ASS1

Summary

Gene Symbol: ASS1
Description: argininosuccinate synthase 1
Alias: ASS, CTLN1, argininosuccinate synthase, argininosuccinate synthetase 1, citrulline-aspartate ligase
Species: human

Top Publications

  1. ncbi Arginine metabolism and the synthesis of nitric oxide in the nervous system
    H Wiesinger
    Physiologisch chemisches Institut der Universität, Hoppe Seyler Strasse 4, D 72076, Tubingen, Germany
    Prog Neurobiol 64:365-91. 2001
  2. pmc Molecular structure of the human argininosuccinate synthetase gene: occurrence of alternative mRNA splicing
    S O Freytag
    Mol Cell Biol 4:1978-84. 1984
  3. ncbi Aberrant regulation of argininosuccinate synthetase by TNF-alpha in human epithelial ovarian cancer
    Peter W Szlosarek
    Cancer Research UK, Translational Oncology Laboratory, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Int J Cancer 121:6-11. 2007
  4. doi Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma
    Eisuke Kobayashi
    Chemotherapy Division, National Cancer Centre Research Institute, Chuo Ku, Tokyo, Japan
    Mol Cancer Ther 9:535-44. 2010
  5. ncbi Correction of argininosuccinate synthetase (AS) deficiency in a murine model of citrullinemia with recombinant adenovirus carrying human AS cDNA
    X Ye
    Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Gene Ther 7:1777-82. 2000
  6. ncbi Mild citrullinemia in Caucasians is an allelic variant of argininosuccinate synthetase deficiency (citrullinemia type 1)
    Johannes Haberle
    Universitatsklinikum Munster, Klinik und Poliklinik für Kinderheilkunde, Albert Schweitzer Strasse 33, D 48149 Munster, Germany
    Mol Genet Metab 80:302-6. 2003
  7. pmc Slc25a13-knockout mice harbor metabolic deficits but fail to display hallmarks of adult-onset type II citrullinemia
    David S Sinasac
    Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Mol Cell Biol 24:527-36. 2004
  8. ncbi Identification of two novel mutations in the SLC25A13 gene and detection of seven mutations in 102 patients with adult-onset type II citrullinemia
    T Yasuda
    Department of Biochemistry, Faculty of Medicine, Kagoshima University, Japan
    Hum Genet 107:537-45. 2000
  9. ncbi [Adult-onset citrullinemia]
    Shu Ichi Ikeda
    Department of Internal Medicine Neurology and Rheumatology, Shinshu University School of Medicine, Matsumoto, Japan
    Brain Nerve 59:59-66. 2007
  10. ncbi Genomic structure of the adult-onset type II citrullinemia gene, SLC25A13, and cloning and expression of its mouse homologue
    D S Sinasac
    Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Genomics 62:289-92. 1999

Research Grants

  1. Arginine Deprivation: A targeted therapy for Melanoma
    Lynn Feun; Fiscal Year: 2006
  2. Biomarker for liver ischemia/reperfusion-induced injury
    MONIKA OLI; Fiscal Year: 2006
  3. ASS, NOS2, AND ALCOHOLIC LIVER DISEASE
    Natalia Nieto; Fiscal Year: 2012
  4. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
  5. Recombinant hepatic argininosuccinate synthase (rASS) for treatment of sepsis/end
    Stanislav I Svetlov; Fiscal Year: 2012
  6. HEPATOCYTE GENE THERAPY FOR CITRULLINEMIA
    Brendan Lee; Fiscal Year: 2000
  7. ROBERT JOSEPH SHMOOKLER REIS; Fiscal Year: 2016
  8. Molecular Basis of mu-Opioid Receptor Gene Regulation
    Jane Ko; Fiscal Year: 2009
  9. Lisa Mosconi; Fiscal Year: 2014
  10. WGA as a Novel Vehicle for Intranasal Delivery of an Anti-A-beta Antibody in AD
    Neelima B Chauhan; Fiscal Year: 2012

Detail Information

Publications260 found, 100 shown here

  1. ncbi Arginine metabolism and the synthesis of nitric oxide in the nervous system
    H Wiesinger
    Physiologisch chemisches Institut der Universität, Hoppe Seyler Strasse 4, D 72076, Tubingen, Germany
    Prog Neurobiol 64:365-91. 2001
    ..Argininosuccinate synthetase (ASS) and argininosuccinate lyase which together can recycle the NOS coproduct L-citrulline to L-arginine are expressed ..
  2. pmc Molecular structure of the human argininosuccinate synthetase gene: occurrence of alternative mRNA splicing
    S O Freytag
    Mol Cell Biol 4:1978-84. 1984
    ..These observations show that splicing of the argininosuccinate synthetase mRNA is species specific in primates and varies among different human cell types...
  3. ncbi Aberrant regulation of argininosuccinate synthetase by TNF-alpha in human epithelial ovarian cancer
    Peter W Szlosarek
    Cancer Research UK, Translational Oncology Laboratory, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Int J Cancer 121:6-11. 2007
    ....
  4. doi Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma
    Eisuke Kobayashi
    Chemotherapy Division, National Cancer Centre Research Institute, Chuo Ku, Tokyo, Japan
    Mol Cancer Ther 9:535-44. 2010
    ..We identified argininosuccinate synthetase (ASS) as a gene differentially expressed with the highest statistical significance (Welch's t test, P = 2.2 x 10(-5))...
  5. ncbi Correction of argininosuccinate synthetase (AS) deficiency in a murine model of citrullinemia with recombinant adenovirus carrying human AS cDNA
    X Ye
    Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Gene Ther 7:1777-82. 2000
    ..We have explored the use of adenoviral vectors as a treatment modality in a murine model of citrullinemia, the Ass mouse. The Ass mouse has no endogenous AS activity due to a targeted interruption of the AS gene...
  6. ncbi Mild citrullinemia in Caucasians is an allelic variant of argininosuccinate synthetase deficiency (citrullinemia type 1)
    Johannes Haberle
    Universitatsklinikum Munster, Klinik und Poliklinik für Kinderheilkunde, Albert Schweitzer Strasse 33, D 48149 Munster, Germany
    Mol Genet Metab 80:302-6. 2003
    Citrullinemia is caused by either deficiency of argininosuccinate synthetase (ASS, citrullinemia type 1) or a defect of the SLC25A13 gene encoding a mitochondrial aspartate-glutamate transporter (citrullinemia type II)...
  7. pmc Slc25a13-knockout mice harbor metabolic deficits but fail to display hallmarks of adult-onset type II citrullinemia
    David S Sinasac
    Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Mol Cell Biol 24:527-36. 2004
    ..The absence of citrin leads to a liver-specific, quantitative decrease of argininosuccinate synthetase (ASS), causing hyperammonemia and citrullinemia...
  8. ncbi Identification of two novel mutations in the SLC25A13 gene and detection of seven mutations in 102 patients with adult-onset type II citrullinemia
    T Yasuda
    Department of Biochemistry, Faculty of Medicine, Kagoshima University, Japan
    Hum Genet 107:537-45. 2000
    ..type II citrullinemia (CTLN2) is characterized by a liver-specific deficiency of argininosuccinate synthetase (ASS) protein. We have recently identified the gene responsible for CTLN2, viz...
  9. ncbi [Adult-onset citrullinemia]
    Shu Ichi Ikeda
    Department of Internal Medicine Neurology and Rheumatology, Shinshu University School of Medicine, Matsumoto, Japan
    Brain Nerve 59:59-66. 2007
    ..of citrulline and ammonia in the plasma, which is ascribed to a deficiency of argininosuccinate synthetase (ASS), one of the urea cycle enzymes mainly located in the liver...
  10. ncbi Genomic structure of the adult-onset type II citrullinemia gene, SLC25A13, and cloning and expression of its mouse homologue
    D S Sinasac
    Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Genomics 62:289-92. 1999
    Citrullinemia is an autosomal recessive disease characterized by an argininosuccinate synthetase (ASS) deficiency...
