ATF6

Summary

Gene Symbol: ATF6
Description: activating transcription factor 6
Alias: ACHM7, ATF6A, cyclic AMP-dependent transcription factor ATF-6 alpha, cAMP-dependent transcription factor ATF-6 alpha
Species: human

Top Publications

  1. ncbi Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells
    Emma L Davenport
    Section of Haemato oncology, Cancer Research UK, The Institute of Cancer Research, Sutton, Surrey, UK
    Blood 110:2641-9. 2007
  2. ncbi Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation
    Yoshinori Tsukumo
    Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo 135 8550, Japan
    J Biol Chem 282:29264-72. 2007
  3. pmc Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart
    Peter J Belmont
    The SDSU Heart Institute and The Department of Biology, San Diego State University, San Diego, CA 92182, USA
    Circ Res 106:307-16. 2010
  4. pmc PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes
    Koji Isodono
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    PLoS ONE 5:e9746. 2010
  5. ncbi Curcumin inhibits the proliferation of human hepatocellular carcinoma J5 cells by inducing endoplasmic reticulum stress and mitochondrial dysfunction
    Chun Yuan Cheng
    Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan, ROC
    Int J Mol Med 26:673-8. 2010
  6. doi Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6
    Min Guan
    Department of Molecular Pharmacology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Clin Cancer Res 17:1796-806. 2011
  7. pmc Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response
    K Haze
    HSP Research Institute, Kyoto Research Park, 17 Chudoji minami, Shimogyo ku, Kyoto 600 8813, Japan
    Biochem J 355:19-28. 2001
  8. pmc Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1
    Nobuhiro Morishima
    Molecular Membrane Biology Laboratory, RIKEN Advanced Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biol Chem 286:35227-35. 2011
  9. pmc Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-i
    Shengzhan Luo
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles 90089 9176, USA
    Biochem J 366:787-95. 2002
  10. pmc Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways
    Can E Senkal
    Hollings Cancer Center, 86 Jonathan Lucas Street, Charleston, SC 29425, USA
    FASEB J 24:296-308. 2010

Research Grants

  1. Structure and Function of Proteins in Unfolded Protein Response
    Zhaohui Xu; Fiscal Year: 2005
  2. Fatty acid synthase inhibitors and prostate cancer
    Steven J Kridel; Fiscal Year: 2010
  3. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
  4. CFTR Biogenesis and Function in Epithelia
    Zsuzsa Bebok; Fiscal Year: 2012
  5. DHAN V KALVAKOLANU; Fiscal Year: 2014
  6. Matthew M Lavail; Fiscal Year: 2014
  7. Mechanisms of ER stress - induced fatty liver
    D Thomas Rutkowski; Fiscal Year: 2013
  8. Scott R Whittemore; Fiscal Year: 2015
  9. Avoiding toxicity associated with MTP ablation
    M Mahmood Hussain; Fiscal Year: 2013
  10. Restoration of Endoplasmic Reticulum Function in Experimental Stroke
    Wulf Paschen; Fiscal Year: 2013

Detail Information

Publications276 found, 100 shown here

  1. ncbi Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells
    Emma L Davenport
    Section of Haemato oncology, Cancer Research UK, The Institute of Cancer Research, Sutton, Surrey, UK
    Blood 110:2641-9. 2007
    ..upregulation of CHOP consistent with ER resident kinase (PERK) activation, and activating transcription factor 6 (ATF6) splicing...
  2. ncbi Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation
    Yoshinori Tsukumo
    Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo 135 8550, Japan
    J Biol Chem 282:29264-72. 2007
    In response to endoplasmic reticulum (ER) stress, activating transcription factor 6 (ATF6), an ER membrane-anchored transcription factor, is transported to the Golgi apparatus and cleaved by site-1 protease (S1P) to activate the unfolded ..
  3. pmc Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart
    Peter J Belmont
    The SDSU Heart Institute and The Department of Biology, San Diego State University, San Diego, CA 92182, USA
    Circ Res 106:307-16. 2010
    ..ERAD is increased by the ER stress modulator, activating transcription factor (ATF)6, which can induce genes that encode components of the ERAD machinery...
  4. pmc PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes
    Koji Isodono
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    PLoS ONE 5:e9746. 2010
    ..PARM-1 silencing also repressed expression of PERK and ATF6, and augmented expression of CHOP without affecting IRE-1 expression and JNK and Caspase-12 activation...
  5. ncbi Curcumin inhibits the proliferation of human hepatocellular carcinoma J5 cells by inducing endoplasmic reticulum stress and mitochondrial dysfunction
    Chun Yuan Cheng
    Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan, ROC
    Int J Mol Med 26:673-8. 2010
    ..The cell viability was detected by MTT assay. The protein expressions of caspase-12, ATF6, GADD153, Calnexin, Calreticulin, PDI and Ero1-Lα, which are associated with endoplasmic reticulum stress and the ..
  6. doi Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6
    Min Guan
    Department of Molecular Pharmacology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Clin Cancer Res 17:1796-806. 2011
    ..We postulate that NFV interferes with regulated intramembrane proteolysis of SREBP-1 and ATF6 (activating transcription factor 6).
  7. pmc Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response
    K Haze
    HSP Research Institute, Kyoto Research Park, 17 Chudoji minami, Shimogyo ku, Kyoto 600 8813, Japan
    Biochem J 355:19-28. 2001
    ..We recently identified the basic leucine zipper (bZIP) protein ATF6 as a mammalian UPR-specific transcription factor; ATF6 is activated by ER stress-induced proteolysis and binds ..
  8. pmc Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1
    Nobuhiro Morishima
    Molecular Membrane Biology Laboratory, RIKEN Advanced Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biol Chem 286:35227-35. 2011
    ..Among the three proximal sensors of ER stress, activating transcription factor-6 (ATF6) is specifically activated in apoptotic myoblasts during myoblast differentiation...
  9. pmc Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-i
    Shengzhan Luo
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles 90089 9176, USA
    Biochem J 366:787-95. 2002
    ..We identified an ER transmembrane activating transcription factor 6 (ATF6) as a target of p38 MAPK phosphorylation in AzC-treated cells...
  10. pmc Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways
    Can E Senkal
    Hollings Cancer Center, 86 Jonathan Lucas Street, Charleston, SC 29425, USA
    FASEB J 24:296-308. 2010
    ..regulation of ER-stress-induced apoptosis by CerS6/C(16)-ceramide was linked to the activation of a specific arm, ATF6/CHOP, of the unfolded protein response pathway...
  11. ncbi Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers
    T W Hai
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
    Genes Dev 3:2083-90. 1989
    ..Our results help to explain how a single promoter element, an ATF site, can be present in a wide variety of promoters...
