Genomes and Genes
Gene Symbol: beta-actin
Description: actin beta
Alias: BRWS1, PS1TP5BP1, actin, cytoplasmic 1, PS1TP5-binding protein 1, beta cytoskeletal actin
Publications283 found, 100 shown here
- Expression of the hepatic insulin receptor gene in the rat during postnatal developmentE Tozzo
, Centre Hospitalier Necker Enfants Malades, Paris, France
Horm Metab Res 27:163-8. 1995..5 and 7.5 kb. When normalized to beta actin mRNA, insulin receptor mRNA levels increased 4-fold between 1 and 15 days, remained stable between 15 and 30 ..
- beta-Actin messenger RNA localization and protein synthesis augment cell motilityE H Kislauskis
Department of Cell Biology, University of Massachusetts Medical School, Worcester 01655, USA
J Cell Biol 136:1263-70. 1997..The serum induction of cell movement was also inhibited by antizipcode ODNs. These observations support the hypothesis that beta-actin mRNA localization and consequent protein synthesis augment cell motility...
- A role for Rev in the association of HIV-1 gag mRNA with cytoskeletal beta-actin and viral protein expressionT Kimura
Department of Microbiology, Kansai Medical University, Osaka, Japan
Biochimie 78:1075-80. 1996....
- Actin deficiency induces cofilin phosphorylation: proteome analysis of HeLa cells after beta-actin gene silencingNing Liu
Bio Rad Laboratories, Inc, Hercules, California 94547, USA
Cell Motil Cytoskeleton 64:110-20. 2007..This study also demonstrates that the combination of RNA interference and 2-dimensional gel electrophoresis technologies provides a valuable method to study protein interactions in a specific cellular pathway...
- Beta-actin association with endothelial nitric-oxide synthase modulates nitric oxide and superoxide generation from the enzymeDmitry Kondrikov
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912, USA
J Biol Chem 285:4319-27. 2010..Modulation of NO and superoxide formation from eNOS by beta-actin plays an important role in endothelial function...
- A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNASébastien Lyonnais
AIDS Research Group, IDIBAPS, E 08036 Barcelona, Spain
Virus Res 171:287-303. 2013....
- N-terminal Slit2 inhibits HIV-1 replication by regulating the actin cytoskeletonAppakkudal R Anand
Department of Pathology, Ohio State University Wexner Medical Center, 460 W 12th Avenue, 810 Biological Research Tower, Columbus, OH 43210, USA
Retrovirology 10:2. 2013..Slit2 is a ~ 200 kDa secreted glycoprotein that has been recently shown to regulate immune functions. However, not much is known about its role in HIV (human immunodeficiency virus)-1 pathogenesis...
- Gelsolin activity controls efficient early HIV-1 infectionLaura García-Expósito
Cellular and Viral Immunology Lab, Department of Physical Medicine and Pharmacology, School of Medicine, University of La Laguna, Campus de Ofra s n, Tenerife 38071, Spain
Retrovirology 10:39. 2013..However, it remains unclear whether the dynamic processing of F-actin and the amount of cortical actin available during the initial virus-cell contact are required to such events...
- A posttranslational modification of beta-actin contributes to the slow dissociation of the spectrin-protein 4.1-actin complex of irreversibly sickled cellsA Shartava
Department of Structural and Cellular Biology, University of South Alabama College of Medicine, Mobile 36688
J Cell Biol 128:805-18. 1995....
- Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycleS Yokota
HSP Research Institute, Kyoto Research Park, Shimogyo ku, Kyoto, Japan
Eur J Biochem 268:4664-73. 2001..These results suggest that the content of alpha and delta subunits of CCT reduces from the complete active complex in S phase cells to incomplete inactive complex in M phase cells...
- Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteinsVincent C Chen
Department of Chemistry, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada
J Proteome Res 5:2123-34. 2006....
- Essential and supporting host cell factors for HIV-1 buddingAurelien Dordor
Unit of Virus Host Cell Interactions UMI 3265 Université Joseph Fourier EMBL CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France
Future Microbiol 6:1159-70. 2011..Here we review recent advances in understanding the role of host cell factors recruited by Gag during HIV-1 assembly and budding...
- HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitinationPrabha Chandrasekaran
Laboratory of Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 287:41481-98. 2012..By specifically degrading Gα(i2), Nef directly subverts leukocyte migration and homing. Impaired trafficking and homing of HIV Nef-expressing lymphocytes probably contributes to early immune dysfunction following HIV infection...
- The nucleocapsid domain of Gag is dispensable for actin incorporation into HIV-1 and for association of viral budding sites with cortical F-actinSarah Stauffer
Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany Oxford Particle Imaging Centre, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
J Virol 88:7893-903. 2014..Furthermore, actin was not enriched in the virus compared to the average levels in the respective producing cell. Our data argue against a specific recruitment of actin to HIV-1 budding sites by the nucleocapsid domain of Gag...
- HIV-1 protease cleaves actin during acute infection of human T-lymphocytesL D Adams
Biochemistry Unit, Upjohn Laboratories, Kalamazoo, MI 49001
AIDS Res Hum Retroviruses 8:291-5. 1992..Hydrolysis by the HIV-1 protease of physiologically important host cellular proteins during infection may have important consequences relative to viral pathogenesis...
- Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEFH Zhang
The Lineberger Comprehensive Cancer Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Curr Biol 9:1271-4. 1999..These findings suggest that an important function of gp41C is to modulate the activity of p115-RhoGEF and they thus reveal a new potential anti-HIV-1 target...
- HIV-1 Nef triggers Vav-mediated signaling pathway leading to functional and morphological differentiation of dendritic cellsMaria Giovanna Quaranta
Department of Immunology, Istituto Superiore di Sanità Viale Regina Elena, 299 00161 Rome, Italy
FASEB J 17:2025-36. 2003..Our results highlight how Nef may enhance T lymphocyte activation, thus fostering virus dissemination, manipulating the DC arm of the immune response...
- Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56lckAllison Olszewski
Department of Chemistry, University of California, Irvine, CA 92697 2025, USA
Proc Natl Acad Sci U S A 101:14079-84. 2004..Although compounds that are effective in vitro proved to be too cytotoxic for cellular assays, the reported Nef inhibitors provide proof-of-concept for disrupting a new HIV target and offer useful leads for drug development...
- Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in miceZhenglin Yang
Department of Ophthalmology and Visual Science, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah, USA
J Clin Invest 118:2908-16. 2008..Collectively, our results identify what we believe to be a novel complex involved in photoreceptor disk morphogenesis and indicate a possible role for PROM1 and PCDH21 in macular degeneration...
