ASPM

Summary

Gene Symbol: ASPM
Description: abnormal spindle microtubule assembly
Alias: ASP, Calmbp1, MCPH5, abnormal spindle-like microcephaly-associated protein, asp (abnormal spindle) homolog, microcephaly associated
Species: human

Top Publications

  1. pmc A fifth locus for primary autosomal recessive microcephaly maps to chromosome 1q31
    L Pattison
    Molecular Medicine Unit, St James s University Hospital, Leeds, LS9 7TF, United Kingdom
    Am J Hum Genet 67:1578-80. 2000
  2. ncbi Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes
    M do Carmo Avides
    Cancer Research Campaign Cell Cycle Genetics Group, University of Cambridge, Department of Genetics, Downing Street, Cambridge, UK CB2 3EH
    Nat Cell Biol 3:421-4. 2001
  3. ncbi ASPM is a major determinant of cerebral cortical size
    Jacquelyn Bond
    Molecular Medicine Unit, University of Leeds, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Nat Genet 32:316-20. 2002
  4. pmc Protein-truncating mutations in ASPM cause variable reduction in brain size
    Jacquelyn Bond
    Molecular Medicine Unit, University of Leeds, St James s University Hospital, Leeds, United Kingdom
    Am J Hum Genet 73:1170-7. 2003
  5. pmc Evolution of the human ASPM gene, a major determinant of brain size
    Jianzhi Zhang
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genetics 165:2063-70. 2003
  6. ncbi Genetic analysis of primary microcephaly in Indian families: novel ASPM mutations
    A Kumar
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, Karnataka, India
    Clin Genet 66:341-8. 2004
  7. ncbi The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein
    Natalay Kouprina
    Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, MD 20892, USA
    Hum Mol Genet 14:2155-65. 2005
  8. ncbi The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein
    Xueyan Zhong
    Division of Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA
    Cell Cycle 4:1227-9. 2005
  9. pmc ASPM mutations identified in patients with primary microcephaly and seizures
    J Shen
    J Med Genet 42:725-9. 2005
  10. ncbi Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens
    Nitzan Mekel-Bobrov
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Science 309:1720-2. 2005

Research Grants

  1. Centrosomin and Centrosomes in Cell Division
    Timothy L Megraw; Fiscal Year: 2012
  2. Neurogenesis: Career Development Plan in the Genetic and Modeling of Microcephaly
    STEPHANIE LEE BIELAS; Fiscal Year: 2011
  3. STEPHANIE LEE BIELAS; Fiscal Year: 2015
  4. Switching Kinetics in Calmodulin-IQ Domain Complexes
    Anthony Persechini; Fiscal Year: 2009
  5. ATMOSPHERIC PROTON MICROPROBE FOR TRACE ELEMENT ANALYSIS
    RAYMOND BOISSEAU; Fiscal Year: 1992
  6. Neural Bases of Auditory Processing Disorders in Adults
    Patrick Wong; Fiscal Year: 2007
  7. Acquisition of Mandarin Tones: A Cross-Sectional Study
    Patrick Wong; Fiscal Year: 2007
  8. Evolution of vertebrate sensory genes
    Jianzhi Zhang; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications154 found, 100 shown here

  1. pmc A fifth locus for primary autosomal recessive microcephaly maps to chromosome 1q31
    L Pattison
    Molecular Medicine Unit, St James s University Hospital, Leeds, LS9 7TF, United Kingdom
    Am J Hum Genet 67:1578-80. 2000
    ..The condition is genetically heterogeneous, and four loci have already been identified. We now report a fifth locus, MCPH5, which is an 8-cM region mapping to chromosome 1q31, defined by the markers GATA135F02 and D1S1678.
  2. ncbi Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes
    M do Carmo Avides
    Cancer Research Campaign Cell Cycle Genetics Group, University of Cambridge, Department of Genetics, Downing Street, Cambridge, UK CB2 3EH
    Nat Cell Biol 3:421-4. 2001
    ..Similarities between the phenotypes of the Drosophila mutants asp and polo point towards a common role in spindle pole function...
  3. ncbi ASPM is a major determinant of cerebral cortical size
    Jacquelyn Bond
    Molecular Medicine Unit, University of Leeds, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Nat Genet 32:316-20. 2002
    ..Here we show that the most common cause of MCPH is homozygous mutation of ASPM, the human ortholog of the Drosophila melanogaster abnormal spindle gene (asp), which is essential for normal ..
  4. pmc Protein-truncating mutations in ASPM cause variable reduction in brain size
    Jacquelyn Bond
    Molecular Medicine Unit, University of Leeds, St James s University Hospital, Leeds, United Kingdom
    Am J Hum Genet 73:1170-7. 2003
    Mutations in the ASPM gene at the MCPH5 locus are expected to be the most common cause of human autosomal recessive primary microcephaly (MCPH), a condition in which there is a failure of normal fetal brain development, resulting in ..
  5. pmc Evolution of the human ASPM gene, a major determinant of brain size
    Jianzhi Zhang
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genetics 165:2063-70. 2003
    ..An evolutionary analysis of genes controlling brain development may shed light on it. ASPM (abnormal spindle-like microcephaly associated) is one of such genes, as nonsense mutations lead to primary ..
  6. ncbi Genetic analysis of primary microcephaly in Indian families: novel ASPM mutations
    A Kumar
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, Karnataka, India
    Clin Genet 66:341-8. 2004
    ..It is a genetically heterogeneous disorder with six known loci: MCPH1 to MCPH6. Only the genes for MCPH1 and MCPH5 have been identified so far. We have ascertained nine consanguineous families with primary microcephaly from India...
  7. ncbi The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein
    Natalay Kouprina
    Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, MD 20892, USA
    Hum Mol Genet 14:2155-65. 2005
    The most common cause of primary autosomal recessive microcephaly (MCPH) appears to be mutations in the ASPM gene which is involved in the regulation of neurogenesis...
  8. ncbi The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein
    Xueyan Zhong
    Division of Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA
    Cell Cycle 4:1227-9. 2005
    Homozygous mutations in the abnormal spindle-like, microcephaly-associated ASPM gene are the leading cause of autosomal recessive primary microcephaly...
