B2M

Summary

Gene Symbol: B2M
Description: beta-2-microglobulin
Alias: IMD43, beta-2-microglobulin, beta chain of MHC class I molecules, beta-2-microglobin
Species: human

Top Publications

  1. pmc Tissue-specific and cell surface expression of human major histocompatibility complex class I heavy (HLA-B7) and light (beta 2-microglobulin) chain genes in transgenic mice
    J W Chamberlain
    Department of Human Genetics, Yale University School of Medicine, New Haven, CT 06510
    Proc Natl Acad Sci U S A 85:7690-4. 1988
  2. doi Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation
    Stefano Ricagno
    Department of Biomolecular Sciences and Biotechnology, CNR INFM and CIMAINA, University of Milano, Via Celoria 26, 20133 Milano, Italy
    Biochem Biophys Res Commun 380:543-7. 2009
  3. pmc Internalization of coxsackievirus A9 is mediated by {beta}2-microglobulin, dynamin, and Arf6 but not by caveolin-1 or clathrin
    Outi Heikkilä
    Division of Genetics and Physiology, Department of Biology, University of Turku, Vesilinnantie 5, 20014 Turun Yliopisto, Finland
    J Virol 84:3666-81. 2010
  4. pmc Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART
    Barbara Ensoli
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 5:e13540. 2010
  5. pmc HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes
    J D Weissman
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:11601-6. 1998
  6. pmc HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail
    Jeremiah F Roeth
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 167:903-13. 2004
  7. doi Urinary epidermal growth factor, monocyte chemotactic protein-1, and β2-microglobulin in children with ureteropelvic junction obstruction
    Fabio Bartoli
    Division of Pediatric Surgery, University of Foggia, Foggia, Italy
    J Pediatr Surg 46:530-6. 2011
  8. ncbi Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor
    Benjamin E Willcox
    Division of Biology 114 96, California Institute of Technology, Pasadena, California 91125, USA
    Nat Immunol 4:913-9. 2003
  9. doi Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease
    Ikuko Mizuta
    Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine, 2 2 B9 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Hum Genet 124:89-94. 2008
  10. ncbi Beta(2)-microglobulin and its deamidated variant, N17D form amyloid fibrils with a range of morphologies in vitro
    N M Kad
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK
    J Mol Biol 313:559-71. 2001

Research Grants

  1. RNA from Brush Cytology to Identify Aggressive Squamous Cell Carcinoma
    Joel L Schwartz; Fiscal Year: 2013
  2. DANIEL WILLIAM CRAMER; Fiscal Year: 2015
  3. IMMUNOCHEMICAL GENETICS OF MURINE ALLOANTIGENS
    James Michaelson; Fiscal Year: 1991
  4. Targeting surface b2M for myeloma and bone therapy
    Qing Yi; Fiscal Year: 2013
  5. Andrew S Levey; Fiscal Year: 2014
  6. FAS REGULATES T CELL DEVELOPMENT/FUNCTION IN LPR MICE
    Ralph C Budd; Fiscal Year: 2010
  7. Anti-beta2 microglobulin mAbs as a novel therapeutic agent in multiple myeloma
    Jing Yang; Fiscal Year: 2010
  8. Saul A Villeda; Fiscal Year: 2016
  9. Role of MHC molecules in NK recognition
    David H Raulet; Fiscal Year: 2010
  10. DEVELOPMENT OF NEW SCID MOUSE MODELS FOR AIDS RESEARCH
    Leonard Shultz; Fiscal Year: 1999

Detail Information

Publications219 found, 100 shown here

  1. pmc Tissue-specific and cell surface expression of human major histocompatibility complex class I heavy (HLA-B7) and light (beta 2-microglobulin) chain genes in transgenic mice
    J W Chamberlain
    Department of Human Genetics, Yale University School of Medicine, New Haven, CT 06510
    Proc Natl Acad Sci U S A 85:7690-4. 1988
    We introduced the human genes HLA-B7 and B2M encoding the heavy (HLA-B7) and light [beta 2-microglobulin (beta 2m)] chains of a human major histocompatibility complex class I antigen into separate lines of transgenic mice...
  2. doi Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation
    Stefano Ricagno
    Department of Biomolecular Sciences and Biotechnology, CNR INFM and CIMAINA, University of Milano, Via Celoria 26, 20133 Milano, Italy
    Biochem Biophys Res Commun 380:543-7. 2009
    ..8A resolution. The W60V mutant structural features are discussed, focusing on the roles of the DE loop and of residue 60 in relation to ?2m structure and its amyloid aggregation trends...
  3. pmc Internalization of coxsackievirus A9 is mediated by {beta}2-microglobulin, dynamin, and Arf6 but not by caveolin-1 or clathrin
    Outi Heikkilä
    Division of Genetics and Physiology, Department of Biology, University of Turku, Vesilinnantie 5, 20014 Turun Yliopisto, Finland
    J Virol 84:3666-81. 2010
    ..In conclusion, the internalization of CAV9 to A549 cells follows an endocytic pathway that is dependent on integrin alphaVbeta6, beta2-microglobulin, dynamin, and Arf6 but independent of clathrin and caveolin-1...
  4. pmc Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART
    Barbara Ensoli
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 5:e13540. 2010
    ..In contrast, these changes were opposite, absent or partial in the OBS population. These findings support the use of Tat immunization to intensify HAART efficacy and to restore immune homeostasis...
  5. pmc HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes
    J D Weissman
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:11601-6. 1998
    ..Thus, Tat repression of MHC class I transcription would be one mechanism by which HIV avoids immune surveillance...
  6. pmc HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail
    Jeremiah F Roeth
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 167:903-13. 2004
    ..In sum, our evidence suggests that binding of AP-1 to the Nef-MHC-I complex is an important step required for inhibition of antigen presentation by HIV...
  7. doi Urinary epidermal growth factor, monocyte chemotactic protein-1, and β2-microglobulin in children with ureteropelvic junction obstruction
    Fabio Bartoli
    Division of Pediatric Surgery, University of Foggia, Foggia, Italy
    J Pediatr Surg 46:530-6. 2011
    ..The aim of this study is to evaluate the urinary excretion of these cytokines and β2-microglobulin (β2M) in children with urine flow impairment at the ureteropelvic junction or who underwent pyeloplasty...
