ATF5

Summary

Gene Symbol: ATF5
Description: activating transcription factor 5
Alias: ATFX, HMFN0395, cyclic AMP-dependent transcription factor ATF-5, cAMP-dependent transcription factor ATF-5, transcription factor ATFx
Species: human

Top Publications

  1. ncbi cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein
    M Nishizawa
    Osaka Bioscience Institute, Japan
    FEBS Lett 299:36-8. 1992
  2. doi E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3
    Ying Zhou
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China
    Cell Signal 20:942-8. 2008
  3. doi Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions
    Donghui Zhou
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 283:7064-73. 2008
  4. ncbi Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region
    Yujiro Watatani
    Laboratory of Environmental Molecular Physiology, School of Life Science, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo, Japan
    J Biol Chem 283:2543-53. 2008
  5. doi The 5'-untranslated region regulates ATF5 mRNA stability via nonsense-mediated mRNA decay in response to environmental stress
    Masaya Hatano
    Laboratory of Environmental Molecular Physiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan
    FEBS J 280:4693-707. 2013
  6. pmc Differential expression of two activating transcription factor 5 isoforms in papillary thyroid carcinoma
    Luisa Vicari
    IOM Ricerca srl, Viagrande CT, Italy
    Onco Targets Ther 9:6225-6231. 2016
  7. pmc Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons
    Shu Zong Wang
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 109:18589-94. 2012
  8. pmc p300-dependent acetylation of activating transcription factor 5 enhances C/EBPβ transactivation of C/EBPα during 3T3-L1 differentiation
    Yue Zhao
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, People s Republic of China
    Mol Cell Biol 34:315-24. 2014
  9. doi A cellular response protein induced during HSV-1 infection inhibits viral replication by interacting with ATF5
    Lianqiu Wu
    Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, 650118, China
    Sci China Life Sci 56:1124-33. 2013
  10. pmc RNA sequence reveals mouse retinal transcriptome changes early after axonal injury
    Masayuki Yasuda
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 9:e93258. 2014

Scientific Experts

  • J M Angelastro
  • Yves Castonguay
  • Paul Willi Vesely
  • Zhi Sheng
  • Zhenshan Wang
  • Lloyd Greene
  • Jeffrey L Mason
  • Qihan Li
  • Tamayuki Shinomura
  • Rudolph J Schrot
  • Takeshi Nishioka
  • David X Liu
  • Guangfu Li
  • Natalie A Ciaccio
  • Shigeru Takahashi
  • Yuji Takahashi
  • Yuanyan Wei
  • Victor C Yang
  • ANGELO ARIAS
  • Dongmeng Qian
  • Ming Hu
  • Bin Wang
  • Yujiro Watatani
  • Jianhai Jiang
  • Jianxin Gu
  • Xian Pan
  • Takashi Yamazaki
  • Donghui Zhou
  • Jennifer S Laurence
  • Natsumi Kimura
  • Yusuke I Shimizu
  • Hidenori Hirose
  • Xinhui Wang
  • Zenglin Pei
  • Christopher J Fiorese
  • Brygida Bisikirska
  • M Jargosch
  • Akihiro Nukuda
  • Luisa Vicari
  • Hande Login
  • Vladimir Potapov
  • Ze Yan Zhang
  • Solen Rocher
  • Xiao min Hua
  • Bhanupriya Madarampalli
  • Yue Zhao
  • Masayuki Yasuda
  • Kwi Hye Koh
  • Ling Li
  • Li Zhang
  • XinYuan Liu
  • Jinming Yang
  • Brian F Teske
  • Xiaojie Xu
  • Lianqiu Wu
  • Ryan P Dalton
  • Yidi Xu
  • Masaya Hatano
  • Jesús F Torres-Peraza
  • C Allen
  • Hae Young Lee
  • David Tai Leong
  • Soutarou Izumi
  • Giovanni Reddiconto
  • Xijun Liu
  • Aiping Chen
  • Shu Zong Wang
  • Alex V Kochetov
  • Mariko Umemura
  • Douglas Dluzen
  • Julie Rousseau
  • Lotte N Moens
  • Ronald C Wek
  • Hitoshi Takeda
  • Pius N Nde
  • Asako Ohmi
  • Hiroyuki Uekusa
  • Noriko Nakanishi
  • Liisa Tomppo
  • Hiroshi Satake
  • Ying Zhou
  • Jennifer W M Gho
  • Maya Pascual
  • Daijuro Tonaki
  • Prabha Sampath
  • Catherine A Thomas
  • Huai Chia Chuang
  • Hongjie Wang
  • Jh Hu
  • Sara E Monaco

Detail Information

Publications96

  1. ncbi cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein
    M Nishizawa
    Osaka Bioscience Institute, Japan
    FEBS Lett 299:36-8. 1992
    ..Three leucine-zipper proteins were isolated from mouse cDNA expression libraries by this method: NF-IL6, ATF4, and a novel ATF4-related ATFx. The interactions of these proteins with GPE1-BP may play key roles in G-CSF gene expression.
  2. doi E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3
    Ying Zhou
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China
    Cell Signal 20:942-8. 2008
    ..Cotransfection of SIAH1 could withdraw up-regulation of TGF-beta signaling by TRB3, suggesting SIAH1-induced degradation of TRB3 represents a potential regulatory mechanism for TGF-beta signaling...
