BAG 3

Summary

Gene Symbol: BAG 3
Description: BCL2 associated athanogene 3
Alias: BAG-3, BIS, CAIR-1, MFM6, BAG family molecular chaperone regulator 3, BCL2-binding athanogene 3, bcl-2-binding protein Bis, docking protein CAIR-1
Species: human

Top Publications

  1. pmc Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2
    Wing Chan
    GSK, Institute of Molecular and Cell Biology, Singapore 138673
    J Biol Chem 284:8185-94. 2009
  2. ncbi Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein
    K Antoku
    Department of Medicine, Department of Pharmacology, University of Pittsburgh, University of Pittsburgh Cancer Institute, BST E1055, 211 Lothrop Street, Pittsburgh, Pennsylvania 15213 2582, USA
    Biochem Biophys Res Commun 286:1003-10. 2001
  3. ncbi An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators
    S Takayama
    The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 274:781-6. 1999
  4. ncbi Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death
    J H Lee
    Department of Medical Genetics, Osaka University Graduate School of Medicine, Japan
    Oncogene 18:6183-90. 1999
  5. ncbi CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70
    H Doong
    Molecular Signaling Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, MD 20892, USA
    Oncogene 19:4385-95. 2000
  6. ncbi The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines
    Q Liao
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    FEBS Lett 503:151-7. 2001
  7. ncbi BAG3 protein controls B-chronic lymphocytic leukaemia cell apoptosis
    M F Romano
    Cell Death Differ 10:383-5. 2003
  8. ncbi CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins
    Howard Doong
    Molecular Signaling Section, Laboratory of Pathology and Regulation of Protein Function Laboratory, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:28490-500. 2003
  9. ncbi Bis induces growth inhibition and differentiation of HL-60 cells via up-regulation of p27
    Yun Jee Seo
    Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 137 701, Korea
    Exp Mol Med 37:624-30. 2005
  10. ncbi CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins
    Jareer N Kassis
    Molecular Signaling Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, 10 Center Drive, MSC 1500, Bethesda, MD 20892 1500, USA
    Exp Cell Res 312:2962-71. 2006

Research Grants

  1. Modulation of Kir Channel Function by Phosphorylation
    Diomedes E Logothetis; Fiscal Year: 2012
  2. JOHN BRANNON GARY; Fiscal Year: 2014
  3. Kenneth D Karlin; Fiscal Year: 2016
  4. Development of Novel Class of Anti-Inflammatory Drugs
    KEN CARTER; Fiscal Year: 2013
  5. Oliver W Press; Fiscal Year: 2016
  6. THOMAS GERARD MINEHAN; Fiscal Year: 2014
  7. MauG-preMADH intermediate structures: Insight into long range electron transfer
    Erik T Yukl; Fiscal Year: 2013
  8. NUR77 Agonists: New Targets for Pancreatic Cancer Chemotherapy
    Stephen H Safe; Fiscal Year: 2011
  9. Yann Schrodi; Fiscal Year: 2016
  10. Development of Protein Surface Binding, Low Entropy Oligomers
    Christian E Schafmeister; Fiscal Year: 2013

Detail Information

Publications308 found, 100 shown here

  1. pmc Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2
    Wing Chan
    GSK, Institute of Molecular and Cell Biology, Singapore 138673
    J Biol Chem 284:8185-94. 2009
    ..These processes are particularly pertinent given the report of genomic amplification of the ACK1 locus in metastatic tumors...
  2. ncbi Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein
    K Antoku
    Department of Medicine, Department of Pharmacology, University of Pittsburgh, University of Pittsburgh Cancer Institute, BST E1055, 211 Lothrop Street, Pittsburgh, Pennsylvania 15213 2582, USA
    Biochem Biophys Res Commun 286:1003-10. 2001
    ....
  3. ncbi An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators
    S Takayama
    The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 274:781-6. 1999
    ..The findings suggest opportunities for specification and diversification of Hsp70/Hsc70 chaperone functions through interactions with various BAG-family proteins...
  4. ncbi Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death
    J H Lee
    Department of Medical Genetics, Osaka University Graduate School of Medicine, Japan
    Oncogene 18:6183-90. 1999
    ..Using a protein interaction cloning procedure, we identified a human gene designated as bis (mapped to chromosome 10q25) that encoded a novel Bcl-2-interacting protein...
  5. ncbi CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70
    H Doong
    Molecular Signaling Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, MD 20892, USA
    Oncogene 19:4385-95. 2000
    ..CAIR-1 sequence is identical, save 2 amino acids, to BAG-3 also cloned recently as Bis, a member of the bcl-2-associated athanogene family...
  6. ncbi The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines
    Q Liao
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    FEBS Lett 503:151-7. 2001
    Pancreatic cancer cells are usually resistant to apoptosis mediated by intrinsic or extrinsic factors. BAG-3 (Bis, CAIR), which was identified as a BAG-1-related protein, is a novel modulator of cellular anti-apoptotic activity that ..
  7. ncbi BAG3 protein controls B-chronic lymphocytic leukaemia cell apoptosis
    M F Romano
    Cell Death Differ 10:383-5. 2003
  8. ncbi CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins
    Howard Doong
    Molecular Signaling Section, Laboratory of Pathology and Regulation of Protein Function Laboratory, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:28490-500. 2003
    ..Furthermore, poly-ubiquitination is not sufficient for efficient proteasomal targeting of Hsp client proteins...
  9. ncbi Bis induces growth inhibition and differentiation of HL-60 cells via up-regulation of p27
    Yun Jee Seo
    Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 137 701, Korea
    Exp Mol Med 37:624-30. 2005
    b>Bis (Bag-3, CAIR), a Bcl-2-interacting protein, promotes the anti-apoptotic activity of Bcl-2 and increased levels of Bis have been observed in several disease models...
  10. ncbi CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins
    Jareer N Kassis
    Molecular Signaling Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, 10 Center Drive, MSC 1500, Bethesda, MD 20892 1500, USA
    Exp Cell Res 312:2962-71. 2006
    ..These results collectively indicate that CAIR-1 may negatively regulate adhesion, focal adhesion assembly, signaling, and migration via its PXXP domain...
  11. ncbi The antiapoptotic protein BAG3 is expressed in thyroid carcinomas and modulates apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand
    Gennaro Chiappetta
    Dipartimento di Scienze Farmaceutiche DIFARMA, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, Italy
    J Clin Endocrinol Metab 92:1159-63. 2007
    ..We previously showed that BAG3 protein, a member of the BAG (Bcl-2-associated athanogene) co-chaperone family, modulates apoptosis in human leukemias. The expression of BAG3 in other tumor types has not been extensively investigated so far...
  12. pmc Evidence for BAG3 modulation of HIV-1 gene transcription
    Alessandra Rosati
    Department of Pharmaceutical Sciences DiFarma, University of Salerno, Salerno, Italy
    J Cell Physiol 210:676-83. 2007
    ..These observations reveal a previously unrecognized cell response, that is, an increase in BAG3, elicited by HIV-1 infection, and may provide a new avenue for the suppression of HIV-1 gene expression...
  13. ncbi BAG3 regulates motility and adhesion of epithelial cancer cells
    Masahiro Iwasaki
    Medical College of Georgia, Augusta, Georgia, USA
    Cancer Res 67:10252-9. 2007
    ..Thus, the high levels of BAG3 protein seen in some epithelial cancer cell lines may be relevant to mechanisms of tumor invasion and metastasis...
  14. ncbi Transcriptional upregulation of BAG3 upon proteasome inhibition
    Hua Qin Wang
    Department of Biochemistry and Molecular Biology, China Medical University, Shenyang 110001, China
    Biochem Biophys Res Commun 365:381-5. 2008
    ..Taken together, our results suggest that BAG3 induction might represents as an unwanted molecular consequence of utilizing proteasome inhibitors to combat tumors...
  15. ncbi HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy
    Serena Carra
    Centre de Recherche en Cancérologie and Département de Médecine, Universite Laval, Quebec, Canada
    J Biol Chem 283:1437-44. 2008
    ..We conclude that the HspB8 activity is intrinsically dependent on Bag3, a protein that may facilitate the disposal of doomed proteins by stimulating macroautophagy...