  11. ncbi Pregnancy in a healthy woman with untreated citrullinemia
    Murray A Potter
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Med Genet A 129:77-82. 2004
    ..on a second successful pregnancy in a woman with citrullinemia due to argininosuccinate synthetase deficiency (CTLN1)...
  12. ncbi Mutation analysis of Korean patients with citrullinemia
    K M Hong
    Department of Biochemistry, Wonkwang University College of Medicine, Iksan, Korea
    Mol Cells 10:465-8. 2000
    Citrullinemia is an autosomal recessive disease due to the mutations in the argininosuccinate synthetase (ASS) gene. Mutation analysis was performed on three Korean patients with citrullinemia...
  13. ncbi Role of the L-citrulline/L-arginine cycle in iNANC nerve-mediated nitric oxide production and airway smooth muscle relaxation in allergic asthma
    Harm Maarsingh
    Department of Molecular Pharmacology, University Centre for Pharmacy, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Eur J Pharmacol 546:171-6. 2006
    ..In NO-producing cells, L-citrulline can be recycled to L-arginine in a two-step reaction involving argininosuccinate synthase (ASS) and -lyase (ASL)...
  14. ncbi Almost all about citrulline in mammals
    E Curis
    Laboratoire de Biomathématiques, E A 2498, Faculte de Pharmacie, Universite Rene Descartes, Paris, France
    Amino Acids 29:177-205. 2005
    ..synthase (NOS) and ornithine carbamoyltransferase (OCT) which produce citrulline, and argininosuccinate synthetase (ASS) that converts it into argininosuccinate...
  15. doi Assessment of the potential for displacement interactions with sugammadex: a pharmacokinetic-pharmacodynamic modelling approach
    Alex Zwiers
    Schering Plough Research Institute, a Division of MSD, Newhouse, Scotland, UK
    Clin Drug Investig 31:101-11. 2011
    ..Cyclodextrins are known to form inclusion complexes with other compounds...
  16. ncbi The evolution of aging: a new approach to an old problem of biology
    J T Bowles
    Med Hypotheses 51:179-221. 1998
    ..This advantage of aging led to the evolution of aging systems (ASs). Periodic predation was the most prevalent episodic selection pressure in evolution...
  17. ncbi Effects of acute ammonia toxicity on nitric oxide (NO), citrulline-NO cycle enzymes, arginase and related metabolites in different regions of rat brain
    M Swamy
    Department of Chemical Pathology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
    Neurosci Res 53:116-22. 2005
    ..by-product of the NOS reaction, can be recycled to arginine by successive actions of argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) via the citrulline-NO cycle...
  18. ncbi Argininosuccinate synthetase and argininosuccinate lyase: two ornithine cycle enzymes from Agaricus bisporus
    Matthijs J M Wagemaker
    Department of Microbiology, IWWR, Radboud University Nijmegen, Toernooiveld 1, NL 6525 ED Nijmegen, The Netherlands
    Mycol Res 111:493-502. 2007
    ..Argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) are two ornithine cycle enzymes catalysing the last two steps in the arginine ..
  19. ncbi Alterations in glomerular anionic sites in canine anti-glomerular basement membrane nephritis with onset of severe proteinuria
    J Sugimoto
    Mitsubishi Kasei Corporation, Research Center, School of Veterinary Medicine, Azabu University, Yokohama, Japan
    Toxicol Pathol 22:316-23. 1994
    ..Alterations of anionic sites (ASs) of glomerular basement membrane (GBM) in peripheral, proximal, and paramesangial portions were studied ..
  20. doi Brain nitric oxide production by a proline-rich decapeptide from Bothrops jararaca venom improves baroreflex sensitivity of spontaneously hypertensive rats
    Claudiana Lameu
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Hypertens Res 33:1283-8. 2010
    ..of nitric oxide (NO), which is synthesized by NO synthase (NOS) in the citrulline-NO cycle (with argininosuccinate synthase (ASS) activity being the rate-limiting step), contributes to impaired baroreflex...
  21. doi Evaluation of endogenous nitric oxide synthesis in congenital urea cycle enzyme defects
    Hironori Nagasaka
    Division of Metabolism, Chiba Children s Hospital, Chiba 266 0007, Japan
    Metabolism 58:278-82. 2009
    ..NOS reaction, can be recycled to arginine by the 2 enzymes acting in the urea cycle: argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL)...
  22. ncbi [Effects of high sodium intake on ventricular remodeling in mice]
    P V Ennezat
    INSERM U400,
    Arch Mal Coeur Vaiss 91:935-9. 1998
    ..6%: 0.64 +/- 0.01, 2%: 0.62 +/- 0.08 and 4%: 0.67 +/- 0.03 mm respectively) but LV septal wall thickness ass increased in a salt diet dependent manner (0.6%: 0.63 +/- 0.01, 2%: 0.75 +/- 0.01, 4%: 0.80 +/- 0.02 mm, p < 0...
  23. ncbi Cosegregation of open-angle glaucoma and the nail-patella syndrome
    P R Lichter
    Department of Ophthalmology, University of Michigan, Ann Arbor 48105, USA
    Am J Ophthalmol 124:506-15. 1997
    ..To evaluate two families ascertained only for the presence of glaucoma in which both nail-patella syndrome and glaucoma occur in several generations and to determine whether the two diseases are genetically related...
  24. ncbi Identification and preliminary validation of novel biomarkers of acute hepatic ischaemia/reperfusion injury using dual-platform proteomic/degradomic approaches
    S I Svetlov
    Laboratory of Molecular and Cellular Mechanisims of Injury, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Biomarkers 11:355-69. 2006
    ..liquid chromatography-tandem mass-spectrometry, we identified several hepatic proteins, including argininosuccinate synthase (ASS) and estrogen sulfotransferase (EST-1), which were degraded in the liver and rapidly released into ..
  25. ncbi Activated microglia cells express argininosuccinate synthetase and argininosuccinate lyase in the rat brain after transient ischemia
    Elisa Bizzoco
    Department of Anatomy, Histology and Forensic Medicine, Section of Histology, University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy
    Exp Neurol 208:100-9. 2007
    Argininosuccinate-synthetase (ASS), argininosuccinate-lyase (ASL) and nitric oxide synthase (NOS) act in the l-arginine-NO-l-citrulline cycle...
  26. pmc Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase
    Tawnya L Bowles
    Department of Surgery, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Int J Cancer 123:1950-5. 2008
    ..the non-essential amino acid arginine from aspartate and citrulline using the enzyme argininosuccinate synthetase (ASS)...
  27. doi Genetic variation in the urea cycle: a model resource for investigating key candidate genes for common diseases
    Sabrina Mitchell
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Hum Mutat 30:56-60. 2009
    ..cycle: carbamoyl-phosphate synthetase 1 (CPS1), ornithine transcarbamylase (OTC), argininosuccinate synthetase (ASS1), argininosuccinate lyase (ASL), and arginase 1 (ARG1)...
  28. doi Effects of crowding on ornithine-urea cycle enzyme mRNA expression and activity in gulf toadfish (Opsanus beta)
    Tammy Laberge
    Division of Marine Biology and Fisheries, Rosenstiel School of Marine and Atmospheric Science, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149, USA
    J Exp Biol 212:2394-402. 2009
    ..Quantitative PCR was utilized to determine liver GS, CPS, OCT, ARG, argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) mRNA expression...
  29. ncbi Long-chain fatty acids suppress the induction of urea cycle enzyme genes by glucocorticoid action
    M Tomomura
    Department of Biochemistry, Faculty of Medicine, Kagoshima University, Sakuragaoka, Japan
    FEBS Lett 399:310-2. 1996
    ..effects of fatty acids on urea cycle enzyme, carbamoylphosphate synthetase (CPS) and argininosuccinate synthetase (ASS), mRNA levels were examined in rat primary cultured hepatocytes...
