ASPP1

Summary

Gene Symbol: ASPP1
Description: protein phosphatase 1 regulatory subunit 13B
Alias: ASPP1, p53BP2-like, p85, apoptosis-stimulating of p53 protein 1, apoptosis-stimulating protein of p53, 1, protein phosphatase 1, regulatory (inhibitor) subunit 13B
Species: human

Top Publications

  1. ncbi Src-family tyrosine kinases in activation of ERK-1 and p85/p110-phosphatidylinositol 3-kinase by G/CCKB receptors
    L Daulhac
    Groupe de Recherche de Biologie et Pathologie Digestives, INSERM U 151, CHU Rangueil, 1 avenue J Poulhes, Institut Louis Bugnard, Batiment L3, 31403 Toulouse, France
    J Biol Chem 274:20657-63. 1999
  2. ncbi ASPP proteins specifically stimulate the apoptotic function of p53
    Y Samuels-Lev
    Ludwig Institute for Cancer Research, Imperial College School of Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, United Kingdom
    Mol Cell 8:781-94. 2001
  3. doi P85, Optison microbubbles and ultrasound cooperate in mediating plasmid DNA transfection in mouse skeletal muscles in vivo
    Yun Chao Chen
    Ultrasound Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Ultrason Sonochem 18:513-9. 2011
  4. doi Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma
    Jian Zhao
    International Joint Cancer Institute and Eastern Hospital of Hepatobiliary Surgery, Second Military Medical University, Shanghai, China
    Hepatology 51:142-53. 2010
  5. ncbi Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53
    Ze Jun Liu
    Laboratory of International Cooperation, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China
    FEBS Lett 579:1587-90. 2005
  6. pmc The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1
    Yael Aylon
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genes Dev 24:2420-9. 2010
  7. pmc Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP
    Arnaud M Vigneron
    The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom
    Genes Dev 24:2430-9. 2010
  8. pmc ASPP1 and ASPP2: common activators of p53 family members
    Daniele Bergamaschi
    Ludwig Institute for Cancer Research, Imperial College School of Medicine, St Mary s Campus, London W2 1PG, United Kingdom
    Mol Cell Biol 24:1341-50. 2004
  9. ncbi Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F
    T Hershko
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Cell Death Differ 12:377-83. 2005
  10. ncbi ASPP1 and ASPP2 are new transcriptional targets of E2F
    V Fogal
    Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK
    Cell Death Differ 12:369-76. 2005

Research Grants

  1. NUTRITIONAL AND BIOCHEMICAL/GENETIC MARKERS OF CANCER
    Jing Ma; Fiscal Year: 2007
  2. Regulation and Function of hVps34 in Insulin Signaling
    Jonathan M Backer; Fiscal Year: 2010
  3. Non-apoptotic functions of caspases
    STEVEN MILES FRISCH; Fiscal Year: 2012
  4. C Ronald Kahn; Fiscal Year: 2015
  5. ANG II AND IGF-1 INTERACTION IN CARDIOVASCULAR TISSUE
    James Sowers; Fiscal Year: 2003
  6. George L King; Fiscal Year: 2016
  7. p85/p110 PI3 Kinase-Structure, function and Physiology
    Jonathan M Backer; Fiscal Year: 2013
  8. P3K, RETROVIRAL ONCOGENE AND HOMOLOG OF PI 3-KINASE
    Peter K Vogt; Fiscal Year: 2013
  9. Myocardial ischemic activation of the Akt pathway
    STEPHEN ARMSTRONG; Fiscal Year: 2007
  10. Novel Function of PI 3-Kinase in Calcium Regulation
    Ching Shih Chen; Fiscal Year: 2004

Detail Information

Publications235 found, 100 shown here

  1. ncbi Src-family tyrosine kinases in activation of ERK-1 and p85/p110-phosphatidylinositol 3-kinase by G/CCKB receptors
    L Daulhac
    Groupe de Recherche de Biologie et Pathologie Digestives, INSERM U 151, CHU Rangueil, 1 avenue J Poulhes, Institut Louis Bugnard, Batiment L3, 31403 Toulouse, France
    J Biol Chem 274:20657-63. 1999
    ..by which the G protein-coupled receptor, gastrin/CCKB, activates the extracellular-regulated kinases (ERKs) and p85/p110-phosphatidylinositol 3-kinase (PI 3-kinase) pathways...
  2. ncbi ASPP proteins specifically stimulate the apoptotic function of p53
    Y Samuels-Lev
    Ludwig Institute for Cancer Research, Imperial College School of Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, United Kingdom
    Mol Cell 8:781-94. 2001
    We identified a family of proteins termed ASPP. ASPP1 is a protein homologous to 53BP2, the C-terminal half of ASPP2. ASPP proteins interact with p53 and specifically enhance p53-induced apoptosis but not cell cycle arrest...
  3. doi P85, Optison microbubbles and ultrasound cooperate in mediating plasmid DNA transfection in mouse skeletal muscles in vivo
    Yun Chao Chen
    Ultrasound Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Ultrason Sonochem 18:513-9. 2011
    ..In the present study, we explored if the combination of P85, a pluronic block copolymer, Optison, a microbubble contrast agent and ultrasound enhances the transfection of ..
  4. doi Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma
    Jian Zhao
    International Joint Cancer Institute and Eastern Hospital of Hepatobiliary Surgery, Second Military Medical University, Shanghai, China
    Hepatology 51:142-53. 2010
    ..This study evaluated the epigenetic regulation of ASPP1 and ASPP2 in hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC) and explores the effects of down-..
  5. ncbi Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53
    Ze Jun Liu
    Laboratory of International Cooperation, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China
    FEBS Lett 579:1587-90. 2005
    The p53 protein is one of the best-known tumour suppressors. Recently discovered ASPP1 and ASPP2 are specific activators of p53...
  6. pmc The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1
    Yael Aylon
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genes Dev 24:2420-9. 2010
    ..b>ASPP1 (apoptosis-stimulating protein of p53-1) is a key mediator of the nuclear p53 apoptotic response...
  7. pmc Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP
    Arnaud M Vigneron
    The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom
    Genes Dev 24:2430-9. 2010
    ..of p53) family of proteins can function in the nucleus to modulate the transcriptional activity of p53, with ASPP1 and ASPP2 contributing to the expression of apoptotic target genes...
  8. pmc ASPP1 and ASPP2: common activators of p53 family members
    Daniele Bergamaschi
    Ludwig Institute for Cancer Research, Imperial College School of Medicine, St Mary s Campus, London W2 1PG, United Kingdom
    Mol Cell Biol 24:1341-50. 2004
    We recently showed that ASPP1 and ASPP2 stimulate the apoptotic function of p53. We show here that ASPP1 and ASPP2 also induce apoptosis independently of p53...
  9. ncbi Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F
    T Hershko
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Cell Death Differ 12:377-83. 2005
    ..We show that E2F1 upregulates the expression of four proapoptotic cofactors of p53--ASPP1, ASPP2, JMY and TP53INP1--through a direct transcriptional mechanism...
  10. ncbi ASPP1 and ASPP2 are new transcriptional targets of E2F
    V Fogal
    Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK
    Cell Death Differ 12:369-76. 2005
    ..We show here that E2F-1 binds in vivo the promoters of ASPP1 and ASPP2 genes, two activators of p53-mediated apoptosis, E2F-1, E2F-2 and E2F-3 all activate the isolated ASPP1 ..
  11. ncbi Involvement of Raf-1 kinase and protein kinase C zeta in insulin-like growth factor I-induced brown adipocyte mitogenic signaling cascades: inhibition by cyclic adenosine 3',5'-monophosphate
    A M Valverde
    , Facultad de Farmacia, Universidad Complutense, Madrid, Spain
    Endocrinology 137:3832-41. 1996
    ..5-fold, whereas the tyrosine-phosphorylated IGF-I receptor was not directly associated with the p85 subunit of the phosphatidylinositol 3-kinase...
