BDKRB2

Summary

Gene Symbol: BDKRB2
Description: bradykinin receptor B2
Alias: B2R, BK-2, BK2, BKR2, BRB2, B2 bradykinin receptor, BK-2 receptor
Species: human

Top Publications

  1. ncbi The effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels are dependent on environmental context
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Hum Genet 122:275-81. 2007
  2. doi Kinin B1 and B2 receptor expression in osteoblasts and fibroblasts is enhanced by interleukin-1 and tumour necrosis factor-alpha. Effects dependent on activation of NF-kappaB and MAP kinases
    Anna Bernhold Brechter
    Oral Cell Biology, Umea University, Umea, Sweden
    Bone 43:72-83. 2008
  3. pmc Endogenous bradykinin contributes to increased plasminogen activator inhibitor 1 antigen following hemodialysis
    Annis M Marney
    Division of Diabetes, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6602, USA
    J Am Soc Nephrol 20:2246-52. 2009
  4. ncbi The human bradykinin B2 receptor gene: full length cDNA, genomic organization and identification of the regulatory region
    S Kammerer
    Children s Hospital, Department of Clinical Chemistry and Biochemistry, University of Munich, Germany
    Biochem Biophys Res Commun 211:226-33. 1995
  5. ncbi Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor
    J X Ma
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston 29425
    Genomics 23:362-9. 1994
  6. ncbi Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14
    S J Powell
    Biotechnology Department, ICI Pharmaceuticals, Macclesfield, Cheshire, United Kingdom
    Genomics 15:435-8. 1993
  7. ncbi Expression cloning of a human B1 bradykinin receptor
    J G Menke
    Merck Research Laboratories, Department of Molecular Pharmacology and Biochemistry, Rahway, New Jersey 07065
    J Biol Chem 269:21583-6. 1994
  8. ncbi Genetic variation in the promoter region of the beta2 bradykinin receptor gene is associated with essential hypertension in a Chinese Han population
    B Wang
    Division of Hypertension, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, PR China
    Hypertens Res 24:299-302. 2001
  9. ncbi The genetic factor in acute myocardial infarction with hypertension
    S Aoki
    Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Jpn Circ J 65:621-6. 2001
  10. ncbi Angiotensin-converting enzyme gene insertion/deletion, not bradykinin B2 receptor -58T/C gene polymorphism, associated with angiotensin-converting enzyme inhibitor-related cough in Chinese female patients with non-insulin-dependent diabetes mellitus
    Y J Lee
    Department of Clinical Research, Ping Tung Christian Hospital, Ping Tung, Taiwan, Republic of China
    Metabolism 50:1346-50. 2001

Research Grants

  1. BRADYKININ IN CARDIOVASCULAR DISEASE
    Haralambos Gavras; Fiscal Year: 2006
  2. Bruce L Zuraw; Fiscal Year: 2014
  3. Samir S El-Dahr; Fiscal Year: 2014
  4. CHIH CHANG KEVIN WEI; Fiscal Year: 2014
  5. Innate Immunity in Experimental Arthritis of Kininogen
    Robert Colman; Fiscal Year: 2007
  6. Structure and Function of Carboxypeptidases
    Randal A Skidgel; Fiscal Year: 2013
  7. An Artificial Myocardium for Pediatric Support
    Robert Stewart; Fiscal Year: 2003
  8. ANGIOTENSIN II AND BRADYKININ IN CARDIAC HYPERTROPHY
    LOUIS DELL ITALIA; Fiscal Year: 2007
  9. Histone Deacetylases and Kidney Development
    Samir S El Dahr; Fiscal Year: 2010
  10. PLASMA PROTEIN PHENOTYPING OF PROTHROMBOTIC MICE
    Alvin Schmaier; Fiscal Year: 2003

Detail Information

Publications222 found, 100 shown here

  1. ncbi The effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels are dependent on environmental context
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Hum Genet 122:275-81. 2007
    ..We found strong evidence (P <or= 0.02) for interaction effects of polymorphisms from the bradykinin receptor (BDKRB2) gene and alcohol consumption on t-PA in females and males and on PAI-1 in males...
  2. doi Kinin B1 and B2 receptor expression in osteoblasts and fibroblasts is enhanced by interleukin-1 and tumour necrosis factor-alpha. Effects dependent on activation of NF-kappaB and MAP kinases
    Anna Bernhold Brechter
    Oral Cell Biology, Umea University, Umea, Sweden
    Bone 43:72-83. 2008
    ..These mechanisms might help to explain the enhanced bone resorption associated with inflammatory disorders, including periodontitis and rheumatoid arthritis...
  3. pmc Endogenous bradykinin contributes to increased plasminogen activator inhibitor 1 antigen following hemodialysis
    Annis M Marney
    Division of Diabetes, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6602, USA
    J Am Soc Nephrol 20:2246-52. 2009
    ..Factors that increase the production of bradykinin or decrease its degradation may enhance the inflammatory response to hemodialysis...
  4. ncbi The human bradykinin B2 receptor gene: full length cDNA, genomic organization and identification of the regulatory region
    S Kammerer
    Children s Hospital, Department of Clinical Chemistry and Biochemistry, University of Munich, Germany
    Biochem Biophys Res Commun 211:226-33. 1995
    ..By testing different putative regulatory fragments in a luciferase reporter assay, a gene activating function of the 5' upstream region of exon 1 was demonstrated...
  5. ncbi Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor
    J X Ma
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston 29425
    Genomics 23:362-9. 1994
    The bradykinin B2 receptor (BDKRB2) has high affinity for the intact kinins, which mediate a wide spectrum of biological effects, including pain, inflammation, vasodilation, and smooth muscle contraction and relaxation...
  6. ncbi Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14
    S J Powell
    Biotechnology Department, ICI Pharmaceuticals, Macclesfield, Cheshire, United Kingdom
    Genomics 15:435-8. 1993
    ..The human bradykinin B2 receptor gene has been mapped to chromosome 14 using PCR to specifically amplify DNA from somatic cell hybrids...
