AVP

Summary

Gene Symbol: AVP
Description: arginine vasopressin
Alias: ADH, ARVP, AVP-NPII, AVRP, vasopressin-neurophysin 2-copeptin, antidiuretic hormone, copeptin, neurohypophyseal, prepro-AVP-NP II, prepro-arginine-vasopressin-neurophysin II, vasopressin-neurophysin II-copeptin
Species: human

Top Publications

  1. pmc Plasma carboxy-terminal provasopressin (copeptin): a novel marker of insulin resistance and metabolic syndrome
    Umer Saleem
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 94:2558-64. 2009
  2. pmc Endothelial markers may link kidney function to cardiovascular events in type 2 diabetes
    Christina Maier
    Department of Endocrinology, Medical University Hospital Vienna, Vienna, Austria
    Diabetes Care 32:1890-5. 2009
  3. doi Copeptin, a surrogate marker of vasopressin, is associated with microalbuminuria in a large population cohort
    Esther Meijer
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 77:29-36. 2010
  4. pmc Copeptin, IGFBP-1, and cardiovascular prognosis in patients with type 2 diabetes and acute myocardial infarction: a report from the DIGAMI 2 trial
    Linda G Mellbin
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Diabetes Care 33:1604-6. 2010
  5. pmc Plasma copeptin and the risk of diabetes mellitus
    Sofia Enhörning
    Department of Clinical Sciences, Lund University, Clinical Research Center, Entrance 72, Bldg 91, Floor 12, Malmo University Hospital, SE 20502 Malmo, Sweden
    Circulation 121:2102-8. 2010
  6. doi Copeptin in heart transplant recipients depends on kidney function and intraventricular septal thickness
    P Przybylowski
    Department of Cardiovascular Surgery and Transplantology, Jagiellonian University, John Paul II Hospital, Cracow, Poland
    Transplant Proc 42:1808-11. 2010
  7. doi Plasma copeptin, a unifying factor behind the metabolic syndrome
    Sofia Enhörning
    Department of Clinical Science, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    J Clin Endocrinol Metab 96:E1065-72. 2011
  8. pmc Comparison of the temporal release pattern of copeptin with conventional biomarkers in acute myocardial infarction
    Youlan L Gu
    Department of Cardiology, Thorax Center, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, 9700 RB, Groningen, The Netherlands
    Clin Res Cardiol 100:1069-76. 2011
  9. doi The contributions of oxytocin and vasopressin pathway genes to human behavior
    Richard P Ebstein
    Department of Psychology, National University of Singapore, Singapore
    Horm Behav 61:359-79. 2012
  10. doi C-terminal provasopressin (copeptin) is associated with left ventricular dysfunction, remodeling, and clinical heart failure in survivors of myocardial infarction
    Dominic Kelly
    Department of Cardiovascular Sciences, University of Leicester, UK
    J Card Fail 14:739-45. 2008

Research Grants

  1. Neurodevelopmental Mechanisms of Social Behavior
    PAT R LEVITT; Fiscal Year: 2011
  2. JOSEPH D WALCH; Fiscal Year: 2014
  3. Neural Control of Vasopressin Release
    J Thomas Cunningham; Fiscal Year: 2013
  4. DEPOLARIZATION-SECRETION COUPLING IN NERVE TERMINALS
    Jose R Lemos; Fiscal Year: 2012
  5. Mohammad Al-Bataineh; Fiscal Year: 2015
  6. Vicente E Torres; Fiscal Year: 2016
  7. A Potential New Drug for Depression
    EVE DAMIANO; Fiscal Year: 2009
  8. Neuropeptide regulation of neurohypophyseal function
    Francis W Flynn; Fiscal Year: 2012
  9. Dennis Brown; Fiscal Year: 2016
  10. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013

Detail Information

Publications484 found, 100 shown here

  1. pmc Plasma carboxy-terminal provasopressin (copeptin): a novel marker of insulin resistance and metabolic syndrome
    Umer Saleem
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 94:2558-64. 2009
    Stress-mediated hypothalamic-pituitary-adrenal axis activation, regulated by arginine vasopressin (AVP), may have a role in the pathophysiology of metabolic syndrome (MetSyn).
  2. pmc Endothelial markers may link kidney function to cardiovascular events in type 2 diabetes
    Christina Maier
    Department of Endocrinology, Medical University Hospital Vienna, Vienna, Austria
    Diabetes Care 32:1890-5. 2009
    ..The aim of this study was to investigate the role of stable fragments of the precursors of adrenomedullin, endothelin-1, vasopressin, and atrial natriuretic peptide in progression of cardiovascular disease in patients with diabetes...
  3. doi Copeptin, a surrogate marker of vasopressin, is associated with microalbuminuria in a large population cohort
    Esther Meijer
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 77:29-36. 2010
    ..To determine this we measured copeptin, a marker of endogenous vasopressin levels, and its association with urinary albumin excretion in 7593 patients ..
  4. pmc Copeptin, IGFBP-1, and cardiovascular prognosis in patients with type 2 diabetes and acute myocardial infarction: a report from the DIGAMI 2 trial
    Linda G Mellbin
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Diabetes Care 33:1604-6. 2010
    To determine whether C-terminal provasopressin (copeptin) explains the prognostic importance of insulin growth factor binding protein-1 (IGFBP-1) in patients with myocardial infarction and type 2 diabetes.
  5. pmc Plasma copeptin and the risk of diabetes mellitus
    Sofia Enhörning
    Department of Clinical Sciences, Lund University, Clinical Research Center, Entrance 72, Bldg 91, Floor 12, Malmo University Hospital, SE 20502 Malmo, Sweden
    Circulation 121:2102-8. 2010
    ..Animal studies suggest that the arginine vasopressin system may play a role in glucose metabolism, but data from humans are limited...
  6. doi Copeptin in heart transplant recipients depends on kidney function and intraventricular septal thickness
    P Przybylowski
    Department of Cardiovascular Surgery and Transplantology, Jagiellonian University, John Paul II Hospital, Cracow, Poland
    Transplant Proc 42:1808-11. 2010
    Copeptin is cosynthesized with vasopressin, also known as antidiuretic hormone, with plasma levels similar to vasopressin...
  7. doi Plasma copeptin, a unifying factor behind the metabolic syndrome
    Sofia Enhörning
    Department of Clinical Science, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    J Clin Endocrinol Metab 96:E1065-72. 2011
    ..We previously showed that high copeptin, the stable C-terminal fragment of AVP prohormone, is independently associated with hyperinsulinemia and future ..
  8. pmc Comparison of the temporal release pattern of copeptin with conventional biomarkers in acute myocardial infarction
    Youlan L Gu
    Department of Cardiology, Thorax Center, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, 9700 RB, Groningen, The Netherlands
    Clin Res Cardiol 100:1069-76. 2011
    ..We aimed to compare the temporal release pattern of the C-terminal portion of provasopressin (copeptin) with conventional cardiac biomarkers, including creatine kinase isoenzyme (CK-MB), cardiac troponin T (cTnT), ..
  9. doi The contributions of oxytocin and vasopressin pathway genes to human behavior
    Richard P Ebstein
    Department of Psychology, National University of Singapore, Singapore
    Horm Behav 61:359-79. 2012
    Arginine vasopressin (AVP) and oxytocin (OXT) are social hormones and mediate affiliative behaviors in mammals and as recently demonstrated, also in humans...
  10. doi C-terminal provasopressin (copeptin) is associated with left ventricular dysfunction, remodeling, and clinical heart failure in survivors of myocardial infarction
    Dominic Kelly
    Department of Cardiovascular Sciences, University of Leicester, UK
    J Card Fail 14:739-45. 2008
    ..Arginine vasopressin is elevated in heart failure and the C-terminal of provasopressin (Copeptin) is associated with adverse outcome post-AMI...
  11. doi Plasma levels of copeptin in patients with coronary heart disease
    San Bao Chai
    Department of Cardiovascular Disease, Beijing Fengtai Hospital, Beijing, PR China
    Heart Vessels 24:79-83. 2009
    The present study was undertaken to investigate alteration in plasma levels of copeptin, a stable fragment derived from provasopressin, in patients with coronary heart disease...
  12. pmc Copeptin, a surrogate marker for arginine vasopressin, is associated with cardiovascular and all-cause mortality in patients with type 2 diabetes (ZODIAC-31)
    Ineke J Riphagen
    Corresponding author Ineke J Riphagen
    Diabetes Care 36:3201-7. 2013
    b>Copeptin, a surrogate marker for arginine vasopressin, has been associated with cardiovascular (CV) events and mortality in patients with type 2 diabetes complicated by end-stage renal disease or acute myocardial infarction...