  9. pmc ASPM mutations identified in patients with primary microcephaly and seizures
    J Shen
    J Med Genet 42:725-9. 2005
    ..recessive primary microcephaly (MCPH) is a heterogeneous disorder with at least six genetic loci (MCPH1-6), with MCPH5, caused by ASPM mutation, being the most common...
  10. ncbi Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens
    Nitzan Mekel-Bobrov
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Science 309:1720-2. 2005
    The gene ASPM (abnormal spindle-like microcephaly associated) is a specific regulator of brain size, and its evolution in the lineage leading to Homo sapiens was driven by strong positive selection...
  11. ncbi Normal variants of Microcephalin and ASPM do not account for brain size variability
    Roger P Woods
    Ahmanson Lovelace Brain Mapping Center, David Geffen School of Medicine, University of California, CA 90095, USA
    Hum Mol Genet 15:2025-9. 2006
    ..The genes responsible for variation in brain volume are not known. Microcephalin (MCPH1) and ASPM (abnormal spindle-like microcephaly associated) have been proposed as candidate genes as mutations in both genes ..
  12. pmc Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target
    S Horvath
    Department of Human Genetics, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 103:17402-7. 2006
    ..We identify ASPM (abnormal spindle-like microcephaly associated) as a key gene within this module and demonstrate its overexpression ..
  13. ncbi The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence
    Nitzan Mekel-Bobrov
    Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 16:600-8. 2007
    ..Two primary microcephaly genes, ASPM and Microcephalin, have been implicated not only in the adaptive evolution of the lineage leading to humans, but in ..
  14. ncbi ASPM and citron kinase co-localize to the midbody ring during cytokinesis
    Murugan Paramasivam
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, USA
    Cell Cycle 6:1605-12. 2007
    Mutations in ASPM (abnormal spindle-like microcephaly associated) and citron kinase (CITK) cause primary microcephaly in humans and rodents, respectively...
  15. ncbi Investigation of MCPH1 G37995C and ASPM A44871G polymorphisms and brain size in a healthy cohort
    C Dobson-Stone
    Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    Neuroimage 37:394-400. 2007
    Loss-of-function mutations in MCPH1 and ASPM are responsible for some cases of autosomal recessive primary microcephaly...
  16. ncbi Novel protein-truncating mutations in the ASPM gene in families with autosomal recessive primary microcephaly
    Asma Gul
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    J Neurogenet 21:153-63. 2007
    ..Homozygous mutations in the ASPM gene, located at MCPH5 locus on chromosome 1q31, are the most common cause of MCPH particularly in the Pakistani population...
  17. doi A common SNP of MCPH1 is associated with cranial volume variation in Chinese population
    Jin kai Wang
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, PR China
    Hum Mol Genet 17:1329-35. 2008
    ..MCPH1 and abnormal spindle-like MCPH associated (ASPM) are the two known MCPH causing genes that were suggested undergone recent positive selection in human populations...
  18. ncbi Expression analysis of the autosomal recessive primary microcephaly genes MCPH1 (microcephalin) and MCPH5 (ASPM, abnormal spindle-like, microcephaly associated) in human malignant gliomas
    Carsten Hagemann
    Department of Neurosurgery, University of Wurzburg, D 97080 Wurzburg, Germany
    Oncol Rep 20:301-8. 2008
    ..Microcephalin and ASPM are two of the genes causing this disease. Both are centrosomal proteins involved in cell cycle regulation...
  19. pmc The molecular landscape of ASPM mutations in primary microcephaly
    A K Nicholas
    Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK
    J Med Genet 46:249-53. 2009
    ..The condition is genetically heterogeneous with mutations in ASPM being most commonly reported.
  20. pmc Human ASPM participates in spindle organisation, spindle orientation and cytokinesis
    Julie Higgins
    Section of Ophthalmology and Neuroscience, Wellcome Trust Brenner Building, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    BMC Cell Biol 11:85. 2010
    Mutations in the Abnormal Spindle Microcephaly related gene (ASPM) are the commonest cause of autosomal recessive primary microcephaly (MCPH) a disorder characterised by a small brain and associated mental retardation...
  21. doi A gene expression signature of epithelial tubulogenesis and a role for ASPM in pancreatic tumor progression
    Wei Yu Wang
    Laboratory for Tumor Epigenetics and Stemness, National Institute of Cancer Research and Translational Center for Glandular Malignancies, National Health Research Institutes, Tainan, Taiwan Department of Pathology, National Cheng Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Gastroenterology 145:1110-20. 2013
    ..We investigated whether changes in gene expression during pancreatic epithelial morphogenesis were associated with outcomes of patients with PDAC after surgery...
  22. pmc A molecular sensor system based on genetically engineered alkaline phosphatase
    C A Brennan
    Abbott Laboratories, North Chicago, IL 60064-4000, USA
    Proc Natl Acad Sci U S A 92:5783-7. 1995
    ..Hybrid proteins were constructed by using wild-type AP and point mutants of AP [Asp-101 --> Ser (D101S) and Asp-153 --> Gly (D153G)]...
  23. ncbi [Increasing fluoroquinolone low-sensitivity in enterotoxigenic Escherichia coli isolated from diarrhea of overseas travelers in Tokyo]
    S Matsushita
    Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health
    Kansenshogaku Zasshi 75:785-91. 2001
    ..The mutations of a Ser to a Leu at position 83 (Ser-83-->Leu) was found in 19 strains, and Asp-87-->Tyr was found in 2 strains.
  24. ncbi Peptide chiral purity determination: hydrolysis in deuterated acid, derivatization with Marfey's reagent and analysis using high-performance liquid chromatography-electrospray ionization-mass spectrometry
    D R Goodlett
    Immunobiology Research Institute, Annandale, NJ 08801, USA
    J Chromatogr A 707:233-44. 1995
    ..This procedure was used to determine the chiral purity of each amino acid in a purified, hexapeptide by-product (Arg-Lys-Lys-Asp-Val-Tyr) present in a kilogram batch of the synthetic pentapeptide, thymopentin (Arg-Lys-Asp-Val-Tyr).