  7. ncbi Expression cloning of a human B1 bradykinin receptor
    J G Menke
    Merck Research Laboratories, Department of Molecular Pharmacology and Biochemistry, Rahway, New Jersey 07065
    J Biol Chem 269:21583-6. 1994
    ..The amino acid sequence of the B1 bradykinin receptor is 36% identical to the amino acid sequence of the B2 bradykinin receptor. The cloned B1 bradykinin receptor expressed in mammalian cells exhibits high affinity binding for 3H-..
  8. ncbi Genetic variation in the promoter region of the beta2 bradykinin receptor gene is associated with essential hypertension in a Chinese Han population
    B Wang
    Division of Hypertension, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, PR China
    Hypertens Res 24:299-302. 2001
    ..045) and allelic frequencies (p = 0.033). These results suggested that -58C allele of the human beta2 bradykinin receptor gene may be an independent risk factor for essential hypertension in the Chinese Han population...
  9. ncbi The genetic factor in acute myocardial infarction with hypertension
    S Aoki
    Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Jpn Circ J 65:621-6. 2001
    ..Genetic variations in the AngII and BK-B2 receptors could prove to be significant pathophysiological mechanisms affecting essential hypertension and AMI, and genetic differences appear to be a new risk factor for these conditions...
  10. ncbi Angiotensin-converting enzyme gene insertion/deletion, not bradykinin B2 receptor -58T/C gene polymorphism, associated with angiotensin-converting enzyme inhibitor-related cough in Chinese female patients with non-insulin-dependent diabetes mellitus
    Y J Lee
    Department of Clinical Research, Ping Tung Christian Hospital, Ping Tung, Taiwan, Republic of China
    Metabolism 50:1346-50. 2001
    ..In conclusion, our results indicate that Chinese diabetic female subjects are susceptible to ACEI-related cough, and this susceptibility may be genetically predetermined...
  11. ncbi Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension
    Sukhbir S Dhamrait
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, Rayne Building, London, UK
    Eur Heart J 24:1672-80. 2003
    ..We tested whether these gene variants influenced hypertensive coronary risk in a large prospective study...
  12. ncbi Bradykinin receptor gene variant and human physical performance
    Alun G Williams
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, UK
    J Appl Physiol (1985) 96:938-42. 2004
    ....
  13. ncbi Bradykinin B2 receptor gene C-58T polymorphism and insulin resistance. A study on obese patients
    F Fallo
    Department of Medical and Surgical Sciences, University of Padova, Italy
    Horm Metab Res 36:243-6. 2004
    The bradykinin B2 receptor (B2R) gene is a candidate in the pathogenesis of insulin resistance, which often clusters with other abnormalities in metabolic syndrome...
  14. ncbi Lack of association of a 9 bp insertion/deletion polymorphism within the bradykinin 2 receptor gene with myocardial infarction
    Marcus Fischer
    Clinic for Internal Medicine 2, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Clin Sci (Lond) 107:505-11. 2004
    ..These findings indicate that the 9 bp insertion/deletion polymorphism of the BK B2 receptor gene is neither related to the prevalence of MI nor to left ventricular function after MI...
  15. ncbi Bradykinin B2 receptor gene (-58T/C) polymorphism influences baroreflex sensitivity in never-treated hypertensive patients
    Alberto Milan
    Department of Medicine and Experimental Oncology, Hypertension Unit, University of Torino, Italy
    J Hypertens 23:63-9. 2005
    ..Recent studies suggest that about 40% of baroreflex variation, an index of cardiac autonomic control, is influenced by genetic factors...
  16. ncbi Relationship of bradykinin B2 receptor gene polymorphism with essential hypertension and left ventricular hypertrophy
    Yuxiao Fu
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamada oka, Suita, Japan
    Hypertens Res 27:933-8. 2004
    ..It was recently reported that a polymorphism of the bradykinin B2 receptor gene (BDKRB2) is a genetic predisposing factor for hypertension and cardiovascular disease...
  17. ncbi +9/+9 Homozygosity of the bradykinin receptor gene polymorphism is associated with reduced fat-free mass in chronic obstructive pulmonary disease
    Nicholas S Hopkinson
    Respiratory Muscle Laboratory, Royal Brompton Hospital, Fulham Road, London SW3 6NP, United Kingdom
    Am J Clin Nutr 83:912-7. 2006
    ....
  18. ncbi Dipsogenic genes associated with weight changes during Ironman Triathlons
    Colleen J Saunders
    Medical Research Council of South Africa, MRC UCT Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Newlands 7725, South Africa
    Hum Mol Genet 15:2980-7. 2006
    ..The aim of this study was to determine whether there were any associations between polymorphisms within the ACE, BDKRB2, NOS3 and/or 5-HTT genes with weight changes during the 2000 and 2001 226 km South African Ironman Triathlons...
  19. pmc Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Genomics 89:362-9. 2007
    ..These results support the idea that the interplay between the renin-angiotensin, bradykinin, and fibrinolytic systems might play an important role in t-PA and PAI-1 biology...
  20. ncbi Expression of kinin B1 and B2 receptors in immature, monocyte-derived dendritic cells and bradykinin-mediated increase in intracellular Ca2+ and cell migration
    Cornelia M Bertram
    Lung Institute of Western Australia and Centre for Asthma, Allergy and Respiratory Research, The University of Western Australia, Perth, Australia
    J Leukoc Biol 81:1445-54. 2007
    ..BK, which increases the migration of immature hMo-DC in vitro, may play an important role in the migration of immature DC in noninflammatory conditions and may also be involved in the recruitment of immature DC to sites of inflammation...
  21. ncbi Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression
    Anna Bernhold Brechter
    Umea University, Umea, Sweden
    Arthritis Rheum 56:910-23. 2007
    ....
  22. ncbi The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance
    M M Pretorius
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Clin Pharmacol Ther 83:122-9. 2008
    ..038) or during bradykinin (P=0.03). Increased SBP or vascular resistance may contribute to increased left ventricular mass reported previously in individuals with the BE1+9/+9 genotype...
  23. pmc Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition
    Gary P Van Guilder
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6602, USA
    Hypertension 51:454-9. 2008
    To test the hypothesis that the bradykinin receptor 2 (BDKRB2) BE1+9/-9 polymorphism affects vascular responses to bradykinin, we measured the effect of intra-arterial bradykinin on forearm blood flow and tissue-type plasminogen activator ..