  13. ncbi Two families with hereditary diabetes insipidus not due to osmoreceptor failure
    F Laczi
    1st Department of Medicine, , Szeged, Hungary
    Horm Metab Res 24:70-2. 1992
    ..The pedigree in both families shows an autosomal dominant trait. The plasma arginine-8-vasopressin (AVP) determined by radioimmunoassay was markedly lower in these CDI patients than in healthy controls; the difference ..
  14. ncbi Assessing viral gene therapy in neuroendocrine models
    B J Geddes
    Department of Medicine Laboratories, University of Bristol, United Kingdom
    Front Neuroendocrinol 20:296-316. 1999
    ..Brattleboro rats contain a point mutation in the arginine vasopressin (AVP) gene that results in a pathological phenotype characterized by a lack of circulating AVP...
  15. ncbi Diabetes insipidus secondary to penetrating spinal cord trauma: case report and literature review
    K Kuzeyli
    Department of Neurosurgery, Karadeniz Technical University Medical Faculty, Trabzon, Turkey
    Spine (Phila Pa 1976) 26:E510-1. 2001
    ..SUMMARY OF BACKGROUND DATA: Antidiuretic hormone (ADH) abnormalities may develop after spinal trauma and/or surgery...
  16. ncbi [Diabetes insipidus in sarcoidosis]
    B Fischer
    III. Medizinische Klinik, Schwerpunkt Pneumologie,
    Pneumologie 45:100-4. 1991
    ..Intranasal administration of synthetic antidiuretic hormone (ADH) reduced urine volume to normal levels immediately...
  17. ncbi Long-term gene therapy in the CNS: reversal of hypothalamic diabetes insipidus in the Brattleboro rat by using an adenovirus expressing arginine vasopressin
    B J Geddes
    University of Bristol, Department of Medicine Laboratories, UK
    Nat Med 3:1402-4. 1997
    ..In the present study, we have used an Ad encoding the arginine vasopressin cDNA (AdAVP) in an AVP-deficient animal model of diabetes insipidus (the Brattleboro rat), which allowed us to monitor chronically the ..
  18. pmc Effects of omega-conotoxin on adrenergic, cholinergic and NANC neurotransmission in the rabbit urethra and detrusor
    P M Zygmunt
    Department of Clinical Pharmacology, University of Lund, Sweden
    Br J Pharmacol 110:1285-90. 1993
    ..2. EFS induced a relaxation in urethral smooth muscle and lamina propria precontracted by arginine vasopressin (AVP)...
  19. ncbi Inhibitors of Na-K-ATPase in human urine: effects of ouabain-like factors and of vanadium-diascorbate on calcium mobilization in rat vascular smooth muscle cells: comparison with the effects of ouabain, angiotensin II, and arginine-vasopressin
    H Meyer-Lehnert
    Renal Section, Medical Policlinic, University of Bonn, Germany
    Am J Hypertens 13:364-9. 2000
    ..smooth muscle (VSM) cells in comparison to the effects of ouabain, angiotensin II (A II), and arginine-vasopressin (AVP). [Ca2+]i was determined by the fura-2 method...
  20. pmc Relaxation of human isolated mesenteric arteries by vasopressin and desmopressin
    M C Martinez
    Departamento de Fisiologia, Universidad de Valencia, Spain
    Br J Pharmacol 113:419-24. 1994
    ..59 +/- 0.12 nM. The V1 antagonist d(CH2)5Tyr(Me)AVP (1 microM) and the mixed V1-V2 antagonist desGly-d(CH2)5D-Tyr(Et)ValAVP (0...
  21. pmc Central administration of 5-HT activates 5-HT1A receptors to cause sympathoexcitation and 5-HT2/5-HT1C receptors to release vasopressin in anaesthetized rats
    I K Anderson
    Academic Department of Pharmacology, Royal Free Hospital School of Medicine, Hampstead, London
    Br J Pharmacol 107:1020-8. 1992
    ..antagonist, beta-mercapto-beta,beta-cyclopentamethylene-propionyl1, O-Me-Tyr2, Arg8-vasopressin [(d(CH2)5Tyr(Me)AVP, 10 micrograms kg-1, i.v...
  22. ncbi Prolonged exercise following diuretic-induced hypohydration effects on fluid and electrolyte hormones
    B D Roy
    Department of Kinesiology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1 Canada
    Horm Metab Res 33:540-7. 2001
    ..26 +/- 0.03 vs. 0.56 +/- 0.08 ng/ml), aldosterone (ALD) (143 +/- 14 vs. 1603 +/- 302 pg/ml), arginine vasopressin (AVP) (4.13 +/- 1.1 vs. 9.58 +/- 1.6 pg/ml) and atrial natriuretic peptide (alpha-ANP) (11.5 +/- 2.8 vs. 6.33 +/- 1...
  23. pmc Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by three selective type-4 phosphodiesterase inhibitors: in vitro and in vivo studies
    M Kumari
    Department of Pharmacology, Charing Cross and Westminister Medical School, London
    Br J Pharmacol 121:459-68. 1997
    ..05). None of the drugs tested, alone or in combination, modified the release of arginine vasopressin (ir-AVP) from the hypothalamus. 4...
  24. ncbi [Activation mechanisms by thrombin and vasopressin of fibroblasts in spontaneously hypertensive rats]
    P Marche
    Groupe INSERM de pharmacologie vasculaire, , Paris
    Arch Mal Coeur Vaiss 84:1243-5. 1991
    ..C, protein kinase C and GTP-binding proteins (G-proteins), in response to thrombin or arginin-vasopressin (AVP)...
  25. pmc Mechanism of bile salt vasoactivity: dependence on calcium channels in vascular smooth muscle
    J M Pak
    Liver Unit, University of Calgary Faculty of Medicine, AB Canada
    Br J Pharmacol 112:1209-15. 1994
    ..5. Contractions induced by KCl (0.01-1.0 M), arginine vasopressin (AVP, 10(-10)-10(-7) M) or cirazoline (10(-7) x 10(-5) M) were all inhibited by TDC (300 microM). 6...
  26. pmc Mechanisms of vasodilatation in pregnancy: studies of the role of prostaglandins and nitric-oxide in changes of vascular reactivity in the in situ blood perfused mesentery of pregnant rats
    Z M Chu
    University of Western Australia, Department of Medicine, Perth
    Br J Pharmacol 109:322-9. 1993
    ..to electrical stimulation (ES) or intra-arterial noradrenaline (NA), angiotensin II (AII) and arginine vasopressin (AVP) was decreased in the preparations from pregnant rats compared to that from nonpregnant controls...
  27. ncbi [Neurohormonal profile in aortic valve stenosis]
    J F Ramirez-Gil
    Service de cardiologie, , Paris
    Arch Mal Coeur Vaiss 86:1001-7. 1993
    ..Plasma concentrations of endothelin 1, atrial natriuretic factor (ANF), arginine vasopressin (AVP), catecholamines, plasma renin activity (PRA), angiotensin II and aldosterone were measured in resting, fasting ..
  28. pmc Differential effects of phosphoramidon on contractile responses to angiotensin II in rat blood vessels
    L Chen
    Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, 0W0, Canada
    Br J Pharmacol 114:1599-604. 1995
    ..response (C-R) curves to angiotensin II (AII), big endothelin-1 (big ET-1), ET-1 and arginine vasopressin (AVP) were determined in endothelium intact-ring preparations of aorta, mesenteric artery and tail artery isolated from ..
  29. ncbi Vasopressin V(2)-receptor-dependent regulation of AQP2 expression in Brattleboro rats
    D Promeneur
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, Denmark
    Am J Physiol Renal Physiol 279:F370-82. 2000
    The role of AVP-V(2) receptor (AVP-V(2)R)-dependent regulation of aquaporin-2 (AQP2) expression was evaluated in vasopressin-deficient Brattleboro (BB) rats...
  30. ncbi Effects of urinary ouabain-like factors and vanadium diascorbate on calcium mobilization in porcine inner medullary collecting duct cells: comparison with the effects of ouabain and vasopressin
    H J Kramer
    The Renal Section, Medical Policlinic, University of Bonn, Germany
    Am J Hypertens 11:1208-13. 1998
    ..the effects of urinary OLF-1 and OLF-2, and of vanadium diascorbate in comparison to ouabain and vasopressin (AVP) on calcium mobilization, ie, on free calcium concentration [Ca2+]i, in cultured porcine IMCD cells...
  31. ncbi Characteristics of endothelin receptors and intracellular signalling in porcine inner medullary collecting duct cells
    I Migas
    Renal Section, University of Bonn, Germany
    Am J Hypertens 6:611-8. 1993
    ..ET-1 slightly suppressed basal and significantly attenuated arginine vasopressin (AVP)-induced cyclic adenosine monophosphate (cAMP) synthesis...