  30. ncbi NADPH-diaphorase and cytosolic urea cycle enzymes in the rat spinal cord
    H Nakamura
    Department of Anatomy, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    J Comp Neurol 385:616-26. 1997
    Nitric oxide synthase (NOS), argininosuccinate synthetase (ASS), and argininosuccinate lyase (ASL) compose a cyclic pathway to form nitric oxide (NO). These enzymes, however, are localized differentially in most regions of the brain...
  31. pmc In vivo renal arginine release is impaired throughout development of chronic kidney disease
    Gin Fu Chen
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida 32610, USA
    Am J Physiol Renal Physiol 298:F95-102. 2010
    The kidney is a major site of arginine synthesis where citrulline is converted to arginine via argininosuccinate synthase (ASS) and lyase (ASL)...
  32. ncbi Citrulline-argininosuccinate-arginine cycle coupled to Ca2+-signaling in rat pancreatic beta-cells
    M Nakata
    Department of Laboratory Medicine, Faculty of Medicine, Kagoshima University, Japan
    Biochem Biophys Res Commun 235:619-24. 1997
    ..The enzymes involved in citrulline-arginine metabolism, argininosuccinate synthetase (ASS), argininosuccinate lyase (ASL), and NOS were expressed in rat islets and insulinoma HIT T15 cells...
  33. doi Activated microglia modulate astroglial enzymes involved in oxidative and inflammatory stress and increase the resistance of astrocytes to oxidative stress in vitro
    Claudia Röhl
    Department of Anatomy, University of Kiel, Olshausenstr 40, D 24098 Kiel, Germany
    Glia 56:1114-26. 2008
    ..dismutases (Sod), peroxiredoxins, glutathione S-transferases (Gst), nucleoside diphosphate kinase B, argininosuccinate synthase (Ass), and cellular retinol-binding protein I (Rbp1)...
  34. ncbi Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion
    Paul Ning Man Cheng
    Cancer Drug R and D Centre and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
    Cancer Res 67:309-17. 2007
    ..HCC) is believed to be auxotrophic for arginine through the lack of expression of argininosuccinate synthetase (ASS)...
  35. doi Induction of arginosuccinate synthetase (ASS) expression affects the antiproliferative activity of arginine deiminase (ADI) in melanoma cells
    Antonella Manca
    Institute of Biomolecular Chemistry, National Research Council, Traversa La Crucca, 07100 Sassari, Italy
    Oncol Rep 25:1495-502. 2011
    ..of arginine is mainly dependent on activity of ornithine transcarbamylase (OTC) and argininosuccinate synthetase (ASS) enzymes. We evaluated the effect of ADI treatment on OTC and ASS expression in a series of melanoma cell lines...
  36. ncbi Alterations in glomerular anionic sites in the autologous phase of canine anti-glomerular basement membrane nephritis
    J Sugimoto
    Mitsubishi Chemical Corporation, Yokohama Research Center, Japan
    Toxicol Pathol 24:627-35. 1996
    ..An alteration of anionic sites (ASs) of GBM was studied quantitatively using polyethyleneimine as a cationic probe by electron microscopy at weeks 1, 2,..
  37. doi Citrin deficiency, a perplexing global disorder
    David Dimmock
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM225, Houston, TX 77030, USA
    Mol Genet Metab 96:44-9. 2009
    ..A key diagnostic feature has been the deficient argininosuccinate synthetase (ASS) activity (E.C. 6.3.4.5) in liver, with normal activity in skin fibroblasts...
  38. pmc Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis
    Randie H Kim
    Department of Biological Chemistry, Division of Surgical Oncology, Center for Biophotonics and Science Technology, University of California at Davis, Sacramento, California 95817, USA
    Cancer Res 69:700-8. 2009
    ..The efficacy of ADI-PEG20 is directly correlated with argininosuccinate synthetase (ASS) deficiency...
  39. pmc Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes
    Macus Tien Kuo
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Oncotarget 1:246-51. 2010
    ..carcinoma (HCC) are auxotrophic for arginine (Arg), because they do not express argininosuccinate synthetase (ASS), the rate-limiting enzyme for the biosynthesis of arginine from citrulline...
  40. ncbi Assignment of the structural gene for argininosuccinate synthetase to proximal mouse chromosome 2
    M J Jackson
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030
    Genomics 6:545-7. 1990
    In order to develop linkage markers for the murine argininosuccinate synthetase locus (Ass-1), we have searched for restriction fragment length polymorphisms in the mouse genome using cloned sequences from the mouse arginosuccinate ..
  41. ncbi Inducible nitric oxide synthase and argininosuccinate synthetase: co-induction in brain tissue of patients with Alzheimer's dementia and following stimulation with beta-amyloid 1-42 in vitro
    Jürgen Haas
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Neurosci Lett 322:121-5. 2002
    ..levels of inducible nitric oxide synthase (iNOS) and the arginine regenerating enzyme argininosuccinate synthetase (ASS) within cortices of AD patients suggesting high output NO production...
  42. doi Analysis of gene expression identifies differentially expressed genes and pathways associated with lymphatic dissemination in patients with adenocarcinoma of the esophagus
    S M Lagarde
    Department of Surgery, Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands
    Ann Surg Oncol 15:3459-70. 2008
    ..The aim of this study was to discover a prognostic gene expression profile for lymphatic dissemination in EA and to identify genes and pathways that provide oncological insight in lymphatic dissemination...
  43. doi Transient fulminant liver failure as an initial presentation in citrullinemia type I
    Hannaneh Faghfoury
    Division of Clinical and Metabolic Genetics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
    Mol Genet Metab 102:413-7. 2011
    Citrullinemia type I (CTLN1) is a urea cycle disorder which typically presents in the neonatal period or infancy with hyperammonemia and concurrent neurologic deterioration...
  44. ncbi Genetic alterations determine chemotherapy resistance in childhood T-ALL: modelling in stage-specific cell lines and correlation with diagnostic patient samples
    David A Estes
    Department of Pathology, University of New Mexico Cancer Research and Treatment Center, Albuquerque, NM 87112, USA
    Br J Haematol 139:20-30. 2007
    ..Microarray analysis identified upregulation of asparagine synthetase (ASNS) and argininosuccinate synthase 1 (ASS1) to cell lines with acquired resistance to L-asp, and in the case of DNR, upregulation of ATP-..
  45. doi Recombinant human arginase inhibits proliferation of human hepatocellular carcinoma by inducing cell cycle arrest
    T L Lam
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
    Cancer Lett 277:91-100. 2009
    ..Expression profiling of argininosuccinate synthetase (ASS), argininosuccinate lyase (ASL) and OTC in 40 HCC tumor biopsy specimens predicted that 16 of the patients would be ..
  46. pmc The role of molecular testing and enzyme analysis in the management of hypomorphic citrullinemia
    David P Dimmock
    Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Am J Med Genet A 146:2885-90. 2008
    ..enzyme activity was not deficient in all patients with biallelic mutations suggesting this test cannot exclude the ASS1 locus in patients with mildly elevated plasma citrulline...
  47. doi Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer
    Barbara Delage
    Queen Mary University of London, Centre for Molecular Oncology and Imaging, Institute of Cancer and CR UK Clinical Centre, Barts and the London School of Medicine, Charterhouse Square, London, United Kingdom
    Int J Cancer 126:2762-72. 2010
    ..Tumoural downregulation of the enzyme argininosuccinate synthetase (ASS1), a recognised rate-limiting step in arginine synthesis, results in an intrinsic dependence on extracellular ..
  48. pmc ADI, autophagy and apoptosis: metabolic stress as a therapeutic option for prostate cancer
    Randie H Kim
    Department of Biological Chemistry, UC Davis Cancer Center, University of California Davis, 4645 2nd Avenue, Sacramento, CA 95817, USA
    Autophagy 5:567-8. 2009
    ..These cancers lose expression of an arginine synthesis enzyme, argininosuccinate synthetase (ASS), and are susceptible to arginine deprivation by arginine deiminase (ADI)...