  8. ncbi Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor
    Benjamin E Willcox
    Division of Biology 114 96, California Institute of Technology, Pasadena, California 91125, USA
    Nat Immunol 4:913-9. 2003
    ..The structure shows how LIR-1 recognizes UL18 and diverse MHC class I molecules, and indicates that a similar mode of MHC class I recognition is used by other LIR family members...
  9. doi Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease
    Ikuko Mizuta
    Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine, 2 2 B9 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Hum Genet 124:89-94. 2008
    ..Of 302 SNPs in a total 137 genes, but excluding SNCA, SNPs in NDUFV2, FGF2, CALB1 and B2M showed significant association (P < 0.01; 882 cases and 938 control subjects)...
  10. ncbi Beta(2)-microglobulin and its deamidated variant, N17D form amyloid fibrils with a range of morphologies in vitro
    N M Kad
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK
    J Mol Biol 313:559-71. 2001
    ..Using kinetic experiments we suggest that the immature fibrils observed previously do not represent intermediates in the assembly of fully mature amyloid, at least under the conditions studied here...
  11. pmc The role of disulfide bond in the amyloidogenic state of beta(2)-microglobulin studied by heteronuclear NMR
    Hidenori Katou
    Institute for Protein Research, Osaka University, Yamadaoka 3 2, Suita, Osaka 565 0871, Japan
    Protein Sci 11:2218-29. 2002
    ....
  12. ncbi Molecular dynamics simulations of the unfolding of beta(2)-microglobulin and its variants
    Buyong Ma
    Basic Research Program, SAIC Frederick, Inc, Laboratory of Experimental and Computational Biology, NCI FCRDC, Frederick, MD 21702, USA
    Protein Eng 16:561-75. 2003
    ..These conformational changes may relate to polymerization tendencies of these variants...
  13. ncbi Direct measurement of the thermodynamic parameters of amyloid formation by isothermal titration calorimetry
    József Kardos
    Institute for Protein Research, Osaka University and CREST, Japan Science and Technology Agency, Yamadaoka 3 2, Suita, Osaka 565 0871, Japan
    J Biol Chem 279:55308-14. 2004
    ....
  14. ncbi Ultrasonication-induced amyloid fibril formation of beta2-microglobulin
    Yumiko Ohhashi
    Institute for Protein Research, Osaka University, and CREST, Japan Science and Technology Agency, Yamadaoka 3 2, Suita, Osaka 565 0871, Japan
    J Biol Chem 280:32843-8. 2005
    ..5. These results indicate that ultrasonication is one form of agitation triggering the formation of amyloid fibrils of beta2-m, producing fibrils adapted to the respective pH...
  15. ncbi A systematic study of the effect of physiological factors on beta2-microglobulin amyloid formation at neutral pH
    Sarah L Myers
    Astbury Centre for Structural Molecular Biology, Garstang Building, University of Leeds, Leeds LS2 9JT, United Kingdom
    Biochemistry 45:2311-21. 2006
    ....
  16. ncbi Amyloid formation under physiological conditions proceeds via a native-like folding intermediate
    Thomas R Jahn
    Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    Nat Struct Mol Biol 13:195-201. 2006
    ..The results demonstrate that aggregation pathways can involve self-assembly of highly native-like folding intermediates, and have implications for the prevention of this, and other, amyloid disorders...
  17. pmc A common beta-sheet architecture underlies in vitro and in vivo beta2-microglobulin amyloid fibrils
    Thomas R Jahn
    Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 283:17279-86. 2008
    ..Our results endorse the relevance of biophysical studies for the investigation of the molecular mechanisms of beta(2)-microglobulin fibrillogenesis, knowledge about which may inform understanding of the pathobiology of this protein...
  18. pmc Competition between intramolecular and intermolecular interactions in an amyloid-forming protein
    Katy E Routledge
    Astbury Centre for Structural Molecular Biology, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
    J Mol Biol 389:776-86. 2009
    ....
  19. doi A recurrent D-strand association interface is observed in β-2 microglobulin oligomers
    Matteo Colombo
    Dipartimento di Scienze Biomolecolari e Biotecnologie and CIMAINA, Universita di Milano, Italy
    FEBS J 279:1131-43. 2012
    ..Implications for β2m oligomerization are discussed...
  20. pmc Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin: roles of shear flow, hydrophobic surfaces, and α-crystallin
    P Patrizia Mangione
    From the Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom
    J Biol Chem 288:30917-30. 2013
    ..Elucidation of this crucial causative event in clinical amyloidosis should also help to explain the hitherto mysterious timing and location of amyloid deposition. ..
  21. ncbi Assembly and maturation of HLA-A and HLA-B antigens in vivo
    M S Krangel
    Cell 18:979-91. 1979
    ..These observations are discussed in relation to in vivo and in vitro studies on the biosynthesis of a variety of secreted proteins and membrane proteins...
  22. ncbi Beta 2-microglobulin gene is mutated in a human colon cancer cell line (HCT) deficient in the expression of HLA class I antigens on the cell surface
    S Gattoni-Celli
    Massachusetts General Hospital Cancer Center, Boston
    Cancer Res 52:1201-4. 1992
    ..Therefore, it would appear that in HCT cells the beta 2m genes have undergone two different mutational changes. This is the first molecular demonstration of beta 2m mutations in a human epithelial cell line...
  23. ncbi Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution
    M A Saper
    Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138
    J Mol Biol 219:277-319. 1991
    ..A possible role for beta 2m in stabilizing permissible peptide complexes during folding and assembly is presented...
  24. ncbi Structure of the human class I histocompatibility antigen, HLA-A2
    P J Bjorkman
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
    Nature 329:506-12. 1987
    ..A large groove between the alpha-helices provides a binding site for processed foreign antigens. An unknown 'antigen' is found in this site in crystals of purified HLA-A2...
  25. ncbi The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit
    D Gussow
    Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Amsterdam
    J Immunol 139:3132-8. 1987
    The human genomic clone pb2m13 contains a functional beta 2-microglobulin (B2m) gene, which upon transfection is readily expressed in murine fibroblasts...