  16. pmc Mutation in BAG3 causes severe dominant childhood muscular dystrophy
    Duygu Selcen
    Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic, Rochester, NY, USA
    Ann Neurol 65:83-9. 2009
    ..Bag3, another Z-disk-associated protein, has antiapoptotic properties, and its targeted deletion in mice causes fulminant myopathy with early lethality. We therefore searched for mutations in BAG3 in 53 unrelated MFM patients...
  17. doi BAG3 gene silencing sensitizes leukemic cells to Bortezomib-induced apoptosis
    Peng Liu
    Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, People s Republic of China
    FEBS Lett 583:401-6. 2009
    ..Our results indicate that knocking down BAG3 gene is a promising new approach to enhance the therapeutic potency of Bortezomib in leukemia...
  18. pmc Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
    Martin Gamerdinger
    Department of Pathobiochemistry, Institute for Physiological Chemistry and Pathobiochemistry, Medical School, Johannes Gutenberg University, Mainz, Germany
    EMBO J 28:889-901. 2009
    ....
  19. doi Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction
    Margit Fuchs
    Centre de Recherche, L Hôtel Dieu de Québec, 9 rue McMahon, Quebec, G1R 2J6, Canada
    Biochem J 425:245-55. 2009
    ....
  20. doi The co-chaperone BAG3 interacts with the cytosolic chaperonin CCT: new hints for actin folding
    Bianca Fontanella
    Department of Pharmaceutical Sciences, Division of Biomedicine Arturo Leone, University of Salerno, Salerno, Italy
    Int J Biochem Cell Biol 42:641-50. 2010
    ..To our knowledge, this is the first report showing a biologically relevant interaction between the chaperonin CCT and BAG3 protein, thus suggesting interesting involvement in the folding processes regulated by CCT...
  21. doi Chaperone-assisted selective autophagy is essential for muscle maintenance
    Verena Arndt
    Institute for Cell Biology and Bonner Forum Biomedizin, University of Bonn, Ulrich Haberland Strasse 61a, D 53121 Bonn, Germany
    Curr Biol 20:143-8. 2010
    ....
  22. pmc IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth
    Massimo Ammirante
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Cancer Center, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0723, USA
    Proc Natl Acad Sci U S A 107:7497-502. 2010
    ..As a proof of principle, we show that treatment of a mouse xenograft tumor model with bag3siRNA-adenovirus that down-regulates bag3 results in reduced tumor growth and increased animal survival...
  23. doi BAG3 protein delocalisation in prostate carcinoma
    Stefania Staibano
    Department of Biomorphological and Functional Sciences, Pathology Section, University Federico II of Naples, School of Medicine, Via S Pansini, 5, 80131, Naples, Italy
    Tumour Biol 31:461-9. 2010
    ..These results indicate that BAG3 intra-cytoplasmic delocalisation is a specific feature of cancer versus non-neoplastic prostate and a candidate new marker for prediction of prostate cancer invasiveness and behaviour...
  24. pmc Inheritance patterns and phenotypic features of myofibrillar myopathy associated with a BAG3 mutation
    Zagaa Odgerel
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 9404, USA
    Neuromuscul Disord 20:438-42. 2010
    ..The study underlines the importance of parental evaluation as it may have implications for genetic counseling...
  25. pmc BAG3 directly associates with guanine nucleotide exchange factor of Rap1, PDZGEF2, and regulates cell adhesion
    Masahiro Iwasaki
    Medical College of Georgia, 1210 Laney Walker Street, Augusta, GA 92023, USA
    Biochem Biophys Res Commun 400:413-8. 2010
    ....
  26. pmc BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress
    Akinori Hishiya
    Boston Biomedical Research Institute, Watertown, MA 02472, USA
    Circ Res 107:1220-31. 2010
    ..However, the detailed disease mechanism is not yet fully understood...
  27. pmc BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins
    Martin Gamerdinger
    Institute of Pathobiochemistry, University Medical Center, Johannes Gutenberg University, Duesbergweg 6, Mainz 55099, Germany
    EMBO Rep 12:149-56. 2011
    ..Notably, aggresome-targeting by BAG3 is distinct from previously described mechanisms, as it does not depend on substrate ubiquitination...
  28. doi BAG3 (BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells
    Miwa Suzuki
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Cancer Lett 303:65-71. 2011
    ..The incidence of BAG3 positivity was significantly higher at advanced clinical stages of ovarian cancer than at early stages. We suggest that BAG3 binds to MMP2 to positively regulate the process of cell invasion...
  29. doi BAG3-related myofibrillar myopathy in a Chinese family
    H C Lee
    Department of Pathology, Princess Margaret Hospital, Hong Kong, China
    Clin Genet 81:394-8. 2012
    ..772C>T. Muscle biopsy findings were suggestive of myofibrillar myopathy on light microscopy and ultrastructural studies. To our knowledge, this is the first Chinese case of Bag3opathy so far reported...
  30. pmc BAG3 directly interacts with mutated alphaB-crystallin to suppress its aggregation and toxicity
    Akinori Hishiya
    Cardiovascular Group, Boston Biomedical Research Institute, Watertown, Massachusetts, United States of America
    PLoS ONE 6:e16828. 2011
    ..Our findings indicate a novel function for BAG3 in inhibiting protein aggregation caused by the genetic mutation of CRYAB responsible for human myofibrillar myopathy...
  31. pmc A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy
    Eric Villard
    INSERM U956, Paris 75013, France
    Eur Heart J 32:1065-76. 2011
    ..So far, the genetics of DCM remains largely unresolved. We conducted the first genome-wide association study (GWAS) to identify loci contributing to sporadic DCM...
  32. pmc BAG3: a multifaceted protein that regulates major cell pathways
    A Rosati
    Department of Pharmaceutical and Biomedical Sciences FARMABIOMED, University of Salerno, Fisciano, Italy
    Cell Death Dis 2:e141. 2011
    ..This review attempts to outline the emerging mechanisms that can underlie some of the biological activities of the protein, focusing on implications in tumor progression...
  33. pmc BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy
    Michelina Festa
    Department of Pharmaceutical and Biomedical Sciences FARMABIOMED, University of Salerno, Fisciano, Salerno, Italy
    Am J Pathol 178:2504-12. 2011
    ..Our data identify BAG3 as a potential marker of glial brain tumor sensitivity to therapy and thus also an attractive candidate for new molecular therapies...
  34. doi The HSPB8-BAG3 chaperone complex is upregulated in astrocytes in the human brain affected by protein aggregation diseases
    K Seidel
    Department of Pathology and Medical Biology, University Medical Centre Groningen, Groningen, The Netherlands
    Neuropathol Appl Neurobiol 38:39-53. 2012
    ....
  35. doi Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes
    Takuro Arimura
    Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Hum Mutat 32:1481-91. 2011
    ..These observations suggested that BAG3 mutations present in 2.8% of Japanese familial DCM patients caused DCM possibly by interfering with Z-disc assembly and inducing apoptotic cell death under the metabolic stress...
  36. doi Bag3 promotes resistance to apoptosis through Bcl-2 family members in non-small cell lung cancer
    Yong Zhang
    Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi an 710038, PR China
    Oncol Rep 27:109-13. 2012
    ..We conclude that NSCLC cells were protected from apoptosis through increasing Bag3 expression and consequently promoted the expression of Bcl-XL and Bcl-2...
  37. doi BAG3 down-modulation reduces anaplastic thyroid tumor growth by enhancing proteasome-mediated degradation of BRAF protein
    Gennaro Chiappetta
    Functional Genomic Unit, National Cancer Institute, Fondazione G Pascale, Via M Semmola, 80131 Naples, Italy
    J Clin Endocrinol Metab 97:E115-20. 2012
    ..Anaplastic thyroid tumors (ATC) express high levels of BAG3, a member of the BAG family of cochaperone proteins that is involved in regulating cell apoptosis through multiple mechanisms...