  49. ncbi [Secondary prevention of ischemic strokes: effect of dosage of aspirin]
    J Alvarez-Sabin
    Servicio de Neurologia, Hospital General i Universitari Vall d Hebron, Barcelona, Espana
    Rev Neurol 25:541-4. 1997
    The value of acetylsalicylic acid (ASS) in the secondary prevention of ischemic stroke is well established. However, the optimum dose of AAS for stroke-threatened patients remains unsettled...
  50. ncbi The chemotherapy of rodent malaria. LXI. Drug combinations to impede the selection of drug resistance, part 4: the potential role of 8-aminoquinolines
    W Peters
    Centre for Tropical Antiprotozoal Chemotherapy, Y Block, Northwick Park Institute for Medical Research, Watford Road, Harrow HA1 3UJ, UK
    Ann Trop Med Parasitol 97:221-36. 2003
    ..chabaudi ASS (the 238C line) or P. yoelii ssp...
  51. doi Illustrated identification keys to strongylid parasites (Strongylidae: Nematoda) of horses, zebras and asses (Equidae)
    J Ralph Lichtenfels
    Animal Parasitic Diseases Laboratory, Agricultural Research Service, US Department of Agriculture, The Henry A Wallace Beltsville Agricultural Research Center, Beltsville, MD 20705 2350, USA
    Vet Parasitol 156:4-161. 2008
    The Equidae (the horse, Equus caballus, the ass, Equus asinus, zebras and their hybrids) are hosts to a great variety of nematode parasites, some of which can cause significant morbidity or mortality if individual hosts are untreated...
  52. pmc Genetic diversity in Spanish donkey breeds using microsatellite DNA markers
    J Aranguren-Mendez
    Unitat de Genètica i Millora Animal, Departament de Ciencia Animal i dels Aliments, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Genet Sel Evol 33:433-42. 2001
    ..showed little differentiation between Spanish breeds, but great differentiation between them and the Moroccan ass and also with the horse, used as an outgroup...
  53. ncbi [Is sodium salicylate suitable as a protective agent in the analgesic-induced asthma syndrome?]
    A Schäufele
    Hochgebirgsklinik Davos Wolfgang, Schweiz
    Pneumologie 44:371-2. 1990
    ..In none of the patients was the asthmatic reaction to acetylsalicylic acid (ASS) completely inhibited by the oral administration of NaS...
  54. ncbi The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein
    K Kobayashi
    Department of Biochemistry, Faculty of Medicine, Kagoshima University, Japan
    Nat Genet 22:159-63. 1999
    ..CTLN2 differs from classical citrullinaemia (CTLN1, OMIM 215700) in that CTLN1 is neonatal or infantile in onset, with ASS enzyme defects (in all tissues) arising ..
  55. ncbi Neuronal and glial coexpression of argininosuccinate synthetase and inducible nitric oxide synthase in Alzheimer disease
    M T Heneka
    Department of Neurology, University of Bonn, Germany
    J Neuropathol Exp Neurol 60:906-16. 2001
    The enzyme argininosuccinate synthetase (ASS) is the rate limiting enzyme in the metabolic pathway leading from L-citrulline to L-arginine, the physiological substrate of all isoforms of nitric oxide synthases (NOS)...
  56. ncbi Therapy of Sneddon syndrome
    Agnes Floel
    Department of Neurology, University of Munster, Munster, Germany
    Eur Neurol 48:126-32. 2002
    ..However, when we intensified antiplatelet therapy by combining clopidogrel and ASS, a slowing of disease progression, as assessed by neuropsychological testing and magnetic resonance imaging, was ..
  57. ncbi Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons
    Elisa Bizzoco
    Department of Anatomy, Histology and Forensic Medicine, Section of Histology, University of Florence, Viale G Pieraccini, 6, 50134 Florence, Italy
    Exp Neurol 204:252-9. 2007
    ..Argininosuccinate synthetase (ASS), argininosuccinate lyase (ASL) and nNOS act in the L-arginine-NO-L-citrulline cycle permitting a correct NO ..
  58. ncbi [Treatment of locally recurrent rectal cancer]
    Johan N Wiig
    Seksjon for onkologisk kirurgi, Kirurgisk klinikk, Rikshospitalet, 0027 Oslo
    Tidsskr Nor Laegeforen 127:3097-101. 2007
    It has not been common practice to operate local recurrence after rectal cancer and the treatment has received little attention in the J Norw Medical Ass.
  59. doi Real-time molecular recognition between protein and photosensitizer of photodynamic therapy by quartz crystal microbalance sensor
    Yu Yang
    Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China
    Anal Biochem 392:22-7. 2009
    ..The kinetic rate constants (k(ass) and k(diss)) and the equilibrium association constant (K(A)) for p-THPP-Hb interaction were calculated by linear ..
  60. doi The lipid composition of a cell membrane modulates the interaction of an antiparasitic peptide at the air-water interface
    Rondinelli D Herculano
    Faculdade de Ciências e Letras de Assis, Universidade Estadual Paulista, SP, Brazil
    Biochim Biophys Acta 1808:1907-12. 2011
    ..the interaction of a lipophilic glutathioine peptide known to be effective against the African Sleeping Sickness (ASS - African Trypanosomiasis) and cell membrane models represented by Langmuir monolayers...
  61. doi The syntheses, structures and properties of three new lanthanoid thioarsenates: the only example of thioarsenate acting as a ligand to a lanthanide complex
    Jian Zhou
    College of Chemistry, Chongqing Normal University, Chongqing, 401331, PR China
    Dalton Trans 42:11155-62. 2013
    Three new lanthanoid thioarsenates [Eu(en)3(η²-AsS₄)] (1, en = ethylenediamine), [Er(teta)(en)(η²-AsS₄)] (2, teta = triethylenetetramine) and [La₂(tepa)₂(μ-η¹,η³-AsS₃)₂] (3, tepa = tetraethylenepentamine) have been ..
  62. doi Occult cytomegalovirus cholangitis as a potential cause of cholestatic complications after orthotopic liver transplantation? A study of cytomegalovirus DNA in bile
    Daniel Nils Gotthardt
    Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany
    Liver Transpl 19:1142-50. 2013
    ..The anastomotic stricture (AS) group comprised patients with ASs only (n = 53). In all, 124 OLT patients underwent 240 ERC procedures...
  63. doi Antisynthetase syndrome with refractory lung involvement and myositis successfully treated with double filtration plasmapheresis
    Duygu Emine Ersozlu Bozkirli
    Department of Rheumatology, Baskent University School of Medicine, Adana, Turkey
    J Clin Apher 28:422-5. 2013
    Antisynthetase syndrome (ASS) is characterized by inflammatory muscle disease, pulmonary and joint involvement, and antisynthetase autoantibodies, with anti-Jo-1 antibody being the most common...
  64. doi The hexacarbonyldicobalt derivative of aspirin acts as a CO-releasing NSAID on malignant mesothelioma cells
    Ilaria Zanellato
    Dipartimento di Scienze e Innovazione Tecnologica DISIT, Sezione Ambiente Vita, Universita del Piemonte Orientale A Avogadro, Viale T Michel 11, 15121 Alessandria, Italy
    Metallomics 5:1604-13. 2013
    The antiproliferative activity of the aspirin derivative [2-acetoxy-(2-propynyl)benzoate]hexacarbonyldicobalt (Co-ASS) and its analogue hexacarbonyl[μ-(2-ethylphenyl)methanol]dicobalt (Co-EPM) was investigated on malignant pleural ..
  65. doi Emotion regulation predicts anxiety over a five-year interval: a cross-lagged panel analysis
    Carolin M Wirtz
    Department of Clinical Psychology and Psychotherapy, Philipps University Marburg, Marburg, Germany
    Depress Anxiety 31:87-95. 2014
    Emotion regulation (ER) deficits have been linked to symptoms of anxiety in cross-sectional studies. However, the direction of the relationship between ER and anxiety symptom severity (ASS) is unclear.
  66. doi Effective management for acidic pollution in the canal network of the Mekong Delta of Vietnam: a modeling approach
    Ngo Dang Phong
    International Rice Research Institute IRRI, Los Banos, Philippines University of Agriculture and Forestry, Ho Chi Minh City, Viet Nam Electronic address
    J Environ Manage 140:14-25. 2014
    ..pollution can cause severe environmental consequences annually in coastal areas overlain with acid sulfate soils (ASS)...
