ARSB

Summary

Gene Symbol: ARSB
Description: arylsulfatase B
Alias: ASB, G4S, MPS6, arylsulfatase B, N-acetylgalactosamine-4-sulfatase
Species: human

Top Publications

  1. ncbi Structure of a human lysosomal sulfatase
    C S Bond
    Department of Biochemistry, University of Sydney, NSW 2006 Australia
    Structure 5:277-89. 1997
  2. doi Maroteaux-Lamy syndrome: functional characterization of pathogenic mutations and polymorphisms in the arylsulfatase B gene
    Elena Garrido
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Mol Genet Metab 94:305-12. 2008
  3. doi Arylsulfatase B regulates colonic epithelial cell migration by effects on MMP9 expression and RhoA activation
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Clin Exp Metastasis 26:535-45. 2009
  4. doi Cell-bound IL-8 increases in bronchial epithelial cells after arylsulfatase B silencing due to sequestration with chondroitin-4-sulfate
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois at Chicago, 840 S Wood Street, Chicago, IL 60612, USA
    Am J Respir Cell Mol Biol 42:51-61. 2010
  5. pmc Extra-lysosomal localization of arylsulfatase B in human colonic epithelium
    Sanjiv V Prabhu
    Department of Pathology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Histochem Cytochem 59:328-35. 2011
  6. pmc Hypoxia reduces arylsulfatase B activity and silencing arylsulfatase B replicates and mediates the effects of hypoxia
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e33250. 2012
  7. ncbi Increased arylsulfatase B activity in cystic fibrosis cells following correction of CFTR
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois at Chicago and Jesse Brown VAMC, Chicago, IL 60612, USA
    Clin Chim Acta 380:122-7. 2007
  8. doi Distinct effects of N-acetylgalactosamine-4-sulfatase and galactose-6-sulfatase expression on chondroitin sulfates
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Biol Chem 283:9523-30. 2008
  9. pmc Mucopolysaccharidosis VI
    Vassili Valayannopoulos
    Reference Center for Inherited Metabolic Diseases, Necker Enfants Malades Hospital, Paris, France
    Orphanet J Rare Dis 5:5. 2010
  10. doi Arylsulfatase B regulates interaction of chondroitin-4-sulfate and kininogen in renal epithelial cells
    Sumit Bhattacharyya
    University of Illinois at Chicago, Chicago, IL 60612, USA
    Biochim Biophys Acta 1802:472-7. 2010

Research Grants

  1. Asymptomatic Bacteriuria & Risk of Urinary Tract Infection in Renal Transplants
    JAMES CARTER RICE; Fiscal Year: 2010
  2. Post-translational regulation of MLL in leukemogenesis
    ANDREW GEORGE MUNTEAN; Fiscal Year: 2012
  3. ANDREW GEORGE MUNTEAN; Fiscal Year: 2014
  4. Rembert Pieper; Fiscal Year: 2016
  5. Development, Implementation and Evaluation of Novel Strategies to Reduce Inapprop
    CURTIS DONSKEY; Fiscal Year: 2010
  6. Development of Externalizing Behavior Problems: Gene-Environment Interplay
    Laura A Baker; Fiscal Year: 2013
  7. Cranberry for Prevention of Bacteriuria in Pregnancy
    Deborah Wing; Fiscal Year: 2005
  8. FACTORS PREDISPOSING TO URINARY TRACT INFECTIOUS
    Walter Stamm; Fiscal Year: 1993
  9. Notch-induced protein degradation in lymphopoiesis
    Xiao Hong Sun; Fiscal Year: 2013
  10. Obesity is a Surgical Problem
    Michael W Mulholland; Fiscal Year: 2013

Detail Information

Publications249 found, 100 shown here

  1. ncbi Structure of a human lysosomal sulfatase
    C S Bond
    Department of Biochemistry, University of Sydney, NSW 2006 Australia
    Structure 5:277-89. 1997
    ..To understand the catalytic mechanism of sulfatases, and ultimately the determinants of their substrate specificities, we have determined the structure of N-acetylgalactosamine-4-sulfatase...
  2. doi Maroteaux-Lamy syndrome: functional characterization of pathogenic mutations and polymorphisms in the arylsulfatase B gene
    Elena Garrido
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Mol Genet Metab 94:305-12. 2008
    ..syndrome) is an autosomal recessive lysosomal disorder caused by deficiency of N-acetylgalactosamine-4-sulfatase (ARSB), which is required for the degradation of dermatan sulfate...
  3. doi Arylsulfatase B regulates colonic epithelial cell migration by effects on MMP9 expression and RhoA activation
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Clin Exp Metastasis 26:535-45. 2009
    b>Arylsulfatase B (ASB; N-acetylgalactosamine-4-sulfatase; 4-sulfatase; ARSB) is the enzyme that removes 4-sulfate groups from N-acetylgalactosamine 4-sulfate, which combines with glucuronate to form the disaccharide unit of chondroitin-4-..
  4. doi Cell-bound IL-8 increases in bronchial epithelial cells after arylsulfatase B silencing due to sequestration with chondroitin-4-sulfate
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois at Chicago, 840 S Wood Street, Chicago, IL 60612, USA
    Am J Respir Cell Mol Biol 42:51-61. 2010
    ..C4S) in mediating effects of IL-8, we silenced the enzyme N-acetylgalactosamine-4-sulfatase (arylsulfatase B [ASB]) that removes the 4-sulfate group from C4S, in the IB3-1 and C38 bronchial epithelial cell lines and in ..