  12. ncbi Ca(2+)-evoked serotonin secretion by parafollicular cells: roles in signal transduction of phosphatidylinositol 3'-kinase, and the gamma and zeta isoforms of protein kinase C
    K Liu
    Division of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 20:1365-73. 2000
    ..PF cells were found to express regulatory (p85) and catalytic (p110alpha and p110beta) subunits of phosphatidylinositol 3'-kinase (PI3'-kinase)...
  13. ncbi Coupling of M2 muscarinic receptors to membrane ion channels via phosphoinositide 3-kinase gamma and atypical protein kinase C
    Y X Wang
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 274:13859-64. 1999
    ..PI-3K and by injection of beta gamma binding peptides, but it was not affected by expression of dominant negative p85 cRNA...
  14. ncbi [Construction of autocatalytic caspase-3 driven by amplified human telomerase reverse transcriptase promoter and its enhanced efficacy of inducing apoptosis in human ovarian carcinoma]
    Yue Song
    Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
    Zhonghua Fu Chan Ke Za Zhi 42:617-22. 2007
    ....
  15. ncbi NF-kappaB involvement in the activation of primary adult T-cell leukemia cells and its clinical implications
    N Arima
    First Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Sakuragaoka, Japan
    Exp Hematol 27:1168-75. 1999
    ..activities in human T cells are mediated by at least four c-Rel-related DNA binding proteins - p50, p55, p75 and p85. We examined the significance of NF-kappaB induction in primary adult T cell leukemia cells and the induction ..
  16. ncbi [The efficacy of autocatalytic casapse-3 driven by human telomerase reverse transcriptase promoter on human ovarian carcinoma]
    Yue Song
    Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
    Zhonghua Yi Xue Za Zhi 87:2919-24. 2007
    ..To construct recombinant adenoviral vector expressing autocatalysis caspase-3 driven by human telomerase reverse transcriptase promoter (hTERTp), and investigate its antitumor effect on ovarian cancer in vitro and in vivo...
  17. ncbi Granulocyte-macrophage colony-stimulating factor signals for increased glucose transport via phosphatidylinositol 3-kinase- and hydrogen peroxide-dependent mechanisms
    Manya Dhar-Mascareno
    Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 278:11107-14. 2003
    ..motif in alpha GMR at residues 358-361 as a potential interaction site for the PI 3-kinase regulatory subunit, p85. Physical evidence for p85 binding to alpha GMR was obtained by co-immunoprecipitation with antibodies to alpha GMR ..
  18. ncbi Biochemical comparisons of the Saccharomyces cerevisiae Bem2 and Bem3 proteins. Delineation of a limit Cdc42 GTPase-activating protein domain
    Y Zheng
    Department of Pharmacology, Cornell University, Ithaca, New York 14853
    J Biol Chem 268:24629-34. 1993
    ..site assembly), the break point cluster region protein, the brain protein chimerin, the 85-kDa regulatory subunit (p85) of the phosphatidylinositol 3-kinase, and the ras-GAP-binding protein (p190)...
  19. ncbi Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase
    T Yamauchi
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan
    J Biol Chem 273:15719-26. 1998
    ..In addition, the major tyrosine-phosphorylated protein in anti-p85 phosphatidylinositol 3-kinase (PI3-kinase) immunoprecipitate from liver of wild-type mice was IRS-1, and IRS-2 in ..
  20. ncbi A p85 subunit-independent p110alpha PI 3-kinase colocalizes with p70 S6 kinase on actin stress fibers and regulates thrombin-stimulated stress fiber formation in swiss 3T3 cells
    S O Johanson
    John Curtin School of Medical Research, Australian National University, Canberra, 2600, Australia
    Exp Cell Res 248:223-33. 1999
    ..In contrast, PI 3-kinase p110gamma colocalized with microtubules. The PI 3-kinase p85 subunit, known to be capable of association with p110alpha, was present in a predominantly golgi-like distribution ..
  21. ncbi PI3-kinase is involved in mitogenic signaling by the oncogenic receptor tyrosine kinase Xiphophorus melanoma receptor kinase in fish melanoma
    C Wellbrock
    Biocenter Theodor Boveri Institut, University of Wurzburg, Wurzburg, Germany
    Exp Cell Res 251:340-9. 1999
    ..Constitutive binding of the p85 adapter subunit of PI3-kinase to the Xmrk receptor was detected in PSM melanoma cells...
  22. ncbi Recruitment of the tyrosine phosphatase Src homology 2 domain tyrosine phosphatase-2 to the p85 subunit of phosphatidylinositol-3 (PI-3) kinase is required for insulin-like growth factor-I-dependent PI-3 kinase activation in smooth muscle cells
    Mijin Kwon
    Division of Endocrinology, 6111 Thurston Bowles, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7170, USA
    Endocrinology 147:1458-65. 2006
    ..Similarly in cells expressing native SHP-2, IGF-I induced SHP-2 binding to p85, whereas in cells expressing SHP-2/C459S, there was no increase...
  23. ncbi Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells
    T Skorski
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 86:726-36. 1995
    ..We show that the p85 alpha subunit of PI-3 kinase associates with BCR/ABL and that transient expression of BCR/ABL in fibroblasts and ..
  24. ncbi Improvement of the oral drug absorption of topotecan through the inhibition of intestinal xenobiotic efflux transporter, breast cancer resistance protein, by excipients
    Tetsuo Yamagata
    Department of Pharmaceutics, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
    Drug Metab Dispos 35:1142-8. 2007
    ..In wild-type mice, Pluronic P85 and Tween 20, given orally 15 min before topotecan administration, increased the area under the plasma ..
  25. ncbi Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells
    H Serve
    Molecular Biology Program, Sloan Kettering Institute, New York, New York
    J Biol Chem 269:6026-30. 1994
    ..of the immediate events after binding of the kit ligand to the receptor is its association with the 85-kDa subunit (p85) of the phosphatidylinositol (PI) 3-kinase and the activation of the enzyme...
  26. pmc Evidence that phosphatidylinositol 3-kinase is involved in sperm-induced tyrosine kinase signaling in Xenopus egg fertilization
    Gunay Mammadova
    The Graduate School of Science, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
    BMC Dev Biol 9:68. 2009
    ..However, the roles of egg-associated PI 3-kinase and Akt, especially in signal transduction at fertilization, are not well understood...
  27. ncbi Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase
    S K Jain
    Tufts University School of Medicine, St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    Oncogene 14:2217-28. 1997
    ..Our experiments show that, in contrast to other cell types, the in vivo interaction of cbl with GRB2 and p85 is significantly enhanced in BCR/abl transformed BaF3 cells and that tyrosine phosphorylation of cbl leads to a ..
  28. pmc Effect of pluronic p85 on amino acid transport in bovine brain microvessel endothelial cells
    XiaoBin Zhang
    Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Neuroimmune Pharmacol 4:35-46. 2009
    A synthetic amphiphilic block copolymer Pluronic P85 (P85) was shown to be among the most potent inhibitors of Pgp efflux system in the blood-brain barrier (BBB) and capable of enhancing delivery of Pgp substrates to the brain...
  29. pmc A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex
    Fi Tjen Mu
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Australia
    Blood 111:4580-7. 2008
    ..Pull-down experiments involving glutathione S-transferase (GST)-PI3-kinase/p85-subunit and GST-14-3-3zeta indicated that both proteins interacted with contiguous GPIb alpha sequences 580 to 590/..
  30. ncbi Dynamin inhibits phosphatidylinositol 3-kinase in hematopoietic cells
    D Harrison-Findik
    Institute of Medical and Veterinary Science, Hanson Cancer Centre, Division of Molecular Pathology, Adelaide, Australia
    Biochim Biophys Acta 1538:10-9. 2001
    ..The SH3 domain of its regulatory p85 subunit stimulates the GTPase activity of dynamin in vitro...