  67. ncbi Biological active ingredients of traditional Chinese herb Astragalus membranaceus on treatment of diabetes: a systematic review
    Kai Zhang
    Department of Veterinary Science, University of Messina, 98168 Messina, Italy
    Mini Rev Med Chem 15:315-29. 2015
    ..of many Chinese herbal anti-diabetic formulas, is rich in anti-diabetic compounds: polysaccharides (APS), saponins (ASS), and flavonoids (ASF) etc...
  68. doi Sorption and biodegradation of artificial sweeteners in activated sludge processes
    Ngoc Han Tran
    NUS Environmental Research Institute, National University of Singapore, T lab Building, 02 01, 5A Engineering Drive 1, Singapore 117411, Singapore Electronic address
    Bioresour Technol 197:329-38. 2015
    There is limited information on the occurrence and removal of artificial sweeteners (ASs) in biological wastewater treatment plants, and in particular, the contribution of sorption and biodegradation to their removal...
  69. pmc Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1
    Matthew Locke
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Cell Rep 16:1604-13. 2016
    b>Argininosuccinate synthase 1 (ASS1) is the rate-limiting enzyme for arginine biosynthesis. ASS1 expression is lost in a range of tumor types, including 50% of malignant pleural mesotheliomas...
  70. doi Long-Term Clinical and Histological Effects of a Bipolar Fractional Radiofrequency System in the Treatment of Facial Atrophic Acne Scars and Acne Vulgaris in Japanese Patients: A Series of Eight Cases
    Chikako Kaminaka
    1 Department of Dermatology, Wakayama Medical University, Wakayama, Japan
    Photomed Laser Surg 34:657-660. 2016
    This retrospective case series was designed to compare the long-term safety and efficacy of bipolar fractional radiofrequency (FRF) therapy as a treatment for atrophic acne scars (ASs) and acne vulgaris.
  71. doi Comparison of auditory stream segregation in sighted and early blind individuals
    Fatemeh Moghadasi Boroujeni
    Department of Audiology, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran Department of Audiology, School of Rehabilitation, Isfahan University of Medical Sciences, Isfahan, Iran
    Neurosci Lett 638:218-221. 2016
    ..of sighted and early blind individuals through spectral aspects using a psychoacoustic auditory stream segregation (ASS) test. This study was conducted on 16 sighted and 16 early blind adult individuals...
  72. doi Antisynthetase syndrome: Analysis of 11 cases
    Ester Zamarrón-de Lucas
    Servicio de Neumologia, Hospital Universitario La Paz, Instituto de Investigación Hospital Universitario La Paz IdiPAZ, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias CIBERES, Universidad Autonoma de Madrid, Madrid, España Electronic address
    Med Clin (Barc) . 2017
    Antisynthetase syndrome (ASS) is characterised by a series of clinical manifestations such as myositis, fever, mechanic's hands and diffuse interstitial lung disease (ILD), all associated with positivity to antisynthetase antibodies...
  73. ncbi The role of electrolytes and pH in RBC ASs
    J R Hess
    Blood Research Detachment, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
    Transfusion 41:1045-51. 2001
    ..The effects of variations in the electrolyte composition and volume of EASs were explored...
  74. ncbi Fixed nucleotide differences on the Y chromosome indicate clear divergence between Equus przewalskii and Equus caballus
    B Wallner
    Institut fur Tierzucht und Genetik, Veterinärmedizinische Universität Wien, Veterinärplatz, Wien, Austria
    Anim Genet 34:453-6. 2003
    ..At both positions the Przewalski's horse haplotype shows the ancestral state, in common with the members of the zebra/ass lineage. We discuss the factors that may have led to the differences in mtDNA and Y-chromosomal observations.
  75. ncbi Early cirrhosis in a patient with type I citrullinaemia (CTLN1)
    S Gucer
    Department of Pediatric Pathology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    J Inherit Metab Dis 27:541-2. 2004
    ..The patient is homozygous for a splicing mutation in intron 15 of the argininosuccinate synthase gene.
  76. ncbi Ion-association extraction of nitrophenolate ions with tetrabutylammonium ion into nonionic surfactant micelle
    Toshio Takayanagi
    Graduate School of Natural Science and Technology, Okayama University, 3 1 1 Tsushimanaka, Okayama 700 8530, Japan
    J Chromatogr A 1133:353-60. 2006
    ..Ion association constants (K(ass)) between TBA(+) and the phenolate ions, as well as binding constants of the anions to the nonionic surfactant ..
  77. ncbi [Dual platelet aggregation inhibition in coronary artery stent implantation--what is evidence-based?]
    F M Baer
    Klinik III fur Innere Medizin, Universitat zu Koln, Germany
    Dtsch Med Wochenschr 132:1275-80. 2007
    ..Additional treatment with ASS is not generally recommended since the bleeding risk of this triple medication may overweigh the benefits of dual ..
  78. ncbi Glutamine and interleukin-1beta interact at the level of Sp1 and nuclear factor-kappaB to regulate argininosuccinate synthetase gene expression
    Carole Brasse-Lagnel
    Groupe Appareil Digestif, Environnement et Nutrition, Institut Fédératif de Recherches Multidisciplinaires sur Peptides, Universite de Rouen, France
    FEBS J 274:5250-62. 2007
    We previously demonstrated that the expression of the argininosuccinate synthetase (ASS) gene, a key step in nitric oxide production, is stimulated either by interleukin-1beta[Brasse-Lagnel et al...
  79. ncbi Clopidogrel versus aspirin in patients with atherothrombosis: CAPRIE-based calculation of cost-effectiveness for Germany
    K Berger
    University Hospital Munich, Department of Hemostaseology and Transfusion Medicine, Economic Working Group, Ziemssenstrasse 1, D 80336 Munich, Germany
    Curr Med Res Opin 24:267-74. 2008
    ..model the 2-year cost-effectiveness of secondary prevention with clopidogrel versus aspirin (acetylsalicylic acid) (ASS) in German patients with myocardial infarction (MI), ischaemic stroke (IS) or diagnosed with peripheral arterial ..
  80. doi Vitamin B-sensitized photo-oxidation of dopamine
    Walter A Massad
    Departamento de Quimica, Facultad de Ciencias Exactas, Fisico Quimicas y Naturales, Universidad Nacional de Rio Cuarto, Rio Cuarto, Argentina
    Photochem Photobiol 84:1201-8. 2008
    ..Results indicate the formation of a weak dark complex Rf-DA, with a mean apparent association constant K(ass) = 30 m(-1), only detectable at DA concentrations much higher than those employed in photochemical experiments...
  81. doi Gender and age-dependent differences in the mitochondrial apoptogenic pathway in Alzheimer's disease
    Ana Lloret
    Departamento de Fisiologia, Facultad de Medicina, Avda Blasco Ibanez 15, 46010 Valencia, Spain
    Free Radic Biol Med 44:2019-25. 2008
    ..We used mitochondria isolated from brains of Wistar rats to study the toxicity of ss-amyloid peptide (Ass), and found that it increases mitochondrial peroxide production, nitration and oxidation of proteins, and release ..
  82. doi Isolation of Enterobacter sakazakii from ass' milk in Sicily: case report, safety and legal issues
    F Conte
    Dipartimento di Sanità Pubblica Veterinaria, Universita degli Studi di Messina, Polo Universitario dell Annunziata, 98168 Messina, Italy
    Travel Med Infect Dis 6:250-2. 2008
    ..Es is included between "safety criteria". The isolation of two strains of Es from 50 samples of ass' milk in Sicily is described...
  83. pmc Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production
    Juliano R Guerreiro
    Center for Applied Toxinology CAT CEPID, Instituto Butantan, SP 05503 900, Sao Paulo, Brazil
    J Biol Chem 284:20022-33. 2009
    ..for kidney cytosolic proteins with affinity for Bj-BPP-10c and demonstrate that argininosuccinate synthetase (AsS) is the major protein binding to the peptide...