- Nuclear myosin II regulates the assembly of preinitiation complex for ICAM-1 gene transcriptionQingjie Li
Department of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1083, USA
Gastroenterology 137:1051-60, 1060.e1-3. 2009..We do not know whether myosin II and actins in the nucleus function as motors to generate relative motion, such as that between RNA polymerase II holoenzyme and DNA, for assembly of the preinitiation complex...
- Cloning of human erythroid dematin reveals another member of the villin familyA P Rana
Department of Biomedical Research, St Elizabeth s Hospital, Tufts University School of Medicine, Boston, MA 02135
Proc Natl Acad Sci U S A 90:6651-5. 1993..The widespread expression of dematin transcripts in human tissues suggests that dematin and its homologues may substitute for villin in villin-negative tissues to regulate actin reorganization by a phosphorylation-regulated mechanism...
- HIV-1 Gag protein associates with F-actin present in microfilamentsO Rey
Department of Pediatrics, School of Medicine, University of California at Los Angeles 90095, USA
Virology 220:530-4. 1996..In vivo and in vitro analyses of this interaction indicated that the unprocessed Gag polyprotein is capable of association with polymerized actin (F-actin). Binding of Gag to F-actin may be involved in the assembly or budding of HIV-1...
- Cytoskeletal proteins inside human immunodeficiency virus type 1 virionsD E Ott
AIDS Vaccine Program, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
J Virol 70:7734-43. 1996..The presence of these fragments, as well as the incorporation of a few specific cytoskeletal proteins into virions, suggests an active interaction between cytoskeletal and viral proteins...
- Beta cap73: a novel beta actin-specific binding proteinC B Shuster
Program in Cell, Molecular, and Developmental Biology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Cell Motil Cytoskeleton 35:175-87. 1996..Cell Biol. 128:837-848]. To identify the beta actin-specific binding protein that fosters ezrin-beta actin interactions, we developed an isoactin affinity ..
- Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeletonA Bukrinskaya
Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts 01605, USA
J Exp Med 188:2113-25. 1998....
- Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signalingK Zhao
Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, California 94305 5323, USA
Cell 95:625-36. 1998..This work indicates that membrane signals control the activity of the mammalian SWI/SNF or BAF complex and demonstrates a direct interface between signaling and chromatin regulation...
- Actin associates with the nucleocapsid domain of the human immunodeficiency virus Gag polyproteinT Wilk
Structural Biology Programme, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
J Virol 73:1931-40. 1999..The same result was obtained when mature HIV-1 particles were disrupted with detergent. Taken together, these results indicate that actin molecules are associated with the NC domain of the viral polyprotein...
- Interaction of the human immunodeficiency virus type 1 nucleocapsid with actinB Liu
Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
J Virol 73:2901-8. 1999....
- A heterozygous mutation of beta-actin associated with neutrophil dysfunction and recurrent infectionH Nunoi
Institute of Medical Science, University of Tokyo, Minatoku, Tokyo 108 8639, Japan
Proc Natl Acad Sci U S A 96:8693-8. 1999..Heterozygous expression of mutant beta-actin in neutrophils and other cells of this patient may act in a dominant-negative fashion to adversely affect cellular activities dependent on the function of nonmuscle actin...
- The golgi-associated COPI-coated buds and vesicles contain beta/gamma -actinF Valderrama
Departament de Biologia Cellular, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, 08036 Barcelona, Spain
Proc Natl Acad Sci U S A 97:1560-5. 2000....
- Relationship between contact inhibition and intranuclear S100C of normal human fibroblastsM Sakaguchi
Department of Cell Biology, Institute of Molecular and Cellular Biology, Okayama University Medical School, Okayama 700 8558, Japan
J Cell Biol 149:1193-206. 2000..These data indicate the possible involvement of nuclear S100C in the contact inhibition of cell growth...
- Specific changes to the mechanism of cell locomotion induced by overexpression of beta-actinM Peckham
School of Biomedical Sciences, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
J Cell Sci 114:1367-77. 2001....
- HIV type 1 Gag and nucleocapsid proteins: cytoskeletal localization and effects on cell motilityF J Ibarrondo
Department of Pediatrics, UCLA School of Medicine, Los Angeles, California 90095, USA
AIDS Res Hum Retroviruses 17:1489-500. 2001..These data suggest that interactions between HIV-1 Gag and actin in infected cells enhance cell motility. Ultimately this enhanced motility of infected cells could promote the dissemination of virus into the brain and other tissues...
- Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilinRyusuke Niwa
Department of Molecular Genetics, The Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
Cell 108:233-46. 2002..Furthermore, SSH and the hSSHs dephosphorylated P cofilin in cultured cells and in cell-free assays. Our results strongly suggest that the SSH family plays a pivotal role in actin dynamics by reactivating ADF/cofilin in vivo...
- Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulationYizeng Tu
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Cell 113:37-47. 2003..Together, Mig-2, migfilin and filamin define a connection between cell matrix adhesions and the actin cytoskeleton and participate in the orchestration of actin assembly and cell shape modulation...
- Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexesTheis Stüven
ZMBH, INF 282, D 69120 Heidelberg and Universität Lübeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
EMBO J 22:5928-40. 2003..In contrast to a previous report, we found no indications of a major and direct role for CRM1 in actin export from mammalian or insect nuclei...
- Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteinsPatrick B Allen
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
Proc Natl Acad Sci U S A 101:7187-92. 2004..The current findings present a mechanism by which PP1 may be directed toward neuronal substrates associated with the actin cytoskeleton...
- Disruption of the actin cytoskeleton can complement the ability of Nef to enhance human immunodeficiency virus type 1 infectivityEdward M Campbell
Department of Microbiology and Immunology, University of Illinois at Chicago, 835 S Wolcott, Chicago, IL 60612, USA
J Virol 78:5745-55. 2004..The results presented here suggest that Nef functions to allow the HIV genome to penetrate the cortical actin network, a known barrier for intracellular parasitic organisms...
- Nuclear actin and myosin I are required for RNA polymerase I transcriptionVlada V Philimonenko
Department of Cell Ultrastructure and Molecular Biology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague 14220, Czech Republic
Nat Cell Biol 6:1165-72. 2004..The association with Pol I requires phosphorylation of TIF-IA at Ser 649 by RSK kinase, indicating a role for NMI in the growth-dependent regulation of rRNA synthesis...
- Beta-actin in human colon adenocarcinoma cell lines with different metastatic potentialDorota Nowak
Department of Cell Pathology, Institute of Biochemistry and Molecular Biology, University of Wrocław, Wrocław, Poland
Acta Biochim Pol 52:461-8. 2005..beta-actin subcellular localization was done by immunofluorescence staining with monoclonal anti-beta actin antibodies...
- Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and spread of human immunodeficiency virus type 1Clare Jolly
The Sir William Dunn School of Pathology, The University of Oxford, Oxford OX1 3RE, United Kingdom
J Virol 81:5547-60. 2007..Based on these data, we propose that HIV-1 requires both actin and tubulin components of the T-cell cytoskeleton to direct its assembly and budding and to elaborate a functional VS...
- The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a U-rich-element-dependent mannerVirginie Dormoy-Raclet
Department of Biochemistry, and McGill Cancer Center, McGill University, McIntyre Building, Room 904, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
Mol Cell Biol 27:5365-80. 2007....
- Selective targeting of ITK blocks multiple steps of HIV replicationJulie A Readinger
Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 105:6684-9. 2008..Our data suggest that inhibition of ITK blocks HIV infection by affecting multiple steps of HIV replication...
- HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cellsAlyson Yoder
Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
Cell 134:782-92. 2008..Conversely, induction of active cofilin greatly facilitates it. These findings shed light on viral exploitation of cellular machinery in resting T cells, where chemokine receptor signaling becomes obligatory...
- Beta and gamma-cytoplasmic actins display distinct distribution and functional diversityVera Dugina
Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
J Cell Sci 122:2980-8. 2009..Our results reveal new aspects of beta- and gamma-actin organization that support their functional diversity...
- Human immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapseGaia Vasiliver-Shamis
Program in Molecular Pathogenesis, Marty and Helen Kimmel Center for Biology and Medicine, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
J Virol 83:11341-55. 2009..We propose a model in which the F-actin-depleted zone formed within the target CD4 T cell enhances the reception of virions by releasing the physical barrier for HIV-1 entry and facilitating postentry events...
- Retroviral assembly and budding occur through an actin-driven mechanismMicha Gladnikoff
Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
Biophys J 97:2419-28. 2009..The results of this study show that retroviruses utilize the cell cytoskeleton to expedite their assembly and budding...
- Molecular mechanisms underlying nucleocytoplasmic shuttling of actinin-4Masahiro Kumeta
Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
J Cell Sci 123:1020-30. 2010....
- The PDZ-adaptor protein syntenin-1 regulates HIV-1 entryMónica Gordón-Alonso
Servicio de Inmunologia, Instituto de Investigación Sanitaria de la Princesa, Hospital Universitario de la Princesa, 28006 Madrid, Spain
Mol Biol Cell 23:2253-63. 2012..Once the virus has entered the target cell, syntenin-1 polarization toward the viral nucleocapsid is lost, suggesting a spatiotemporal regulatory role of syntenin-1 in actin remodeling, PIP(2) production, and the dynamics of HIV-1 entry...
- The trinity of the cortical actin in the initiation of HIV-1 infectionMark Spear
National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
Retrovirology 9:45. 2012..It is the purpose of this review to examine, in detail, the manifestation of viral dependence on the actin cytoskeleton, and present a model of how HIV utilizes actin dynamics to initiate infection...
- ACTB in cancerChunmei Guo
Department of Biotechnology, Dalian Medical University, Dalian 116044, China
Clin Chim Acta 417:39-44. 2013..The current review explores relevant mechanisms, integrates current understandings, and provides suggestions for future studies of the roles of ACTB in tumors...
- The cleavage of host cell proteins by HIV-1 proteaseJ Snasel
Department of Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Folia Biol (Praha) 42:227-30. 1996
- Human immunodeficiency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant productionRu Feng Wu
The University of Texas Southwestern Medical Center and the Dallas Veterans Administration Medical Center, Dallas, Texas 75216, USA
J Virol 78:779-89. 2004..We conclude that Tat induces actin cytoskeletal rearrangements through PAK1 and downstream activation of the endothelial NADPH oxidase...
- A role for beta-actin in RNA polymerase III transcriptionPing Hu
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Genes Dev 18:3010-5. 2004..Transcription is regained upon treatment of pol III with CK2 and addition of beta-actin. This suggests that beta-actin associated with pol III is essential for basal pol III transcription...
- HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRETEmma Poole
Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
Traffic 6:741-55. 2005..HIV-1 Psi thus acts as a subcellular localisation signal as well as a high-affinity-binding site for Gag...
- Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expressionMayte Coiras
AIDS Immunopathology Unit, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
Proteomics 6:S63-73. 2006..In conclusion, in addition to its role in viral mRNA elongation, the proteomic approach has provided insight into the way that Tat modifies host cell gene expression...
- HIV-1 replication from after cell entry to the nuclear peripheryDavid Warrilow
Division of Immunology and Infectious Disease, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Curr HIV Res 5:293-9. 2007..An actin-transport process may then facilitate the remaining short journey to the nuclear membrane...
- Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virusA G Tomasselli
Upjohn Laboratories, Upjohn Company, Kalamazoo, Michigan 49001
J Biol Chem 266:14548-53. 1991....
- Non-viral cellular substrates for human immunodeficiency virus type 1 proteaseR L Shoeman
Max Planck Institut für Zellbiologie, Ladenburg Heidelberg, Germany
FEBS Lett 278:199-203. 1991....
- The large subunit of HIV-1 reverse transcriptase interacts with beta-actinM Hottiger
Department of Veterinary Biochemistry, University of Zurich Irchel, Switzerland
Nucleic Acids Res 23:736-41. 1995..The reverse transcriptase/beta-actin interaction might be important for the secretion of HIV-1 virions...
- Indirect association of ezrin with F-actin: isoform specificity and calcium sensitivityC B Shuster
Program in Cell, Molecular, and Developmental Biology, Tufts University Health Science Schools, Boston, Massachusetts 02111
J Cell Biol 128:837-48. 1995..and E64, two specific inhibitors of the calcium-activated protease, calpain I, protect ezrin binding to beta actin in the presence of calcium...
- Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localizationO T Fackler
Universitatskliniken des Saarlandes, Institut für Med Mikrobiologie und Hygiene, Abt Virologie, Homburg Saar, Germany
Eur J Biochem 247:843-51. 1997..This novel interaction of HIV-1 Nef with actin provides insight into the association of Nef with cellular structures and reveals general differences in the interactions of the Nef proteins from HIV-1 and HIV-2...
- In vitro interaction of the carboxy-terminal domain of lamin A with actinA M Sasseville
Centre de recherche du Centre Hospitalier de l Université de Montréal and Institut du cancer de Montréal, Que, Canada
FEBS Lett 425:485-9. 1998..This result suggests that an actin-based molecular motor linked to the lamina could be involved in the movement of chromatin domains...
- Lasp-1, a novel type of actin-binding protein accumulating in cell membrane extensionsV Schreiber
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP Strasbourg, Illkirch, France
Mol Med 4:675-87. 1998..Altogether, our results show that Lasp-1 defines a new type of actin-binding protein and suggest that the protein may play a role in a signaling pathway involved in the organization of the cytoskeleton...