  32. ncbi Changes in physiological and neuroendocrine properties during thermal adaptation of golden hamsters (Mesocricetus auratus)
    J Roth
    Physiologisches Institut, Giessen, Federal Republic of Germany
    J Comp Physiol B 160:153-9. 1990
    ..group of golden hamsters the brains were processed for immunocytochemical detection of arginine-vasopressin (AVP) and corticotropin releasing factor (CRF) in the third week of adaptation to a cold or warm environment...
  33. ncbi Excitatory action of the bird antidiuretic hormone vasotocin on neurons in the subfornical organ
    H A Schmid
    , W G Kerckhoff Institut, Bad Nauheim, Germany
    J Comp Physiol A 176:653-60. 1995
    ..neurons in the subfornical organ (SFO) of adult ducks to angiotensin II (ANGII) and the bird specific antidiuretic hormone, arginine vasotocin (AVT), the analog of the mammalian arginine vasopressin (AVP), were investigated in ..
  34. ncbi Contribution of vasopressin to orthostatic blood pressure maintenance in essential hypertension
    R B de Paula
    Nephrology Division, Escola Paulista de Medicina, Sao Paulo, Brazil
    Am J Hypertens 6:794-8. 1993
    Arginine vasopressin (AVP) has been found to participate in blood pressure maintenance especially when other pressor systems are endogenously or pharmacologically impaired...
  35. ncbi Postpartum abnormalities of carbohydrate and cellular calcium metabolism in pregnancy induced hypertension
    J R Sowers
    Division of Endocrinology, Hypertension, and Metabolism, Wayne State University School of Medicine, Detroit, Michigan 48201
    Am J Hypertens 6:302-7. 1993
    ..g) on plasma and glucose insulin, basal platelet [Ca2+]i and platelet [Ca2+]i responses to arginine vasopressin (AVP)...
  36. ncbi The vasopressin-like immunoreactive (VPLI) neurons of the locust, Locusta migratoria. II. Physiology
    K S Thompson
    School of Biological Sciences, University of Sussex, Brighton, UK
    J Comp Physiol A 168:619-30. 1991
    ..One of the two peptides responsible for AVP-like immunoreactivity is a vasopressin-related peptide with putative 'diuretic hormone' properties...
  37. ncbi Acute plasma volume expansion in the untrained alters the hormonal response to prolonged moderate-intensity exercise
    B D Roy
    Dept. of Kinesiology, University of Waterloo, ON, Canada
    Horm Metab Res 33:238-45. 2001
    ..2% increase (p<0.05) in PV. The prolonged exercise resulted in increases (p<0.05) in plasma vasopressin (AVP), plasma rennin activity (PRA), aldosterone (ALD), atrial naturetic peptide (alpha-ANP), and the catecholamines ..
  38. pmc Corticosterone differentially modulates expression of corticotropin releasing factor and arginine vasopressin mRNA in the hypothalamic paraventricular nucleus following either acute or repeated restraint stress
    S B Pinnock
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY UK
    Eur J Neurosci 13:576-84. 2001
    ..adaptations in the expression of either corticotropin-releasing factor (CRF) or arginine-vasopressin (AVP) mRNA in the parvocellular neurons of the hypothalamic paraventricular nucleus (PVN)...
  39. ncbi Altered angiotensin II-induced small artery contraction during the development of hypertension in spontaneously hypertensive rats
    D Endemann
    MRC Multidisciplinary Research Group on Hypertension, , , , Canada
    Am J Hypertens 12:716-23. 1999
    ..whether effects were specific for Ang II, contractile responses to another vasoactive agonist, vasopressin (AVP), were also determined. Systolic blood pressure was measured in conscious rats by the tail-cuff method...
  40. ncbi Regulation of cAMP-sensitive colonic epithelial Na+ channel in oocyte expression system
    M Schnizler
    , Germany
    J Comp Physiol B 171:369-75. 2001
    In amphibian epithelia and in cortical collecting duct the antidiuretic peptide arginine-vasopressin (AVP) stimulates activity of epithelial Na+ channels (ENaCs)...
  41. ncbi Release of prolactin as well as adrenocorticotropin after administration of arginine-vasopressin to healthy men
    E M Erfurth
    Department of Internal Medicine, University Hospital, Lund, Sweden
    Horm Metab Res 28:599-602. 1996
    ..v. injection of arginine-vasopressin (AVP)...
  42. ncbi Impaired recovery of vascular smooth muscle intracellular calcium following agonist stimulation in insulin resistant (Zucker obese) rats
    M A Abel
    Department of Physiology Program, University of Tennessee, Knoxville 37996-1900
    Am J Hypertens 6:500-4. 1993
    ..The [Ca2+]i responses to and rate of recovery from angiotensin II (AII; 200 nmol/L) and arginine vasopressin (AVP; 10 mumol/L) were studied fluorometrically in stirred suspension (10(6) cells/mL)...
  43. ncbi Increased platelet cytosolic calcium responses to low density lipoprotein in type II diabetes with and without hypertension
    P R Standley
    Division of Endocrinology and Hypertension, Wayne State University, School of Medicine, Detroit, MI 48201
    Am J Hypertens 6:938-43. 1993
    ..In this study we have evaluated platelet [Ca2+]i responsiveness to LDL and arginine vasopressin (AVP) in NIDDM patients with (n = 28) and without (n = 13) concomitant hypertension, as well as in normal nondiabetic ..
  44. pmc Effect of dehydration and hyperosmolal hydration on lignocaine and metabolites disposition in conscious rabbits
    M Chamelian
    Department of Pharmacology, School of Medicine, , , Canada
    Br J Pharmacol 113:317-23. 1994
    ..In dehydrated animals, baseline values of plasma arginine vasopressin (AVP) concentrations and plasma renin activity (PRA) were higher than in controls, i.e. 12.4 +/- 1.4 pg ml-1 and 15...
  45. ncbi Regulation of the urinary excretion of endothelin in the rat
    Z A Abassi
    Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    Am J Hypertens 6:453-7. 1993
    ..The present study was designed to examine the effect of angiotensin II (A-II), arginine vasopressin (AVP), and nifedipine on UETV...
  46. ncbi Determinants of platelet intracellular free calcium in essential hypertension and effect of stimulation by arginine vasopressin
    M A Miller
    Department of Physiological Medicine, St. George's Hospital Medical School, London, England
    Am J Hypertens 6:209-16. 1993
    ..free calcium response to agonist stimulation was measured in the presence of 1 mumol/L arginine vasopressin (AVP)...
  47. ncbi Endothelin synthesis by porcine inner medullary collecting duct cells. Effects of hormonal and osmotic stimuli
    I Migas
    Renal Section, University of Bonn, Germany
    Am J Hypertens 8:748-52. 1995
    ..duct (IMCD) cells that endothelin (ET), probably in an autocrine fashion, suppresses arginine vasopressin (AVP)-induced synthesis of cAMP and thereby, may modify the action of AVP on IMCD fluid transport...
  48. ncbi Divergent effects of acute and chronic ethanol exposure on contraction and Ca2+ mobilization in cultured vascular smooth muscle cells
    V A Briner
    Department of Medicine, University of Colorado School of Medicine, Denver 80262
    Am J Hypertens 6:268-75. 1993
    ..ethanol for 30 min attenuated the number of contracting cells in response to (10(-7) mol/L) arginine vasopressin (AVP) (P < .01)...
  49. ncbi Interleukin-1 potentiates basal and AVP-stimulated ACTH secretion in vitro--the role of CRH pre-incubation
    W J Inder
    Department of Endocrinology, Christchurch Hospital, New Zealand
    Horm Metab Res 32:350-4. 2000
    ..02 nM CRH and 100 nM cortisol. Columns were given a 5-minute pulse of arginine vasopressin (AVP, 10 nM), perifused for 4 hours with 0 (control) or 1 nM IL-1beta, then given a further 5-minute pulse of AVP (10nM)...
  50. ncbi Arginine vasopressin infusion increases plasma levels of atrial natriuretic factor in humans
    A Cases
    Nephrology Department, , Barcelona, Catalonia, Spain
    Horm Metab Res 24:127-9. 1992
    Seven normal subjects underwent sequential 20-min infusion of arginine vasopressin (AVP) at 0.5 and 2 ng/(kg...
  51. doi V2R mutations and nephrogenic diabetes insipidus
    Daniel G Bichet
    Canada Research Chair in Genetics of Renal Diseases, Groupe d étude des protéines membranaires, Montreal, Quebec, Canada
    Prog Mol Biol Transl Sci 89:15-29. 2009
    ..characterized by an inability to concentrate urine despite normal or elevated plasma concentrations of the antidiuretic hormone, arginine vasopressin (AVP)...
  52. ncbi Central effects of angiotensin II in conscious hamsters: drinking, pressor response, and release of vasopressin
    R Rettig
    Department of Medicine, University of California, San Diego, La Jolla 92093
    J Comp Physiol B 158:703-9. 1989
    ..injections of angiotensin II (ANG II) on water intake, blood pressure, heart rate, and plasma arginine-vasopressin (AVP) concentration were studied in chronically instrumented adult male Syrian golden hamsters (Mesocricetus auratus)...