  5. pmc Extra-lysosomal localization of arylsulfatase B in human colonic epithelium
    Sanjiv V Prabhu
    Department of Pathology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Histochem Cytochem 59:328-35. 2011
    The enzyme arylsulfatase B (N-acetylgalactosamine-4-sulfatase; ARSB; ASB) removes 4-sulfate groups from the sulfated glycosaminoglycans (sGAG) chondroitin-4-sulfate (C4S) and dermatan sulfate (DS)...
  6. pmc Hypoxia reduces arylsulfatase B activity and silencing arylsulfatase B replicates and mediates the effects of hypoxia
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e33250. 2012
    This report presents evidence of 1) a role for arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) in mediating intracellular oxygen signaling; 2) replication between the effects of ARSB silencing and hypoxia on sulfated ..
  7. ncbi Increased arylsulfatase B activity in cystic fibrosis cells following correction of CFTR
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois at Chicago and Jesse Brown VAMC, Chicago, IL 60612, USA
    Clin Chim Acta 380:122-7. 2007
    ..Since the enzyme arylsulfatase B (ASB) catalyzes hydrolysis of the sulfate ester of N-acetylgalactosamine 4-sulfate, a component of dermatan ..
  8. doi Distinct effects of N-acetylgalactosamine-4-sulfatase and galactose-6-sulfatase expression on chondroitin sulfates
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Biol Chem 283:9523-30. 2008
    The sulfatase enzymes, N-acetylgalactosamine-4-sulfatase (arylsulfatase B (ASB)) and galactose-6-sulfatase (GALNS) hydrolyze sulfate groups of CS. Deficiencies of ASB and GALNS are associated with the mucopolysaccharidoses...
  9. pmc Mucopolysaccharidosis VI
    Vassili Valayannopoulos
    Reference Center for Inherited Metabolic Diseases, Necker Enfants Malades Hospital, Paris, France
    Orphanet J Rare Dis 5:5. 2010
    ..VI) is a lysosomal storage disease with progressive multisystem involvement, associated with a deficiency of arylsulfatase B leading to the accumulation of dermatan sulfate...
  10. doi Arylsulfatase B regulates interaction of chondroitin-4-sulfate and kininogen in renal epithelial cells
    Sumit Bhattacharyya
    University of Illinois at Chicago, Chicago, IL 60612, USA
    Biochim Biophys Acta 1802:472-7. 2010
    The enzyme arylsulfatase B (N-acetylgalactosamine 4-sulfatase; ASB; ARSB), which removes 4-sulfate groups from the nonreducing end of chondroitin-4-sulfate (C4S;CSA) and dermatan sulfate, has cellular effects, beyond those associated ..
  11. ncbi Arsenic metabolism in seaweed-eating sheep from Northern Scotland
    J Feldmann
    University of Aberdeen, Department of Chemistry, Scotland, UK
    Fresenius J Anal Chem 368:116-21. 2000
    ..DMAA), monomethylarsonic acid (MMAA), trimethylarsine oxide (TMAO), tetramethylarsonium ion (TMA), arsenobetaine (AsB), arsenocholine (AsC), dimethylarsinoyl ethanol (DMAE) and four common dimethylarsinoylribosides (arsenosugars)...
  12. ncbi Steroid sulfatase, arylsulfatases A and B, galactose-6-sulfatase, and iduronate sulfatase in mammary cells and effects of sulfated and non-sulfated estrogens on sulfatase activity
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States Jesse Brown VAMC, Chicago, IL, United States
    J Steroid Biochem Mol Biol 103:20-34. 2007
    ..enzymes, including steroid sulfatase (STS; arylsulfatase C), arylsulfatase A (ASA; cerebroside sulfatase), arylsulfatase B (ASB; N-acetylgalactosamine-4-sulfatase), galactose-6-sulfatase (GALNS), and iduronate-2-sulfatase (IDS), was ..
  13. doi Intrathecal administration of recombinant human N-acetylgalactosamine 4-sulfatase to a MPS VI patient with pachymeningitis cervicalis
    María Verónica Muñoz-Rojas
    Post Graduation Program in Child and Adolescent Health, UFRGS, Porto Alegre, RS, Brazil
    Mol Genet Metab 99:346-50. 2010
    ..We report the use of intrathecal (IT) recombinant human N-acetylgalactosamine 4-sulfatase (arylsulfatase B, or ASB) in a MPS VI child with spinal cord compression whose parents initially refused the surgical ..
  14. ncbi Long-term intra-articular administration of recombinant human N-acetylgalactosamine-4-sulfatase in feline mucopolysaccharidosis VI
    Dyane Auclair
    Lysosomal Diseases Research Unit, Department of Genetic Medicine, Children, Youth and Women s Health Service, SA, Australia
    Mol Genet Metab 91:352-61. 2007
    ..These data support the view that intra-articular therapy may be a good option for preventing the development of the severe articular pathology in MPS VI...
  15. ncbi Recombinant caprine 3H-[N-acetylglucosamine-6-sulfatase] and human 3H-[N-acetylgalactosamine-4-sulfatase]: plasma clearance, tissue distribution, and cellular uptake in the rat
    M Z Jones
    Department of Chemical Pathology, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    J Mol Neurosci 11:223-32. 1998
    ..The low level of enzyme recovered from the brain suggests that modification of rc6S will be necessary to achieve sufficient enzyme uptake into the CNS for effective therapy of MPS IIID...
  16. pmc Enzyme replacement therapy for mucopolysaccharidosis VI: evaluation of long-term pulmonary function in patients treated with recombinant human N-acetylgalactosamine 4-sulfatase
    Paul Harmatz
    Children s Hospital and Research Center Oakland, CA 94609, USA
    J Inherit Metab Dis 33:51-60. 2010
    ..function was studied in patients during long-term enzyme replacement therapy (ERT) with recombinant human arylsulfatase B (rhASB; rhN-acetylgalactosamine 4-sulfatase)...