- Rev-dependent association of the intron-containing HIV-1 gag mRNA with the nuclear actin bundles and the inhibition of its nucleocytoplasmic transport by latrunculin-BT Kimura
Departments of Microbiology and Physiology, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
Genes Cells 5:289-307. 2000..A hallmark of HIV-1 gene expression is that unspliced genomic RNA, which also acts as mRNA for the expression of Gag/Pol, is exported to the cytoplasm. Rev directs this transport through the nuclear export signal (NES)...
- Association of emerin with nuclear and cytoplasmic actin is regulated in differentiating myoblastsGiovanna Lattanzi
ITOI CNR, Unit of Bologna, c o IOR, Via di Barbiano, 1 10, I 40136 Bologna, Italy
Biochem Biophys Res Commun 303:764-70. 2003..These data provide evidence of a modulation of emerin-actin interaction in muscle cells, possibly through differentiation-related stimuli...
- Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-betaAndrea E Varga
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Oncogene 24:5043-52. 2005..Together these results suggest that epigenetic suppression of TPM1 may alter TGF-beta tumor suppressor function and contribute to metastatic properties of tumor cells...
- Regulating the functions of the HIV-1 matrix proteinAnna C Hearps
Nuclear Signalling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
AIDS Res Hum Retroviruses 23:341-6. 2007..J Virol 2005;79:13028-13036) confirms the importance of this protein for HIV infection and highlights a potentially new avenue in multivalent drug therapy...
- Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic toleranceCristina Cid
Department of Investigation, Hospital Ramon y Cajal, Madrid, Spain
Proteomics 7:3207-18. 2007..It supports a potential role of PP1 in IR stress and as a target of the endogenous protective mechanisms induced by IT...
- Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MALStephane Mouilleron
Structural Biology Laboratory, Cancer Research UK, London Research Institute, London, UK
EMBO J 27:3198-208. 2008..Comparison with other actin-binding proteins reveals an unexpected similarity to the vitamin-D-binding protein, extending the G-actin-binding protein repertoire...
- Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodelingBettina Stolp
Department of Infectious Diseases, Virology, University of Heidelberg, INF 324, 69120 Heidelberg, Germany
J Virol 84:3935-48. 2010....
- HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to human brain microvascular endothelial cells via gp41 core-induced membrane activitiesSheng He Huang
Division of Infectious Diseases, Saban Research Institute, Childrens Hospital Los Angeles, University of Southern California, Keck School of Medicine, Los Angeles, CA 90027, USA
Biochem J 438:457-66. 2011..neoformans binding to HBMECs via gp41 core domain-induced membrane activities, revealing a potential mechanism of invasion for this pathogenic fungus into the brain tissues of HIV-1-infected patients...
- LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytesMohammad Ishaq
Laboratory of Molecular Cell Biology, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
BMC Mol Biol 12:41. 2011..Here we have investigated the role of actin dynamics and the effect of actin cytoskeleton modifying agents on retinoid receptor-mediated transactivation...
- A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystoniaVincent Procaccio
Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA 92697, USA
Am J Hum Genet 78:947-60. 2006..These findings suggest that mutations in nonmuscle actins may be associated with a broad spectrum of developmental malformations and/or neurological abnormalities such as dystonia...
- Effects of protein kinase C alpha overexpression on A7r5 smooth muscle cell proliferation and differentiationS Wang
Department of Physiology, Marshall University School of Medicine, Huntington, West Virginia 25755, USA
Exp Cell Res 236:117-26. 1997..These findings suggest that PKC alpha regulates growth and differentiation of A7r5 smooth muscle cells and that these changes might result from altered expression/function of AP-1 transcription factors...
- Expression of transforming growth factor-beta1 and transforming growth factor-beta Type-II receptor mRNA in papillary thyroid carcinomaH Matoba
First Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
Horm Metab Res 30:624-8. 1998..The reduction of TGF-beta Type-II receptor mRNA may play a role in the pathogenesis of papillary thyroid carcinoma...
- A beta-galactosidase hybrid protein targeted to nuclei as a marker for developmental studiesC Bonnerot
, , Paris
Proc Natl Acad Sci U S A 84:6795-9. 1987..Thus, transcriptional specificity must already be present at the stage of activation of the embryonic genome...
- Expression of an orphan nuclear receptor DAX-1 in human pituitary adenomasS Ikuyama
Third Department of Internal Medicine, Kyushu University Faculty of Medicine, Fukuoka, Japan
Clin Endocrinol (Oxf) 48:647-54. 1998..CONCLUSIONS: The results shown here indicate that DAX-1 is expressed in the majority of human pituitary adenomas of gonadotrophic origin in parallel with Adrenal-4-binding protein/steroidogenic factor-1...
- Validation of endogenous controls for gene expression studies in human adipocytes and preadipocytesK Gorzelniak
Franz-Volhard-Klinik, , , Germany
Horm Metab Res 33:625-7. 2001..Only GAPDH and transferrin receptor gene expression levels did not change under any of the stimuli tested, thus appeared best suited for gene expression studies in human adipose cells across a wide range of experimental settings...
- Oncogene expression in vivo by ovarian adenocarcinomas and mixed-mullerian tumorsB M Kacinski
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510
Yale J Biol Med 62:379-92. 1989..The authors discuss the role that tumor epithelial cell expression of the fms gene product might play in the auto- and paracrine control of growth and dissemination of ovarian adenocarcinomas...
- Expression of three negative regulators of CYP17 gene transcription in adrenocortical cellsT Lehmann
Department of Biochemistry and Molecular Biology, University of Medical Sciences, Poznan, Poland
Endocr Res 26:1019-26. 2000..Our results suggest that in the adrenocortical cells in culture, the expression of DAX1 and COUP-TF is constitutive, whereas N-CoR expression might be inducible...
- Angiotensin converting enzyme inhibition corrects Na+/H+ exchanger overactivity in essential hypertensionA Fortuno
Vascular Pathophysiology Unit, School of Medicine, University of Navarra, Pamplona, Spain
Am J Hypertens 10:84-93. 1997..This effect appears to be independent of changes in the expression of the mRNA encoding for the NHE-1 isoform of the exchanger...
- The effect of interferon-alpha2b on an in vitro model Dupuytren's contractureJ L Sanders
Department of Surgery, University of Alberta, Edmonton, Canada
J Hand Surg Am 24:578-85. 1999..In Dupuytren's fibroblasts, treatment with IFN-alpha2b significantly down-regulated mRNA expression for cytoplasmic beta-actin and gamma-actin...