  12. pmc Interaction of ATF6 and serum response factor
    C Zhu
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Mol Cell Biol 17:4957-66. 1997
    ..b>ATF6, a basic-leucine zipper protein, was isolated by binding to SRF and in particular to its transcriptional activation ..
  13. ncbi Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors
    H Yoshida
    HSP Research Institute, Kyoto Research Park, Kyoto 600 8813, Japan
    J Biol Chem 273:33741-9. 1998
    ..Using yeast one-hybrid screening, we isolated a human cDNA encoding a basic leucine zipper (bZIP) protein, ATF6, as a putative ERSE-binding protein...
  14. pmc Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
    K Haze
    HSP Research Institute, Kyoto Research Park, Shimogyo ku, Kyoto 600 8813, Japan
    Mol Biol Cell 10:3787-99. 1999
    ..We recently isolated ATF6 as a candidate for mammalian UPR-specific transcription factor...
  15. ncbi XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
    H Yoshida
    Graduate School of Biostudies, Kyoto University, Kyoto 606 8304, Japan
    Cell 107:881-91. 2001
    ..Instead, the transcription factor ATF6 specific to the mammalian UPR is regulated by intramembrane proteolysis...
  16. ncbi Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP
    Tomomi Gotoh
    Department of Molecular Genetics, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    J Biol Chem 277:12343-50. 2002
    ..In addition, apoptosis induced by p50ATF6 was prevented by a CHOP dominant negative form as well as by an ATF6 dominant negative form, and LPS/IFN-gamma-induced apoptosis was prevented by the CHOP dominant negative form...
  17. ncbi Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians
    Farook Thameem
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445 N 5th St, Suite 210, Phoenix, AZ 85004, USA
    Diabetes 55:839-42. 2006
    Activating transcription factor 6 (ATF6) is important for protective cell response to accumulation of unfolded and misfolded proteins in endoplasmic reticulum, and disturbances of this process can contribute to beta-cell apoptosis...
  18. pmc Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits
    Winston S Chu
    Division of Endocrinology 111J 1 LR, Department of Medicine, University of Arkansas for Medical Sciences, John L McClellan Memorial Veterans Hospital, 4700 W 7th Street, Little Rock, AR 72205, USA
    Diabetes 56:856-62. 2007
    Activating transcription factor 6 (ATF6) is located within the region of linkage to type 2 diabetes on chromosome 1q21-q23 and is a key activator of the endoplasmic reticulum stress response...
  19. pmc Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells
    Sonya G Fonseca
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    J Clin Invest 120:744-55. 2010
    ..These results reveal a role for WFS1 in the negative regulation of ER stress signaling and in the pathogenesis of diseases involving chronic, unresolvable ER stress, such as pancreatic beta cell death in diabetes...
  20. pmc Lack of association between genetic polymorphisms within DUSP12 - ATF6 locus and glucose metabolism related traits in a Chinese population
    Cheng Hu
    Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, PR China
    BMC Med Genet 12:3. 2011
    ..Studies in Pima Indian, Caucasians and African Americans identified several SNPs in DUSP12 and ATF6, located in chromosome 1q21-q23, were associated with type 2 diabetes.
  21. pmc Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response
    Tetsuya Okada
    Graduate School of Biostudies, Kyoto University, 46 29 Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8304, Japan
    Biochem J 366:585-94. 2002
    ..Thus we propose that mammalian cells have evolved a strategy to cope with ER stress different from that of yeast cells...
  22. ncbi Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6
    Jingshi Shen
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 279:43046-51. 2004
    b>ATF6 is an endoplasmic reticulum (ER) membrane-anchored transcription factor activated by regulated intramembrane proteolysis in the ER stress response...
  23. ncbi Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians
    Steven J R Meex
    Cardiovascular Research Institute Maastricht, Department of Internal Medicine, University of Maastricht, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 92:2720-5. 2007
    Activating transcription factor 6 (ATF6) is critical for initiation and full activation of the unfolded protein response. An association between genetic variation in ATF6 and type 2 diabetes (DM2) was recently reported in Pima Indians.
  24. pmc Activating transcription factor 6 limits intracellular accumulation of mutant α(1)-antitrypsin Z and mitochondrial damage in hepatoma cells
    Steven E Smith
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 286:41563-77. 2011
    ..Activation of the activating transcription factor 6 (ATF6) branch of the UPR by expression of spliced ATF6(1-373) decreased intracellular accumulation of ATZ and the ..
  25. ncbi Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death
    Donald J DeGracia
    Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cereb Blood Flow Metab 22:127-41. 2002
    ..In mammals, the upstream unfolded protein response components PERK, IRE1, and ATF6 activate prosurvivial mechanisms (e.g., transcription of GRP78, PDI, SERCA2b ) and proapoptotic mechanisms (i.e...
  26. pmc Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner
    Hye Young Seo
    Department of Internal Medicine, Kyungpook National University School of Medicine, 50 Samduk 2ga, Jung Gu, Daegu 700 721, Republic of Korea
    Endocrinology 149:3832-41. 2008
    ..We examined whether ER stress decreases insulin gene expression, and this process is mediated by ATF6. A small interfering RNA that targeted SHP was used to determine whether the effect of ATF6 on insulin gene ..
  27. doi Induction of endoplasmic reticulum stress response by TZD18, a novel dual ligand for peroxisome proliferator-activated receptor alpha/gamma, in human breast cancer cells
    Chuanbing Zang
    Division of Oncology Hematology, Department of Hematology and Oncology, University Medicine Charité, Berlin, Germany
    Mol Cancer Ther 8:2296-307. 2009
    ..subunit of eukaryotic initiation factor 2 (eIF2alpha), as well as an up-regulation of GRP78 and an activation of ATF6, all of which are specific markers for endoplasmic reticulum stress...
  28. ncbi Sarco/endoplasmic reticulum calcium ATPase-2 expression is regulated by ATF6 during the endoplasmic reticulum stress response: intracellular signaling of calcium stress in a cardiac myocyte model system
    D J Thuerauf
    Heart Institute and the Department of Biology, San Diego State University, San Diego, California 92182, USA
    J Biol Chem 276:48309-17. 2001
    The recently described transcription factor, ATF6, mediates the expression of proteins that compensate for potentially stressful changes in the endoplasmic reticulum (ER), such as reduced ER calcium...
  29. ncbi Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition
    Hao Yuan Jiang
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 280:14189-202. 2005
    ..stress sensory proteins, eIF2alpha kinase PEK (PERK/EIF2AK3), IRE1 protein kinase and the transcription regulator ATF6 following up to 6 h of proteasome inhibitor treatment...
  30. ncbi Meeting Report:The 7th ESPE Growth Plate Working Group Symposium - EUROGROP June 27th 2007, Helsinki, Finland
    Razvan L Miclea
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Pediatr Endocrinol Rev 5:680-5. 2007
    ..Dehydrogenase; Agc: Aggrecan; Aln: Alendronate; Asb- 4: Ankyrin Repeat and SOCS Box-Containing Protein 4; Atf6: Activating Transcription Factor6; BSP: Bisphosphonates; Calca: Calcitonin, Alpha Cdkn2a: Cyclin-Dependent Kinase ..