  24. pmc Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential
    Nicolle Krankel
    Experimental Cardiovascular Medicine, Bristol Heart Institute, UK
    Circ Res 103:1335-43. 2008
    ..Reduction of BK sensitivity in progenitor cells from cardiovascular disease patients might contribute to impaired neovascularization after ischemic complications...
  25. pmc Kinin b2 receptor mediates induction of cyclooxygenase-2 and is overexpressed in head and neck squamous cell carcinomas
    Weiping Zhang
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Mol Cancer Res 6:1946-56. 2008
    ..These effects were abolished by the B2 receptor (B2R) antagonist HOE140 but not by the B1 receptor (B1R) antagonist Lys-[Leu(8)]des-Arg(9)-bradykinin...
  26. doi A meta-analysis of the bradykinin B2 receptor gene --58C/T polymorphism with hypertension
    WenQuan Niu
    State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Clin Chim Acta 411:324-8. 2010
    Numerous studies have attempted to associate -58C/T polymorphism of bradykinin B2 receptor gene (BDKRB2) with hypertension, whereas results were often irreproducible...
  27. pmc Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2 receptor antagonism in human synovial fibroblasts
    F Bellucci
    Department of Pharmacology, Menarini Ricerche SpA, Florence, Italy
    Br J Pharmacol 158:1996-2004. 2009
    ..Here, the selective B2 receptor antagonists MEN16132 and icatibant have been pharmacologically characterized in human synovial cells...
  28. doi No association between alleles of the bradykinin receptor-B2 gene and acute mountain sickness
    Pei Wang
    School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
    Exp Biol Med (Maywood) 235:737-40. 2010
    ..the in/del polymorphism +9/-9 [rs5810761] and the single-nucleotide polymorphism C--58T [rs1799722]) of BDKRB2 (the gene encoding the bradykinin receptor B2) and susceptibility to AMS in an altitude-exposed Nepalese ..
  29. doi Association and interaction of -58C>T and ±9 bp polymorphisms of BDKRB2 gene causing susceptibility to essential hypertension
    Charita Bhupatiraju
    Department of Genetics, Osmania University, Hyderabad, India
    Clin Exp Hypertens 34:230-5. 2012
    ..Polymorphisms of bradykinin B2 receptor (BDKRB2) gene are reported to be predisposing factors for hypertension...
  30. pmc Bradykinin B2 receptor-dependent enhancement of enalapril-evoked hypotension in ethanol-fed female rats
    Mahmoud M El-Mas
    Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC 27834, USA
    J Cardiovasc Pharmacol 57:72-8. 2011
    ..interaction between ACE and bradykinin, studies were extended to investigate the role of bradykinin receptor (B2R) in ethanol-enalapril interaction...
  31. ncbi Angiotensin II-induced hypertension in bradykinin B2 receptor knockout mice
    L Cervenka
    Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, 1958 9 Vídeská, 140 00 Prague 4, Czech Republic
    Hypertension 37:967-73. 2001
    ..BK B2receptor knockout (B2R-/-) and wild-type (B2R+/+) mice (22to 26 g) were infused with either saline (SAL) or Ang II (40ng/min) via an ..
  32. ncbi Renal protective role of bradykinin B1 receptor in stroke-prone spontaneously hypertensive rats
    Makoto Hagiwara
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Hypertens Res 27:399-408. 2004
    ..Although the bradykinin B2 receptor (B2R) has been reported to be involved in most of these effects, a role of the bradykinin B1 receptor (B1R) has also ..
  33. pmc Bradykinin B2 Receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses
    Ana Carolina Monteiro
    Instituto de Biofisica Carlos Chagas Filho, UFRJ, Rio de Janeiro, Brazil
    PLoS Pathog 3:e185. 2007
    ..kinin-releasing strains of Trypanosoma cruzi through the triggering of G-protein-coupled bradykinin B2 receptors (B2R). Here we report that C57BL/6.B2R-/- mice infected intraperitoneally with T...
  34. ncbi The role of bradykinin B1 receptor on cardiac remodeling in stroke-prone spontaneously hypertensive rats (SHR-SP)
    Norihito Moniwa
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Biol Chem 387:203-9. 2006
    An angiotensin-converting enzyme inhibitor (ACE-I) reduces cardiac remodeling and a bradykinin B2 receptor (B2R) antagonist partially abolishes this ACE-I effect...
  35. doi Aspartic acid scaffold in bradykinin B1 antagonists
    József Huszár
    Department of Medical Chemistry, University of Szeged, Dom ter 8, H 6720, Szeged, Hungary
    J Pept Sci 15:423-34. 2009
    ..None of the four most potent compounds showed significant activity on the bradykinin B2 receptor (B2R), consequently they can be considered as valuable starting points for designing more potent and selective B1 ..
  36. ncbi Signal transduction pathways of G protein-coupled receptors and their cross-talk with receptor tyrosine kinases: lessons from bradykinin signaling
    C Liebmann
    Institute of Biochemistry and Biophysics, Biological and Pharmaceutical Faculty and Research Group, Molecular Cell Biology, Friedrich Schiller University Jena, Germany
    Curr Med Chem 7:911-43. 2000
    ..Firstly, a single class of GPCRs such as the bradykinin type 2 receptor (B2R) may couple to different classes of G proteins in a cell-specific and time-dependent manner, resulting in ..
  37. ncbi Tissue kallikrein and bradykinin B2 receptors in the reproductive tract of the male rat
    T K Monsees
    Centre of Dermatology and Andrology, Justus Liebig University, Giessen, Germany
    Andrologia 35:24-31. 2003
    ..tKKS) within the reproductive organs of the male rat was investigated by analysing bradykinin subtype 2 receptor (B2R) gene expression and cellular distribution of B2R protein and the kinin-liberating protease tissue kallikrein (tK)...
  38. pmc Segmental expression of the bradykinin type 2 receptor in rat efferent ducts and epididymis and its role in the regulation of aquaporin 9
    C Belleannee
    Center for Systems Biology, Program in Membrane Biology Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Reprod 80:134-43. 2009
    ..on epididymal epithelial cells isolated by laser capture microdissection (LCM) showed abundant BK type 2 receptor (Bdkrb2) mRNA expression but no type 1 receptor (Bdkrb1)...