  84. doi Rituximab treatment of the anti-synthetase syndrome: a retrospective case series
    Marthe Sem
    Department of Rheumatology, Rikshospitalet University Hospital, Oslo, Norway
    Rheumatology (Oxford) 48:968-71. 2009
    Interstitial lung disease (ILD) is the major determinant of morbidity and mortality in the anti-synthetase syndrome (ASS)...
  85. pmc Transvenous Treatment of a Dural Arteriovenous Fistula of the Transverse Sinus by Embolization with Platinum Coils and Onyx HD 500+
    R Siekmann
    Department of Neuroradiology, University of Giebetaen Medical Center, Giebetaen Germany
    Interv Neuroradiol 11:281-6. 2005
    ..the patient was treated for three months with 75 mg clopidogrel (Plavix(R)) and with 100 mg acetylsalicylic acid (ASS(R))...
  86. doi Whey protein-okra polysaccharide fraction blend edible films: tensile properties, water vapor permeability and oxygen permeability
    Arunya Prommakool
    Department of Food Science and Technology, Faculty of Agro Industry, Kasetsart University, Jatujak, Bangkok 10900, Thailand
    J Sci Food Agric 91:362-9. 2011
    A hot-buffer-soluble-solid fraction (HBSS) and an alkaline-soluble-solid fraction (ASS) of okra polysaccharides (OKP) were obtained using sequential extraction...
  87. doi [ASS1 mutation leading to citrullinemia I in a Chinese Han family]
    Ping Hu
    Nanjing Medical University, Nanjing, Jiangsu, People s Republic of China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 28:630-3. 2011
    To investigate potential mutation of the ASS1 gene in a male infant with acute citrullinemia type I.
  88. pmc Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice
    Tung Ming Leung
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 55:1596-609. 2012
    b>Argininosuccinate synthase (ASS) is the rate-limiting enzyme in both the urea and the L-citrulline/nitric oxide (NO·) cycles regulating protein catabolism, ammonia levels, and NO· generation...
  89. doi Rituximab therapy for refractory interstitial lung disease related to antisynthetase syndrome
    I Marie
    Department of Internal Medicine, CHU Rouen, 1 rue de Germont, 76031 Rouen Cedex, France
    Respir Med 106:581-7. 2012
    To report our experience using rituximab as therapy for refractory antisynthetase syndrome (ASS)-associated interstitial lung disease.
  90. doi Comparison of long-term outcome between anti-Jo1- and anti-PL7/PL12 positive patients with antisynthetase syndrome
    I Marie
    Department of Internal Medicine, CHU Rouen, and INSERM U 905, University of Rouen IFRMP, Institute for Biochemical Research, Rouen, France
    Autoimmun Rev 11:739-45. 2012
    The aims of the present study were to: compare the characteristics between antisynthetase syndrome (ASS) patients with anti-Jo1 antibody and those with anti-PL7/PL12 antibody...
  91. ncbi Cytokine levels as potential biomarkers for predicting the development of posttraumatic stress symptoms in casualties of accidents
    Miri Cohen
    Western Galilee Hospital, Israel
    Int J Psychiatry Med 42:117-31. 2011
    Traumatic injuries are usually associated with increased secretion of pro-inflammatory cytokines, and are sometimes followed by the development of acute stress symptoms (ASS) and posttraumatic stress symptoms (PTSS).
  92. doi Atomic clusters and atomic surfaces in icosahedral quasicrystals
    Marianne Quiquandon
    LEM UMR 104, CNRS ONERA, 29 Avenue de la Division Leclerc, F 92322 Châtillon cedex, France
    Acta Crystallogr A Found Adv 70:229-38. 2014
    ..This is due to the fact that the atomic surfaces (ASs) used to describe all known icosahedral phases are located on high-symmetry special points in six-dimensional space...
  93. doi Seronegative polyarthritis revealing antisynthetase syndrome: a multicentre study of 40 patients
    Guillaume Lefevre
    Service de Medecine Interne, Unité d Immunologie Clinique, Centre de Référence pour les Maladies Auto Immunes et Systémiques Rares, Hopital Claude Huriez, CHRU de Lille, Universite Lille Nord de France, Laboratoire d Immunologie, EA 2686, IMPRT IFR 114, CHRU de Lille, Faculté de Médecine H Warembourg, Universite Lille Nord de France, Lille, Service de Rhumatologie, Centre de Référence Maladies Systémiques Rares, CHU Hautepierre, Strasbourg, Service de Rhumatologie, Hopital Pellegrin, CHU de Bordeaux, Bordeaux, Service de Rhumatologie, CHU Fort de France, La Meynard, Fort de France, Service de Rhumatologie, CHU de Rouen, Hôpitaux de Rouen, Rouen, Service de Rhumatologie, CHU Clermont Ferrand, Clermont Ferrand, Service de Medecine Interne, Maladies Infectieuses et Tropicales, Hematologie, CH Bretagne Atlantique, Vannes Auray, Vannes, Service de Medecine Interne, Spain
    Rheumatology (Oxford) 54:927-32. 2015
    The aim of this study was to determine the frequency and characteristics of antisynthetase syndrome (ASS) revealed by polyarthritis.
  94. doi Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells
    Oula Khoury
    Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut, 1102 2801, Lebanon
    J Neurooncol 122:75-85. 2015
    ..The ability of L-citrulline to rescue cells was dependent on the expression of argininosuccinate synthetase-1 (ASS1) with the cells that were not rescued by L-citrulline being negative for ASS1 expression...
  95. pmc Differential integrative omic analysis for mechanism insights and biomarker discovery of abnormal Savda syndrome and its unique Munziq prescription
    Xia Guo
    Shenzhen Hospital of Southern Medical University, Shenzhen 518110, PR China
    Sci Rep 6:27831. 2016
    ..In terms of Traditional Uighur Medicine (TUM) Hilit (body fluid) theory, abnormal Savda syndrome (ASS) formed by abnormal Hilit is the common phenotype of complex diseases and in particular tumours...
  96. doi Severe respiratory failure as a presenting feature of an interstitial lung disease associated with anti-synthetase syndrome (ASS)
    Ines Maria Grazia Piroddi
    Respiratory Diseases Unit ASL4 Chiavarese, via Terzi 43, 16039 Sestri Levante, Italy
    Respir Investig 54:284-8. 2016
    Anti-synthetase syndrome (ASS) is defined as a heterogeneous connective tissue disorder characterized by the association of an interstitial lung disease (ILD) with or without inflammatory myositis with the presence of anti-aminoacyl-tRNA-..
  97. doi Bacterial toxins activation of abbreviated urea cycle in porcine cerebral vascular smooth muscle cells
    Rajesh G Mishra
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, USA
    Vascul Pharmacol 87:110-120. 2016
    ..This cycle indicates that argininosuccinate synthase (ASS) catalyzes l-citrulline (l-cit) conversion to form argininosuccinate (AS), and subsequent AS ..
  98. pmc Reduced argininosuccinate synthetase expression in refractory sarcomas: Impacts on therapeutic potential and drug resistance
    Youngji Kim
    Division of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo, Japan
    Oncotarget 7:70832-70844. 2016
    Treating drug-resistant sarcomas remains a major challenge. The present study aimed to identify a novel therapy for drug-resistant sarcomas based on metabolic errors involving argininosuccinate synthetase1 (ASS1).
  99. ncbi Generation of a mouse model for citrullinemia by targeted disruption of the argininosuccinate synthetase gene
    G Patejunas
    Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030
    Somat Cell Mol Genet 20:55-60. 1994
    Argininosuccinate synthetase (ASS) is a urea cycle enzyme that forms argininosuccinate from citrulline and aspartate. Mutations at the ASS locus in man cause the inherited disease, citrullinemia...