  53. ncbi Arginine vasopressin response to insulin-induced hypoglycemia in insulin-dependent diabetics with asymptomatic hypoglycemia
    J P Wolf
    , , Centre Hospitalier Universitaire Jean Minjoz, , France
    Horm Metab Res 22:232-6. 1990
    Insulin-induced hypoglycemia causes an increase in plasma vasopressin (AVP) in healthy subjects but the response in diabetics is not established...
  54. ncbi Chronic pressure-natriuresis relationship in dogs with inherited essential hypertension
    P E Papanek
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226
    Am J Hypertens 6:960-7. 1993
    ..for analysis of plasma renin activity (PRA), atrial natriuretic peptide (ANP), aldosterone (ALDO), and vasopressin (AVP)...
  55. ncbi The cellular mechanism of action by vasoconstrictor hormones in cultured rat vascular smooth muscle cells
    S Takata
    Department of Medicine, Kobe University School of Medicine, Japan
    Am J Hypertens 3:227S-230S. 1990
    The effects of angiotensin (Ang) II, arginine vasopressin (AVP), and serotonin (5-HT) on inositol trisphosphate (IP3) production, cytosolic Ca2+ concentration [( Ca2+]i), and the phosphorylation of 20 kilodalton myosin light chain (MLC) ..
  56. ncbi Different vascular responses to subpressor angiotensin II administration in the mesenteric and renal circulation of rats
    G Cserep
    Department of Medicine, VA Medical Center, Minneapolis, Minnesota 55417, USA
    Am J Hypertens 9:385-92. 1996
    ..Vascular responses to ANG II, norepinephrine (NE), arginine vasopressin (AVP) and nerve stimulation were measured in the mesenteric and renal circulation of rats...
  57. ncbi Effects of estradiol and progesterone on platelet calcium responses
    B B Raman
    Department of Medicine, Wayne State University, Detroit, Michigan, USA
    Am J Hypertens 8:197-200. 1995
    ..of 17 beta-estradiol (beta E2), alpha-estradiol (alpha E2), and progesterone (P) on baseline and vasopressin (AVP)-induced [Ca2+]i in human platelets obtained from healthy male and female volunteers...
  58. ncbi Effects of high altitude exposure on plasma and urinary digoxin-like immunoreactive substance
    C De Angelis
    Italian Air Force, D.A.S.R.S.-Aerospace Medicine Department, Aeroporto Pratica Di Mare Rome
    Am J Hypertens 5:600-7. 1992
    ..studied DLIS, plasma renin activity (PRA), aldosterone, atrial natriuretic peptide (ANP), and arginine vasopressin (ADH) in serial blood and urine samples. An increase in DLIS in plasma (P less than .005) and urine (P less than ...
  59. ncbi Antihypertensive effects of 2-octynyladenosine (YT-146), a selective adenosine A2 receptor agonist, in Dahl salt-sensitive rats
    T Iwamoto
    Second Department of Internal Medicine, Yokohama City University School of Medicine, Japan
    Am J Hypertens 7:984-8. 1994
    ..YT-146 had no effect on plasma renin activity (PRA), plasma aldosterone, vasopressin (ADH), and atrial natriuretic peptide (ANP) in the acute study.(ABSTRACT TRUNCATED AT 250 WORDS)
  60. ncbi Prevention of invasive breast cancer in women with ductal carcinoma in situ: an update of the National Surgical Adjuvant Breast and Bowel Project experience
    B Fisher
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA
    Semin Oncol 28:400-18. 2001
    ..demonstrated a 50% reduction in the risk of invasive cancer in women with a history of atypical ductal hyperplasia (ADH) or lobular carcinoma in situ (LCIS) and a reduction in the incidence of both DCIS and LCIS in women without a ..
  61. ncbi Withdrawal-induced antihypertensive effect of vasopressin in Doca-salt hypertension
    E K Chiu
    Department of Pharmacology, University of Saskatchewan, Saskatoon, Canada
    Am J Hypertens 2:458-61. 1989
    ..of conscious unrestrained rats before, during and after a three-hour intravenous infusion of arginine vasopressin (AVP; 20 ng/kg/min). Before infusion of AVP, basal arterial pressure was 152 +/- 3...
  62. ncbi Inhibition by (-)-cicletanine of the vascular reactivity to angiotensin II and vasopressin in isolated rat vessels
    F Vargas
    Department of Physiology (FV, School of Medicine of Granada, Spain
    Am J Hypertens 11:579-84. 1998
    ..reduces the pressor responses to angiotensin II (AII) and also, to a lesser extent, those to arginine-vasopressin (AVP)...
  63. ncbi Influence of hypertonic monosaccharide infusions on the release of plasma arginine vasopressin in normal humans
    J P Wolf
    , , Centre Hospitalier Universitaire Jean Minjoz, , France
    Horm Metab Res 24:379-83. 1992
    ..the osmotic efficiency of hypertonic monosaccharide solutes on the release of plasma arginine vasopressin (AVP). Twenty percent hypertonic glucose infused at 0.187 mmol/kg body weight/min. over 15 min...
  64. ncbi Influence of sodium and potassium diets on adrenal vasopressin content and direct effects of vasopressin on aldosterone synthesis in adrenocortical cells
    V Bahr
    Abteilung Endokrinologie, Medizinische Klinik, Klinikum Steglitz, Freie Universitat, Berlin, Germany
    Horm Metab Res 25:411-6. 1993
    Two questions were investigated to elucidate the adrenal function of arginine vasopressin (AVP) in controlling aldosterone secretion: Are vasopressin tissue concentrations in the adrenal modulated by diets that influence aldosterone ..
  65. ncbi Effects of alpha-2 adrenoreceptor blockade by yohimbine on the hormonal response to hypoglycaemic stress in normal man
    R C Cuneo
    Department of Endocrinology, Princess Margaret Hospital, Christchurch, New Zealand
    Horm Metab Res 21:33-6. 1989
    ..05), no change was observed in basal or stimulated plasma ACTH, cortisol, arginine vasopressin (AVP) or prolactin responses following yohimbine...
  66. ncbi A novel heterozygous missense mutation in the vasopressin moiety is identified in a Japanese person with neurohypophyseal diabetes insipidus
    H Kobayashi
    Department of Endocrinology, Kobe City General Hospital, 4 6, Minatojimanakamachi, Hyogo, 650 0046 Japan
    J Endocrinol Invest 29:252-6. 2006
    The autosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI) is caused by diverse mutations in one allele of the gene that encodes the arginine vasopressin (AVP) precursor protein, AVP-neurophysin II (AVP-NP II)...
  67. ncbi [Two cases of infantile autism with intermittent water intoxication due to compulsive water drinking and episodic release of antidiuretic hormone (SIADH)]
    M Hiratani
    Department of Pediatrics, Center of Developmental Medicine and Education for Handicapped Children, Fukui Prefecture
    No To Hattatsu 29:367-72. 1997
    ..Laboratory data showed inappropriately high serum ADH level (8...
  68. ncbi Immunoreactive vasopressin in bull seminal fluid
    S Lundin
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Horm Metab Res 19:629-31. 1987
    ..On reversed phase HPLC the extracted material coeluted with synthetic AVP. These findings suggest an identity of this immunoreactive material with intact AVP...
  69. ncbi Contributions of the kidneys and intestines to water conservation, and plasma levels of antidiuretic hormone, during dehydration in house sparrows (Passer domesticus)
    D L Goldstein
    Department of Physiology, University of Arizona, Tucson 85724
    J Comp Physiol B 158:353-61. 1988
    ..That is, urine undergoes significant post-renal modification in hydrated but not dehydrated house sparrows...
  70. ncbi Proconvulsive effect of vasopressin; mediation by a putative V2 receptor subtype in the central nervous system
    G Croiset
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, Netherlands
    Brain Res 759:18-23. 1997
    Subcutaneously (s.c.) administered [Arg8]vasopressin (AVP) potentiated seizures induced by intracerebroventricular (i.c.v.) injection of 1.95 mg pilocarpine (a muscarinic cholinergic agonist)...
  71. ncbi Failure to demonstrate natriuretic activity in the posterior pituitary after immunoneutralization of the vasopressin content
    J Ponec
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Czechoslovakia
    Horm Metab Res 23:473-5. 1991
    ..to demonstrate the presence of a natriuretic substance in the posterior pituitary after immunoneutralization of the AVP content failed. Rats infused i.v...