  17. doi High-performance liquid chromatography-inductively coupled plasma mass spectrometry based method for the determination of organic arsenic feed additives and speciation of anionic arsenics in animal feed
    Peilong Wang
    Institute of Quality Standards and Testing Techniques for Agriculture Products, China Agricultural Academy of Science, Beijing, China
    J Agric Food Chem 58:5263-70. 2010
    ..chromatography coupled to tandem mass spectrometry (LC-MS/MS) was used as an assistant tool to screen arsenobetain (AsB) in the feed samples by monitoring the reaction at m/z 179-->120...
  18. ncbi Replacement therapy in Mucopolysaccharidosis type VI: advantages of early onset of therapy
    Dyane Auclair
    Lysosomal Diseases Research Unit, Department of Chemical Pathology, Women s and Children s Hospital, 72 King William Road, North Adelaide, SA 5006, Australia
    Mol Genet Metab 78:163-74. 2003
    ..Overall improvement in the disease condition (at physical, neurological, and skeletal levels) was most pronounced for cats treated from birth compared with cats treated at a later age...
  19. ncbi Enzyme replacement therapy for mucopolysaccharidosis VI: a phase 3, randomized, double-blind, placebo-controlled, multinational study of recombinant human N-acetylgalactosamine 4-sulfatase (recombinant human arylsulfatase B or rhASB) and follow-on, open-l
    Paul Harmatz
    Children s Hospital and Research Center at Oakland, California 94609, USA, and Children s Hospital, University of Mainz, Germany
    J Pediatr 148:533-539. 2006
    The objective of this Phase 3 study was to confirm the efficacy and safety of recombinant human arylsulfatase B (rhASB) treatment of mucopolysaccharidosis type VI (MPS VI; Maroteaux-Lamy syndrome), a rare, fatal lysosomal storage disease ..
  20. doi Long-term follow-up of endurance and safety outcomes during enzyme replacement therapy for mucopolysaccharidosis VI: Final results of three clinical studies of recombinant human N-acetylgalactosamine 4-sulfatase
    Paul Harmatz
    Children s Hospital and Research Center Oakland, 747 52nd Street, Oakland, CA 94609, USA
    Mol Genet Metab 94:469-75. 2008
    The objective of this study was to evaluate the long-term clinical benefits and safety of recombinant human arylsulfatase B (rhASB) treatment of mucopolysaccharidosis type VI (MPS VI: Maroteaux-Lamy syndrome), a lysosomal storage disease...
  21. doi Arsenic-resistant bacteria associated with roots of the wild Cirsium arvense (L.) plant from an arsenic polluted soil, and screening of potential plant growth-promoting characteristics
    Lucia Cavalca
    Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, Universita degli Studi di Milano, Via Celoria 2, Milano 20133, Italy
    Syst Appl Microbiol 33:154-64. 2010
    ..Most strains possessed the ArsC, ArsB and ACR3 genes homologous to arsenate reductase and to the two classes of arsenite efflux pumps, respectively, ..
  22. ncbi Characterization of iodothyronine sulfatase activities in human and rat liver and placenta
    Monique H A Kester
    Department of Internal Medicine, Erasmus University Medical School, 3000 DR Rotterdam, The Netherlands
    Endocrinology 143:814-9. 2002
    ..hydrolysis of iodothyronine sulfates by homogenates of V79 cells expressing the human arylsulfatases A (ARSA), B (ARSB), or C (ARSC; steroid sulfatase), as well as tissue fractions of human and rat liver and placenta...
  23. ncbi Arcuate nucleus transcriptome profiling identifies ankyrin repeat and suppressor of cytokine signalling box-containing protein 4 as a gene regulated by fasting in central nervous system feeding circuits
    J Y Li
    Department of Surgery, University of Michigan, Ann Arbor, 48109, USA
    J Neuroendocrinol 17:394-404. 2005
    ..One of the down-regulated mRNAs was ankyrin-repeat and suppressor of cytokine signalling box-containing protein 4 (Asb-4)...
  24. ncbi Altered mRNA abundance of ASB15 and four other genes in skeletal muscle following administration of beta-adrenergic receptor agonists
    Tara G McDaneld
    Department of Animal Sciences, Purdue University, West Lafayette 47907 2054, USA
    Physiol Genomics 16:275-83. 2004
    ..Changes in rat Asb-15 mRNA were measured at 30 min, 12 h, and 24 h following intraperitoneal injections of each compound...
  25. pmc Assessing the measurement precision of various arsenic forms and arsenic exposure in the National Human Exposure Assessment Survey (NHEXAS)
    Edo D Pellizzari
    RTI International, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 114:220-7. 2006
    ..arsenic, arsenate [As(V)], arsenite, dimethyl arsenic acid (DMA), monomethyl arsenic acid (MMA), arsenobetaine (AsB), and arsenocholine...
  26. pmc Chloroquine reduces arylsulphatase B activity and increases chondroitin-4-sulphate: implications for mechanisms of action and resistance
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois at Chicago, 840 S, Wood St, CSN 440 M C 718 Chicago, IL 60612, USA
    Malar J 8:303. 2009
    ..and alters normal lysosomal processes, the effects of chloroquine on the lysosomal enzyme arylsulphatase B (ASB, N-acetylgalactosamine-4-sulphatase), which removes 4-sulphate groups from chondroitin-4-sulphate, were addressed...
  27. pmc Clinical outcomes following hematopoietic stem cell transplantation for the treatment of mucopolysaccharidosis VI
    Sean Turbeville
    BioMarin Pharmaceutical Inc, 105 Digital Drive, Novato, CA 94949, USA
    Mol Genet Metab 102:111-5. 2011
    ..MPS VI is characterized by an absence or deficiency of N-acetylgalactosamine 4-sulfatase (arylsulfatase B) resulting in accumulation of dermatan sulfate...
