Genomes and Genes
Gene Symbol: ARSB
Description: arylsulfatase B
Alias: ASB, G4S, MPS6, arylsulfatase B, N-acetylgalactosamine-4-sulfatase
Publications249 found, 100 shown here
- Structure of a human lysosomal sulfataseC S Bond
Department of Biochemistry, University of Sydney, NSW 2006 Australia
Structure 5:277-89. 1997..To understand the catalytic mechanism of sulfatases, and ultimately the determinants of their substrate specificities, we have determined the structure of N-acetylgalactosamine-4-sulfatase...
- Maroteaux-Lamy syndrome: functional characterization of pathogenic mutations and polymorphisms in the arylsulfatase B geneElena Garrido
Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Mol Genet Metab 94:305-12. 2008..syndrome) is an autosomal recessive lysosomal disorder caused by deficiency of N-acetylgalactosamine-4-sulfatase (ARSB), which is required for the degradation of dermatan sulfate...
- Arylsulfatase B regulates colonic epithelial cell migration by effects on MMP9 expression and RhoA activationSumit Bhattacharyya
Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Clin Exp Metastasis 26:535-45. 2009b>Arylsulfatase B (ASB; N-acetylgalactosamine-4-sulfatase; 4-sulfatase; ARSB) is the enzyme that removes 4-sulfate groups from N-acetylgalactosamine 4-sulfate, which combines with glucuronate to form the disaccharide unit of chondroitin-4-..
- Cell-bound IL-8 increases in bronchial epithelial cells after arylsulfatase B silencing due to sequestration with chondroitin-4-sulfateSumit Bhattacharyya
Department of Medicine, University of Illinois at Chicago, 840 S Wood Street, Chicago, IL 60612, USA
Am J Respir Cell Mol Biol 42:51-61. 2010..C4S) in mediating effects of IL-8, we silenced the enzyme N-acetylgalactosamine-4-sulfatase (arylsulfatase B [ASB]) that removes the 4-sulfate group from C4S, in the IB3-1 and C38 bronchial epithelial cell lines and in ..
- Extra-lysosomal localization of arylsulfatase B in human colonic epitheliumSanjiv V Prabhu
Department of Pathology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
J Histochem Cytochem 59:328-35. 2011The enzyme arylsulfatase B (N-acetylgalactosamine-4-sulfatase; ARSB; ASB) removes 4-sulfate groups from the sulfated glycosaminoglycans (sGAG) chondroitin-4-sulfate (C4S) and dermatan sulfate (DS)...
- Hypoxia reduces arylsulfatase B activity and silencing arylsulfatase B replicates and mediates the effects of hypoxiaSumit Bhattacharyya
Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
PLoS ONE 7:e33250. 2012This report presents evidence of 1) a role for arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) in mediating intracellular oxygen signaling; 2) replication between the effects of ARSB silencing and hypoxia on sulfated ..
- Increased arylsulfatase B activity in cystic fibrosis cells following correction of CFTRSumit Bhattacharyya
Department of Medicine, University of Illinois at Chicago and Jesse Brown VAMC, Chicago, IL 60612, USA
Clin Chim Acta 380:122-7. 2007..Since the enzyme arylsulfatase B (ASB) catalyzes hydrolysis of the sulfate ester of N-acetylgalactosamine 4-sulfate, a component of dermatan ..
- Distinct effects of N-acetylgalactosamine-4-sulfatase and galactose-6-sulfatase expression on chondroitin sulfatesSumit Bhattacharyya
Department of Medicine, University of Illinois, Chicago, IL 60612, USA
J Biol Chem 283:9523-30. 2008The sulfatase enzymes, N-acetylgalactosamine-4-sulfatase (arylsulfatase B (ASB)) and galactose-6-sulfatase (GALNS) hydrolyze sulfate groups of CS. Deficiencies of ASB and GALNS are associated with the mucopolysaccharidoses...
- Mucopolysaccharidosis VIVassili Valayannopoulos
Reference Center for Inherited Metabolic Diseases, Necker Enfants Malades Hospital, Paris, France
Orphanet J Rare Dis 5:5. 2010..VI) is a lysosomal storage disease with progressive multisystem involvement, associated with a deficiency of arylsulfatase B leading to the accumulation of dermatan sulfate...
- Arylsulfatase B regulates interaction of chondroitin-4-sulfate and kininogen in renal epithelial cellsSumit Bhattacharyya
University of Illinois at Chicago, Chicago, IL 60612, USA
Biochim Biophys Acta 1802:472-7. 2010The enzyme arylsulfatase B (N-acetylgalactosamine 4-sulfatase; ASB; ARSB), which removes 4-sulfate groups from the nonreducing end of chondroitin-4-sulfate (C4S;CSA) and dermatan sulfate, has cellular effects, beyond those associated ..
- Arsenic metabolism in seaweed-eating sheep from Northern ScotlandJ Feldmann
University of Aberdeen, Department of Chemistry, Scotland, UK
Fresenius J Anal Chem 368:116-21. 2000..DMAA), monomethylarsonic acid (MMAA), trimethylarsine oxide (TMAO), tetramethylarsonium ion (TMA), arsenobetaine (AsB), arsenocholine (AsC), dimethylarsinoyl ethanol (DMAE) and four common dimethylarsinoylribosides (arsenosugars)...
- Steroid sulfatase, arylsulfatases A and B, galactose-6-sulfatase, and iduronate sulfatase in mammary cells and effects of sulfated and non-sulfated estrogens on sulfatase activitySumit Bhattacharyya
Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States Jesse Brown VAMC, Chicago, IL, United States
J Steroid Biochem Mol Biol 103:20-34. 2007..enzymes, including steroid sulfatase (STS; arylsulfatase C), arylsulfatase A (ASA; cerebroside sulfatase), arylsulfatase B (ASB; N-acetylgalactosamine-4-sulfatase), galactose-6-sulfatase (GALNS), and iduronate-2-sulfatase (IDS), was ..
- Intrathecal administration of recombinant human N-acetylgalactosamine 4-sulfatase to a MPS VI patient with pachymeningitis cervicalisMaría Verónica Muñoz-Rojas
Post Graduation Program in Child and Adolescent Health, UFRGS, Porto Alegre, RS, Brazil
Mol Genet Metab 99:346-50. 2010..We report the use of intrathecal (IT) recombinant human N-acetylgalactosamine 4-sulfatase (arylsulfatase B, or ASB) in a MPS VI child with spinal cord compression whose parents initially refused the surgical ..
- Long-term intra-articular administration of recombinant human N-acetylgalactosamine-4-sulfatase in feline mucopolysaccharidosis VIDyane Auclair
Lysosomal Diseases Research Unit, Department of Genetic Medicine, Children, Youth and Women s Health Service, SA, Australia
Mol Genet Metab 91:352-61. 2007..These data support the view that intra-articular therapy may be a good option for preventing the development of the severe articular pathology in MPS VI...
- Recombinant caprine 3H-[N-acetylglucosamine-6-sulfatase] and human 3H-[N-acetylgalactosamine-4-sulfatase]: plasma clearance, tissue distribution, and cellular uptake in the ratM Z Jones
Department of Chemical Pathology, Women s and Children s Hospital, North Adelaide, South Australia, Australia
J Mol Neurosci 11:223-32. 1998..The low level of enzyme recovered from the brain suggests that modification of rc6S will be necessary to achieve sufficient enzyme uptake into the CNS for effective therapy of MPS IIID...