  39. doi Selective tumor blood-brain barrier opening with the kinin B2 receptor agonist [Phe(8)psi(CH(2)NH)Arg(9)]-BK in a F98 glioma rat model: an MRI study
    Jérôme Côté
    Department of Nuclear Medicine and Radiobiology, Universite de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4
    Neuropeptides 44:177-85. 2010
    ..One approach for transporting drugs across the BBB involves the activation of bradykinin-B2 receptors (BK-B2R)...
  40. pmc Bradykinin B2 receptor null mice harboring a Ser23-to-Ala substitution in the p53 gene are protected from renal dysgenesis
    Samir S El-Dahr
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 295:F1404-13. 2008
    A physiological cross talk operates between the tumor suppressor protein p53 and the bradykinin B2 receptor (BdkrB2) during renal organogenesis...
  41. ncbi Cloning, sequence analysis and expression of the gene encoding the mouse bradykinin B2 receptor
    J X Ma
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston 29425
    Gene 149:283-8. 1994
    The bradykinin B2 receptor (B2R) mediates most of the biological effects of kinins. In the present study, we have cloned and sequenced the gene (B2R) from a mouse embryonic stem (ES) cell genomic library...
  42. ncbi Employing Rhodobacter sphaeroides to functionally express and purify human G protein-coupled receptors
    Ankita Roy
    Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Max von Laue Strasse 3, D 60438 Frankfurt Main, Germany
    Biol Chem 389:69-78. 2008
    ..adenosine A2a receptor (A2aR), the human angiotensin AT1a receptor (AT1aR) and the human bradykinin B2 receptor (B2R). Several different constructs were examined and functional production of the recombinant receptors was achieved...
  43. pmc Ontogeny of bradykinin B1 receptors in the mouse kidney
    Ozlem Pinar Bulut
    Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Pediatr Res 66:519-23. 2009
    Kinins are vasoactive peptides that stimulate two G-protein coupled bradykinin receptors (B1R and B2R). B2R-knockout mice are salt sensitive and develop renal dysgenesis and hypertension if salt stressed during embryogenesis...
  44. ncbi Combinatorial control of the bradykinin B2 receptor promoter by p53, CREB, KLF-4, and CBP: implications for terminal nephron differentiation
    Zubaida Saifudeen
    Department of Pediatrics, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, Louisiana 70112, USA
    Am J Physiol Renal Physiol 288:F899-909. 2005
    ..The bradykinin B2 receptor (B2R) regulates renal function and integrity, and its expression is induced during terminal nephron differentiation...
  45. ncbi The Bradykinin B2 receptor gene is a target of angiotensin II type 1 receptor signaling
    Bing Shen
    Department of Pediatrics, SL 37, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Am Soc Nephrol 18:1140-9. 2007
    ..It was demonstrated that the bradykinin B2 receptor gene (BdkrB2) is a direct transcriptional target of the angiotensin II (AngII) type 1 receptor (AT(1)R) in collecting duct ..
  46. ncbi Angiotensin II type 2 receptor-bradykinin B2 receptor functional heterodimerization
    Peter M Abadir
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia, Charlottesville, VA, USA
    Hypertension 48:316-22. 2006
    Angiotensin II type 2 (AT2R) or bradykinin B2 (B2R) receptor activation enhances NO production. Recently, we demonstrated enhancement of NO production when AT2R and B2R are simultaneously activated in vivo...
  47. doi Expression of endogenous nuclear bradykinin B2 receptors mediating signaling in immediate early gene activation
    Martin Savard
    Department of Pharmacology, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Cell Physiol 216:234-44. 2008
    ..Some evidence has suggested, however, the existence of an intracellular/nuclear B2R population. Whether these receptors are functional and contribute to BK signaling remains to be determined...
  48. doi The angiotensin II type 1 receptor antagonist Losartan binds and activates bradykinin B2 receptor signaling
    Marie Mi Bonde
    Laboratory for Molecular Cardiology, The Danish National Research Foundation Centre for Cardiac Arrhythmia, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Juliane Mariesvej 20, section 9312, DK 2100 Copenhagen, Denmark
    Regul Pept 167:21-5. 2011
    ..and some of the cardioprotective effects of Losartan are abolished by blocking the bradykinin B2 receptor (B2R) signaling...
  49. ncbi Effects of two novel non-peptide antagonists at the rabbit bradykinin B2 receptor
    F Marceau
    Centre Hospitalier Universitaire de Quebec, Centre de recherche du Pavillon l Hôtel Dieu de Québec, G1R 2J6, Quebec, Canada
    Peptides 22:1397-402. 2001
    ..contractility of the jugular vein, competition of [3H]BK binding to a B2 receptor-green fluorescent protein (B2R-GFP) conjugate, subcellular distribution of B2R-GFP)...
  50. ncbi Spatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expression
    Zubaida Saifudeen
    Department of Pediatrics, Section of Pediatric Nephrology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 280:23094-102. 2005
    ..TAp73 also activated the bradykinin B2 receptor (B2R) promoter, a developmentally regulated gene involved in regulation of sodium excretion...
  51. doi Angiotensin-converting enzyme limits inflammation elicited by Trypanosoma cruzi cysteine proteases: a peripheral mechanism regulating adaptive immunity via the innate kinin pathway
    Julio Scharfstein
    Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, 21949 900 Rio de Janeiro, Brazil
    Biol Chem 389:1015-24. 2008
    ..endogenous danger signal that induces dendritic cell (DC) maturation via G protein-coupled bradykinin B2 receptors (B2R)...
  52. ncbi Bradykinin enhances reactive oxygen species generation, mitochondrial injury, and cell death induced by ATP depletion--a role of the phospholipase C-Ca(2+) pathway
    Wen Chih Chiang
    Department of Internal Medicine, National Taiwan University Hospital, No 7, Jhongshan S Rd, Taipei 10016, Taiwan
    Free Radic Biol Med 43:702-10. 2007
    ..All these effects were reversed by coadministration with bradykinin B2 receptor (B2R) antagonist...