  31. doi Downregulation of ASPP1 in gestational trophoblastic disease: correlation with hypermethylation, apoptotic activity and clinical outcome
    Victor C Y Mak
    Department of Pathology, The University of Hong Kong, Hong Kong, China
    Mod Pathol 24:522-32. 2011
    ..b>ASPP1, a member of apoptosis-stimulating proteins of p53 (ASPPs), is a proapoptotic protein that can stimulate apoptosis ..
  32. pmc Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase
    P Banerjee
    Diabetes Unit, Massachusetts General Hospital, Boston 02129
    Proc Natl Acad Sci U S A 87:8550-4. 1990
    ..most closely related in amino acid sequence (56% identity) to the amino-terminal, kinase C-like domain of the rat p85 S6 kinase (calculated molecular mass of 82,695 Da); strong similarity extends through a further 67 residues ..
  33. pmc Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase
    C Guinebault
    Institut National de la Sante et de la Recherche Medicale, Unité 326, Hopital Purpan, Toulouse, France
    J Cell Biol 129:831-42. 1995
    ..but not of PtdIns(3,4,5,)P3 is strongly correlated with the relocation to the cytoskeleton of 29% of the p85 alpha regulatory subunit of phosphoinositide 3-kinase (PtdIns 3-kinase) and is accompanied by a significant ..
  34. ncbi Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin
    R Kapeller
    Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02215, USA
    J Biol Chem 270:25985-91. 1995
    ..and Corvera, S. (1993) Mol. Cell. Biol. 13, 6052-6063). In complementary experiments we used the recombinant p85 subunit of PI 3-kinase to identify proteins that associate with phosphoinositide 3-kinase and found that ..
  35. ncbi Role of protein phosphatase 2A in calcium-dependent chloride secretion by human colonic epithelial cells
    Jimmy Y C Chow
    Division of Gastroenterology, 0063 University Center 303, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0063, USA
    Am J Physiol Cell Physiol 292:C452-9. 2007
    ..Although both EGF and carbachol cause tyrosine phosphorylation of p85 of PI 3-kinase, only EGF activates the enzyme...
  36. ncbi Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity
    J E Damen
    Terry Fox Laboratory, British Columbia Cancer Research Centre, Vancouver, Canada
    J Biol Chem 270:23402-8. 1995
    ..with the activated erythropoietin receptor (EpR), most likely through the Src homology 2 (SH2) domains within the p85 subunit of PI-3 kinase and one or more phosphorylated tyrosines within the EpR...
  37. ncbi Endogenous angiotensin II suppresses insulin signaling in vascular smooth muscle cells from spontaneously hypertensive rats
    N Fukuda
    Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo 173 8610, Japan
    J Hypertens 19:1651-8. 2001
    ..We have demonstrated that VSMC from spontaneously hypertensive rats (SHR) produce Ang II in a homogeneous culture...
  38. pmc Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Biochem J 368:875-84. 2002
    ..phosphorylation of specific binding sites that recruit Src homology 2 (SH2)-domain-containing proteins, such as the p85 subunit of phosphoinositide 3-kinase (PI 3-kinase), the tyrosine phosphatase SHP-2 and the adapter protein Grb2...
  39. ncbi The smaller isoforms of ankyrin 3 bind to the p85 subunit of phosphatidylinositol 3'-kinase and enhance platelet-derived growth factor receptor down-regulation
    Ashley Ignatiuk
    Cancer Research Unit, Health Research Division, Saskatchewan Cancer Agency, 20 Campus Drive, Saskatoon, Saskatchewan S7N 4H4, Canada
    J Biol Chem 281:5956-64. 2006
    The Src homology 2 (SH2) domains of the p85 subunit of phosphatidylinositol 3'-kinase have been shown to bind to the tyrosine-phosphorylated platelet-derived growth factor receptor (PDGFR)...
  40. ncbi [Expression of phosphatidylinositol-3 kinase in epithelial ovarian carcinoma]
    Peng Nan Zhang
    Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China
    Zhonghua Fu Chan Ke Za Zhi 42:196-200. 2007
    ....
  41. ncbi Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells
    P Kaliman
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    Mol Endocrinol 12:66-77. 1998
    ..involvement of PI 3-kinase in IGF-induced myogenesis by overexpressing in L6E9 myoblasts a dominant negative p85 PI 3-kinase-regulatory subunit (L6E9-delta p85)...
  42. ncbi Interaction of the insulin receptor beta-subunit with phosphatidylinositol 3-kinase in bovine ROS
    R V Rajala
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, 608 Stanton L Young Boulevard, Oklahoma City, OK 73104, USA
    Invest Ophthalmol Vis Sci 42:3110-7. 2001
    ..To identify the tyrosine-phosphorylated protein(s) in bovine rod outer segments (ROS) that are associated with phosphatidylinositol 3-kinase (PI3K)...
  43. ncbi Interaction of the retinal insulin receptor beta-subunit with the p85 subunit of phosphoinositide 3-kinase
    Raju V S Rajala
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Biochemistry 43:5637-50. 2004
    ..of protein-protein interaction in the yeast Saccharomyces cerevisiae to demonstrate the interaction between the p85 subunit of PI3K and the cytoplasmic region of IRbeta...
  44. doi Mhp493 (P216) is a proteolytically processed, cilium and heparin binding protein of Mycoplasma hyopneumoniae
    Jody Wilton
    NSW Department of Primary Industries, Elizabeth Macarthur Agricultural Institute, Camden, NSW 2570, Australia
    Mol Microbiol 71:566-82. 2009
    ..is cleaved between amino acids 1040 and 1089 generating surface-accessible, heparin-binding proteins P120 and P85. Antiphosphoserine antibodies recognized P85 in 2-D immunoblotting studies and TiO(2) chromatography of trypsin ..
  45. doi Palmitate affects insulin receptor phosphorylation and intracellular insulin signal in a pancreatic alpha-cell line
    Salvatore Piro
    Department of Internal Medicine, University of Catania, Catania 95122, Italy
    Endocrinology 151:4197-206. 2010
    ..and IGF-IR autophosphorylation, and insulin receptor substrate (IRS)-1, IRS-2, phosphatidylinositol kinase (PI3K) (p85 alpha), and serine-threonine protein kinase (Akt) phosphorylated (active) forms were measured...
  46. pmc SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors
    C J McGlade
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell Biol 12:991-7. 1992
    ..The p85 alpha regulatory subunit of phosphatidylinositol (PI) 3-kinase, which associates with several receptor protein-..
  47. ncbi Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism
    D Hartley
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 271:21939-43. 1996
    ..studies from our laboratory have shown that c-Cbl is the predominant tyrosine-phosphorylated protein bound to the p85 subunit of phosphatidylinositol (PI) 3-kinase on T lymphocyte and B lymphocyte activation...
  48. ncbi Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity
    H Shigematsu
    Cancer Center and First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka 812, Japan
    J Biol Chem 272:14334-40. 1997
    ..pp70 and pp100) co-immunoprecipitated with the regulatory subunit of phosphatidylinositol 3-kinase (PI3-kinase) (p85) were identified as EpoR and Vav, respectively...
  49. pmc Receptor-mediated endocytosis of albumin by kidney proximal tubule cells is regulated by phosphatidylinositide 3-kinase
    N J Brunskill
    Department of Cell Physiology and Pharmacology, Leicester University Medical School, Leicester LE1 9HN, United Kingdom
    J Clin Invest 101:2140-50. 1998
    ..Recycling rates were unaffected. We transfected OK cells with either a wild-type p85 subunit of PI 3-kinase, or a dominant negative form of the p85 subunit (Deltap85) using the LacSwitch expression ..