- Enzyme replacement therapy for mucopolysaccharidosis VI: evaluation of long-term pulmonary function in patients treated with recombinant human N-acetylgalactosamine 4-sulfatasePaul Harmatz
Children s Hospital and Research Center Oakland, CA 94609, USA
J Inherit Metab Dis 33:51-60. 2010..function was studied in patients during long-term enzyme replacement therapy (ERT) with recombinant human arylsulfatase B (rhASB; rhN-acetylgalactosamine 4-sulfatase)...
- High-performance liquid chromatography-inductively coupled plasma mass spectrometry based method for the determination of organic arsenic feed additives and speciation of anionic arsenics in animal feedPeilong Wang
Institute of Quality Standards and Testing Techniques for Agriculture Products, China Agricultural Academy of Science, Beijing, China
J Agric Food Chem 58:5263-70. 2010..chromatography coupled to tandem mass spectrometry (LC-MS/MS) was used as an assistant tool to screen arsenobetain (AsB) in the feed samples by monitoring the reaction at m/z 179-->120...
- Replacement therapy in Mucopolysaccharidosis type VI: advantages of early onset of therapyDyane Auclair
Lysosomal Diseases Research Unit, Department of Chemical Pathology, Women s and Children s Hospital, 72 King William Road, North Adelaide, SA 5006, Australia
Mol Genet Metab 78:163-74. 2003..Overall improvement in the disease condition (at physical, neurological, and skeletal levels) was most pronounced for cats treated from birth compared with cats treated at a later age...
- Enzyme replacement therapy for mucopolysaccharidosis VI: a phase 3, randomized, double-blind, placebo-controlled, multinational study of recombinant human N-acetylgalactosamine 4-sulfatase (recombinant human arylsulfatase B or rhASB) and follow-on, open-lPaul Harmatz
Children s Hospital and Research Center at Oakland, California 94609, USA, and Children s Hospital, University of Mainz, Germany
J Pediatr 148:533-539. 2006The objective of this Phase 3 study was to confirm the efficacy and safety of recombinant human arylsulfatase B (rhASB) treatment of mucopolysaccharidosis type VI (MPS VI; Maroteaux-Lamy syndrome), a rare, fatal lysosomal storage disease ..
- Long-term follow-up of endurance and safety outcomes during enzyme replacement therapy for mucopolysaccharidosis VI: Final results of three clinical studies of recombinant human N-acetylgalactosamine 4-sulfatasePaul Harmatz
Children s Hospital and Research Center Oakland, 747 52nd Street, Oakland, CA 94609, USA
Mol Genet Metab 94:469-75. 2008The objective of this study was to evaluate the long-term clinical benefits and safety of recombinant human arylsulfatase B (rhASB) treatment of mucopolysaccharidosis type VI (MPS VI: Maroteaux-Lamy syndrome), a lysosomal storage disease...
- Arsenic-resistant bacteria associated with roots of the wild Cirsium arvense (L.) plant from an arsenic polluted soil, and screening of potential plant growth-promoting characteristicsLucia Cavalca
Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, Universita degli Studi di Milano, Via Celoria 2, Milano 20133, Italy
Syst Appl Microbiol 33:154-64. 2010..Most strains possessed the ArsC, ArsB and ACR3 genes homologous to arsenate reductase and to the two classes of arsenite efflux pumps, respectively, ..
- Characterization of iodothyronine sulfatase activities in human and rat liver and placentaMonique H A Kester
Department of Internal Medicine, Erasmus University Medical School, 3000 DR Rotterdam, The Netherlands
Endocrinology 143:814-9. 2002..hydrolysis of iodothyronine sulfates by homogenates of V79 cells expressing the human arylsulfatases A (ARSA), B (ARSB), or C (ARSC; steroid sulfatase), as well as tissue fractions of human and rat liver and placenta...
- Arcuate nucleus transcriptome profiling identifies ankyrin repeat and suppressor of cytokine signalling box-containing protein 4 as a gene regulated by fasting in central nervous system feeding circuitsJ Y Li
Department of Surgery, University of Michigan, Ann Arbor, 48109, USA
J Neuroendocrinol 17:394-404. 2005..One of the down-regulated mRNAs was ankyrin-repeat and suppressor of cytokine signalling box-containing protein 4 (Asb-4)...
- Altered mRNA abundance of ASB15 and four other genes in skeletal muscle following administration of beta-adrenergic receptor agonistsTara G McDaneld
Department of Animal Sciences, Purdue University, West Lafayette 47907 2054, USA
Physiol Genomics 16:275-83. 2004..Changes in rat Asb-15 mRNA were measured at 30 min, 12 h, and 24 h following intraperitoneal injections of each compound...
- Assessing the measurement precision of various arsenic forms and arsenic exposure in the National Human Exposure Assessment Survey (NHEXAS)Edo D Pellizzari
RTI International, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 114:220-7. 2006..arsenic, arsenate [As(V)], arsenite, dimethyl arsenic acid (DMA), monomethyl arsenic acid (MMA), arsenobetaine (AsB), and arsenocholine...
- Chloroquine reduces arylsulphatase B activity and increases chondroitin-4-sulphate: implications for mechanisms of action and resistanceSumit Bhattacharyya
Department of Medicine, University of Illinois at Chicago, 840 S, Wood St, CSN 440 M C 718 Chicago, IL 60612, USA
Malar J 8:303. 2009..and alters normal lysosomal processes, the effects of chloroquine on the lysosomal enzyme arylsulphatase B (ASB, N-acetylgalactosamine-4-sulphatase), which removes 4-sulphate groups from chondroitin-4-sulphate, were addressed...
- Clinical outcomes following hematopoietic stem cell transplantation for the treatment of mucopolysaccharidosis VISean Turbeville
BioMarin Pharmaceutical Inc, 105 Digital Drive, Novato, CA 94949, USA
Mol Genet Metab 102:111-5. 2011..MPS VI is characterized by an absence or deficiency of N-acetylgalactosamine 4-sulfatase (arylsulfatase B) resulting in accumulation of dermatan sulfate...
- Enzyme replacement therapy in Mucopolysaccharidosis VI: evidence for immune responses and altered efficacy of treatment in animal modelsD A Brooks
Department of Chemical Pathology, Women s and Children s Hospital, North Adelaide South Australia
Biochim Biophys Acta 1361:203-16. 1997..The development of high titre antibody may have a detrimental effect on the efficacy of ERT...
- Functional analysis of a chromosomal arsenic resistance operon in Pseudomonas fluorescens strain MSP3S Prithivirajsingh
Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston 77030, USA
Mol Biol Rep 28:63-72. 2001..Nucleotide sequencing revealed the presence of three open reading frames homologous to the arsR, arsB and arsC genes of arsenic resistance...
- Enzyme replacement therapy in mucopolysaccharidosis VI (Maroteaux-Lamy syndrome)Paul Harmatz
Pediatric Clinical Research Center, Children s Hospital and Research Center at Oakland, California 94606, USA
J Pediatr 144:574-80. 2004..To evaluate the safety and efficacy of weekly treatment with human recombinant N-acetylgalactosamine 4-sulfatase (rhASB) in humans with mucopolysaccharidosis type VI (MPS VI)...