  31. ncbi Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response
    Chen Chen Jiang
    Immunology and Oncology Unit, Newcastle Misericordiae Hospital, Newcastle, NSW, Australia
    Cancer Res 67:5880-8. 2007
    ..transmembrane kinase and endonuclease 1alpha (IRE1alpha) and activation of transcription factor 6 (ATF6), respectively, seemed to be involved...
  32. doi Nicotine suppresses tunicamycin-induced, but not thapsigargin-induced, expression of GRP78 during ER stress-mediated apoptosis in PC12 cells
    Harue Sasaya
    Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering and High Technology Research Center, Kansai University, 3 3 35 Yamate cho, Suita, Osaka 564 8680, Japan
    J Biochem 144:251-7. 2008
    ..that the suppression of GRP78 expression by nicotine was achieved through the suppression of the Ire1-XBP1 and/or ATF6 pathways...
  33. ncbi Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements
    Shengzhan Luo
    Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9176, USA
    J Biol Chem 278:37375-85. 2003
    ..While the activation of the Grp78 promoter by the ATF6 pathway through the endoplasmic reticulum stress elements (ERSEs) is well documented, the molecular mechanism ..
  34. ncbi In vivo regulation of Grp78/BiP transcription in the embryonic heart: role of the endoplasmic reticulum stress response element and GATA-4
    Changhui Mao
    Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9176, USA
    J Biol Chem 281:8877-87. 2006
    ..Previous studies establish that endoplasmic reticulum stress induces in vivo binding of YY1 and the nuclear form of ATF6 to the ERSE...
  35. pmc BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer
    Shinichi Kondo
    Division of Molecular and Cellular Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889 1692, Japan
    Mol Cell Biol 27:1716-29. 2007
    ..reticulum (ER) stress transducers IRE1 (inositol requiring 1), PERK (PKR-like endoplasmic reticulum kinase), and ATF6 (activating transcription factor 6) are well known to transduce signals from the ER to the cytoplasm and nucleus ..
  36. ncbi Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells
    Alessandra K Cardozo
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808 CP 618, 1070 Brussels, Belgium
    Diabetes 54:452-61. 2005
    ..and PRK (RNA-dependent protein kinase)-like ER kinase (PERK)/activating transcription factor 4 (ATF4), but not ATF6. In contrast, the ER stress-inducing agent thapsigargin triggered these four pathways in parallel...
  37. pmc Unfolded protein response and cell death after depletion of brefeldin A-inhibited guanine nucleotide-exchange protein GBF1
    Carmen Citterio
    Translational Medicine Branch and Proteomics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:2877-82. 2008
    ..Upon ER stress, transcription factor ATF6 translocates from the ER to Golgi, where it is sequentially cleaved by site 1 and site 2 proteases, S1P and S2P, to ..
  38. pmc Methamphetamine induces dopamine D1 receptor-dependent endoplasmic reticulum stress-related molecular events in the rat striatum
    Subramaniam Jayanthi
    Molecular Neuropsychiatry Research Branch, National Institute of Drug Abuse, National Institutes of Health NIH Department of Health and Human Services DHHS, Intramural Research Program, Baltimore, MD, USA
    PLoS ONE 4:e6092. 2009
    ..We also measured the expression of these genes and of ATF4, ATF6, BiP/GRP78, and of GADD34 over a more extended time course...
  39. doi The HIV protease inhibitor saquinavir induces endoplasmic reticulum stress, autophagy, and apoptosis in ovarian cancer cells
    Karen McLean
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA
    Gynecol Oncol 112:623-30. 2009
    ....
  40. doi Altered redox state of luminal pyridine nucleotides facilitates the sensitivity towards oxidative injury and leads to endoplasmic reticulum stress dependent autophagy in HepG2 cells
    Péter Száraz
    Dipartimento di Fisiopatologia, Medicina Sperimentale e Sanita Pubblica, Universita di Siena, Via Aldo Moro, 53100 Siena, Italy
    Int J Biochem Cell Biol 42:157-66. 2010
    ..Combined treatments resulted in the activation of ATF6 and procaspase-4, and in the induction of Grp78 and CHOP...
  41. doi Alterations in oxidative stress status modulate terminal differentiation in Atlantic salmon adipocytes cultivated in media rich in n-3 fatty acids
    Marijana Todorcević
    Nofima, Norwegian Institute of Food, Fisheries and Aquaculture Research, As, Norway
    Comp Biochem Physiol B Biochem Mol Biol 156:309-18. 2010
    ..reduction of OS by alpha-TOC coincided with the increased gene expression of the activating transcription factor 6 (ATF6), a transducer of the endoplasmic reticulum (ER)-stress response...
  42. pmc The flavoheme reductase Ncb5or protects cells against endoplasmic reticulum stress-induced lipotoxicity
    Yongzhao Zhang
    Department of Medicine, Hematology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Lipid Res 51:53-62. 2010
    ..The ER stress response was assessed by induction of BiP, ATF3, ATF6, XBP-1, and C/EBP homologous protein (CHOP)...
  43. pmc The SARS Coronavirus 3a protein causes endoplasmic reticulum stress and induces ligand-independent downregulation of the type 1 interferon receptor
    Rinki Minakshi
    Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    PLoS ONE 4:e8342. 2009
    ..protein response (UPR), which includes the inositol-requiring enzyme 1 (IRE-1), activating transcription factor 6 (ATF6) and PKR-like ER kinase (PERK) pathways, these were individually tested in 3a-expressing cells...
  44. doi CBF/NF-Y controls endoplasmic reticulum stress induced transcription through recruitment of both ATF6(N) and TBP
    Rong Luo
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Cell Biochem 104:1708-23. 2008
    ..reticulum (ER) stress identified a composite promoter element, ERSE that interacts with both CBF/NF-Y (CBF) and ATF6(N) transcription factors...
  45. ncbi Herp is dually regulated by both the endoplasmic reticulum stress-specific branch of the unfolded protein response and a branch that is shared with other cellular stress pathways
    Yanjun Ma
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 279:13792-9. 2004
    ..mammalian unfolded protein response (UPR) includes two major branches: one(s) specific to ER stress (Ire1/XBP-1 and ATF6-dependent), and one(s) shared by other cellular stresses (PERK/eIF-2alpha phosphorylation-dependent)...
  46. pmc Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene
    Peter J Belmont
    San Diego State University Heart Institute, San Diego State University, San Diego, California 92182, USA
    J Biol Chem 283:14012-21. 2008
    ..impair endoplasmic reticulum (ER) protein folding, leading to ER stress and activation of the transcription factor, ATF6. ATF6 binds to ER stress response elements in target genes, inducing expression of proteins that enhance the ER ..