  25. ncbi Capillary zone electrophoresis at subzero temperatures. I. Separation of the cis and trans conformers of small peptides
    S Ma
    Department of Chemical Engineering, Yale University, New Haven, CT 06520, USA
    J Chromatogr A 716:167-82. 1995
    ..3 as measured with a glass electrode. The two conformers of Tyr-Pro-Phe-Asp-Val-Val-Gly-NH2 were baseline separated at -12 degrees C and the four conformers of Tyr-Pro-Phe-Gly-Tyr-Pro-Ser-NH2 ..
  26. ncbi Identification, purification and characterization of a putative novel growth-inhibitory and/or apoptotic protein from rat liver
    S S Dadke
    Cellular Carcinogenesis Laboratory, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay, India
    Tumori 84:14-20. 1998
    ..17 amino acids of the growth-inhibitory polypeptide showed Val-Leu-Leu-Ala-Glu-Ala-Glu-Thr-Ala-Ile-Val-Asn-Gly-Leu-Asp-Lys-Ile...
  27. doi Adaptive evolution of four microcephaly genes and the evolution of brain size in anthropoid primates
    Stephen H Montgomery
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    Mol Biol Evol 28:625-38. 2011
    ..We analyzed the molecular evolution of four genes associated with microcephaly (ASPM, CDK5RAP2, CENPJ, MCPH1) across 21 species representing all major clades of anthropoid primates...
  28. ncbi Mosquito oostatic factor: a novel decapeptide modulating trypsin-like enzyme biosynthesis in the midgut
    D Borovsky
    Institute of Food and Agricultural Sciences, University of Florida, Vero Beach 32962
    FASEB J 4:3015-20. 1990
    ..The factor is a decapeptide with a molecular mass of 1047.6. The primary sequence has been determined as NH2-Tyr-Asp-Pro-Ala-Pro-Pro-Pro-Pro-Pro-Pro-COOH from mass spectra recorded on a quadrupole Fourier transform instrument...
  29. pmc Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephaly
    Arun Kumar
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India
    Am J Hum Genet 84:286-90. 2009
    ..97 between markers D1S2797 and D1S417. Previously, mutations in four genes, MCPH1, CDK5RAP2, ASPM, and CENPJ, that code for centrosomal proteins have been shown to cause this disorder...
  30. ncbi The amino acid sequence of eukaryotic translation initiation factor 1 and its similarity to yeast initiation factor SUI1
    M A Kasperaitis
    Department of Molecular Cell Biology, University of Utrecht, The Netherlands
    FEBS Lett 365:47-50. 1995
    ..After cleavage with the endoproteinase Asp-N, three peptides were sequenced...
  31. ncbi Effects of excitatory amino acid antagonists on synaptic transmission in the ampullae of Lorenzini of the skate Raja clavata
    G N Akoev
    Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad
    J Comp Physiol A 168:647-52. 1991
    ..The L-glutamate (L-GLU) response was more resistant to the blockade than the L-aspartate (L-ASP) response. 7...
  32. doi Mutation analysis of the ASPM gene in 18 Pakistani families with autosomal recessive primary microcephaly
    Rizwana Kousar
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    J Child Neurol 25:715-20. 2010
    ..markers linked to 7 autosomal recessive primary microcephaly loci revealed linkage of 18 families to the MCPH5 locus. Sequence analysis of the ASPM gene in 18 linked families detected 2 novel nonsense mutations (c...
  33. pmc Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4
    Duane L Guernsey
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    Am J Hum Genet 87:40-51. 2010
    ..loci have been genetically mapped, and the underlying causal genes have been identified for MCPH1, MCPH3, MCPH5, MCPH6, and MCPH7 but not for MCPH2 or MCPH4. The known genes play roles in mitosis and cell division...
  34. pmc ASPM and microcephalin expression in epithelial ovarian cancer correlates with tumour grade and survival
    A Brüning-Richardson
    Section of Ophthalmology and Neurosciences, Leeds Institute of Molecular Medicine, Welcome Trust Brenner Building, St James s University Hospital, Leeds LS9 7TF, UK
    Br J Cancer 104:1602-10. 2011
    ..Two microcephaly-associated proteins, abnormal spindle-like microcephaly-associated protein (ASPM) and microcephalin, are involved in mitosis and DNA damage repair...
  35. ncbi Molecular genetic determinants of human brain size
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Biochem Biophys Res Commun 345:911-6. 2006
    ..At least four of these, microcephalin (MCPH1), abnormal spindle-like microcephaly-associated (ASPM), cyclin-dependent kinase 5 regulatory associated protein 2 (CDK5RAP2), and centromere-associated protein J (CENPJ) ..
  36. ncbi [Molecular genetics of lissencephaly and microcephaly]
    Ganeshwaran Hitoshi Mochida
    Department of Neurology, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, and Harvard Medical School, 77 Avenue Louis Pasteur, NRB 266, Boston, MA 02115, USA
    Brain Nerve 60:437-44. 2008
    ..Microcephaly vera is a form of microcephaly with four responsible genes reported to date. Three of them (ASPM, CENPJ and CDK5RAP2) localize to the mitotic centrosome, and one (MCPH1) is implicated in cell cycle checkpoint ..
  37. pmc Pharmacological characterization of the metabotropic glutamate receptor inhibiting D-[3H]-aspartate output in rat striatum
    G Lombardi
    Dipartimento di Farmacologia Preclinica e Clinica Mario Aiazzi Mancini, , Italy
    Br J Pharmacol 110:1407-12. 1993
    ..in adult rat striatal slices by measuring (i) KCl (30 mM)-induced output of previously taken up D-[3H]-aspartate (Asp), (ii) forskolin (30 microM)-induced adenosine 3':5'-cyclic monophosphate (cyclic AMP) accumulation and (iii) ..
  38. ncbi Effect of phosphoramidon (endothelin converting enzyme inhibitor) and BQ-123 (endothelin receptor subtype A antagonist) on blood pressure in hypertensive rats
    E G McMahon
    Department of Cardiovascular Diseases Research, G.D. Searle and Co, St. Louis, Missouri 63167
    Am J Hypertens 6:667-73. 1993
    ..We also determined whether the ETA receptor antagonist BQ-123 (cyclo [D-Trp-D-Asp-Pro-D-Val-Leu]) might lower MAP in hypertensive rats...
