beta-catenin

Summary

Gene Symbol: beta-catenin
Description: catenin beta 1
Alias: CTNNB, MRD19, armadillo, catenin beta-1, catenin (cadherin-associated protein), beta 1, 88kDa
Species: human

Top Publications

  1. pmc Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
    Yingwei Mao
    Howard Hughes Medical Institute, Cambridge, MA 02139, USA
    Cell 136:1017-31. 2009
  2. ncbi Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    Chunming Liu
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 108:837-47. 2002
  3. ncbi Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    P J Morin
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 275:1787-90. 1997
  4. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996
  5. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
  6. ncbi Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion
    Zhimin Lu
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cancer Cell 4:499-515. 2003
  7. ncbi Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase
    Sebastien Taurin
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Biol Chem 281:9971-6. 2006
  8. pmc Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity
    Dexing Fang
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 282:11221-9. 2007
  9. ncbi P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin
    Liuqing Yang
    Department of Biology, Georgia State University, University Plaza, Atlanta, GA 30303, USA
    Cell 127:139-55. 2006
  10. ncbi Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer
    Ann Mårtensson
    Department of Medical Biosciences, Pathology, Umea University, SE 901 85 Umea, Sweden
    Oncol Rep 17:447-52. 2007

Research Grants

  1. ELIZABETH ANN EKLUND; Fiscal Year: 2016
  2. A Validated Resource of Thyroid Cancer Cell Lines for Pathway Discovery
    JEFFREY ALLEN KNAUF; Fiscal Year: 2010
  3. ELIZABETH ANN EKLUND; Fiscal Year: 2016
  4. SATDARSHAN SINGH MONGA; Fiscal Year: 2016
  5. Tanner J Freeman; Fiscal Year: 2015
  6. MSX2-Wnt Signaling in Cardiovascular Calcification
    Dwight A Towler; Fiscal Year: 2013
  7. Role of Ectodermal Signals in Facial Prominence Outgrowth and Development
    Trevor J Williams; Fiscal Year: 2013
  8. Kenneth W Kinzler; Fiscal Year: 2016
  9. WT1 and beta-catenin targets in Wilms tumor
    Benjamin Tycko; Fiscal Year: 2007
  10. Deciphering Beta-Catenin Contributions in Prostate Cance
    David Mulholland; Fiscal Year: 2008

Detail Information

Publications370 found, 100 shown here

  1. pmc Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
    Yingwei Mao
    Howard Hughes Medical Institute, Cambridge, MA 02139, USA
    Cell 136:1017-31. 2009
    ..Together, these results implicate DISC1 in GSK3beta/beta-catenin signaling pathways and provide a framework for understanding how alterations in this pathway may contribute to the etiology of psychiatric disorders...
  2. ncbi Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    Chunming Liu
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 108:837-47. 2002
    ..Our study uncovers distinct roles and steps of beta-catenin phosphorylation, identifies CKIalpha as a component in Wnt/beta-catenin signaling, and has implications to pathogenesis/therapeutics of human cancers and diabetes...
  3. ncbi Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    P J Morin
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 275:1787-90. 1997
    ..These results indicate that regulation of beta-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or beta-catenin...
  4. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996
    The cytoplasmic proteins beta-catenin of vertebrates and armadillo of Drosophila have two functions: they link the cadherin cell-adhesion molecules to the cytoskeleton, and they participate in the wnt/wingless signal pathway...
  5. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
    ..Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium...
  6. ncbi Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion
    Zhimin Lu
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cancer Cell 4:499-515. 2003
    ..We propose that EGF-induced negative regulation of caveolin-1 plays a central role in the complex cellular changes leading to metastasis...
  7. ncbi Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase
    Sebastien Taurin
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Biol Chem 281:9971-6. 2006
    ..In conclusion, this study identifies a novel, noncanonical mechanism of modulation of beta-catenin signaling through direct phosphorylation of beta-catenin by PKA, promoting its interaction with CREB-binding protein...
  8. pmc Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity
    Dexing Fang
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 282:11221-9. 2007
    ..Phosphorylation of beta-catenin by AKT increases its transcriptional activity and promotes tumor cell invasion, indicating that AKT-dependent regulation of beta-catenin plays a critical role in tumor invasion and development...
  9. ncbi P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin
    Liuqing Yang
    Department of Biology, Georgia State University, University Plaza, Atlanta, GA 30303, USA
    Cell 127:139-55. 2006
    ..These data demonstrated a novel mechanism of phosphor-p68 in mediating the growth factor-induced EMT and uncovered a new pathway to promote beta-catenin nuclear translocation...
  10. ncbi Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer
    Ann Mårtensson
    Department of Medical Biosciences, Pathology, Umea University, SE 901 85 Umea, Sweden
    Oncol Rep 17:447-52. 2007
    ..01). Our results suggest that nuclear accumulation of beta-catenin in CRC is related to CIN and may be of prognostic importance. However, larger studies are needed to verify these findings...
  11. pmc Requirement of cell cycle and apoptosis regulator 1 for target gene activation by Wnt and beta-catenin and for anchorage-independent growth of human colon carcinoma cells
    Chen Yin Ou
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 284:20629-37. 2009
    ....
  12. ncbi Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover
    B R Henderson
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millenium Institute, Westmead NSW 2145, Australia
    Nat Cell Biol 2:653-60. 2000
    ..These findings suggest that wild-type APC controls the nuclear accumulation of beta-catenin by a combination of nuclear export and cytoplasmic degradation...