  47. ncbi ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum
    Yusuke Adachi
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan
    Cell Struct Funct 33:75-89. 2008
    ..Mammalian cells express three UPR transducers in the ER, namely IRE1, PERK and ATF6. The IRE1 pathway, which is conserved from yeast to humans, mediates transcriptional induction of not only ER ..
  48. pmc West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis
    Guruprasad R Medigeshi
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 N W 185th Avenue, Beaverton, OR 97006, USA
    J Virol 81:10849-60. 2007
    ..1-dependent splicing of X box binding protein 1 (XBP1) mRNA, activation of activating transcription factor 6 (ATF6), and protein kinase R-like endoplasmic reticulum (ER) kinase-dependent eukaryotic initiation factor 2alpha (..
  49. pmc The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells
    Jennifer N Gass
    Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University, Chicago, United States
    Mol Immunol 45:1035-43. 2008
    ..Three specific stress sensors, IRE1, PERK/PEK and ATF6, are central to the recognition of ER stress and induction of the UPR...
  50. doi Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition
    Hai Ying Fu
    Department of Cardiovascular Medicine, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    Cardiovasc Res 79:600-10. 2008
    ..Since ER stress is involved in the development of heart failure, we investigated the role of ER-initiated cardiomyocyte death by proteasome inhibition...
  51. pmc Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78
    Marina S Gorbatyuk
    Department of Molecular Genetics, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 107:5961-6. 2010
    ..In P23H rats, photoreceptor levels of cleaved ATF6, pEIF2alpha, CHOP, and caspase-7 were much higher than those of wild-type rats...
  52. pmc The unfolded protein response in melanocytes: activation in response to chemical stressors of the endoplasmic reticulum and tyrosinase misfolding
    Prashiela Manga
    The Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA
    Pigment Cell Melanoma Res 23:627-34. 2010
    ..ER) triggers the unfolded protein response (UPR), comprising three signaling pathways initiated by Ire1, Perk and Atf6 respectively...
  53. doi Atypical induction of the unfolded protein response by mifepristone
    N Dioufa
    Department of Biochemistry, University of Athens Medical School, M Asias 75, 115 27, Athens, Greece
    Endocrine 38:167-73. 2010
    ..of RNA levels of the chaperone Grp94 and PDIa, as well as the endoplasmic reticulum stress-associated receptors ATF6, PERK and eIF2 but not of their downstream target, transcription factor ATF4...
  54. pmc Brain-derived neurotrophic factor suppresses tunicamycin-induced upregulation of CHOP in neurons
    Gang Chen
    Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C Byrd Health Sciences Center, Morgantown, West Virginia 26506, USA
    J Neurosci Res 85:1674-84. 2007
    ..induction, which includes the activation of transcription factors such as activating transcriptional factor 6 (ATF6) and C/EBP homologous protein (CHOP, also known as growth arrest and DNA damage-inducible gene 153 [GADD153])...
  55. pmc Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathways
    Jennifer J Wolfson
    Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, Boston, MA 02111, USA
    Cell Microbiol 10:1775-86. 2008
    ..The rapidity with which ER stress-signalling responses are triggered by exposure of cells to SubAB is consistent with the hypothesis that cleavage by the toxin causes BiP to dissociate from the signalling molecules...
  56. doi Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes
    Nian Wang
    Department of Pathophysiology, Medical College of Wuhan University, Hubei Provincial Key Laboratory of Allergy and Immune Related Diseases, Wuhan, People s Republic of China
    Mol Cell Endocrinol 307:89-98. 2009
    ..Activating transcription factor 6 (ATF6) was an ER stress regulated transmembrane transcription factor that activated the transcription of ER molecular ..
  57. doi Calnexin phosphorylation: linking cytoplasmic signalling to endoplasmic reticulum lumenal functions
    Eric Chevet
    Avenir, INSERM U889, Universite Victor Segalen Bordeaux 2, F 33076 Bordeaux, France
    Semin Cell Dev Biol 21:486-90. 2010
    ..presence of unfolded proteins from the lumen of the ER is mediated by the three ER membrane sensor proteins Ire1, ATF6 and PERK...
  58. ncbi A time-dependent phase shift in the mammalian unfolded protein response
    Hiderou Yoshida
    Graduate School of Biostudies, Kyoto University, Kyoto 606 8304, Japan
    Dev Cell 4:265-71. 2003
    ..The ATF6 and IRE1-XBP1 pathways are important for the refolding process in mammalian cells; activation of these ..
  59. pmc Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response
    Jingshi Shen
    Department of Biological Sciences, Columbia University, Fairchild 813B, MC 2420, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Mol Cell Biol 25:921-32. 2005
    Endoplasmic reticulum (ER) stress-induced activation of ATF6, an ER membrane-bound transcription factor, requires a dissociation step from its inhibitory regulator, BiP...
  60. pmc Dynamic recruitment of transcription factors and epigenetic changes on the ER stress response gene promoters
    Giacomo Donati
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita di Milano, Via Celoria 26, 20133 Milano, Italy
    Nucleic Acids Res 34:3116-27. 2006
    ..Most genes are bound by XBP-1 after induction, some before induction, presumably by the inactive isoform. ATF6 and CHOP associate to largely different set of genes...
  61. ncbi [Unfolded protein response: its role in physiology and physiopathology]
    Fabienne Foufelle
    INSERM U671, Universite Pierre et Marie Curie Paris 6, UMR S671, Centre Biomédical des Cordeliers, France
    Med Sci (Paris) 23:291-6. 2007
    ..transmembrane proteins of the ER : the PKR-like ER protein kinase (PERK), the activating transcription factor 6 (ATF6) and the inositol requiring enzyme 1 (IRE-1)...
  62. doi Endoplasmic reticulum stress induced by aqueous extracts of cigarette smoke in 3T3 cells activates the unfolded-protein-response-dependent PERK pathway of cell survival
    Arnd Hengstermann
    Philip Morris Research Laboratories GmbH, Fuggerstr 3, D 51149 Cologne, Germany
    Free Radic Biol Med 44:1097-107. 2008
    ..e., ATF6 and IRE1...
  63. doi [Some factors, with an impact on the outcome of the Hungarian Liver Transplant Program, with special consideration of the hepatitis C virus]
    Balazs Nemes
    Semmelweis Egyetem, Transzplantációs és Sebészeti Klinika, 1082 Budapest, Baross u 23
    Magy Seb 61:42-7. 2008
    ..All chaperones (XBP1, ATF6, HSP70, GRP98, GP96, Calnexin and Calreticulin) were upregulated in the graft biopsies of HCV positive patients, ..