  3. doi Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions
    Donghui Zhou
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 283:7064-73. 2008
    ..We show that the expression of the basic zipper transcriptional regulator ATF5 is induced in response to many different stresses, including endoplasmic reticulum stress, arsenite exposure, and ..
  4. ncbi Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region
    Yujiro Watatani
    Laboratory of Environmental Molecular Physiology, School of Life Science, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo, Japan
    J Biol Chem 283:2543-53. 2008
    ..We previously reported that ATF5 mRNA expression increased in response to amino acid limitation...
  5. doi The 5'-untranslated region regulates ATF5 mRNA stability via nonsense-mediated mRNA decay in response to environmental stress
    Masaya Hatano
    Laboratory of Environmental Molecular Physiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan
    FEBS J 280:4693-707. 2013
    We previously reported that activating transcription factor 5 (ATF5) mRNA increases in response to amino acid limitation, and that this increase is dependent on mRNA stabilization...
  6. pmc Differential expression of two activating transcription factor 5 isoforms in papillary thyroid carcinoma
    Luisa Vicari
    IOM Ricerca srl, Viagrande CT, Italy
    Onco Targets Ther 9:6225-6231. 2016
    Activating transcription factor 5 (ATF5) is a member of the activating transcription/cAMP response element-binding protein family of basic leucine zipper proteins that plays an important role in cell survival, differentiation, ..
  7. pmc Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons
    Shu Zong Wang
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 109:18589-94. 2012
    Activating transcription factor 5 (ATF5) is a member of the ATF/cAMP response element-binding family of transcription factors, which compose a large group of basic region leucine zipper proteins whose members mediate diverse ..
  8. pmc p300-dependent acetylation of activating transcription factor 5 enhances C/EBPβ transactivation of C/EBPα during 3T3-L1 differentiation
    Yue Zhao
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, People s Republic of China
    Mol Cell Biol 34:315-24. 2014
    ..In this study, we found that activating transcription factor 5 (ATF5) can bind to the promoter of C/EBPα via its direct interaction with C/EBPβ (which is mediated via the p300-..
  9. doi A cellular response protein induced during HSV-1 infection inhibits viral replication by interacting with ATF5
    Lianqiu Wu
    Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, 650118, China
    Sci China Life Sci 56:1124-33. 2013
    ..by inhibiting transcription of the viral genome by interacting with the cellular transcription factor, ATF5, via its N-terminal domain...
  10. pmc RNA sequence reveals mouse retinal transcriptome changes early after axonal injury
    Masayuki Yasuda
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 9:e93258. 2014
    ..expressed genes with RNA-seq, notably the endoplasmic reticulum (ER) stress-related genes Atf3, Atf4, Atf5, Chac1, Chop, Egr1 and Trb3, which were significantly upregulated...
  11. pmc Krüppel-like factor 9 promotes hepatic cytochrome P450 2D6 expression during pregnancy in CYP2D6-humanized mice
    Kwi Hye Koh
    Department of Pharmacy Practice K H K, H J, Department of Biopharmaceutical Sciences X P, H J, College of Pharmacy, and Department of Pediatrics W Z and Department of Microbiology and Immunology A M, College of Medicine, University of Illinois at Chicago, Chicago, Illinois and Laboratory of Epigenetics and Chromatin Dynamics, and Departments of Biology and Molecular Biology, Epigenomics Translational Program, Mayo Clinic Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota R U
    Mol Pharmacol 86:727-35. 2014
    ..As a result, seven transcription factors-activating transcription factor 5 (ATF5), early growth response 1 (EGR1), forkhead box protein A3 (FOXA3), JUNB, Krüppel-like factor 9 (KLF9), KLF10, and ..
  12. pmc Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1β-stimulated C/EBP signaling pathway
    Ze Yan Zhang
    College of Life Sciences, Wuhan University, Wuhan, China
    Mol Cell Biol 35:778-88. 2015
    ..NLK interacted with activating transcription factor 5 (ATF5) and inhibited the proteasome-dependent degradation of ATF5 in a kinase-independent manner...
  13. pmc Data-driven prediction and design of bZIP coiled-coil interactions
    Vladimir Potapov
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Comput Biol 11:e1004046. 2015
    ..Using this approach, we designed peptides to interact with the bZIP domains from human JUN, XBP1, ATF4 and ATF5. Testing more than 132 candidate protein complexes using a fluorescence resonance energy transfer assay confirmed ..
  14. pmc Validation of Genotyping-By-Sequencing Analysis in Populations of Tetraploid Alfalfa by 454 Sequencing
    Solen Rocher
    Centre de Recherche et de Développement sur les Sols et les Grandes Cultures, Agriculture et Agroalimentaire Canada, Quebec City QC, Canada
    PLoS ONE 10:e0131918. 2015
    ..sativa): the synthetic cultivar Apica (ATF0) and a derived population (ATF5) obtained after five cycles of recurrent selection for superior tolerance to freezing (TF)...
  15. pmc DNA methylation level of promoter region of activating transcription factor 5 in glioma
    Xiao min Hua
    Department of Microbiology, Qingdao University Medical College, Qingdao 266071, China
    J Zhejiang Univ Sci B 16:757-62. 2015
    ..Previous researches have shown that the expression level of activating transcription factor 5 (ATF5) was frequently increased in glioma and its acetylation level was related to glioma...