  72. ncbi A V1-vascular vasopressin antagonist suitable for radioiodination and photoaffinity labeling
    M Thibonnier
    Department of Medicine, University Hospital of Cleveland, Case Western Reserve University School of Medicine, Ohio 44106
    Am J Hypertens 3:471-5. 1990
    We have previously characterized the V1-vascular arginine vasopressin (AVP) receptors of human platelets (Thibonnier M, J Biol Chem 1987;262: 10960-10964)...
  73. ncbi Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands
    C Serradeil-Le Gal
    Exploratory Research Department, Sanofi Synthelabo Recherche, 195 Route d Espagne 31036 Toulouse, France
    Prog Brain Res 139:197-210. 2002
    ..blockade could be of interest in several water-retaining diseases such as the syndrome of inappropriate antidiuretic hormone secretion (SIADH), liver cirrhosis and congestive heart failure and deserves to be widely explored...
  74. ncbi [Classification of alcohol metabolizing enzymes and polymorphisms--specificity in Japanese]
    S Harada
    Institute of Community Medicine, University of Tsukuba, Tennoudai 1 1 1, Tsukuba City, Ibaraki, Japan 305 8575
    Nihon Arukoru Yakubutsu Igakkai Zasshi 36:85-106. 2001
    Multiple forms and gene loci of human alcohol dehydrogenase (ADH EC: 1.2.1.3) and aldehyde dehydrogenase (ALDH, EC: 1.2.1.3) in the major pathway of alcohol metabolism have been found and characterized in the last two decades...
  75. ncbi Cutaneous metabolism of glycol ethers
    David J Lockley
    Skin Toxicology Group, Department of Environmental and Occupational Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    Arch Toxicol 79:160-8. 2005
    ..with their oxidation to the corresponding aldehyde and alkoxyacetic acid by cytosolic alcohol dehydrogenase (ADH; EC 1.1.1.1.) and aldehyde dehydrogenase (ALDH; 1.2.1.3)...
  76. ncbi Maternal and fetal hypothalamic-pituitary-adrenal axes during pregnancy and postpartum
    George Mastorakos
    2nd Department of Obstetrics and Gynecology, Medical School, University of Athens, Aretaieion Hospital, Athens, Greece
    Ann N Y Acad Sci 997:136-49. 2003
    ..the hypothalamic-pituitary-adrenal (HPA) axis are corticotropin-releasing hormone (CRH) and arginine-vasopressin (AVP). Corticotropin-releasing hormone is not exclusively produced in the hypothalamus...
  77. ncbi Osmoregulatory responses of glucous-winged gulls (Larus glaucescens) to dehydration and hemorrhage
    M R Hughes
    Department of Zoology, University of British Columbia, Vancouver, Canada
    J Comp Physiol B 163:524-31. 1993
    The effects of dehydration and hemorrhage on plasma ionic, osmotic, and antidiuretic hormone (arginine vasotocin) concentrations and of hemorrhage on salt gland secretion and glomerular filtration rate were evaluated in glaucous-winged ..
  78. ncbi Influence of arginine vasopressin receptors and angiotensin receptor subtypes on the water intake and arterial blood pressure induced by vasopressin injected into the lateral septal area of the rat
    Wilson Abrão Saad
    Department of Physiology, School of Dentistry Paulista, State University, UNESP, Araraquara, SP, Brazil
    Auton Neurosci 111:66-70. 2004
    ..antagonist, injected into the lateral septal area (LSA) on thirst and hypertension induced by [Arg8]vasopressin (AVP). AAVP and ATAVP injected into the LSA reduced the drinking responses elicited by injecting AVP into the LSA...
  79. ncbi Vasotocin acts as a dipsogen in ducks at concentrations stimulating subfornical organ neurons in vitro
    H A Schmid
    Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    J Comp Physiol B 165:615-21. 1996
    The effects of systemic infusions of the avian antidiuretic hormone arginine vasotocin on water intake of domestic ducks were investigated under steady conditions of water balance in which angiotensin II was effective as a dipsogen...
  80. ncbi Influence of insulin on plasma concentration and renal excretion of sodium and potassium in normal, electrolytes depleted and aldosterone treated dogs
    M Bak
    Department of Gastroenterology and Metabolic Diseases, Medical Academy, Warsaw, Poland
    Horm Metab Res 19:470-4. 1987
    ..Repeated loading with mannitol in Series 2 elicited significant elevation of plasma sodium, ADH and aldosterone concentrations, as well as decrease in extracellular fluid volume...
  81. ncbi Separate receptors mediate oxytocin and vasopressin stimulation of cAMP in rat inner medullary collecting duct cells
    E T Wargent
    School of Biological Sciences, University of Manchester, UK
    Exp Physiol 84:17-25. 1999
    The two neurohypophysial hormones arginine vasopressin (AVP) and oxytocin have actions in the inner medullary collecting duct (IMCD) where both peptides induce an increase in cAMP accumulation...
  82. ncbi In situ carcinomas of the female breast. Incidence, clinical findings and DBCG proposals for management
    H P Graversen
    Department of Surgery, Odense University Hospital, Denmark
    Acta Oncol 27:679-82. 1988
    ..associated are controversial forms of epithelial hyperplasia, lobular cell atypia (ALH) and ductal cell atypia (ADH)...
  83. ncbi Arginine vasopressin stimulates proliferation of adult rat cardiac fibroblasts via protein kinase C-extracellular signal-regulated kinase 1/2 pathway
    Yan Ping He
    Department of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi an 710038, China
    Sheng Li Xue Bao 60:333-40. 2008
    Arginine vasopressin (AVP), a neurohormone and hemodynamic factor implicated in the pathophysiology of hypertension and congestive heart failure, can also act as a growth-stimulating factor...
  84. doi Specific expression of optically active reporter gene in arginine vasopressin-secreting neurosecretory cells in the hypothalamic-neurohypophyseal system
    Y Ueta
    Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Neuroendocrinol 20:660-4. 2008
    The anti-diuretic hormone arginine vasopressin (AVP) is synthesised in the magnocellular neurosecretory cells (MNCs) in the paraventricular nucleus (PVN) and the supraoptic nucleus (SON) of the hypothalamus...
  85. doi Arginine vasopressin, fluid balance and exercise: is exercise-associated hyponatraemia a disorder of arginine vasopressin secretion?
    Tamara Hew-Butler
    Exercise Science Program, School of Health Sciences, Oakland University, Rochester, Michigan 48309, USA
    Sports Med 40:459-79. 2010
    ..endocrine regulator of whole body fluid homeostasis is the posterior pituitary hormone, arginine vasopressin (AVP)...
  86. ncbi Effects of centrally administered vasopressin on orofacial pain perception in rats
    Maria Zubrzycka
    Department of Experimental and Clinical Physiology, Institute of Physiology and Biochemistry, Medical University of Lodz, 92 215 Lodz, Mazowiecka 6 8, Poland
    Brain Res 1051:112-6. 2005
    Vasopressin (AVP) appears in the cerebrospinal fluid and plays an important role in nociceptive modulation in the central nervous system...
  87. ncbi Partial nephrogenic diabetes insipidus caused by a novel mutation in the AVPR2 gene
    Mia Faerch
    Department of Pediatrics, Aarhus University Hospital, Skejby, Aarhus, Denmark
    Clin Endocrinol (Oxf) 68:395-403. 2008
    To identify the molecular basis and clinical characteristics of X-linked congenital nephrogenic diabetes insipidus (CNDI) presenting with an unusual phenotype characterized by partial resistance to AVP.
  88. ncbi Pharmacological characterization of arginine vasotocin vascular smooth muscle receptors in the trout (Oncorhynchus mykiss) in vitro
    D J Conklin
    South Bend Center for Medical Education, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Gen Comp Endocrinol 114:36-46. 1999
    ..Other neurohypophysial peptides, including arginine vasopressin (AVP), lysine vasopressin (LVP), isotocin (IST), and oxytocin (OXY), contracted EBA with an efficacy order of (most to ..
  89. ncbi Molecular cloning and structural analysis of quinohemoprotein alcohol dehydrogenase ADH-IIG from Pseudomonas putida HK5
    Hirohide Toyama
    Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    J Mol Biol 352:91-104. 2005
    ..used as growth substrates, Pseudomonas putida HK5 produces two distinct quinohemoprotein alcohol dehydrogenases, ADH-IIB and ADH-IIG, both of which contain pyrroloquinoline quinone (PQQ) and heme c as the prosthetic groups but show ..
  90. ncbi Chlorpropamide upregulates antidiuretic hormone receptors and unmasks constitutive receptor signaling
    J A Durr
    Division of Nephrology, Department of Veterans Affairs Medical Center, Bay Pines, Florida 33744, USA
    Am J Physiol Renal Physiol 278:F799-808. 2000
    ..CP competitively inhibited antidiuretic hormone (ADH) binding and adenylyl cyclase (AC) stimulation (inhibition constants K(i) and K'(i) of 2...
