosal Inflammation Research Unit, Emory University, Atlanta, Georgia 30306, USA
    J Biol Chem 288:15229-39. 2013
  9. pmc Integrin α3β1 controls mRNA splicing that determines Cox-2 mRNA stability in breast cancer cells
    Sita Subbaram
    Center for Cell Biology and Cancer Research, Albany Medical College, MC 165, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Cell Sci 127:1179-89. 2014
  10. pmc Genome-wide screening identified that miR-134 acts as a metastasis suppressor by targeting integrin β1 in hepatocellular carcinoma
    Ruopeng Zha
    Shanghai Medical College, Fudan University, Shanghai, China State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 9:e87665. 2014

Research Grants

  1. PROGNOSTIC IMPLICATION--INNATE IMMUNITY IN HIV INFECTION
    ROGER ROSSEN; Fiscal Year: 2002
  2. William M Nauseef; Fiscal Year: 2016
  3. ETIOLOGY OF STROKE IN CHILDREN WITH SICKLE CELL DISEASE
    Sherri Zimmerman; Fiscal Year: 2004
  4. MOLECULAR BASIS OF PLATELET FUNCTION
    Thomas Kunicki; Fiscal Year: 1992
  5. FUNCTIONAL SIGNIFICANCE OF T CELL ACTIVATION MARKERS
    Albert Donnenberg; Fiscal Year: 1999
  6. IMMUNOREGULATORY CIRCUITS IN MAN
    Chikao Morimoto; Fiscal Year: 2002
  7. SOFTWARE TOOLKIT FOR BASIC & APPLIED VISION RESEARCH
    Lawrence Boyd; Fiscal Year: 2001
  8. Interactions of CD147 Involved in MMP Induction
    MARTIN HEMLER; Fiscal Year: 2008
  9. EBV BMRF-2 Protein in Infection of Oral Epithelial Cells
    Sharof Tugizov; Fiscal Year: 2007
  10. NEURAL CIRCUITRY OF THE KIDNEY
    Mark Weiss; Fiscal Year: 2006

Detail Information

Publications348 found, 100 shown here

  1. pmc Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion
    Yasuhito Onodera
    Department of Molecular Biology and 2 Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Cell Biol 197:983-96. 2012
    ..Our results suggest a novel mechanism by which EGFR signaling promotes the invasiveness of some breast cancer cells via integrin recycling...
  2. pmc β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation
    Brian T Beaty
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, New York, NY 10461, USA
    Mol Biol Cell 24:1661-75, S1-11. 2013
    ..These results describe a fundamental role for β1 integrin in controlling actin polymerization-dependent invadopodial maturation and matrix degradation in metastatic tumor cells...
  3. pmc GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation
    Hira Lal Goel
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA
    EMBO Mol Med 5:488-508. 2013
    ..They also support the feasibility of NRP2-based therapy for the treatment of TNBC that targets and impedes the function of TICs...
  4. pmc Cdc42 promotes transendothelial migration of cancer cells through β1 integrin
    Nicolas Reymond
    Randall Division of Cell and Molecular Biophysics, King s College London, London SE1 1UL, England, UK
    J Cell Biol 199:653-68. 2012
    ..By identifying β1 integrin as a transcriptional target of Cdc42, our results provide new insight into Cdc42 function...
  5. pmc Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells
    Dong Wan Seo
    Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 1500, USA
    J Biol Chem 281:3711-21. 2006
    ....
  6. doi Stromal cell-derived factor-1/CXC receptor 4 and β1 integrin interaction regulates urokinase-type plasminogen activator expression in human colorectal cancer cells
    Wen Shih Huang
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taiwan
    J Cell Physiol 227:1114-22. 2012
    ..In summary, our findings elucidate the mechanisms of SDF-1/CXCR4 downstream signaling and provide insights into the function of SDF-1 in colon cancer cells...
  7. pmc Tetraspanin CD151 stimulates adhesion-dependent activation of Ras, Rac, and Cdc42 by facilitating molecular association between β1 integrins and small GTPases
    In Kee Hong
    Medical and Bio material Research Center, School of Medicine, Kangwon National University, Chunchon, Kangwon Do 200 701, Korea
    J Biol Chem 287:32027-39. 2012
    ....
  8. pmc Annexin A2 regulates β1 integrin internalization and intestinal epithelial cell migration
    Carl R Rankin
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology and Mucosal Inflammation Research Unit, Emory University, Atlanta, Georgia 30306, USA
    J Biol Chem 288:15229-39. 2013
    ..These findings support an important role of AnxA2 in controlling dynamics of β1 integrin at the cell surface that in turn is required for the active turnover of cell-matrix associations, cell migration, and wound closure...
  9. pmc Integrin α3β1 controls mRNA splicing that determines Cox-2 mRNA stability in breast cancer cells
    Sita Subbaram
    Center for Cell Biology and Cancer Research, Albany Medical College, MC 165, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Cell Sci 127:1179-89. 2014
    ..Our study identifies α3β1-mediated AEU as a novel paradigm of integrin-dependent gene regulation that has potential for exploitation as a therapeutic target...
  10. pmc Genome-wide screening identified that miR-134 acts as a metastasis suppressor by targeting integrin β1 in hepatocellular carcinoma
    Ruopeng Zha
    Shanghai Medical College, Fudan University, Shanghai, China State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 9:e87665. 2014
    ..revealed that miR-134 suppressed the invasion and metastasis of HCC cells in vitro and in vivo, and integrin beta 1 (ITGB1) was a direct and functional target gene of miR-134...
  11. pmc Loss of beta1-integrin enhances TGF-beta1-induced collagen expression in epithelial cells via increased alphavbeta3-integrin and Rac1 activity
    Tomoko Hayashida
    Division of Kidney Diseases, Department of Pediatrics, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 285:30741-51. 2010
    ..Together, our results indicate that decreasing β1 chain causes αvβ3-integrin to become functionally dominant and promotes renal cell fibrogenesis via Rac1-mediated ERK activity...
  12. ncbi cDNA cloning and chromosomal localization of human alpha(11) integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues
    T Velling
    Department of Cell and Molecular Biology, BMC, Box 596, Uppsala University, S 751 24 Uppsala, Sweden
    J Biol Chem 274:25735-42. 1999
    ..Future studies will reveal the importance of alpha(11)beta(1) for muscle development and integrity in adult muscle and other tissues...