  28. ncbi Enzyme replacement therapy in Mucopolysaccharidosis VI: evidence for immune responses and altered efficacy of treatment in animal models
    D A Brooks
    Department of Chemical Pathology, Women s and Children s Hospital, North Adelaide South Australia
    Biochim Biophys Acta 1361:203-16. 1997
    ..The development of high titre antibody may have a detrimental effect on the efficacy of ERT...
  29. ncbi Functional analysis of a chromosomal arsenic resistance operon in Pseudomonas fluorescens strain MSP3
    S Prithivirajsingh
    Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Mol Biol Rep 28:63-72. 2001
    ..Nucleotide sequencing revealed the presence of three open reading frames homologous to the arsR, arsB and arsC genes of arsenic resistance...
  30. ncbi Enzyme replacement therapy in mucopolysaccharidosis VI (Maroteaux-Lamy syndrome)
    Paul Harmatz
    Pediatric Clinical Research Center, Children s Hospital and Research Center at Oakland, California 94606, USA
    J Pediatr 144:574-80. 2004
    ..To evaluate the safety and efficacy of weekly treatment with human recombinant N-acetylgalactosamine 4-sulfatase (rhASB) in humans with mucopolysaccharidosis type VI (MPS VI)...
  31. pmc Sequencing and expression of two arsenic resistance operons with different functions in the highly arsenic-resistant strain Ochrobactrum tritici SCII24T
    Rita Branco
    IMAR Laboratory of Microbiology 3004 517 Coimbra, Portugal
    BMC Microbiol 8:95. 2008
    ..Organisms surviving in arsenic contaminated environments can have a diversity of mechanisms to resist to the harmful effects of arsenical compounds...
  32. pmc Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis VI (Maroteaux-Lamy syndrome)
    Trisha A Duffey
    Department of Chemistry, University of Washington, Seattle, Washington 98195, United States
    Anal Chem 82:9587-91. 2010
    ..4 μmol/(h L of blood), and an MPS-VI patient that had an activity of 0.12 μmol/(h L of blood). Results are also reported for the aryl sulfatase B assay in DBS from groups of normal felines and felines affected with MPS-VI...
  33. ncbi Speciation analysis of arsenic and selenium compounds in environmental and biological samples by ion chromatography-inductively coupled plasma dynamic reaction cell mass spectrometer
    Ruoh Yun Wang
    Department of Chemistry, National Sun Yat Sen University, Kaohsiung 80424, Taiwan
    Anal Chim Acta 590:239-44. 2007
    ..arsenite [As(III)], arsenate [As(V)], monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), arsenobetaine (AsB), selenite [Se(IV)] and selenate [Se(VI)]...
  34. ncbi [Construction and eukaryotic expression of recombinant plasmid encoding fusion protein of goat complement C3d and foot-and-mouth disease virus VP1]
    Jieyu Ling
    State Key Laboratory of Agricultural Microbiology, Wuhan 430070, China
    Sheng Wu Gong Cheng Xue Bao 24:209-13. 2008
    ..The goat C3d gene was cloned and three copies were tandem-linked with the linker (G4S)2 sequence...
  35. pmc Reversed papilledema in an MPS VI patient with galsulfase (Naglazyme) therapy
    Selim T Koseoglu
    Children s Hospital Oakland, 5275 Claremont Avenue, Oakland, CA 94618, USA
    Int Ophthalmol 29:267-9. 2009
    ..papilledema and improved visual acuity in an 11-year-old MPS VI patient receiving galsulfase (Naglazyme), an enzyme-replacement therapy (ERT) of recombinant human arylsulfatase B (rhASB) (Harmatz et al., J Pediatr 148(4), 533-539, 2006).
  36. pmc A superfamily of metalloenzymes unifies phosphopentomutase and cofactor-independent phosphoglycerate mutase with alkaline phosphatases and sulfatases
    M Y Galperin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    Protein Sci 7:1829-35. 1998
    ..Mutational changes in the vicinity of these residues in several sulfatases cause mucopolysaccharidosis (Hunter, Maroteaux-Lamy, Morquio, and Sanfilippo syndromes) and metachromatic leucodystrophy...
  37. ncbi Microsomal steroid sulfatase: interactions with cytosolic steroid sulfotransferases
    F C Kauffman
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Chem Biol Interact 109:169-82. 1998
    ..Unlike ARSA and ARSB, which are lysosomal, steroid sulfate sulfatase (ARSC, also known as STS) is localized exclusively in the ..
  38. pmc Genes involved in arsenic transformation and resistance associated with different levels of arsenic-contaminated soils
    Lin Cai
    State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, PR China
    BMC Microbiol 9:4. 2009
    ....
  39. ncbi Mutational analysis of mucopolysaccharidosis type VI patients undergoing a phase II trial of enzyme replacement therapy
    Litsa Karageorgos
    Lysosomal Diseases Research Unit, Department of Genetic Medicine, Children, Youth and Women s Health Service, North Adelaide, SA 5006, Australia
    Mol Genet Metab 90:164-70. 2007
    ..syndrome) is a lysosomal storage disorder caused by mutations in the N-acetylgalactosamine-4-sulfatase (ARSB) gene. These mutations result in a deficiency of ARSB activity...
  40. doi Enzyme replacement therapy for mucopolysaccharidosis VI from 8 weeks of age--a sibling control study
    J J McGill
    Department of Metabolic Medicine, Royal Children s Hospital, Hertson, QLD, Australia
    Clin Genet 77:492-8. 2010
    ..multisystem disorder caused by a deficiency of the lysosomal enzyme N-acetylgalactosamine-4-sulphatase (ASB)...