  100. ncbi The effects of phosphate, pH, and AS volume on RBCs stored in saline-adenine-glucose-mannitol solutions
    J R Hess
    Blood Research Detachment, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
    Transfusion 40:1000-6. 2000
    ..RBC ATP concentrations are the most important correlate of RBC viability. Tests were performed to determine whether increased AS volume, pH, and phosphate content increased stored RBC ATP concentrations...
  101. ncbi Novel compound heterozygous mutations for lipoprotein lipase deficiency. A G-to-T transversion at the first position of exon 5 causing G154V missense mutation and a 5' splice site mutation of intron 8
    Y Ikeda
    Departments of Etiology and Pathophysiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    J Lipid Res 42:1072-81. 2001
    ..consisting of a G-to-T transversion at the first nucleotide of exon 5 [+1 position of 3' acceptor splice site (3'-ass) of intron 4] and a T-to-C transition in the invariant GT at position +2 of the 5' donor splice site (5'-dss) of ..

Research Grants61

  1. Arginine Deprivation: A targeted therapy for Melanoma
    Lynn Feun; Fiscal Year: 2006
    ..is primarily due to the fact that melanoma cells, unlike normal cells, do not express argininosuccinate synthetase (ASS) and hence are unable to synthesize arginine...
  2. Biomarker for liver ischemia/reperfusion-induced injury
    MONIKA OLI; Fiscal Year: 2006
    ..The most promising biomarker candidate discovered to date is an enzyme of urea/nitric oxide cycle argininosuccinate synthase (ASS)...
  3. ASS, NOS2, AND ALCOHOLIC LIVER DISEASE
    Natalia Nieto; Fiscal Year: 2012
    ..We have identified argininosuccinate synthase (ASS) as up-regulated by chronic alcohol feeding...
  4. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..We identified several novel liver-specific biomarkers in rat models of hepatic injury with the argininosuccinate synthase (ASS) and hepatic estrogen sulfotransferases (EST-1) being the most sensitive markers which rapidly ..
  5. Recombinant hepatic argininosuccinate synthase (rASS) for treatment of sepsis/end
    Stanislav I Svetlov; Fiscal Year: 2012
    ..study for liver injury in response to hepatotoxins including LPS, we found that an enzyme of urea cycle, argininosuccinate synthase (ASS), is a highly sensitive marker and is released in large amounts in blood within 30 minutes after ..
  6. HEPATOCYTE GENE THERAPY FOR CITRULLINEMIA
    Brendan Lee; Fiscal Year: 2000
    ..Citrullinemia, an autosomal recessive enzymatic deficiency of argininosuccinate synthetase (ASS), is representative of the group of urea cycle defects...
  7. ROBERT JOSEPH SHMOOKLER REIS; Fiscal Year: 2016
    ..elegans models of Alzheimer's, initiated or seeded by neuron-specific tau and Ass transgenes...
  8. Molecular Basis of mu-Opioid Receptor Gene Regulation
    Jane Ko; Fiscal Year: 2009
    ..Several cis-elements have been identified, including the ds and ass cis-elements, in the proximal promoter region...
  9. Lisa Mosconi; Fiscal Year: 2014
    ..Our first aim will be to examine whether NL FHm show reduced CMRglc, increased Ass deposition and increased oxidative stress vs FH- and FHp, and whether the changes in these variables are related...
  10. WGA as a Novel Vehicle for Intranasal Delivery of an Anti-A-beta Antibody in AD
    Neelima B Chauhan; Fiscal Year: 2012
    ..Passive immunization by intravenous injection of Ass monoclonal antibodies (mAb) has shown promising results such as lowering of cerebral Ass and stabilization or ..
  11. William Z Suo; Fiscal Year: 2015
    ..GRK5 deficiency also exaggerates Ass accumulation and gliosis...
  12. Cyclohexanehexol Therapy in Transgenic Models of Alzheimer's Disease
    Alpaslan Dedeoglu; Fiscal Year: 2013
    Project Summary/Abstract Senile plaques that contain beta amyloid (Ass) and neurofibrillary tangles (NFT) with phosphorylated tau are the pathological hallmarks of Alzheimer's disease (AD)...
  13. Fyn Inhibition by AZD0530 for Alzheimers Disease
    Christopher H van Dyck; Fiscal Year: 2013
    ..Multiple studies implicate Fyn kinase in the synaptic pathophysiology of AD, with links to both Ass and Tau pathology...
  14. Neelima Chauhan; Fiscal Year: 2014
    ..However, Insulin is likely to produce hypoglycemia and elevate Ass due to its competition with insulin degrading enzyme (IDE) that degrades both insulin and Ass...
  15. Development of a HTS assay for modulators of presenilin 1 conformation
    Oksana Berezovska; Fiscal Year: 2010
    ..The final enzymatic step in generating Ass via cleavage of the amyloid precursor protein (APP) is performed by the presenilin 1 (PS1) dependent ?-secretase ..
  16. Stephen M Strittmatter; Fiscal Year: 2015
    ..The hypothesis that the Amyloid beta (Ass) peptide plays an early causative role is supported by pathology, by human genetics and by biomarker studies...
  17. The amyloid cascade in a novel mouse model of Alzheimer's disease
    Carol Anne Colton; Fiscal Year: 2013
    ..producing these pathological changes remain unknown, the amyloid cascade hypothesis states that the peptides (Ass) that make up amyloid deposits are the cause of the disease process...
  18. Charles G Glabe; Fiscal Year: 2014
    ..of amyloid deposits accumulate in disease brain and current evidence suggests that soluble, oligomeric forms of Ass may play primary role in pathogenesis...
  19. Dennis J Selkoe; Fiscal Year: 2016
    ..APP mutations or duplications cause rare but mechanistically important forms of AD, and its Ass product accumulates in all AD patients...
  20. Transmission-blocking vaccine for HIV-1
    Robert C Rose; Fiscal Year: 2010
    ..Since other amyloid fibrils (Ass) have adjuvant-like immunostimulatory properties, we will also test whether these mutated fibrils elicit the ..
  21. Testing cell autonomy of AD phenotypes using human IPS cells
    Lawrence S Goldstein; Fiscal Year: 2013
    ..the major hypothesis for AD initiation and progression is the amyloid cascade hypothesis, which proposes that Ass peptide fragments of human APP are necessary and sufficient to initiate and to drive all downstream pathologies ..
  22. Angela R Subauste; Fiscal Year: 2014
    ..At the completion of these studies we will have defined the faulty lipid signal present in obese insulin-resistant individuals. ..
  23. Pluripotent stem cell models of sporadic Alzheimer's Disease
    Lawrence S Goldstein; Fiscal Year: 2012
    ..similar to that seen in cells carrying FAD mutations or as predicted by mechanistic models of SAD such as the Ass hypothesis...
  24. Steven M Greenberg; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Deposition of ss-amyloid (Ass) in the cerebral vessels (cerebral amyloid angiopathy or CAA) is a major cause of hemorrhagic stroke, a contributor to vascular cognitive impairment, and a complicating ..
  25. Genomic Search for Susceptibility to Alzheimer Disease
    Alison M Goate; Fiscal Year: 2010
    ..early onset AD have demonstrated that mutations in three genes cause AD via a common biochemical pathway involving Ass metabolism...
  26. Uptake of STAR: Increasing Qualified Staff to improve care of older adults in Ass
    Linda Teri; Fiscal Year: 2010
    ..The proposed project is a partnership between university researchers and a community organization to translate STAR for broader, national use. ..
  27. Pathological Influence of Vasculotropic Mutant Amyloid-Beta
    William E Van Nostrand; Fiscal Year: 2011
    ..peptides in brain and develop abundant amyloid pathology or 2) low, physiological levels of human wild-type Ass peptides in brain with no amyloid pathology...
  28. DOUGLAS HAMILTON SMITH; Fiscal Year: 2016
    ..risk of developing Alzheimer's disease (AD), and TBI can induce the rapid formation of amyloid-ss (Ass) plaques, a hallmark pathology of AD...