  50. ncbi Activation of nuclear factor of activated T cells-(NFAT) and activating protein 1 (AP-1) by oncogenic 70Z Cbl requires an intact phosphotyrosine binding domain but not Crk(L) or p85 phosphatidylinositol 3-kinase association
    J E van Leeuwen
    Cell Biology and Metabolism Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:5153-62. 1999
    ..It is rapidly tyrosine-phosphorylated and associates with Crk(L) and p85 phosphatidylinositol 3-kinase (PI3K) upon engagement of numerous receptors linked to tyrosine kinases...
  51. pmc The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol
    A D Munday
    Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Clayton 3168, Victoria, Australia
    Proc Natl Acad Sci U S A 96:3640-5. 1999
    ..We have shown previously that a phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase forms a complex with the p85 subunit of PI 3-kinase...
  52. pmc A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
    G A Rodrigues
    Department of Pharmacology and Skirball Institute, New York University Medical Center, New York, New York 10016, USA
    Mol Cell Biol 20:1448-59. 2000
    ..A mutant of Gab1 unable to bind the p85 subunit of PI-3 kinase is defective in potentiating EGFR signaling, confirming a role for PI-3 kinase as a ..
  53. ncbi Determination of division plane and organization of contractile ring in Tetrahymena
    O Numata
    Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan
    Cell Struct Funct 26:593-601. 2001
    ..In the molecular mechanism of division plane determination and contractile ring formation, Tetrahymena 85kDa protein (p85) is localized to the presumptive division plane before the formation of the contractile ring...
  54. ncbi Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase
    Kyung D Moon
    Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 280:1543-51. 2005
    ..frequently identified binding partner for catalytically active Syk identified in a yeast two-hybrid screen was the p85 regulatory subunit of phosphoinositide 3-kinase...
  55. ncbi p85 beta-PIX is required for cell motility through phosphorylations of focal adhesion kinase and p38 MAP kinase
    Jangsoon Lee
    Department of Pharmacology, College of Medicine, Konyang University, Nonsan, 320 711, Republic of Korea
    Exp Cell Res 307:315-28. 2005
    ..Here, we provide the direct evidence that p85 beta-PIX is required for cell motility of NIH-3T3 cells by LPA through FAK and p38 MAP kinase phosphorylations...
  56. pmc Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta
    Ping Yi
    Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
    World J Gastroenterol 14:876-83. 2008
    ..To investigate the effects and molecular mechanisms of berberine on improving insulin resistance induced by free fatty acids (FFAs) in 3T3-L1 adipocytes...
  57. doi Functional association of phosphoinositide-3-kinase with platelet glycoprotein Ibalpha, the major ligand-binding subunit of the glycoprotein Ib-IX-V complex
    F T Mu
    Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    J Thromb Haemost 8:324-30. 2010
    ..subunit contains binding sites for filamin (residues 561-572, critically Phe568/Trp570), 14-3-3zeta (involving phosphorylation sites Ser587/590 and Ser609), and the phosphoinositide-3-kinase (PI3-kinase) regulatory subunit, p85.
  58. pmc Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactions
    M Reedijk
    Department of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont, Canada
    EMBO J 11:1365-72. 1992
    ..The p85 alpha subunit of PI 3'-kinase contains two Src homology (SH)2 domains, which are implicated in the interactions of ..
  59. ncbi Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor
    J E Damen
    Terry Fox Laboratory, B C Cancer Research Centre, Vancouver, Canada
    Blood 81:3204-10. 1993
    ..In vitro studies suggest that the interaction between PI 3-kinase and the activated EpR is mediated by the N- and C-terminal SH2 domains of p85 and tyrosine-phosphorylated motifs on the EpR.
  60. pmc Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach
    G Panayotou
    Ludwig Institute for Cancer Research, London, United Kingdom
    Mol Cell Biol 13:3567-76. 1993
    ..The SH2 domains of the p85 subunit of the phosphatidylinositol 3-kinase as well as of other signaling molecules were expressed in bacteria as ..
  61. ncbi CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2
    H Husson
    INSERM U364, Faculte de Medecine, Nice, France
    Oncogene 14:2331-8. 1997
    ..receptor induced the sustained tyrosine phosphorylation of c-Cbl and its subsequent association with Crk-II and the p85 kDa subunit of the PI 3-kinase, while it constitutively associates with Grb2...
  62. ncbi Insulin-like growth factor-1 (IGF-1) receptor-insulin receptor substrate complexes in the uterus. Altered signaling response to estradiol in the IGF-1(m/m) mouse
    R G Richards
    Hormones and Cancer Group, Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 273:11962-9. 1998
    ..Immunoprecipitates of uterine Tyr(P) IRS-1 contained both p85, the regulatory subunit of phosphatidylinositol (PI) 3-kinase, and PI 3-kinase catalytic activity...
  63. ncbi Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role
    M Gadina
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 160:4657-61. 1998
    ..Upon IL-2 stimulation, SHP-2 was coimmunoprecipitated with Grb2 and the p85 subunit of phosphatidylinositol 3-kinase. In contrast, SHP-2 was constitutively associated with JAK1 and JAK3...
  64. ncbi Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region
    I Gout
    Ludwig Institute for Cancer Research, London W1P 8BY and the Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, United Kingdom
    J Biol Chem 273:30061-4. 1998
    ..termed p70 S6 kinase beta (p70beta), which has a highly conserved amino acid sequence compared with that of p70/p85 S6 kinase (p70alpha) within the catalytic, kinase extension, and autoinhibitory pseudosubstrate domains, was ..
  65. ncbi Engagement of Gab1 and Gab2 in erythropoietin signaling
    A Wickrema
    Section of Hematology Oncology, University of Illinois at Chicago and West Side Veterans Affairs Medical Center, Chicago, Illinois 60607, USA
    J Biol Chem 274:24469-74. 1999
    ..of erythropoietin-responsive cells and provide docking sites for the engagement of the SHP2 phosphatase and the p85 subunit of the phosphatidylinositol 3'-kinase...
  66. ncbi Stimulation of human neutrophils by chemotactic factors is associated with the activation of phosphatidylinositol 3-kinase gamma
    P H Naccache
    Centre de Recherche en Rhumatologie et Immunologie and the Department of Medicine and Physiology, Laval University, Quebec G1V 4G2, Canada
    J Biol Chem 275:23636-41. 2000
    ..Stimulation of the cells with fMet-Leu-Phe or interleukin-8 increased the PI3K activity in p110gamma, but not p85, immunoprecipitates...
  67. ncbi Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival
    M A Guthridge
    Department of Human Immunology, The Hanson Centre for Cancer Research, IMVS, Adelaide, South Australia, Australia
    Mol Cell 6:99-108. 2000
    ..This promotes the association of phospho-Ser-585 of beta(c) with 14-3-3 and the p85 subunit of PI 3-K...
  68. ncbi The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes
    Dorothy Sears Worrall
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093, USA
    Mol Endocrinol 16:378-89. 2002
    ..insulin-induced serine phosphorylation of IRS1, phosphotyrosine-mediated protein-protein interactions involving p85, IRS1, IRbeta, and phosphotyrosine-specific antibody were greatly enhanced by pretreatment of cells with BAPTA-AM...
  69. pmc Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase
    Yupeng He
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Virol 76:9207-17. 2002
    ..was not mediated by direct NS5A-Grb2 interaction but was likely dependent on direct NS5A interaction with the p85 subunit of phosphatidylinositol 3-kinase (PI3K)...
  70. ncbi Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade
    Daniela F Bertelli
    Department of Physiology and Biophysics, University of Campinas 6040 Campinas SP, Brazil
    Am J Physiol Endocrinol Metab 284:E679-87. 2003
    ..05). Moreover, denervation reduced insulin-induced association between IRS1/IRS2 and p85/phosphatidylinositol (PI) 3-kinase...