  38. doi BAG3 controls angiogenesis through regulation of ERK phosphorylation
    A Falco
    Department of Pharmaceutical and Biomedical Sciences FARMABIOMED, University of Salerno, Fisciano, Italy
    Oncogene 31:5153-61. 2012
    ....
  39. doi Expression of the antiapoptotic protein BAG3 is a feature of pancreatic adenocarcinoma and its overexpression is associated with poorer survival
    Alessandra Rosati
    Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Fisciano, Italy
    Am J Pathol 181:1524-9. 2012
    ..Our results indicate that BAG3 has a relevant role in PDAC biology, and suggest that BAG3 expression level might be a potential marker for prediction of patient outcome...
  40. doi PKCδ-mediated phosphorylation of BAG3 at Ser187 site induces epithelial-mesenchymal transition and enhances invasiveness in thyroid cancer FRO cells
    N Li
    1 Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, China 2 Key Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China
    Oncogene 32:4539-48. 2013
    ..Collectively, the current study indicates that BAG3 is a novel substrate of PKCδ, and PKCδ-mediated phosphorylation of BAG3 is implicated in EMT and invasiveness of thyroid cancer cells. ..
  41. pmc The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737
    Mariana Boiani
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 288:6980-90. 2013
    ..These studies identify BAG3-mediated Mcl-1 stabilization as a potential target for cancer drug discovery...
  42. doi Bag-3 expression is involved in pathogenesis and progression of colorectal carcinomas
    Xue Yang
    Department of Biochemistry and Molecular Biology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang, China
    Histol Histopathol 28:1147-56. 2013
    ..05). Our study indicated that aberrant Bag-3 expression might be involved in colorectal adenoma-adenocarcinoma sequence and subsequent progression...
  43. doi BAG3 sensitizes cancer cells exposed to DNA damaging agents via direct interaction with GRP78
    De Hui Kong
    Department of Biochemistry and Molecular Biology, China Medical University, Shenyang 110001, China Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang 110001, China Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110001, China
    Biochim Biophys Acta 1833:3245-53. 2013
    ..Overall, these results suggested that through direct interaction BAG3 could prevent the antiapoptotic effect of GRP78 upon genotoxic stress. ..
  44. pmc Down-modulation of Bis reduces the invasive ability of glioma cells induced by TPA, through NF-κB mediated activation of MMP-9
    Young Dae Lee
    Department of Biochemistry, Cancer Research Institute, Cancer Evolution Research Center, College of Medicine, The Catholic University of Korea, Seoul 137 701, Korea
    BMB Rep 47:262-7. 2014
    Bcl-2 interacting cell death suppressor (Bis) has been shown to have anti-apoptotic and anti-stress functions. Recently, increased Bis expression was reported to correlate with glioma aggressiveness...
  45. doi BAG3 regulates epithelial-mesenchymal transition and angiogenesis in human hepatocellular carcinoma
    Heng Xiao
    1 Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China 2 Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Hangzhou, China
    Lab Invest 94:252-61. 2014
    ..In conclusion, BAG3 is associated with the invasiveness and angiogenesis in HCC, and the BAG3 gene may be a novel therapeutic approach against HCC. ..
  46. pmc Knockdown of BAG3 induces epithelial-mesenchymal transition in thyroid cancer cells through ZEB1 activation
    X Meng
    1 Department of Biochemistry and Molecular Biology, China Medical University, Shenyang 110001, China 2 Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110001, China
    Cell Death Dis 5:e1092. 2014
    ..These results indicate BAG3 as a regulator of ZEB1 expression in EMT and as a regulator of metastasis in thyroid cancer cells, providing potential targets to prevent and/or treat thyroid cancer cell invasion and metastasis. ..
  47. doi Bag3 gene expression is regulated by heat shock factor 1
    Silvia Franceschelli
    Department of Pharmaceutical Sciences DiFarma, University of Salerno, Salerno, Italy
    J Cell Physiol 215:575-7. 2008
    ..Because of the anti-apoptotic role of BAG3 protein, these results disclose a previously unrecognized pathway, through which HSF1 maintains cell survival...
  48. doi Activation of BAG3 by Egr-1 in response to FGF-2 in neuroblastoma cells
    A Gentilella
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, P19122, USA
    Oncogene 27:5011-8. 2008
    ..These observations suggest a new role for BAG3 in regulation of the cell cycle...
  49. pmc BAG3 protein regulates caspase-3 activation in HIV-1-infected human primary microglial cells
    Alessandra Rosati
    Department of Pharmaceutical Sciences DiFarma, University of Salerno, Salerno, Italy
    J Cell Physiol 218:264-7. 2009
    ..This is the first reported evidence of a role for BAG3 in the balance of death versus survival during viral infection...
  50. pmc Autoregulation of co-chaperone BAG3 gene transcription
    Antonio Gentilella
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, Pennsylvania 19122, USA
    J Cell Biochem 108:1117-24. 2009
    ..These observations suggest that BAG3 gene expression is controlled by its own product and that this may be critical for the biological activity of BAG3 in some cell types...
  51. doi Characterization of BAG3 cleavage during apoptosis of pancreatic cancer cells
    Hua Qin Wang
    Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, China
    J Cell Physiol 224:94-100. 2010
    ..This novel regulation of BAG3 may have important implications for its role in apoptosis...
  52. doi Co-chaperone BAG3 and adenovirus penton base protein partnership
    E Gout
    Institut de Biologie Structurale, 41 rue Jules Horowitz, CEA, CNRS, Universite Joseph Fourier, 38027 Grenoble, France
    J Cell Biochem 111:699-708. 2010
    ..In addition, these data enrich our knowledge about the multifunctionality of the BAG3 co-chaperone...
  53. pmc BAG3 expression in glioblastoma cells promotes accumulation of ubiquitinated clients in an Hsp70-dependent manner
    Antonio Gentilella
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 286:9205-15. 2011
    ..These observations provide the first evidence for an involvement of BAG3 in the ubiquitination and turnover of its partners...
  54. pmc Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy
    Nadine Norton
    Cardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136 1015, USA
    Am J Hum Genet 88:273-82. 2011
    ..Knockdown of bag3 in a zebrafish model recapitulated DCM and heart failure. We conclude that new comprehensive genomic approaches have identified rare variants in BAG3 as causative of DCM...
  55. doi Involvement of JNK and NF-κB pathways in lipopolysaccharide (LPS)-induced BAG3 expression in human monocytic cells
    Hua Qin Wang
    Department of Biochemistry and Molecular Biology, China Medical University, Shenyang 110001, China
    Exp Cell Res 318:16-24. 2012
    ..Overall, the data support that BAG3 is induced by LPS via JNK and NF-κB-dependent signals, and involved in monocytic cell-extracellular matrix interaction, suggesting that BAG3 may have a role in the host response to LPS stimulation...
  56. ncbi Regulation by heavy metals and temperature of the human BAG-3 gene, a modulator of Hsp70 activity
    Maria Gabriella Pagliuca
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Fisciano, Italy
    FEBS Lett 541:11-5. 2003
    ..The role of BAG-3 protein during apoptosis and cellular stress is discussed...
  57. ncbi Oxidative injury induces influx-dependent changes in intracellular calcium homeostasis
    J D Swann
    Department of Pathology, School of Medicine, University of Maryland, Baltimore 21201
    Toxicol Pathol 19:128-37. 1991
    ..Experiments with Ca(2+)-free medium containing ethylene glycol-bis(beta-aminoethyl ether)N,N,N',N'-tetraacetic acid (EGTA) showed that the increase of [Ca2+]i was due to influx from ..
  58. ncbi Effects of erythropoietin on endothelin-1 synthesis and the cellular calcium messenger system in vascular endothelial cells
    V Vogel
    Renal Section, Medical Polyclinic and Institute of Physiology I, University of Bonn, Germany
    Am J Hypertens 10:289-96. 1997
    ..Cytotoxicity was assessed by sodium 3'-[1-(phenyl-amino-carbonyl)-3,4-tetrazolium]-bis(4-methoxy-6-nitro)ben zene sulfonic acid hydrate (XTT) assay...