  91. ncbi Intracerebroventricular administration of atrial natriuretic peptide prevents increase of plasma ADH, aldosterone and corticosterone levels in restrained conscious dehydrated rabbits
    C Kallaras
    Department of Experimental Physiology, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Endocrinol Invest 27:844-53. 2004
    In order to investigate the effects of centrally administered ANP on plasma ADH, aldosterone and corticosterone levels as well as on blood pressure and on heart rate, 20 male New Zealand White (NZW) rabbits were used...
  92. ncbi Genetic AVP deficiency abolishes cold-induced diuresis but does not attenuate cold-induced hypertension
    Zhongjie Sun
    Dept of Medicine, Box 100274, College of Medicine, Univ of Florida, 1600 SW Archer Rd, Gainesville, FL 32610 0274, USA
    Am J Physiol Renal Physiol 290:F1472-7. 2006
    Chronic cold exposure causes hypertension and diuresis. The aim of this study was to determine whether vasopressin (AVP) plays a role in cold-induced hypertension and diuresis...
  93. ncbi Negligible role of catecholaminergic receptors in the anteroventral third ventricular region in mediating vasopressin-releasing and cardiovascular actions of prostaglandin E2
    K Yamaguchi
    Department of Physiology, Niigata University School of Medicine, Japan
    Exp Brain Res 129:532-40. 1999
    ..region (AV3V), a cerebral site engaged in various stress responses, in prostaglandin (PG) E2-evoked vasopressin (AVP) release and cardiovascular action...
  94. ncbi Responses induced by arginine-vasopressin injection in the plasma concentrations of adrenocorticotropic hormone, cortisol, growth hormone and metabolites around weaning time in goats
    K Katoh
    Department of Animal Physiology, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori, Aoba ku, Sendai 981 8555, Japan
    J Endocrinol 187:249-56. 2005
    ..hormone (ACTH), cortisol, growth hormone (GH) and metabolites in response to stimulation with arginine-vasopressin (AVP) and corticotropin-releasing hormone (CRH), we carried out three experiments in which male goats before and after ..
  95. ncbi [Alcohol dehydrogenase and aldehyde dehydrogenase as tumour markers and factors intensifying carcinogenesis in colorectal cancer]
    Wojciech Jelski
    Uniwersytet Medyczny w Białymstoku, Zakład Diagnostyki Biochemicznej
    Pol Merkur Lekarski 24:506-10. 2008
    Numerous experiments have shown that alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are present in cells of various cancers and play role in carcinogenesis...
  96. ncbi Urinary ET-1, AVP and sodium in premature infants treated with indomethacin and ibuprofen for patent ductus arteriosus
    Vincenzo Zanardo
    Department of Pediatrics, Padua University School of Medicine, Via Giustiniani 3, 35128 Padua, Italy
    Pediatr Nephrol 20:1552-6. 2005
    ..Excretion rates of AVP, ET-1 and sodium were measured in premature infants with RDS receiving indomethacin or ibuprofen...
  97. ncbi Effect of an increase in brain serotonin on the osmoregulatory response to a hypo- or hyperosmotic load in Wistar and vasopressin-deficient Brattleboro rats
    L Ivanova
    Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
    Neuroendocrinology 85:242-8. 2007
    Serotonin and its receptor agonists stimulate the release of arginine vasopressin (AVP) into peripheral blood under intraventricular injection...
  98. ncbi Increased colocalization of corticotropin-releasing factor and arginine vasopressin in paraventricular neurones of the hypothalamus in lactating rats: evidence from immunotargeted lesions and immunohistochemistry
    C D Walker
    Douglas Hospital Research Center, Department of Psychiatry, McGill University, Montreal, Canada
    J Neuroendocrinol 13:74-85. 2001
    ..expression of hypothalamic corticotropin-releasing factor (CRF) mRNA and modest increases in arginine vasopressin (AVP) expression in the paraventricular nucleus (PVN)...
  99. ncbi Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes
    N Y Kedishvili
    Dept of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202 5122
    J Biol Chem 270:3625-30. 1995
    A full-length 1966-base pair clone of the human class IV alcohol dehydrogenase (sigma-ADH) was isolated from a human stomach cDNA library. The 373-amino acid sigma-ADH encoded by this cDNA was expressed in Escherichia coli...
  100. pmc The dual AngII/AVP receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model
    Nelson Ruiz-Opazo
    Whitaker Cardiovascular Clinic, Boston, MA 02118, USA
    Mol Med 8:24-32. 2002
    ..The functional properties and renal-specific expression of the recently characterized AngII/AVP receptor suggest a putative modulator role in tubular sodium and fluid reabsorption...
  101. ncbi [The use of arginine vasopressin during cardiopulmonary resuscitation. An analysis of experimental and clinical experience and a view of the future]
    V Wenzel
    Leopold Franzens Universitat, Univ Klinik für Anaesthesie und Allg Intensivmedizin, Anichstrasse 35, 6020 Innsbruck, Osterreich
    Anaesthesist 51:191-202. 2002
    ..During CPR in patients, endogenous arginine vasopressin (AVP) levels were increased and surviving vs. non-surviving patients had significantly higher AVP levels...

Research Grants76

  1. Neurodevelopmental Mechanisms of Social Behavior
    PAT R LEVITT; Fiscal Year: 2011
    ..In Aims 1 and 2, experiments will investigate the interactions of the oxytocin (OXT) and arginine-vasopressin (AVP) neuropeptide systems with ?-aminobutyric acid-synthesizing (GABA) interneurons, which are powerful modulators of ..
  2. JOSEPH D WALCH; Fiscal Year: 2014
    ..Increased circulating levels of the antidiuretic hormone, vasopressin, contribute to the development of both ascites and hyponatremia...
  3. Neural Control of Vasopressin Release
    J Thomas Cunningham; Fiscal Year: 2013
    ..will be among the first to test the role of the BDNF-TrkB signaling in the homeostatic regulation of the neurohypophyseal system and in an animal model of inappropriate vasopressin release...
  4. DEPOLARIZATION-SECRETION COUPLING IN NERVE TERMINALS
    Jose R Lemos; Fiscal Year: 2012
    ..Vasopressin (AVP) and oxytocin (OT) are synthesized by magnocellular neurons of the hypothalamus and secreted from neurohypophysial (..
  5. Mohammad Al-Bataineh; Fiscal Year: 2015
    ..The hormone arginine vasopressin (AVP;or antidiuretic hormone) is secreted from the hypothalamus/pituitary as a normal response to increased serum osmolality or ..
  6. Vicente E Torres; Fiscal Year: 2016
    ..These studies have led to currently active clinical trials of arginine vasopressin (AVP) V2 receptor antagonists and long-acting somatostatin analogs...
  7. A Potential New Drug for Depression
    EVE DAMIANO; Fiscal Year: 2009
    ..Arginine Vasopressin (AVP) antagonists represent a novel therapeutic class for the treatment of depression...
  8. Neuropeptide regulation of neurohypophyseal function
    Francis W Flynn; Fiscal Year: 2012
    ..The nuclear translocation of the neurokinin receptor to the nucleus is novel and has implications for a large number of pathologies, such as epilepsy, that are linked to this receptor system in the brain. ..
  9. Dennis Brown; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Our finding that AQP2 constitutively recycles in the absence of the antidiuretic hormone, vasopressin (VP), has led to a rethinking of how VP causes AQP2 membrane accumulation and urinary concentration...
  10. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ..Other PVN neuropeptides, such as vasopressin (AVP) and oxytocin (OT), modulate activity of CRH neurons at the level of the PVN as well as enhancing CRH secretogogue ..
  11. KININ REGULATION OF COLLECTING DUCT H+ EFFLUX
    YURII MUKHIN; Fiscal Year: 2002
    ..For example, arginine vasopressin (AVP, antidiuretic hormone) V2 receptors are expressed on the basolateral face of cells ranging from the cortical collecting duct to ..
  12. Michael Q Steinman; Fiscal Year: 2014
    ..Oxytocin (OT) and arginine vasopressin (AVP) are related neuroproteins that play important roles in social interactions...
  13. Karen J Parker; Fiscal Year: 2014
    ..A large body of research has shown that the closely related neuropeptides arginine-vasopressin (AVP) and oxytocin (OT) play critical roles in adaptive social functioning...
  14. Autism: neuropeptide hormones and potential pathway genes
    Suma Jacob; Fiscal Year: 2012
    ..Using an existing sample of patients, the investigator will examine whether genes in the OT and vasopressin (AVP) systems are associated with autism overall, and with specific phenotypic subgroups...
  15. Does diminished oxytocin modulate stress vulnerability in Schizophrenia
    MORRIS BENJAMIN GOLDMAN; Fiscal Year: 2010
    ..with water imbalance have enhanced activity of the hypothalamic-pituitary-adrenal (HPA) axis and the antidiuretic hormone (arginine vasopressin: AVP) in response to psychological stress...