  26. pmc The solution structure of human beta2-microglobulin reveals the prodromes of its amyloid transition
    Giuliana Verdone
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, P le Kolbe 4, 33100 Udine, Italy
    Protein Sci 11:487-99. 2002
    ....
  27. ncbi Conformation of beta 2-microglobulin amyloid fibrils analyzed by reduction of the disulfide bond
    Dong Pyo Hong
    Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 277:21554-60. 2002
    ..Taken together, the disulfide bond once exposed to the solvent upon acid denaturation may be progressively buried in the interior of the amyloid fibrils during its formation...
  28. ncbi Structural properties of an amyloid precursor of beta(2)-microglobulin
    Victoria J McParland
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds, LS2 9JT UK
    Nat Struct Biol 9:326-31. 2002
    ..The data offer a rationale as to why these proteins are both amyloidogenic at low pH and suggest that amyloidosis of these and other proteins may involve ordered assembly from a precursor with similar conformational features...
  29. ncbi Mapping the core of the beta(2)-microglobulin amyloid fibril by H/D exchange
    Masaru Hoshino
    Institute for Protein Research, Osaka University, Yamadaoka 3 2, Suita, Osaka 565 0871, Japan
    Nat Struct Biol 9:332-6. 2002
    ..The present method could be used to obtain residue-specific conformational information of various amyloid fibrils, even though it does not provide a high resolution three-dimensional structure...
  30. pmc Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties
    Chi H Trinh
    Astbury Centre for Structural Molecular Biology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    Proc Natl Acad Sci U S A 99:9771-6. 2002
    ....
  31. ncbi Amyloid-forming peptides from beta2-microglobulin-Insights into the mechanism of fibril formation in vitro
    Susan Jones
    School of Biochemistry and Molecular Biology, University of Leeds, UK
    J Mol Biol 325:249-57. 2003
    ....
  32. ncbi Complete loss of HLA class I antigen expression on melanoma cells: a result of successive mutational events
    Annette Paschen
    Skin Cancer Unit, German Cancer Research Center, University Hospital Mannheim, Mannheim, Germany
    Int J Cancer 103:759-67. 2003
    ..Antigen presentation was not inducible with IFN-gamma but could be restored after transfection of tumor cells with b2m cDNA, indicating a defect in b2m expression...
  33. ncbi Hierarchical assembly of beta2-microglobulin amyloid in vitro revealed by atomic force microscopy
    Neil M Kad
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    J Mol Biol 330:785-97. 2003
    ..Comparative height analysis from the TM-AFM data allows each of the mature fibril types and single protofilaments to be identified unambiguously, and reveals that the assembly occurs via a hierarchy of morphological states...
  34. ncbi Role of the N and C-terminal strands of beta 2-microglobulin in amyloid formation at neutral pH
    Susan Jones
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    J Mol Biol 330:935-41. 2003
    ..The data are consistent with the view that perturbation of the N and C-terminal edge strands is an important feature in the generation of assembly-competent states of beta(2)m...
  35. ncbi A systematic investigation into the effect of protein destabilisation on beta 2-microglobulin amyloid formation
    David P Smith
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    J Mol Biol 330:943-54. 2003
    ..Moreover, we demonstrate that the formation of fibrils with different morphologies in vitro correlates with the relative population of different precursor states...
  36. ncbi Amyloid fibril formation in the context of full-length protein: effects of proline mutations on the amyloid fibril formation of beta2-microglobulin
    Takeshi Chiba
    Institute for Protein Research, Osaka University, and CREST, Japan Science and Technology Corp, Yamadaoka 3 2, Suita, Osaka 565 0871, Japan
    J Biol Chem 278:47016-24. 2003
    ..The present results reveal that, in addition, stability of the amyloid fibrils is a key factor determining the amyloidogenic potential of the proteins...
  37. ncbi Beta-2 microglobulin in ESRD: an in-depth review
    James F Winchester
    RenalTech International, LLC, New York, NY 10021, USA
    Adv Ren Replace Ther 10:279-309. 2003
    ..There seems to be a relative risk reduction in mortality when patients are treated with dialysis membranes that have a higher clearance of beta-2 microglobulin...
  38. pmc An amyloid-forming segment of beta2-microglobulin suggests a molecular model for the fibril
    Magdalena I Ivanova
    Howard Hughes Medical Institute and University of California Department of Energy Institute of Genomics and Proteomics, Box 951570, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:10584-9. 2004
    ..These observations are consistent with a proposed Zipper-spine model for beta2M amyloid, in which the spine of the fibril consists of an anhydrous beta-sheet...
  39. ncbi Conformation of amyloid fibrils of beta2-microglobulin probed by tryptophan mutagenesis
    Miho Kihara
    Institute for Protein Research, Osaka University, and CREST, Japan Science and Technology Agency, Yamadaoka 3 2, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:31061-9. 2006
    ..In addition, the fluorescence spectra of fibrils prepared at pH 2.5 and 7.0 revealed a large difference in the fluorescence intensity for W60-beta2-m, implying a major structural difference between them...
  40. pmc 3D structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR
    Kentaro Iwata
    Institute for Protein Research, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 103:18119-24. 2006
    ..By revealing the structure of beta(2)-microglobulin protofilament-like fibrils, this work represents technical progress in analyzing amyloid fibrils in general through solid-state NMR...
  41. ncbi Targeting beta2-microglobulin mediated signaling as a novel therapeutic approach for human renal cell carcinoma
    Takeo Nomura
    Molecular Urology and Therapeutics Program, Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Urol 178:292-300. 2007
    ....
  42. ncbi High-resolution crystal structure of beta2-microglobulin formed at pH 7.0
    Kentaro Iwata
    Institute for Protein Research, Osaka University, and CREST, Japan Science and Technology Agency, Yamadaoka 3 2, Suita, Osaka, Japan
    J Biochem 142:413-9. 2007
    ..We consider that the enhanced fibrillation is more directly coupled with the decreased stability leading to the increased propensity of exposing amyloidogenic regions...
  43. pmc Fibril growth kinetics reveal a region of beta2-microglobulin important for nucleation and elongation of aggregation
    Geoffrey W Platt
    Astbury Centre for Structural Molecular Biology and Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
    J Mol Biol 378:251-63. 2008
    ....