  16. doi The Stimulus-Dependent Gradient of Cyp26B1+ Olfactory Sensory Neurons Is Necessary for the Functional Integrity of the Olfactory Sensory Map
    Hande Login
    Department of Molecular Biology, Umea University, Umeå SE90187, Sweden
    J Neurosci 35:13807-18. 2015
    ..Initially, these effects are selective to the VL-most zone and correlate with reduced ATF5 expression and accumulation of OSNs that do not express ORs...
  17. pmc Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression
    Brygida Bisikirska
    Department of Systems Biology, Columbia University, New York, New York
    Cancer Res 76:664-74. 2016
    ..This analysis revealed FOXM1, TFDP1, ATF5, HMGA1, and NFYB to be candidate master regulators (MR) contributing to disease progression...
  18. doi Role of ATF5 in the invasive potential of diverse human cancer cell lines
    Akihiro Nukuda
    Transdisciplinary Life Science Course, Faculty of Advanced Life Science, Hokkaido University, N10 W8, Kita ku, Sapporo, 060 0810, Japan
    Biochem Biophys Res Commun 474:509-14. 2016
    Activating transcription factor 5 (ATF5) is a member of the ATF/cAMP response element-binding protein family. Our research group recently revealed that ATF5 expression increases the invasiveness of human lung carcinoma cells...
  19. doi ATF5 Connects the Pericentriolar Materials to the Proximal End of the Mother Centriole
    Bhanupriya Madarampalli
    Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, WA 99202, USA
    Cell 162:580-92. 2015
    ..Here, we show that ATF5 forms a characteristic 9-fold symmetrical ring structure in the inner layer of the PCM outfitting the proximal end ..
  20. doi Data integration for identification of important transcription factors of STAT6-mediated cell fate decisions
    M Jargosch
    Signal Transduction, German Rheumatism Research Center DRFZ, Berlin, Germany
    Genet Mol Res 15:. 2016
    ..g., Ar), Th17 (e.g., Etv6), or iTreg (e.g., Stat3 and Hif1a) cells. Moreover, our approach reveals 11 TFs (e.g., Atf5, Creb3l2, and Asb2) with unknown functions in Th cell differentiation...
  21. doi Human cytomegalovirus infection promotes the stemness of U251 glioma cells
    Xinhui Wang
    Department of Microbiology, Qingdao University Medical College, Qingdao, Shandong, 266071, PR China
    J Med Virol . 2016
    ..Transcription factor 5 (ATF5) is an anti-apoptotic protein that is highly expressed in malignant glioma...
  22. pmc The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR
    Christopher J Fiorese
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA BCMB Allied Program, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA
    Curr Biol 26:2037-43. 2016
    ..Here, we describe a mammalian transcription factor, ATF5, which is regulated similarly to ATFS-1 and induces a similar transcriptional response...
  23. pmc Transcriptomic and functional pathways analysis of ascorbate-induced cytotoxicity and resistance of Burkitt lymphoma
    Zenglin Pei
    Scientific Research Center, Shanghai Public Health Clinical Center, Jinshan District, Shanghai 201508, China
    Oncotarget 7:63950-63959. 2016
    ..expressed gene signatures for JLPR cells and JLPS cells, which differential expression levels of five genes (ATF5, CD79B, MHC, Myosin, and SAP18) in ascorbate-resistant cells were related to phosphoinositide 3 kinase, cdc42, DNA ..
  24. pmc Oncolytic measles virus strains have significant antitumor activity against glioma stem cells
    C Allen
    Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA
    Gene Ther 20:444-9. 2013
    ..patient-derived primary tumor GBM xenografts, and we characterized them for the GSC markers CD133, SOX2, Nestin, ATF5 and OLIG2...
  25. pmc The endoplasmic reticulum stress transducer BBF2H7 suppresses apoptosis by activating the ATF5-MCL1 pathway in growth plate cartilage
    Soutarou Izumi
    Department of Biochemistry, Institute of Biomedical and Health Sciences, University of Hiroshima, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan and
    J Biol Chem 287:36190-200. 2012
    ..TUNEL staining of the cartilage showed that apoptosis was promoted in Bbf2h7(-/-) chondrocytes. Atf5 (activating transcription factor 5), another member of the CREB/ATF family and an antiapoptotic factor, was also ..
  26. doi ATF5 is overexpressed in epithelial ovarian carcinomas and interference with its function increases apoptosis through the downregulation of Bcl-2 in SKOV-3 cells
    Aiping Chen
    Department of Gynecology, The Affiliated Hospital of Qingdao University Medical College, Qingdao, Shandong, China
    Int J Gynecol Pathol 31:532-7. 2012
    The activating transcription factor 5 (ATF5) is highly expressed in many kinds of tumors including glioblastoma and breast cancers, but its expression in epithelial ovarian neoplasms has not been investigated...
  27. ncbi Interference with ATF5 function enhances the sensitivity of human pancreatic cancer cells to paclitaxel-induced apoptosis
    Ming Hu
    Department of Neural and Behavioral Sciences, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Anticancer Res 32:4385-94. 2012
    ..that human glioblastomas and breast cancer cells invariably express the activating transcription factor 5 (ATF5) and that loss of function of ATF5 caused massive apoptotic death of all cancer cell lines tested...
  28. ncbi ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase
    C S Peters
    Department of Medicine, Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia 19104 6145, USA
    J Biol Chem 276:13718-26. 2001
    ....
  29. doi Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus
    Jesús F Torres-Peraza
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, C Nicolás Cabrera, 1, Campus UAM de Cantoblanco, 28049 Madrid, Spain
    Brain 136:1161-76. 2013
    Activating transcription factor 5 (ATF5) is a basic-leucine-zipper transcription factor of the ATF/CREB family...