  59. ncbi Indirect immunohistochemistry and immunoelectron microscopy distribution of eight epidermal-dermal junction epitopes in the pig and in isolated perfused skin treated with bis (2-chloroethyl) sulfide
    N A Monteiro Riviere
    Cutaneous Pharmacology and Toxicology Center, North Carolina State University, Raleigh 27606, USA
    Toxicol Pathol 23:313-25. 1995
    Sulfur mustard (bis [2-chloroethyl] sulfide, HD) is a potent cutaneous vesicant that causes gross blisters by separation of the epidermal-dermal junction (EDJ)...
  60. ncbi Carcinogenic activity of the flame retardant, 2,2-bis(bromomethyl)-1,3-propanediol in rodents, and comparison with the carcinogenicity of other NTP brominated chemicals
    J K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 25:541-8. 1997
    ..multisite-multispecies carcinogens in laboratory animals, and in this paper we report that the flame retardant, 2,2-bis(bromomethyl)-1,3-propanediol (BMP) is also a multisite carcinogen in both sexes of Fischer 344 rats and B6C3F1 mice...
  61. ncbi Carcinogen induced unscheduled DNA synthesis in mouse hepatocytes
    J E Klaunig
    Department of Pathology, Medical College of Ohio, Toledo 43699, USA
    Toxicol Pathol 12:119-25. 1984
    ..2-AAF), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), benzo(a)pyrene (BP), dimethylbenzanthracene (DMBA), 1,1,-bis(p-chlorophenyl)-2,2,2-trichloroethane (DDT), safrole, diethylstilbestrol (DES), aflatoxin B1 (AFB1), and dieldrin ..
  62. pmc Muscarinic regulation of cytosolic free calcium in canine tracheal smooth muscle cells: Ca2+ requirement for phospholipase C activation
    C M Yang
    Department of Pharmacology, Chang Gung Medical College, Tao Yuan, Taiwan
    Br J Pharmacol 110:1239-47. 1993
    ..carbachol to TSMCs that had been prelabelled with [3H]-inositol led to the rapid (5-15 s) release of inositol mono, bis and trisphosphates IP1, IP2 and IP3...
  63. ncbi [Effects of hydroxyl radicals on purified angiotensin I converting enzyme]
    B Michel
    Institut de Pharmacologie, , , Strasbourg
    Arch Mal Coeur Vaiss 91:1013-9. 1998
    ..OH) on purified ACE. .OH were produced using a generator: 2,2'-azo-bis 2-amidinopropane (GRH) provided by Lara-Spiral (Fr)...
  64. pmc Delayed depolarization and slow sodium currents in cutaneous afferents
    O Honmou
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510
    J Neurophysiol 71:1627-37. 1994
    ..and spike burst activity induced by 4-AP in SN was present in Ca(2+)-free solutions containing 1 mM ethylene glycol-bis (beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid and was not blocked by Cd2+ (1.0 mM). 6...
  65. ncbi Combined ion-pair extraction and gas chromatography-mass spectrometry for the simultaneous determination of diamines, polyamines and aromatic amines in Port wine and grape juice
    J O Fernandes
    , , Universidade do Porto, Portugal
    J Chromatogr A 886:183-95. 2000
    ..Sample clean-up consisted of the extraction of the amines with the ion-pairing reagent bis-2-ethylhexylphosphate dissolved in chloroform followed by a back-extraction with 0.1 M HCl...
  66. ncbi [Specific treatment of the acute cerebral infarct. Present and future]
    J J Muñoz-Torrero
    Servicio de Neurologia, Unidad de Ictus, Hospital Universitario La Paz, Universidad Autonoma de Madrid, Madrid, Espana
    Rev Neurol 31:959-82. 2000
    ..Others have used heparinoids (TOAST) or low molecular weight heparins (FISS or FISS bis) with no benefit either but with excessive bleeding with the former...
  67. pmc Effects of 8-bromoguanosine 3':5'-cyclic monophosphate on phenylephrine-induced phosphatidylinositol hydrolysis and contraction in rat caudal artery
    S A Lum Min
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Br J Pharmacol 116:1697-703. 1995
    ..Similarly, removal of extracellular Ca2+ (2 mM ethylene glycol-bis(beta-amino-ethyl ether) N, N, N', N'-tetraacetic acid (EGTA)) blocked phenylephrine-induced PI hydrolysis, but did ..
  68. pmc Transfer of DDT used in malaria control to infants via breast milk
    H Bouwman
    Department of Zoology, University for Christian Higher Education, Potchefstroom, South Africa
    Bull World Health Organ 70:241-50. 1992
    The transfer of p,p'-DDT (1,1,1-tricholoro-2,2-bis(4-chlorophenyl)ethane) and its metabolites to infants via breast-feeding was studied in an area of KwaZulu, South Africa, where DDT is used to interrupt malaria transmission...
  69. ncbi Immunoglobulin G-dependent classical complement pathway activation in neutrophil-mediated cytotoxicity to infective larvae of Angiostrongylus cantonensis
    M F Shaio
    Department of Parasitology and Tropical Medicine, National Defense Medical Centre, Taipei, Taiwan, Republic of China
    Ann Trop Med Parasitol 84:185-91. 1990
    ..or treated with zymosan, but they were markedly decreased when immune serum was treated with Mg2(+)-ethylene glycol-bis-(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid...
  70. pmc Angiotensin-converting enzyme (ACE) inhibitor transport in human intestinal epithelial (Caco-2) cells
    D T Thwaites
    Department of Physiological Sciences, University of Newcastle upon Tyne, Medical School
    Br J Pharmacol 114:981-6. 1995
    ..4. Experiments with BCECF[2',7',-bis(2-carboxyethyl)-5(6)-carboxyfluorescein]-loaded Caco-2 cells demonstrate that dipeptide transport across the apical ..
  71. pmc Inhibition of volume-activated chloride currents in endothelial cells by chromones
    S Heinke
    KU Leuven, Laboratorium voor Fysiologie, Belgium
    Br J Pharmacol 115:1393-8. 1995
    ..At the same membrane potential but in the presence of 100 microM sodium cromoglycate (disodium-1,3-bis (2'-carboxylate-chromone-5'-yloxy)-2-hydroxy-propane) activation was delayed (253 +/- 25 s, n = 6) and the maximal ..
  72. ncbi Studies on the mechanism by which prolactin stimulates alpha-aminoisobutyric acid uptake into cultured mouse mammary tissues
    K Golden
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan
    Horm Metab Res 25:466-9. 1993
    ..polyamine synthesis appears to be necessary for PRL to effect a stimulation of AIB transport since methylglyoxal bis(guanyl hydrazone), an inhibitor of S-adenosyl methionine decarboxylase, abolishes the PRL response; specificity of ..
  73. ncbi Drug-induced hepatic microgranulomatosis in cynomolgus monkeys
    G M Mesfin
    Upjohn Laboratories, Kalamazoo, Michigan 49007
    Toxicol Pathol 20:7-17. 1992
    ..hepatotoxicity in cynomolgus monkeys treated orally with a novel potassium sparing experimental diuretic, [2,6-bis(4-chlorophenyl)-4-pyridinecarboxylic acid]...
  74. ncbi Quantitation of N epsilon-(dichloroacetyl)-L-lysine in proteins after perchloroethene exposure by gas chromatography-mass spectrometry using chemical ionization and negative ion detection followingimmunoaffinity chromatography
    A Pahler
    Institut fur Toxikologie, Universitat Wurzburg, Germany
    J Chromatogr A 847:25-34. 1999
    ..in blood plasma of human volunteers exposed to PER with a detection limit of 20 fmol for the DCA-Lys derivative 2,2-bis(chlorodifluoromethyl)-4-(1-dichloroacetamido)-butyl- 1,3-oxazolidine-5-one...
  75. ncbi Tumor-promoting effects of both iodine deficiency and iodine excess in the rat thyroid
    J Kanno
    Department of Pathology, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    Toxicol Pathol 20:226-35. 1992
    ..Six-week-old male F344 rats were given a single subcutaneous injection of 2,800 mg/kg body weight N-bis(2-hydroxypropyl)-nitrosamine (DHPN) or saline vehicle, maintained on Remington's iodine-deficient diet (21 +/- 2 ng/..