  13. ncbi High affinity interaction of integrin alpha4beta1 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) enhances migration of human melanoma cells across activated endothelial cell layers
    Martin Klemke
    Institute for Immunology, University of Heidelberg, Heidelberg, Germany
    J Cell Physiol 212:368-74. 2007
    ..These data imply that only high affinity interactions between the integrin alpha4beta1 on melanoma cells and VCAM-1 on activated endothelial cells may enhance the metastatic capacity of human beta2/beta3-negative melanoma cells...
  14. pmc Mesenchymal stem cell migration is regulated by fibronectin through α5β1-integrin-mediated activation of PDGFR-β and potentiation of growth factor signals
    Jennifer Veevers-Lowe
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    J Cell Sci 124:1288-300. 2011
    ..This synergistic relationship between α5β1-integrin and PDGFR-β is a fundamental determinant of cell migration. Thus, fibronectin-rich matrices can prime PDGFR-β to recruit mesenchymal cells at sites of vascular remodelling...
  15. doi Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions
    Olivier Rossier
    Interdisciplinary Institute for Neuroscience, University of Bordeaux, UMR 5297, F 33000 Bordeaux, France
    Nat Cell Biol 14:1057-67. 2012
    ..Thus, differential transmission of actin motion to fibronectin occurs through specific integrins within FAs...
  16. ncbi A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5
    D D Hu
    Cancer Research Center, La Jolla Cancer Research Foundation, California 92037, USA
    J Biol Chem 270:26232-8. 1995
    ..Collectively, these findings prove that integrins alpha v beta 1, alpha v beta 3, and alpha v beta 5 have similar affinity for OPN. Therefore, all three integrins must be considered when evaluating the biological affects of OPN...
  17. ncbi The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor
    G Barillari
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    Blood 94:663-72. 1999
    ..This soluble bFGF mediates Tat-induced vascular cell growth. These effects resemble those of extracellular matrix proteins, suggesting that Tat enhances angiogenesis and promotes KS progression by a molecular mimicry of these molecules...
  18. ncbi CD9 is expressed on human endometrial epithelial cells in association with integrins alpha(6), alpha(3) and beta(1)
    K R Park
    Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Mol Hum Reprod 6:252-7. 2000
    ..These results also suggest that CD9 may be an important regulator of these integrins in the human endometrium...
  19. ncbi CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans
    S Lozahic
    INSERM U268, Hopital Paul Brousse, Villejuif, France
    Eur J Immunol 30:900-7. 2000
    ..CD46 associated in part with several tetranspans and with all beta1 integrins that were tested (CD29/CD49a, CD29/CD49b, CD29/CD49c, CD29/CD49e, CD29/CD49f) but not with beta4 integrins...
  20. pmc Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling
    David A Calderwood
    Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:2272-7. 2003
    ..These data establish that short integrin beta tails interact with a large number of PTB domain-containing proteins through a structurally conserved mechanism...
  21. doi Homeobox D1 regulates angiogenic functions of endothelial cells via integrin β1 expression
    Hyojin Park
    College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea
    Biochem Biophys Res Commun 408:186-92. 2011
    ..Furthermore, we identified the putative HOXD1-binding sites in the promoter region of ITGB1. Together, these findings suggest that HOXD1 plays a significant role in EC functions by regulating the expression of ITGB1...
  22. pmc Extracellular membrane-proximal domain of HAb18G/CD147 binds to metal ion-dependent adhesion site (MIDAS) motif of integrin β1 to modulate malignant properties of hepatoma cells
    Yong Li
    Cell Engineering Research Centre and Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi an 710032, China
    J Biol Chem 287:4759-72. 2012
    ....
  23. pmc Fibronectin induces endothelial cell migration through β1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766
    Li Zou
    Gastroenterology Research Unit and Cancer Cell Biology Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 287:7190-202. 2012
    ....
  24. doi The efficacy evaluation of cryosurgery in pancreatic cancer patients with the expression of CD44v6, integrin-β1, CA199, and CEA
    Gang Zhou
    Department of Oncology, The GIBH Affiliated Fuda Hospital, Chinese Academy of Sciences, Chigang, Guangzhou 510305, China
    Mol Biotechnol 52:59-67. 2012
    ..05). The higher expression of CD44v6, integrin-β1, CA199, and CEA are closely related to the progression and metastasis of pancreatic cancer and may play a important role in the curative evaluation of cryosurgery of pancreatic cancer...
  25. doi Endothelial cell surface expression of protein disulfide isomerase activates β1 and β3 integrins and facilitates dengue virus infection
    Shu Wen Wan
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
    J Cell Biochem 113:1681-91. 2012
    ..These findings may have implications for anti-DENV drug design...
  26. pmc Crystal structure of α5β1 integrin ectodomain: atomic details of the fibronectin receptor
    Masamichi Nagae
    Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    J Cell Biol 197:131-40. 2012
    ..The structure also enabled the precise prediction of the acceptor residue for the auxiliary synergy site of fibronectin on the α5 subunit, which was experimentally confirmed by mutagenesis and kinetic binding assays...
  27. doi Periostin activates integrin α5β1 through a PI3K/AKT‑dependent pathway in invasion of cholangiocarcinoma
    Kusumawadee Utispan
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Int J Oncol 41:1110-8. 2012
    ..These data provide evidence that PN-activated invasion of CCA cells is through the ITGα5β1/PI3K/AKT pathway. Strategies aimed to inhibit this pathway may, thus, provide therapeutic benefits...
  28. pmc Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells
    Hongyu Tian
    Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    EMBO J 31:3885-900. 2012
    ..These studies provide a novel mechanism for the regulation of TGF-β superfamily signalling and endothelial function through crosstalk with integrin signalling pathways...
  29. pmc Epidermal growth factor (EGF) regulates α5β1 integrin activation state in human cancer cell lines through the p90RSK-dependent phosphorylation of filamin A
    Daniel Vial
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
    J Biol Chem 287:40371-80. 2012
    ..Regulation of integrin activation has important implications for tumor cell invasion and metastasis...
  30. pmc Epigenetic regulation of galectin-3 expression by β1 integrins promotes cell adhesion and migration
    Coert Margadant
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 287:44684-93. 2012
    ..In conclusion, we identify a functional feedback-loop between β1 integrins and Gal-3 that involves the epigenetic induction of Gal-3 expression during integrin-induced EMT and cell scattering...