  39. pmc Cardiovascular and behavioural effects of intracerebroventricularly administered tachykinin NK3 receptor antagonists in the conscious rat
    E Cellier
    Department of Physiology, Faculty of Medicine, , , Canada
    Br J Pharmacol 122:643-54. 1997
    ..pyl)-4-phenylpiperidin-4-yl)-N-methylacetamide), R820 (3-indolylcarbonyl-Hyp-Phg-N(Me)-Bzl) and R486 (H-Asp-Ser-Phe-Trp-beta-Ala-Leu-Met-NH2) were assessed against the intracerebroventricular (i.c.v...
  40. ncbi General experimental aspects of the use of isoelectric buffers in capillary electrophoresis
    A Bossi
    University of Verona, Department of Agricultural and Industrial Biotechnologies, Italy
    J Chromatogr A 853:71-82. 1999
    ..85], iminodiacetic acid (IDA, pI 2.23), aspartic acid (Asp, pI 2.77) and glutamic acid (Glu, pI 3.22)...
  41. pmc Reconstructing phylogenies and phenotypes: a molecular view of human evolution
    Brenda J Bradley
    Department of Zoology and Christ s College, University of Cambridge, UK
    J Anat 212:337-53. 2008
    ..Loci involved in speech (e.g. FOXP2), brain development (e.g. ASPM), and skull musculature (e.g. MYH16) have been of particular interest, but some surprising candidate loci (e.g...
  42. ncbi Structure-activity relationship of calcitonin gene related peptide
    K Morita
    Research Laboratory, Toyo Jozo Co, Ltd, Shizuoka, Japan
    Horm Metab Res 21:666-8. 1989
    ..A chicken CGRP analogue with replacement of Asp at position 14 by Gly (as in human CGRP) showed great reduction of activity...
  43. ncbi Generation of tryptic maps of alpha- and beta-globin chains by capillary electrophoresis in isoelectric buffers
    L Capelli
    Department of Agricultural and Industrial Biotechnologies, University of Verona, Italy
    J Chromatogr A 791:313-22. 1997
    ..In 30 mM Asp (pH 3.0) or 20 mM Asp (pH 3.1) resolution of these two peptides is fully restored...
  44. ncbi Synthesis and effect of shortened oostatic decapeptide (TMOF) analogs with isosteric structures on reproduction of Neobellieria bullata
    J Marik
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague
    J Pept Res 57:401-8. 2001
    Oligopeptides 2a-2d derived from the oostatic decapeptide (TMOF) sequence, H-Tyr-Asp-Pro-Ala-Pro-Pro-Pro-Pro-Pro-Pro-OH (1a) and containing isosteric structures were synthesized and assayed to determine their effect during reproduction ..
  45. ncbi A monoclonal antibody against the glutaraldehyde-conjugated polyamine, putrescine: application to immunocytochemistry
    K Fujiwara
    Department of Applied Life Science, Faculty of Engineering, Sojo University, Ikeda 4 22 1, Kumamoto 860 0082, Japan
    Histochem Cell Biol 115:471-7. 2001
    ..On the other hand, the same method but using a previously prepared ASPM-29 mAb, specific for spermine (Spm) and Spd, produced intense immunostaining in the cytoplasm of all the three cell ..
  46. ncbi [Mutations of HIV-1 RT gene isolated from patients treated with AZT]
    M Kondo
    Department of Virology, Kanagawa Prefectural Public Health Laboratories
    Kansenshogaku Zasshi 67:185-9. 1993
    ..Some of the 14 clones also had other mutations at codon 67 (Asp-->Asn or Ser), codon 70 (Lys-->Arg) and codon 219 (Lys-->Glu)...
  47. ncbi Liquid chromatographic determination of D- and L-amino acids by derivatization with o-phthaldialdehyde and N-isobutyryl-L-cysteine. Applications with reference to the analysis of peptidic antibiotics, toxins, drugs and pharmaceutically used amino acids
    H Bruckner
    Institute of Food Technology, University of Hohenheim, Stuttgart, Germany
    J Chromatogr A 711:201-15. 1995
    ..Further, the enantiomeric ratios of pharmaceutically used AA formulations containing racemic DL-Ser, DL-Asp and DL-Met were determined, and the AA drugs L-Asp and L-Trp were tested negatively for the presence of the ..
  48. ncbi Glutamate 83 is important for stabilization of domain-domain conformation of Thermus aquaticus glycerol kinase
    H S Huang
    School of Pharmaceutical Sciences, Nagasaki University, Bunkyo-machi, Nagasaki 852-8521, Japan
    J Biochem 128:207-11. 2000
    ..Three residues (Arg-82, Glu-83, and Asp-244) of T...
  49. ncbi Identification of four ovarian receptor proteins that bind vitellogenin but not other homologous plasma lipoproteins in the rainbow trout, Oncorhynchus mykiss
    C R Tyler
    Department of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex, UK
    J Comp Physiol B 166:11-20. 1996
    ..in the lipoprotein family, including a sequence that is believed to act as the internalisation signal [Phe-Asp-Phe-Tyr-] and a sequence identity with the recently characterised chicken vitellogenin/very low density lipoprotein ..
  50. ncbi Demonstration of a heparin-binding site in serum amyloid P component using affinity capillary electrophoresis as an adjunct technique
    N H Heegaard
    Department of Autoimmunology, Statens Seruminstitut, Copenhagen S, Denmark
    J Chromatogr A 717:83-90. 1995
    ..Peptide fragments were generated from amyloid P component by treatment with Glu-C and Asp-N endoproteinases...
  51. doi Secreted phosphoprotein 1 upstream invasive network construction and analysis of lung adenocarcinoma compared with human normal adjacent tissues by integrative biocomputation
    Ying Sun
    Biomedical Center, School of Electronics Engineering, Beijing University of Posts and Telecommunications, Beijing, China
    Cell Biochem Biophys 56:59-71. 2010
    ..inhibition); sequence variant module appears in human normal adjacent tissues (COL11A1_1, MKI67, MMP11 activation; ASPM, COL10A1, COL3A1, NEK2, TMPRSS4, TOP2A_2 inhibition), whereas in lung adenocarcinoma (COL11A1_2, COL1A2, HMMR, ..