  76. ncbi Membrane depolarization was required to induce DNA synthesis in murine macrophage cell line PU5-1.8
    S K Kong
    Department of Biochemistry, Chinese University of Hong Kong, Shatin
    Immunopharmacol Immunotoxicol 13:329-39. 1991
    ..8 was investigated with fluorescent probes bis-oxonol and diS-C3-(5). Incubation of PU5-1...
  77. ncbi Antioxidant and prooxidant action of eugenol-related compounds and their cytotoxicity
    Seiichiro Fujisawa
    Department of Oral Diagnosis, Meikai University School of Dentistry, 1 1 Keyakidai, Sakado, Saitama 350 0283, Japan
    Toxicology 177:39-54. 2002
    ..from eugenol (4-allyl-2-methoxyphenol), BHA (2-t-butyl-4-methoxyphenol) or MMP (2-methoxy-4-methylphenol); bis-EUG (3,3'-dimethoxy-5,5'-di-2-propenyl-1, 1'-biphenyl-2,2'-diol) (10), bis-MMP (3,3'-dimethoxy-5,5'-dimethyl-1,1'-..
  78. ncbi The effects of soft segment structure on the fatigue crack propagation of model polyurethanes
    H J Kim
    Department of Material Science and Engineering, University of Tennessee, Knoxville 37966-2200
    Biomed Mater Eng 4:171-85. 1994
    ..The number average molecular weights of the polyethers were within the range of 1000-2000. Methylene bis (4-phenylisocyanate) (MDI) and ethylene diamine were used as the diisocyanate and the chain extender, respectively...
  79. ncbi Determination of ethylenethiourea in food commodities by a two-step derivatization method and gas chromatography with electron-capture and nitrogen-phosphorus detection
    J K Dubey
    Department of Entomology, University of Horticulture and Forestry, Nauni, Solan (HP, India
    J Chromatogr A 765:31-8. 1997
    Ethylenethiourea (ETU) is a decomposition product from ethylene-bis-dithiocarbamates (EBDCs), the most widely used class of fungicides in the world. ETU has been classified as a possible human carcinogen...
  80. ncbi Insulin-like effects on liver Golgi membrane preparations of bis(oxalato)oxovanadate(IV) complex ion, a new vanadate compound
    A M Kordowiak
    Department of Animal Biochemistry, Jagiellonian University, , Poland
    Horm Metab Res 29:101-5. 1997
    ..1), McNeill et al. (2) and Wiliams and Malabu (3), prompted us to investigate a new vanadate complex: disodium bis(oxalato)oxovanadate (IV), Na2[VO(OX)2]H2O...
  81. ncbi Purification of human S-adenosylmethionine decarboxylase expressed in Escherichia coli and use of this protein to investigate the mechanism of inhibition by the irreversible inhibitors, 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine and 5'-([(Z)-4-
    L M Shantz
    Department of Cellular and Molecular Physiology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 17033
    Biochemistry 31:6848-55. 1992
    ..expression vector and purified to apparent homogeneity using affinity chromatography on methylglyoxal bis(guanylhydrazone)-Sepharose...
  82. ncbi Effects of p,p'-DDE on immature cells in culture at concentrations relevant to the Alaskan environment
    J Simonetti
    Department of Biological Sciences/Biomedical Program, University of Alaska Anchorage, 3211 Providence Drive, Anchorage, AK 99508, USA
    Toxicol In Vitro 15:169-79. 2001
    ..All cord blood samples analyzed thus far contain p,p'-DDE (1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene) with an average concentration of 0.33 microg/l...
  83. pmc Effects of tyrosine kinase inhibitors on the contractility of rat mesenteric resistance arteries
    C Toma
    Department of Pharmacology, Aarhus University, Denmark
    Br J Pharmacol 114:1266-72. 1995
    ..The tyrosine kinase substrate-site inhibitor bis-tyrphostin had no inhibitory effect. 3...
  84. ncbi Limitations of N-hydroxysuccinimide esters in affinity chromatography and protein immobilization
    M Wilchek
    Department of Biophysics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Biochemistry 26:2155-61. 1987
    ..In addition to the desired N-hydroxysuccinimide ester, a bis(N-hydroxysuccinimide)derivative of beta-alanine [namely, N- [(succinimidooxy)carbonyl]-beta-alanine N-..
  85. ncbi Effect of heterocyclic analogues of triphenylmethane dyes against Trypanosoma cruzi
    C de Diego
    , Facultad de Farmacia, Universidad Complutense, Madrid, Spain
    Ann Trop Med Parasitol 82:235-41. 1988
    ..Among the compounds tested, the 2-benzothienyl-bis-(4,4'-dimethylaminophenyl) derivative proved to be the most interesting, because of its high selectivity in killing ..
  86. ncbi Detection of bovine whey proteins by on-column derivatization capillary electrophoresis with laser-induced fluorescence monitoring
    I Benito
    , Madrid, Spain
    J Chromatogr A 841:105-14. 1999
    1-Anilinonaphthalene-8-sulfonic acid (1,8-ANS), 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid (bis-ANS) and 2-(p-toluidino)naphthalene-6-sulfonic acid (2,6-TNS) were evaluated as additives in different buffers for the detection of ..
  87. ncbi Chiral separation of amino acids by copper(II) complexes of tetradentate diaminodiamido-type ligands added to the eluent in reversed-phase high-performance liquid chromatography: a ligand exchange mechanism
    G Galaverna
    Dipartimento di Chimica Organica e Industriale, , Italy
    J Chromatogr A 922:151-63. 2001
    ..D,L-amino acids in RP-HPLC by copper(II) complexes of two tetradentate diaminodiamido ligands, (S,S)-N,N'-bis(phenylalanyl)ethanediamine (PheNN-2) and (S,S)-N,N'-bis(methylphenylalanyl)ethanediamine (Me2PheNN-2), added to the ..
  88. ncbi Inhibition of RNA synthesis in vitro by acridines--relation between structure and activity
    M K Piestrzeniewicz
    Department of General Chemistry, , Poland
    Z Naturforsch C 53:359-68. 1998
    ..The acridines (intercalating or non-intercalating and bis-intercalating ligands) assayed here differ in the properties of their complexes with DNA...
  89. ncbi Efficacy of coumermycin, ofloxacin and vancomycin against methicillin-resistant Staphylococcus aureus in vitro and in experimental infections of mice
    A M Hirschl
    Hygiene Institute, University of Vienna, Austria
    Zentralbl Bakteriol Mikrobiol Hyg A 267:541-8. 1988
    In vitro, coumermycin (a bis-hydroxicoumarin gyrase inhibitor) proved significantly more active than ofloxacin and vancomycin against 100 strains of methicillin-resistant Staphylococcus aureus (MRSA). The MIC90 was 0...
  90. pmc Effect of the putative cognitive enhancer, linopirdine (DuP 996), on quantal parameters of acetylcholine release at the frog neuromuscular junction
    S D Provan
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614 0577
    Br J Pharmacol 111:1103-10. 1994
    1. The subcellular mechanism and site of action of linopirdine or DuP 996 (3,3-bis(4-pyridinylmethyl)-1-phenylindolin-2-one) was investigated at the frog neuromuscular junction, using miniature endplate potential (m.e.p.p...
  91. ncbi Adsorption study of alkyl-silicas and methylsiloxy-silicas
    T M Roshchin
    Chemistry Department, Moscow State University, Russia
    J Chromatogr A 931:119-27. 2001
    ..Four adsorbents were prepared and tested: (1) octyl-silica, (2) hexadecyl-silica, (3) bis(trimethylsiloxy)-silica, and (4) oligo(dimethylsiloxane)-silica...