  31. pmc Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1
    Masaaki Fujita
    Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA 95817, USA
    J Immunol 189:5809-19. 2012
    ..These findings suggest that K36E/R37E acts as a dominant-negative CX3CR1 antagonist and that FKN-CD/integrin interaction is a novel therapeutic target in inflammatory diseases...
  32. pmc The plasma membrane sialidase NEU3 regulates the malignancy of renal carcinoma cells by controlling β1 integrin internalization and recycling
    Cristina Tringali
    Department of Medical Biotechnology, University of Milan, Segrate, 20090 Milan, Italy
    J Biol Chem 287:42835-45. 2012
    ..Therefore, our data identify NEU3 as a key regulator of the β1 integrin-recycling pathway and FAK/AKT signaling and demonstrate its crucial role in RCC malignancy...
  33. pmc Integrin alpha2beta 1 (α2β1) promotes prostate cancer skeletal metastasis
    Joseph L Sottnik
    Department of Urology, The University of Michigan, Ann Arbor, MI 48109, USA
    Clin Exp Metastasis 30:569-78. 2013
    ..Taken together, these data support that α2β1 integrin is needed for the efficient metastasis of PCa cells to the skeleton...
  34. pmc Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation
    Huifang Xu
    National Heart and Lung Institute, Imperial College London, London, United Kingdom
    PLoS ONE 7:e52209. 2012
    ..Our data thus demonstrate an adhesion-promoting role of the DDRs, whereby overexpression and/or activation of the DDRs leads to enhanced integrin-mediated cell adhesion as a result of higher integrin activation state...
  35. doi Syndecan-1 modulates β-integrin-dependent and interleukin-6-dependent functions in breast cancer cell adhesion, migration, and resistance to irradiation
    Hebatallah Hassan
    Department of Gynecology and Obstetrics, University Hospital Munster, Germany
    FEBS J 280:2216-27. 2013
    ..Syndecan-1 deficiency also attenuates the modulatory effect of the inflammatory microenvironment constituent interleukin-6 on cancer cell migration...
  36. pmc NF-κB regulates radioresistance mediated by β1-integrin in three-dimensional culture of breast cancer cells
    Kazi Mokim Ahmed
    Department of Cancer and DNA Damage Responses, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley
    Cancer Res 73:3737-48. 2013
    ..As β1-integrin also activates NF-κB, our findings reveal a novel forward feedback pathway that could be targeted to enhance therapy...
  37. pmc BB0172, a Borrelia burgdorferi outer membrane protein that binds integrin α3β1
    Elaine Wood
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas, USA
    J Bacteriol 195:3320-30. 2013
    ..This is the first report of a borrelial adhesin with a metal ion-dependent adhesion site (MIDAS) motif that is similar to those observed in eukaryotic integrins and has a similar function. ..
  38. pmc Expression of CD44v6 and integrin-β1 for the prognosis evaluation of pancreatic cancer patients after cryosurgery
    Gang Zhou
    Department of Oncology, The GIBH Affiliated Fuda Hospital, Chinese Academy of Sciences, Guangzhou 510305, China
    Diagn Pathol 8:146. 2013
    ..Many previous studies demonstrated that cell adhesion molecules CD44v6 and integrin-β1 had been extensively investigated as potential prognostic markers of various cancers. However, data in PC are scarce...
  39. pmc ß1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion
    Ester Antelmi
    Department of Bioscience, Biotechnology and Biopharmacologics, University of Bari, Bari, Italy Department of Pathology, Anatomic Pathology A Unit, Istituto Nazionale Tumori, Milan, Italy
    PLoS ONE 8:e75113. 2013
    ....
  40. pmc Matrix metalloproteinase-2 cleavage of the β1 integrin ectodomain facilitates colon cancer cell motility
    Jakub Kryczka
    Department of Molecular and Medical Biophysics, Medical University of Lodz, 92 215 Lodz, Poland
    J Biol Chem 287:36556-66. 2012
    ....
  41. pmc Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis
    Hui Wang
    Dept of Pathology, Rm 916D ARC, Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    J Cell Biol 164:935-41. 2004
    ..The early arrest of tumor cells in the pulmonary vasculature through interaction of alpha3beta1 integrin with LN-5 in exposed BM provides both a molecular and a structural basis for cell arrest during pulmonary metastasis...
  42. ncbi Extracellular matrix regulates endothelial functions through interaction of VEGFR-3 and integrin alpha5beta1
    Xuefeng Zhang
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Physiol 202:205-14. 2005
    ..Our results indicate that integrin alpha5beta1 participates in the activation of both VEGFR-3 and its downstream PI3 kinase/Akt signaling pathway, which is essential for FN-mediated lymphatic endothelial cell survival and proliferation...
  43. pmc Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli
    Danelle S Eto
    Division of Cell Biology and Immunology, Pathology Department, University of Utah, Salt Lake City, Utah, United States of America
    PLoS Pathog 3:e100. 2007
    ..of host bladder cells is inhibited by beta1 and alpha3 integrin-specific antibodies and by disruption of the beta1 integrin gene in the GD25 fibroblast cell line...
  44. pmc Interendothelial claudin-5 expression depends on cerebral endothelial cell-matrix adhesion by β(1)-integrins
    Takashi Osada
    Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    J Cereb Blood Flow Metab 31:1972-85. 2011
    ..Hence, endothelial cell-matrix interactions via β(1)-integrin directly affect interendothelial cell tight junction claudin-5 expression and brain microvascular permeability...
  45. pmc Netrin-4 activates endothelial integrin {alpha}6{beta}1
    Frederic Larrieu-Lahargue
    University of Utah, Eccles Institute of Human Genetics, Salt Lake City, UT 84112, USA
    Circ Res 109:770-4. 2011
    ..Netrin family members were shown to signal through a range of receptors, including integrins (such as α3β1, α6β1, and α6β4) in nonendothelial cells...
  46. doi The ins and outs of HIV-1 Tat
    Solène Debaisieux
    CPBS, UMR 5236 CNRS, Universite de Montpellier, 1919 Route de Mende, 34923, Montpellier Cedex 05, France
    Traffic 13:355-63. 2012
    ..This review focuses on some of the recently identified molecular details underlying the unusual transcellular transport pathway used by Tat, such as the role of the single Trp in Tat for its membrane insertion and translocation...