  30. pmc CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis
    Brian F Teske
    Department of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Mol Biol Cell 24:2477-90. 2013
    ..inhibition, CHOP enhances the expression of a collection of genes encoding transcription regulators, including ATF5, which is preferentially translated during eIF2 phosphorylation...
  31. doi Intron-length polymorphism identifies a Y2K4 dehydrin variant linked to superior freezing tolerance in alfalfa
    Yves Castonguay
    Crops and Soils Research and Development Center, Agriculture and Agri Food Canada, 2560 Hochelaga Blvd, Quebec, QC, Canada
    Theor Appl Genet 124:809-19. 2012
    ..the intron confirmed an increase in the number of fragments with small introns in the D+ progeny and in the ATF5 population obtained after five cycles of recurrent selection for superior TF within the cultivar Apica (ATF0)...
  32. ncbi Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib
    Reshma Shringarpure
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Br J Haematol 134:145-56. 2006
    ..We showed that overexpression of activating transcription factor 3 (ATF3), ATF4, ATF5, c-Jun, JunD and caspase-3 is associated with sensitivity to bortezomib-induced apoptosis, whereas overexpression ..
  33. pmc Histology-based expression profiling yields novel prognostic markers in human glioblastoma
    Shumin Dong
    Department of Pathology, Cancer Center and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston, 02129, USA
    J Neuropathol Exp Neurol 64:948-55. 2005
    ..A set of RNAs (including POFUT2, PTDSR, PLOD2, ATF5, and HK2) that were differentially expressed in 3 initially studied, microdissected glioblastomas also provided ..
  34. pmc The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription
    Eva Forgacs
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, USA
    J Virol 79:6932-9. 2005
    ..We have identified a cellular repressor of transcription, activating transcription factor x (ATFx), as a novel Tax-binding protein...
  35. pmc Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses
    Liisa Tomppo
    Institute for Molecular Medicine Finland FIMM and National Public Health Institute, Helsinki, Finland
    Biol Psychiatry 65:1055-62. 2009
    ..Because both DISC1 and NDE1 display association in our study sample, we hypothesized that other genes interacting with DISC1 might also have a role in the etiology of schizophrenia...
  36. doi Targeting of GSK3β promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells
    Giovanni Reddiconto
    Hematology Unit, Vito Fazzi Hospital Azienda Sanitaria Locale Leece, Italy
    Blood 119:2335-45. 2012
    ..transcription program in the nucleus of IM-treated CML cells by affecting the β-catenin, cyclinD1, C-EBPα, ATF5, mTOR, and p27 levels...
  37. pmc Reciprocal actions of ATF5 and Shh in proliferation of cerebellar granule neuron progenitor cells
    Hae Young Lee
    Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Dev Neurobiol 72:789-804. 2012
    ..The transcription factor ATF5 promotes proliferation of cerebral cortical neuroprogenitor cells and its down regulation permits their ..
  38. doi ATF5, a possible regulator of osteogenic differentiation in human adipose-derived stem cells
    David Tai Leong
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117456, Singapore
    J Cell Biochem 113:2744-53. 2012
    ..From our statistical analysis, we found activating transcription factor 5 (ATF5) to be significantly and consistently down-regulated in a randomized time-course study of osteogenically ..
  39. pmc Influence of the valine zipper region on the structure and aggregation of the basic leucine zipper (bZIP) domain of activating transcription factor 5 (ATF5)
    Natalie A Ciaccio
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, United States
    Mol Pharm 9:3190-9. 2012
    ..We have previously reported the use of the basic leucine zipper (bZIP) domain of activating transcription factor 5 (ATF5) as a partially folded model system to investigate protein aggregation...
  40. pmc Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells
    Xijun Liu
    Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 287:19599-609. 2012
    Nucleophosmin (NPM1/B23) and the activating transcription factor 5 (ATF5) are both known to subject to cell type-dependent regulation...
  41. doi Possible link between the synthesis of GR alpha isoforms and eIF2 alpha phosphorylation state
    Alex V Kochetov
    Institute of Cytology and Genetics, Novosibirsk, Russia
    Med Hypotheses 79:709-12. 2012
    ..Since the sequence organization of GRα mRNA strongly resembles the cases of ATF4 or ATF5, the well-known examples of reinitiation-dependent synthesis of functional isoforms, we hypothesize that ..
  42. pmc Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis
    Xiaojie Xu
    Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, People s Republic of China
    J Clin Invest 123:630-45. 2013
    ..HPIP expression, leading to repression of AKT and ERK and subsequent inhibition of mTOR through the AKT/ERK/FOXO4/ATF5 pathway. HBx has been shown to play a critical role in the molecular pathogenesis of HBV-related HCC...
  43. pmc Co-opting the unfolded protein response to elicit olfactory receptor feedback
    Ryan P Dalton
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA 94158, USA
    Cell 155:321-32. 2013
    ..of the translation initiation factor eif2α causing selective translation of activating transcription factor 5 (ATF5). ATF5 induces the transcription of adenylyl cyclase 3 (Adcy3), which relieves the UPR...
  44. ncbi The role of ATF/CREB family members in cell growth, survival and apoptosis
    S P Persengiev
    Howard Hughes Medical Institute, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Apoptosis 8:225-8. 2003
    ..One particular ATF/CREB family member, ATFx, is an anti-apoptotic factor that plays an essential role in cell survival...