  41. ncbi A quantitative mannose 6-phosphate receptor-based in vitro assay for recombinant human N-acetylgalactosamine-4-sulfatase
    M Kleinig
    Research and Development Division, CSL Limited, 45 Poplar Road, Parkville, Victoria, 3052, Australia
    Anal Biochem 260:128-34. 1998
    ..Other possible applications of this assay are also discussed...
  42. pmc Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity
    Ji Yao Li
    Department of Surgery, University of Michigan, Ann Arbor 48109 0346, United States
    Cell Signal 19:1185-92. 2007
    b>Asb-4 is a gene that is specifically expressed in the hypothalamic energy homeostasis-associated areas and is down-regulated in the arcuate nucleus of fasted Sprague Dawley and obese Zucker rats...
  43. ncbi Meeting Report:The 7th ESPE Growth Plate Working Group Symposium - EUROGROP June 27th 2007, Helsinki, Finland
    Razvan L Miclea
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Pediatr Endocrinol Rev 5:680-5. 2007
    ..Abbreviations: 11beta-HSD: 11 Beta-Hydroxysteroid Dehydrogenase; Agc: Aggrecan; Aln: Alendronate; Asb- 4: Ankyrin Repeat and SOCS Box-Containing Protein 4; Atf6: Activating Transcription Factor6; BSP: Bisphosphonates; ..
  44. doi Ankyrin repeat and suppressor of cytokine signaling (SOCS) box-containing protein (ASB) 15 alters differentiation of mouse C2C12 myoblasts and phosphorylation of mitogen-activated protein kinase and Akt
    T G McDaneld
    Department of Animal Science, Iowa State University, Ames 50011, USA
    J Anim Sci 86:2897-902. 2008
    Ankyrin repeat and suppressor of cytokine signaling box-containing protein (ASB) 15 is a novel ASB gene family member predominantly expressed in skeletal muscle...
  45. pmc An Escherichia coli chromosomal ars operon homolog is functional in arsenic detoxification and is conserved in gram-negative bacteria
    C Diorio
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
    J Bacteriol 177:2050-6. 1995
    ..This chromosomal operon was cloned, sequenced, and found to consist of three cistrons which we named arsR, arsB, and arsC because of their strong homology to plasmid-borne ars operons...
  46. ncbi Targeted introduction of a diphtheria toxin resistant mutation into the chromosomal EF-2 locus of Pichia pastoris and expression of immunotoxin in the EF-2 mutants
    Yuan Yi Liu
    National Institute of Mental Health, NIH, Bethesda, MD 28092 4034, USA
    Protein Expr Purif 30:262-74. 2003
    ..When used to express the secreted bivalent anti-T cell immunotoxin, A-dmDT390-bisFv(G4S), the EF-2 mutant strains showed increased viability compared to the non-mutated strains...
  47. ncbi Complete remissions in chemotherapy of lung cancer models induced in mice by asbestos
    William E Smith
    Health Research Institute, Fairleigh Dickinson University, Madison, NJ, USA
    Mt Sinai J Med 72:23-32. 2005
    ..After treatments with a nitrosourea (PCNU), mice bearing transplants of a large-cell carcinoma (ASB XIV) had complete remissions (CR) in 13 of 20 animals on a 15 mg/kg regimen, in 6 of 20 on an 8 mg/kg regimen, and ..
  48. pmc Anchoring skeletal muscle development and disease: the role of ankyrin repeat domain containing proteins in muscle physiology
    Jin Ming Tee
    Hubrecht Institute for Developmental Biology and Stem Cell Research University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Crit Rev Biochem Mol Biol 45:318-30. 2010
    ..with Notch and developmental stage-specific expression of the members of the Ankyrin repeat and SOCS box (ASB) containing family of proteins controlling compartment size and guiding the various steps of muscle specification...
  49. doi Effect of probiotic-, bacteriophage-, or organic acid-supplemented feeds or fermented soybean meal on the growth performance, acute-phase response, and bacterial shedding of grower pigs challenged with Salmonella enterica serotype Typhimurium
    E Gebru
    Laboratory of Veterinary Pharmacokinetics and Pharmacodynamics, College of Veterinary Medicine, Kyungpook National University, Daegu, 702 701, Republic of Korea
    J Anim Sci 88:3880-6. 2010
    ..CT), a diet containing anti-Salmonella Typhimurium bacteriophage, 3 × 10(9) plaque-forming units/kg of feed (ASB), Lactobacillus plantarum CJLP56, 6.5 × 10(8) cfu/kg of feed (LP), 0...
  50. pmc Direct transfer of starter substrates from type I fatty acid synthase to type III polyketide synthases in phenolic lipid synthesis
    Akimasa Miyanaga
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Proc Natl Acad Sci U S A 105:871-6. 2008
    ..vinelandii are synthesized by two type III polyketide synthases (PKSs), ArsB and ArsC, which are encoded by the ars operon...
  51. doi Outcomes of minimally invasive endoscopic resection of anterior skull base neoplasms
    Pete S Batra
    Comprehensive Skull Base Program and Department of Otolaryngology Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Laryngoscope 120:9-16. 2010
    The objective of this study was to review clinical outcomes of minimally invasive endoscopic resection (MIER) for anterior skull base (ASB) neoplasms.
  52. ncbi Improved high-performance liquid chromatographic method for N-acetylgalactosamine-4-sulfate sulfatase (arylsulfatase B) activity determination using uridine diphospho-N-acetylgalactosamine-4-sulfate
    A J Leznicki
    Department of Biochemistry, Nicholas Copernicus University, Torun, Poland
    J Chromatogr B Biomed Sci Appl 696:193-202. 1997
    ..was isolated from hen oviduct (isthmus) with a yield of 31 mumol per 100 g of wet tissue and used for arylsulfatase B (ASB) activity determination...