  44. doi Kinetic coupling of folding and prolyl isomerization of beta2-microglobulin studied by mutational analysis
    Michiko Sakata
    Institute for Protein Research, Osaka University and CREST, Japan Science and Technology Agency, Yamadaoka 3 2, Suita, Osaka 565 0871, Japan
    J Mol Biol 382:1242-55. 2008
    ....
  45. pmc Beta2-microglobulin signaling blockade inhibited androgen receptor axis and caused apoptosis in human prostate cancer cells
    Wen Chin Huang
    Molecular Urology and Therapeutics Program, Department of Urology and Winship Cancer Institute, Emory University School of Medicine, GA 30322, USA
    Clin Cancer Res 14:5341-7. 2008
    ..The objective of this study is to determine the mechanism by which targeting beta2M using anti-beta2M antibody inhibited growth and induced apoptosis in prostate cancer cells...
  46. doi DE loop mutations affect beta2-microglobulin stability and amyloid aggregation
    Stefano Ricagno
    Department of Biomolecular Sciences and Biotechnology, CNR INFM and CIMAINA, University of Milano, Milano, Italy
    Biochem Biophys Res Commun 377:146-50. 2008
    ..The experimental evidences gathered on the two mutants reinforce the hypothesis that conformational strain in the DE loop can affect beta2m stability and amyloid aggregation properties...
  47. pmc Overexpression of beta2-microglobulin is associated with poor survival in patients with oral cavity squamous cell carcinoma and contributes to oral cancer cell migration and invasion
    C H Chen
    Department of Otolaryngology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Br J Cancer 99:1453-61. 2008
    ..Taken together, our results suggest that beta2M expression in the tissues is associated with survival and may be involved in tumour progression and metastasis in OCSCC...
  48. doi A comprehensive model for packing and hydration for amyloid fibrils of beta2-microglobulin
    Young Ho Lee
    Institute for Protein Research, Osaka University and CREST, Japan Science and Technology Agency, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 284:2169-75. 2009
    ..These volumetric differences would result from the nature of main-chain-dominated fibrillogenesis. We suggest comprehensive models for these three types of fibrils illustrating packing and hydrational states...
  49. doi Knockdown of beta2-microglobulin perturbs the subcellular distribution of HFE and hepcidin
    Lavinia Bhatt
    Department of Biochemistry, Molecular Cell Biology Laboratory, Biosciences Institute, University College Cork, Cork, Ireland
    Biochem Biophys Res Commun 378:727-31. 2009
    ..In summary, our data suggest that beta2M is essential for the correct subcellular distribution of both HFE and hepcidin, two proteins, which are critical for iron homeostasis...
  50. pmc Delineating the conformational elements responsible for Cu(2+)-induced oligomerization of beta-2 microglobulin
    Dorottya V Blaho
    Department of Molecular Biophysics and Biochemistry Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520 8114, USA
    Biochemistry 48:6610-7. 2009
    ..Here, we show that this strong binding affinity need not be directly coupled to oligomerization. We interpret our results in terms of the known structures of beta2m(apo) and a reversible hexameric state of beta2m(holo)...
  51. pmc Androgen receptor survival signaling is blocked by anti-beta2-microglobulin monoclonal antibody via a MAPK/lipogenic pathway in human prostate cancer cells
    Wen Chin Huang
    Uro Oncology Research Program, Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Biol Chem 285:7947-56. 2010
    ....
  52. pmc Structure of the preamyloid dimer of beta-2-microglobulin from covalent labeling and mass spectrometry
    Vanessa Leah Mendoza
    Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Biochemistry 49:1522-32. 2010
    ..In addition, our data clearly indicate that a dimer interface involving the interactions of D-D strands from separate protein units as seen in the recent crystal structures of two mutant beta2m oligomers is unlikely...
  53. pmc Stacked sets of parallel, in-register beta-strands of beta2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labeling
    Carol L Ladner
    Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 285:17137-47. 2010
    ..The results suggest an organization more complex than the accordion-like beta-sandwich structure commonly proposed for amyloid fibrils...
  54. pmc Elongated oligomers in beta2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry
    David P Smith
    Astbury Centre for Structural Molecular Biology, Institute of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, United Kingdom
    Proc Natl Acad Sci U S A 107:6794-8. 2010
    ....
  55. pmc Magic angle spinning NMR analysis of beta2-microglobulin amyloid fibrils in two distinct morphologies
    Galia T Debelouchina
    Department of Chemistry and Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 132:10414-23. 2010
    ..Our results suggest that the distinct macroscopic morphological features observed for the two types of fibrils result from variations in structure and dynamics at the molecular level...
  56. pmc Effect of tetracyclines on the dynamics of formation and destructuration of beta2-microglobulin amyloid fibrils
    Sofia Giorgetti
    Department of Biochemistry, University of Pavia, via Taramelli 3b, 27100 Pavia, Italy
    J Biol Chem 286:2121-31. 2011
    ..In these tissues, the doxycycline concentration reaches values several folds higher than those resulting in inhibition of amyloidogenesis and amyloid destructuration in vitro...
  57. pmc β₂-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages
    Cong Liu
    University of California Los Angeles United States Department of Energy Institute for Genomics and Proteomics, University of California, Los Angeles, Los Angeles, California, USA
    Nat Struct Mol Biol 18:49-55. 2011
    ..The structures of the dimer and the zipper spine fit well into an atomic model for this fibrillar form of β₂m, which assembles slowly under physiological conditions...
  58. pmc Inhibition of beta2-microglobulin amyloid fibril formation by alpha2-macroglobulin
    Daisaku Ozawa
    Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    J Biol Chem 286:9668-76. 2011
    ....
  59. pmc Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant
    Katarzyna Domanska
    Department of Molecular and Cellular Interactions, Vlaams Instituut voor Biotechnologie, Pleinlaan 2, B 1050 Brussels, Belgium
    Proc Natl Acad Sci U S A 108:1314-9. 2011
    ....
  60. doi The monomer-seed interaction mechanism in the formation of the β2-microglobulin amyloid fibril clarified by solution NMR techniques
    Kotaro Yanagi
    Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Mol Biol 422:390-402. 2012
    ..Our results provide general information about the extension of amyloid fibrils...