  47. pmc Slit2/Robo4 signaling modulates HIV-1 gp120-induced lymphatic hyperpermeability
    Xuefeng Zhang
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 8:e1002461. 2012
    ..Our results indicate that targeting Slit2/Robo4 signaling may protect the integrity of the lymphatic barrier and limit the dissemination of HIV in the host...
  48. pmc HIV-1 tat promotes integrin-mediated HIV transmission to dendritic cells by binding Env spikes and competes neutralization by anti-HIV antibodies
    Paolo Monini
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 7:e48781. 2012
    ..As Tat also binds Envs from different clades, new vaccine strategies should exploit the Tat/Env interaction for both preventative and therapeutic interventions...
  49. ncbi Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor
    A Weinacker
    Lung Biology Center, University of California, San Francisco 94143
    J Biol Chem 269:6940-8. 1994
    ..In such cells, fibronectin binding ability could be blocked by an antibody to alpha v integrins. These results constitute the first direct evidence that alpha v beta 6 mediates cell attachment to fibronectin...
  50. ncbi Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase
    G E Hannigan
    Cancer Biology Research Program, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada
    Nature 379:91-6. 1996
    ..We propose that ILK is a receptor-proximal protein kinase regulating integrin-mediated signal transduction...
  51. doi The interaction between β1 integrins and ERK1/2 in osteogenic differentiation of human mesenchymal stem cells under fluid shear stress modelled by a perfusion system
    Liyue Liu
    Institute of Cell Biology, College of Life Sciences, Zhejiang University, Hangzhou, 310058, People s Republic of China Departmant of biology, Ningde Normal University, Ningde, Fujian, 352101, People s Republic of China
    J Tissue Eng Regen Med 8:85-96. 2014
    ....
  52. ncbi Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on beta1 integrins and the cytoskeleton
    Vira V Artym
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Carcinogenesis 23:1593-601. 2002
    ..Based on these findings, we speculate that formation of heterogeneous lytic domains in the invading membranes of LOX cells increases the efficiency of directed pericellular proteolysis...
  53. ncbi JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells
    Christel Moog-Lutz
    Hopital Robert Debre, Institut National de la Sante et de la Recherche Medicale, Unité U417, 48 Boulevard Serurier, 75019 Paris, France
    Blood 102:3371-8. 2003
    ..Altogether, our results point to JAML as a novel member of the JAM family expressed on leukocytes with a possible role in leukocyte transmigration...
  54. doi α3β1 integrins regulate CD151 complex assembly and membrane dynamics in carcinoma cells within 3D environments
    T M E Scales
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunts House, Guys Campus, London, UK
    Oncogene 32:3965-79. 2013
    ..These novel findings shed light on the complex crosstalk and switching between receptor complexes in response to different extracellular cues during cell invasion in 3D environments...
  55. ncbi The alpha(2)beta(1) and alpha(3)beta(1) integrins do not mediate attachment of endometrial cells to peritoneal mesothelium
    Craig A Witz
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, Texas, San Antonio 78229 3900, USA
    Fertil Steril 78:796-803. 2002
    ..To evaluate the possible role of mesothelial alpha(2)beta(1) and alpha(3)beta(1) integrins in the attachment of endometrial stromal cells (ESCs) and endometrial epithelial cells (EECs)...
  56. pmc Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation
    Henri Noël Fournier
    Laboratoire d Etude de la Différenciation et de l Adhérence Cellulaires, Unité Mixte Recherche Université Joseph Fourier Centre National de la Recherche Scientifique 5538 Institut Albert Bonniot, Faculte de Medecine de Grenoble, La Tronche Cedex, France
    Mol Biol Cell 16:1859-71. 2005
    Integrin cytoplasmic domain-associated protein 1 (ICAP-1) has been shown to interact specifically with the beta1 integrin cytoplasmic domain and to control cell spreading on fibronectin...
  57. ncbi Association of human platelet alloantigen 1 through 5 polymorphisms with ischemic stroke
    Sarra Saidi
    Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia
    Cerebrovasc Dis 25:81-6. 2008
    ..This is the first evidence demonstrating differential association of the common 5 HPA gene variants with stroke, with HPA-1b and HPA-5b representing strong genetic risk factors...
  58. pmc miRNA-29c suppresses lung cancer cell adhesion to extracellular matrix and metastasis by targeting integrin β1 and matrix metalloproteinase2 (MMP2)
    Heyong Wang
    The Central Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
    PLoS ONE 8:e70192. 2013
    ..The results show that miR-29c may be a novel therapeutic candidate target to slow lung cancer metastasis. ..
  59. ncbi Beta1 integrin/focal adhesion kinase-mediated signaling induces intercellular adhesion molecule 1 and receptor activator of nuclear factor kappaB ligand on osteoblasts and osteoclast maturation
    Shingo Nakayamada
    First and Second Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu, 807 8555, Japan
    J Biol Chem 278:45368-74. 2003
    We have assessed characteristics of primary human osteoblasts, shedding light on signaling mediated by beta1 integrin. beta1 integrins are major receptors for these matrix glycoproteins...
  60. doi β-1,4-Galactosyltransferase III enhances invasive phenotypes via β1-integrin and predicts poor prognosis in neuroblastoma
    Hsiu Hao Chang
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, New Taipei City, Taiwan
    Clin Cancer Res 19:1705-16. 2013
    ..We therefore investigated the expression and role of B4GALT3 in NB...
  61. pmc Trop-2 promotes prostate cancer metastasis by modulating β(1) integrin functions
    Marco Trerotola
    Prostate Cancer Discovery and Development Program, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cancer Res 73:3155-67. 2013
    ..In conclusion, we provide the first evidence that β(1) integrin-dependent migratory and metastatic competence of prostate cancer cells is enhanced by Trop-2...
  62. pmc {beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation
    Paola Defilippi
    Department of Genetics, Biology and Biochemistry, University of Torino, 10126, Torino, Italy
    J Cell Biol 168:1099-108. 2005
    ..Here, we show that in endothelial cells the active beta1 integrin constitutively associates with the unphosphorylated IL-3 receptor (IL-3R) beta common subunit...