  53. pmc Targeted disruption of the arylsulfatase B gene results in mice resembling the phenotype of mucopolysaccharidosis VI
    M Evers
    Abteilung Biochemie II, Universitat Gottingen, Germany
    Proc Natl Acad Sci U S A 93:8214-9. 1996
    ..VI) is a lysosomal storage disease with autosomal recessive inheritance caused by a deficiency of the enzyme arylsulfatase B (ASB), which is involved in degradation of dermatan sulfate and chondroitin 4-sulfate...
  54. ncbi Bicistronic lentiviral vector corrects beta-hexosaminidase deficiency in transduced and cross-corrected human Sandhoff fibroblasts
    Audrey Arfi
    Laboratoire de Genetique, Institut Cochin Université René Descartes Paris 5, INSERM U567, CNRS UMR 8104, 24 rue du Faubourg St Jacques, 75014 Paris, France
    Neurobiol Dis 20:583-93. 2005
    ..The bicistronic SIV.ASB vector enabled a massive restoration of beta-hexosaminidases activity on synthetic substrates and a 20% correction ..
  55. ncbi Toxicological responses in Laeonereis acuta (annelida, polychaeta) after arsenic exposure
    Juliane Ventura-Lima
    Departamento de Ciencias Fisiologicas, Fundação Universidade Federal do Rio Grande FURG, Rio Grande, RS, Brazil
    Environ Int 33:559-64. 2007
    ..a limited accumulation of related methylated As species and the levels of non-toxic As species like arsenobetaine (AsB) and arsenocholine (AsC) remained unchanged during the exposure period when compared with the controls...
  56. pmc Regulation and expression of the arsenic resistance operon from Staphylococcus aureus plasmid pI258
    G Ji
    Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago 60680
    J Bacteriol 174:3684-94. 1992
    ..The DNA sequence contains three genes in the order arsR, arsB, and arsC...
  57. pmc Cytokines in urine in elderly subjects with acute cystitis and asymptomatic bacteriuria
    Nils Rodhe
    Centre for Clinical Research, Dalarna, Sweden
    Scand J Prim Health Care 27:74-9. 2009
    Searching for useful diagnostic tools to discriminate between asymptomatic bacteriuria (ASB) and acute cystitis, this study compared urinary levels of cytokines/chemokines and leukocyte esterase in three groups of elderly subjects; those ..
  58. pmc Anti-IL5 decreases the number of eosinophils but not the severity of dermatitis in Sharpin-deficient mice
    Matthew L Renninger
    Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA
    Exp Dermatol 19:252-8. 2010
    ..Skin homogenates from mice treated with anti-IL5 had decreased mRNA expression of arylsulfatase B (Arsb), diamine oxidase (amiloride-binding protein 1, also called histaminase; Abp1) and Il10, which are ..
  59. doi Electronic memorandum decreases unnecessary antimicrobial use for asymptomatic bacteriuria and culture-negative pyuria
    Leslie A Linares
    Veterans Affairs Boston Health Care System, Boston, Massachusetts 02132, USA
    Infect Control Hosp Epidemiol 32:644-8. 2011
    Asymptomatic bacteriuria/candidiuria (ASB) and culture-negative pyuria (CNP) are common and often result in inappropriate antibiotic use...
  60. ncbi Enhanced resolution of glycosylphosphatidylinositol-anchored and transmembrane proteins from the lipid-rich myelin membrane by two-dimensional gel electrophoresis
    Christopher M Taylor
    Department of Neuroscience, MC 3401, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3401, USA
    Proteomics 3:1303-12. 2003
    ..We have identified two detergents, the nonionic n-dodecyl beta-D-maltoside and the zwitterionic amidosulfobetaine ASB-14, that are more effective in solubilizing myelin proteins than the commonly used zwitterionic detergent 3-[(3-..
  61. ncbi Molecular cloning and characterization of the human ASB-8 gene encoding a novel member of ankyrin repeat and SOCS box containing protein family
    Yongzhong Liu
    State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032, PR China
    Biochem Biophys Res Commun 300:972-9. 2003
    We have cloned a new member of human ankyrin repeat and SOCS box containing protein family (ASB), designed as hASB-8, from a human placental cDNA library and further extended by 5(') and 3(')-RACE...
  62. ncbi Combining the clinical signs improves diagnosis of scaphoid fractures. A prospective study with follow-up
    J Parvizi
    Department of Orthopaedics, Newcastle General Hospital, UK
    J Hand Surg Br 23:324-7. 1998
    ..scaphoid fracture were examined on two separate occasions to evaluate tenderness in the anatomical snuff box (ASB), tenderness over the scaphoid tubercle (ST), pain on longitudinal compression of the thumb (LC) and the range of ..
  63. ncbi Effect of alkaline-stabilized biosolids on alfalfa molybdenum and copper content
    Richard C Stehouwer
    Department of Crop and Soil Sciences, The Pennsylvania State University, University Park, PA 16802 3504, USA
    J Environ Qual 33:133-40. 2004
    ..Alkaline-stabilized biosolids (ASB) must be given particular consideration in assessment of Mo risk because the high pH of these biosolids could ..
  64. ncbi The influence of posterior capsular opacification removal on anterior segment birefringence parameters as measured by scanning laser polarimetry
    Jose J Garcia-Medina
    Ophthalmology Research Unit Santiago Grisolia, Department of Ophthalmology, Doctor Peset University Hospital, Valencia, Spain
    Clin Exp Ophthalmol 35:414-20. 2007
    To determine the effect of posterior capsular opacification (PCO) removal on anterior segment birefringence (ASB) and its influence on peripapillary retinal nerve fibre layer (RNFL) retardation measurements obtained by means of scanning ..