- Cytochalasin D-induced actin gene expression in murine erythroleukemia cellsC J Sympson
Department of Biochemistry, University of Louisville School of Medicine, Kentucky 40292
Exp Cell Res 205:225-31. 1993..By contrast, a minimal 99-bp actin promoter-CAT construct containing a functional SRE did not respond to CD...
- The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal beta-actin mRNA translocation in spinal motor neuronsMichael Glinka
Institute for Clinical Neurobiology, Zinklesweg 10, 97078 Wurzburg, Germany
Hum Mol Genet 19:1951-66. 2010..Our data suggest that hnRNP-R-mediated axonal beta-actin mRNA translocation plays an essential physiological role for axon growth and presynaptic differentiation...
- Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotypeReinhold G Erben
Institute of Physiology, Physiological Chemistry and Animal Nutrition, Ludwig Maximilians University, Munich, Germany
J Bone Miner Res 20:1149-60. 2005....
- FRET analysis of actin-myosin interaction in contracting rat aortic smooth muscleJ Black
The Joan C Edwards School of Medicine, Department of Pharmacology, Physiology and Toxicology, Marshall University, Huntington, WV 25704, USA
Can J Physiol Pharmacol 87:327-36. 2009..The results provide direct evidence of dynamic remodeling of the contractile protein during vascular smooth muscle contraction and suggest that FRET analysis may be a powerful tool for assessment of tissue protein-protein associations...
- beta-Actin and GAPDH housekeeping gene expression in asthmatic airways is variable and not suitable for normalising mRNA levelsE M Glare
Department of Respiratory Medicine, Alfred Hospital and Monash University Medical School, Melbourne 3181, Australia
Thorax 57:765-70. 2002..We hypothesised that airway samples which differ in their cellular profiles and activation status have different levels of expression of GAPDH and beta-actin...
- Increased beta-actin and tubulin polymerization in regrowing axons: relationship to the conditioning lesion effectLinda M Lund
VA Medical Cetner 151W, Cleveland, Ohio 44106, USA
Exp Neurol 178:306-12. 2002....
- Crystallization and structure determination of bovine profilin at 2.0 A resolutionE S Cedergren-Zeppezauer
Department of Zoological Cell Biology, Arrhenius Laboratories for Natural Sciences, Stockholm University, Sweden
J Mol Biol 240:459-75. 1994..In forming this cluster, Trp31 adopts a sterically strained rotamer conformation.(ABSTRACT TRUNCATED AT 400 WORDS)..
- Real-time visualization of ZBP1 association with beta-actin mRNA during transcription and localizationYuri Oleynikov
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Curr Biol 13:199-207. 2003..The ZBP1 protein contains four KH RNA binding domains and a classic RBD RNA binding domain. It also contains a putative nuclear import and export sequence, suggesting a nuclear phase in this protein's function...
- Differential distribution of beta- and gamma-actin in guinea-pig cochlear sensory and supporting cellsD N Furness
MacKay Institute of Communication and Neuroscience, School of Life Sciences, Keele University, Staffordshire ST5 5BG, United Kingdom
Hear Res 207:22-34. 2005..Increased expression of beta-actin in outer pillar cells towards the cochlear base may contribute to the greater stiffness of this region...
- cDNA cloning and sequence of a new type of actin in mouse B16 melanomaH Sadano
Department of Experimental Cell Research, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
J Biol Chem 263:15868-71. 1988..These differences between Ax and beta-actin cDNA indicate that the Ax actin is encoded by an unique gene set, independent of beta-actin...
- Tumor necrosis factor-alpha causes barrier dysfunction mediated by tyrosine198 and tyrosine218 in beta-actinNancy Gertzberg
Department of Pharmaceutical Science, Albany College of Pharmacy, Albany, NY 12208, USA
Am J Physiol Lung Cell Mol Physiol 293:L1219-29. 2007..The data indicate that TNF induces an increase in endothelial permeability that is dependent on tyrosine(198) and tyrosine(218) in beta-actin...
- Hypertrophic stimulation increases beta-actin dynamics in adult feline cardiomyocytesSundaravadivel Balasubramanian
Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston, South Carolina, United States of America
PLoS ONE 5:e11470. 2010..These studies demonstrate the presence and dynamics of beta-actin in the adult cardiomyocyte and reinforce its usefulness in measuring cardiac cytoskeletal rearrangement during hypertrophic stimulation...
- High level expression of transfected beta- and gamma-actin genes differentially impacts on myoblast cytoarchitectureG Schevzov
Cell Biology Unit, Children s Medical Research Foundation, Camperdown N S W, Australia
J Cell Biol 117:775-85. 1992..In particular, we conclude that the beta- and gamma-actin genes encode functionally distinct cytoarchitectural information...
- Both beta-actin and GAPDH are useful reference genes for normalization of quantitative RT-PCR in human FFPE tissue samples of prostate cancerRyutaro Mori
Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
Prostate 68:1555-60. 2008..We investigated which housekeeping gene is useful to study gene expression of paraffin embedded human tissue samples of prostate cancer...
- Ion-dependent polymerization differences between mammalian beta- and gamma-nonmuscle actin isoformsSarah E Bergeron
Department of Biochemistry, Roy A and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
J Biol Chem 285:16087-95. 2010..This difference may be particularly important in sites such as the gamma-actin-rich cochlear hair cell stereocilium where local mm calcium concentrations may exist...
- Localization of a beta-actin messenger ribonucleoprotein complex with zipcode-binding protein modulates the density of dendritic filopodia and filopodial synapsesTaesun Eom
Department of Neuroscience, Rose F Kennedy Center for Mental Retardation, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 23:10433-44. 2003..These results reveal a novel function for an mRNA localization element and its binding protein in the regulation of dendritic morphology and synaptic growth via dendritic filopodia...
- Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1Stefan Huttelmaier
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Nature 438:512-5. 2005..These sequential events provide both temporal and spatial control over beta-actin mRNA translation, which is important for cell migration and neurite outgrowth...
- Expression patterns of ubiquitin, heat shock protein 70, alpha-actin and beta-actin over the molt cycle in the abdominal muscle of marine shrimp Litopenaeus vannameiJose Renato O Cesar
Department of Human Nutrition, Food and Animal Sciences, University of Hawaii at Manoa, Honolulu, Hawaii
Mol Reprod Dev 74:554-9. 2007..Muscle structural alpha-actin and cytoskeletal beta-actin were increased during intermolt and premolt stages, suggesting high muscle growth during these stages in the abdominal muscle of the L. vannamei...
- Alzheimer Vaccines: Noninvasive Vaccination by DNA-Base*Ken Ichiro Fukuchi; Fiscal Year: 2005..The nasal membrane application procedure eliminates pain and other problems associated with needle injection, protein purification, and adjuvant modification, and so may reduce medical costs. ..
- Robert H Singer; Fiscal Year: 2015....