  13. ncbi Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells
    Jun Yang
    Sealy Center for Cancer Cell Biology and Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Biol Chem 281:17751-7. 2006
    ..The APC domains required for beta-catenin ubiquitination were analyzed. Our results suggest that APC regulates beta-catenin phosphorylation and ubiquitination by distinct domains and by separate molecular mechanisms...
  14. doi Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells
    Katrin Hoffmeyer
    Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
    Science 336:1549-54. 2012
    ..We uncover a previously unknown link between the stem cell and oncogenic potential whereby β-catenin regulates Tert expression, and thereby telomere length, which could be critical in human regenerative therapy and cancer...
  15. ncbi MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis
    Stephan E Baldus
    Institute of Pathology, University of Cologne, Cologne, Germany
    Clin Cancer Res 10:2790-6. 2004
    ..We tried to elucidate the coexpression of both molecules in colorectal cancer to demonstrate possible correlations with clinical, pathological, and prognostic data...
  16. pmc The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling
    Tohru Ishitani
    Department of Molecular Biology, Graduate School of Science, Nagoya University, Chikusa ku, Japan
    Mol Cell Biol 23:131-9. 2003
    ..These results suggest that the TAK1-NLK MAPK cascade is activated by the noncanonical Wnt-5a/Ca(2+) pathway and antagonizes canonical Wnt/beta-catenin signaling...
  17. pmc p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction
    Jose Piedra
    Unitat de Biofisica, Departament de Bioquimica i Biologia Molecular, Facultat de Medicina, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Mol Cell Biol 23:2287-97. 2003
    ....
  18. ncbi Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma
    Soichi Iwai
    Department of Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry, 1 8, Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Cancer Res Clin Oncol 131:773-82. 2005
    ..To clarify the genetic alterations of components of the Wnt pathway in oral squamous cell carcinoma (SCC), we examined mutations in the APC, beta-catenin and Axin genes and subcellular localization of beta-catenin...
  19. pmc Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination
    Shin Ichiro Hino
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Mol Cell Biol 25:9063-72. 2005
    ..These results indicate that PKA inhibits the ubiquitination of beta-catenin by phosphorylating beta-catenin, thereby causing beta-catenin to accumulate and the Wnt signaling pathway to be activated...
  20. pmc Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling
    Hasan Korkaya
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Biol 7:e1000121. 2009
    ....
  21. pmc The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation
    Ilse Timmerman
    Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
    Mol Biol Cell 23:4212-25. 2012
    ....
  22. ncbi CTNNB1 mutations and beta-catenin expression in endometrial carcinomas
    Pilar Machin
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Hum Pathol 33:206-12. 2002
    Mutations in the beta-catenin gene (CTNNB 1) with abnormal nuclear accumulation of beta-catenin have recently been identified in endometrial carcinoma (EC). Their relationship with microsatellite instability (MI) is unclear...
  23. doi Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors
    Sebastien Gaujoux
    Service des Maladies Endocriniennes et Metaboliques, Hopital Cochin, 75014 Paris, France
    J Clin Endocrinol Metab 93:4135-40. 2008
    ..PRKAR1A mutations leading to cAMP pathway dysregulation are observed in primary pigmented nodular adrenocortical diseases (PPNADs) and some sporadic ACAs...
  24. doi Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressive adrenocortical cancers
    Bruno Ragazzon
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, INSERM, U1016, Paris, France
    Cancer Res 70:8276-81. 2010
    ..This study shows the important respective roles of p53 and β-catenin in ACC development, delineating subgroups of ACC with different tumorigenesis and outcomes...
  25. pmc E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
    J Hülsken
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Cell Biol 127:2061-9. 1994
    ..E-cadherin and also with the tumor suppressor gene product APC, and the Drosophila homologue of beta-catenin, armadillo, mediates morphogenetic signals...
  26. ncbi Beta-catenin is involved in insulin-like growth factor 1-mediated transactivation of the androgen receptor
    Meletios Verras
    Department of Urology, R135, Edwards Building, Stanford University School of Medicine, Stanford, California 94305 5328, USA
    Mol Endocrinol 19:391-8. 2005
    ..Moreover, using a pulse-chase experiment, we showed that IGF-I enhances the stability of beta-catenin in prostate cancer cells. Our findings delineate a novel pathway for IGF-I in modulating androgen signaling through beta-catenin...
  27. ncbi Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors
    Hiroaki Yamaoka
    Department of Surgery, Hiroshima University, Hiroshima, Japan
    Oncol Rep 15:551-6. 2006
    ..On the other hand, the expression of cyclin D1, a gene downstream of beta-catenin, might play a role in tumor progression...
  28. pmc Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence
    Gudrun Zulehner
    Department of Internal Medicine I, Centre of Public Health, Medical University of Vienna, Vienna, Austria
    Am J Pathol 176:472-81. 2010
    ..These data suggest that activation of beta-catenin signaling causes dedifferentiation to malignant, immature hepatocyte progenitors and facilitates recurrence of human HCC after orthotopic liver transplantation...
  29. ncbi Crystal structure of a beta-catenin/Tcf complex
    T A Graham
    Department of Biological Structure University of Washington 98195, Seattle, WA, USA
    Cell 103:885-96. 2000
    ..three binding modules that runs antiparallel to beta-catenin along the positively charged groove formed by the armadillo repeats...