  65. ncbi Expression of murine Asb-9 during mouse spermatogenesis
    Man Ryul Lee
    Department of Anatomy and Cell Biology, Hanyang University, College of Medicine, Seoul 133 791, Korea
    Mol Cells 26:621-4. 2008
    We previously showed that Asb-4 and Asb-17 is uniquely expressed in developing male germ cells...
  66. pmc Expression of ankyrin repeat and suppressor of cytokine signaling box protein 4 (Asb-4) in proopiomelanocortin neurons of the arcuate nucleus of mice produces a hyperphagic, lean phenotype
    Ji Yao Li
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Endocrinology 151:134-42. 2010
    Ankyrin repeat and suppressor of cytokine signaling box-containing protein 4 (Asb-4) is specifically expressed in the energy homeostasis-related brain areas and colocalizes with proopiomelanocortin (POMC) neurons of the arcuate nucleus (..
  67. doi Endoscopic reconstruction of frontal, cribiform and ethmoid skull base defects
    David Chin
    University of New South Wales, Macquarie University, St Vincent s Hospital, Sydney, Australia
    Adv Otorhinolaryngol 74:104-18. 2013
    ..skull base reconstruction (ESBR) is an established option for complete reconstruction of the anterior skull base (ASB)...
  68. doi Phosphorylation of serine 323 of ASB2α is pivotal for the targeting of filamin A to degradation
    Rim Zakaria
    CNRS IPBS Institut de Pharmacologie et de Biologie Structurale, 205 route de Narbonne BP 64182, F 31077 Toulouse, France Université de Toulouse, UPS, IPBS, F 31077 Toulouse, France
    Cell Signal 25:2823-30. 2013
    b>ASB proteins are the specificity subunits of cullin5-RING E3 ubiquitin ligases (CRL5) that play roles in ubiquitin-mediated protein degradation. However, how their activity is regulated remains poorly understood...
  69. pmc Epidemiology and clinical outcomes of patients with carbapenem-resistant Klebsiella pneumoniae bacteriuria
    Zubair A Qureshi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 58:3100-4. 2014
    ..Patients with positive urine cultures for CRKP were classified as having asymptomatic bacteriuria (ASB) or symptomatic urinary tract infection (UTI)...
  70. pmc G-quadruplexes in viruses: function and potential therapeutic applications
    Mathieu Metifiot
    CNRS UMR 5234, Universite de Bordeaux, 146 rue Leo Saignat, 33076 Bordeaux, France
    Nucleic Acids Res 42:12352-66. 2014
    G-rich nucleic acids can form non-canonical G-quadruplex structures (G4s) in which four guanines fold in a planar arrangement through Hoogsteen hydrogen bonds...
  71. doi Multiple Forms and Settings of Exposure to Violence and Values: Unique and Interactive Relationships With Antisocial Behavior in Adolescence
    Dario Bacchini
    Second University of Naples, Caserta, Italy
    J Interpers Violence 30:3065-88. 2015
    ..multiple forms and settings of exposure to violence (ETV) as well as personal values and antisocial behavior (ASB) in adolescence...
  72. doi Conformational transition of a hairpin structure to G-quadruplex within the WNT1 gene promoter
    Margaret Hsin Jui Kuo
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 106, Taiwan, R O C
    J Am Chem Soc 137:210-8. 2015
    The role of G-quadruplexes (G4s) in biological systems has been widely studied. It is found that they have an important function in gene transcription and regulation...
  73. doi Differential antigenic protein recovery from Taenia solium cyst tissues using several detergents
    José Navarrete-Perea
    Department of Immunology, Institute for Biomedical Research, Universidad Nacional Autonoma de Mexico, Mexico D F 04510, Mexico
    Mol Biochem Parasitol 202:22-8. 2015
    ..Here, we describe the use of CHAPS, ASB-14 and Triton X-100, alone or in combination in the extraction buffers, as a strategy to notably increase the ..
  74. pmc Novel mutations of the arylsulphatase B (ARSB) gene in Indian patients with mucopolysaccharidosis type VI
    Anusha Uttarilli
    Diagnostics Division, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    Indian J Med Res 142:414-25. 2015
    ..enzymatic activity of N-acetyl galactosamine-4-sulphatase resulting from mutations in the arylsulphatase B (ARSB) gene. The ARSB gene is located on chromosome 5q11-q13 and is composed of eight exons...
  75. ncbi Identification of the membrane component of the anion pump encoded by the arsenical resistance operon of R-factor R773
    M J San Francisco
    Department of Biochemistry, Wayne State University School of Medicine, Detroit, Michigan 48201
    Mol Microbiol 3:15-21. 1989
    ..There are three structural genes, of which the product of the middle gene, arsB, has not previously been identified...
  76. ncbi Different susceptibility to lung tumorigenesis in mice with an identical Kras2 intron 2
    G Manenti
    Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy
    Genomics 29:438-44. 1995
    ..analysis to map pulmonary adenoma susceptibility (Pas) loci in an urethane-treated (A/J x Mus spretus) x C57BL/6J (ASB) interspecific testcross...
  77. ncbi Gender and outpatient mental health service use
    Anne E Rhodes
    Department of Psychiatry, University of Toronto, Canada
    Soc Sci Med 54:1-10. 2002
    ..as: a Mood and/or Anxiety Disorder (Mood/Anx) or a Substance Use Disorder and/or Antisocial Behaviours (Subs/Asb) within the past year. Use was defined in relation to providers seen within the past year...
  78. ncbi Isolation and characterization of arsenate-reducing bacteria from arsenic-contaminated sites in New Zealand
    Craig R Anderson
    Department of Microbiology, Otago School of Medical Sciences, University of Otago, P O Box 56, Dunedin, New Zealand
    Curr Microbiol 48:341-7. 2004
    ..Strain WK6 was positive for arsB, but the pathway of arsenate reduction for isolate CA1 was via a hitherto unknown mechanism...