  64. pmc Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis
    M Wang
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9176, USA
    Cell Death Differ 17:488-98. 2010
    ..Our studies uncover a novel link between GRP78 depletion and reduction in cytosolic ubiquitination and establish a novel mouse model of accelerated cerebellar degeneration with basic and clinical applications...
  65. doi Different mechanisms of recognition and ER retention by transmembrane transcription factors CREB-H and ATF6
    Marta Llarena
    Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, UK
    Traffic 11:48-69. 2010
    CREB-H and activating transcription factor 6 (ATF6) are transmembrane transcription factors that, in response to endoplasmic reticulum (ER) stress, traffic to the Golgi where they are cleaved by specific proteases, producing the N-..
  66. pmc EBNA3C interacts with Gadd34 and counteracts the unfolded protein response
    Jose L Garrido
    University of Pittsburgh and Children s Hospital of Pittsburgh, One Children s Hospital Drive, 4401 Penn Ave, Pittsburgh, PA 15224, USA
    Virol J 6:231. 2009
    ..of the unfolded protein response as measured by XBP1 (u) versus XBP1(s) protein expression and N-terminal ATF6 cleavage...
  67. ncbi Cross-talk of intracellular calcium stores in the response to neuronal ischemia and ischemic tolerance
    Jan Lehotsky
    Department of Medical Biochemistry, Comenius University, Jessenius Faculty of Medicine, SK 03601, Martin, Slovakia
    Gen Physiol Biophys 28:F104-14. 2009
    ..by preischemic treatment by the increased expression of Ca(2+) binding protein: GRP 78 and transcriptional factor ATF6 in reperfusion times...
  68. doi Exercise training increases hepatic endoplasmic reticulum (er) stress protein expression in MTP-inhibited high-fat fed rats
    Natalie Ann Chapados
    Department of Kinesiology, University of Montreal, Montreal, Quebec, Canada
    Cell Biochem Funct 28:202-10. 2010
    ..01). MTPX injection in HF but not in SD-fed animals resulted in an increase in BiP/GRP78, ATF6, PERK, and XBP-1 mRNA levels, (p < 0...
  69. doi Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses
    Rieko Setsuie
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurochem Int 56:911-8. 2010
    ..In this study, we show that skeletal muscles of Uchl3(-/-) mice exhibit the up-regulation of cleaved ATF6, Grp78, and PDI as well as HSP27, HSP70, HSP90 and HSP110, which indicate the induction of stress responses...
  70. doi Activation of ER stress and apoptosis by hydrogen peroxide in HeLa cells: protective role of mild heat preconditioning at 40°C
    Pragathi Pallepati
    Départment des sciences biologiques and TOXEN, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    Biochim Biophys Acta 1813:1987-99. 2011
    ..min) of cells to H(2)O(2) (15-50 μM) activated the UPR: expression of p-PERK, p-eIF2α and p-IRE1α increased, and ATF6 cleavage occurred...
  71. doi InterfERing with endoplasmic reticulum stress
    Honorata Kraskiewicz
    National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland
    Trends Pharmacol Sci 33:53-63. 2012
    ..ER stress: the protein kinase RNA-activated (PKR)-like ER kinase (PERK) arm, the activated transcription factor 6 (ATF6) arm and the inositol-requiring enzyme 1 (IRE1) arm...
  72. doi Sensing endoplasmic reticulum stress
    Vipul M Parmar
    School of Biological and Biomedical Sciences, Durham University, Durham, UK
    Adv Exp Med Biol 738:153-68. 2012
    ..Mis- or unfolded proteins are sensed by specialized ER stress sensors, such as IRE1, PERK and ATF6, which initiate several cellular responses and signaling pathways to restore ER homeostasis...
  73. doi Binding of human BiP to the ER stress transducers IRE1 and PERK requires ATP
    Si Nga Sou
    Centre for Process Systems Engineering, Department of Chemical Engineering and Chemical Technology, Imperial College, London SW7 2AZ, United Kingdom
    Biochem Biophys Res Commun 420:473-8. 2012
    ..ATP, but not ADP, was required to isolate the BiP-IRE1 and the BiP-PERK complexes, but the BiP-ATF6 complex was purified in all conditions tested...
  74. doi Endoplasmic reticulum stress is involved in granulosa cell apoptosis during follicular atresia in goat ovaries
    Pengfei Lin
    Key Laboratory of Animal Reproductive Endocrinology and Embryo Biotechnology of the Ministry of Agriculture, College of Veterinary Medicine, Northwest A and F University, Yangling, Shaanxi, China
    Mol Reprod Dev 79:423-32. 2012
    ..Activating transcription factor-6 (ATF6) and ATF4 mRNAs were significantly increased during granulosa cell apoptosis in vivo; in contrast to ATF6, ATF4 ..
  75. pmc 6-Shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress
    Rong Hu
    State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China
    PLoS ONE 7:e39664. 2012
    ..However, the effect on the other two UPR sensors IRE1 and ATF6 was not obvious...
  76. pmc Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress
    Sayuri Takayanagi
    Department of Life Sciences, Meiji University, 1 1 1 Higashimita, Tama ku, Kawasaki, Kanagawa, 214 8571, Japan
    Cell Stress Chaperones 18:11-23. 2013
    ..PKR-like endoplasmic reticulum kinase (PERK), inositol-requiring 1 (IRE1), activating transcription factor 6 (ATF6), and ATF4...
  77. ncbi Unfolded protein response
    Stewart Siyan Cao
    Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA Department of Biological Chemistry, University of Michigan Medical Center, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Curr Biol 22:R622-6. 2012
    ..This unfolded protein response (UPR) increases the ER protein-folding capacity, reduces global protein synthesis, and enhances ERAD of misfolded proteins...
  78. doi Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78
    H Y Tsai
    1 Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, Taiwan 2 Genomics Research Center, Academia Sinica, Taipei, Taiwan
    Oncogene 32:4921-31. 2013
    ..Our results also indicated that RRBP1 may involve in the regulation of mRNA stability of UPR components including ATF6 and GRP78. Taken together, RRBP1 could alleviate ER stress and help cancer cell survive...
  79. doi Endoplasmic reticulum stress signaling: the microRNA connection
    Marion Maurel
    Inserm U1053, Bordeaux, France
    Am J Physiol Cell Physiol 304:C1117-26. 2013
    ..ER-resident stress sensors, namely PKR-like endoplasmic reticulum kinase (PERK), activating transcription factor 6 (ATF6), and inositol requiring enzyme 1 (IRE1)...