  63. ncbi Protective effect of hyaluronic acid on interleukin-1-induced deregulation of beta1-integrin and insulin-like growth factor-I receptor signaling and collagen biosynthesis in cultured human chondrocytes
    Ewa Karna
    Department of Medicinal Chemistry, Medical University in Białystok, Kilinskiego 1, 15 089 Bialystok, Poland
    Mol Cell Biochem 308:57-64. 2008
    ..We propose that IGF-I receptor and beta1-integrin signaling may play an important role in protective effect of hyaluronic acid on interleukin-1-induced inhibition of collagen biosynthesis in cultured human chondrocytes...
  64. ncbi Regulation of urokinase receptor function and pericellular proteolysis by the integrin alpha(5)beta(1)
    Rosemary Bass
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    Thromb Haemost 101:954-62. 2009
    ..These interactions may be modified by other integrins, suggesting a complex interplay between uPAR and integrins on the cell surface with the potential to regulate invasive cell migration...
  65. doi H. pylori cagL amino acid sequence polymorphism Y58E59 induces a corpus shift of gastric integrin α5β1 related with gastric carcinogenesis
    Yi Chun Yeh
    Department of Internal Medicine, National Cheng Kung University Medical Center, Tainan, Taiwan
    Mol Carcinog 50:751-9. 2011
    ..05). H. pylori CagL amino acid polymorphisms like Y58E59 correlate with a higher risk of GCA, and may regulate a corpus shift of gastric integrin α5β1 to lead to severe corpus gastritis during gastric carcinogenesis...
  66. pmc Endothelial expression of TNF receptor-1 generates a proapoptotic signal inhibited by integrin α6β1 in glioblastoma
    Ping Huang
    Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA
    Cancer Res 72:1428-37. 2012
    ..Together, our findings indicate that the laminin receptor integrin α6β1 promotes the survival of brain ECs by inhibiting prodeath signaling by TNF-R1, in part by inducing cFLIP expression...
  67. doi Expression of putative stem cell genes Musashi-1 and beta1-integrin in human colorectal adenomas and adenocarcinomas
    Li Fang Fan
    Department of Pathology, Wuhan University, China
    Int J Colorectal Dis 25:17-23. 2010
    ..This study was to detect expressions of the two genes in colorectal adenomas and carcinomas and to analyze the correlation between Musashi-1 and beta1-integrin...
  68. doi RGS10 restricts upregulation by chemokines of T cell adhesion mediated by α4β1 and αLβ2 integrins
    David García-Bernal
    Departamento de Medicina Celular y Molecular, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, 28040 Madrid, Spain
    J Immunol 187:1264-72. 2011
    ..These results identify RGS10 as a key molecule that contributes to the termination of Gα-dependent signaling during chemokine-activated α4β1- and αLβ2-dependent T cell adhesion...
  69. doi Prognostic role of integrin β1, E-cadherin, and rac1 expression in small cell lung cancer
    Myung Hee Chang
    Division of Oncology, Department of Medicine, Seoul St Mary s Hospital, Catholic University School of Medicine, Korea
    APMIS 120:28-38. 2012
    ..024), overall response rate (p < 0.001), and less than two metastasis (p = 0.003) were prognostic factors for longer PFS. These results suggest that ECAD expression may be useful as a prognostic indicator in patients with SCLC...
  70. pmc TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells
    K Mythreye
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Oncogene 32:1416-27. 2013
    ....
  71. pmc Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human β1 and α2 integrin
    Nicklas Heine Staunstrup
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    PLoS ONE 7:e36658. 2012
    ....
  72. doi MARVELD1 regulates integrin β1-mediated cell adhesion and actin organization via inhibiting its pre-mRNA processing
    Shan Wang
    School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China
    Int J Biochem Cell Biol 45:2679-87. 2013
    ..These studies provide a novel regulatory mechanism of cell-ECM adhesion by nuclear protein in cells. ..
  73. pmc Bone marrow-derived mesenchymal stem cells enhance angiogenesis via their α6β1 integrin receptor
    Bita Carrion
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, United States
    Exp Cell Res 319:2964-76. 2013
    ..This conclusion may have important implications in the optimization of cell-based strategies to promote angiogenesis...
  74. ncbi Tetraspanin CD9 is associated with very late-acting integrins in human vascular smooth muscle cells and modulates collagen matrix reorganization
    A Scherberich
    Laboratoire de Pharmacologie et Physiologie Cellulaires, Faculte de Pharmacie, Illkirch France
    Arterioscler Thromb Vasc Biol 18:1691-7. 1998
    ..We studied the changes in expression of CD9 and beta1-integrins (CD29, VLA) in human vascular smooth muscle cells (VSMCs) under in vitro culture conditions mimicking proliferative ..
  75. ncbi Association of polymorphisms of platelet membrane integrins alpha IIb(beta)3 (HPA-1b/Pl) and alpha2(beta)1 (alpha807TT) with premature myocardial infarction
    R B Zotz
    Department of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Dusseldorf, Germany
    J Thromb Haemost 3:1522-9. 2005
    ..This association requires confirmation in follow-up studies...
  76. doi Lipid raft regulates the initial spreading of melanoma A375 cells by modulating β1 integrin clustering
    Ruifei Wang
    Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China
    Int J Biochem Cell Biol 45:1679-89. 2013
    ..We also showed that lipid raft disruption impaired A375 cell migration in both transwell and wound healing models. Together, these findings provide a new insight for the relationship between lipid raft and the regulation of integrins. ..
  77. pmc Tetraspanins CD81 and CD82 facilitate α4β1-mediated adhesion of human erythroblasts to vascular cell adhesion molecule-1
    Frances A Spring
    Bristol Institute for Transfusion Sciences, Bristol, United Kingdom
    PLoS ONE 8:e62654. 2013
    ..These results strongly suggest that tetraspanins have a functional role in terminal erythropoiesis by modulating interactions of erythroblast α4β1 with both macrophages and extracellular matrix...
  78. doi Novel focal adhesion protein kindlin-2 promotes the invasion of gastric cancer cells through phosphorylation of integrin β1 and β3
    Zhanlong Shen
    Department of Gastroenterological Surgery, Peking University People s Hospital, Beijing, PR China
    J Surg Oncol 108:106-12. 2013
    ..However, the mechanism by which kindlin-2 acts in gastric cancer warrants further evaluation...
  79. pmc CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions
    Veronica Azcutia
    Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115 Harvard Medical School, Boston, MA 02115 Department of Biochemistry and Molecular Biophysics, Washington University, St Louis, MO 63130 Instituto de Cardiologia do Rio Grande do Sul, Fundação Universitária de Cardiologia, Porto Alegre 90010 395, Brazil Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115 Division of Gastrointestinal Pathology, Emory University School of Medicine, Atlanta, GA 30322 Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114
    Mol Biol Cell 24:3358-68. 2013
    ....