  30. pmc Beta-catenin mutations in cell lines established from human colorectal cancers
    M Ilyas
    Cancer Genetics and Immunology Laboratory, Imperial Cancer Research Fund, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 94:10330-4. 1997
    ....
  31. ncbi Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase
    Geng Wu
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 11:1445-56. 2003
    ....
  32. pmc Active beta-catenin signaling is an inhibitory pathway for human immunodeficiency virus replication in peripheral blood mononuclear cells
    Anvita Kumar
    Rush University Medical Center, Department of Immunology Microbiology, 1735 W Harrison Street, 614 Cohn, Chicago, IL 60612, USA
    J Virol 82:2813-20. 2008
    ..Collectively, these data indicate that beta-catenin signaling is an intrinsic molecular pathway restricting HIV replication in PBMCs...
  33. pmc Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin
    Joanne H Heaton
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Am J Pathol 181:1017-33. 2012
    ..Our results are consistent with a model in which dysregulation of one pathway may result in adrenal hyperplasia, but accumulation of a second or multiple alterations is necessary for tumorigenesis...
  34. pmc Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor
    Hans R Widlund
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Dana 630, 44 Binney Street, Boston, MA 02115, USA
    J Cell Biol 158:1079-87. 2002
    ..Thus, beta-catenin regulation of MITF expression represents a tissue-restricted pathway that significantly influences the growth and survival behavior of this notoriously treatment-resistant neoplasm...
  35. ncbi Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia
    Abderrahmane Kaidi
    Cancer Research UK Colorectal Tumour Biology Research Group, Department of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK
    Nat Cell Biol 9:210-7. 2007
    ..This study highlights the importance of the microenvironment in transcriptional regulation...
  36. pmc Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
    Andrey I Khramtsov
    University of Chicago, Department of Medicine, Chicago, IL 60637, USA
    Am J Pathol 176:2911-20. 2010
    ....
  37. ncbi Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential
    U Steinhusen
    Max Delbruck Center for Molecular Medicine, Department of Medical Oncology and Tumorimmunology, Robert Rossle Strasse 10, D 3092, Berlin, Germany
    J Biol Chem 275:16345-53. 2000
    Beta-catenin is a member of the Armadillo repeat protein family with a dual cellular function as a component of both the adherens junction complex and the Wnt/wingless signaling pathway...
  38. ncbi Linking beta-catenin to androgen-signaling pathway
    Fajun Yang
    Department of Surgery and Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5328, USA
    J Biol Chem 277:11336-44. 2002
    ..The ligand binding domain of AR and the NH(2) terminus combined with the first six armadillo repeats of beta-catenin were shown to be necessary for the interaction...
  39. ncbi Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter
    Mohammed Filali
    Department of Anatomy and Cell Biology and the Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 277:33398-410. 2002
    ..In summary, these results provide evidence for transcriptional regulation of the LEF-1 promoter by Wnt and enhance the mechanistic understanding of Wnt/beta-catenin signaling in the regulation of LEF-1-dependent developmental processes...
  40. doi TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis
    Jiong Li
    Laboratory of Molecular Signalling, Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA 90095, USA
    Nat Cell Biol 10:160-9. 2008
    ..Our results unravel two new components required for nuclear beta-catenin function, and have important implications in developing new strategies for inhibiting Wnt-beta-catenin-mediated tumorigenesis...
  41. doi E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    Otto Schmalhofer
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany
    Cancer Metastasis Rev 28:151-66. 2009
    ....
  42. ncbi Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
    M J Hart
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    Curr Biol 8:573-81. 1998
    ..This suggests a possible link between Axin, the Wnt-1 signaling components beta-catenin and glycogen synthase kinase 3 beta (GSK3 beta), and APC...
  43. ncbi The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin
    S Taya
    Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 0101, Japan
    Genes Cells 4:757-67. 1999
    ..These observations prompted us to examine the possible Fam regulation of the stabilization of beta-catenin...
  44. pmc Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction
    Laurence Levy
    Unité d Oncogenèse et Virologie Moléculaire INSERM U579, Institut Pasteur, 75015 Paris, France
    Mol Cell Biol 24:3404-14. 2004
    ..Thus, our results describe a new mechanism by which p300 might regulate beta-catenin transcriptional activity...
  45. ncbi Prognostic and diagnostic significance of beta-catenin nuclear immunostaining in colorectal cancer
    Sze Chuen Cesar Wong
    Biomedical Science, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
    Clin Cancer Res 10:1401-8. 2004
    ..Collectively, the present large-scale study has clearly addressed the clinical significance of beta-catenin nuclear translocation with respect to tumor progression, survival, and differential diagnosis...
  46. pmc A protein knockdown strategy to study the function of beta-catenin in tumorigenesis
    Feng Cong
    Program in Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    BMC Mol Biol 4:10. 2003
    ..Aberrant Wnt signaling, which results from mutations of either beta-catenin or adenomatous polyposis coli (APC), renders beta-catenin resistant to degradation, and has been associated with multiple types of human cancers...
  47. doi The Hippo pathway regulates Wnt/beta-catenin signaling
    Xaralabos Varelas
    Center for Systems Biology, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
    Dev Cell 18:579-91. 2010
    ..These results uncover a cytoplasmic function of TAZ in regulating Wnt signaling and highlight the role of the Hippo pathway in coordinating morphogenetic signaling with growth control...