  45. ncbi DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation
    Jill A Morris
    Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA
    Hum Mol Genet 12:1591-608. 2003
    ..alpha-actinin2 and beta4-spectrin; and proteins which transduce signals from membrane receptors, including ATF4 and ATF5. Truncated mutant DISC1 fails to interact with ATF4, ATF5 or NUDEL...
  46. pmc ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia
    Julie Rousseau
    Research Center, Centre hospitalier universitaire Sainte Justine, Montreal, QC
    Blood 118:5883-90. 2011
    ..Asparagine synthetase (ASNS) and the basic region leucine zipper activating transcription factor 5 (ATF5) and arginosuccinate synthase 1 (ASS1) have been shown to mediate the antileukemic effect of asparaginase and to ..
  47. pmc Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population
    Lotte N Moens
    Applied Molecular Genomics Group, Department of Molecular Genetics, Flanders Institute for Biotechnology VIB, Flanders, Belgium
    PLoS ONE 6:e23450. 2011
    ..sequencing strategy, to explore the contribution of genetic variation in DISC1 and 10 of its interaction partners (ATF5, Grb2, FEZ1, LIS-1, PDE4B, NDE1, NDEL1, TRAF3IP1, YWHAE, and ZNF365) to schizophrenia susceptibility in an isolated ..
  48. pmc p300-Dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival
    David X Liu
    Departments of Neural and Behavioural Sciences, Penn State University College of Medicine, Hershey, PA 17033, USA
    Mol Cell Biol 31:3906-16. 2011
    b>ATF5 has been shown to be a critical regulator of cell proliferation and survival; however, the underlying mechanism remains largely unknown...
  49. doi SRAP polymorphisms associated with superior freezing tolerance in alfalfa (Medicago sativa spp. sativa)
    Yves Castonguay
    Crops and Soils Research and Development Center, Agriculture and Agri Food Canada, 2560 Hochelaga Blvd, Quebec, QC, G1V 2J3, Canada
    Theor Appl Genet 120:1611-9. 2010
    ..Bulk DNA samples (45 plants/bulk) from each of the cultivar Apica (ATF0), and populations ATF2, ATF4, ATF5, and ATF6 were evaluated with 42 different SRAP primer pairs...
  50. pmc BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription
    Zhi Sheng
    Howard Hughes Medical Institute, Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Blood 118:2840-8. 2011
    ..Here we report that in both mouse and human BCR-ABL-transformed cells, activating transcription factor 5 (ATF5), a prosurvival factor, suppresses autophagy but does not affect apoptosis...
  51. pmc HSP70 protein promotes survival of C6 and U87 glioma cells by inhibition of ATF5 degradation
    Guangfu Li
    Department of Neural and Behavioral Sciences, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 286:20251-9. 2011
    Although both the heat shock protein 70 (HSP70) and the activating transcription factor 5 (ATF5) have been shown to promote cell survival of transformed cells but not survival of non-transformed cells, the relationship of the two ..
  52. ncbi A physiologically based pharmacokinetic model characterizing mechanism-based inhibition of CYP1A2 for predicting theophylline/antofloxacin interaction in both rats and humans
    Xian Pan
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Drug Metab Pharmacokinet 26:387-98. 2011
    ..Our previous study showed antofloxacin (ATFX) was responsible for mechanism-based inhibition (MBI) of the metabolism of phenacetin in rats...
  53. pmc An activating transcription factor 5-mediated survival pathway as a target for cancer therapy?
    Zhi Sheng
    Howard Hughes Medical Institute, Program in Gene Function, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Oncotarget 1:457-60. 2010
    ..Activating transcription factor 5 (ATF5) is an anti-apoptotic protein that is highly expressed in malignant glioma but not normal brain tissues, and is ..
  54. ncbi The interaction of the SARS coronavirus non-structural protein 10 with the cellular oxido-reductase system causes an extensive cytopathic effect
    Qihan Li
    Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming 650118, PR China
    J Clin Virol 34:133-9. 2005
    ..The results indicated that apart from the two subunits of cellular RNA polymerase complex, BTF3 and ATF5, this nsp10 protein was also able to interact specifically with the NADH 4L subunit and cytochrome oxidase II...
  55. ncbi Possible multiple transporters were involved in hepatobiliary excretion of antofloxacin in rats
    Jh Hu
    Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Xenobiotica 37:579-91. 2007
    1. The aim of the current study was to investigate the characteristics of biliary excretion of antofloxacin (ATFX) in rats. Rats received a bolus intravenous injection followed by a constant-rate infusion of ATFX...
  56. ncbi ATF5 promotes cell survival through transcriptional activation of Hsp27 in H9c2 cells
    Hongjie Wang
    Department of Physiology and Pathophysiology, Peking University School of Basic Medical Science, Beijing 100083, China
    Cell Biol Int 31:1309-15. 2007
    ..Here we described that ATF5 could promote cell survival in heat shock stress and identified that heat shock protein 27 (Hsp27) as one of its ..
  57. ncbi Organotypic distribution of stem cell markers in formalin-fixed brain harboring glioblastoma multiforme
    Rudolph J Schrot
    Department of Neurological Surgery, UC Davis Medical Center, 4860 Y Street, Suite 3740, Sacramento, CA 95817, USA
    J Neurooncol 85:149-57. 2007
    ..explore this hypothesis, we examined the distribution of two stem cell markers, activating transcription factor 5 (ATF5) and CD133, in an autopsy brain specimen from an individual with glioblastoma multiforme...