  61. doi Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin
    Sophie Valleix
    Laboratoire de Biochimie et de Génétique Moléculaire, Universite Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine Paris, Assistance Public Hôpitaux de Paris AP HP, Paris, France
    N Engl J Med 366:2276-83. 2012
    ..Comprehensive biophysical characterization of the β(2)-microglobulin variant, including its 1.40-Å, three-dimensional structure, should allow further elucidation of fibrillogenesis and protein misfolding...
  62. pmc Expanding the repertoire of amyloid polymorphs by co-polymerization of related protein precursors
    Claire J Sarell
    Astbury Centre for Structural Molecular Biology and School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 288:7327-37. 2013
    ....
  63. pmc Comparison of serum concentrations of β-trace protein, β2-microglobulin, cystatin C, and creatinine in the US population
    Stephen P Juraschek
    Departments of Epidemiology and Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Clin J Am Soc Nephrol 8:584-92. 2013
    ..This study compares the distribution of all four markers in the general population and their associations with possible determinants of GFR...
  64. pmc Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers
    Gennaro Esposito
    Dipartimento di Scienze Mediche e Biologiche, Universita di Udine, 33100 Udine, Italy
    J Biol Chem 288:17844-58. 2013
    ..Our findings are highly relevant to the emerging view that molecular chaperone action is intimately involved in the prevention of in vivo amyloid fibril formation...
  65. doi Oligomeric states along the folding pathways of β2-microglobulin: kinetics, thermodynamics, and structure
    E Rennella
    Institut de Biologie Structurale, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    J Mol Biol 425:2722-36. 2013
    ..This excited state becomes more populated in the transient I-state due to the destabilization of the native conformation by the trans-Pro32 configuration. ..
  66. pmc Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis
    Saskia Vanderhaegen
    Structural Biology Research Centre, VIB, Pleinlaan 2, 1050, Brussel, Belgium Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussel, Belgium
    Protein Sci 22:1349-57. 2013
    ....
  67. ncbi Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP
    J W Lewis
    Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, UK
    Curr Biol 6:873-83. 1996
    ....
  68. ncbi Competing pathways determine fibril morphology in the self-assembly of beta2-microglobulin into amyloid
    Walraj S Gosal
    School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, UK
    J Mol Biol 351:850-64. 2005
    ....
  69. ncbi Main-chain dominated amyloid structures demonstrated by the effect of high pressure
    Eri Chatani
    Institute for Protein Research, Osaka University and CREST, Japan Science and Technology Agency, Suita, Osaka 565 0871, Japan
    J Mol Biol 352:941-51. 2005
    ..Moreover, the amyloid structure without optimal packing will enable various isoforms to form, suggesting the structural basis of multiple forms of amyloid fibrils in contrast to the unique native-fold...
  70. ncbi Beta2-microglobulin mutations in microsatellite unstable colorectal tumors
    Matthias Kloor
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 121:454-8. 2007
    ..However, no beta2m mutations were observed in metastasized CRCs (UICC stage IV, p=0.04). These results suggest that functional beta2m may be necessary for distant metastasis formation in CRC patients...
  71. ncbi Prognostic relevance of serum beta2 microglobulin in patients with follicular lymphoma treated with anthracycline-containing regimens. A GISL study
    Massimo Federico
    Dipartimento di Oncologia ed Ematologia, Centro Oncologico Modenese, Universita di Modena e Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
    Haematologica 92:1482-8. 2007
    ..The present study examined the influence of beta2M levels on overall survival (OS) of patients with follicular lymphoma (FL)...
  72. doi The prognostic significance of serum beta2 microglobulin levels in acute myeloid leukemia and prognostic scores predicting survival: analysis of 1,180 patients
    Apostolia Maria Tsimberidou
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:721-30. 2008
    ..Serum beta(2) microglobulin (beta2M) is prognostic in other hematologic malignancies; therefore, we evaluated its prognostic significance in acute myeloid leukemia (AML)...
  73. ncbi Unfolding, aggregation, and seeded amyloid formation of lysine-58-cleaved beta 2-microglobulin
    Niels H H Heegaard
    Department of Autoimmunology, Statens Serum Institut, DK 2300 Copenhagen S, Denmark
    Biochemistry 44:4397-407. 2005
    ....
  74. ncbi [On-line sequential hemodiafiltration (HDF-OL-S): a new therapeutic option]
    J Kanter
    Servicio de Nefrologia, Unidad de Hemodiálisis, Hospital G U Gregorio Marañón, Madrid, Espana
    Nefrologia 28:433-8. 2008
    ..of achieving at least 20 litters ultrafiltration in postdilution mode and 70% reduction of beta-2-Microglobulin (B2M), however it requires a vascular access's high blood flow...
  75. ncbi Prognostic factors in follicular lymphoma: the importance of beta-2 microglobulin
    Araceli Cánovas
    Department of Internal Medicine, Hospital de Cruces, Faculty of Medicine UPV Baracaldo, Vizcaya, Spain
    Tumori 96:117-21. 2010
    ..Index (FLIPI) is a useful tool for the prognostic assessment of follicular lymphoma but beta-2 microglobulin (B2M) was not incorporated in this index...
  76. ncbi Cloning of the beta 2-microglobulin gene in the zebrafish
    H Ono
    Max Planck Institut fur Biologie, Abteilung Immungenetik, Tubingen, Germany
    Immunogenetics 38:1-10. 1993
    ..In mammals, the beta 2m-encoding gene (B2m) is found on a chromosome different from the Mhc proper...
  77. ncbi Serum beta 2-microglobulin in malignant lymphoproliferative disorders
    L Melillo
    Divisione di Ematologia, Ospedale Generale Regionale Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Foggia
    Tumori 74:129-35. 1988
    Beta 2-microglobulin (B2m) was measured on serum samples in 274 patients with acute and chronic lymphoproliferative disorders (85 non-Hodgkin lymphomas-NHL, 30 Hodgkin lymphomas-HL, 34 B-cell chronic lymphocytic leukemias-B-CLL, 8 ..