- Sequencing and expression of two arsenic resistance operons with different functions in the highly arsenic-resistant strain Ochrobactrum tritici SCII24TRita Branco
IMAR Laboratory of Microbiology 3004 517 Coimbra, Portugal
BMC Microbiol 8:95. 2008..Organisms surviving in arsenic contaminated environments can have a diversity of mechanisms to resist to the harmful effects of arsenical compounds...
- Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis VI (Maroteaux-Lamy syndrome)Trisha A Duffey
Department of Chemistry, University of Washington, Seattle, Washington 98195, United States
Anal Chem 82:9587-91. 2010..4 μmol/(h L of blood), and an MPS-VI patient that had an activity of 0.12 μmol/(h L of blood). Results are also reported for the aryl sulfatase B assay in DBS from groups of normal felines and felines affected with MPS-VI...
- Speciation analysis of arsenic and selenium compounds in environmental and biological samples by ion chromatography-inductively coupled plasma dynamic reaction cell mass spectrometerRuoh Yun Wang
Department of Chemistry, National Sun Yat Sen University, Kaohsiung 80424, Taiwan
Anal Chim Acta 590:239-44. 2007..arsenite [As(III)], arsenate [As(V)], monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), arsenobetaine (AsB), selenite [Se(IV)] and selenate [Se(VI)]...
- [Construction and eukaryotic expression of recombinant plasmid encoding fusion protein of goat complement C3d and foot-and-mouth disease virus VP1]Jieyu Ling
State Key Laboratory of Agricultural Microbiology, Wuhan 430070, China
Sheng Wu Gong Cheng Xue Bao 24:209-13. 2008..The goat C3d gene was cloned and three copies were tandem-linked with the linker (G4S)2 sequence...
- Reversed papilledema in an MPS VI patient with galsulfase (Naglazyme) therapySelim T Koseoglu
Children s Hospital Oakland, 5275 Claremont Avenue, Oakland, CA 94618, USA
Int Ophthalmol 29:267-9. 2009..papilledema and improved visual acuity in an 11-year-old MPS VI patient receiving galsulfase (Naglazyme), an enzyme-replacement therapy (ERT) of recombinant human arylsulfatase B (rhASB) (Harmatz et al., J Pediatr 148(4), 533-539, 2006).
- A superfamily of metalloenzymes unifies phosphopentomutase and cofactor-independent phosphoglycerate mutase with alkaline phosphatases and sulfatasesM Y Galperin
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
Protein Sci 7:1829-35. 1998..Mutational changes in the vicinity of these residues in several sulfatases cause mucopolysaccharidosis (Hunter, Maroteaux-Lamy, Morquio, and Sanfilippo syndromes) and metachromatic leucodystrophy...
- Microsomal steroid sulfatase: interactions with cytosolic steroid sulfotransferasesF C Kauffman
Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
Chem Biol Interact 109:169-82. 1998..Unlike ARSA and ARSB, which are lysosomal, steroid sulfate sulfatase (ARSC, also known as STS) is localized exclusively in the ..
- Genes involved in arsenic transformation and resistance associated with different levels of arsenic-contaminated soilsLin Cai
State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, PR China
BMC Microbiol 9:4. 2009....
- Mutational analysis of mucopolysaccharidosis type VI patients undergoing a phase II trial of enzyme replacement therapyLitsa Karageorgos
Lysosomal Diseases Research Unit, Department of Genetic Medicine, Children, Youth and Women s Health Service, North Adelaide, SA 5006, Australia
Mol Genet Metab 90:164-70. 2007..syndrome) is a lysosomal storage disorder caused by mutations in the N-acetylgalactosamine-4-sulfatase (ARSB) gene. These mutations result in a deficiency of ARSB activity...
- Enzyme replacement therapy for mucopolysaccharidosis VI from 8 weeks of age--a sibling control studyJ J McGill
Department of Metabolic Medicine, Royal Children s Hospital, Hertson, QLD, Australia
Clin Genet 77:492-8. 2010..multisystem disorder caused by a deficiency of the lysosomal enzyme N-acetylgalactosamine-4-sulphatase (ASB)...
- A quantitative mannose 6-phosphate receptor-based in vitro assay for recombinant human N-acetylgalactosamine-4-sulfataseM Kleinig
Research and Development Division, CSL Limited, 45 Poplar Road, Parkville, Victoria, 3052, Australia
Anal Biochem 260:128-34. 1998..Other possible applications of this assay are also discussed...
- Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activityJi Yao Li
Department of Surgery, University of Michigan, Ann Arbor 48109 0346, United States
Cell Signal 19:1185-92. 2007b>Asb-4 is a gene that is specifically expressed in the hypothalamic energy homeostasis-associated areas and is down-regulated in the arcuate nucleus of fasted Sprague Dawley and obese Zucker rats...
- Meeting Report:The 7th ESPE Growth Plate Working Group Symposium - EUROGROP June 27th 2007, Helsinki, FinlandRazvan L Miclea
Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
Pediatr Endocrinol Rev 5:680-5. 2007..Abbreviations: 11beta-HSD: 11 Beta-Hydroxysteroid Dehydrogenase; Agc: Aggrecan; Aln: Alendronate; Asb- 4: Ankyrin Repeat and SOCS Box-Containing Protein 4; Atf6: Activating Transcription Factor6; BSP: Bisphosphonates; ..
- Ankyrin repeat and suppressor of cytokine signaling (SOCS) box-containing protein (ASB) 15 alters differentiation of mouse C2C12 myoblasts and phosphorylation of mitogen-activated protein kinase and AktT G McDaneld
Department of Animal Science, Iowa State University, Ames 50011, USA
J Anim Sci 86:2897-902. 2008Ankyrin repeat and suppressor of cytokine signaling box-containing protein (ASB) 15 is a novel ASB gene family member predominantly expressed in skeletal muscle...
- An Escherichia coli chromosomal ars operon homolog is functional in arsenic detoxification and is conserved in gram-negative bacteriaC Diorio
Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
J Bacteriol 177:2050-6. 1995..This chromosomal operon was cloned, sequenced, and found to consist of three cistrons which we named arsR, arsB, and arsC because of their strong homology to plasmid-borne ars operons...
- Targeted introduction of a diphtheria toxin resistant mutation into the chromosomal EF-2 locus of Pichia pastoris and expression of immunotoxin in the EF-2 mutantsYuan Yi Liu
National Institute of Mental Health, NIH, Bethesda, MD 28092 4034, USA
Protein Expr Purif 30:262-74. 2003..When used to express the secreted bivalent anti-T cell immunotoxin, A-dmDT390-bisFv(G4S), the EF-2 mutant strains showed increased viability compared to the non-mutated strains...
- Complete remissions in chemotherapy of lung cancer models induced in mice by asbestosWilliam E Smith
Health Research Institute, Fairleigh Dickinson University, Madison, NJ, USA
Mt Sinai J Med 72:23-32. 2005..After treatments with a nitrosourea (PCNU), mice bearing transplants of a large-cell carcinoma (ASB XIV) had complete remissions (CR) in 13 of 20 animals on a 15 mg/kg regimen, in 6 of 20 on an 8 mg/kg regimen, and ..