  71. ncbi Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells
    Francesco Andreozzi
    Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Italy
    Circ Res 94:1211-8. 2004
    ..event was associated with impaired IRS-1 phosphorylation at Tyr612 and Tyr632, two sites essential for engaging the p85 subunit of PI3-kinase, resulting in defective activation of PI 3-kinase, Akt, and eNOS...
  72. ncbi Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration
    Azza B el-Remessy
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Cell Sci 118:243-52. 2005
    ..High glucose- or peroxynitrite-treated cells also showed significant increases in tyrosine nitration on the p85 subunit of PI 3-kinase that blocked PI 3-kinase and Akt-1 kinase activity...
  73. pmc Phosphoinositide3-kinase regulates actin polymerization during delayed phagocytosis of Helicobacter pylori
    Lee Ann H Allen
    Department of Medicine, University of Iowa, Coralville, 52241, USA
    J Leukoc Biol 78:220-30. 2005
    ..activated class IA phosphoinositide3-kinases (PI3Ks) in macrophages, coincident with phagocytosis, and endogenous p85 and active protein kinase Balpha accumulated on forming phagosomes...
  74. ncbi Enhancement of carboplatin toxicity by Pluronic block copolymers
    Agata A Exner
    Department of Radiology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106 5056, USA
    J Control Release 106:188-97. 2005
    The objective of this study was to examine the effects of three Pluronic triblock copolymers (F127, P85, or L61) on the cytotoxicity of carboplatin to the DHB/K12/TRb rat colorectal carcinoma cell line...
  75. pmc The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
    Ji Luo
    Department of Systems Biology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Cell Biol 170:455-64. 2005
    ..The p85 regulatory subunit of PI 3-kinase is required to mediate the insulin-dependent recruitment of PI 3-kinase to the ..
  76. ncbi Activation of Epstein-Barr virus/C3d receptor (gp140, CR2, CD21) on human B lymphoma cell surface triggers Cbl tyrosine phosphorylation, its association with p85 subunit, Crk-L and Syk and its dissociation with Vav
    Séverine Lottin-Divoux
    INSERM U 672 ex U 354, Immunochimie des Régulations Cellulaires et des Interactions Virales, Bâtiment G8, Campus 1, 5 rue Henri Desbrueres, Génopole d Evry, 91030, Evry Cedex, France
    Cell Signal 18:1219-25. 2006
    ..also triggers tyrosine phosphorylation of two components, p95 and p120, both interacting with SH2 domains of the p85 subunit of PI 3-kinase...
  77. ncbi Black raspberry extracts inhibit benzo(a)pyrene diol-epoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway
    Chuanshu Huang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Cancer Res 66:581-7. 2006
    ..In addition, overexpression of the dominant negative PI-3K mutant delta p85 reduced the induction of VEGF by B(a)PDE...
  78. ncbi Negative regulation of Fc epsilonRI-mediated signaling and mast cell function by the adaptor protein LAX
    Minghua Zhu
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 281:18408-13. 2006
    ..Upon stimulation via the antigen receptors, it is tyrosine-phosphorylated and binds Grb2 and the p85 subunit of phosphatidylinositol 3-kinase...
  79. ncbi PECAM-1 modulates thrombin-induced tissue factor expression on endothelial cells
    Jenny J Zhang
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Cell Physiol 210:527-37. 2007
    ..Thrombin-mediated TF induction was dependent on Rho Kinase activity, phosphorylation of p38(MAPK) and p85 & Akt dephosphorylation...
  80. ncbi Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation
    Nandini Ghosh-Choudhury
    Department of Pathology, The University of Texas Health Science Center at San Antonio, TX 78229, USA
    J Biol Chem 282:4983-93. 2007
    ..We demonstrate that lovastatin stimulates tyrosine phosphorylation of the p85 regulatory subunit of phosphatidylinositol 3-kinase (PI3K), leading to an increase in its kinase activity in ..
  81. ncbi Involvement of cortactin and phosphotyrosine proteins in cell-cell contact formation in cultured bovine corneal endothelial cells
    Lily Kredy-Farhan
    Goldschleger Eye Research Institute and the Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Histochem Cell Biol 129:193-202. 2008
    ..Approximately 50% of cortactin isoforms p80 and p85 were associated with the Triton-insoluble fraction while phosphotyrosine proteins were in the soluble fraction...
  82. ncbi Caspase-8 interacts with the p85 subunit of phosphatidylinositol 3-kinase to regulate cell adhesion and motility
    Jamie Senft
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, USA
    Cancer Res 67:11505-9. 2007
    ..growth factor induced the phosphorylation of caspase-8 on tyrosine-380 and the interaction of caspase-8 with the p85 alpha subunit of phosphatidylinositol 3-kinase...
  83. pmc Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha
    Chuan Hsiang Huang
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cell Cycle 7:1151-6. 2008
    ..that the majority of the oncogenic mutations occur at the interfaces between p110 domains and between p110 and p85 domains...
  84. pmc Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway
    Guodong Tie
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Vasc Res 47:519-30. 2010
    ..cells (EPCs) is mediated at the level of phosphoinositide 3-kinase (PI3K), specifically by nitrosylation of the p85 subunit of PI3K, and that this action is critical in provoking oxLDL-induced EPC apoptosis...
  85. doi Interaction between reduced glutathione and PEO-PPO-PEO copolymers in aqueous solutions: studied by 1H NMR and spin-lattice relaxation
    Lianwei Jia
    State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
    J Phys Chem B 115:2228-33. 2011
    ..The dissociation constant between GSH and P85 copolymer is determined by spin-lattice relaxation measurements, which shows the binding is of low affinity and the ..
  86. pmc Bioreducible polyether-based pDNA ternary polyplexes: balancing particle stability and transfection efficiency
    Tsz Chung Lai
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin Madison, 777 Highland Avenue, Madison, WI 53705 2222, USA
    Colloids Surf B Biointerfaces 99:27-37. 2012
    Polyplex particles formed with plasmid DNA (pDNA) and Pluronic P85-block-poly{N-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} (P85-b-P[Asp(DET)]) demonstrated highly effective transfection ability compared to PEG-based block cationomer, ..
  87. doi Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells
    Mehari Endale
    College of Veterinary Medicine, Kyungpook National University, Daegu 702 701, Republic of Korea
    Immunobiology 218:1452-67. 2013
    ..Moreover, quercetin disrupted LPS-induced p85 association to TLR4/MyD88 complex and it then limited activation of IRAK1, TRAF6 and TAK1 with a subsequent ..
  88. pmc Role of PON2 in innate immune response in an acute infection model
    Asokan Devarajan
    Division of Cardiology, Department of Medicine, University of California Los Angeles, CA 90095, USA
    Mol Genet Metab 110:362-70. 2013
    ..Moreover, the nitration to phosphorylation ratio of Tyr458 in p85 protein, the regulatory subunit of PI3-kinase that has been correlated with the phagocytosis function of ..
  89. pmc Exposure to rosiglitazone, a PPAR-γ agonist, in late gestation reduces the abundance of factors regulating cardiac metabolism and cardiomyocyte size in the sheep fetus
    Shervi Lie
    Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia and
    Am J Physiol Regul Integr Comp Physiol 306:R429-37. 2014
    ..receptor substrate-1 (IRS-1), phospho-IRS-1 (Tyr-895), phosphatidylinositol 3-kinase (PI3K) regulatory subunit p85, PI3K catalytic subunit p110α, phospho-3-phosphoinositide-dependent protein kinase 1 (Ser-241), protein kinase B (..
  90. pmc Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug design
    Ping Chen
    Oncology Structural Biology, Worldwide Research and Development, Pfizer Inc, San Diego, California, 92121
    Protein Sci 23:1332-40. 2014
    ..A number of p110α crystal structures in complex with the nSH2-iSH2 fragment of p85 regulatory subunit have been reported, including a few small molecule co-crystal structures, but the utilization of ..