  92. ncbi Occupational allergic contact dermatitis caused by epoxy diacrylate in ultraviolet-light-cured paint, and bisphenol A in dental composite resin
    R Jolanki
    Section of Dermatology, Finnish Institute of Occupational Health, Helsinki, Finland
    Contact Dermatitis 33:94-9. 1995
    ..The other patient was a male process worker in a paint factory. He was sensitized by an epoxy diacrylate, 2,2-bis[4-(2-hydroxy-3-acryloxypropoxy)phenyl]-propane (BIS-GA), and other acrylate compounds contained in raw materials of ..
  93. ncbi Interactions between the gene products of pma1 encoding plasma membrane H(+)-ATPase, and pdr1 controlling multiple drug resistance in Saccharomyces cerevisiae
    S Ułaszewski
    Department of Genetics, Wrocław University, Poland
    Acta Biochim Pol 40:487-96. 1993
    ..Quantitative modifications of cycloheximide and N,N'-(p-xylylidene)-bis-aminoguanidine-2HCl resistance are observed in diploids containing the pma1 and pdr1 genes in trans configuration...
  94. pmc Effect of an intracellular calcium chelator on the regulation of electrically evoked [3H]-noradrenaline release from rat hippocampal slices
    B B Fredholm
    Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Br J Pharmacol 108:126-31. 1993
    ..3H]-NA) release from rat hippocampal slices was reduced by prior treatment of the slices with 1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetomethylester (BAPTA/AM) in a concentration-(10 to 500 microM) dependent ..
  95. ncbi Aromatic amidines: inhibitory effect on purified plasma serine proteinases, blood coagulation and platelet aggregation
    R Ferroni
    Dipartimento di Scienze Farmaceutiche, , Italy
    Farmaco Sci 43:5-13. 1988
    The inhibitory effect of benzamidine as well as of 1,3-di-(p-amidinophenoxy)-2,2-bis-(p-amidinophenoxymethyl)propane (TAPP-H) and TAPP-halo derivatives (with Cl, Br or I) on (i) the catalytic properties of purified plasma serine ..
  96. ncbi Antimalarial activity of Mannich bases derived from 4-(7'-bromo-1',5'-naphthyridin-4'-ylamino)phenol and 4-(7'-trifluoromethylquinolin-4'-ylamino)phenol against Plasmodium falciparum in vitro
    H V Scott
    Army Malaria Research Unit, Milpo, Ingleburn, New South Wales, Australia
    Ann Trop Med Parasitol 81:85-93. 1987
    ..At least one compound, 2,6-bis (piperidin-1''-ylmethyl)-4-(7'-trifluoromethylquinolin -4'-ylamino)phenol (TN112), showed significant superior ..
  97. ncbi In vitro release of SM-11355, cis[((1R,2R)-1,2-cyclohexanediamine-N,N')bis(myristato)] platinum(II) suspended in lipiodol
    S Kishimoto
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Japan
    Biol Pharm Bull 23:637-40. 2000
    SM-11355, cis[((1R,2R)-1,2-cyclohexanediamine-N,N')bis(myristato)] platinum(II) is a lipophilic platinum complex...
  98. ncbi Kainate elicits elevated nuclear calcium signals in retinal neurons via calcium-induced calcium release
    J D Kocsis
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06510
    Brain Res 616:273-82. 1993
    ..CNQX), and greatly reduced by removing Ca2+ from the bath and adding ethylene glycol-bis (beta-amino-ethyl ether) N,N,N',N'-tetraacetic acid (EGTA)...
  99. ncbi Detection of the cyclic nitramine explosives hexahydro-1,3,5-trinitro- 1,3,5-triazine (RDX) and octahydro- 1,3,5,7-tetranitro- 1,3,5,7-tetrazine (HMX) and their degradation products in soil environments
    C A Groom
    Biotechnology Research Institute, National Research Council, Montreal, Quebec, Canada
    J Chromatogr A 909:53-60. 2001
    ..higher humidities and in the presence of anaerobic sludge amendments, consisted of ring cleavage products including bis-(hydroxymethyl)-nitramine and methylenedinitramine...
  100. ncbi Early agonist-induced intracellular acidification is increased in platelets from patients with essential hypertension
    C Lechi
    Istituti di Clinica Medica e di Chimica Clinica, University of Verona, Italy
    Am J Hypertens 7:1090-6. 1994
    ..Intracellular pH was measured with the specific fluorescence indicator 2'7'bis(carboxyethyl)-5,6-carboxyfluorescein...

Research Grants75

  1. Modulation of Kir Channel Function by Phosphorylation
    Diomedes E Logothetis; Fiscal Year: 2012
    ..activity of all Kir channels depends critically on interactions with the membrane phospholipid phosphatidylinositol-bis-phosphate (PIP2)...
  2. JOHN BRANNON GARY; Fiscal Year: 2014
    ..Recent studies have implicated a substrate-binding induced rearrangement to an isomeric bis-m-oxo-dicopper(III) intermediate (O) that performs phenol oxidation with electronic and kinetic isotope parameters ..
  3. Kenneth D Karlin; Fiscal Year: 2016
    ..Also, mixed-valent bis-oxo dicopper complexes will be sought and investigations into the fundamentally important O-O cleavage process will ..
  4. Development of Novel Class of Anti-Inflammatory Drugs
    KEN CARTER; Fiscal Year: 2013
    ..C-Like 2 (LANCL2) as a novel therapeutic target and specifically have found that 61610, a compound of the class of bis(benzimidazoyl)terephthalanilides, exerts potent anti-inflammatory activity in mouse models of IBD...
  5. Oliver W Press; Fiscal Year: 2016
    ..genetically engineered SA mutant molecules with native SA in combination with either biotin or a synthetic divalent bis-biotin targeting molecule in a mouse lymphoma xenograft model...
  6. THOMAS GERARD MINEHAN; Fiscal Year: 2014
    ..In the proposed research, we will prepare a series of mono-, bis-, and tris-C-aryl glucoside derivatives of the gilvocarcin M chromophore and evaluate their association constants ..
  7. MauG-preMADH intermediate structures: Insight into long range electron transfer
    Erik T Yukl; Fiscal Year: 2013
    ..Addition of stoichiometric H2O2 to MauG results in the formation of a catalytically competent bis-Fe(IV) species with one of the hemes in a Fe(IV)=O state while the other is a Fe(IV) species ligated by His and Tyr ..
  8. NUR77 Agonists: New Targets for Pancreatic Cancer Chemotherapy
    Stephen H Safe; Fiscal Year: 2011
    ..The Nur77-active 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes contain CF3 (DIM-C-pPhCF3), H (DIM-C-Ph), and OCH3 (DIM-C-pPhOCH3) ..
  9. Yann Schrodi; Fiscal Year: 2016
    ..is to develop olefin metathesis catalysts based on low-valent molybdenum and iron metals supported by diimine and bis(imino)pyridine ligands...
  10. Development of Protein Surface Binding, Low Entropy Oligomers
    Christian E Schafmeister; Fiscal Year: 2013
    ..with a known bound structure and transfer the key side-chains of the peptide pharmacophore onto an oligomeric bis-peptide scaffold to create molecules with moderate or good affinity for the target protein...
  11. Novel Methylenecyclopropane Analogues as Anti-Human Herpesvirus 6 and 8 Agents
    Terry L Bowlin; Fiscal Year: 2010
    ..A second generation of MP analogues, the 2,2-bis-hydroxymethyl series, exhibited very good activity against HCMV...
  12. Transition states in G-protein coupled receptor signaling
    T M Iverson; Fiscal Year: 2010
    ..We have already shown that a cross-link can be formed using bis(sulfosuccinimidyl) suberate (BS3) or its cleavable analog 3,3'- dithiobis-succinimidylpropionate (DTSSP)...
  13. INTRA-TUMORAL METABOLIC HETEROGENEITY OF CERVICAL CANCER
    PERRY WAYNE GRIGSBY; Fiscal Year: 2013
    ..3'-Deoxy-3'-18F-fluorothymidine (FLT) (marker of cellular proliferation) and PET with copper(II)-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) (marker of assessment of hypoxia) to identify areas of metabolic concordance (..