- Anchoring skeletal muscle development and disease: the role of ankyrin repeat domain containing proteins in muscle physiologyJin Ming Tee
Hubrecht Institute for Developmental Biology and Stem Cell Research University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
Crit Rev Biochem Mol Biol 45:318-30. 2010..with Notch and developmental stage-specific expression of the members of the Ankyrin repeat and SOCS box (ASB) containing family of proteins controlling compartment size and guiding the various steps of muscle specification...
- Effect of probiotic-, bacteriophage-, or organic acid-supplemented feeds or fermented soybean meal on the growth performance, acute-phase response, and bacterial shedding of grower pigs challenged with Salmonella enterica serotype TyphimuriumE Gebru
Laboratory of Veterinary Pharmacokinetics and Pharmacodynamics, College of Veterinary Medicine, Kyungpook National University, Daegu, 702 701, Republic of Korea
J Anim Sci 88:3880-6. 2010..CT), a diet containing anti-Salmonella Typhimurium bacteriophage, 3 × 10(9) plaque-forming units/kg of feed (ASB), Lactobacillus plantarum CJLP56, 6.5 × 10(8) cfu/kg of feed (LP), 0...
- Direct transfer of starter substrates from type I fatty acid synthase to type III polyketide synthases in phenolic lipid synthesisAkimasa Miyanaga
Department of Biotechnology, Graduate School of Agriculture and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
Proc Natl Acad Sci U S A 105:871-6. 2008..vinelandii are synthesized by two type III polyketide synthases (PKSs), ArsB and ArsC, which are encoded by the ars operon...
- Outcomes of minimally invasive endoscopic resection of anterior skull base neoplasmsPete S Batra
Comprehensive Skull Base Program and Department of Otolaryngology Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Laryngoscope 120:9-16. 2010The objective of this study was to review clinical outcomes of minimally invasive endoscopic resection (MIER) for anterior skull base (ASB) neoplasms.
- Improved high-performance liquid chromatographic method for N-acetylgalactosamine-4-sulfate sulfatase (arylsulfatase B) activity determination using uridine diphospho-N-acetylgalactosamine-4-sulfateA J Leznicki
Department of Biochemistry, Nicholas Copernicus University, Torun, Poland
J Chromatogr B Biomed Sci Appl 696:193-202. 1997..was isolated from hen oviduct (isthmus) with a yield of 31 mumol per 100 g of wet tissue and used for arylsulfatase B (ASB) activity determination...
- Targeted disruption of the arylsulfatase B gene results in mice resembling the phenotype of mucopolysaccharidosis VIM Evers
Abteilung Biochemie II, Universitat Gottingen, Germany
Proc Natl Acad Sci U S A 93:8214-9. 1996..VI) is a lysosomal storage disease with autosomal recessive inheritance caused by a deficiency of the enzyme arylsulfatase B (ASB), which is involved in degradation of dermatan sulfate and chondroitin 4-sulfate...
- Bicistronic lentiviral vector corrects beta-hexosaminidase deficiency in transduced and cross-corrected human Sandhoff fibroblastsAudrey Arfi
Laboratoire de Genetique, Institut Cochin Université René Descartes Paris 5, INSERM U567, CNRS UMR 8104, 24 rue du Faubourg St Jacques, 75014 Paris, France
Neurobiol Dis 20:583-93. 2005..The bicistronic SIV.ASB vector enabled a massive restoration of beta-hexosaminidases activity on synthetic substrates and a 20% correction ..
- Toxicological responses in Laeonereis acuta (annelida, polychaeta) after arsenic exposureJuliane Ventura-Lima
Departamento de Ciencias Fisiologicas, Fundação Universidade Federal do Rio Grande FURG, Rio Grande, RS, Brazil
Environ Int 33:559-64. 2007..a limited accumulation of related methylated As species and the levels of non-toxic As species like arsenobetaine (AsB) and arsenocholine (AsC) remained unchanged during the exposure period when compared with the controls...
- Regulation and expression of the arsenic resistance operon from Staphylococcus aureus plasmid pI258G Ji
Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago 60680
J Bacteriol 174:3684-94. 1992..The DNA sequence contains three genes in the order arsR, arsB, and arsC...
- Cytokines in urine in elderly subjects with acute cystitis and asymptomatic bacteriuriaNils Rodhe
Centre for Clinical Research, Dalarna, Sweden
Scand J Prim Health Care 27:74-9. 2009Searching for useful diagnostic tools to discriminate between asymptomatic bacteriuria (ASB) and acute cystitis, this study compared urinary levels of cytokines/chemokines and leukocyte esterase in three groups of elderly subjects; those ..
- Anti-IL5 decreases the number of eosinophils but not the severity of dermatitis in Sharpin-deficient miceMatthew L Renninger
Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA
Exp Dermatol 19:252-8. 2010..Skin homogenates from mice treated with anti-IL5 had decreased mRNA expression of arylsulfatase B (Arsb), diamine oxidase (amiloride-binding protein 1, also called histaminase; Abp1) and Il10, which are ..
- Electronic memorandum decreases unnecessary antimicrobial use for asymptomatic bacteriuria and culture-negative pyuriaLeslie A Linares
Veterans Affairs Boston Health Care System, Boston, Massachusetts 02132, USA
Infect Control Hosp Epidemiol 32:644-8. 2011Asymptomatic bacteriuria/candidiuria (ASB) and culture-negative pyuria (CNP) are common and often result in inappropriate antibiotic use...
- Enhanced resolution of glycosylphosphatidylinositol-anchored and transmembrane proteins from the lipid-rich myelin membrane by two-dimensional gel electrophoresisChristopher M Taylor
Department of Neuroscience, MC 3401, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3401, USA
Proteomics 3:1303-12. 2003..We have identified two detergents, the nonionic n-dodecyl beta-D-maltoside and the zwitterionic amidosulfobetaine ASB-14, that are more effective in solubilizing myelin proteins than the commonly used zwitterionic detergent 3-[(3-..
- Molecular cloning and characterization of the human ASB-8 gene encoding a novel member of ankyrin repeat and SOCS box containing protein familyYongzhong Liu
State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032, PR China
Biochem Biophys Res Commun 300:972-9. 2003We have cloned a new member of human ankyrin repeat and SOCS box containing protein family (ASB), designed as hASB-8, from a human placental cDNA library and further extended by 5(') and 3(')-RACE...
- Combining the clinical signs improves diagnosis of scaphoid fractures. A prospective study with follow-upJ Parvizi
Department of Orthopaedics, Newcastle General Hospital, UK
J Hand Surg Br 23:324-7. 1998..scaphoid fracture were examined on two separate occasions to evaluate tenderness in the anatomical snuff box (ASB), tenderness over the scaphoid tubercle (ST), pain on longitudinal compression of the thumb (LC) and the range of ..
- Effect of alkaline-stabilized biosolids on alfalfa molybdenum and copper contentRichard C Stehouwer
Department of Crop and Soil Sciences, The Pennsylvania State University, University Park, PA 16802 3504, USA
J Environ Qual 33:133-40. 2004..Alkaline-stabilized biosolids (ASB) must be given particular consideration in assessment of Mo risk because the high pH of these biosolids could ..