  48. doi Wnt/beta-catenin signaling in glioma
    Kailiang Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, 300052, People s Republic of China
    J Neuroimmune Pharmacol 7:740-9. 2012
    ..This review reveals new insights into the role of Wnt/beta-catenin signaling in gliomagenesis, and highlights new therapeutic approaches for glioma, based on the modulation of the Wnt/beta-catenin pathway...
  49. doi Role of TAZ as mediator of Wnt signaling
    Luca Azzolin
    Department of Biomedical Sciences, University of Padua School of Medicine, viale Colombo 3, 35126 Padua, Italy
    Cell 151:1443-56. 2012
    ..At the genome-wide level, a substantial portion of Wnt transcriptional responses is mediated by TAZ. TAZ activation is a general feature of Wnt signaling and is functionally relevant to mediate Wnt biological effects...
  50. pmc Nuclear expression of β-catenin promotes RB stability and resistance to TNF-induced apoptosis in colon cancer cells
    Jinbo Han
    Moores UCSD Cancer Center, University of California San Diego, La Jolla, California 92093, USA
    Mol Cancer Res 11:207-18. 2013
    ..Together, these results suggest that nuclear β-catenin-dependent RB stabilization suppresses TNF-induced apoptosis in caspase-8-positive colon cancer cells...
  51. ncbi Beta-catenin affects androgen receptor transcriptional activity and ligand specificity
    C I Truica
    Lombardi Cancer Center, Georgetown University, Washington, DC 20007 2197, USA
    Cancer Res 60:4709-13. 2000
    ..The amount of beta-catenin in complex with AR was increased by androgen. These findings implicate beta-catenin in the regulation of AR function and support a role for beta-catenin mutations in the pathogenesis of prostate cancer...
  52. ncbi Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad
    Hirofumi Mizusaki
    Department of Developmental Biology, National Institute for Basic Biology, Myodaiji cho, Okazaki 444 8585, Japan
    Mol Endocrinol 17:507-19. 2003
    ..We thus conclude that Wnt4 signaling mediates the increased expression of Dax-1 as the ovary becomes sexually differentiated...
  53. ncbi Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein
    Sheri L Holmen
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Biochem Biophys Res Commun 328:533-9. 2005
    ..We found that Dkk1-Fz5, but not Dkk3-Fz5, potently synergized with LRP6 to activate signaling in a dishevelled-dependent manner...
  54. pmc NHERF links the N-cadherin/catenin complex to the platelet-derived growth factor receptor to modulate the actin cytoskeleton and regulate cell motility
    Christopher S Theisen
    Department of Biochemistry and Molecular Biology, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198 7696, USA
    Mol Biol Cell 18:1220-32. 2007
    ..These studies implicate N-cadherin and beta-catenin in cell migration via PDGF-R-mediated signaling through the scaffolding molecule NHERF...
  55. ncbi Deregulated Wnt/beta-catenin program in high-risk neuroblastomas without MYCN amplification
    X Liu
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    Oncogene 27:1478-88. 2008
    ..Thus, high-risk NBs without MYCN amplification may deregulate MYC and other oncogenic genes via altered beta-catenin signaling providing a potential candidate pathway for therapeutic inhibition...
  56. ncbi Frequent mutations of beta-catenin gene in sporadic secreting adrenocortical adenomas
    Mimi Tadjine
    Division of Endocrinology, Department of Medicine, Centre Hospitalier de l Universite de Montreal CHUM, Hotel Dieu, Montreal, Quebec, Canada
    Clin Endocrinol (Oxf) 68:264-70. 2008
    ..To better understand the role of Wnt/beta-catenin signalling in adrenocortical tumours, we performed mutational analysis of the beta-catenin gene...
  57. doi The intratumoral distribution of nuclear beta-catenin is a prognostic marker in colon cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität, Munich, Germany
    Cancer 115:2063-70. 2009
    ..Herein, the authors investigated whether the intratumoral distribution of nuclear beta-catenin can serve as a prognostic marker for survival and tumor progression of stage IIA colon cancer patients...
  58. pmc Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells
    Brian W Robertson
    Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Exp Cell Res 316:1-11. 2010
    ..This work describes an important aspect of cancer progression induced by OPN...
  59. pmc Nuclear beta-catenin overexpression in metastatic sentinel lymph node is associated with synchronous liver metastasis in colorectal cancer
    Hongxia Cheng
    Department of Pathology, Provincial Hospital affiliated to Shandong University, Jinan 250021, Shandong, People s Republic of China
    Diagn Pathol 6:109. 2011
    ..The purpose of this study is to investigate whether nuclear beta-catenin overexpression in metastatic sentinel lymph node(s) [SLN(s)] is associated with synchronous liver metastasis...
  60. pmc LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element
    Daniel Hebenstreit
    Department of Molecular Biology, University of Salzburg, 5020 Salzburg, Austria
    J Biol Chem 283:22490-7. 2008
    ..Furthermore, we found that IL-4 stimulation possesses a negative effect on the expressions of LEF-1 and TCF-1 in primary T cells, suggesting a positive feedback effect of IL-4 on IL4 gene expression...
  61. pmc Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling
    Arthit Chairoungdua
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Biol 190:1079-91. 2010
    ..Thus, exosomal packaging and release of cytosolic proteins can modulate the activity of cellular signaling pathways...
  62. pmc Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos
    H Yamamoto
    Department of Biochemistry, Hiroshima University School of Medicine, Japan
    Mol Cell Biol 18:2867-75. 1998
    ..These results indicate that Axil negatively regulates the Wnt signaling pathway by mediating GSK-3beta-dependent phosphorylation of beta-catenin, thereby inhibiting axis formation...