  80. pmc Expression of autophagy and UPR genes in the developing brain during ethanol-sensitive and resistant periods
    Alexander Alimov
    Department of Molecular and Biochemical Pharmacology, University of Kentucky College of Medicine, 132 Health Sciences Research Building, 1095 Veterans Drive, Lexington, KY, 40536, USA
    Metab Brain Dis 28:667-76. 2013
    ..was much higher on PD4 than PD12; in contrast, the expression of genes that regulate UPR and autophagy, such as atf6, atg4, atg9, atg10, beclin1, bnip3, cebpb, ctsb, ctsd, ctss, grp78, ire1α, lamp, lc3 perk, pik3c3, and sqstm1 was ..
  81. doi Calnexin silencing in mouse neonatal cardiomyocytes induces Ca2+ cycling defects, ER stress, and apoptosis
    Nicolas Bousette
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada
    J Cell Physiol 229:374-83. 2014
    ..CNX silenced cardiomyocytes exhibited ER stress as evidenced by increased GRP78 and ATF6 protein levels, increased levels of spliced XBP1 mRNA, ASK-1, ERO1a, and CHOP mRNA levels...
  82. pmc Zhangfei/CREB-ZF - a potential regulator of the unfolded protein response
    Rui Zhang
    Department of Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    PLoS ONE 8:e77256. 2013
    ..UPR are regulated by three basic leucine-zipper (bLZip) motif-containing transcription factors - Xbp1s, ATF4 and ATF6. A failure of the UPR to achieve homeostasis and its continued stimulation leads to apoptosis...
  83. doi 14 The Role of ER Stress in Vascular Calcification
    M Furmanik
    King s College London, Cardiovascular Division, James Black Centre, London, UK
    Heart 100:A5-6. 2014
    ..pathway called the unfolded protein response (UPR), mediated by three main ER stress transducers IRE1, PERK and ATF6. ER stress has been implicated in bone development...
  84. doi Liraglutide alleviates diabetic cardiomyopathy by blocking CHOP-triggered apoptosis via the inhibition of the IRE-α pathway
    Yuqiang Ji
    Department of Cardiovascular Medicine, First Hospital of Xi an, Xi an, Shaanxi 710002, P R China
    Mol Med Rep 9:1254-8. 2014
    ..ER stress unfolded protein response (UPR) hallmarks [inositol-requiring enzyme-α (IRE-α), p-Perk and ATF6] and transcription factors were detected with western blotting...
  85. doi The PERK-eIF2α signaling pathway is involved in TCDD-induced ER stress in PC12 cells
    Zhiqing Duan
    Department of Nutrition and Food Hygiene, School of Public Health, Nantong University, Nantong, 226001 Jiangsu, People s Republic of China
    Neurotoxicology 44:149-59. 2014
    ..contrast, TCDD did not appear to affect inositol-requiring enzyme 1 (IRE1) and activating transcription factor 6 (ATF6), two other UPR sensors...
  86. doi [Bone and Calcium Research Update 2015. The regulation of proliferation and differentiation by the ER stress transducer in chondrocytes]
    Kazunori Imaizumi
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Clin Calcium 25:29-36. 2015
    BBF2H7 is an ER-resident transmembrane transcription factor which is structurally similar to ATF6, one of the canonical ER stress transducers, and preferentially expresses in chondrocytes...
  87. pmc Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival
    F Walter
    Centre for Systems Medicine and Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    Cell Death Differ 22:1502-16. 2015
    ..the unfolded protein response (UPR) mediated via the activation of three transmembrane proteins IRE1, PERK and ATF6. Signalling through these proteins is aimed at enhancing the ER folding capacity and reducing the folding load...
  88. pmc Activation of the Unfolded Protein Response in Sporadic Inclusion-Body Myositis but Not in Hereditary GNE Inclusion-Body Myopathy
    Anna Nogalska
    From the USC Neuromuscular Center, Department of Neurology, University of Southern California Keck School of Medicine, Good Samaritan Hospital, Los Angeles, California AN, CDA, WKE, MC, VA and Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan SA, km
    J Neuropathol Exp Neurol 74:538-46. 2015
    ..transcription factor 4 (ATF4) protein and increased mRNA of its target C/EBP homologous protein; 2) cleavage of the ATF6 and increased mRNA of its target glucose-regulated protein 78; and 3) an increase of the spliced form of X-box ..
  89. doi Activation of endoplasmic reticulum stress is involved in the activity of icariin against human lung adenocarcinoma cells
    Shouyin Di
    Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Road, Xi an, 710038, China
    Apoptosis 20:1229-41. 2015
    ..Furthermore, ICA treatment increased the expression of ERS-related molecules (p-PERK, ATF6, GRP78, p-eIF2α, and CHOP), up-regulated the apoptosis-related protein PUMA and down-regulated the anti-apoptosis-..
  90. doi Bicyclol attenuates tetracycline-induced fatty liver associated with inhibition of hepatic ER stress and apoptosis in mice
    Xiao Min Yao
    a Faculty of Pharmacy, Zhejiang Pharmaceutical College, Ningbo 315100, PR China
    Can J Physiol Pharmacol 94:1-8. 2016
    ..The gene expressions of ER stress-related markers, including CHOP, GRP78, IRE-1α, and ATF6, which were downregulated by bicyclol pretreatment in tetracycline-injected mice...
  91. pmc HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response
    Pattranuch Chusri
    Liver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Sci Rep 6:22487. 2016
    ..UPR is directed by three ER transmembrane proteins including ATF6, IRE1, and PERK. HCV increases TGF-β1 and oxidative stress, which play important roles in liver fibrogenesis...
  92. pmc NOD1 and NOD2 signalling links ER stress with inflammation
    A Marijke Keestra-Gounder
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Ave, Davis, California 95616, USA
    Nature 532:394-7. 2016
    ..ER stress induces the unfolded protein response, which involves activation of three transmembrane receptors, ATF6, PERK and IRE1α...
  93. ncbi Oxidative stress caused by a SOD1 deficiency ameliorates thioacetamide-triggered cell death via CYP2E1 inhibition but stimulates liver steatosis
    Takaya Shirato
    Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, 2 2 2 Iidanishi, Yamagata, 990 9585, Japan
    Arch Toxicol . 2016
    ..Both cleaved ATF6, a transcriptional regulator that is activated by endoplasmic reticulum (ER) stress, and CHOP, a death signal ..
  94. doi Targeting the angio-proteostasis network: Combining the forces against cancer
    Lindsey Devisscher
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Pharmacol Ther 167:1-12. 2016
    ..between angiogenic factors such as VEGF-A or PlGF and the individual members of the UPR such as IRE1, PERK and ATF6. We further describe how this interaction does not only affect the cancer cells, but also the surrounding ..
  95. pmc Unveiling the Role of the Integrated Endoplasmic Reticulum Stress Response in Leishmania Infection - Future Perspectives
    K L Dias-Teixeira
    Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Front Immunol 7:283. 2016
    ..ER kinase (PERK) that phosphorylates the eukaryotic translation initiation factor 2 and transcription factor 6 (ATF6). The roles of IRE-1, PERK, and ATF4 in viral and some bacterial infections are well characterized...