- The influence of posterior capsular opacification removal on anterior segment birefringence parameters as measured by scanning laser polarimetryJose J Garcia-Medina
Ophthalmology Research Unit Santiago Grisolia, Department of Ophthalmology, Doctor Peset University Hospital, Valencia, Spain
Clin Exp Ophthalmol 35:414-20. 2007To determine the effect of posterior capsular opacification (PCO) removal on anterior segment birefringence (ASB) and its influence on peripapillary retinal nerve fibre layer (RNFL) retardation measurements obtained by means of scanning ..
- Expression of murine Asb-9 during mouse spermatogenesisMan Ryul Lee
Department of Anatomy and Cell Biology, Hanyang University, College of Medicine, Seoul 133 791, Korea
Mol Cells 26:621-4. 2008We previously showed that Asb-4 and Asb-17 is uniquely expressed in developing male germ cells...
- Expression of ankyrin repeat and suppressor of cytokine signaling box protein 4 (Asb-4) in proopiomelanocortin neurons of the arcuate nucleus of mice produces a hyperphagic, lean phenotypeJi Yao Li
Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
Endocrinology 151:134-42. 2010Ankyrin repeat and suppressor of cytokine signaling box-containing protein 4 (Asb-4) is specifically expressed in the energy homeostasis-related brain areas and colocalizes with proopiomelanocortin (POMC) neurons of the arcuate nucleus (..
- Endoscopic reconstruction of frontal, cribiform and ethmoid skull base defectsDavid Chin
University of New South Wales, Macquarie University, St Vincent s Hospital, Sydney, Australia
Adv Otorhinolaryngol 74:104-18. 2013..skull base reconstruction (ESBR) is an established option for complete reconstruction of the anterior skull base (ASB)...
- Phosphorylation of serine 323 of ASB2α is pivotal for the targeting of filamin A to degradationRim Zakaria
CNRS IPBS Institut de Pharmacologie et de Biologie Structurale, 205 route de Narbonne BP 64182, F 31077 Toulouse, France Université de Toulouse, UPS, IPBS, F 31077 Toulouse, France
Cell Signal 25:2823-30. 2013b>ASB proteins are the specificity subunits of cullin5-RING E3 ubiquitin ligases (CRL5) that play roles in ubiquitin-mediated protein degradation. However, how their activity is regulated remains poorly understood...
- Epidemiology and clinical outcomes of patients with carbapenem-resistant Klebsiella pneumoniae bacteriuriaZubair A Qureshi
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Antimicrob Agents Chemother 58:3100-4. 2014..Patients with positive urine cultures for CRKP were classified as having asymptomatic bacteriuria (ASB) or symptomatic urinary tract infection (UTI)...
- G-quadruplexes in viruses: function and potential therapeutic applicationsMathieu Metifiot
CNRS UMR 5234, Universite de Bordeaux, 146 rue Leo Saignat, 33076 Bordeaux, France
Nucleic Acids Res 42:12352-66. 2014G-rich nucleic acids can form non-canonical G-quadruplex structures (G4s) in which four guanines fold in a planar arrangement through Hoogsteen hydrogen bonds...
- Multiple Forms and Settings of Exposure to Violence and Values: Unique and Interactive Relationships With Antisocial Behavior in AdolescenceDario Bacchini
Second University of Naples, Caserta, Italy
J Interpers Violence 30:3065-88. 2015..multiple forms and settings of exposure to violence (ETV) as well as personal values and antisocial behavior (ASB) in adolescence...
- Conformational transition of a hairpin structure to G-quadruplex within the WNT1 gene promoterMargaret Hsin Jui Kuo
Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 106, Taiwan, R O C
J Am Chem Soc 137:210-8. 2015The role of G-quadruplexes (G4s) in biological systems has been widely studied. It is found that they have an important function in gene transcription and regulation...
- Differential antigenic protein recovery from Taenia solium cyst tissues using several detergentsJosé Navarrete-Perea
Department of Immunology, Institute for Biomedical Research, Universidad Nacional Autonoma de Mexico, Mexico D F 04510, Mexico
Mol Biochem Parasitol 202:22-8. 2015..Here, we describe the use of CHAPS, ASB-14 and Triton X-100, alone or in combination in the extraction buffers, as a strategy to notably increase the ..
- Novel mutations of the arylsulphatase B (ARSB) gene in Indian patients with mucopolysaccharidosis type VIAnusha Uttarilli
Diagnostics Division, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
Indian J Med Res 142:414-25. 2015..enzymatic activity of N-acetyl galactosamine-4-sulphatase resulting from mutations in the arylsulphatase B (ARSB) gene. The ARSB gene is located on chromosome 5q11-q13 and is composed of eight exons...
- Identification of the membrane component of the anion pump encoded by the arsenical resistance operon of R-factor R773M J San Francisco
Department of Biochemistry, Wayne State University School of Medicine, Detroit, Michigan 48201
Mol Microbiol 3:15-21. 1989..There are three structural genes, of which the product of the middle gene, arsB, has not previously been identified...
- Different susceptibility to lung tumorigenesis in mice with an identical Kras2 intron 2G Manenti
Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy
Genomics 29:438-44. 1995..analysis to map pulmonary adenoma susceptibility (Pas) loci in an urethane-treated (A/J x Mus spretus) x C57BL/6J (ASB) interspecific testcross...
- Gender and outpatient mental health service useAnne E Rhodes
Department of Psychiatry, University of Toronto, Canada
Soc Sci Med 54:1-10. 2002..as: a Mood and/or Anxiety Disorder (Mood/Anx) or a Substance Use Disorder and/or Antisocial Behaviours (Subs/Asb) within the past year. Use was defined in relation to providers seen within the past year...
- Isolation and characterization of arsenate-reducing bacteria from arsenic-contaminated sites in New ZealandCraig R Anderson
Department of Microbiology, Otago School of Medical Sciences, University of Otago, P O Box 56, Dunedin, New Zealand
Curr Microbiol 48:341-7. 2004..Strain WK6 was positive for arsB, but the pathway of arsenate reduction for isolate CA1 was via a hitherto unknown mechanism...
- Global analysis of cellular factors and responses involved in Pseudomonas aeruginosa resistance to arseniteKislay Parvatiyar
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, OH 45267 0524, USA
J Bacteriol 187:4853-64. 2005..Mutants lacking the As(III) translocator (ArsB), superoxide dismutase (SOD), catabolite repression control protein (Crc), or glutathione reductase (Gor) were more ..
- Francisella tularensis proteome: low levels of ASB-14 facilitate the visualization of membrane proteins in total protein extractsSusan M Twine
Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada
J Proteome Res 4:1848-54. 2005..5% amidosulfobetaine-14 (ASB-14) and 4% 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS)...
- Identification of differentially expressed genes in senescence-accelerated mouse testes by suppression subtractive hybridization analysisTakuya Chiba
Department of Investigative Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852 8523, Japan
Mamm Genome 18:105-12. 2007..b>Asb-8, a member of ankyrin repeat-containing proteins, was abundantly expressed in the testes and downregulated in ..