  53. ncbi Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1)
    D R Bachvarov
    Centre de recherche Université Laval, Hotel Dieu de Quebec, Quebec, Quebec, G1R 2J6, Canada
    Genomics 33:374-81. 1996
    Two subtypes of mammalian bradykinin receptors, B1 and B2 (BDKRB1 and BDKRB2), have been defined based on their pharmacological properties...
  54. doi Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema
    Madeleine Austinat
    Department of Neurology, Julius Maximilians University of Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Stroke 40:285-93. 2009
    ..The effects of kinins are mediated by 2 different receptors (B1 and B2 receptor [B1R and B2R]) and comprise induction of edema formation and release of proinflammatory mediators.
  55. ncbi [Effects of human tissue kallikrein 1 gene delivery on carotid artery neointima formation after balloon angioplasty in spontaneously hypertensive rats]
    Hui zhen Yu
    Hypertension Institution Research of Fujian, First Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China
    Zhonghua Xin Xue Guan Bing Za Zhi 38:67-71. 2010
    ..To investigate the effects of human tissue kallikrein 1(Ad-hKLK1) gene delivery on the neointima formation in carotid arteries of spontaneously hypertensive rats (SHRs)...
  56. doi Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking
    Kerstin Göbel
    Department of Neurology, University of Wuerzburg, Josef Schneider Strasse 11, 97080 Wuerzburg, Germany
    J Autoimmun 36:106-14. 2011
    ..They increase vascular permeability and enhance inflammation by acting on distinct bradykinin receptors, B1R and B2R. We studied the expression of B1R and B2R and the effect of their inhibition on the disease course, BBB integrity ..
  57. ncbi The human B1 bradykinin receptor exhibits high ligand-independent, constitutive activity. Roles of residues in the fourth intracellular and third transmembrane domains
    L M Leeb-Lundberg
    Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 276:8785-92. 2001
    ..activity occurred when the fourth intracellular C-terminal domain (IC-IV) of the human B2 BK receptor subtype (B2R), which exhibits minimal constitutive activity, was substituted in either B1R or B1A(121) to make B1(B2ICIV) and B1(..
  58. pmc Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice
    Masao Kakoki
    Department of Pathology and Laboratory Medicine and Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 107:10190-5. 2010
    ..We have therefore explored the influence of lack of both bradykinin receptors (B1R and B2R) on diabetic nephropathy, neuropathy, and osteopathy in male mice heterozygous for the Akita diabetogenic mutation ..
  59. doi Selective covalent labeling of tag-fused GPCR proteins on live cell surface with a synthetic probe for their functional analysis
    Hiroshi Nonaka
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo ku, Kyoto 615 8510, Japan
    J Am Chem Soc 132:9301-9. 2010
    ..The covalent labeling of tag-fused GPCRs such as bradykinin receptor (B2R) and acetylcholine receptor (m1AchR) selectively proceeded under physiological conditions during short incubation (..
  60. ncbi Localization of B1 bradykinin receptor mRNA in the primate brain and spinal cord: an in situ hybridization study
    Paul J Shughrue
    Department of Neuroscience, Merck Research Laboratories, Sumneytown Pike and Broad Street, WP26A 3000, West Point, PA 19486, USA
    J Comp Neurol 465:372-84. 2003
    The bradykinin 1 and 2 receptors (B1R, B2R) are important mediators of cardiovascular homeostasis, inflammation, and nociception...
  61. doi The cardiovascular influence of interleukin-1 beta on the expression of bradykinin B1 and B2 receptors
    A Riad
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Department of Cardiology and Pneumology, Germany
    Int Immunopharmacol 8:222-30. 2008
    The cytokine interleukin 1ss (IL-1ss) and the bradykinin receptors 1 (B1R) and 2 (B2R) are known to be upregulated in the ischemic heart. In the present study we investigated whether or not there is a causal link between these entities...
  62. ncbi Induction of B1 receptors in streptozotocin diabetic rats: possible involvement in the control of hyperglycemia-induced glomerular Erk 1 and 2 phosphorylation
    Marilyne Mage
    INSERMU388, Institut Louis Bugnard, CHU Rangueil, Toulouse, France
    Can J Physiol Pharmacol 80:328-33. 2002
    ..a 3-week treatment with various combinations of angiotensin-converting enzyme inhibitor (ACEI) and B1 and B2 bradykinin receptor (B1R and B2R) antagonists (B1A and B2A) and AT1 receptor antagonist on ERK 1 and 2 phosphorylation in ..
  63. ncbi Inhibition of sequestration of human B2 bradykinin receptor by phenylarsine oxide or sucrose allows determination of a receptor affinity shift and ligand dissociation in intact cells
    Alexander Faussner
    Ludwig Maximilians Universitat Munchen, Abteilung für Klinische Chemie und Klinische Biochemie, Nussbaumstrasse 20, D 80336 MUnchen, Germany
    Biol Chem 385:835-43. 2004
    ..When sequestration of the B2 bradykinin receptor (B2R) was inhibited by either 0...
  64. doi Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment
    Monica Gratacos
    CIBER en Epidemiología y Salud Pública CIBERESP, Instituto de Salud Carlos III, Madrid, Spain
    Am J Med Genet B Neuropsychiatr Genet 150:808-16. 2009
    ..Remarkably, a functional SNP, rs945032, located in the promoter region of the bradykinin receptor B2 gene (BDKRB2) was associated to three disorders (panic disorder, substance abuse, and bipolar disorder), and two additional ..
  65. ncbi [Pain and Bradykinin Receptors--sensory transduction mechanism in the nociceptor terminals and expression change of bradykinin receptors in inflamed condition]
    Kazue Mizumura
    Department of Neural Regulation, Research Institute of Environmental Medicine, Nagoya University, Nagoya, 464 8601, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 25:33-8. 2005
    ..In addition nociceptor sensitivity to BK was augmented in inflamed animals, with B2R mRNA and protein upregulated...
  66. pmc Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure
    Marcin Zakrzewski-Jakubiak
    Universite de Montreal, Montreal, Canada
    Br J Clin Pharmacol 65:742-51. 2008
    ..It is also acknowledged that the genotype frequency of certain gene polymorphisms varies across different ethnic groups and that a difference in gene polymorphism frequencies between healthy and heart failure patients seems to exist...