  63. doi Reduced membranous beta-catenin protein expression is associated with metastasis and poor prognosis in squamous cell carcinoma of the esophagus
    Po Kuei Hsu
    Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming University, School of Medicine, Taipei, Taiwan
    J Thorac Cardiovasc Surg 135:1029-35. 2008
    ..The clinical relevance and prognostic significance of the expression of these proteins were also analyzed...
  64. doi Low membranous expression of beta-catenin and high mitotic count predict poor prognosis in endometrioid carcinoma of the ovary
    Daniel G Rosen
    Department of Pathology, Baylor College of Medicine, Houston, TX, USA
    Mod Pathol 23:113-22. 2010
    ..Our data suggest that there is a need to define a better grading system for ovarian endometrioid carcinoma. Molecular markers such as beta-catenin and mitotic count could aid in defining this grading system...
  65. ncbi Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin
    H Nakagawa
    Department of Genetics, Osaka University Medical School, Suita City, Japan
    Cancer Res 58:5176-81. 1998
    ..These results suggest that the APCL protein may be involved in the Wnt/Wingless signal pathway, and the identification of a novel relative of APC may provide new insights into the function of APC...
  66. pmc Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1
    Yoana N Dimitrova
    Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 285:13507-16. 2010
    ..Siah-1 and TBL1 were found to bind to the same armadillo repeat domain of beta-catenin, suggesting that polyubiquitination of beta-catenin is regulated by competition ..
  67. ncbi Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses
    S I Matsuzawa
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 7:915-26. 2001
    ..Expression of Siah is induced by p53, revealing a way of linking genotoxic injury to destruction of beta-catenin, thus reducing activity of Tcf/LEF transcription factors and contributing to cell cycle arrest...
  68. pmc Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex
    Zhong Hua Gao
    Department of Oncological Sciences, Huntsman Cancer Institute, 2000 East North Campus Drive, University of Utah, Salt Lake City, UT 84112 5550, USA
    Proc Natl Acad Sci U S A 99:1182-7. 2002
    ..The data suggest that CKI phosphorylates and destabilizes the beta-catenin degradation complex, likely through the dissociation of PP2A, providing a mechanism by which CKI stabilizes beta-catenin and propagates the Wnt signal...
  69. pmc Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation
    Lilia Topol
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 162:899-908. 2003
    ..Furthermore, we provide evidence that Wnt-5a also acts in vivo to promote beta-catenin degradation in regulating mammalian limb development and possibly in suppressing tumor formation...
  70. pmc Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes
    Ming Zhang
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 285:8703-10. 2010
    ..Our findings demonstrate a novel mechanism between TGF-beta and Wnt/beta-catenin signaling pathways during chondrocyte development...
  71. doi Involvement of the TGF-beta and beta-catenin pathways in pelvic lymph node metastasis in early-stage cervical cancer
    Maartje G Noordhuis
    Department of Gynecologic Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Cancer Res 17:1317-30. 2011
    ..Aim of this study was to identify cellular tumor pathways associated with pelvic lymph node metastasis in early-stage cervical cancer...
  72. pmc Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4
    Kathryn C Davidson
    Department of Pharmacology, Howard Hughes Medical Institute, and the Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 109:4485-90. 2012
    ..Together these data support a dominant role for Wnt/β-catenin signaling in the differentiation rather than self-renewal of hESCs...
  73. pmc Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the beta-catenin signaling pathway
    Jianfei Qi
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    Mol Biol Cell 16:4386-97. 2005
    ..Transendothelial migration was compromised in cells expressing a dominant-negative form of beta-catenin, thus supporting a regulatory role of beta-catenin signaling in this process...
  74. doi Kaiso is a bimodal modulator for Wnt/beta-catenin signaling
    Hidekazu Iioka
    BRB 723, Department of Genetics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    FEBS Lett 583:627-32. 2009
    ..Our studies together provide insights into why Kaiso null mice display resistance to intestinal tumors when crossed onto an Apc(Min/+) background...
  75. doi Nonstructural 5A protein activates beta-catenin signaling cascades: implication of hepatitis C virus-induced liver pathogenesis
    Chul Yong Park
    National Research Laboratory of Hepatitis C Virus and Ilsong Institute of Life Science, Hallym University, Dongan Gu, Anyang, Republic of Korea
    J Hepatol 51:853-64. 2009
    ..Wnt/beta-catenin signaling has also been involved in tumorigenesis. To elucidate the molecular mechanism of HCV pathogenesis, we examined the potential effects of HCV NS5A protein on Wnt/beta-catenin signal transduction cascades...
  76. ncbi Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    Science 272:1023-6. 1996
    ..The APC protein binds to the cellular adhesion molecule beta-catenin, which is a mammalian homolog of ARMADILLO, a component of the WINGLESS signaling pathway in Drosophila development...
  77. ncbi Regulation of beta-catenin structure and activity by tyrosine phosphorylation
    J Piedra
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    J Biol Chem 276:20436-43. 2001
    ..Phosphorylation of Tyr-654, a residue placed in the last armadillo repeat of beta-catenin, decreases its binding to E-cadherin...
  78. ncbi Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers
    N Miwa
    Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Japan
    Oncol Res 12:469-76. 2001
    ..Our results imply that claudin-1 is involved in the beta-catenin-Tcf/LEF signaling pathway, and that increased expression of claudin-1 may have some role in colorectal tumorigenesis...