- Strategies to recover proteins from ocular tissues for proteomicsNikhil Patel
Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA
Proteomics 8:1055-70. 2008..3 to 50.7 mug protein/mg for different ocular tissues, with the lens yielding the most protein. ASB-14 and Triton X-100 provided the best protein yields (n = 10) for anterior and posterior sclera...
- Construction of arsB and tetH mutants of the sulfur-oxidizing bacterium Acidithiobacillus caldus by marker exchangeLeonardo J van Zyl
Department of Microbiology, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa
Appl Environ Microbiol 74:5686-94. 2008..caldus were isolated. The functionality of the gene inactivation system was shown by the construction of A. caldus arsB and tetH mutants, and the effects of these mutations on cell growth in the presence of arsenic and by means of ..
- Simultaneous determination of epothilone D and its hydrolytic metabolite in human plasma by high performance liquid chromatography-tandem mass spectrometry for pharmacokinetic studiesChunling Zhang
Laboratory of Drug Metabolism and Pharmacokinetics, Beijing Institute of Transfusion Medicine, 27 Taiping Road, Beijing 100850, China
J Chromatogr B Analyt Technol Biomed Life Sci 877:3748-52. 2009..Plasma samples were precipitated with acetonitrile, the analysis used a Venusil ASB C(18) analytical column...
- Complementary chromatography separation combined with hydride generation-inductively coupled plasma mass spectrometry for arsenic speciation in human urineLydia W L Chen
Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive, Edmonton, Alberta, Canada
Anal Chim Acta 675:71-5. 2010..However, the ion pair mode was unable to differentiate inorganic arsenite (As(III)) from arsenobetaine (AsB); instead, cation exchange chromatography was used to isolate and quantify AsB...
- [New possibilities in emergency medical transportation and emergency services of Polish Medical Air Rescue]Robert Gałazkowski
Lotnicze Pogotowie Ratunkowe, Zakład Medycyny Ratunkowej, Warszawski Uniwersytet Medyczny
Anestezjol Intens Ter 42:174-8. 2010..Transport ventilators can work in a variety of ventilation modes including CMV, SIMV, SVV, BILEVEL, PCV, ASB, PPV and CPAP...
- Determination of arsenobetaine in fish tissue by species specific isotope dilution LC-LTQ-Orbitrap-MS and standard addition LC-ICPMSLu Yang
Institute for National Measurement Standard, National Research Council Canada, Ottawa, Ontario, Canada
Anal Chem 83:3371-8. 2011An accurate and precise method for the determination of arsenobetaine (AsB, (CH(3))(3)(+)AsCH(2)COO(-)) in fish samples using exact matching species specific isotope dilution (ID) liquid chromatography LTQ-Orbitrap mass spectrometry (LC-..
- Transcriptional analysis of antibiotic resistance and virulence genes in multiresistant hospital-acquired MRSAMireille Pruneau
Departement de Biologie, Centre d étude et de valorisation de la diversité microbienne, Faculte des Sciences, Universite de Sherbrooke, QC, Canada
FEMS Immunol Med Microbiol 63:54-64. 2011..Genes encoding efflux pumps (norA, arsB, emrB) and the macrolide resistance gene ermA were found to be commonly expressed by HA-MRSA strains, but not in ..
- [Effectiveness comparison of anatomical single-bundle and over-the-top single-bundle reconstruction of anterior cruciate ligament]Yu Dong
Sports Medicine Center, Department of Sports Medicine and Arthroscopy Surgery of Huashan Hospital, Fudan University, Shanghai 200040, PR China
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 25:912-5. 2011To compare the effectiveness of anatomical single-bundle (ASB) and over-the-top single-bundle (OSB) reconstruction of the anterior cruciate ligament (ACL).
- Neonatal gene therapy with a gamma retroviral vector in mucopolysaccharidosis VI catsKatherine P Ponder
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Mol Ther 20:898-907. 2012..MPS) VI is due to a deficiency in the activity of N-acetylgalactosamine 4-sulfatase (4S), also known as arylsulfatase B. Previously, retroviral vector (RV)-mediated neonatal gene therapy reduced the clinical manifestations of MPS ..
- Celebrating the golden anniversary of anterior skull base surgery: reflections on the past 50 years and its historical evolutionQasim Husain
Department of Otolaryngology Head and Neck Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
Laryngoscope 123:64-72. 2013..inception nearly half a century ago through the pioneering work of Dandy, McLean, and Smith, anterior skull base (ASB) surgery is a relatively young discipline...
- Arylsulfatase B improves locomotor function after mouse spinal cord injuryMyungsik Yoo
W M Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, United States of America
PLoS ONE 8:e57415. 2013..We hypothesized that the mammalian enzyme arylsulfatase B (ARSB) would also enhance recovery after mouse spinal cord injury...
- Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variantsLi Yang
Peking University Sixth Hospital Institute of Mental Health, Beijing, China
Am J Med Genet B Neuropsychiatr Genet 162:419-30. 2013..Some common causal variants are likely to be shared between Han Chinese and Caucasians. Complex neurodevelopmental networks may underlie ADHD's etiology...
- Liquid chromatography-tandem mass spectrometry simultaneous determination of repaglinide and metformin in human plasma and its application to bioequivalence studyXiao Rong Liang
Zhejiang University of Technology, Hangzhou 310014, China
Yao Xue Xue Bao 48:547-53. 2013..precipitation using acetonitrile as the precipitation solvent, both analytes and ISs were separated on a Venusil ASB C 18 (150 mm x 4...
- Rapid impact of phenanthrene and arsenic on bacterial community structure and activities in sand batchesA Cébron
LIEC UMR7360, CNRS Université de Lorraine, Faculté des Sciences et Technologies, BP 70239, 54506, Vandoeuvre les Nancy Cedex, France
Microb Ecol 67:129-44. 2014..transcripts revealed that arsenic induced the transcription of functional arsenic resistance and speciation genes (arsB, ACR3 and aioA), while no transcription of PAH-degradation genes (PAH-dioxygenase and catechol-dioxygenase) was ..
- Attenuated osteoarticular phenotype of type VI mucopolysaccharidosis: a report of four patients and a review of the literatureAgnieszka Jurecka
Department of Medical Genetics, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730, Warsaw, Poland
Clin Rheumatol 33:725-31. 2014..OMIM 253200) is caused by mutations in the gene coding for N-acetylgalactosamine-4-sulfatase (4-sulfatase, arylsulfatase B, ARSB, EC 22.214.171.124), a lysosomal enzyme involved in the degradation of dermatan sulfate (DS)...
- Sensory-motor behavioral characterization of an animal model of Maroteaux-Lamy syndrome (or Mucopolysaccharidosis VI)Paola Saccone
1 Telethon Institute of Genetics and Medicine TIGEM, Naples, Italy 2 Institute of Genetics and Biophysics, CNR, Naples, Italy 3
Sci Rep 4:3644. 2014Maroteaux-Lamy disease, also known as mucopolysaccharidosis (MPS) VI, is an MPS disorder caused by mutations in the ARSB gene encoding for the lysosomal enzyme arysulfatase B (ARSB)...
- Metagenomic approach reveals variation of microbes with arsenic and antimony metabolism genes from highly contaminated soilJinming Luo
Key Laboratory of Drinking Water Science and Technology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, People s Republic of China University of Chinese Academy of Sciences, Beijing, People s Republic of China
PLoS ONE 9:e108185. 2014..The distribution, diversity and abundance of functional genes (including arsC, arrA, aioA, arsB and ACR3) were much higher for the samples containing higher As and Sb concentrations...