  29. William E Van Nostrand; Fiscal Year: 2014
    Abnormal accumulation, assembly and deposition of the amyloid ss-protein (Ass) is a prominent pathological feature of patients with Alzheimer's disease (AD) and related disorders...
  30. Mouse Model of Myelin Basic Protein-Amyloid Beta Interactions in Brain
    William E Van Nostrand; Fiscal Year: 2013
    Accumulation of the amyloid ss-protein (Ass) in brain, either as parenchymal plaques or cerebrovascular deposits, is a key pathological feature of patients with Alzheimer's disease (AD) and several related disorders...
  31. Mouse Model of Myelin Basic Protein-Amyloid Beta Interactions in Brain
    William E Van Nostrand; Fiscal Year: 2012
    Accumulation of the amyloid ss-protein (Ass) in brain, either as parenchymal plaques or cerebrovascular deposits, is a key pathological feature of patients with Alzheimer's disease (AD) and several related disorders...
  32. Keith A Johnson; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The deposition of amyloid-beta (Ass) deposition is thought to begin many years prior to the onset of clinical Alzheimer's disease, but until recently it was not possible to track the ..
  33. Pathologic Interactions of Amyloid Beta-Protein
    William E Van Nostrand; Fiscal Year: 2011
    Abnormal accumulation and deposition of the amyloid ss-protein (Ass), a prominent pathological feature of patients with Alzheimer's disease (AD) and related disorders, can occur from increased production but in most cases is likely ..
  34. AFFERENT MECHANISMS UNDERLYING BLADDER PAIN
    WILLIAM DEGROAT; Fiscal Year: 2009
    ..Associate Alyssa Hawranko Naoki Yoshimura " " Res. Ass. Prof. Kyu-Sung Lee " " Res. Associate Yao-Chi Chuang " " Visiting Ass. Prof. Jon Beckel " " Res...
  35. Intranasal Delivery of Peptide Drugs to the Brain
    Nazneen N Dewji; Fiscal Year: 2012
    ..The pathological hallmarks of the disease include the formation and accumulation in the brain of ss-amyloid (Ass), widely recognized to be the major neurotoxic agent in AD...
  36. IMPAIRED TUMOR IMMUNITY DURING H PYLORI INFECTION
    VICTOR REYES; Fiscal Year: 2003
    ..class II MHC expression increased in parallel with the rise of local CD4+ T cell numbers and epithelial c;ass II MHC expression during infection with H. pylori...
  37. Development of a Novel Therapeutic for Alzheimer'Disease
    MARK ANTHONY LOVELL; Fiscal Year: 2012
    ..that lacks calcium channel blocking capacity but significantly decreases Ass1-42 production by increasing levels of alpha-secretase (ADAM-10) and decreasing levels of presenilin-1 and nicastrin ..
  38. Inhibitors of Human Pal mitoyl Acyltransferase
    CHARLES DUCKER; Fiscal Year: 2005
    ..compounds that inhibit hPAT activity by screening a diverse collection of small molecules in an established ass ay and a high-throughput yeast-based assay. 2...
  39. CENTROSOME MATURATION IN VITRO
    Robert Palazzo; Fiscal Year: 2007
    Centrosomes are unique subcellular organelles involved in the organization of cytoarchitecture from yeast to man. Ass microtubule organizing centers (MTOCs), centrosomes are directly or indirectly involved in numerous fundamental cell ..
  40. Beta-cell Granule Protein Profile by Split Reporter Ass*
    Regina Kuliawat; Fiscal Year: 2005
    ..abstract_text> ..
  41. NEUROTROPHIN GENE REGULATION IN THE INNER EAR
    Neil Segil; Fiscal Year: 2000
    ..However, difficulties associated with the introduction of foreign DNA (transfection) into post-mitotic cells such ass the hair cells, support cells, and the sensory neurons of the inner ear have so far precluded a detailed analysis ..
  42. GORDON WILLIAM LAURIE; Fiscal Year: 2016
    ..from 21 different companies, and after graduation are now employed in industry (11), academia (7;including 3 Ass't Professors) or government (3). Two are completing med school...
  43. INTERNATIONAL CONFERENCE ON MEDICAL PHYSICS
    HARACIO FARACH; Fiscal Year: 1990
    ..A Round Table of the Third World Ass. of Medical Physics (TWAMP) will also be organized and held at the end of the conference.
  44. Multimedia Teacher Training For Community Building
    D Vernon; Fiscal Year: 2005
    ..packages on student knowledge of key concepts related to building a learning community as well ass student performance of skills taught in the program. Social validity of the program will also be assessed...
  45. A Novel Small molecule TNF?? inhibitor as a disease-modifying AD drug treatment.
    Marni E Harris-White; Fiscal Year: 2012
    ..Aim 2: Determine the effect of the IDT on TNF-[unreadable] levels, Ass1-40/Ass1-42 levels, microglial activation, synaptophysin and degenerating neurons in 3xTg AD mice...
  46. A first-in-class orally active anti-TNF-alpha inhibitor to treat AD
    Marni E Harris-White; Fiscal Year: 2013
    ..Determine the effect of PD2015 on indicators of neuroinflammation and AD- associated pathology including TNF-[unreadable] levels, Ass1-40/Ass1-42 levels, microglial activation, tau, phospho-tau, synaptophysin, SNAP-25 in 3xTg AD mice.
  47. Redox Regulation of Multidrug Resistance Gene Expression
    MACUS KUO; Fiscal Year: 2009
    ..We hope from these studies to learn the molecular bases of redox conditions that affect drug sensitivity through the regulation of their respective drug resistance gene expression. ..
  48. Genomic Instability and Evolution of Drug Resistance
    MACUS KUO; Fiscal Year: 2008
    ..We anticipate from these studies to gain important insights into the function of FSA in the regulation of cell growth and differentiation in normal and malignant epithelial cells. ..
  49. Targeted Prodrug Therapy of Liver Cancers
    MACUS KUO; Fiscal Year: 2005
    ....
  50. REGULATION OF MDR GENE EXPRESSION IN LIVER CANCERS
    MACUS KUO; Fiscal Year: 2004
    ..We hope from this research, which includes in vitro cell culture and in vivo animal and tumor models, to gain important molecular insights into the genetic resolution of drug resistance and hepatocarcinogenesis. ..
  51. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
    ..abstract_text> ..
  52. MOLECULAR BASIS OF BLOOD COAGULATION REGULATION
    Steven Olson; Fiscal Year: 2009
    ..This understanding is expected to facilitate the rational design of a new generation of anticoagulant and antitumor drugs for the treatment and prevention of cardiovascular diseases and cancer. ..
  53. Towards and Earlier Diagnosis of Alzheimer's Disease: Expanding the Diagnosis
    Ranjan Duara; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  54. Comparative Functional Genomics of Longevity Assurance
    Simon Melov; Fiscal Year: 2006
    ..In years four and five we will apply the functional genomic approach defined above, as well as statistical methods refined during the first three years, to the analysis of mouse RI lines with differential lifespans. ..
  55. A Beta Vaccination: Mechanisms and Therapautic Impact
    Lennart Mucke; Fiscal Year: 2005
    ..Lastly, the proposed project will shed light on the roles of microglia in the pathogenesis of AD-related neuronal deficits. These goals and perspectives are congruent with those of RFA AG-01-003. ..
  56. Structural Basis of Serpin Function and Regulation
    Steven Olson; Fiscal Year: 2009
    ..The proposed studies will utilize mutagenesis, fluorescence, NMR and X-ray crystallography and thermodynamic and kinetic approaches to characterize serpin-protease and serpin-ligand interactions. ..
  57. MITOCHONDRIAL OXIDATIVE STRESS AND NEURODEGENERATION
    Simon Melov; Fiscal Year: 2004
    ....
  58. PRESENILIN ENDOPROTEASE & GAMMA-SECRETASE ACTIVITY
    Weiming Xia; Fiscal Year: 2003
    ..abstract_text> ..
  59. Sequestration and immobilization of metal and metalloid contaminants in sediments
    PEGGY O DAY; Fiscal Year: 2009
    ..abstract_text> ..