  14. John M Sullivan; Fiscal Year: 2016
    ..LF has a brilliant autofluorescence under blue light excitation due to the dominant presence of toxic bis-retinoid pyridinium salts (A2E) and retinaldehyde dimers (RetDi)...
  15. Prostate cancer prevention by selenium supplementation
    Rayudu Gopalakrishna; Fiscal Year: 2012
    ..by extending this model to nude mice fed a diet supplemented with Se-methylselenocysteine or 1,4- phenylene-bis(methylene)selenocyanate...
  16. CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENTAL TOXICOLOGY PROGRAM
    CLARK ALGAIER; Fiscal Year: 2009
    ..It has been shown that the compound like bisphenol A (BPA) and bis-GMA were present in saliva after placement of a specific dental sealant that are shown to posses estrogenic ..
  17. IVAN B YANACHKOV; Fiscal Year: 2015
    ..In the previous phases of this project we developed a series of new bis-adenosine tetraphosphate (Ap4A) analogs, which inhibit platelet aggregation by a unique new mechanism, targeting ..
  18. Patrick M Woster; Fiscal Year: 2014
    ..We recently reported a series of (bis)guanidines and (bis)biguanides that are potent inhibitors of recombinant human LSD1...
  19. BDADs for Male Contraception
    John K Amory; Fiscal Year: 2013
    Almost fifty years ago, oral administration of Bis-dichloroacetyl-diamines (BDADs) such as WIN 18,446 was shown to safely, completely and reversibly inhibit spermatogenesis in men...
  20. Lois S Weisman; Fiscal Year: 2016
    PROJECT SUMMARY/ABSTRACT The low abundance signaling lipid, phosphatidylinositol (3,5)-bis phosphate (PI3,5P2) is present in all eukaryotes, and is postulated to be involved in multiple trafficking pathways from late endosomes...
  21. Christopher D Kontos; Fiscal Year: 2014
    ..Furthermore, these studies may lead to effective therapies for the treatment of PAD. ..
  22. Combinational Approaches to the Chemoprevention of Esophageal Cancer
    Tong Chen; Fiscal Year: 2012
    ..COX-2) inhibitor, celecoxib, inducible nitric oxide synthase (iNOS) inhibitor, S,S'-1,4- phenylene-bis(1,2-ethanediyl)bis-isothiourea (PBIT), and freeze-dried black raspberries (BRB) will increase efficacy against ..
  23. Ah Ng Tony Kong; Fiscal Year: 2016
    ..L.), usually contain three major components, curcumin (CUR;~77%), demethoxycurcumin (~17%) and bis-demethoxycurcumin (~3%), they are commonly used as botanical dietary supplements...
  24. Development of a Novel Lead Series Against Category A &B Bacterial Pathogens
    Terry L Bowlin; Fiscal Year: 2013
    ..overall objective of this project is to develop a novel chemical class of broad-spectrum therapeutic agents, the bis-indole lead series, for use against Gram-negative category A and B bacterial biodefense threats, and file an IND by ..
  25. Identification of Novel Small Molecules as Tau Protein Aggregation Inhibitors for
    ALAN D SNOW; Fiscal Year: 2011
    ..us to design and synthesize a class of [new chemical entities consisting of small molecules (200-400 MW) containing bis-catechols,] some of them found to be potent inhibitors of protein/peptide aggregates that are of central importance ..
  26. Regulation of motility and organelle assembly at the Pseudomonas aeruginosa pole
    Barbara I Kazmierczak; Fiscal Year: 2012
    ..FimX is a phosphodiesterase for bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP), a second messenger implicated in the post-..
  27. Christina Porucznik; Fiscal Year: 2015
    ..SPECIFIC AIMS 1. Conduct prospective, peri-ovulational biomonitoring for disinfection by-products (DBP) and bis-phenol-A (BPA) in a human preconception cohort using a novel strategy of self-collection of environmental and ..
  28. Targeting bone homing of the MSCs to augment bone formation
    Wei Yao; Fiscal Year: 2010
    ..We then chemically linked a bisphosphonate (a bone targeting agent) to LLP2A. This new hybrid drug, Bis-LLP2A, was found to concentrate in the bone surface...
  29. BAG3 mediates interplay of HIV-1 and JCV in brain
    Kamel Khalili; Fiscal Year: 2013
    ..abstract_text> ..
  30. Enhancing In Vitro Antimicrobial Activity of Common Antibiotics with Cyclopeptide
    Maria Ngu-Schwemlein; Fiscal Year: 2012
    ..towards these project objectives, we will synthesize a series of amphipathic cationic cyclopeptides and their bis-analogs by microwave-assisted solid-phase-peptide synthesis and evaluate their in vitro intrinsic antimicrobial ..
  31. A POLYMERIC DRUG DELIVERY SYSTEM FOR CANCER THERAPY
    JINDRICH H KOPECEK; Fiscal Year: 2010
    ..4-hydroxyphenyl retinamide and all- trans-retinoic acid, and conjugates with anticancer drugs, geldanamycin, 2,5-bis(6-hydroxymethyl-2- thienyl)furan, and mesochlorin e6 will be designed and synthesized...
  32. GLYCOSPHINGOLIPIDS IN MURINE NEURODEGENERATIVE DISEASES
    Thomas N Seyfried; Fiscal Year: 2012
    ..Our preliminary studies show for the first time elevated levels of the unusual phospholipid, bis(monoacylglycerol)phosphate in the brains of human SD and in the [unreadable]-gal -/-, and Hex[unreadable] -/- mice...
  33. A Novel Growth Regulatory Factor in Breast Cells
    MONICA MONTANO; Fiscal Year: 2012
    ..We reported that estrogens downregulate the expression of the transcription factor Hexamethylene-bis-acetamide-inducible protein 1 (HEXIM1), and HEXIM1, in turn, inhibits Estrogen Receptor (ER?) transcriptional ..
  34. Role of co-chaperone, BAG3, in muscle degeneration under physiological stress
    Shinichi Takayama; Fiscal Year: 2010
    ..in muscle cell survival under physiological stress, and may provide us clues for understanding molecular mechanisms of myofibrillar degeneration and for investigating the new target for therapy of muscular degenerative human diseases ..
  35. Using Technology To Deliver Brief Interventions in DUI Programs
    Katherine E Watkins; Fiscal Year: 2010
    ..We know that BIs are effective at reducing risky alcohol use and alcohol-related consequences with at-risk drinkers in diverse ..
  36. Ruthenium-based antimalarial agents
    ROBERTO A SANCHEZ-DELGADO; Fiscal Year: 2013
    ..2. To synthesize and evaluate Ru-trioxane and Ru-(bis) trioxane complexes as potential non-toxic antimalarial agents acting by radical alkylation mechanisms. 3...
  37. John W Chen; Fiscal Year: 2014
    ..We have recently shown that the MR imaging agent, bis-5HT-DTPA-Gd (MPO-Gd) is highly specific and sensitive to MPO activity in in vitro and in vivo experiments...
  38. Core-Shell Fiber Mesh for the Treatment of UI and PFD in Elderly Women
    MICHAEL P H LAU; Fiscal Year: 2011
    ..The fiber core and shell are composed of poly(glycerol sebacate) (PGS) and poly(1,3-Bis- (carboxyphenoxy)propane) (PCPP), respectively selected to tunably surface erode over several weeks...
  39. Curcumin to Augment Neonatal Lung Injury/Repair
    Reiko Sakurai; Fiscal Year: 2012
    ..Curcumin [1,7-bis (4'-hydroxy-3'-methoxyphenyl)-1,6-heptadiene-3,5-dione], a naturally occurring pigment derived from the ..
  40. Tobacco Cessation Training for accupuncture, massage, and chiropractic practition
    Myra L Muramoto; Fiscal Year: 2013
    ..Tobacco cessation brief interventions (BIs) are low-cost and effective for increasing quit attempts and quit rates...
  41. NICOLAS P SLUIS-CREMER; Fiscal Year: 2016
    ..a total of 7,265 compounds screened, we identified 3,39-[(3-carboxy-4-oxo-2,5-cyclohexadien-1- ylidene)methylene]bis[6-hydroxy-benzoic acid] (APEX-57219) as a promising "lead" compound...