  58. ncbi Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Neurosci Lett 417:316-21. 2007
    ..As interacting-proteins with DISC1, Nudel, ATF4, ATF5, LIS1, alpha-tubulin, PDE4B, eIF3, FEZ1, Kendrin, MAP1A and MIPT3 were identified...
  59. ncbi The transcription factor ATF5 is widely expressed in carcinomas, and interference with its function selectively kills neoplastic, but not nontransformed, breast cell lines
    Sara E Monaco
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Int J Cancer 120:1883-90. 2007
    b>ATF5, a transcription factor important in differentiation, proliferation and survival, has been found to be highly expressed in neural progenitor cells and in certain tumors including glioblastomas (GBMs), but its expression in other ..
  60. ncbi Amino acid limitation induces expression of ATF5 mRNA at the post-transcriptional level
    Yujiro Watatani
    Laboratory of Environmental Molecular Physiology, School of Life Science, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Life Sci 80:879-85. 2007
    b>ATF5 is a transcription factor in the cAMP response element (CRE)-binding protein/activating transcription factor (CREB/ATF) family. We studied the effect of amino acid limitation on ATF5 mRNA levels in a mammalian cell line...
  61. ncbi Screening for genes preferentially expressed in the early phase of chondrogenesis
    Tamayuki Shinomura
    Tissue Regeneration, Department of Hard Tissue Engineering, Tokyo Medical and Dental University, Japan
    Biochem Biophys Res Commun 341:167-74. 2006
    ..factors that were identified in differentiating cultures, and found that activating transcription factor 5, ATF5, exhibited a conspicuous activation pattern using two methods to induce chondrogenesis of ATDC5 cells...
  62. ncbi ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells
    Yuanyan Wei
    State Key Laboratory of Genetic Engineering and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai 200032, People s Republic of China
    Biochem Biophys Res Commun 339:591-6. 2006
    b>ATF5 transcription factor plays an essential role in hematopoietic and glioma cell survival and neuronal cell differentiation...
  63. ncbi Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5
    J M Angelastro
    Department of Pathology and Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Oncogene 25:907-16. 2006
    ..We found expression of the bZip transcription factor ATF5 in all 29 human glioblastomas and eight human and rat glioma cell lines assessed...
  64. ncbi Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP
    Jude Al Sarraj
    Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, D 66421 Homburg, Germany
    Biol Chem 386:873-9. 2005
    ..Here we show that overexpression of the bZIP protein ATF5, a transcriptional activator, stimulates asparagine synthetase promoter/reporter gene transcription via the ..
  65. ncbi Molecular basis of aggressive disease in chronic lymphocytic leukemia patients with 11q deletion and trisomy 12 chromosomal abnormalities
    Amit K Mittal
    Department of Genetics, University of Nebraska Medical Center, Omaha, NE 68198 6395, USA
    Int J Mol Med 20:461-9. 2007
    ..SAM) identified 27 differentially expressed genes between these two subgroups with significant overexpression of ATF5 and underexpression of CDC16, PCDH8, SLAM, MNDA and ATF2 in CLL patients with poor outcome...
  66. ncbi ATF5 regulates the proliferation and differentiation of oligodendrocytes
    Jeffrey L Mason
    Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Cell Neurosci 29:372-80. 2005
    The transcription factor ATF5 is expressed in cells of the embryonic and neonatal ventricular zone/subventricular zone (VZ/SVZ), and must be down-regulated for their differentiation into neurons and astrocytes...
  67. ncbi Downregulation of activating transcription factor 5 is required for differentiation of neural progenitor cells into astrocytes
    James M Angelastro
    Department of Pathology and Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 25:3889-99. 2005
    ..The transcription factor activating transcription factor 5 (ATF5) is expressed in neural progenitors of developing brain but is absent from mature astrocytes and neurons...
  68. ncbi Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity
    Wenjin Liu
    State Key Laboratory of Genetic Engineering and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai 200032, People s Republic of China
    Biochem Biophys Res Commun 321:954-60. 2004
    ..But Cyclin D1 and Cyclin D2 had no effect on hATF5 transcriptional activity. These data provide a new clue to understand the new role of Cyclin D3 as a transcriptional regulator...
  69. ncbi Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations
    Paloma Fernandez
    Lymphomas and Lung Cancer Laboratory, Spanish National Cancer Centre CNIO, Madrid, Spain
    Oncogene 23:5084-91. 2004
    ..g. FRAP1/mTOR, ARAF1 and ROCK2), cytoskeleton (e.g. MPP1), transcription factors (e.g. MEIS2, ATF5), metabolism of AMP (AMPD3 and APRT) and ubiquitinization (e.g. USP16 and UBE2L3)...
  70. ncbi Interaction of GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase with GDP-mannose-4,6-dehydratase stabilizes the enzyme activity for formation of GDP-fucose from GDP-mannose
    Ken ichi Nakayama
    Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 6, 1 1 Higashi, Tsukuba 305 8566, Japan
    Glycobiology 13:673-80. 2003
    We cloned the GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase gene from Arabidopsis thaliana (AtFX/GER1)...
  71. ncbi Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons
    James M Angelastro
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 23:4590-600. 2003
    ..We report that the bZIP transcription factor ATF5 plays a major regulatory role in this process...