  52. ncbi The functional significance of the second extracellular loop of thyrotropin receptor in thyrotropin- and thyroid stimulating antibody-dependent signal transduction
    M Kaneshige
    Third Department of Internal Medicine, University of Yamanashi Medical School, Japan
    Horm Metab Res 27:267-71. 1995
    ..cDNAs which encode a hydrophobic peptide (ATVLVVPM) and a hydrophilic peptide (GTTRTVAM) between +572 Met and +573 Asp were transfected into Chinese hamster ovary (CHO) cells to develop F-cell lines and R-cell lines, respectively...
  53. pmc Molecular dynamics simulation of Pf1 coat protein
    D J Tobias
    Department of Chemistry, University of Pennsylvania, Philadelphia 19104 6323
    Biophys J 64:670-5. 1993
    ..with some of the charged residues present in the Pf1 coat protein sequence suggest that interactions between the Asp 14 and Asp 18 sidechains and the peptide backbone are responsible for the formation of the mobile loop...
  54. ncbi Emerging connection between centrosome and DNA repair machinery
    Mikio Shimada
    Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto, Japan
    J Radiat Res 50:295-301. 2009
    ..that the development of microcephaly is likely caused by defective expression of centrosome proteins, such as ASPM, which are also involved in the response to IR...
  55. ncbi [Pyoverdins from Pseudomonas putida]
    I Gwose

    Z Naturforsch C 47:487-502. 1992
    ..or a succinamoyl residue and at the carboxy group with the N-terminus of L-Ser-L-Thr-D-Ser-L-Orn-L-threo-(OH)Asp-[D-Glu + L-Dab]*-L-Ser-D-allo-Thr- L-c(OH)Orn...
  56. pmc Two types of RAS mutants that dominantly interfere with activators of RAS
    V Jung
    Cold Spring Harbor Laboratory, New York 11724
    Mol Cell Biol 14:3707-18. 1994
    ..M. Cooper, Mol. Cell. Biol. 8:3235-3243, 1988), blocked only conjugation, whereas a second type of mutation, at Asp-62, interfered with conjugation, sporulation, and cellular morphology...
  57. ncbi Total resolution of 17 DL-amino acids labelled with a fluorescent chiral reagent, R(-)-4-(3-isothiocyanatopyrrolidin-1-y1)-7-(N,N-dimethylaminosulfonyl)- 2,1,3-benzoxadiazole, by high-performance liquid chromatography
    D Jin
    Department of Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Chromatogr A 822:215-24. 1998
    ..The results showed that some of the L-amino acids, i.e., Glu, Asp, Ser, Gly, Ala, Thr, Pro, Lys, Phe and Met, were found in the methanol extracts of yogurt...
  58. ncbi Chromatographic resolution of tryptophan enantiomers with L-Leu-L-Leu-L-Leu peptide effects of mobile phase composition and chromatographic support
    D B Kaufman
    Department of Chemical Engineering, North Carolina State University, Raleigh 27695-7905, USA
    J Chromatogr A 874:21-6. 2000
    ..However, resin-immobilized Leu-Leu-Asp-Leu-Leu-Leu, Leu-Leu-Glu-Leu-Leu-Leu, and Leu-Leu-Leu-Glu-Leu-Leu peptides, with ion-pairing sites designed to ..
  59. ncbi Modulation of neuropeptide effects by achatin-I, an Achatina endogenous tetrapeptide
    G J Liu
    Department of Physiology, Gifu University School of Medicine, Japan
    Eur J Pharmacol 240:139-45. 1993
    Achatin-I (Gly-D-Phe-L-Ala-L-Asp), an endogenous tetrapeptide in the ganglia of Achatina fulica Férussac, at 3 x 10(-6) M suppressed both the inward current (Iin) of an Achatina giant neurone, PON (periodically oscillating neurone), ..
  60. ncbi [Age-related changes in the cytolytic activity of aspartyl aminopeptidase in the cerebral cortex of the rat]
    M C Iribar
    , Facultad de Medicina, Universidad de Granada,
    Rev Neurol 25:37-9. 1997
    ..OBJECTIVE: Since the enzyme aspartyl-aminopeptidase (Asp-AP) may play a role in modifying the concentration of the cytotoxic amino acids glutamate and aspartate, we studied ..
  61. ncbi [Mechanism of resistance of Shigella flexneri 2a resistant to new quinolone antibiotics]
    K Oonaka
    Department of Environmental Microbiology, Collge of Environmental Health, Azabu University, Japan
    Kansenshogaku Zasshi 72:365-70. 1998
    ..DNA sequencing revealed that two amino acid substitutions, namely, Ser (TCG)-83-->Leu (TTG) and Asp (GAC)-87-->Gly (GGC), had occurred in the gyrA of all 3 strains isolated from the patients...
  62. ncbi Detection of neutral and charged mutations in alpha- and beta-human globin chains by capillary zone electrophoresis in isoelectric, acidic buffers
    A Saccomani
    University of Verona, Department of Agricultural and Industrial Biotechnology, Italy
    J Chromatogr A 832:225-38. 1999
    ..At this low operative pH, however, charged mutants, involving substitutions of acidic amino acids (Glu and Asp) are not detected, since these residues are extensively protonated...
  63. ncbi Quantitation of protein binding to the capillary wall in acidic, isoelectric buffers and means for minimizing the phenomenon
    E Olivier
    Department of Agricultural and Industrial Biotechnology, University of Verona, Italy
    J Chromatogr A 894:273-80. 2000
    ..8% and 0.5%, respectively. When the same globin chain separations are performed in Asp and 7 M urea (pH 3.7), the situation is much worse: 44% protein is adsorbed in a ternary mixture of 0...
  64. ncbi Hydrophilic interactions between charged amino acids and the effect of ions on the strength of interaction
    T Cserhati
    Central Research Institute for Chemistry of Hungarian Academy of Sciences, Budapest
    Z Naturforsch C 45:79-83. 1990
    ..The dependence of the lipophilicity of Arg, Lys and Orn on the concentration of Glu, Asp, Gln and Asn in the eluent was considered to be related to the strength of interaction...