  78. ncbi An impaired breeding phenotype in mice with a genetic deletion of beta-2 microglobulin and diminished MHC class I expression: role in reproductive fitness
    Joanne C Cooper
    Department of Experimental Biology, Huntingdon Life Sciences Ltd, Alconbury, Huntingdon, Cambridgeshire PE28 4HS, England
    Biol Reprod 77:274-9. 2007
    Beta-2 microglobulin (B2M) plays a pivotal role in the biology of mammals, including its association with major histocompatibility complex (MHC) Class I gene products...
  79. ncbi Decline in beta-2 microglobulin levels after antitubercular therapy in tubercular patients with HIV infection
    A Wanchu
    Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Chest Dis Allied Sci 43:211-5. 2001
    ..Beta-2 microglobulin (B2M) is a useful marker to study the state of immune activation among the HIV infected. Objective...
  80. doi Beta-2-microglobulin is an independent predictor of progression in asymptomatic multiple myeloma
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont and Maggiore della Carita Hospital, Novara, Italy
    Cancer 116:2188-200. 2010
    Although serum beta-2 microglobulin (B2M) represents a key variable for symptomatic multiple myeloma (MM) prognostication, its role in predicting the risk of progression of asymptomatic MM to symptomatic disease has not been explored.
  81. ncbi Effect of tibolone on cytochrome c oxidase I, beta-2-microglobulin and vascular endothelial growth factor gene expression in the lower urinary tract of castrated rats
    M G Hamerski
    Gynecology Department, Urogynecology and Reconstructive Pelvic Surgery Division, Federal University of Sao Paulo, Brazil
    Clin Exp Obstet Gynecol 33:233-7. 2006
    ..of this study was to evaluate the effect of tibolone on cytochrome oxidase I (COX I), beta-2-microglobulin (B2M) and vascular endothelial growth factor (VEGF) gene expression in the lower urinary tract of castrated rats...
  82. pmc Dynamic motions of 1,6-diphenyl-1,3,5-hexatriene in interdigitated C(18):C(10)phosphatidylcholine bilayers
    Y L Kao
    Department of Biochemistry, Meharry Medical College, Nashville, Tennessee 37208
    Biophys J 58:947-56. 1990
    ..During the phase transition of C(18):C(10)PC, DPH exhibits a thermal coefficient b2M = 0.41 - 0...
  83. pmc Characterization of housekeeping genes in zebrafish: male-female differences and effects of tissue type, developmental stage and chemical treatment
    Amy T McCurley
    Department of Biology, Boston University, Boston, MA 02215, USA
    BMC Mol Biol 9:102. 2008
    ....
  84. ncbi Pathogenesis of beta2-microglobulin amyloidosis
    K Ohashi
    Department of Pathology, Tokyo Metropolitan Komagome Hospital, 3 18 22, Honkomagome, Bunkyo ku, Tokyo 113 0021, Japan
    Pathol Int 51:1-10. 2001
    Hemodialysis-related amyloidosis is a relatively new form of systemic amyloidosis, with beta2-microglobulin (B2M) being identified as the major constituent protein...
  85. pmc Validation of putative reference genes for gene expression studies in human hepatocellular carcinoma using real-time quantitative RT-PCR
    Vito R Cicinnati
    Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    BMC Cancer 8:350. 2008
    ..Here, a systematic evaluation of six putative reference genes for gene expression studies in human hepatocellular carcinoma (HCC) is presented...
  86. ncbi Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice
    S Babu
    Department of Pathology, University of Connecticut Health Center, Farmington 06030, USA
    J Immunol 161:1428-32. 1998
    ..strains of mice with varying levels of NK cell activity reveal that NOD/LtSz-scid/scid and NOD/LtSz-scid/scid B2m(null) mice (with diminished to absent NK cell activity respectively), are nonpermissive to worm growth, while C...
  87. pmc Selection of reference genes for quantitative real-time PCR in a rat asphyxial cardiac arrest model
    Kristina Langnaese
    Institute of Medical Neurobiology, University of Magdeburg, Leipziger Str, 44, D 39120 Magdeburg, Germany
    BMC Mol Biol 9:53. 2008
    ..present study aimed to determine the expression stability of ten commonly used reference genes (Actb, actin, beta; B2m, beta-2 microglobulin;CypA, cyclophilin A; Gapdh, glyceraldehyde-3-phosphate dehydrogenase; Hprt, hypoxanthine ..
  88. doi Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes
    Ian A Johnston
    School of Biology, University of St Andrews, St Andrews, Fife KY16 8LB, UK
    J Exp Biol 212:1781-93. 2009
    ..were mostly involved in cell-cell interactions and cytokine pathways and included beta-2-microglobulin precursor (b2m), an orthologue of complement component 4, invariant chain-like protein 1 (iclp), CD9 antigen-like (cd9l), and ..
  89. doi [Feasibility between AN69 and hemodiafiltration online]
    Jacky Potier
    Service de néphrologie hémodialyse, Centre hospitalier public du Cotentin, BP208, Cherbourg cedex, France
    Nephrol Ther 6:21-7. 2010
    Removal of the middle molecules (MM) weight toxins, and particularly of beta-2-microglobuline (b2M) is made first by convection technique with membranes habitually used in hemodiafiltration online (HDFOL)...
  90. ncbi Beta-2 microglobulin amyloidosis presenting as bilateral ovarian masses: a case report and review of the literature
    Sharon L Mount
    Division of Anatomic Pathology, Department of Pathology, University of Vermont Fletcher Allen Health Care, Burlington, Vermont 05405, USA
    Am J Surg Pathol 26:130-3. 2002
    We report a case of systemic beta-2 microglobulin amyloidosis (B2M) in which the initial clinical presentation was that of bilateral ovarian masses...
  91. ncbi Serum beta2-microglobulin levels in hepatitis B e antigen-negative chronic hepatitis B patients under long term lamivudine monotherapy: relationship with virological breakthrough
    Ioannis S Elefsiniotis
    Department of Hepatogastroenterology, University of Athens, Helena Venizelou Hospital, Athens, Greece
    Can J Gastroenterol 18:307-13. 2004
    ..To evaluate the predictive value of serum beta2-microglobulin (beta2m) levels for virological breakthrough in hepatitis B e antigen-negative chronic hepatitis B patients under long term lamivudine monotherapy...