  79. doi Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner
    M Caspi
    Department of Anatomy and Anthropology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Oncogene 27:3546-55. 2008
    ..We show that GSK-3beta enters the nucleus, forms a complex with beta-catenin and lowers the levels of beta-catenin/TCF-dependent transcription in a mechanism that involves GSK-3beta-Axin binding...
  80. ncbi Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development
    C Kraus
    Institut für Humangenetik der Universität, Erlangen, Germany
    Genomics 23:272-4. 1994
    ..amplification of beta-catenin sequences were selected on the basis of homology to exon 4 of the Drosophila armadillo gene...
  81. ncbi Functional interaction between beta-catenin and FOXO in oxidative stress signaling
    Marieke A G Essers
    Department of Physiological Chemistry and Center for Biomedical Genetics, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, Netherlands
    Science 308:1181-4. 2005
    ..These results demonstrate a role for beta-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress...
  82. pmc Nuclear beta-catenin expression as a prognostic factor in advanced colorectal carcinoma
    Adam Elzagheid
    Department of Pathology, University of Turku, Kiinamyllynkatu 10, FIN 20520, Turku, Finland
    World J Gastroenterol 14:3866-71. 2008
    ..To investigate the changing pattern of beta-catenin expression and its prognostic value in advanced colorectal cancer (CRC)...
  83. pmc Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors
    Alexander J F Lazar
    Sarcoma Research Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4001, USA
    Am J Pathol 173:1518-27. 2008
    ..In conclusion, CTNNB1 mutations are highly common in desmoid tumors. Furthermore, patients harboring CTNNB1 (45F) mutations are at particular risk for recurrence and therefore may especially benefit from adjuvant therapeutic approaches...
  84. pmc Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model
    Andy J Chien
    Institute for Stem Cell and Regenerative Medicine, Department of Medicine, Division of Dermatology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 106:1193-8. 2009
    ..Our results may explain the observed loss of nuclear beta-catenin with melanoma progression in human tumors, which could reflect a dysregulation of cellular differentiation through a loss of homeostatic Wnt/beta-catenin signaling...
  85. pmc Associations of beta-catenin alterations and MSI screening status with expression of key cell cycle regulating proteins and survival from colorectal cancer
    Sakarias Wangefjord
    Department of Clinical Sciences, Division of Pathology, Lund University, Skane University Hospital, Lund, Sweden
    Diagn Pathol 8:10. 2013
    ..In this paper, we studied the associations between beta-catenin overexpression and MSI status with survival from CRC, and with expression of p21, p27, cyclin D1 and p53, in a large, prospective cohort study...
  86. ncbi The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin
    Jing Liu
    Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
    J Mol Biol 360:133-44. 2006
    ..In addition, our CD and NMR studies demonstrate that the central region of APC is unstructured in the absence of beta-catenin and Axin, and suggest that beta-catenin may interact with each of the APC 15aa and 20aa repeats independently...
  87. pmc Sulindac suppresses beta-catenin expression in human cancer cells
    Anjia Han
    Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Eur J Pharmacol 583:26-31. 2008
    ..In conclusion, our data demonstrated that the efficacy of sulindac in the inhibition of cell proliferation (rather than the induction of apoptosis) might be through the suppression of beta-catenin pathway in human cancer cells...
  88. pmc Overall expression of beta-catenin outperforms its nuclear accumulation in predicting outcomes of colorectal cancers
    Worrawit Wanitsuwan
    Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110 Thailand
    World J Gastroenterol 14:6052-9. 2008
    ..To examine the expression of beta-catenin in colorectal cancer and look for association with other clinico-pathological parameters...
  89. pmc SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability
    Min Jung Kim
    Department of Genetics and Development, 701 W 168th St, Columbia University Medical Center, New York, NY 10032, USA
    FASEB J 22:3785-94. 2008
    ..Therefore, some other specific property of the C6 motif seems to reduce the interaction of Axin with Dvl-1...
  90. pmc Issues associated with assessing nuclear localization of N-terminally unphosphorylated beta-catenin with monoclonal antibody 8E7
    Meghan T Maher
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Biol Direct 4:5. 2009
    ....
  91. doi Wnt/β-catenin pathway activation in adrenocortical adenomas is frequently due to somatic CTNNB1-activating mutations, which are associated with larger and nonsecreting tumors: a study in cortisol-secreting and -nonsecreting tumors
    Stephane Bonnet
    Department of Endocrinology, Metabolism, and Cancer, Institut National de la Santé et de la Recherche Médicale Unité 1016, Paris, France
    J Clin Endocrinol Metab 96:E419-26. 2011
    ....
  92. doi β-catenin and Her2/neu expression in rectal cancer: association with histomorphological response to neoadjuvant therapy and prognosis
    Uta Drebber
    Institute of Pathology, University Hospital Cologne, Kerpener Str 62, 50937, Cologne, Germany
    Int J Colorectal Dis 26:1127-34. 2011
    ..We examined the association of β-catenin and Her2/neu protein expression with histopathologic response to neoadjuvant radiochemotherapy and prognosis in patients with locally advanced rectal cancer...
  93. doi Prognostic significance of cyclin D1, β-catenin, and MTA1 in patients with invasive ductal carcinoma of the breast
    Chun Wen Cheng
    Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
    Ann Surg Oncol 19:4129-39. 2012
    ....