  80. pmc Autophagy modulates cell migration and β1 integrin membrane recycling
    Véronique Tuloup-Minguez
    INSERM UMR 984 University of Paris Sud 11 Châtenay Malabry, France
    Cell Cycle 12:3317-28. 2013
    ..From these findings, we conclude that autophagy regulates cell migration, a central mechanism in cell development, angiogenesis, and tumor progression, by mitigating the cell surface expression of β1 integrins. ..
  81. pmc Structure of integrin alpha5beta1 in complex with fibronectin
    Junichi Takagi
    The Center for Blood Research, Department of Pediatrics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    EMBO J 22:4607-15. 2003
    ..This finding is corroborated by kinetic analysis of real-time binding data, which shows that the synergy site greatly enhances k(on) but has little effect on the stability or k(off) of the complex...
  82. ncbi Implication of alpha5beta1 integrin in invasion of drug-resistant MCF-7/ADR breast carcinoma cells: a role for MMP-2 collagenase
    G E Morozevich
    Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, 119121, Russia
    Biochemistry (Mosc) 73:791-6. 2008
    ..These data suggest that alpha5beta1 controls invasion ability of these cells by regulating expression of MMP-2, which involves PI-3K and Erk1/2 protein kinase signaling...
  83. doi αv integrin processing interferes with the cross-talk between αvβ5/β6 and α2β1 integrins
    Céline Defilles
    INSERM, UMR 911, Centre de Recherche en Oncologie et Oncopharmacologie, F 13005 Marseille, France
    Biol Cell 103:519-29. 2011
    ..We previously demonstrated that αvβ5/β6 integrin represses α2β1-dependent cell migration. The αv subunits undergo an endoproteolytic cleavage by protein convertases, whose role in tumoral invasion has remained controversial...
  84. pmc Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with α5β1 integrin in glioma
    D Kesanakurti
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61605, USA
    Oncogene 32:327-40. 2013
    ..Our data indicate the possible role of MMP-2/α5β1 interaction in the regulation of α5β1-mediated IL-6/Stat3 signaling activation and signifies the therapeutic potential of blocking MMP-2/α5β1 interaction in glioma treatment...
  85. ncbi Novel isoform of beta 1 integrin expressed in skeletal and cardiac muscle
    N I Zhidkova
    Department of Cell Biology, University of Alabama at Birmingham 35294, USA
    Biochem Biophys Res Commun 214:279-85. 1995
    ..A beta 1D-specific anti-peptide polyclonal antibody was prepared and immunoprecipitation of tissue extracts with subsequent immunoblotting showed expression of beta 1D isoform only in striated muscle cells...
  86. ncbi Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
    M Jane Arboleda
    Department of Medicine, Division of Hematology and Oncology, University of California Los Angeles, UCLA School of Medicine, Los Angeles, California 90095, USA
    Cancer Res 63:196-206. 2003
    ..Increased invasion by AKT2 was blocked by preincubation with an anti-beta1 integrin function blocking antibody, exposure to wortmannin, and by expression of phosphatase and tensin homologue ..
  87. ncbi Myosin-X provides a motor-based link between integrins and the cytoskeleton
    Hongquan Zhang
    Karolinska Institutet, Department of Laboratory Medicine, Division of Pathology F46, Karolinska University Hospital Huddinge, SE 141 86 Huddinge, Sweden
    Nat Cell Biol 6:523-31. 2004
    ..Taken together, these results indicate that Myo10-mediated relocalization of integrins might serve to form adhesive structures and thereby promote filopodial extension...
  88. ncbi RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251
    Patrick A Kiely
    Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, National University of Ireland, Cork, Ireland
    J Biol Chem 280:7624-33. 2005
    ..In R- cells transiently expressing the Y1250F/Y1251F mutant RACK1 became constitutively associated with beta1 integrin and did not associate with Shc, Src, or Shp2...
  89. pmc Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain
    Ronen Alon
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 171:1073-84. 2005
    ....
  90. ncbi Galectin-1 interacts with beta-1 subunit of integrin
    Elena P Moiseeva
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, UK
    Biochem Biophys Res Commun 310:1010-6. 2003
    ..Direct binding of galectin-1 to beta1 integrin was detected by the immune precipitation of beta1 integrin after chemical cross-linking of 125I-labelled ..
  91. ncbi Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151
    R L Yauch
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 275:9230-8. 2000
    ..Finally, we demonstrated that both NH(2)- and COOH-terminal domains of CD151 are located on the inside of the plasma membrane, thus confirming a long suspected model of TM4SF protein topology...
  92. ncbi Thromboxane A2 receptor agonists antagonize the proangiogenic effects of fibroblast growth factor-2: role of receptor internalization, thrombospondin-1, and alpha(v)beta3
    Anthony W Ashton
    Department of Medicine Cardiology and Molecular Pharmacology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    Circ Res 94:735-42. 2004
    ....
  93. ncbi Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit
    J Liliental
    Department of Medicine, Microbiology and Immunology, University of California at Los Angeles School of Medicine 90095, USA
    J Biol Chem 273:2379-83. 1998
    ..In the yeast two-hybrid assay, WD repeats five to seven of Rack1 (Rack1-WD5/7) interact with integrin beta 1, beta 2, and beta 5 cytoplasmic domain...
  94. ncbi Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction
    D T Loo
    Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
    J Biol Chem 273:23304-12. 1998
    ..intracellular proteins expressed by activated T cells that interact with the cytoplasmic domain of beta1-integrin (CD29), we used the beta1-integrin cytoplasmic domain as bait in the yeast two-hybrid system...
  95. ncbi beta 1 integrin function in vivo: adhesion, migration and more
    C Brakebusch
    Max Planck Institute of Biochemistry, Junior Group Regulation of Cytoskeletal Organization, Martinsried, Germany
    Cancer Metastasis Rev 24:403-11. 2005
  96. ncbi Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells
    L M Schnapp
    Department of Medicine, University of California at San Francisco 94143, USA
    J Cell Sci 108:537-44. 1995
    ..These results suggest that in adult mammalian tissues, alpha 8 is predominantly expressed in smooth muscle and smooth muscle-like contractile cells...