  92. pmc Presensitization by skin grafting from major histocompatibility complex class I or major histocompatibility complex class II deficient mice identifies class I antigens as inducers of allosensitization
    S Qian
    Pittsburgh Transplantation Institute, University of Pittsburgh, Pennsylvania, USA
    Immunology 85:82-7. 1995
    ..In contrast, presensitization with skin from b2m (beta 2-m mutant; class I deficient) mice did not significantly affect the survival of either organ graft...
  93. pmc Quantitative TaqMan real-time PCR assays for gene expression normalisation in feline tissues
    Yvonne Kessler
    University of Zurich, Switzerland
    BMC Mol Biol 10:106. 2009
    ....
  94. ncbi Characterization of an expressible nonclassical class I HLA gene
    M A Pook
    University Department of Medical Genetics, St Mary s Hospital, Manchester, United Kingdom
    Hum Immunol 32:102-9. 1991
    ..The resulting construct was transfected into the P815-B2M cell line, a derivative of the mouse mastocytoma P815 (HTR) line which expressed human beta2-microglobulin ..
  95. ncbi Responses against antigens encoded by the H-3 histocompatibility locus: antigens stimulating class I MHC- and class II MHC-restricted T cells are encoded by separate genes
    D C Roopenian
    Jackson Laboratory, Bar Harbor, ME 04609
    Immunogenetics 30:335-43. 1989
    ..Taken together, these data suggest that in addition to two genes (B2m and Cd-1) within the H-3 region whose products typically stimulate class I MHC-restricted CTL, there is at least ..
  96. ncbi Evaluation and validation of housekeeping genes in response to ionizing radiation and chemical exposure for normalizing RNA expression in real-time PCR
    Malathi Banda
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Mutat Res 649:126-34. 2008
    ..18S rRNA, acidic ribosomal protein, beta-actin, cyclophilin, GAPDH, phosphoglycerokinase, beta-2 microglobulin (B2M), beta-glucuronidase, hypoxanthine phosphoribosyltransferase and transferrin receptor showed no significant ..
  97. doi Determination of internal controls for quantitative real time RT-PCR analysis of the effect of Edwardsiella tarda infection on gene expression in turbot (Scophthalmus maximus)
    Wei Dang
    Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, PR China
    Fish Shellfish Immunol 30:720-8. 2011
    ..ACTB), ribosomal protein L17 (RPL17), α-tubulin (TUBA), elongation factor-1-α(EF1A), β-2-Microglobulin (B2M), RNA polymerase II subunit D (RPSD), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and 18S ribosomal RNA (18S ..
  98. ncbi Genomics of osteoarthritis
    Thomas Aigner
    Cartilage Research Group, Department of Pathology, University of Erlangen Nurnberg, Erlangen Germany
    Curr Opin Rheumatol 15:634-40. 2003
    ....
  99. ncbi The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor
    Ho Geun Yoon
    Department of Biochemistry and Molecular Biology, Center for Chronic Metabolic Disease Research, College of Medicine, Yonsei University, Seoul, South Korea
    Mol Endocrinol 20:1048-60. 2006
    ..prostate-specific antigen), TSC22 (TSC22 domain family member 1), NKX3-1 (NK3 transcription factor locus 1), and B2M(beta-2-microglobulin)...
  100. pmc Selection of reference genes for quantitative RT-PCR studies in striped dolphin (Stenella coeruleoalba) skin biopsies
    Giacomo Spinsanti
    Evolutionary Biology Department, University of Siena, Siena, Italy
    BMC Mol Biol 7:32. 2006
    ..A systematic evaluation of potential reference genes in cetacean skin biopsies is presented, in order to validate future qRT-PCR studies aiming at using the expression of selected genes as non-lethal biomarkers...
  101. ncbi Protective effect of Gui Qi mixture on the progression of diabetic nephropathy in rats
    Y W Zhang
    Department of Chinese with Western Medicine, Zhongnan Hospital, Wuhan University, Wuhan, China
    Exp Clin Endocrinol Diabetes 114:563-8. 2006
    ..Our results suggest that GQM alleviates the disorder in blood glucose and lipids, protects against the progression of renal nephropathy in diabetic rats, probably by inhibiting the expression of AngII and TGF-beta (1) mRNA...

Research Grants31

  1. RNA from Brush Cytology to Identify Aggressive Squamous Cell Carcinoma
    Joel L Schwartz; Fiscal Year: 2013
    ..previously published this method and have identified 2 specific markers for OSCC, in hamsters and humans, beta 2 microglobulin (B2M) and cytochrome p450 1B1 (CYP1B1)...
  2. DANIEL WILLIAM CRAMER; Fiscal Year: 2015
    ..However, adding HE4, CA72.4, and beta-2-microglobulin (B2M) plus epidemiologic variables like ovulatory cycles, endometriosis, body mass index, and family history of breast ..
  3. IMMUNOCHEMICAL GENETICS OF MURINE ALLOANTIGENS
    James Michaelson; Fiscal Year: 1991
    ..2) to carry out studies on the genetics of beta 2 microglobulin in man by utilizing a restriction- fragment polymorphism of the B2M gene 3) to produce additional Qa/TL ..
  4. Targeting surface b2M for myeloma and bone therapy
    Qing Yi; Fiscal Year: 2013
    ..abstract_text> ..
  5. Andrew S Levey; Fiscal Year: 2014
    ..markers [3 low molecular weight serum proteins: [unreadable]-trace protein (BTP), [unreadable]-2 microglobulin (B2M), and tumor associated trypsin inhibitor (TATI);and 1 metabolite: 2-([unreadable]-mannopyranosyl)-L-tryptophan (MPT,..
  6. FAS REGULATES T CELL DEVELOPMENT/FUNCTION IN LPR MICE
    Ralph C Budd; Fiscal Year: 2010
    ..TCR/MHC avidity will be decreased by transferring polyclonal CD8+ cells (wild-type, Ipr, or Bim-/-) into scid, b2m-/-scid, and TAP-/-scid mice...