- Childhood EEG frontal alpha power as a predictor of adolescent antisocial behavior: a twin heritability studySharon Niv
Department of Psychology, University of Southern California, United States Electronic address
Biol Psychol 105:72-6. 2015..to represent a state of low arousal in the brain, which has been related in past research to antisocial behavior (ASB)...
- Comparison of Type 1 D-3-phosphoglycerate dehydrogenases reveals unique regulation in pathogenic MycobacteriaXiao Lan Xu
Department of Developmental Biology, Washington University School of Medicine, 660 S Euclid Avenue, Box 8103, St Louis, MO 63110, United States
Arch Biochem Biophys 570:32-9. 2015..the properties of Type 1 PGDHs from seven different species and demonstrates that conserved residues in the ACT and ASB domains of some allow l-serine to act as a feedback inhibitor at low micromolar concentrations...
- Reversed Phase Column HPLC-ICP-MS Conditions for Arsenic Speciation Analysis of Rice FlourTomohiro Narukawa
National Metrology Institute of Japan NMIJ, National Institute of Advanced Industrial Science and Technology AIST
Anal Sci 31:521-7. 2015..acid (MMAA), dimethylarsinic acid (DMAA), trimethylarsine oxide (TMAO), tetramethylarsonium (TeMA), arsenobetaine (AsB) and arsenocholine (AsC), were separated and determined under the proposed conditions...
- Asymptomatic Bacteriuria & Risk of Urinary Tract Infection in Renal TransplantsJAMES CARTER RICE; Fiscal Year: 2010Asymptomatic bacteriuria (ASB) is the isolation of a specified quantity of bacteria from a person without symptoms or signs referableto urinary infection. ASB is common in women and increases with advancing age...
- Post-translational regulation of MLL in leukemogenesisANDREW GEORGE MUNTEAN; Fiscal Year: 2012..An expression analysis of the ASB family during hematopoietic development will be performed to test whether ASB proteins degrade MLL protein in ..
- ANDREW GEORGE MUNTEAN; Fiscal Year: 2014..An expression analysis of the ASB family during hematopoietic development will be performed to test whether ASB proteins degrade MLL protein in ..
- Rembert Pieper; Fiscal Year: 2016..colonization of long term-inserted urethral catheters results in CA-UTI versus asymptomatic bacteriuria (CA-ASB) are essentially not known, and causative factors pertaining to the host environment and complexity of microbial ..
- Development, Implementation and Evaluation of Novel Strategies to Reduce InappropCURTIS DONSKEY; Fiscal Year: 2010..care settings because they are common and because treatment is often prescribed for asymptomatic bacteriuria (ASB), for which therapy is not indicated...
- Development of Externalizing Behavior Problems: Gene-Environment InterplayLaura A Baker; Fiscal Year: 2013..study is a continuation into adulthood of a major longitudinal twin study of aggression and antisocial behavior (ASB) and its social and biological risk factors (#MH58354) in a diverse urban sample...
- Cranberry for Prevention of Bacteriuria in PregnancyDeborah Wing; Fiscal Year: 2005..Colonization of the urinary bladder, known as asymptomatic bacteriuria (ASB), often precedes the development of symptomatic urinary tract infections...
- FACTORS PREDISPOSING TO URINARY TRACT INFECTIOUSWalter Stamm; Fiscal Year: 1993..spermicide alone with 300 new oral contraceptive users to determine the relative risk of asymptomatic bacteriuria (ASB) and symptomatic UTI in the first two groups...
- Notch-induced protein degradation in lymphopoiesisXiao Hong Sun; Fiscal Year: 2013..that Notch signaling stimulates the transcription of a family of ankyrin repeats and SOCS box containing proteins (Asb), which can promote the degradation of proteins targeted by Notch...
- Obesity is a Surgical ProblemMichael W Mulholland; Fiscal Year: 2013..analysis of hypothalamic gene expression changes has identified ankyrin repeat and SOCS box containing protein 4 (Asb-4) as a very promising investigative target...
- Hongkai Ji; Fiscal Year: 2014..Third, a method for detecting allele-specific protein-DNA binding (ASB) will be developed...
- OLIGOSACCHARIDE STRUCTURE &FUNCTION IN RECOGNITIONJacques U Baenziger; Fiscal Year: 2012..We have demonstrated by biochemical and genetic means that the Mannose/GalNAc-4-SO4-receptor (M/G4S-R) and the asialoglycoprotein-receptor (ASGP-R) mediate the respective clearance of glycoproteins that bear the N-..
- Deconvoluting G-quadruplex and i-Motif dynamics: the role of the physiological stRandy M Wadkins; Fiscal Year: 2013..aims: 1) Quantify the kinetic and thermodynamic properties, nucleotide interactions, and underlying equilibrating G4s/iM structures in the presence of 5-hydroxymethylated cytosines and 2) Determine structural equilibria and protein-..
- Sugar-sweetened beverages and cardiovascular disease risk: an RCTDavid S Ludwig; Fiscal Year: 2013..rising public health awareness of these potential adverse effects, consumption of artificially sweetened beverages (ASB) has increased dramatically...
- 1st International Thumb Osteoarthritis Workshop (ITOW)Joseph J Crisco; Fiscal Year: 2013..aspects of CMC OA may be covered at other specialty meetings (such as the American Society of Biomechanics [ASB], the Orthopaedic Research Society [ORS], the Osteoarthritis Research Society International [OARSI], and the ..
- BIOCHEMICAL BASIS OF SULFATASE ACTIVITYALLEN HORWITZ; Fiscal Year: 1992..Antibody and cDNA probes for steroid sulfatase, iduronate sulfatase (Id-S) and arylsulfatase B (ASB) will be used to study the various levels of control of study the molecular basis of the genetic ..
- AIDS-related Animal Services Building Cage Washing FacilityM Smith; Fiscal Year: 2007..requests funds to renovate the old cage washing facility in the original part of the Animal Services Building (ASB) complex that houses nonhuman primates (NHPs)...
- FASEB SUMMER CONFERENCE ON PHOSPHOLIPASESAndrew Morris; Fiscal Year: 2004..This will be the seventh ASB conference on this subject...
- ASB1 Containment ExpansionDANIEL MICHAEL DORSA; Fiscal Year: 2011..This project proposes to construct an addition to the Animal Services Building (ASB) bio-containment space that will add six animal rooms and a kitchen...
- TRANSPORT ATPASE--ENERGY COUPLINGParjit Kaur; Fiscal Year: 1999..It consists of an integral membrane protein ArsB that functions as a carrier, and a peripheral membrane protein ArsA that forms the catalytic subunit...
- OLIGOSACCHARIDE STRUCTURE AND FUNCTION IN RECOGNITIONJACQUES BAENZIGER; Fiscal Year: 2007..We previously defined how the Mannose/GalNAc-4-SO4-receptor (M/G4S-R) mediates the clearance of glycoproteins that bear the N-linked oligosaccharide signature of terminal GalNAc-4-..