  42. Alanna Schepartz; Fiscal Year: 2016
    ..bipartite tetracysteine display as well as a newly discovered orthogonal labeling strategy based on pro-fluorescent bis-boronic acids. We seek to achieve three major goals...
  43. Nonalcoholic steatohepatitis and Cytochrome P450 Enzymes
    Naga P Chalasani; Fiscal Year: 2010
    ..CYP2E1 activity and lipid peroxidation before and administering a selective mechanism-based CYP2E1 inhibitor, bis (diethylthiocarbamoyl) disulfide, (4) Studies have suggested that microsomal enzymes may play a role in the ..
  44. Drug Development of Ribonucleotide Reductase Inhibitor
    Yun Yen; Fiscal Year: 2012
    ..The bis- catechol pharmacophore is also novel and represents a new possible quenching mechanism underlying free radical ..
  45. John W Chen; Fiscal Year: 2014
    ..We have shown that the MR imaging agent, bis-5HT- DTPA-Gd (MPO-Gd) is highly sensitive and specific for detecting MPO activity...
  46. Shannon Gwin Mitchell; Fiscal Year: 2015
    ..In the Specialist Strategy, BIs are delivered by behavioral health counselors...
  47. Fatih M Uckun; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): We recently discovered the pentapeptide mimic 1,4-Bis (9-0 dihydroquinidinyl) phthalazine / hydroquinidine 1,4-phathalazinediyl diether (C-61) as a tyrosine kinase inhibitor targeting the substrate-..
  48. Daniel Romo; Fiscal Year: 2016
    ..axinellamine, and styloguanidine from a common cyclopentane intermediate bearing either cyclic urea-hydantoin or bis-cyclic guanidine heterocycles...
  49. Implementing and Evaluating INTERACT in VA CLCs
    Vincent Mor; Fiscal Year: 2013
    ..calls, will be gathered for use in both the implementation analyses as well as the Budget Impact Analyses (BIS)...
  50. CHEMISTRY AND BIOLOGY OF CARCINOGEN-DNA ADDUCTS
    Michael P Stone; Fiscal Year: 2010
    ..This Program Project seeks to understand mechanisms by which exposures to environmentally- and endogenously-produced bis-electrophiles, such as vinyl chloride, acrolein, crotonaldehyde, and 4- hydroxynonenal (4-HNE), induce genotoxic ..
  51. MARC ROBILLARD; Fiscal Year: 2015
    ..A bis(pyridinyl)tetrazine (tetrazine) conjugated metal will be radiolabeled with the ?-emitter 212Bi or its parent 212Pb ..
  52. H Ralph Rawls; Fiscal Year: 2016
    ..of Restorative Resins Abstract: In order to develop a novel restorative system with at least twice the lifetime of Bis-GMA/TEGDMA- based composites, their incomplete cure and susceptibility to hydrolysis and esterase degradation must ..
  53. iNOS/Akt Inhibotor for Colon Cancer Chemoprevention
    DHIMANT HARKISAN DESAI; Fiscal Year: 2010
    ..Several iNOS inhibitors have been reported for prevention of cancers. One such agents, S,S'-1,4-phenylene-bis(1,2- ethanediyl)bis-isothiourea (PBIT) was effective inhibitor in vivo for colonic Aberrant crypt foci (ACF) and ..
  54. Gary A Molander; Fiscal Year: 2015
    ..and its commercial synthetic precursor, (Me2N)2B-B(NMe2)2, will reduce dependency on the wholly inefficient bis(pinacoloato)diboron (B2pin2)...
  55. New Triterpenoids for Chemoprevention and Therapy of Cancer
    Michael B Sporn; Fiscal Year: 2013
    ..Our Specific Aims are as follows: (1) To continue to synthesize new triterpenoids and tricyclic bis-enones (TBEs) for chemoprevention of cancer...
  56. fMRI STUDIES OF EMOTIONAL CIRCUITRY IN DEPRESSION
    CHARLES RICHARD CONWAY; Fiscal Year: 2012
    ..We will correlate individual scores on key baseline variables (including HAMD scores, MASQ scores and BIS/BAS scores) with amygdala activity...
  57. Frederic C Blow; Fiscal Year: 2016
    ..The aims of the study are to develop, refine and test tailored motivational BIs with varied continuing booster reinforcements (Web vs...
  58. Peripheral endothelial and muscle cell pathology in cardiovascular disease
    JOSEPH MATTHEW MCCLUNG; Fiscal Year: 2011
    ....
  59. Novel Antibacterials Targeting Gram-negative Nonfermenters
    Michelle M Butler; Fiscal Year: 2010
    ..overall objective of this project is to develop a novel chemical class of broad-spectrum therapeutic agents, the bis-(indole) lead series, for use against Gram-negative nonfermenters...
  60. Anika A H Alvanzo; Fiscal Year: 2016
    ..However, to date there have been no studies testing trauma-informed BIs for high-risk drinkers;the activities of this proposal will lay the foundation for the eventual development of a ..
  61. b-Lactones: Bioactive Target and Vehicles for Synthesis
    Daniel Romo; Fiscal Year: 2010
    ..salinosporamides, we propose a synthesis of the oxazolomycin and neooxazolomcyin - lactam core involving modified bis-cyclizations...
  62. Repair of Interstrand Cross-linked Synthetic DNA
    Paul Miller; Fiscal Year: 2009
    ..1,8-Bis(nitrosoureido)-3,6- dioxaoctane, 1,8-bis(methylsulfonyl)-3,6-dioxaoctane and 1,8-bis(sulfamyl)-3,6-dioxaoctane ..
  63. NOVEL BENZAMIDE RIBOSIDE ANALOGUES AS ANTICANCER AGENTS
    Krzysztof Pankiewicz; Fiscal Year: 2001
    ..1 cells. Our recent studies found that stable bis(phosphonate) analogues of TAD and BAD showed even better therapeutic potential than active metabolites TAD and BAD ..
  64. Development of Anticancer 1,2-Bis(sulfonyl)hydrazines
    Alan Sartorelli; Fiscal Year: 2009
    ..Our laboratory has designed and synthesized a new class of tumor inhibitory prodrugs, the 1,2-bis(sulfonyl) hydrazines, which generate through activation reactive electrophilic structures that cross-link DNA...
  65. Engineered Spores as Fluorogenic Biological Indicators for Sterility Testing
    Boris Rotman; Fiscal Year: 2009
    ..the unique features of the F- spores in context with existing needs for rapid and reliable biological indicators (BIs) for sterility testing, BCR proposes a Phase II validation study of a rapid biological indicator (rBI) for steam ..
  66. Synthesis of Potentially Bioactive Peroxides by Electrophilic Activation
    SHELLI WAETZIG; Fiscal Year: 2009
    ..Develop electrophilic cyclizations of bis(hydroperoxy)acetals onto activated alkenes to prepare endoperoxides...
  67. Synthesis and Biology of Bengazole Analogs
    Peter Wipf; Fiscal Year: 2003
    ..Our specific aims in this collaborative project are: - Synthesis of bis-oxazoles, bis-oxazolines, bis-thiazoles and bis-thiazolines analogs of the anthelminthic marine natural product ..
  68. METVAN: A Novel Anticancer Agent
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Among the 25 bis(cyclopentadienyl)vanadium(IV) and 15 oxovanadium(IV) compounds synthesized and evaluated for anticancer activity, ..
  69. Hybridization of Oligonucleotide Probes with Duplex DNA
    Maxim Frank Kamenetskii; Fiscal Year: 2005
    ..A primary tool is a special class of pyrimidine peptide nucleic acid (PNA; a DNA synthetic mimic) - cationic bis-PNAs or PNA 'openers', known to effectively invade short purine tracts of dsDNA...
  70. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2003
    ..spermicides, we have rationally designed and synthesized several disubstituted metallocene derivatives, where bis(cyclopentadienyl) moieties are positioned in a tetrahedral symmetry and in a bent conformation with respect to the ..