  67. ncbi Bradykinin metabolism pathway in the rat pulmonary circulation
    J B Pesquero
    Department of Biophysics, Escola Paulista de Medicina, Sao Paulo, Brazil
    J Hypertens 10:1471-8. 1992
    ..The contribution made by different enzymes to the degradation of bradykinin in physiological conditions was estimated by examining bradykinin metabolism in rat serum, in the in situ perfused lung and in vivo...
  68. pmc Maize Brittle stalk2 encodes a COBRA-like protein expressed in early organ development but required for tissue flexibility at maturity
    Anoop Sindhu
    Department of Botany and Plant Pathology, Purdue University, West Lafayette, Indiana 47907 2054, USA
    Plant Physiol 145:1444-59. 2007
    The maize (Zea mays) brittle stalk2 (bk2) is a recessive mutant, the aerial parts of which are easily broken. The bk2 phenotype is developmentally regulated and appears 4 weeks after planting, at about the fifth-leaf stage...
  69. ncbi Regulation of cardiac bradykinin B1- and B2-receptor mRNA in experimental ischemic, diabetic, and pressure-overload-induced cardiomyopathy
    Frank Spillmann
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, D 12220 Berlin, Germany
    Int Immunopharmacol 2:1823-32. 2002
    ..We have therefore investigated the bradykinin B1-receptor (B1R) and B2-receptor (B2R) mRNA expression in rat models of MI, LVH and diabetes mellitus (DM)...
  70. ncbi Xanthomonas campestris pv. campestris requires a functional pigB for epiphytic survival and host infection
    A R Poplawsky
    Department of Plant, Soil and Entomological Sciences, University of Idaho, Moscow 83844 2339, USA
    Mol Plant Microbe Interact 11:466-75. 1998
    ..parent strain B-24, Tn3HoHo1 pigB insertion mutation strain B24-B2, chromosomally restored pigB mutation strain B24-B2R, and strain B24-79 with a Tn3HoHo1 insertion in an unrelated part of the genome were compared for epiphytic ..
  71. ncbi [High molecular weight kininogen in inflammation and angiogenesis: a review of its properties and therapeutic applications]
    Irma Isordia-Salas
    The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Rev Invest Clin 57:802-13. 2005
    ..Furthermore, it has been shown that a bradykinin 2 receptor (B2R) antagonist attenuates the inflammatory changes in the same animal model...
  72. ncbi Influence of bradykinin B1 and B2 receptors in the immune response triggered by renal ischemia-reperfusion injury
    Pamella Huey Mei Wang
    Laboratório de Imunologia Clínica e Experimental Division of Nephrology Universidade Federal de São Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil
    Int Immunopharmacol 6:1960-5. 2006
    ..This study was aimed to analyze the involvement of bradykinin B1 and B2 receptors (B1R and B2R) in tissue response after renal ischemia-reperfusion injury...
  73. pmc Bradykinin [corrected] B1 receptor antagonism is beneficial in renal ischemia-reperfusion injury
    Pamella H M Wang
    Laboratório de Imunologia Clínica e Experimental, Division of Nephrology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 3:e3050. 2008
    ..Herein, B1R antagonism (R-954) was able to decrease serum creatinine levels, whereas B2R antagonism had no effect...
  74. ncbi Chimeric molecules between keratinocyte growth factor and basic fibroblast growth factor define domains that confer receptor binding specificities
    R Reich-Slotky
    Department of Biology, Technion Israel Institute of Technology, Haifa, Israel
    J Biol Chem 270:29813-8. 1995
    ..The chimeras are designated BK1 (bFGF1-54:KGF91-194), BK2 (bFGF1-74:KGF111-194), KB1 (KGF31-90:bFGF55-155), and KB2 (KGF31-110:bFGF75-155)...
  75. ncbi Overexpression of bradykinin type 2 receptors on glioma cells enhances bradykinin-mediated blood-brain tumor barrier permeability increase
    Mikito Uchida
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, 8631 West Third Street, Suite 800E, Los Angeles, CA 90048, USA
    Neurol Res 24:739-46. 2002
    Variations in the expression levels of bradykinin (BK) type 2 receptors (B2R) in different brain tumors may explain variable increases in BK-mediated blood-brain tumor barrier (BTB) permeability...
  76. ncbi B2R of bradykinin activated by proteases
    Peter A Deddish
    Hypertension 42:e1-2; author reply e1-2. 2003
  77. ncbi Multiple myeloma in a murine syngeneic model:modulation of growth and angiogenesis by a monoclonal antibody to kininogen
    Irma M Sainz
    The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, USA
    Cancer Immunol Immunother 55:797-807. 2006
    ..factor-2 (FGF-2), vascular endothelial growth factor (VEGF), bradykinin-1 receptor (B1R), bradykinin-2 receptor (B2R) and HK...
  78. ncbi Autoradiographic analysis of mouse brain kinin B1 and B2 receptors after closed head trauma and ability of Anatibant mesylate to cross the blood-brain barrier
    Brice Ongali
    Departement de Physiologie, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada
    J Neurotrauma 23:696-707. 2006
    ..In the present study, alteration of kinin B1 and B2R after closed head trauma (CHT) and in vivo binding properties of Anatibant Ms (3 mg/kg, s.c...
  79. ncbi Early activation of bradykinin B2 receptor aggravates reactive oxygen species generation and renal damage in ischemia/reperfusion injury
    Wen Chih Chiang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei 10016, Taiwan
    Free Radic Biol Med 41:1304-14. 2006
    ..effects of kallikrein on ischemia/reperfusion injury were reversed by cotreatment with bradykinin B2 receptor (B2R) antagonist, but not B1 receptor antagonist, and were not associated with hemodynamic changes...
  80. doi Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain
    Shenglan Wang
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Brain 131:1241-51. 2008
    ..evoked by allyl isothiocyanate (AITC) or cinnamaldehyde in HEK293 cells expressing TRPA1 and bradykinin receptor 2 (B2R)...
  81. pmc Simvastatin reverses cardiac hypertrophy caused by disruption of the bradykinin 2 receptor
    Juan C Osorio
    Columbia University, New York, NY, USA
    Can J Physiol Pharmacol 86:633-42. 2008
    Bradykinin 2 receptor (B2R) deficiency predisposes to cardiac hypertrophy and hypertension. The pathways mediating these effects are not known...