  97. pmc Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle
    E L Palmer
    Lung Biology Center, University of California, San Francisco 94143
    J Cell Biol 123:1289-97. 1993
    ..alpha 9 was detected by immunohistochemistry in airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes...
  98. pmc Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions
    V Serru
    INSERM U268, Hopital Paul Brousse, 94807 Villejuif Cedex, France
    Biochem J 340:103-11. 1999
    ..Because all tetraspan-tetraspan associations are disrupted by digitonin, it is likely that the other tetraspans interact indirectly with integrins, through interactions with CD81 or CD151...
  99. pmc The linkage between beta1 integrin and the actin cytoskeleton is differentially regulated by tyrosine and serine/threonine phosphorylation of beta1 integrin in normal and cancerous human breast cells
    K Takahashi
    Laboratory of Biochemistry, Kanagawa Cancer Center Research Institute 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    BMC Cell Biol 2:23. 2001
    Structural requirements for the beta1 integrin functions in cell adhesion, spreading and signaling have been well documented mainly for fibroblasts...
  100. ncbi Regulation of integrin function by CD47 ligands. Differential effects on alpha vbeta 3 and alpha 4beta1 integrin-mediated adhesion
    Heba O Barazi
    Laboratory of Pathology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:42859-66. 2002
    ..The antibody directly activates a CD47-alpha4beta1 complex, whereas VVM peptides may target an unidentified Gi-linked receptor that regulates alpha4beta1...
  101. ncbi Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A
    Roumen Pankov
    Craniofacial Developmental Biology and Regeneration Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
    J Biol Chem 278:18671-81. 2003
    ..The identification of Trp(775) as a specific site for integrin-mediated Akt signaling supports the concept of specificity of signaling along the integrin cytoplasmic domain...

Research Grants46

  1. PROGNOSTIC IMPLICATION--INNATE IMMUNITY IN HIV INFECTION
    ROGER ROSSEN; Fiscal Year: 2002
    ..These bind to monocyte CD29/CD49e and stimulate cell surface display of proteinase-3, which, in turn, degrades CD49e and other molecules, used ..
  2. William M Nauseef; Fiscal Year: 2016
    ..In addition to PMN, a specific Group IIA phospholipase A2 (GpIIA-PLA2), which is present in plasma of infected animals, tears, and inflammatory fluid, exhibits potent activity to ..
  3. ETIOLOGY OF STROKE IN CHILDREN WITH SICKLE CELL DISEASE
    Sherri Zimmerman; Fiscal Year: 2004
    ..of specific inherited thrombotic mutations, including mutations in the genes for Factor V, Factor VII, MTHFR, GPIIa, prothrombin and fibrinogen, using DNA analysis...
  4. MOLECULAR BASIS OF PLATELET FUNCTION
    Thomas Kunicki; Fiscal Year: 1992
    ..like the fibroblast FR, composed of platelet glycoproteins previously designated GPIc (alpha chain) and GPIIa (beta chain)...
  5. FUNCTIONAL SIGNIFICANCE OF T CELL ACTIVATION MARKERS
    Albert Donnenberg; Fiscal Year: 1999
    ..separation, the field has come to associate markers such as CD45RA and CD62L with immunological naivet, CD45RO and CD29 with memory, and markers such as CD25, CD38 and HLA-DR with activation...
  6. IMMUNOREGULATORY CIRCUITS IN MAN
    Chikao Morimoto; Fiscal Year: 2002
    ..The costimulatory signals can be provided by a number of accessory molecules. Of the costimulatory molecules, CD29/VLA, CD26, and CD27 have been established by this group...
  7. SOFTWARE TOOLKIT FOR BASIC & APPLIED VISION RESEARCH
    Lawrence Boyd; Fiscal Year: 2001
    b>VLAB reinvents the way research software is created through an inexpensive, reusable, nonprogrammer software toolkit with an extensive host program for pooling user created components...
  8. Interactions of CD147 Involved in MMP Induction
    MARTIN HEMLER; Fiscal Year: 2008
    ..abstract_text> ..
  9. EBV BMRF-2 Protein in Infection of Oral Epithelial Cells
    Sharof Tugizov; Fiscal Year: 2007
    ..Our data show that interaction between the EBV BMRF-2 glycoprotein and beta1 integrin play a key role in cell-free virion entry...
  10. NEURAL CIRCUITRY OF THE KIDNEY
    Mark Weiss; Fiscal Year: 2006
    ..abstract_text> ..
  11. Testosterone in TNFR1 Signaling During Acute Myocardial Injury
    Meijing Wang; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  12. MOLECULAR BASIS OF PLATELET ADHESION
    Miguel Cruz; Fiscal Year: 2008
    ..It may also contribute to the development of an effective assay to detect the activity of the metalloprotease in plasma. It will provide molecular guidance for the generation of reagents to treat arterial thrombosis. ..
  13. Role of Eotaxin-3/CCL26 in Allergic Asthma
    Lisa Miller; Fiscal Year: 2008
    ..The identification of chemokines that promote allergic asthma is an important step in the future development of therapeutics to target specific molecules within the airways. [unreadable] [unreadable] [unreadable]..
  14. CELL ADHESION MOLECULES OF MAMMALIAN FERTILIZATION
    Janice Evans; Fiscal Year: 2008
    ..of the interactions of candidate integrins with fertilin beta, including studies of eggs deficient in the beta1 integrin subunit...
  15. Glucocorticoids and Programming of the Hypertensive Vascular Phenotype
    Omid Khorram; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  16. Early Immune Events in Childhood Asthma
    Lisa Miller; Fiscal Year: 2009
    ..abstract_text> ..
  17. BIOLOGICAL PROPERTIES AND REGULATION OF STEM CELLS
    Thalia Papayannopoulou; Fiscal Year: 2009
    ..We believe that the proposed studies will enhance our understanding and provide a more comprehensive picture of the influence of <x4 integrins on prenatal and postnatal hematopoiesis. ..
  18. HPEPT1 IN INTESTINAL INFLAMMATION
    Didier Merlin; Fiscal Year: 2008
    ..The completion of this proposal should molecularly define a link between anL active transport process and intestinal inflammation. ..
  19. Role of Prostaglandins & Phospholipase A in melanocytes
    Glynis Scott; Fiscal Year: 2009
    ..We hypothesize that PG and phospholipases stimulate HM dendricity, MS transfer &pigmentation through different mechanisms that act synergistically to modulate cutaneous pigmentation following UVR. ..