  16. Central Vasopressin and Maternal Behavior
    Benjamin C Nephew; Fiscal Year: 2010
    ..Recent molecular studies indicate that the neurohormones arginine vasopressin (AVP), oxytocin (OXT), and corticosteroid releasing hormone (CRH) may be involved in the modulation of maternal behavior ..
  17. Neurobiological Mechanisms of Social Bonding in a Monogamous Primate
    Karen L Bales; Fiscal Year: 2013
    ..Arginine vasopressin (AVP) and oxytocin (OT) are neuropeptide hormones known to be involved in social bonding in rodents...
  18. Benjamin C Nephew; Fiscal Year: 2014
    ..Recent molecular studies indicate that the neurohormones arginine vasopressin (AVP), oxytocin (OXT), and corticosteroid releasing hormone (CRH) may be involved in the modulation of maternal behavior ..
  19. Regulation and Function of Internal Ca2+ Stores in Nerve Terminals
    John V Walsh; Fiscal Year: 2010
    The purpose of this proposal is to examine the role of internal Ca2 + stores in neurohypophyseal nerve terminals of magnocellular hypothalamic neurons found in the posterior pituitary...
  20. Interactive effects of ethanol and estrogen on brain vasopressin during puberty
    Toni R Pak; Fiscal Year: 2010
    ..Our overall objective is to identify the interactive effects of alcohol and estrogen on arginine vasopressin (AVP), a well-established key molecular mediator of anxiety, in order to elucidate the molecular mechanisms predisposing ..
  21. Mechanism(s) of Alcoholic Pancreatitis
    Bhupendra S Kaphalia; Fiscal Year: 2011
    ..nonoxidative lipid metabolites of ethanol) and endoplasmic reticulum (ER) stress in hepatic alcohol dehydrogenase (ADH)-deficient (ADH-) vs. normal ADH (ADH+) deer mice fed 3...
  22. Andrey E Ryabinin; Fiscal Year: 2015
    ..as do humans and that this influence is regulated by dominant/submissive relations, the opiate and the vasopressin (AVP) systems. We propose to test this hypothesis through following four Specific Aims...
  23. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2011
    ..the mechanisms of the effects of cytokines and hormones on the regulation of rat class I alcohol dehydrogenase (ADH)...
  24. Eliciting protective mechanisms against alcoholism
    Emanuel Rubin; Fiscal Year: 2010
    ..Studies in this application test the hypothesis that a reduction ofALDH2 gene expression or ADH gene transduction decrease voluntary ethanol intake in rats, thus mimicking the natural protective mechanisms...
  25. Alcohol and Muscle Stem Cells
    Gordon Huggins; Fiscal Year: 2009
    ..As shown in our preliminary data, alcohol alone and in conjunction with the metabolic enzyme alcohol dehydrogenase (ADH), significantly reduces the transcriptional activity of the cardiac determination transcription factor GATA4...
  26. KCNQ Channels and Vasoconstrictor Signal Transduction
    Kenneth L Byron; Fiscal Year: 2013
    ..of arterial myocyte excitability by physiological vasoconstrictor concentrations of arginine vasopressin (AVP, 10-100 pM) involves protein-kinase C-dependent suppression of KCNQ5 channel activity...
  27. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..hormone (CRH), BDNF, GABA, GLU, neuronal NO (nNOS), estrogen receptors (ER)a and p, and arginine vasopressin (AVP))...
  28. Screening New Therapeutics for the Treatment of Post Traumatic Stress Disorder
    NEAL GORDON SIMON; Fiscal Year: 2011
    ..Arginine Vasopressin (AVP) 1a receptor antagonists represent a potential new approach for the treatment of PTSD;both clinical and preclinical ..
  29. Richard H Melloni; Fiscal Year: 2015
    ..a high level of offensive aggression that is modulated by the anterior hypothalamic (AH) arginine vasopressin (AVP) and serotonin (5HT) neural systems...
  30. Reena Rao; Fiscal Year: 2015
    ..2) The mechanism by which AVP signaling activates GSK3 will be determined by testing the hypothesis that AVP signaling activates GSK3 by ..
  31. Vasopressin in the regulation of serotonin and anxiety
    BENJAMIN DAVID ROOD; Fiscal Year: 2013
    ..a number of pharmacological and gene-manipulation studies in rodents have implicated the neuropeptide vasopressin (AVP) in social behaviors including social memory, parental behavior, mating behavior, and pair-bonding...
  32. Characterization of AQP2 interacting proteins and novel functions of AQP2
    HUA A LU; Fiscal Year: 2010
    ..Vasopressin (VP) is the major antidiuretic hormone involved in the regulation of water reabsorption by mammalian kidney...
  33. Perenlei Enkhbaatar; Fiscal Year: 2016
    ..promoting Ang-2 release;3) a selective V1aR agonist is superior to a mixed V1aR/V2R agonist arginine vasopressin (AVP) for preventing cardiovascular collapse...
  34. Ligand-independent signaling of estrogen receptor beta and the aging brain
    Toni R Pak; Fiscal Year: 2013
    ..altered as a direct result of the aging process: gonadotropin-releasing hormone (GnRH) and arginine vasopressin (AVP)...
  35. Charles E Wood; Fiscal Year: 2016
    ..three specific aims in the renewal of this project: 1) to test the hypothesis that ACTH and Arginine Vasopressin (AVP), but not autonomic nervous system responses to BCO, isocapnic hypoxic hypoxia (HH), and partial umbilical cord ..
  36. CARRIE ADELIA SIMS; Fiscal Year: 2015
    ..Recently, the hormone arginine vasopressin (AVP) has been investigated as an adjunct during the resuscitation of severe trauma...
  37. PAVEN AUJLA; Fiscal Year: 2015
    ..with an ectopic posterior pituitary (EPP), which contains the terminal axons of hypothalamic arginine vasopressin (AVP) neurons. In fact, human mutations of HESX1, LHX4 and SOX3 result in EPP as well as hypopituitarism...
  38. MARTHA E O'DONNELL; Fiscal Year: 2016
    ..in the luminal BBB membrane, are stimulated by ischemic factors, including hypoxia, aglycemia and vasopressin (AVP) and that inhibiting BBB NKCC and/or NHE activity reduces brain edema in the rat middle cerebral artery occlusion (..
  39. Estrogen receptor beta protein:protein interactions following estrogen withdrawal
    NATASHA MOTT; Fiscal Year: 2013
    ..in the absence of estrogens, ER? activates transcription of target genes, including arginine vasopressin (AVP), a critical regulator of anxiety...
  40. X-linked recessive familial neuro-hypophyseal diabetes insipidus
    PETER ANDREAS KOPP; Fiscal Year: 2010
    ..form is caused by mutations in the AVP-NPII gene located on chromosome 20p13, which encodes the antidiuretic hormone vasopressin (AVP), and is usually inherited in an autosomal dominant fashion...
  41. Mechanisms and Meanings of Impaired Microvascular Responses in Human Sepsis
    Kevin C Doerschug; Fiscal Year: 2013
    ..The renin- angiotensin system (RAS) and arginine vasopressin (AVP) system represent two response systems that undergo changes with microvascular implications in human sepsis...
  42. BLOOD-BRAIN BARRIER ION TRANSPORT IN CEREBRAL ISCHEMIA
    MARTHA E O'DONNELL; Fiscal Year: 2012
    ..in the luminal BBB membrane, are stimulated by ischemic factors, including hypoxia, aglycemia and vasopressin (AVP) and that inhibiting BBB NKCC and/or NHE activity reduces brain edema in the rat middle cerebral artery occlusion (..
  43. Socially-facilitated excessive alcohol drinking in a novel prairie vole model
    ALLISON MJ ANACKER; Fiscal Year: 2012
    ..Brains from the same animals will be used to determine V1aR binding level by autoradiography, using a 125I- linear-AVP antagonist as a ligand for the V1aR...
  44. Bellamkonda K Kishore; Fiscal Year: 2016
    ..i) purinergic signaling may play a potential overarching role in balancing the effect of arginine vasopressin (AVP) on the urinary concentration mechanism;(ii) in lithium-induced NDI, purinergic signaling in the medullary ..
  45. Phosphodiesterases in Lithium-Induced Nephrogenic Diabetes Insipidus
    Mitsi A Blount; Fiscal Year: 2012
    ..insipidus (NDI) is characterized by the inability of the kidney to concentrate urine in the presence of the antidiuretic hormone, vasopressin, thereby leading to excessive volumes of dilute urine...
  46. Richmond R Thompson; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Arginine vasopressin (AVP) and related peptides have profound influences on social behaviors in vertebrates, particularly on emotional aggressive and affiliative interactions between individuals...