- Harish Vasudevan; Fiscal Year: 2015..By studying the interactions between PDGF signaling and SRF activity, we will build the foundation required to design innovative diagnostic and therapeutic strategies targeting these fundamental pathways. ..
- Changwei Liu; Fiscal Year: 2014..Our study might discover a deubiquitinating enzyme as a novel regulator of the SMN complex and thus, identify a novel therapeutic target for SMA. ..
- Regulating retinal microvascular morphogenesisIra M Herman; Fiscal Year: 2010....
- BETA-ACTIN MRNA LOCALIZATIONGARY BASSELL; Fiscal Year: 2002..Using high resolution in situ hybridization and digital imaging microscopy methods, we have shown that beta actin mRNAs were localized to growth cones of developing dendritic and axonal processes...
- MOLECULAR BASIS FOR ETHANOL-INDUCED HYPOTHYROIDISMRobert Zoeller; Fiscal Year: 1993....
- Transgenic Mouse Model for Echovirus PathogenesisVINCENT RACANIELLO; Fiscal Year: 2004..Establishment of a small animal model may yield information about echovirus pathogenesis that could stimulate development of echovirus vaccines or antiviral drugs. ..
- ROLES OF MICROFILAMENT PROTEINS IN NEOPLASIA/METASTASISJohn Leavitt; Fiscal Year: 1993....
- METALS EFFECT ON HEME METABOLISMMAHIN MAINES; Fiscal Year: 1999..4) To investigate the role of HO isozymes in regulation in vivo and in vitro synthesis of NO and production of cGMP. ..
- DEMYELINATION IN MULTIPLE SCLEROSISMOON SHIN; Fiscal Year: 1999..Specifically, the role of C1 activation directly by myelin in vivo following breakdown of blood brain barrier will be examined as well as the role of TCC in inflammatory demyelination. ..
- Anti-Viral Gene Delivery in the Nervous SystemDaniel Carr; Fiscal Year: 2005..abstract_text> ..
- Mammary Tumor Stem CellsAnne Peaston; Fiscal Year: 2009..Extending the use of fluorescently marked PI-MEC to multiple mouse mammary tumor models will be important to understand the general extent to which this cell population contributes to different types of mammary cancer. ..
- PROCESSING OF EUKARYOTIC MESSENGER RNAMary Edmonds; Fiscal Year: 1990..If specific proteins are identified, their binding to the oligo U(+) mRNA population would be tested and ultimately binding to an oligo U containing mRNA such as beta-actin would be tested...
- Caveolin-1 and Cyclin D1 in Mammary TumorigenesisRichard Pestell; Fiscal Year: 2006..3). Determine if genetic ablation of the caveolin- 1 gene predisposes towards mammary tumorigenesis and metastasis in vivo. ..
- Effects of HMG-coA Reductase Pathway Inhibitors on GCADWilliam Stein; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- MECHANISM IN DOPAMINE RECEPTOR SENSITIVITY REGULATIONJEANNETTE MILLER; Fiscal Year: 1990....
- mRNA transport and local translation after axotomyDianna Willis; Fiscal Year: 2007..I will focus these analyses on axonal mRNAs encoding structural proteins (Beta-actin, peripherin and vimentin) and injury-response proteins (HSP70, grp78/BiP and Importin Beta1) that play central roles in axonal growth. ..
- MECHANISMS OF REGULATION OF CELL PROLIFERATIONMichael Getz; Fiscal Year: 1993....
- Spatial and temporal control of the mouse genome by lacHeidi Scrable; Fiscal Year: 2005..Moreover, use of the lac system to regulate Hdh and Arc will allow us to explore the hypothesis that these genes play essential roles during synaptogenesis and in synaptic plasticity and spermatogenesis in the adult (aim 3) ..
- MPTP-Induced Homing of Bone Marrow Stem Cells to the Br*Lee Anna Cunningham; Fiscal Year: 2003..If successful, these studies may provide the basis for future work to development new non-invasive gene therapies for Parkinson's disease, using accessible, renewable and autologous bone marrow stem cells. ..
- Neuronal mRNA transport & local translation analysisJeffery Twiss; Fiscal Year: 2004..g., spinal motor neurons) and whether we can utilize exogenous agents to increase local axonal protein synthesis for expediting axonal regeneration. ..
- ROLE OF METASCHEMATIN PROTEINS IN NEOPLASIACHINGSHWUN LIN; Fiscal Year: 1991..Finally, we will study the synergistic effect of metaschematin, plastin, and mutant beta-actin expression on the induction of the neoplastic phenotype in diploid human fibroblasts...
- Zebrafish Hair Cell Machines at Molecular ResolutionManfred Auer; Fiscal Year: 2005..In addition, it will provide important insight into the pathogenesis of cytoplasmic actins and myosin-6-associated deafness. ..
- EF1ALPHA ACTIN IN CELL MOTILITY AND TRANSLATIONJohn Condeelis; Fiscal Year: 2003..mRNAs for beta-actin and Arp3, when localized to the leading edge, determine cell polarity. 2. The EF1a-F-actin complex is the scaffold to which mRNAs, with a beta-actin mRNA-like zipcode, become anchored. ..
- Transgenic Mouse Models for Pathogenesis and TherapyTehsheng Chan; Fiscal Year: 2006..The gene will be introduced under control of the general vector/promoter pCAGGS/chicken beta actin. Animals will be selected on the basis of the presence of the ACE2 gene, levels of protein expression, and early ..
- HIGH-THROUGHPUT SCREEN OF TOPICALLY APPLIED THERAPEUTICSPatrick Hayden; Fiscal Year: 2000..The model will also be adaptable for other basic studies involving modulation of gene messages in skin by chemicals, UV radiation, or other exogenous treatments. ..
- Hippocampal GABAergic Neurons from Progenitor GraftsVittorio Gallo; Fiscal Year: 2006..Altogether, these studies will define a novel experimental paradigm aimed at repairing hippocampal GABAergic intemeuron damage in various pathological states, such as epilepsy, stroke, and ischemia ..
- Evolution of Promoter Activity in Conserved GenesGLENN MASTON; Fiscal Year: 2005....
- MOLECULAR MECHANISMS WHEREBY CTG EXPANSION RESULTS IN DMSita Reddy; Fiscal Year: 2004..expanded CTG tracts integrated at random loci in the genome under the transcriptional control of the human beta actin promoter...
- MECHANISMS OF NO-MEDIATED PROTEIN S-NITROSYLATION IN EAEOSCAR BIZZOZERO; Fiscal Year: 2007..abstract_text> ..
- NITRIC OXIDE, PLP ACYLATION & THE PATHOPHYSIOLOGY OF MSOSCAR BIZZOZERO; Fiscal Year: 2003..abstract_text> ..