  82. doi Theoretical study of the human bradykinin-bradykinin B2 receptor complex
    Artur Gieldon
    Johann Wolfgang Goethe Universitat, Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Frankfurt Germany
    Chembiochem 9:2487-97. 2008
    The interaction of bradykinin (BK) with the bradykinin B2 receptor (B2R) was analyzed by using molecular modeling (MM) and molecular dynamics (MD) simulations...
  83. doi Effects of angiotensin-1 converting enzyme inhibition on oxidative stress and bradykinin receptor expression during doxorubicin-induced cardiomyopathy in rats
    Carole Richard
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, IFR 100, Facultés de Médecine et Pharmacie, Dijon Cedex, France
    J Cardiovasc Pharmacol 52:278-85. 2008
    ..Myocardial MCP-1 expression was higher in the D group. Cardiac kinin receptor (B1R and B2R) expression was not affected by D, yet binding sites for B2R and B1R were increased in D+P and P groups, ..
  84. doi Deletion of bradykinin B1 receptor reduces renal fibrosis
    Pamella Huey Mei Wang
    Laboratório de Imunologia Clínica e Experimental, Division of Nephrology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Int Immunopharmacol 9:653-7. 2009
    The Kallikrein-kinin system works through activation of two receptors. One constitutive, named B2 receptor (B2R) and another inducible, denominated B1 receptor (B1R)...
  85. doi The bradykinin B2 receptor mediates hypoxia/reoxygenation induced neuronal cell apoptosis through the ERK1/2 pathway
    Min Tang
    Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China
    Neurosci Lett 450:40-4. 2009
    The bradykinin B2 receptor (B2R) mediates many physiological processes such as hypotension, inflammation and blood-vessel permeability. Hypoxia/reoxygenation (H/R) induces neuronal cell apoptosis...
  86. doi Age-related changes in kallikreins-kinins system in rat corpus cavernosum
    T Wang
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Int J Androl 34:33-40. 2011
    ..Tissue kallikrein-I (KLKI) and kinin B2 receptor (B2R) mRNA in CC and thoracic aorta were detected by real-time polymerase chain reaction (PCR)...
  87. doi Endogenous vasoactive peptides and the human vagina--a molecular biology and functional study
    Harrina E Rahardjo
    Department of Urology and Urological Oncology, Division of Surgery, Hannover Medical School, Hannover, Germany
    J Sex Med 8:35-43. 2011
    ..While the effects of endogenous peptides on the human male erectile tissue have already been described, only very few studies have been conducted to investigate the peptidergic control of female genital tissues, including the vagina...
  88. doi Pharmacogenetic predictors of angiotensin-converting enzyme inhibitor-induced cough: the role of ACE, ABO, and BDKRB2 genes
    Sergi Mas
    Department of Anatomic Pathology, University of Barcelona, Spain
    Pharmacogenet Genomics 21:531-8. 2011
    ..of the variability of the genes involved in bradykinin metabolism (ACE and XPNPEP2) and bradykinin receptors (BDKRB2)...
  89. doi Bradykinin inhibits high glucose- and growth factor-induced collagen synthesis in mesangial cells through the B2-kinin receptor
    Nelly Blaes
    INSERM U1048, Institut des Maladies Métaboliques et Cardiovasculaires I2MC, Universite Paul Sabatier, Toulouse cedex France
    Am J Physiol Renal Physiol 303:F293-303. 2012
    ..is achieved with angiotensin I-converting enzyme inhibitors (ACEI), which also favor bradykinin (BK) B2 receptor (B2R) activation...
  90. doi Pharmacological modulation of the bradykinin-induced differentiation of human lung fibroblasts: effects of budesonide and formoterol
    Federica Sabatini
    Pulmonary Disease Unit, G Gaslini Institute, Genoa, Italy
    J Asthma 49:1004-11. 2012
    ....
  91. pmc Administration of angiotensin II and a bradykinin B2 receptor blocker in midpregnancy impairs gestational outcome in guinea pigs
    Gloria Valdes
    Centro de Investigaciones Medicas, Escuela de Medicina, Pontificia Universidad Catolica, Santiago, Chile
    Reprod Biol Endocrinol 12:49. 2014
    ..as counter-regulators, circulating angiotensin II (AII) was exogenously elevated and the bradykinin B2 receptor (B2R) was antagonized in pregnant guinea-pigs...
  92. pmc Genome-wide analysis of gestational gene-environment interactions in the developing kidney
    Lei Yan
    Section of Pediatric Nephrology, Department of Pediatrics, and the Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, Louisiana and
    Physiol Genomics 46:655-70. 2014
    The G protein-coupled bradykinin B2 receptor (Bdkrb2) plays an important role in regulation of blood pressure under conditions of excess salt intake...
  93. doi Rupatadine effectively prevents the histamine-induced up regulation of histamine H1R and bradykinin B2R receptor gene expression in the rat paw
    Dimitra Molyva
    1st Department of Pharmacology, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece Electronic address
    Pharmacol Rep 66:952-5. 2014
    ..Both types of bradykinin receptors (B1R and B2R) are also known to contribute significantly to the latter and some sort of functional interaction between them and ..
  94. doi The landscape of copy number variations in Finnish families with autism spectrum disorders
    Chakravarthi Kanduri
    Department of Medical Genetics, University of Helsinki, P O Box 63, 00014, Helsinki, Finland
    Autism Res 9:9-16. 2016
    ..2, 15q13.2-q13.3, 17q12, and 22q11.21. Additionally, several novel candidate genes (BDKRB1, BDKRB2, AP2M1, SPTA1, PTH1R, CYP2E1, PLCD3, F2RL1, UQCRC2, LILRB3, RPS9, and COL11A2) were identified through gene ..
  95. doi Novel signaling of dynorphin at κ-opioid receptor/bradykinin B2 receptor heterodimers
    Bingyuan Ji
    School of Life Science, Shandong Agricultural University, Taian 271018, PR China Neurobiology Institute, Jining Medical University, Jining 272067, PR China
    Cell Signal . 2017
    The κ-opioid receptor (KOR) and bradykinin B2 receptor (B2R) are involved in a variety of important physiological processes and share many similar characteristics in terms of their distribution and functions in the nervous system...