  94. pmc Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
    D Levanon
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 95:11590-5. 1998
    ..signaling pathway through interactions with the coactivator beta-catenin and its highly conserved fly homolog Armadillo (Arm)...
  95. pmc beta-Catenin is a Nek2 substrate involved in centrosome separation
    Shirin Bahmanyar
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Genes Dev 22:91-105. 2008
    ..These results identify beta-catenin as a component of the intercentrosomal linker and define a new function for beta-catenin as a key regulator of mitotic centrosome separation...
  96. doi Aberrant changes of Wnt2/beta-catenin signaling pathway induced by sodium nitroprusside in human esophageal squamous cell carcinoma cell lines
    Wei Wang
    Laboratory for Cell Biology, The First Affiliated Hospital, Zhengzhou University, 40 Daxue Road, Zhengzhou, Henan 450052, China
    Cancer Invest 28:230-41. 2010
    ....
  97. pmc β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation
    I Ahmad
    The Beatson Institute for Cancer Research, Glasgow, Scotland, UK
    Oncogene 30:178-89. 2011
    ..Taken together these data show that deregulated Wnt signalling has a critical role in promoting UCC, and suggests that human UCC that have high levels of Wnt and PI3 kinase signalling may be responsive to mTOR inhibition...
  98. doi Phosphorylation of β-catenin results in lack of β-catenin signaling in melanoma
    Silke Kuphal
    University of Regensburg, Institute of Pathology, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Int J Oncol 39:235-43. 2011
    ..In summary, this study suggests a cell type-specific regulation of β-catenin function. This alternative β-catenin signaling pathway should be considered when thinking about targeting β-catenin in melanoma treatment...
  99. doi Activation of voltage gated K⁺ channel Kv1.5 by β-catenin
    Carlos Munoz
    Department of Physiology, University of Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Biochem Biophys Res Commun 417:692-6. 2012
    ..5 requires the same protein domains that are required for association of β-catenin with cadherin. The experiments disclose a completely novel function of β-catenin, i.e. the regulation of Kv1.5 channel activity...
  100. doi The complex intratumoral heterogeneity of colon cancer highlighted by laser microdissection
    David Buob
    Department of Pathology, CHRU de Lille, Centre de Biologie Pathologie, Avenue Oscar Lambret, 59037 Lille Cedex, France
    Dig Dis Sci 57:1271-80. 2012
    ..To evaluate the utility of laser microdissection in the comparison of phenotypes and genetic alterations between colon cancer and corresponding liver metastasis in the context of intratumoral heterogeneity...
  101. ncbi Beta-catenin accumulation and mutation of the CTNNB1 gene in hepatoblastoma
    H Blaker
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Genes Chromosomes Cancer 25:399-402. 1999
    ..Genes Chromosomes Cancer 25:399-402, 1999...

Research Grants36

  1. ELIZABETH ANN EKLUND; Fiscal Year: 2016
    ..Targeting these mechanisms may lead to cure in CML by abolishing the CSC/LSC, and suggest therapeutic approaches to other forms of cancer with dysregulation of Fas and bcatenin. ..
  2. A Validated Resource of Thyroid Cancer Cell Lines for Pathway Discovery
    JEFFREY ALLEN KNAUF; Fiscal Year: 2010
    ....
  3. ELIZABETH ANN EKLUND; Fiscal Year: 2016
    ..The goal of these studies is to identify molecular mechanisms that lead to LSC persistence, and therefore TKI resistance and/or BC in CML. Targeting these mechanisms might cure CML by abolishing the LSC. ..
  4. SATDARSHAN SINGH MONGA; Fiscal Year: 2016
    ..All the proposed studies in the grant will utilize a balance of i vitro and in vivo set of experiments and the expected outcomes will be highly relevant and translational. ..
  5. Tanner J Freeman; Fiscal Year: 2015
    ..By knocking out Smad4 on the background of well-characterized mouse models with Apc mutations, this model closely recapitulates the pathogenesis of colorectal cancer. ..
  6. MSX2-Wnt Signaling in Cardiovascular Calcification
    Dwight A Towler; Fiscal Year: 2013
    ..physiological rationale and validation for reducing VSMC 2-catenin levels and LRP6 signaling as a potential therapeutic strategy to ameliorate vascular calcification -- and thus reduce lower extremity amputation risk in type II diabetes ..
  7. Role of Ectodermal Signals in Facial Prominence Outgrowth and Development
    Trevor J Williams; Fiscal Year: 2013
    ..abstract_text> ..
  8. Kenneth W Kinzler; Fiscal Year: 2016
    ..It can be argued that understanding these early changes is essential for the development of more effective strategies for colorectal tumor prevention and treatment. ..
  9. WT1 and beta-catenin targets in Wilms tumor
    Benjamin Tycko; Fiscal Year: 2007
    ..other phosphorylation sites in affecting the proliferative/oncogenic potency of beta-catenin. We will subsequently cross these mice with Wt1-mutant heterozygotes, possibly generating a mouse model for Wilms tumor. ..
  10. Deciphering Beta-Catenin Contributions in Prostate Cance
    David Mulholland; Fiscal Year: 2008
    ..These cells will be assessed for growth and PSA secretion in tumours carried as xenografts. These novel in vivo tools will allow understanding to the role of Beta-catenin has in Al PrCa. ..
  11. VITAMIN D AND THE DIFFERENTIATION OF KERATINOCYTES
    Daniel Bikle; Fiscal Year: 2003
    ..abstract_text> ..