  72. ncbi Mouse Atf5: molecular cloning of two novel mRNAs, genomic organization, and odorant sensory neuron localization
    Malene B Hansen
    Laboratory of Mammalian Molecular Genetics, The Panum Institute 6 5, University of Copenhagen, Denmark
    Genomics 80:344-50. 2002
    ..Here we describe two novel mRNAs encoding a single, 30-kDa mouse polypeptide, designated mouse ATF5, which is 58% identical to mouse ATF4 in the carboxy-terminal bZIP region...
  73. pmc Inhibition of apoptosis by ATFx: a novel role for a member of the ATF/CREB family of mammalian bZIP transcription factors
    Stephan P Persengiev
    Howard Hughes Medical Institute and Programs in Molecular Medicine and Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 16:1806-14. 2002
    ..Here we report that expression of a specific mouse ATF gene, ATFx, is down-regulated in a variety of cells undergoing apoptosis following growth factor deprivation...
  74. pmc The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx
    J H White
    Receptor Systems, Molecular Pharmacology Department, Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom
    Proc Natl Acad Sci U S A 97:13967-72. 2000
    ..between the C-terminal tails of GABA(B)-R1 and GABA(B)-R2 with two related transcription factors, CREB2 (ATF4) and ATFx. In primary neuronal cultures as well in recombinant Chinese hamster ovary cells expressing GABA(B) receptors, ..
  75. pmc Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis
    D Pati
    Texas Children s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 19:5001-13. 1999
    ..This degradation requires an active ubiquitin-conjugating enzyme and results in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription...
  76. pmc The transcription factor ATF5: role in neurodevelopment and neural tumors
    Lloyd A Greene
    Department of Pathology and Cell Biology Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurochem 108:11-22. 2009
    We review recent findings regarding the properties of ATF5 and the major roles that this transcription factor plays in development of the nervous system and in survival of neural tumors...
  77. doi Regulation of the human CHOP gene promoter by the stress response transcription factor ATF5 via the AARE1 site in human hepatoma HepG2 cells
    Takashi Yamazaki
    The Laboratory of Environmental Molecular Physiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
    Life Sci 87:294-301. 2010
    ..We have shown that ATF5 is a stress response transcription factor that responds to amino acid limitation, arsenite exposure, or cadmium ..
  78. pmc A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications
    Zhi Sheng
    Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Med 16:671-7. 2010
    Activating transcription factor-5 (ATF5) is highly expressed in malignant glioma and has a key role in promoting cell survival. Here we perform a genome-wide RNAi screen to identify transcriptional regulators of ATF5...
  79. pmc Gene network analysis during early infection of human coronary artery smooth muscle cells by Trypanosoma cruzi and Its gp83 ligand
    Pius N Nde
    Department of Microbiology and Immunology, School of Medicine, Meharry Medical College, 1005 Dr D B Todd Jr Blvd, Nashville, TN 37208 3599, USA
    Chem Biodivers 7:1051-64. 2010
    ..Using seven RT-PCR verified up-regulated genes (FOSB, ATF5, INPP1, CCND2, THBS1, LAMC1, and APLP2) as the seed for network construction, we built an interaction network of ..
  80. doi Identification and characterization of the promoter of human ATF5 gene
    Yuanyan Wei
    Key Laboratory of Glycoconjuates Research, Ministry of Public Health and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai, People s Republic of China
    J Biochem 148:171-8. 2010
    b>ATF5, a member of ATF/CREB family of b-ZIP transcription factors, is highly expressed in a wide variety of neoplasms and regulates cell differentiation, cell survival and apoptosis...
  81. doi Spatio-temporal expression of activating transcription factor 5 in the skeletal development of mouse limb
    Hiroshi Satake
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, Yamagata, Yamagata 990 9585, Japan
    Dev Growth Differ 51:669-76. 2009
    There are no data about the expression pattern of activating transcription factor 5 (Atf5) during limb development. The aim of the present study was to describe the expression of Atf5 throughout mouse limb development...
  82. pmc Identification of a novel DNA binding site and a transcriptional target for activating transcription factor 5 in c6 glioma and mcf-7 breast cancer cells
    Guangfu Li
    Department of Neural and Behavioral Sciences, Penn State University College of Medicine, Hershey, 17033, USA
    Mol Cancer Res 7:933-43. 2009
    Recent reports indicate that the activating transcription factor 5 (ATF5) is required for the survival of cancer cells but not for noncancer cells...
  83. pmc Effects of disulfide bond formation and protein helicity on the aggregation of activating transcription factor 5
    Natalie A Ciaccio
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, USA
    Mol Pharm 6:1205-15. 2009
    ..previously reported the isolation of the basic leucine zipper (bZIP) domain of activating transcription factor 5 (ATF5), a protein notable for its potential as a pharmaceutical target for treatment of glioblastoma multiforme...
  84. doi Fasting induced up-regulation of activating transcription factor 5 in mouse liver
    Yusuke I Shimizu
    Laboratory of Environmental Molecular Physiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192 0392, Japan
    Life Sci 84:894-902. 2009
    ..b>Atf5 (activating transcription factor 5) is a transcription factor of the ATF/cAMP response element-binding protein ..
  85. ncbi Novel function of transcription factor ATF5: blockade of p53-dependent apoptosis induced by ionizing irradiation
    Takeshi Nishioka
    Department of Biomedical Sciences and Engineering, Faculty of Health Sciences, Graduate School of Health Sciences, Hokkaido University, Sapporo, Japan
    Cell Struct Funct 34:17-22. 2009
    ..To find a new molecule that affects p53-dependent radiosensitivity...