  65. ncbi Seroepidemiology status of Nepalese against hemolytic streptococcal infection in Katmandu
    H Shibata
    Department of Clinical Laboratory, Hyogo College of Medicine
    Kansenshogaku Zasshi 66:314-8. 1992
    ..ASO), anti-streptokinase (ASK), anti-deoxyribonuclease-B (ADN-B) and anti-Streptococcus polysaccharide (ASP) was 60-480 (T.U.), 40-1024 (titer), 60-1280 (titer) and less than 2-128 (Unit), respectively...
  66. ncbi Porin of Rhodobacter capsulatus: biochemical and functional characterization
    D Woitzik
    , Mikrobiologie, , Freiburg, Bundesrepublik Deutschland
    Z Naturforsch C 45:576-82. 1990
    ..0, was obtained on isoelectric focusing. Gas-phase sequencing of the 23 N-terminal residues revealed Glu-Val-Lys-Leu-Ser-Gly-Asp-Ala-Arg-Met-Gly-Val-Met-Tyr-Asn-Gly-Asp-Asp- X-Asn- Phe-Ser-Ser.
  67. pmc The use of synthetic analogues of Arg-Gly-Asp (RGD) and soluble receptor of tumor necrosis factor to prevent acute and chronic experimental liver injury
    R Bruck
    Department of Gastroenterology, E. Wolfson Medical Center, Holon, Israel
    Yale J Biol Med 70:391-402. 1997
    ..The target epitope of several such integrin receptors is the Arg-Gly-Asp (RGD) sequence, a cell adhesion motif shared by several matrix-associated adhesive glycoproteins...
  68. ncbi Plasmodium falciparum in Kenya: high prevalence of drug-resistance-associated polymorphisms in hospital admissions with severe malaria in an epidemic area
    S A Omar
    Centre for Biotechnology Research Development, Kenya Medical Research Institute, P O Box 54840, Mbagathi Road, Nairobi, Kenya
    Ann Trop Med Parasitol 95:661-9. 2001
    ..sampled carried parasites with the (Asn)86(Tyr) point mutation in the pfmdr1 gene (chromosome 5), 20 (83%) had an (Asp)1246(Tyr) mutation and 18 (82%) had both of these mutations...
  69. ncbi A multidimensional proteomic approach to identify hypertrophy-associated proteins
    Merry L Lindsey
    Division of Cardiothoracic Surgery Research, Department of Surgery, Medical University of South Carolina, Charleston, SC, USA
    Proteomics 6:2225-35. 2006
    ..LIM proteins, thioredoxin, myoglobin, fatty acid binding protein 3, the abnormal spindle-like microcephaly protein (ASPM), and cytoskeletal proteins such as actin and myosin...
  70. pmc Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1
    Laura E Swan
    Department of Cell Biology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA
    Proc Natl Acad Sci U S A 107:3511-6. 2010
    ..Here, we identify two closely related endocytic proteins, Ses1 and Ses2, which interact with the ASH-RhoGAP-like (ASPM-SPD-2-Hydin homology and Rho-GTPase Activating Domain-like) domain of OCRL...
  71. pmc Association between AVPR1A, DRD2, and ASPM and endophenotypes of communication disorders
    Catherine M Stein
    Departments of aEpidemiology and Biostatistics bPsychological Sciences cPediatrics dGenetics eCenter for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, USA
    Psychiatr Genet 24:191-200. 2014
    ..disorders, we focused on three genes related to brain and central nervous system functioning: the dopamine D2 receptor (DRD2) gene, the arginine-vasopressin receptor 1a (AVPR1A) gene, and the microcephaly-associated protein gene (ASPM).
  72. doi Identification and biochemical characterization of polyamine oxidases in amphioxus: Implications for emergence of vertebrate-specific spermine and acetylpolyamine oxidases
    Huihui Wang
    Laboratory for Evolution and Development, Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao 266003, China Department of Marine Biology, Ocean University of China, Qingdao 266003, China
    Gene 575:429-37. 2016
    ..plant PAOs oxidize spermine (Spm), spermidine (Spd) and their acetylated derivatives, N(1)-acetylspermine (N(1)-Aspm) and N(1)-acetylspermidine (N(1)-Aspd), while yeast PAOs oxidize Spm, N(1)-Aspm and N(1)-Aspd, but not Spd...
  73. ncbi Sequence analysis of the D1 and D2 reaction center proteins of photosystem II
    B Svensson
    Department of Biochemistry, Arrhenius Laboratories for Natural Sciences, University of Stockholm, Sweden
    Z Naturforsch C 46:765-76. 1991
    ..Most prominent is the presence of two conserved carboxylic aminoacids, D1-Asp 170 and D1-Glu 189...
  74. ncbi Synthesis and activity of dermorphin-growth hormone releasing factor hybrid peptides
    M Marastoni
    Department of Pharmaceutical Sciences, University of Ferrara, Italy
    Arzneimittelforschung 39:639-41. 1989
    ..The substitution of Phe3 for Asp and Glu in dermorphin or its N-terminal acetylation produced peptides with no affinity for opioid receptors but ..
  75. ncbi [Reverse transcriptase gene analysis of HIV-1 mutants cultured in the presence of AZT]
    M Kondo
    Department of Virology, Kanagawa Prefectural Public Health Laboratories
    Kansenshogaku Zasshi 67:992-7. 1993
    ..Some of the 22 clones also had other mutations at codon 67 (Asp-->Ser), codon 70 (Lys-->Arg) and codon 219 (Lys-->Glu or Gln)...
  76. ncbi Analysis of the sequence requirements for glycosylphosphatidylinositol anchoring of Saccharomyces cerevisiae Gas1 protein
    C Nuoffer
    Biocenter, University of Basel, Switzerland
    J Biol Chem 268:10558-63. 1993
    ..After Asn, which is the most efficient anchor attachment site, Ser, Gly, Ala, Asp, and Cys function with decreasing effectiveness...
  77. ncbi Structure and characterization of isopyoverdin from Pseudomonas putida BTP1 and its relation to the biogenetic pathway leading to pyoverdins
    P Jacques
    , , Bundesrepublik Deutschland
    Z Naturforsch C 50:622-9. 1995
    ..with the 5-carboxyl group of L-glutamic acid and its carboxyl group with the N-terminus of the peptide L-Asp-L-Ala-L-Asp-D-N5-Ac-N5-OH-Orn-L-Ser-L-c-N5-OH-Orn...