  96. ncbi Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells
    V Soskic
    Institute of Molecular Biotechnology e V, 07745 Jena, Germany
    J Biol Chem 274:8539-45. 1999
    ....
  97. ncbi The Bradykinin B2 receptor is required for full expression of renal COX-2 and renin
    John D Imig
    Department of Physiology, Medical College of Georgia, Vascular Biology Center, Augusta, GA 30912 2500, USA
    Peptides 24:1141-7. 2003
    ..To test this hypothesis, we examined the impact of bradykinin B2 receptor (B2R) gene disruption in mice on kidney COX-2 and renin gene expression...
  98. ncbi Immunolocalization and expression of kinin B1R and B2R receptors in human inflammatory bowel disease
    Antoni Stadnicki
    Department of Internal Medicine, Medical University of Silesia, Katowice, Poland
    Am J Physiol Gastrointest Liver Physiol 289:G361-6. 2005
    ..Thus bradykinin receptors in IBD may reflect intestinal inflammation. Increased B(1)R gene and protein expression in active IBD provides a structural basis of the important role of bradykinin in chronic inflammation...
  99. ncbi Activated EGF receptor may balance ERK-inhibitory network signalling pathways
    Sabine Hanke
    Institute of Biochemistry and Biophysics, Biological and Pharmaceutical Faculty, Friedrich Schiller University, Philosophenweg 12, D 07743 Jena, Germany
    Cell Signal 18:1031-40. 2006
    ..In contrast, co-stimulation of either beta2-AR or B2R with EGFR leads to synergistic activation of ERK...
  100. ncbi Angiotensin II type 2 receptor expression after vascular injury: differing effects of angiotensin-converting enzyme inhibition and angiotensin receptor blockade
    Thomas A Barker
    Cardiovascular Research Institute, University of Rochester, Rochester, NY, USA
    Hypertension 48:942-9. 2006
    ..valsartan and the ACE inhibitor benazepril require AT2R signaling through the bradykinin 1 and 2 receptors (B1R and B2R)...
  101. ncbi Inhibition of human and rabbit arterial smooth muscle cell migration mediated by the kinin B1 receptor: role of receptor density and released mediators
    Guillaume Morissette
    Centre de Recherche en Rhumatologie et Immunologie T1 49, Centre Hospitalier Universitaire de Quebec, 2705 Boulevard Laurier, Quebec, QC G1V 4G2, Canada
    Can J Physiol Pharmacol 84:1107-19. 2006
    ..The effect of the B1R agonist on motility was abrogated by a B1R antagonist, B-9858, but not by the B2R antagonist Hoe 140; a peptidase-resistant B2R agonist, [Phe8Psi(CH2-NH)-Arg9]BK, had a marginal or no effect on ..

Research Grants13

  1. BRADYKININ IN CARDIOVASCULAR DISEASE
    Haralambos Gavras; Fiscal Year: 2006
    The purpose of this application is to continue studies on the role of each of the two bradykinin receptors, B1R and B2R, in cardiovascular diseases...
  2. Bruce L Zuraw; Fiscal Year: 2014
    ..actions in both experimental animals and human asthmatic subjects, mice lacking the bradykinin B2 receptor (B2R) exhibit enhanced bronchial hyperresponsiveness, inflammation, and airway remodeling in the OVA model of allergic ..
  3. Samir S El-Dahr; Fiscal Year: 2014
    ..We previously demonstrated that bradykinin B2 receptor-null (BdkrB2-/-) embryos exposed to gestational salt stress develop renal dysgenesis as a result of p53-mediated apoptosis of ..
  4. CHIH CHANG KEVIN WEI; Fiscal Year: 2014
    ..BK through activation of the kallikrein/kinin system and BK2 receptor prevents fibrosis and decreases blood pressure in cardiovascular and renal disease (3)...
  5. Innate Immunity in Experimental Arthritis of Kininogen
    Robert Colman; Fiscal Year: 2007
    ..We will examine the role of HKa and bradykinin using knockouts of their binding proteins, uPAR and B2R, in murine arthritis and systemic inflammation...
  6. Structure and Function of Carboxypeptidases
    Randal A Skidgel; Fiscal Year: 2013
    ..disruption of CPM/B1R interaction will attenuate B1R-mediated endothelial barrier damage in response to B2R agonist. We will determine: (i) G-protein coupling mediated by CPM interaction with the B1R vs. agonist binding...
  7. An Artificial Myocardium for Pediatric Support
    Robert Stewart; Fiscal Year: 2003
    ..device will be for temporary use either to allow myocardial healing and/or recovery (so-called bridge-to-recovery (B2R)), or to provide adequate blood flow in patients suffering from irreversible heart failure while awaiting heart ..
  8. ANGIOTENSIN II AND BRADYKININ IN CARDIAC HYPERTROPHY
    LOUIS DELL ITALIA; Fiscal Year: 2007
    ..ECM degradation persisted and ISF BK (10) and LV BK2 and LV fibroblast AT2 receptor expression were increased during VO...
  9. Histone Deacetylases and Kidney Development
    Samir S El Dahr; Fiscal Year: 2010
    ..Thus, understanding the epigenetic regulation of kidney development may open new avenues to the treatment or prevention of kidney and urinary tract malformations and kidney failure. ..
  10. PLASMA PROTEIN PHENOTYPING OF PROTHROMBOTIC MICE
    Alvin Schmaier; Fiscal Year: 2003
    ..These studies could serve as a basis for the development of a global assay(s) to predict the prothrombotic state in man. (End of Abstract.) ..
  11. Activation of Bradykinin B2 Receptor by Kallikrein
    ERVIN ERDOS; Fiscal Year: 2005
    ..Receptor activation will be assessed by measuring arachidonic acid release, ..
  12. Thrombostatin-A Thrombin Receptor Inhibitor
    Alvin Schmaier; Fiscal Year: 2006
    ..Second, the preparation of an IND application for its human use for one indication will be achieved. Thrombostatin(tm) has the opportunity to be a first-in-its-class thrombin receptor activation antagonist. [unreadable] [unreadable]..
  13. Genetic risk factors for Sudden Cardiac Death
    Nona Sotoodehnia; Fiscal Year: 2007
    ....