  12. REGULATION OF INTESTINAL CALCIUM TRANSPORT BY VITAMIN D
    Daniel Bikle; Fiscal Year: 2001
    ..These manipulations will all be tested for their ability to block 1,25D-stimulated calcium transport. ..
  13. The Neurotransmitter dopamine and angiogenesis
    Debabrata Mukhopadhyay; Fiscal Year: 2007
    ..abstract_text> ..
  14. BIOLOGY OF BAMACAN IN TUMORIGENESIS
    Giancarlo Ghiselli; Fiscal Year: 2006
    ..3) The contribution of bamacan in vivo to colon tumorigenesis by generating transgenic mice over-expressing bamacan in the intestinal epithelium. ..
  15. Restoration of beta-catenin signaling by perillyl alcoh*
    Wen Chi Chang; Fiscal Year: 2005
    ..Results from the proposed research will determine the feasibility of developing POH as a chemopreventive agent for patients with colorectal cancer and provide the basis for future R01 funding. ..
  16. RAS MEDIATED, ANCHORAGE INDEPENDENT GROWTH
    ROBERT KRAUSS; Fiscal Year: 2002
    ..Such genes represent potential mediators of the transformed phenotype. ..
  17. MUCOSAL PROTECTIVE FACTORS IN HUMAN MILK
    Radhakrishna Rao; Fiscal Year: 2003
    ..protective factors in breast milk, and provide the basis for further characterization of the mechanisms involved in mucosal protection by breast milk, and their role in preventing neonatal gastrointestinal diseases ..
  18. Role of CD164 in Skeletal Myogenesis
    ROBERT KRAUSS; Fiscal Year: 2008
    ..This research should therefore shed light on fundamental processes by which skeletal muscles develop. [unreadable] [unreadable]..
  19. Gene-Environment Interaction in Holoprosencephaly: Role of Fetal Alcohol Exposure
    ROBERT KRAUSS; Fiscal Year: 2008
    ..Such information may have important public health impact and could ultimately aid in the counseling of HPE mutation carriers. [unreadable] [unreadable] [unreadable]..
  20. PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION
    Henry Lynch; Fiscal Year: 2004
    ....
  21. International Meeting--Epithelial /Mesenchymal Tranition
    Raghu Kalluri; Fiscal Year: 2005
    ..abstract_text> ..
  22. Novel Therapeutic Strategies for PKD
    Patricia Wilson; Fiscal Year: 2007
    ..abstract_text> ..
  23. ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
    Raghu Kalluri; Fiscal Year: 2001
    ..Successful completion of this project should provide new experimental information regarding the processes that govern the pathogenesis of human anti-GBM disease. ..
  24. Mice That Lack CDO: A Model for Mild Holoprosencephaly
    ROBERT KRAUSS; Fiscal Year: 2004
    ....
  25. Regulation and Function of MAPKAP Kinases
    Thomas Sturgill; Fiscal Year: 2005
    ..Aim four is to characterize the activation, enzymatic properties, and functions of MAPKAP kinase-like enzymes (Rcklp, Rck2p) in yeast, a model eukaryote, using combined biochemical and genetic approaches. ..
  26. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2010
    ..The role of such fibroblasts in cancer progression and metastasis is unknown. This proposal addresses the role of fibroblasts in facilitating metastasis. ..
  27. mTOR Signaling Pathways
    Thomas W Sturgill; Fiscal Year: 2010
    ..We will investigate novel candidate mTOR-interacting proteins identified by MS. Finally, to understand better the mechanisms involved in mTORC2, we propose to identify pianissimo-interacting proteins. ..
  28. The Biology and Function of BMP-7 in the Kidney
    Raghu Kalluri; Fiscal Year: 2007
    ..The physiological role of BMP-7 in kidney health and pathology will be established. These studies will directly benefit the development of this molecule in the clinic as a drug for patients with kidney fibrosis. ..
  29. InteractiveSlides - Microarray data visualization tool
    Jozef Spychala; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  30. APC PATHWAY--A TARGET FOR CHEMOPREVENTIVE INTERVENTION
    Wen Chi Chang; Fiscal Year: 2005
    ..in nutritional biochemistry when combined with the proposed training in cancer prevention and molecular genetics will provide her with the unique ability to develop both natural and synthetic compounds as clinical chemopreventive agents ..
  31. Role of Plakophilin-1 in HNSCC
    James Wahl; Fiscal Year: 2009
    ..Plakophilin-1 is a member of the Armadillo (Arm) protein family that is a structural component of the cell-cell adhesion junction known as the desmosome...
  32. Early Events in Colitis-Associated Colorectal Cancer
    Wen Chi Chang; Fiscal Year: 2003
    ..abstract_text> ..
  33. The role of PIKE-S in mediating EGFR mitogenic signaling in OSCC cells
    Zhongjian Xie; Fiscal Year: 2008
    ..Understanding these mechanisms will bring the possibility of new molecular targets for development novel therapeutic options for the control of oral squamous cell carcinoma. [unreadable] [unreadable] [unreadable]..
  34. Matrix Microenvironment and Liver Fibrosis
    Raghu Kalluri; Fiscal Year: 2007
    ..Therefore, this application is well poised to identify a unique mechanism of liver fibrosis and also study a therapeutic agent, which works against this mechanism and inhibits progression of liver disease. ..
  35. Regulation of Angiogenesis by Tumstatin
    Raghu Kalluri; Fiscal Year: 2006
    ..abstract_text> ..