  91. doi 168 effect of wortmannin in in vitro maturation of bovine oocytes
    E M Mogollón-Waltero
    Grupo de Investigación en Ciencia Animal GRICA, Universidad Cooperativa de Colombia, Bucaramanga, Santander, Colombia
    Reprod Fertil Dev 27:175. 2014
    ..maturation the determination of PI3K activity of oocytes by Western blot was performed using anti-PI3K subunit P85 antibody/peroxidase...
  92. pmc PI3-kinase mutation linked to insulin and growth factor resistance in vivo
    Jonathon N Winnay
    J Clin Invest 126:1401-12. 2016
    ..Heterozygous mutations in the gene encoding the p85α regulatory subunit of PI3K (PIK3R1) have been identified in patients with SHORT syndrome - a disorder ..
  93. doi Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy
    Ziyan Fang
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, 58th Zhongshan 2nd Road, Guangzhou, Guangdong, 510080, PR China Department of Neurology, the Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, Guangdong, 510370, PR China
    Biomaterials 97:110-21. 2016
    ..To determine whether pluronic P85-coated phenytoin poly(butylcyanoacrylate) nanoparticles (P85-PHT-PBCA-NPs) target PHT to the brain, PHT-resistant ..
  94. ncbi The alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor
    H Hayashi
    Department of Enzyme Genetics, University of Tokushima, Japan
    J Biol Chem 268:7107-17. 1993
    We have shown previously that insulin stimulated the tyrosine phosphorylation of the alpha-type 85-kDa subunit (p85) of phosphatidylinositol (PI) 3-kinase in vitro and in vivo...
  95. ncbi Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK)
    T Zhu
    Institute of Molecular and Cell Biology and Defence Medical Research Institute, National University of Singapore, 30 Medical Drive, Singapore 117609, Republic of Singapore
    J Biol Chem 273:33864-75. 1998
    ..cellular hGH stimulation and form part of the multiprotein signaling complex as does tensin, paxillin, IRS-1, the p85 subunit of phosphatidylinositol 3-kinase, C3G, SHC, Grb-2, and Sos-1...
  96. ncbi Two major proteins from locust plasma are involved in coagulation and are specifically precipitated by laminarin, a beta-1,3-glucan
    B Duvic
    Laboratoire de Pathologie Comparée, URA INRA CNRS 2209, Universite de Montpellier II, France
    Insect Biochem Mol Biol 28:959-67. 1998
    ..induced the precipitation of two major proteins with molecular masses of about 260,000 (P260) and 85,000 Da (P85)...
  97. ncbi [The use of fragments of the 85- and 120-MDa plasmids of Azospirillum brasilense Sp245 to study the plasmid rearrangement in this bacterium and to search for homologous sequences in plasmids of Azospirillum brasilense Sp7]
    E I Katsy
    Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Saratov, 410015 Russia
    Genetika 38:182-9. 2002
    A spontaneous loss of the 85- (p85) and 120-MDa (p120) replicons and simultaneous generation of a plasmid of more than 300 MDa were associated with defects in synthesis of O-specific and Calcofluor-binding polysaccharides and had no ..
  98. ncbi Ruk is ubiquitinated but not degraded by the proteasome
    Frederique Verdier
    Ludwig Institute for Cancer Research, University College of London Medical School, London, UK
    Eur J Biochem 269:3402-8. 2002
    ..Furthermore, Ruk was shown to be a negative regulator of PtdIns 3-kinase activity through binding to its P85 regulatory subunit [Gout, I., Middleton, G., Adu, J., Ninkina, N. N., Drobot, L. B., Filonenko, V., Matsuka, G...
  99. ncbi Distinct phosphoinositide 3-kinases mediate mast cell degranulation in response to G-protein-coupled versus FcepsilonRI receptors
    David A Windmiller
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 278:11874-8. 2003
    Phosphoinositide (PI) 3-kinases are critical regulators of mast cell degranulation. The Class IA PI 3-kinases p85/p110beta and p85/p110delta but not p85/p110alpha are required for antigen-mediated calcium flux in RBL-2H3 cells (Smith, A...
  100. ncbi Cbl and Akt regulate CXCL8-induced and CXCR1- and CXCR2-mediated chemotaxis
    Heather C Lane
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Room 343, Harvard Medical School, 4 Blackfan Circle, Boston, MA 02115, USA
    Int Immunol 18:1315-25. 2006
    ..We further found that stimulation with CXCL8 enhanced the association of the PI3K subunit p85 with Cbl...
  101. ncbi Insulin resistance and cardiovascular risk: New insights from molecular and cellular biology
    Carmine Morisco
    Dipartimento di Medicina Clinica Scienze Cardiovascolari ed Immunologiche, Université FEDERICO II Napoli, 80131 Napoli, Italy
    Trends Cardiovasc Med 16:183-8. 2006
    ..In particular, phosphorylation of IRS-1 on serine Ser612 causes dissociation of the p85 subunit of phosphatidylinositol 3-kinase, inhibiting further signaling...

Research Grants66

  1. NUTRITIONAL AND BIOCHEMICAL/GENETIC MARKERS OF CANCER
    Jing Ma; Fiscal Year: 2007
    ..following proteins: the GH1, insulin receptor substrate (IRS)-1, IRS-2, posphatidylinositol 3'- kinase (PI3K)-p85 subunit, peroxisome proliferator-activated receptor (PPARgamma, a nuclear hormone receptor that plays a key role in ..
  2. Regulation and Function of hVps34 in Insulin Signaling
    Jonathan M Backer; Fiscal Year: 2010
    ..While the function of p85/p110 PI 3-kinases in insulin responsive cells is well documented, the Class III PI 3-kinase, hVps34, also plays an ..
  3. Non-apoptotic functions of caspases
    STEVEN MILES FRISCH; Fiscal Year: 2012
    ..the calpain-mediated cleavage of guanine nucleotide exchange factors (GEFs) for Rac and/or by regulating the p85 subunit of PI3- Kinase...
  4. C Ronald Kahn; Fiscal Year: 2015
    ..This includes differences in the activity and properties of the different regulatory (p85) and catalytic (p110) subunits of PI 3-kinase;important effects of stoichiometry between regulatory and catalytic ..
  5. ANG II AND IGF-1 INTERACTION IN CARDIOVASCULAR TISSUE
    James Sowers; Fiscal Year: 2003
    ..In order to interrupt the PI3-kinase pathway, they will transfect a dominant-negative p85 construct using adenovirus and FuGENE methodologies in VSMC and neonatal cardiomyocytes, respectively...
  6. George L King; Fiscal Year: 2016
    ..2) Identify the role of phospho-Thr86 of p85/PI3K in causing selective insulin resistance in EC and correlate the changes of phospho-Thr86/p85 with vascular ..
  7. p85/p110 PI3 Kinase-Structure, function and Physiology
    Jonathan M Backer; Fiscal Year: 2013
    ..The Class IA PI 3-kinase is a dimer containing distinct regulatory (p85) and catalytic (p110) subunits, both of which are frequently mutated in human cancer...
  8. P3K, RETROVIRAL ONCOGENE AND HOMOLOG OF PI 3-KINASE
    Peter K Vogt; Fiscal Year: 2013
    ..analysis will concentrate on the interactions between p110[unreadable] and Ras as well as p110[unreadable] and p85. These interactions are critical to the oncogenicity of p110[unreadable];they are fundamentally changed in the ..
  9. Myocardial ischemic activation of the Akt pathway
    STEPHEN ARMSTRONG; Fiscal Year: 2007
    ..bDG) assembles a complex of signaling molecules that allows an association with and activation of the p85 subunit of PI-3K, initiating Akt phosphorylation...
  10. Novel Function of PI 3-Kinase in Calcium Regulation
    Ching Shih Chen; Fiscal Year: 2004
    ..a molecular genetic approach in which Jurkat T cells are stably transfected with a dominant-negative form of the p85 regulatory subunit to suppress the activity of endogenous PI 3-kinase...