  7. Anti-beta2 microglobulin mAbs as a novel therapeutic agent in multiple myeloma
    Jing Yang; Fiscal Year: 2010
    ..The candidate recently made a novel and exciting discovery that anti-beta2- microglobulin (b2M) monoclonal antibodies (mAbs) had strong apoptotic activity in myeloma cells...
  8. Saul A Villeda; Fiscal Year: 2016
    ..Furthermore, I identified a subset of systemic immune factors - [unreadable]2-Microglobulin (B2M), CCL11 and CCL2 -, as potential regulators of neurogenesis and cognitive function...
  9. Role of MHC molecules in NK recognition
    David H Raulet; Fiscal Year: 2010
    ..We showed earlier that NK cells in mice that lack MHC class I altogether (e.g. b2m-/- knockouts) are similarly hyporesponsive and are self-tolerant despite the absence of inhibition by MHC class I...
  10. DEVELOPMENT OF NEW SCID MOUSE MODELS FOR AIDS RESEARCH
    Leonard Shultz; Fiscal Year: 1999
    ..Genes to be crossed individually onto the NOD/LtSz-scid/scid background include: (a) the beta2 microglobulin (B2m) disrupted allele; (b) the MHC class II (I-A-beta) disrupted allele; (c) the invariant chain (Ii) disrupted allele; ..
  11. HGF Induces Robust Human Thymopoiesis in Mice
    Jan Nolta; Fiscal Year: 2004
    ..factor (HGF) with purified human stem cells causes massive human T lymphocyte development and expansion in NOD/SCID/B2M null mice...
  12. HEREDITARY HEMOCHROMATOSIS
    JAMES KUSHNER; Fiscal Year: 2001
    ..the b2 microglobulin gene has been knocked out, small intestinal and bone marrow transplantation studies between (b2m -/-) and wt C57BL/6 mice will be carried out to evaluate whether cellular iron egress is disregulated due to ..
  13. IMMUNOGENETIC STUDIES OF B2M REGION
    Ralph Graff; Fiscal Year: 1990
    ..Objective: It is the long-term objective of this proposal to clarify biologic functions of the products of the B2m region, particularly their collaborative functions with the products of the MHC...
  14. HLA-G AND EQUIVALENT AND FETO-MATERNAL INTERACTION
    Hidde Ploegh; Fiscal Year: 2003
    ..of newly generated mice that lack expression of all classical Class I molecules, yet are fully proficient for B2m and TAP, to be crossed with HLA-G transgenic animals...
  15. A system to remove b2-microglobulin from blood
    Guillermo Ameer; Fiscal Year: 2007
    The overall goal of this proposal is to develop a blood detoxification system that is specific for b2-microglobulin (b2m), an amyloidgenic protein that has been implicated in dialysis-related amyloidosis (DRA)...
  16. Scale up and Characterization of Immunoadsorbent Ligands
    CYNTHIA DANIELS; Fiscal Year: 2006
    ..The major protein component found in the amyloid depositions is beta2- microglobulin (b2m), which is found on most nucleated cells...
  17. Fibrillogenesis pathways in diabetes and renal diseases
    ANDREW MIRANKER; Fiscal Year: 2007
    ..Second, renal diseases which necessitate treatment by dialysis result in the deposition of b-2 microglobulin (b2m) in the joints giving rise to a variety of skeletal pathologies...
  18. PURGING PROGENITOR CELL BY PULSED ELECTRIC FIELDS
    Abie Craiu; Fiscal Year: 2002
    ..quieseence/pluripotency assays, and in vivo hematopoietic reconstitution and malignancy assessment in NOD/SCIDt,B2m about mice...
  19. Bladder transcriptome in experimental inflammation
    Ricardo Saban; Fiscal Year: 2007
    ..Following target validation of SSH-selected genes, a custom array will be developed. This micro array will be used to determine how the bladder transcriptome is altered by BCG therapy. ..
  20. BECTON DICKINSON FACS CALIBUR 4 COLOR WITH SORT UNIT
    Kenneth Pollard; Fiscal Year: 2001
    ..Flow cytometry will be used to select and sort cell populations prior to and after transplantation studies. ..
  21. XENOBIOTIC ACCELERATION OF AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2003
    ..abstract_text> ..
  22. ROLE OF NON-CLASSICAL MHC CLASS I AND HSPs IN IMMUNITY
    Jacques Robert; Fiscal Year: 2009
    ..Do hsp70 and gp96 generate similar anti-tumor CCU-CTL effectors? Aim 3. How important is the hsp-generated CCU-CTL responses in tumor immunity in vivo? Aim 4. Do CCU-CTLs interact with class Ib molecules? ..
  23. Targeting myeloma via dendritic cells
    Madhav Dhodapkar; Fiscal Year: 2009
    ..abstract_text> ..
  24. IMMUNOTOXICOLOGY OF A HEAVY METAL
    Kenneth Pollard; Fiscal Year: 2004
    ..Analysis of the interaction between fibrillarin, mercury and cells of the lymphoid system may lead to insights into how an imunotoxin renders self-antigen immunogenic. ..
  25. Regulation of Vascular Calcification in Diabetes
    XUENING CHEN; Fiscal Year: 2007
    ....
  26. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2007
    ..Identification of the role that IFN-gamma plays in the development of induced murine systemic autoimmunity should prove applicable to murine models of idiopathic systemic autoimmunity and to human lupus. ..
  27. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2007
    ..Information generated by this study should elucidate whether bladder inflammatory responses, regardless of etiology, occur via a common mechanism or whether the endpoints are specific for each stimulus. ..
  28. Role of PIASy in Androgen Signaling and Prostate Cancer
    Mitchell Gross; Fiscal Year: 2006
    ..As a medical oncologist, the candidate?s career goal is to combine research in the fields of signal transduction and tumor biology to understand and treat prostate cancer...
  29. Urothelial Cell Physiology in Normal and Disease States
    Ricardo Saban; Fiscal Year: 2005
    ..Scott-Hultgren (Washington U) will discuss the molecular basis of persistent bladder infections. The bladder cancer discussion will be chaired by Drs. Robert Hurst (Oklahoma U) and Jenny Southgate (U. York). ..
  30. Middle Ear Epithelial Response to Cytokine Stimulation
    Joseph Kerschner; Fiscal Year: 2005
    ....