  78. ncbi Synthesis, radiolabeling and biological activity of peptide oostatic hormone and its analogues
    J Hlavacek
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague, Czech Republic
    J Pept Res 50:153-8. 1997
    ..Peptides 3a-3d were synthesized in solution by the fragment condensation of Boc-Tyr-Asp(OtBu)-Pro-Ala-Pro-OH (2f) with Pro oligopeptides H-(Pro)2-5-OtBu...
  79. ncbi Determination of submicromolar concentrations of neurotransmitter amino acids by fluorescence detection using a modification of the 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate method for amino acid analysis
    H Liu
    Waters Corporation, Milford, MA 01757, USA
    J Chromatogr A 828:383-95. 1998
    A sensitive method for quantitatively determining submicromolar levels of neurotransmitter amino acids (e.g. Asp, Glu and gamma-aminobutyric acid) in microdialysates from brain and cerebrospinal fluids is reported...
  80. ncbi A translocation breakpoint disrupts the ASPM gene in a patient with primary microcephaly
    Bruno Pichon
    Service de Genetique Medicale, Hopital Erasme, Universite Libre de Bruxelles, 808 Route de Lennik, 1070 Bruxelles, Belgium
    Eur J Hum Genet 12:419-21. 2004
    ..breakpoint previously reported in a patient with apparently sporadic primary microcephaly, at 1q31, where locus MCPH5 maps. The patient was lost to follow-up, and we sampled a maternal aunt who carried the familial translocation...
  81. pmc Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion
    Natalay Kouprina
    Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland, USA
    PLoS Biol 2:E126. 2004
    ..Mutations in ASPM, which encodes the human homologue of a fly protein essential for spindle function, are the most common known cause ..
  82. ncbi Comparison of proportional hazard model and neural network models in a real data set of intensive care unit patients
    Machi Suka
    Department of Preventive Medicine, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa 216 8511, Japan
    Stud Health Technol Inform 107:741-5. 2004
    ..We conducted a comparative study of PHM and two types of NNM, that is, aggregate single point model (ASPM) and multiple point model (MPM), using a real data set of intensive care unit patients...
  83. ncbi Patterns of interaction between Populus Esch5 and Piriformospora indica: a transition from mutualism to antagonism
    M Kaldorf
    Fachbereich Biologie, Spezielle Botanik und Mykologie, Philipps Universitat Marburg, Karl von Frisch Strasse 8, 32032 Marburg, Germany
    Plant Biol (Stuttg) 7:210-8. 2005
    ..Detached Populus leaves remained vital for 4 - 5 weeks on sterile agar media or on AspM medium with pre-grown P. indica...
  84. ncbi Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ
    Patrick D Evans
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Gene 375:75-9. 2006
    ..at least approximately, that seen in two other previously identified primary microcephaly genes, microcephalin and ASPM. We also briefly discuss CENPJ, which similarly exhibits higher rate of protein evolution in primates as compared ..
  85. pmc Linguistic tone is related to the population frequency of the adaptive haplogroups of two brain size genes, ASPM and Microcephalin
    Dan Dediu
    School of Philosophy, Psychology and Language Sciences, University of Edinburgh, 14 Buccleuch Place, Edinburgh EH8 9LN, United Kingdom
    Proc Natl Acad Sci U S A 104:10944-9. 2007
    ..Specifically, we focus on the derived haplogroups of the brain growth and development-related genes ASPM and Microcephalin, which show signs of natural selection and a marked geographic structure, and on linguistic tone, ..
  86. doi Mutations in the pericentrin (PCNT) gene cause primordial dwarfism
    Anita Rauch
    Institute of Human Genetics, University Hospital Erlangen, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Science 319:816-9. 2008
    ..Absence of PCNT results in disorganized mitotic spindles and missegregation of chromosomes. Mutations in related genes are known to cause primary microcephaly (MCPH1, CDK5RAP2, ASPM, and CENPJ).
  87. doi Expression profiles of SV40-immortalization-associated genes upregulated in various human cancers
    Hyun Min Jung
    Graduate School of Life Science and Biotechnology, College of Medicine, Pochon CHA University, Seongnam, South Korea
    J Cell Biochem 106:703-13. 2009
    ..We chose eight known genes located on the overrepresented chromosomes of non-small-cell lung cancers (NSCLCs). ASPM, RFC4, C3orf26, BXDC2, C15orf44, AURKA, C20orf77, and RBMX were upregulated in immortalized cells, cancer cells, ..
  88. doi Are languages really independent from genes? If not, what would a genetic bias affecting language diversity look like?
    Dan Dediu
    Max Planck Institute for Psycho linguistics, Wundtlaan 1, 6525 XD Nijmegen, The Netherlands
    Hum Biol 83:279-96. 2011
    ..relationship between the distribution of tone languages and two genes related to brain growth and development, ASPM and Microcephalin, and I discuss the relevance of such genetic biasing for language evolution, change, and diversity...
  89. pmc ASPM regulates Wnt signaling pathway activity in the developing brain
    Joshua J Buchman
    Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 25:1909-14. 2011
    ..Mutations in Abnormal Spindle Microcephaly (ASPM) are the most common cause of MCPH...
  90. doi Molecular features of triple negative breast cancer cells by genome-wide gene expression profiling analysis
    Masato Komatsu
    Division of Genome Medicine, Institute for Genome Research, The University of Tokushima, Tokushima, Japan
    Int J Oncol 42:478-506. 2013
    ..we focused on cell cycle regulators, asp (abnormal spindle) homolog, microcephaly-associated (Drosophila) (ASPM) and centromere protein K (CENPK) as novel therapeutic targets for TNBC...
  91. pmc Elevated cyclin B2 expression in invasive breast carcinoma is associated with unfavorable clinical outcome
    Emman Shubbar
    Sahlgrenska Cancer Center, Department of Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg SE 41345, Sweden
    BMC Cancer 13:1. 2013
    ..The purpose of the present study was to investigate the prognostic value of the candidate biomarkers CCNB2, ASPM, CDCA7, KIAA0101, and SLC27A2 in breast cancer.