  96. doi Astragalus polysaccharide modulates ER stress response in an OVA-LPS induced murine model of severe asthma
    Yuan Lu
    Pediatric Institution of Nanjing University of Chinese Medicine, Nanjing, 210023, China Jiangsu Key Laboratory of Pediatric Respiratory Disease, Nanjing, 210023, China
    Int J Biol Macromol 93:995-1006. 2016
    ..Moreover, APS substantially blocks the nuclear translocation of ATF6 and NF-κB p65...
  97. doi Activation of UPR Signaling Pathway is Associated With the Malignant Progression and Poor Prognosis in Prostate Cancer
    Junnan Liu
    Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Prostate 77:274-281. 2017
    Currently, the role of UPR signaling in prostate cancer (PCa) is unclear. To evaluate the relationship between UPR signaling pathway and the prognosis of PCa, we explored the expression of IRE1, PERK, and ATF6 in tissues.
  98. ncbi Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis
    S Tsutsumi
    Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Cell Death Differ 11:1009-16. 2004
    ..Three factors that positively regulate CHOP expression (ATF6, ATF4 and XBP-1) were activated and/or induced by indomethacin...
  99. doi Coping with the stress: expression of ATF4, ATF6, and downstream targets in organs of hibernating ground squirrels
    Hapsatou Mamady
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ont, Canada K1S 5B6
    Arch Biochem Biophys 477:77-85. 2008
    ..The responses of other proteins involved in the UPR including p-PERK, ATF6, GADD153, and GADD34 were also evaluated...
  100. pmc CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade
    Imran N Mungrue
    Department of Medicine, University of California at Los Angeles, CA 90095, USA
    J Immunol 182:466-76. 2009
    ..of CHAC1 by the ATF4-ATF3-CHOP (C/EBP homologous protein), and not parallel XBP1 (X box-binding protein 1) or ATF6 pathways, using siRNA and/or overexpression plasmids...
  101. pmc Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells
    Yoon Mi Cho
    Department of Biochemistry, 2MRC for Cell Death Disease Research Center, Korea
    Exp Mol Med 41:440-52. 2009
    ..BIP/GRP78 protein expression was time-dependently increased, and three branches of UPR were all activated. ATF6 increased the transcription of XBP1 which was successfully spliced by IRE1...

Research Grants45

  1. Structure and Function of Proteins in Unfolded Protein Response
    Zhaohui Xu; Fiscal Year: 2005
    ..A class of novel ER trans-membrane receptors including IRE1, PERK, and ATF6 mediate activation of the UPR...
  2. Fatty acid synthase inhibitors and prostate cancer
    Steven J Kridel; Fiscal Year: 2010
    ..embryonic fibroblasts (MEFs) with pathway specific mutations to determine the contribution of the PERK, IRE1 and ATF6 signaling pathways to the ER stress response when FAS is inhibited...
  3. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  4. CFTR Biogenesis and Function in Epithelia
    Zsuzsa Bebok; Fiscal Year: 2012
    ..The mechanism of repression involves DNA hypermethylation, histone deacetylation and the binding of ATF6, the UPR-activated transcription factor, to the CFTR minimal promoter...
  5. DHAN V KALVAKOLANU; Fiscal Year: 2014
    ..Notably, Activating transcription factor 6 (ATF6), a key regulator of endoplasmic reticulum-dependent stress responses, appears to regulate DAPK1 expression...
  6. Matthew M Lavail; Fiscal Year: 2014
    ..We found that three parallel branches of the UPR, governed by IRE1, ATF6 and PERK, behave significantly differently in time course and that these differences in the duration of their ..
  7. Mechanisms of ER stress - induced fatty liver
    D Thomas Rutkowski; Fiscal Year: 2013
    ..of genes involved in maintaining lipid homeostasis;mice genetically deficient in the ER stress-sensing protein ATF6[unreadable] fail to overcome ER stress, and become profoundly steatotic upon challenge...
  8. Scott R Whittemore; Fiscal Year: 2015
    ..The 3 pathways involved in the ERSR involve PERK, IRE1/XBP-1, and ATF6 signaling. Preliminary data demonstrate upregulation of all 3 ERSR pathways following SCI...
  9. Avoiding toxicity associated with MTP ablation
    M Mahmood Hussain; Fiscal Year: 2013
    ..Fifth, importance of the ER stress pathways will be substantiated using ATF6-/-, CHOP-/- and Alb-Cre-Ire11fl/fl mice fed MTP inhibitors...
  10. Restoration of Endoplasmic Reticulum Function in Experimental Stroke
    Wulf Paschen; Fiscal Year: 2013
    ..The objective here is to create transgenic animals expressing the short form of ATF6, a transcription factor required to restore impaired ER function...
  11. Role of ER Stress in the Pathogenesis of Primary Open Angle Glaucoma
    GULAB ZODE; Fiscal Year: 2013
    ..Specifically, the candidate will learn and generate new models of ER stress using Atf6[unreadable] and Chop knockout mice, generate induced pluripotent stem cells (iPSCs)-derived trabecular meshwork- ..
  12. DOROTHY EILEEN VATNER; Fiscal Year: 2016
    ..cardiac cell survival through a novel mechanism by enhancing the response to ER stress via the activation of ATF6 /GRP78 signaling...
  13. Scott R Whittemore; Fiscal Year: 2015
    ..The ERSR has three arms initiated by PERK, IRE1, ATF6, respectively...
  14. Donald B Jump; Fiscal Year: 2015
    ..Finally, elevated hepatic Elovl5 activity attenuated stress pathways ([ER-stress, XBP1 and ATF6];NFkB, Jnk &p38) and induced the anti-oxidant enzyme, i.e., hemeoxygenase-1 (HMOX1)...
  15. Role of aberrant organelle stress responses in alcohol-induced liver injury
    Cheng Ji; Fiscal Year: 2012
    ..PCR (qPCR) and ChIP assays, we will study the recruitment of promoter specific transcription factors (XBP-1, CHOP, ATF6, ATF4, CREB, TORC3, PGC-1a), general transcription factors (Pol II, NF-Y, NFR, Sp1, TBP and p300) and epigenetic ..
  16. Randal J Kaufman; Fiscal Year: 2016
    ..Upon accumulation of unfolded proteins in the lumen of the ER, PERK, IREIa, and ATF6a are activated to increase the capacity of the ER to meet the demand for increased protein folding and to increase ..
  17. Julio A Aguirre-Ghiso; Fiscal Year: 2016
    ..We also found that (ii) the TF ATF6a regulates the survival component of dormancy by controlling an alternative pathway to mTOR activation Indeed, ..