  86. doi Cadmium interferes with the degradation of ATF5 via a post-ubiquitination step of the proteasome degradation pathway
    Hiroyuki Uekusa
    Laboratory of Environmental Molecular Physiology, School of Life Science, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Biochem Biophys Res Commun 380:673-8. 2009
    b>ATF5 is a member of the CREB/ATF family of transcription factors...
  87. pmc BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner
    Douglas Dluzen
    Department of Neural and Behavioral Sciences, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 286:7705-13. 2011
    b>ATF5 loss of function has been shown previously to cause apoptotic cell death in glioblastoma and breast cancer cells but not in non-transformed astrocytes and human breast epithelial cells...
  88. pmc Up-regulation of activating transcription factor-5 suppresses SAP expression to activate T cells in hemophagocytic syndrome associated with Epstein-Barr virus infection and immune disorders
    Huai Chia Chuang
    Division of Clinical Research, National Health Research Institutes, Tainan, Taiwan
    Am J Pathol 173:1397-405. 2008
    ..In this study, using cDNA microarray analysis, we identified ATF5 as the candidate transcriptional repressor for SAP expression in LMP-1-expressing T cells...
  89. pmc High-yield expression in E. coli and refolding of the bZIP domain of activating transcription factor 5
    Natalie A Ciaccio
    Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66047, USA
    Protein Expr Purif 62:235-43. 2008
    Activating transcription factor 5 (ATF5) recently has been demonstrated to play a critical role in promoting the survival of human glioblastoma cells...
  90. doi Re-expression of transcription factor ATF5 in hepatocellular carcinoma induces G2-M arrest
    Jennifer W M Gho
    Li Ka Shing Institute of Health Sciences, Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Cancer Res 68:6743-51. 2008
    ..Here, we report on the novel finding of common ATF5 down-regulations in hepatocellular carcinoma (HCC), a highly malignant tumor with a dismal clinical course...
  91. doi A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation
    Prabha Sampath
    Department of Pathology, Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA
    Cell Stem Cell 2:448-60. 2008
    ..Transcripts under exclusive translational control included the transcription factor ATF5, the tumor suppressor DCC, and the beta-catenin agonist Wnt1...
  92. doi Cdc34-mediated degradation of ATF5 is blocked by cisplatin
    Yuanyan Wei
    Gene Research Center, Key Laboratory of Medical Molecular Virology Ministry of Education and Health, Ministry of Public Health, Shanghai Medical College and Institutes of Biomedical Sciences of Fudan University, Shanghai, China
    J Biol Chem 283:18773-81. 2008
    b>ATF5, a member of activating transcription factor (ATF)/cAMP-response element-binding protein (CREB) family of b-ZIP transcription factors, contributes to neural cell differentiation and is involved in cell apoptosis in response to ..
  93. pmc (Z)-1,1-Dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane induces concentration-dependent growth inhibition, apoptosis, and coordinates regulation of apoptotic genes in TRAMP cells
    Catherine A Thomas
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Urol Oncol 26:378-85. 2008
    ..Microarray analyses showed Bok and Siva-pending to be up-regulated and that Birc, Dad1, and Atf5 were down-regulated...
  94. doi ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses
    Maya Pascual
    Unidad de Hepatologia Experimental, Centro de Investigacion, Hospital Universitario La Fe, Valencia, Spain
    Drug Metab Dispos 36:1063-72. 2008
    ..However, its role in the liver has not yet been investigated. We show herein that ATF5 is a highly abundant liver-enriched transcription factor (LETF) whose expression declines in correlation with the ..
  95. ncbi Evidence for circadian regulation of activating transcription factor 5 but not tyrosine hydroxylase by the chromaffin cell clock
    Dario R Lemos
    Division of Neuroscience, Oregon National Primate Research Center, 505 Northwest 185th Avenue, Beaverton, OR 97006, USA
    Endocrinology 148:5811-21. 2007
    ..several genes in a 24-h rhythmic pattern, including TH (the rate-limiting enzyme in catecholamine synthesis) and Atf5 (a transcription factor involved in apoptosis and neural cell differentiation) together with the core-clock genes...

Research Grants4

  1. Elimination of Carcinogen-Induced Tumor Stem Cells by ATF5 Loss of Function.
    JAMES ANGELASTRO; Fiscal Year: 2009
    Activating transcription factor 5 (ATF5) is highly expressed in neural stem/progenitor cells, and disappears when these cells differentiate into neurons and astrocytes...
  2. MION for Synchronized MRI and Drug Therapy of Brain Tumor
    Victor C Yang; Fiscal Year: 2010
    ..In principle, macromolecular drug (e.g. ATF5-siRNA) with unmatched glioma specificity and potency will be linked to the non-toxic cell-penetrating LMWP via ..
  3. Targeting ATF5 for intervention in brain cancer
    ANGELO ARIAS; Fiscal Year: 2009
    ..Preliminary results from our lab show that downregulation of Activating Transcription Factor 5 (ATF5), a cAMP response element binding protein, suppresses proliferation in cell culture...
  4. NEUROCHEMICAL STUDIES ON CULTURED NEURONS
    Lloyd Greene; Fiscal Year: 2002
    ..work will provide insight into a wide variety of key brain functions and has the potential to lead to design of pharmaceutical agents for the treatment and prevention of a number of maladies affecting the nervous system ..