  11. CD4/CD8 P56LCK AND ASSOCIATED KINASES
    CHRISTOPHER RUDD; Fiscal Year: 2000
    ..We propose to define whether there is preferential recruitment of the p85 (alpha,beta) and p110 (alpha,beta) subunits, whether PI 3-kinase binding regulates lck activity and to define the ..
  12. Akt-regulated pathways in platelet function
    Donna S Woulfe; Fiscal Year: 2011
    ..Our preliminary studies show that arrestins form agonist-dependent complexes with p85-PI3K subunits in human platelets...
  13. Role of Integrins/ECM in Controlling IGF-I Actions
    David Robert Clemmons; Fiscal Year: 2013
    ..We will deter- mine the role of SHP-2 transfer to p85 in regulating the activation of Rac-1 and Cdc-42. The necessity of SHP...
  14. CHARLES B GOODWIN; Fiscal Year: 2014
    ..of both PI3K regulatory subunits p851 and p852, with activating PTPN11 mutants to explore the hypothesis that both p85 subunits contribute to gain-of-function mutant Shp2-mediated GM-CSF hypersensitivity...
  15. RAJU VS RAJALA; Fiscal Year: 2016
    ..Interestingly, conditional deletion of p85[unreadable], which regulates class IA PI3K, from cones resulted in an age-related cone degeneration...
  16. RGS: A Molecular Switch Regulating Irreversible ASM Growth/Contraction in Asthma
    REYNOLD ALEXANDER PANETTIERI; Fiscal Year: 2012
    ..of regulators of G-protein signaling (RGS) proteins which inactivate G proteins and co-localize with phospho-p85 (p-p85) PI3K to facilitate S6K1 activation...
  17. Farrukh Afaq; Fiscal Year: 2014
    ..found that fisetin treatment reduced melanoma cell invasion by inhibiting the protein expression of PI3K (p110a and p85) and phosphorylation of AKT at Ser473 and Thr308...
  18. ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTION
    Harvey Lodish; Fiscal Year: 2007
    ..Overexpression of wild type proteins will be assessed for p85 and p110 subunits of PI3-kinase, Akt, PKCepsilon, PKCzeta, PIP kinase, dynamin l and 2, caveolins 1, 2, and 3, and ..
  19. LILY JUNSHEN HUANG; Fiscal Year: 2016
    ..This process involves a new function of the p85 subunit of PI3K and is PI3K kinase activity-independent...
  20. The role of BRD7 in the regulation of endoplasmic reticulum and glucose homeostas
    Sang Won Park; Fiscal Year: 2013
    ..in obesity condition and that its interaction with the regulatory subunits of phosphatidyl-inositol3-kinase (PI3K), p85[unreadable] and p85[unreadable], is crucial for its function...
  21. ER Stress, Insulin Signaling and Metabolism
    Umut Ozcan; Fiscal Year: 2011
    ..Our recent findings implicate p85αand p85β, the regulatory subunits of Phosphatidyl Inositol 3-Kinase (PI3K), as obligatory ..
  22. Lewis C Cantley; Fiscal Year: 2016
    ..The second aim is to evaluate the role of the p85 subunit of Class 1a PI3Ks in BRD7 function...
  23. Molecular mechanisms of PI3K activation in non-small cell lung cancer
    Jeffrey A Engelman; Fiscal Year: 2010
    ..PI3K consists of a dimer between the regulatory subunit, p85, and the catalytic subunit, p110...
  24. Diane L Barber; Fiscal Year: 2014
    ..on how phosphoinositide 3-kinase is pH sensitive, based on our recent structural and biochemical findings that its p85 regulatory subunit is a pH sensor...
  25. Alexander V Kabanov; Fiscal Year: 2014
    ..The previous work produced a conjugate of leptin with Pluronic P85 that is centrally active, has a long half-life in blood, is enzymatically resistant, crosses the BBB by a non-..
  26. Xiao Kun Zhang; Fiscal Year: 2014
    ..Our objectives are to use integrated multidisciplinary approaches to address several issues regarding the Bcl-2/p85 interaction: 1)...
  27. A Novel Regulator of Pl-3-Kinase in Human Liver Cancer
    Marie C DeFrances; Fiscal Year: 2010
    ..PI3K is composed of a p85 regulatory subunit and a p110 catalytic subunit...
  28. Edward B Leof; Fiscal Year: 2016
    ..scaffolding function in profibrotic TGF-? signaling whereby it couples the ligand-activated type I TGF-?R to the p85 subunit of PI3K, the most upstream component regulating non-Smad pathways such as PAK2/c-Abl and Akt/mTOR;and (ii) ..
  29. A TEMPERATURE-SENSITIVE RETROVIRUS SPLICING MUTANT
    Ralph Arlinghaus; Fiscal Year: 1991
    ..5 kb viral mRNA which is translated to produce the transforming protein termed P85/gag- mos. This splicing reaction occurs readily at 28 degrees C in cells but not at 39 degrees C...
  30. PHOSPHOINOSITIDE-3 KINASE IN CARDIAC HYPERTROPHY
    Peter Kang; Fiscal Year: 2004
    ..Two known downstream targets of PI3K are the Akt (protein kinase B) and the p70/p85 ribosomal S6 kinase (S6K). However, their role in the cardiac growth in vivo has not been established...
  31. GTP BINDING PROTEINS AND INSULIN RECEPTOR SINGNALING
    CHIN SUNG; Fiscal Year: 1999
    ..stimulation of rat HTC hepatoma and other cells one or more signaling complexes form that consists of: the IR; the p85 subunit of phosphatidylinositol-3-kinase; Ras GTPase activating protein (GAP); and p62 GAP-associated protein...
  32. SHP2 and SIRP modulate erbB signals in astrocytes
    DONALD O ROURKE; Fiscal Year: 2005
    ..SHP2 also associates with the p85 regulatory subunit of P13-K in cells in which P13-K pathway activation is unimpaired...
  33. Mechanisms of Growth Factor-Estrogen Receptor Crosstalk
    Stephen Safe; Fiscal Year: 2006
    ..will also determine the biological significance of direct ERalpha interactions with Src-SH2, G proteins, the p85 regulatory subunit of PI3-K and the IGF-1 receptor...
  34. IRS-PROTEIN AND TYPE 1 INTERFERON SIGNALING
    Leonidas Platanias; Fiscal Year: 2000
    ..The best characterized member of this family, IRS-1, binds the SH2 domains of the p85 regulatory subunit of the phosphatidylinositol 3'-kinase in an IFNalpha-dependent manner, and such an association ..
  35. SIGNAL TRANSDUCTION BY THE ECK RECEPTOR TYROSINE KINASE
    Claudius Vincenz; Fiscal Year: 1999
    ..The first was the p85 subunit of PI3-kinase...
  36. SIGNAL TRANSDUCTION BY THE C-MET RECEPTOR
    Lloyd Cantley; Fiscal Year: 1999
    ..events initiated by the novel second messenger PIP3 (Specific Aim 1a), and 3) elucidating the role of the p85 and p110 subunits of the PI 3-K in morphogenesis using a series of deletional mutants of the enzyme (Specific Aim ..
  37. ENDOCYTIC REGULATION OF HEPATOCYTE GROWTH
    MARK MC NIVEN; Fiscal Year: 1999
    ..we have cloned and sequenced genes from rat liver encoding a novel dynamin (dynamin2) and a dynamin- like protein (p85-DLP)...
  38. P13K IN RADIATION RESISTANCE OF HUMAN MELANOMA CELLS
    ZE EV RONAI; Fiscal Year: 2000
    ..melanoma cells which show reduced resistance to a radiation dominant negative mutant of regulatory subunit p85 or catalytic subunit P110 of P13K...