- STRUCTURE/FUNCTION OF AN ION MOTIVE ATPASEDOMENICO GATTI; Fiscal Year: 2001..The arsA and the arsB genes o the operon encode, respectively, the catalytic subunit (ATPase) and the membrane subunit of the pump...
- Barry P Rosen; Fiscal Year: 2016..The ars operon codes for two regulatory (ArsR and ArsD) and three structural (ArsA, ArsB and ArsC) proteins. Resistance correlates with active extrusion of arsenite from the cell by a primary pump...
- Nonhuman Primate Primary Housing Units for Animal Services Building 3M Smith; Fiscal Year: 2006..ASB3 is the third addition to the original ASB and will add an additional 900 housing spaces for NHPs in cages and small group housing units...
- ANTISOCIAL BEHAVIORS IN US AND ISLAND PUERTO RICAN YOUTHHector Bird; Fiscal Year: 2004..compares the development, the comorbidities and the risk factors of disruptive disorders and antisocial behaviors (ASB) in Puerto Rican children and adolescents in Puerto Rico (P.R.) and the mainland U.S...
- Meta-Analysis of Risk for Antisocial BehaviorMARK LIPSEY; Fiscal Year: 2003APPLICANT?S DESCRIPTION: This research concerns antisocial behavior (ASB), i.e., intentional behavior that harms or threatens other persons or their property...
- 2004 Annual Meeting: American Society of BiomechanicsMichael Bottlang; Fiscal Year: 2004Partial support is requested for the 28th annual meeting of the American Society of Biomechanics (ASB), hosted in Portland, Oregon from September 9th- 1lth, 2004...
- EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONPETER KOHLER; Fiscal Year: 2002This application requests funds to construct Phase II infill to the Animal Services Building (ASB) addition that will provide housing for 544 non-human primates (NHPs) in an 11,970 sq. ft. state-of-the art facility...
- Support for ASB Conference 2009 at Penn State UniversityJohn Challis; Fiscal Year: 2009..The annual conference this year will be held at the Pennsylvania State University on August 26-29, 2009. This application requests funds to reduce the registration fees of female and/or minority students. ..
- SUBSTRATE RECOGNITION IN MULTIDRUG RESISTANCEBarry Rosen; Fiscal Year: 1993..Two of the structural genes, the arsA and arsB genes, encode the two subunits of the pump...
- Using CBPR to Design & Pilot a Physical Activity Program for Youth with ASBRichard Fleming; Fiscal Year: 2009..Community-Based Participatory Research (CBPR) is ideally suited to such an endeavor, particularly in the ways it can facilitate involvement of families of children with ASD. ..
- Clinical Investigation of E.coli Biofilm Formation in the Human BladderBARBARA TRAUTNER; Fiscal Year: 2007..No effective strategy exists to prevent CAUTI in persons who require ongoing catheter use. Identifying genes that are required to cause CAUTI will lead to new strategies to prevent this illness. [unreadable] [unreadable] [unreadable]..
- Treatment and/or Prevention of Urinary Tract InfectionsBARBARA TRAUTNER; Fiscal Year: 2008..An agent to prevent and treat UTI that does not encourage microbial resistance would have a significant impact on public health. [unreadable] [unreadable] [unreadable]..
- E. coli for prevention of Catheter UTI in SCI PatientsBARBARA TRAUTNER; Fiscal Year: 2006..The candidate plans to combine her clinical background in infectious diseases with the mentored research preformed under this award in order to reduce the secondary infectious complications of mobility disorders. ..
- TETHERED DOMAINS AS REGULATORY ELEMENTSGregory Grant; Fiscal Year: 2009..Our observations that PGDH from M. tuberculosis is inhibited by L-serine and that PGDH from humans is not, may provide a new focus in drug development for treatment of tuberculosis. ..
- HPA Axis Function in Adolescent Antisocial FemalesKathleen Pajer; Fiscal Year: 2007..abstract_text> ..
- PATHOGENESIS OF DISEASE IN MUCOPOLYSACCHARIDOSIS I AND VIIKatherine P Ponder; Fiscal Year: 2010..These studies may demonstrate that the development of disease in the aorta and the cervical spine in MPS is due to a common mechanism, and may identify a therapy for these difficult-to-treat sites. ..
- TLR5 and Pulmonary Innate ImmunityTHOMAS HAWN; Fiscal Year: 2009..The immunogenetic models derived from these studies will illuminate the molecular basis of why individuals have different susceptibility to flagellated bacterial infections and hopefully culminate in novel insights for future therapies. ..
- Lysosomal Disease Network-4th Annual WORLD SymposiumChester Whitley; Fiscal Year: 2008..The WORLD Symposium brings together researchers, physicians and patient advocates to advance medical science and public policy for such desperate problems. [unreadable] [unreadable] [unreadable]..
- Clinical Features in Nursing Home Residents with Suspected UTIManisha Juthani Mehta; Fiscal Year: 2008..This study will create an evidence-based definition of UTI. Future studies will identify residents with UTI in whom antibiotic therapy improves clinical outcome. [unreadable] [unreadable] [unreadable]..
- Lysosomal Disease Network-3rd Annual WORLD SymposiumChester Whitley; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Regulation of BER Gene Expression by Folate DeficiencyDIANE CABELOF; Fiscal Year: 2006..The loss of the BER response to DNA damage when folate is deficient would establish a mechanism by which diet can alter susceptibility to environmental exposure. [unreadable] [unreadable] [unreadable]..
- IMPROVED METHODS FOR IN VIVO HEPATIC GENE THERAPYKATHERINE PONDER; Fiscal Year: 2006..Success in this project might lead to a safe, effective, and permanent therapy for genetic deficiencies that involve proteins synthesized by the liver. ..
- Transdisciplinary Imaging Genetics Center (1 of 2)(RMI)Steven Potkin; Fiscal Year: 2006..The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness. [unreadable] [unreadable]..
- Lysosomal Disease Network-2nd Annual WORLD SymposiumChester Whitley; Fiscal Year: 2005..Sessions for patients and patient advocates will include educational presentations, support services, and round table discussions ..
- GENE THERAPY FOR BLOOD PROTEIN DEFICIENCIESKATHERINE PONDER; Fiscal Year: 2005..Success in this project might lead to a safe, effective, and permanent therapy for Hemophilia B. ..
- Structure of Microsomal Enzymes in Estrogen BiosynthesisDebashis Ghosh; Fiscal Year: 2005....
- Bacterial Cell Surfaces Gordon ConferenceBarry Rosen; Fiscal Year: 2004..abstract_text> ..
- MOLECULAR GENETICS OF CHILDHOOD DISRUPTIVE DISORDERSIrwin Waldman; Fiscal Year: 2004..The proposed study will increase substantially our understanding of specific genetic influences on the childhood disruptive disorders. ..
- Functional Organization of the Myelin MembraneChristopher Taylor; Fiscal Year: 2003..in forming rafts in myelin, 3) provide a more complete understanding of the organization of proteins and lipids in myelin as well as identify potential targets for the therapeutic intervention in many myelin related disorders/diseases ..
- Toll-like Receptors and the Innate Immune ResponseTHOMAS HAWN; Fiscal Year: 2003..tuberculosis and L. major will reveal novel insights about innate immunity and infectious diseases that will have implications for vaccine development. ..