  18. KIRSTEN C SADLER EDEPLI; Fiscal Year: 2016
    ..use this to determine how steatosis caused by chronic UPR activation is reduced when one of the key UPR players, Atf6, is depleted whereas steatosis caused by acute UPR activation worsens with Atf6 depletion...
  19. Roles for ER Stress Inducible Cardiomyokines in the heart
    Christopher C Glembotski; Fiscal Year: 2013
    ..Using a genomics approach we identified a group of genes induced by the ATF6 branch of the ER stress response (ERSR) that encode proteins predicted to have para/autocrine effects on the heart...
  20. Robert W Simms; Fiscal Year: 2015
    ..associated with SSc-PAH, induces a stress/unfolded protein response (UPR), and that stress response genes, ATF4 and ATF6 are more broadly upregulated in SSc...
  21. CHARLES F GROSE; Fiscal Year: 2015
    ..expanded experimental approach directed toward the three sensor pathways that lead from ER stress to the UPR (IRE1, ATF6 and PERK)...
  22. Mobilization of lysosome anti-microbial defenses by the unfolded protein response
    MARY O'RIORDAN; Fiscal Year: 2013
    ..using physical and functional markers upon activation of the UPR;(2) define the role of the UPR sensors, Ire1, ATF6 and PERK in regulating specific aspects of lysosomal trafficking and function in response to innate immune signals ..
  23. Novel Mechanisms of ER Stress Regulation in Ageing and Diseased Heart
    DEANNA LEE BORCHARDT STEIGER; Fiscal Year: 2013
    ..A surge of new discoveries has led to the identification and characterization of IRE11, PERK, and ATF6, the highly conserved UPR machinery that maintains ER homeostasis...
  24. Dissection of SREBP/ATF6 crosstalk in alcohol-induced steatosis
    Deanna L Howarth; Fiscal Year: 2013
    ..This research proposal is based on preliminary data that suggests depletion of a key mediator of the UPR, ATF6, reduces alcoholic steatosis in larval zebrafish, a novel tool for studying ALD...
  25. David H Broide; Fiscal Year: 2016
    ..regulates expression of multiple epithelial pathways (inflammation, remodeling, repair), as well as the ER ATF6 pathway which together play an important role in the pathogenesis of asthma...
  26. Structure and Function of Proteins in the Unfolded Protein Response
    Zhaohui Xu; Fiscal Year: 2007
    ..A class of novel transmembrane ER stress sensors including IRE1, PERK, and ATF6 mediate activation of the UPR. Our current study will focus on the structure and function of IRE1 and PERK...
  27. The Unfolded Protein Response After Brain Ischemia
    DONALD DEGRACIA; Fiscal Year: 2006
    ..and resistant brain regions the activation of the UPR by characterizing activation of its three effectors ATF6, IRE1alpha, and PERK...
  28. Mitotic Checkpoint & Genomic Stability in Ovarian Cancer
    Dong Yan Jin; Fiscal Year: 2006
    ..Further elucidation of the causative roles of checkpoint defects for drug resistance will reveal novel strategies for combination therapy. [unreadable] [unreadable]..
  29. BAX/BAK control ER-mitochondria apoptotic crosstalk
    SCOTT OAKES; Fiscal Year: 2007
    ..The sponsor, Dr. Stanley J. Korsmeyer, is a world-leader in the field of apoptosis with a strong record of training successful basic investigators. [unreadable] [unreadable]..
  30. A Staged Strategy for Virus Identification and Discovery
    W Ian Lipkin; Fiscal Year: 2005
    ..Our initial focus will be two chronic diseases where specific viral taxa are associated and potentially implicated in pathogenesis: bronchioalveolar cell carcinoma and amyotrophic lateral sclerosis. ..
  31. ATF3 in Beta cell signaling, expression & destruction
    Tsonwin Hai; Fiscal Year: 2006
    ..Blood glucose levels and diabetes incidence will be analyzed to determine whether ATF3 knockout mice are less sensitive to STZ than wild type mice. [unreadable] [unreadable]..
  32. Mass Tag PCR Detection of Respiratory Pathogens
    W Ian Lipkin; Fiscal Year: 2004
    ..abstract_text> ..
  33. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2004
    ..Consistent with aims proposed in AI51292, our initial clinical application will be to analyze enteroviral serotypes implicated in human disease in North America. ..
  34. TUMOR GROWTH INHIBITION BY INTERFERON B AND RETINOIDS
    DHAN KALVAKOLANU; Fiscal Year: 2001
    ..This proposal is a translational study that provides a basis and the necessary reagents for future phase II trials with IFN/RA or other drug combinations for cancer therapy. ..
  35. Free Fatty Acids and Hepatic Insulin Resistance
    Guenther Boden; Fiscal Year: 2007
    ..These studies will hopefully provide much needed information relative to important details and mechanisms of FFA induced hepatic insulin resistance. [unreadable] [unreadable]..
  36. Intracellular signaling in anesthetic and hypoxic preconditioning of neurons
    Philip E Bickler; Fiscal Year: 2010
    ..The work will also identify why the aging brain may not be able to benefit from the neuroprotective actions of anesthetics or other preconditioning treatments. ..
  37. ROLES FOR P38 MAP KINASES IN CARDIAC MYOCYTE GROWTH
    CHRISTOPHER GLEMBOTSKI; Fiscal Year: 2003
    ..abstract_text> ..
  38. Fat Induced Insulin Resistance and Atherosclerosis
    Guenther Boden; Fiscal Year: 2007
    ..We believe that these studies will provide important new information relative to the mechanism by which obesity and FFAs cause IR and ASVD in human subjects. ..
  39. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    W Ian Lipkin; Fiscal Year: 2009
    ....
  40. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 2002
    ....
  41. ATF3 and iNOS in Islet Distruction and Graft Rejection
    Tsonwin Hai; Fiscal Year: 2010
    ..abstract_text> ..
  42. The ER Stress Response and ATF6 Activation in the Heart
    CHRISTOPHER GLEMBOTSKI; Fiscal Year: 2007
    ..One pro-survival branch of the ERSR is mediated by the ER membrane protein, ATF6 alpha...
  43. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2004
    ..4) Determine how opoptosis contributes to the neuropathology observed after neonatal infection. (5) Analyze regional changes in neurotransmitter systems following neonatal infection. ..
  44. FAT MEDIATED INSULIN SECRETION AND DIABETES IN ELDERLY
    Guenther Boden; Fiscal Year: 2003
    ..We hope that this project will help to better understand the mechanisms by which obesity contributes to the development of NIDDM. ..
  45. BORNA DISEASE VIRUS AND NEUROPSYCHIATRIC DISEASE
    WALTER LIPKIN; Fiscal Year: 2002
    ..This study will be the first to collect and process human sera and PBMC samples in clinical laboratories with no history of BDV research and dispense aliquots to a central laboratory for randomized, blinded analysis. ..