  20. Cognitive Behavioral Stress Management for Chronic Fatigue Syndrome
    Michael Antoni; Fiscal Year: 2009
    ....
  21. CHOC Human Embryonic Stem Cell Culture Training Course
    Philip Schwartz; Fiscal Year: 2008
    ..The courses are held annually in the Spring at the National Human Neural Stem Cell Resource of the Neuroscience Laboratories at the Children's Hospital of Orange County Research Institute. [unreadable] [unreadable] [unreadable]..
  22. Growth Cone Adhesion And Motility
    Karl H Pfenninger; Fiscal Year: 2010
    ..abstract_text> ..
  23. Regulatory function of fyn in oral SCC invasion
    Daniel M Ramos; Fiscal Year: 2010
    ..abstract_text> ..
  24. MECHANISMS OF BIOENGINEERED SKIN IN HUMAN WOUNDS
    Vincent Falanga; Fiscal Year: 2003
    ..The proposed studies will advance our understanding of how a bioengineered skin product works in a human chronic wound and provide insight into further bioengineering needs. ..
  25. Expression and Function of EPLIN
    David Chang; Fiscal Year: 2002
    ..The specific aims of this grant will test our ideas by studying (i) biochemical properties of EPLIN; (ii) function of EPLIN in normal and cancer cells; (iii) function of EPLIN during embryogenesis and in tissue homeostasis. ..
  26. ICAPL AND BETA 1 INTEGRIN SIGNALING
    David Chang; Fiscal Year: 2002
    ..of Icap1alpha to beta1 integrins request the conserved C-terminal Asn-Pro-Lys-Tyr motif and Valine 792 of the beta1 integrin cytoplasmic domain...
  27. GLOBIN SWITCHING AND ERYTHROID DIFFERENTIATION
    Thalia Papayannopoulou; Fiscal Year: 2002
    ....
  28. CONTROL OF SCHWANN CELL DIFFERENTIATION
    Cristina Fernandez Valle; Fiscal Year: 2002
    ....
  29. HIV 1 PROTEINS AND DRUGS OF ABUSE AND METALLOPROTEASES
    Katherine Conant; Fiscal Year: 2003
    ..We will also examine the mechanisms by which these substances may affect MMP production, and identify clinically tolerable compounds which may inhibit such production. ..
  30. Human Endometrial Nitric Oxide: Regulation and Function
    Omid Khorram; Fiscal Year: 2003
    ..This pilot study should shed light on regulation and function of human endometrial NO pathway, an uninvestigated area of research with profound clinical significance. ..
  31. HPEPT1 IN INTESTINAL INFLAMMATION
    Didier Merlin; Fiscal Year: 2003
    ..The project will involve a variety of biochemical methods with emphasis on molecular approaches. The completion of this proposal should molecularly define a link between an active transport process and intestinal inflammation. ..
  32. PATHOGENIC MECHANISMS OF VENOUS DISEASE
    Vincent Falanga; Fiscal Year: 2004
    ..The proposed studies should advance knowledge of the pathogenesis of venous ulceration and fibrosis. ..
  33. ORAL MELANOMA: ALPHA V BETA 3 EXPRESSION AND METASTASIS
    Daniel Ramos; Fiscal Year: 2004
    ..Understanding the role beta3 plays in oral melanoma invasion and metastasis may lead to novel prognostic indicators and development of new treatment strategies. ..
  34. EICOSANOID IN GROWTH CONE REPELLENT SIGNALING
    KARL PFENNINGER; Fiscal Year: 2005
    ..abstract_text> ..
  35. HIV AND EBV INTERACTION IN ORAL MUCOSAL EPITHELIUM
    Sharof Tugizov; Fiscal Year: 2005
    ..The results of these studies will provide new and detailed information on the mechanisms of HIV infection of the oral mucosal epithelium and the role of HIV-EBV infection in oral interepithelial LCs in HIV pathogenesis. ..
  36. CD Expression in Prostate Cancer
    Alvin Liu; Fiscal Year: 2004
    ..CD10 and CD13 are both peptidases and are likely involved in the processing of bioactive signaling peptides. Their absence might lead to the aberrant cellular differentiation and development of cancer. ..
  37. MMPs and Synaptic Injury with HIV/METH
    Katherine Conant; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  38. Thrombin signaling and HIV dementia
    Katherine Conant; Fiscal Year: 2006
    ..abstract_text> ..
  39. EXTRAVASCULAR TRAFFICKING OF HIV+ CELLS AND PROGNOSIS
    Holly Birdsall; Fiscal Year: 2003
    ....
  40. Urologic Epithelial Stem Cells
    Alvin Liu; Fiscal Year: 2004
    ....
  41. FACILITATING POSITIVE ADAPTATION TO BREAST CANCER
    MICHAEL HOWARD ANTONI; Fiscal Year: 2010
    ..abstract_text> ..
  42. SJOGRENS SYNDROME SALIVARY GLAND AND APOPTOSIS
    Howard Dang; Fiscal Year: 2001
    ..Caspase inhibitors will be used to identify specific proteases during apoptosis. Biopsy material from patents with Sjogren's syndrome will be immunostained for bcl-2 family member expression. ..
  43. Tissue Engineering for the Treatment of Delayed Healing
    Vincent Falanga; Fiscal Year: 2007
    ..These studies will advance our understanding of how to reconstitute the wound bed and whether it is possible to correct the abnormal cellular phenotype in non-healing wounds. ..
  44. MMPs in neural networking
    Katherine Conant; Fiscal Year: 2006
    ..The results of our studies should improve our understanding of those CNS inflammatory diseases that are characterized by elevated levels of MMPs. [unreadable] [unreadable] [unreadable]..
  45. MMPS IN HIV DEMENTIA: EFFECTS ON BBB STRUCTURE/FUNCTION
    Katherine Conant; Fiscal Year: 2003
    ..Also, the proposed studies will use both primary brain-derived HIV isolates, which differ from laboratory adapted strains, and normal human cells, which also differ significantly from those of rodent or tumor origin. ..
  46. Mechanisms Modulating Cytoskeletal Dynamics During Schwann Cell Myelination
    CRISTINA MARIA FERNANDEZ VALLE; Fiscal Year: 2010
    ..abstract_text> ..