- Invasion of C. neoformans into brain endothelial cellsAmbrose Jong; Fiscal Year: 2008..The information derived from the studies is expected to be helpful in the development of novel strategies to prevent cryptococcal meningitis and its associated morbidity. ..
- REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANECHRISTOPHER WILCOX; Fiscal Year: 2002....
- Cellular Immunology of Enterovirus InfectionPaul Krogstad; Fiscal Year: 2007..These studies will provide a foundation for further studies of host-pathogen relationships in picornavirus disease and the potential utility of picornaviruses as enterally delivered vaccine vectors. [unreadable] [unreadable] [unreadable]..
- Orthotopic models of tumor angiogenesis and blood flowMeng Yang; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- HIV Replication and Thymopoiesis in AdolescentsPaul Krogstad; Fiscal Year: 2007..unreadable] [unreadable]..
- Mutations in PKA gene transcripts of lupus T cellsDama Laxminarayana; Fiscal Year: 2007..abstract_text> ..
- Individual Promoter SNP and CpG Methylation SignaturesSIMON SPIVACK; Fiscal Year: 2006..abstract_text> ..
- Discovery of novel fluorescent reporter genesMing Zhao; Fiscal Year: 2004..Reporters with spectral properties that can be used for whole-body imaging of tumors in the lung and their metastases will be candidates for further development for numerous applications of multi-color imaging. ..
- Innovative Investigations and Therapies for AsthmaRichard Martin; Fiscal Year: 2007..The ability to predict who will and will not respond to corticosteroids and additive therapy will greatly improve our ability to treat asthma effectively. ..
- Extreme Ammonia Tolerance Mechanisms: A Model VertebratePatrick Walsh; Fiscal Year: 2004..abstract_text> ..
- MAP KINASE SIGNALING IN ASTROGLIAL REACTIONSJames Mandell; Fiscal Year: 2003..3) To generate transgenic mice expressing astrocyte-targeted activators of the ERK/MAPK pathway as critical tests of the working hypothesis. ..
- Restraint stress-induced neurogenic bladder inflammationTheoharis Theoharides; Fiscal Year: 2006..Our findings may be relevant to the pathophysiology of IC and may suggest new therapeutic approaches. ..
- Dual-color tumor-host imaging modelsMeng Yang; Fiscal Year: 2007..These models have significant commercial potential for discovery and development of stroma-targeted and anti-angiogenesis drugs. [unreadable] [unreadable] [unreadable]..
- Conditional Deletion of Dnaic1 as a Model of Primary Ciliary DyskinesiaLAWRENCE OSTROWSKI; Fiscal Year: 2007..If successful, this model will also provide a novel system to investigate other questions concerning pulmonary health and disease. [unreadable] [unreadable] [unreadable]..
- Therapeutic hair follicle-derived neurospheresMeng Yang; Fiscal Year: 2007..Human hair- follicle bulge cells will be further characterized and developed for therapeutic potential for nerve regeneration in Phase III. [unreadable]..
- High density mutagenesis of mtDNAMikhail Alexeyev; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Mechanism of Circadian Susceptibility to PesticidesLOUISA HOOVEN; Fiscal Year: 2008..Humans are inevitably exposed to pyrethroids and other pesticides, and this interdisciplinary investigation is likely to lead to novel strategies protective of human health. [unreadable] [unreadable] [unreadable]..
- A Ciliated Cell-Specific Promoter for Gene Therapy of CFLAWRENCE OSTROWSKI; Fiscal Year: 2005..Specific Aim 3: To demonstrate correction of the CF phenotype in both in vitro and in vivo models by targeted expression of the normal CFTR gene in ciliated cells. ..
- Design and Testing of a Parechovirus Vaccine VectorPaul Krogstad; Fiscal Year: 2005..We propose to construct and complete the initial in vitro testing of a parechovirus based vaccine vector, based on strategies already employed in the successful construction of enteroviral vectors. ..
- Lesion Induced Synaptic PlasticitySTEPHEN GINSBERG; Fiscal Year: 2004....
- Varenicline and Smoking Cessation in SchizophreniaSEYYED HOSSEIN FATEMI; Fiscal Year: 2010..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
- IL-1 Beta influences on NGF in neural DevelopmentANNA JELASO; Fiscal Year: 2003..This work will establish a system for understanding how cytokines and neurotrophins interact during neural development to influence the development and/or maintenance of functional neural circuits. ..
- TRANSGENIC STUDY VASCULAR ROLE OF NEUROPEPTIDE YMichael Michalkiewicz; Fiscal Year: 2002..The NPY overexpressing rats with well defined mutation of the NPY gene will provide a new transgenic animal model of hypertension; such a model should also be very useful for development of new therapies for treating this diseases. ..
- Inhibitors of 5alpha-reductase for acne therapyLingna Li; Fiscal Year: 2002..PROPOSED COMMERCIAL APPLICATIONS: Liposomal 4-MA will be developed as a topical selectively targeted therapeutic for acne for which they should be a very market. ..
- Role of Adenosine Receptors in Mast CellsIgor Feoktistov; Fiscal Year: 2008..Finally, in Specific Aim 4, we will explore the relevance of adenosine receptor subtypes in an in vivo model of chronic pulmonary inflammation. [unreadable] [unreadable]..
- BIOMECHANICAL EFFECT OF ACUPUNCTURE NEEDLINGHELENE LANGEVIN; Fiscal Year: 2001..This will contribute to the fundamental understanding of acupuncture therapy and may lead to improvements in treatments. ..
- Role of Acetaldehyde in Alcoholic CardiomyopathyJun Ren; Fiscal Year: 2008..Our long-term goal is to establish the toxic mechanism of acetaldehyde in the development of alcoholic cardiomyopathy so that prevention and treatment can be optimized [unreadable] [unreadable]..
- Adenoviral GFP targeting of metastatic human tumors using multiple delivery routeHiroyuki Kishimoto; Fiscal Year: 2008..Having obtained these results, we can move forward in the Phase II grant application with experiments to bring OBP-401 to the clinic for use in cancer surgery in human patients. [unreadable] [unreadable] [unreadable]..
- Prenatal Virally Induced Brain Disorder in MouseSEYYED FATEMI; Fiscal Year: 2009..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
- RHOMOCYCSTEINASE FOR HOMOCYSTEINE ASSAYYuying Tan; Fiscal Year: 2002..The tHCY enzymatic kits for these applications will be ready for commercial launch at this point. PROPOSED COMMERCIAL APPLICATION: Not Available ..
- MICROTUBULE/KERATIN INTERACTIONS DURING SPERMATOGENESISABRAHAM KIERSZENBAUM; Fiscal Year: 2002..Engineering mouse models in which the expression of K9 is null, is important for both reproductive biology and cancer research. ..