  47. New Drugs for Stress-related Affective Illness
    Michael Brownstein; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vasopressin (AVP) antagonists represent a novel therapeutic class for the treatment of depression...
  48. Thomas A Kocarek; Fiscal Year: 2014
    ..to farnesol accumulation and CAR activation, and these changes are enhanced by inhibition of alcohol dehydrogenase (ADH)-catalyzed farnesol metabolism. Other changes (e.g...
  49. GABA-ERGIC MECHANISMS INFLUENCING VASOPRESSIN RELEASE
    JOSEPH HAYWOOD; Fiscal Year: 1990
    ..term goal of this program is to understand the relationship between physiological stimuli for arginine vasopressin (AVP) release and the interactions of neurotransmitters which regulate vasopressin secretion...
  50. CONTROLS FOR ASSOCIATION STUDIES OF ALCOHOLISM
    Kenneth Kidd; Fiscal Year: 2009
    ..The alcohol dehydrogenase (ADH) cluster of genes and the aldehydedehydrogenase 2 locus...
  51. A Breath-based Naltrexone Adherence Tool to Manage Narcotic-addicted HIV patients
    DONN MICHAEL DENNIS; Fiscal Year: 2012
    ..g., 2-butanol) are superior taggants metabolized by alcohol dehydrogenase (ADH is not subject to genetic polymorphisms, unlike the isoform) to generate volatile ketones (e.g...
  52. Fatty Acid Ethyl Esters in Ethanol-induced Pancreatitis
    Bhupendra Kaphalia; Fiscal Year: 2006
    ..Oxidative metabolism of ethanol catalyzed by alcohol dehydrogenase (ADH) is negligible in the pancreas, while nonoxidative metabolism of ethanol to fatty acid ethyl esters (FAEEs), ..
  53. GENETIC AND DIETARY CONTROL OF ALCOHOL METABOLISM
    BILLY GEER; Fiscal Year: 1992
    ..Since more than 90% of the dietary ethanol is degraded by the alcohol dehydrogenase (ADH) pathway in D. melanogaster it is important to learn how the pathway is regulated and what its components are...
  54. REGULATION OF ALCOHOL DEHYDROGENASE GENE EXPRESSION
    Gregg Duester; Fiscal Year: 2000
    Vertebrate alcohol dehydrogenase (ADH) is encoded by a family of genes falling into seven classes with unique patterns of tissue-specific and developmental expression...
  55. ALCOHOL METABOLISM GENES IN TRANSGENIC MICE
    Michael Felder; Fiscal Year: 2007
    ..At least three enzyme activities in liver are capable of converting ethanol to acetaldehyde, alcohol dehydrogenase (ADH), cytochrome P450 2E1 (CYP2E1), and catalase Although CYP2E1 is inducible by chronic alcohol exposure, results ..
  56. HUMAN ALCOHOL AND ALDEHYDE DEHYDROGENASES
    Ting Kai Li; Fiscal Year: 1990
    ..Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are the principal enzymes responsible for ethanol metabolism in the liver...
  57. HUMAN ALCOHOL & ALDEHYDE DEHYDROGENASES
    Ting Kai Li; Fiscal Year: 1999
    ..Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are the principal enzymes responsible for ethanol metabolism in the liver...
  58. TRANSCRIPTIONAL REGULATION OF ALCOHOL DEHYDROGENASE GENE
    VINCENT YANG; Fiscal Year: 1993
    Alcohol dehydrogenase (ADH) is the principal enzyme responsible for ethanol metabolism. THe gene encoding the class I ADH is primarily expressed in the liver of vertebrates...
  59. FACTORS CONTROLLING ALCOHOL DEHYDROGENASE TRANSCRIPTION
    Gregg Duester; Fiscal Year: 1991
    This is a request for an ADAMHA RSDA (Level II). Alcohol dehydrogenase (ADH) is the rate-limiting step in the oxidation of alcohol by mammals...
  60. A SYSTEM FOR ANALYSIS OF GENE CONTROL IN DROSOPHILA
    WILLIAM SOFER; Fiscal Year: 1991
    ..proximal cis-acting control elements that regulate tissue-specific gene expression of the alcohol dehydrogenase (ADH) gene in Drosophila melanogaster...
  61. STRUCTURE & EXPRESSION OF MAMMAL ALC DEHYDROGENASE GENES
    Howard Edenberg; Fiscal Year: 2000
    ..long term Goals of this research are to understand the mechanisms which regulate mammalian alcohol dehydrogenase (ADH) gene expression, and the physiological and pathological consequences of alterations in ADH expression...
  62. GENETICS OF ALCOHOL SENSITIVITY
    Shozo Yokoyama; Fiscal Year: 1992
    In the human liver, ethanol is degraded by dimeric alcohol dehydrogenase (ADH) to acetaldehyde (AcH) and then by tetrameric aldehyde dehydrogenase (ALDH) with the subsequent production of acetate, and finally Co 2 and H20...
  63. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..suggests that they share a similar vocal pathway forebrain organization: a premotor or anterior vocal pathway (AVP) necessary for vocal learning, including syntax learning, and a motor or posterior vocal pathway (PVP) necessary ..
  64. SIGNALING BY VASOPRESSIN--ARTERIAL SMOOTH MUSCLE CELLS
    KENNETH BYRON; Fiscal Year: 2002
    Arginine8]-vasopressin (AVP) is a peptide hormone which is released from the posterior pituitary gland in response to a decrease in blood pressure or an increase in plasma osmolality...
  65. ANTIDIURESIS REGULATES NA+/H EXCHANGERS
    ADAM SUN; Fiscal Year: 1999
    ..For acute antidiuresis, I will study the acute effects of AVP, hyperosmolality and their interactions on the apical and basolateral NHE in in vitro perfused mouse MTAL tubules...
  66. CENTRAL VASOPRESSIN AND SOCIAL ATTACHMENT
    Zuoxin Wang; Fiscal Year: 2000
    ..Several lines of evidence implicate central vasopressin (AVP) pathways in the process by which mating facilitates prairie vole social attachment...
  67. Etiology of Age-Related Defects in Urine Concentration
    Ying Tian; Fiscal Year: 2001
    ..The pituitary hormone arginine vasopressin (AVP) is the major regulator of renal water excretion...
  68. Vasopressin Receptors, Social Behaviors, & Anxiety
    ISADORA BIELSKY; Fiscal Year: 2004
    Vasopressin (AVP) is a peptide produced in the brain and released both centrally and peripherally. The central actions of AVP include effects on both social and non-social behaviors...
  69. P2U(P2Y2)-PURINOCEPTOR AND WATER TRANSPORT IN RAT KIDNEY
    BELLAMKONDA KISHORE; Fiscal Year: 2004
    ..While arginine vasopressin (AVP), acting through its V2 receptor and the camp second messenger system, increases the water permeability of the ..
  70. VASOPRESSIN PHYSIOLOGY IN THE FETUS AND NEWBORN
    Delbert Fisher; Fiscal Year: 1991
    In fetal and adult mammals the neurohypophysial peptide arginine vasopressin (AVP) is secreted in response to similar osmotic and volume stimuli...
  71. INHERITED HYPOTHALAMIC NEURODEGENERATION
    David Repaske; Fiscal Year: 2001
    Autosomal dominant neurohypophyseal diabetes insipidus (ADNDI) is an inherited endocrine disorder caused by a progressive and specific degeneration of the magnocellular neurons that produce the hormone, vasopressin...
  72. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2003
    ..Osmotically stimulated arginine vasopressin (AVP) increases during estrogen administration and during the phases of the menstrual cycle when estrogen and ..
  73. MATERNAL DEHYDRATION--FETAL/AMNIOTIC FLUID HOMEOSTASIS
    Michael Ross; Fiscal Year: 2002
    ..have developed a novel model to increase AF volume utilizing maternal administration of the arginine vasopressin (AVP) antidiuretic agonist [desamino, D-Arg8]-AVP (DDAVP)...
  74. MOLECULAR DISSECTION OF CONGENITAL NEPHROGENIC DI
    ROBERT WILDIN; Fiscal Year: 2000
    ..intake because the kidney is insensitive to the effects of the water-sparing, pituitary-derived hormone, antidiuretic hormone (ADH)...
  75. ARGININE VASOTOCIN IN THE OVINE FETUS AND NEWBORN
    M Ervin; Fiscal Year: 1991
    The mammalian neurohypophysial hormones arginine vasopressin (AVP) and oxytocin (OXT) are primarily synthesized in the hypothalamus as large molecular weight prohormones composed of AVP or OXT and their sequence specific carrier proteins,..
  76. VASOTOCIN RECEPTORS
    PATRICK EGGENA; Fiscal Year: 1990
    The antidiuretic hormone, vasopressin (AVP), plays an important role in the regulation of plasma volume and osmolality by triggering the reabsorption of water, urea, and sodium from the forming uring in the kidney...