  39. IRS2 AND B CELL HOMEOSTASIS
    Achsah Keegan; Fiscal Year: 2000
    ..This phosphorylated IRS -2 molecule co-precipitates with the p85 subunit of PI-3 kinase in both resting and activated B-cells...
  40. DESIGN AND SYNTHESIS OF POLY L PROLINE II PEPTIDE MIMICS
    JOSE MADALENGOITIA; Fiscal Year: 2002
    ..1) erbB2/erbB3 transphosphorylation; 2) erbB2/erbB3 association with the Scr homology 2 (SH2) domains of the p85 subunit of the phosphotidylinositol 3 kinase (P13K), and 3) association of the P13K Src homology 3 (SH3) domain ..
  41. Analysis of Bidirectional Signaling Mechanisms for BTLA and HVEm
    MICHELLE SANDAU; Fiscal Year: 2010
    ..Also, a conserved Grb2 site can recruit PI3K P85, which may allow for pro- survival signals. Therefore, BTLA has both positive and negative signaling potential...
  42. Influence of P-glycoprotein in treating brain tumors
    Donald Miller; Fiscal Year: 2006
    ..in the brain under normal conditions and following P-gp modulation with either polymer formulation, Pluronic P85, or the small molecule P-gp inhibitor, GF918120...
  43. PI KINASES, CANALICULAR TRANSPORTERS AND CHOLESTASIS
    IRWIN ARIAS; Fiscal Year: 2003
    ..fluorescence microscopic techniques and novel reagents and experimental models, including genetically engineered p85-/- PI 3- kinase mice, the specific trafficking of canalicular transporters and the role of PI 3-kinase and its ..
  44. The Role of CbL in AbL Signaling and Leukemia
    Hua Gu; Fiscal Year: 2006
    ..phosphorylated by c-Abl and associate with c-Abl and other signaling molecules downstream of c-Abl, such as CrkL, p85 of PI-3 kinase and Vav, upon c-Abl activation...
  45. ERYTHROCYTE PROTEIN ANTIGENS REGULATED BY IN-LU
    Marilyn Telen; Fiscal Year: 1993
    ..In addition, a second protein (p85), bearing Lutheran antigens, will also be purified...
  46. MECHANISMS OF T LYMPHOCYTE DEVELOPMENT
    Barton Haynes; Fiscal Year: 2000
    ..transgenic mice, constructed CD7 homologous recombinant (gene knockout) mice, and demonstrated association of the p85 subunit of PI-3 kinase with the cytoplasmic domain of CD7 after ligation of the CD7 extracellular domain in Jurkat ..
  47. Signaling mechanisms in oligodendrocytes
    Robin Miskimins; Fiscal Year: 2006
    ..The proposed experiments focus on the rote of the regulatory subunit of PI3 kinase, p85, in expression of the MBP gene. p85 greatly enhances MBP promoter activity...
  48. DNA POLYMERASES
    Stuart Linn; Fiscal Year: 1999
    ..antibodies to p260, the other "core" subunit, p55, and also to peptides which were shown to complex pol epsilon (p85, p70, p49) were obtained...
  49. Indentification of AKT2/aPKC Substrates in Adipocytes
    Prem Sharma; Fiscal Year: 2005
    ..pathways such as knockout of the IR, IRS-2 or AKT2, can produce diabetes, whereas, knockout of the p85 subunit of PI3K, AKT1, IRS-1 or GLUT4 does not...
  50. DOWNSTREAM ELEMENTS IN IRS 1 SIGNALING--P55PIK
    Morris White; Fiscal Year: 2000
    ..The p55/PIK is a newly discovered SH2-protein which shares characteristics with p85, a principle regulatory element linking phosphatidylinositol-3 kinase to IRS-1 and other growth factor receptors...
  51. REGULATION OF LUNG ENDOTHELIAL CONTRACTION/PERMEABILITY
    JOE GARCIA; Fiscal Year: 2002
    ..Specific Aim #1 will examine the interaction between p60src kinase, the p85 kD actin-binding protein, cortactin, and EC MLCK in the context of endothelial cell cytoskeletal rearrangement...
  52. Estrogen and Mechanisms of Cardiomyocyte Protection
    Richard Karas; Fiscal Year: 2009
    ..cardiomyocytes, E2 induces the formation of a signaling complex that contains Estrogen Receptor a, cSrc-kinase, the p85 regulatory subunit of PI3 kinase, and Striatin, a membrane-associated scaffold protein...
  53. TYROSINE PHOSPHATASES IN ENDOTHELIAL GROWTH CONTROL
    Takamune Takahashi; Fiscal Year: 2009
    ..associates with FGF receptor, and 7) CD148 cytoplasmic domain interacts with- and dephosphorylates the PI3 kinase p85 subunit and p120 catenin molecules...
  54. COSTIMULATION OF T LYMPHOCYTES OF CD28
    John Imboden; Fiscal Year: 2003
    ..Also, a 50 kD protein that binds CD28 at Tyr 170 and is closely related to phosphatidylinositol 3'-kinase p85 will be characterized...
  55. Hypothalamic Leptin and Insulin Signaling
    Jennifer Hill; Fiscal Year: 2006
    ..pattern of PI3K within the hypothalamus using double-labeled I3HH and IHC for NPY, POMC, and the PI3K subunits p85 and p110...
  56. Is Tissue ACE Required for Diabetic Renal Damage?
    Harold Franch; Fiscal Year: 2005
    ..We believe that this approach will not only critically test our hypothesis, but will also lay the ground work for future studies into the role of ACE in the diabetic kidney. ..
  57. Sensory Gating in Schizophrenia: Multiple Measures
    Julie Patterson; Fiscal Year: 2004
    ....
  58. MECHANISMS OF PROTEIN ACCUMULATION IN RENAL HYPERTROPHY
    Harold Franch; Fiscal Year: 2002
    ..It should also lay the ground work for further investigations into the mechanisms behind renal hypertrophy. ..
  59. Polymer-Nucleotide Complexes with Cytotoxic Activity
    Serguei Vinogradov; Fiscal Year: 2007
    ..Application of the drug forms may help to prevent many of the known chemotherapy side effects. Data accumulated in these studies can be directly used for design of better systemic formulations of cytotoxic nucleotide drugs. ..
  60. 10th-12th Conferences: Drug Abuse/Immunomodulation/AIDS
    Thomas Rogers; Fiscal Year: 2005
    ..The combination of the web site, and a brochure mailing should guarantee wide dissemination of information regarding the meeting, and guarantee publicity for the published results. ..
  61. Neuropeptide Signaling in Prostate Cancer
    Ruoqian Shen; Fiscal Year: 2006
    ..abstract_text> ..
  62. Erythropoietin receptor /Janus Kinase 2 complex
    Lily Huang; Fiscal Year: 2006
    ..Through this research proposal, the applicant will receive training in biophysical and structural biology and will gain the necessary skills and knowledge to become an independent investigator. ..
  63. Function of Cortactin, a Src Target
    J Parsons; Fiscal Year: 2005
    ..Such mice, bearing a mutated form of Cortactin will allow one to directly test the role of Cortactin in mediating specific cellular functions in a cell type specific fashion. ..
  64. Effects of the Angiopoietins on Tie 2 Downregulation
    Christopher Kontos; Fiscal Year: 2005
    ..abstract_text> ..
  65. PROTEIN KINASES IN YEAST DNA CHECKPOINT PATHWAYS
    David Stern; Fiscal Year: 2009
    ..Aim 3. Molecular techniques will be used for functional analysis of NFBD1/MDC1 in the activities identified in Aim 2. ..
  66. Regulation of Maternal Fuel Supply and Neonatal Adiposity
    Linda Barbour; Fiscal Year: 2008
    ..Such information may result in new treatment strategies in pregnant women to normalize fetal growth. ..