  92. pmc Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinoma
    Gholamreza Bidkhori
    Laboratory of Systems Biology and Bioinformatics LBB, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    PLoS ONE 8:e67552. 2013
    ..In few modules, the genes such as CCNA2 (Cyclin A2), CCNB2 (Cyclin B2), CDK1, CDK5, CDC27, CDCA5, CDCA8, ASPM, BUB1, KIF15, KIF2C, NEK2, NUSAP1, PRC1, SMC4, SYCE2, TFDP1, CDC42 and ARHGEF9 are present that play a crucial role ..
  93. doi The microcephaly protein Asp regulates neuroepithelium morphogenesis by controlling the spatial distribution of myosin II
    Maria A Rujano
    UMR144, CNRS Institut Curie, 12 rue Lhomond, 75005 Paris, France
    Nat Cell Biol 15:1294-306. 2013
    Mutations in ASPM are the most frequent cause of microcephaly, a disorder characterized by reduced brain size at birth...
  94. doi Simplified gyral pattern in severe developmental microcephalies? New insights from allometric modeling for spatial and spectral analysis of gyrification
    D Germanaud
    INSERM, UMR 1129, F 75015 Paris, France CEA, Neurospin, UNIACT, UNIPEDIA, F 91191 Gif sur Yvette, France AP HP, Hopital Robert Debre, Service de Neuropédiatrie et Pathologie Métabolique, F 75019 Paris, France Univ Paris Diderot, Sorbonne Paris Cité, Faculté de Médecine Paris Diderot, F 75010 Paris, France Electronic address
    Neuroimage 102:317-31. 2014
    ..of gyrification (Spangy), we tested whether the gyral simplification in groups of severe microcephalies related to ASPM, PQBP1 or fetal-alcohol-syndrome could be fully explained by brain size reduction according to the allometric ..
  95. pmc Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing
    Reika Iwakawa
    Division of Genome Biology, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Carcinogenesis 36:616-21. 2015
    ..Mutated alleles were expressed in 8 of the 36 genes, TMEM132D, SPTA1, VPS13B, CSMD2, ANK2, ASTN1, ASPM and FBN3...
  96. pmc The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division
    Ankur A Gholkar
    Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Rep 14:180-8. 2016
    ..These results could help explain how mutation of MID2 leads to misregulation of microtubule organization and the downstream disease pathology associated with X-linked intellectual disabilities. ..
  97. doi Molecular analysis of 23 Pakistani families with autosomal recessive primary microcephaly using targeted next-generation sequencing
    Rongrong Wang
    McKusick Zhang Center for Genetic Medicine, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China
    J Hum Genet 62:299-304. 2017
    ..that were pathogenic or likely to be pathogenic in 22 families, including 18 families with known mutations in ASPM, three with novel mutations in WDR62 and one with a novel in-frame deletion mutation in CASC5...
  98. doi Controversial role of the possible oxyntic stem cell marker ASPM in gastric cancer
    Fan Wang
    Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China
    J Pathol . 2016
    ..We found the results of the study were controversial...
  99. ncbi Genetic studies of autosomal recessive primary microcephaly in 33 Pakistani families: Novel sequence variants in ASPM gene
    Asma Gul
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University Islamabad, Islamabad, Pakistan
    Neurogenetics 7:105-10. 2006
    ..Mutations in the ASPM gene at the MCPH5 locus appear to be the most common cause of MCPH...
  100. pmc The microtubule-associated protein ASPM regulates spindle assembly and meiotic progression in mouse oocytes
    Xiao Ling Xu
    Institute of Animal Husbandry and Veterinary Medicine, Beijing Municipal Academy of Agriculture and Forestry Sciences, Beijing, China
    PLoS ONE 7:e49303. 2012
    The microtubule-associated protein ASPM (abnormal spindle-like microcephaly-associated) plays an important role in spindle organization and cell division in mitosis and meiosis in lower animals, but its function in mouse oocyte meiosis ..

Research Grants8

  1. Centrosomin and Centrosomes in Cell Division
    Timothy L Megraw; Fiscal Year: 2012
    ..Mutations in genes for other centrosomal proteins like CDK5RAP2, Pericentrin, sas4 and Aspm, are the root cause of related syndromes that affect brain and/or body size, yet an understanding of the connection ..
  2. Neurogenesis: Career Development Plan in the Genetic and Modeling of Microcephaly
    STEPHANIE LEE BIELAS; Fiscal Year: 2011
    ..above I am proposing to model both Nucleoporin 107 (NUP107) and abnormal spindle-like microcephaly associated (ASPM)...
  3. STEPHANIE LEE BIELAS; Fiscal Year: 2015
    ..above I am proposing to model both Nucleoporin 107 (NUP107) and abnormal spindle-like microcephaly associated (ASPM)...
  4. Switching Kinetics in Calmodulin-IQ Domain Complexes
    Anthony Persechini; Fiscal Year: 2009
    ..mutations in proteins containing IQ domains and numerous human diseases: Truncations and other mutations in the ASPM protein, which contains multiple IQ domain repeats, are associated with microcephaly, and the number of repeats ..
  5. ATMOSPHERIC PROTON MICROPROBE FOR TRACE ELEMENT ANALYSIS
    RAYMOND BOISSEAU; Fiscal Year: 1992
    DESCRIPTION (Adapted from Applicant's Abstract):The development of an Atmospheric Scanning Proton Microprobe (ASPM) for elemental analysis of organic specimens is proposed...
  6. Neural Bases of Auditory Processing Disorders in Adults
    Patrick Wong; Fiscal Year: 2007
    ..2) Whether it is feasible to use MRI to identify neurophysiologic anomalies in APD adults. If so, whether APD is associated with a collection of unifying or diverse neurophysiologic anomalies. [unreadable] [unreadable]..
  7. Acquisition of Mandarin Tones: A Cross-Sectional Study
    Patrick Wong; Fiscal Year: 2007
    ..For the rehabilitation of adults, it is especially important to understand how adults learn. [unreadable] [unreadable] [unreadable]..
  8. Evolution of vertebrate sensory genes
    Jianzhi Zhang; Fiscal Year: 2010
    ..These studies will also help understand human smell and taste variations and disorders. ..