- Retinal Circadian Signaling in a Transgenic ModelAllan Wiechmann; Fiscal Year: 2004..Discovering the molecular mechanisms of melatonin action may therefore provide a greater understanding of the role of circadian signals in environmentally- and genetically- induced photoreceptor degenerations. ..
- Prostate Cancer: A Mouse Model Testing 15-Lipoxygenase-1Uddhav Kelavkar; Fiscal Year: 2004..abstract_text> ..
- Soft Tissue Biomechanical Behavior During Acupuncture in Low Back PainHelene M Langevin; Fiscal Year: 2010....
- Arsenic Embryotoxocity: Cellular and Molecular TargetsM Pisano; Fiscal Year: 2003....
- Enzyme therapy for hyperhomocysteinemiaYuying Tan; Fiscal Year: 2005..Phase II results will lead to an IND for MEGC-PEG-rMETase for end stage renal disease patients and other patients with intractable hyperhomocysteinemia and high cardiovascular disease mortality. ..
- Arp2/3 mRNA localization and directional cell migrationGang Liu; Fiscal Year: 2008..unreadable] [unreadable]..
- The Role of Adenosine Receptors in Endothelial CellsIgor Feoktistov; Fiscal Year: 2005..Our preliminary results also suggest that hypoxia modulates A2B receptor expression, a hypothesis that will be explored in Specific Aim IV. These experiments may lead to a novel approach for the treatment of pathologic angiogenesis. ..
- Regulation of Cx43 by Src and Novel Interacting ProteinsAlan Lau; Fiscal Year: 2009....
- CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL ATheoharis Theoharides; Fiscal Year: 2001..They may also help explain some key events in the pathophysiology of migraines, the clinical symptoms of which are often precipitated by stress. ..
- The Effect of Mycoplasma on Chronic AsthmaRichard Martin; Fiscal Year: 2008..pneumoniae and asthma will be obtained through this PPG and will ultimately give new knowledge to the understanding of asthma pathophysiology and potential future novel therapies. ..
- BIOLOGICAL PROPERTIES OF RPE MELANINJanice M Burke; Fiscal Year: 2010..The effects of age on melanosomes will also be studied to determine whether their ability to protect RPE cells from stress declines over time, which could contribute to diseases of the retina such as age-related macular degeneration. ..
- IDENTIFICATION OF BIOCHEMICAL ABNORMALITIES IN PCD CILIALAWRENCE OSTROWSKI; Fiscal Year: 2002..Further studies of the role of these proteins in the assembly and function of cilia may also result in improved treatment for other air way diseases. ..
- RNA PROCESSING AND RIBONUCLEOPROTEINThoru Pederson; Fiscal Year: 2001..The same studies should provide information on sequences required for nuclear export. These two inter-related projects test the hypothesis that the nucleolus is a more pluri-functional organelle than previously thought. ..
- IGF-1, Oxidative Stress and Cardiovascular AgingJun Ren; Fiscal Year: 2002..Our long-term goal is to establish the causal link among IGF-1 deficiency, enhanced oxidative damage and ventricular dysfunction in the progression of cardiovascular aging so that hormonal or antioxidant therapy can be optimized...
- Hypoglycemic signaling targets in astrocytesJames Mandell; Fiscal Year: 2003..The longterm goal is to develop pharmacologic or molecular methods to augment or modulate neuroprotective aspects of the astrocytic response to hypoglycemia. ..
- Imageable tumor-targeting bacteriaMing Zhao; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- High throughput PCR assays for diagnosing tuberculosisSanjay Tyagi; Fiscal Year: 2007..abstract_text> ..
- Targeted tumoricidal bacteriaMing Zhao; Fiscal Year: 2007..Future human trials of the tumor-killing bacteria can be held after the Phase I and Phase II grant periods are completed. [unreadable] [unreadable] [unreadable]..
- Determinants of Phenotype in Retinal Pigment EpitheliumJanice Burke; Fiscal Year: 2007..To determine whether the anticipated loss of polarity in RPE cells leads to a clinically or morphologically detectable retinal degeneration. ..
- Visualizing the Movement of mRNAs in Living CellsSanjay Tyagi; Fiscal Year: 2007..Through the development of these synergistic techniques, it will be possible to observe the movement of specific mRNAs in living cells. ..
- REGULATION AND FUNCTION OF LUNG SPECIFIC FREAC GENESYe Shih Ho; Fiscal Year: 2002..abstract_text> ..
- ASTHMA CLINICAL RESEARCH NETWORK (ACRN)Richard Martin; Fiscal Year: 2002....
- Protein Biomarker Profiles of Abusive Alcohol ConsumptionFrank Witzmann; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Synaptosomal Protein Changes After EtOH Self-AdministrationFrank Witzmann; Fiscal Year: 2006..unreadable] [unreadable]..
- ASTHMA CHRONOBIOLOGY: CENTRAL AND LUNG INTERACTIONSRichard Martin; Fiscal Year: 2003....
- Molecular Diagnosis Utilizing Cerebrospinal FluidSTEPHEN GINSBERG; Fiscal Year: 2003..abstract_text> ..
- THE PATHOBIOLOGY OF INHERITED RETINAL DEGENERATIONDean Bok; Fiscal Year: 2006..abstract_text> ..
- Mast cells, antidepressants and chronic fatigue syndromeTheoharis Theoharides; Fiscal Year: 2007..Future studies will build on these findings to develop in vitro and in vivo models of CFS and lead to clinical trials with select antidepressants or other molecules that inhibit brain mast cells. [unreadable] [unreadable] [unreadable]..
- RNA Transport Within the NucleusThoru Pederson; Fiscal Year: 2005..Another aspect of the project will address the intranuclear traffic of these RNAs in relation to proteins known to be involved in nuclear import or RNA export, i.e. the Ran-GTPase and TAP. ..
- Functions of ERK and p38 MAP Kinases in AstrogliosisJames Mandell; Fiscal Year: 2008..This approach could promote recovery of brain and spinal cord function after injury or stroke. [unreadable] [unreadable]..
- SHEAR STRESS MODULATION OF ENDOTHELIAL WOUND HEALINGMARIA LUIZA ALBUQUERQUE; Fiscal Year: 2003..Investigation of the mechanisms underlying endothelial repair during shear stress may lead to better strategies for the management of patients suffering from a variety of cardiovascular disorders. ..
- ACTIN BASED MOTILITY BY RICKETTSIA RICKETTSIIROBERT HEINZEN; Fiscal Year: 2002..Not only will these studies lead to a greater understanding of molecular mechanisms of rickettsial pathogenesis, but they will also provide insight into the dynamic control of actin polymerization. ..