  79. pmc Global analysis of cellular factors and responses involved in Pseudomonas aeruginosa resistance to arsenite
    Kislay Parvatiyar
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, OH 45267 0524, USA
    J Bacteriol 187:4853-64. 2005
    ..Mutants lacking the As(III) translocator (ArsB), superoxide dismutase (SOD), catabolite repression control protein (Crc), or glutathione reductase (Gor) were more ..
  80. ncbi Francisella tularensis proteome: low levels of ASB-14 facilitate the visualization of membrane proteins in total protein extracts
    Susan M Twine
    Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada
    J Proteome Res 4:1848-54. 2005
    ..5% amidosulfobetaine-14 (ASB-14) and 4% 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS)...
  81. ncbi Identification of differentially expressed genes in senescence-accelerated mouse testes by suppression subtractive hybridization analysis
    Takuya Chiba
    Department of Investigative Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852 8523, Japan
    Mamm Genome 18:105-12. 2007
    ..b>Asb-8, a member of ankyrin repeat-containing proteins, was abundantly expressed in the testes and downregulated in ..
  82. doi Strategies to recover proteins from ocular tissues for proteomics
    Nikhil Patel
    Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA
    Proteomics 8:1055-70. 2008
    ..3 to 50.7 mug protein/mg for different ocular tissues, with the lens yielding the most protein. ASB-14 and Triton X-100 provided the best protein yields (n = 10) for anterior and posterior sclera...
  83. pmc Construction of arsB and tetH mutants of the sulfur-oxidizing bacterium Acidithiobacillus caldus by marker exchange
    Leonardo J van Zyl
    Department of Microbiology, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa
    Appl Environ Microbiol 74:5686-94. 2008
    ..caldus were isolated. The functionality of the gene inactivation system was shown by the construction of A. caldus arsB and tetH mutants, and the effects of these mutations on cell growth in the presence of arsenic and by means of ..
  84. doi Simultaneous determination of epothilone D and its hydrolytic metabolite in human plasma by high performance liquid chromatography-tandem mass spectrometry for pharmacokinetic studies
    Chunling Zhang
    Laboratory of Drug Metabolism and Pharmacokinetics, Beijing Institute of Transfusion Medicine, 27 Taiping Road, Beijing 100850, China
    J Chromatogr B Analyt Technol Biomed Life Sci 877:3748-52. 2009
    ..Plasma samples were precipitated with acetonitrile, the analysis used a Venusil ASB C(18) analytical column...
  85. doi Complementary chromatography separation combined with hydride generation-inductively coupled plasma mass spectrometry for arsenic speciation in human urine
    Lydia W L Chen
    Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive, Edmonton, Alberta, Canada
    Anal Chim Acta 675:71-5. 2010
    ..However, the ion pair mode was unable to differentiate inorganic arsenite (As(III)) from arsenobetaine (AsB); instead, cation exchange chromatography was used to isolate and quantify AsB...
  86. ncbi [New possibilities in emergency medical transportation and emergency services of Polish Medical Air Rescue]
    Robert Gałazkowski
    Lotnicze Pogotowie Ratunkowe, Zakład Medycyny Ratunkowej, Warszawski Uniwersytet Medyczny
    Anestezjol Intens Ter 42:174-8. 2010
    ..Transport ventilators can work in a variety of ventilation modes including CMV, SIMV, SVV, BILEVEL, PCV, ASB, PPV and CPAP...
  87. doi Determination of arsenobetaine in fish tissue by species specific isotope dilution LC-LTQ-Orbitrap-MS and standard addition LC-ICPMS
    Lu Yang
    Institute for National Measurement Standard, National Research Council Canada, Ottawa, Ontario, Canada
    Anal Chem 83:3371-8. 2011
    An accurate and precise method for the determination of arsenobetaine (AsB, (CH(3))(3)(+)AsCH(2)COO(-)) in fish samples using exact matching species specific isotope dilution (ID) liquid chromatography LTQ-Orbitrap mass spectrometry (LC-..
  88. doi Transcriptional analysis of antibiotic resistance and virulence genes in multiresistant hospital-acquired MRSA
    Mireille Pruneau
    Departement de Biologie, Centre d étude et de valorisation de la diversité microbienne, Faculte des Sciences, Universite de Sherbrooke, QC, Canada
    FEMS Immunol Med Microbiol 63:54-64. 2011
    ..Genes encoding efflux pumps (norA, arsB, emrB) and the macrolide resistance gene ermA were found to be commonly expressed by HA-MRSA strains, but not in ..
  89. ncbi [Effectiveness comparison of anatomical single-bundle and over-the-top single-bundle reconstruction of anterior cruciate ligament]
    Yu Dong
    Sports Medicine Center, Department of Sports Medicine and Arthroscopy Surgery of Huashan Hospital, Fudan University, Shanghai 200040, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 25:912-5. 2011
    To compare the effectiveness of anatomical single-bundle (ASB) and over-the-top single-bundle (OSB) reconstruction of the anterior cruciate ligament (ACL).
  90. pmc Neonatal gene therapy with a gamma retroviral vector in mucopolysaccharidosis VI cats
    Katherine P Ponder
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Ther 20:898-907. 2012
    ..MPS) VI is due to a deficiency in the activity of N-acetylgalactosamine 4-sulfatase (4S), also known as arylsulfatase B. Previously, retroviral vector (RV)-mediated neonatal gene therapy reduced the clinical manifestations of MPS ..
  91. doi Celebrating the golden anniversary of anterior skull base surgery: reflections on the past 50 years and its historical evolution
    Qasim Husain
    Department of Otolaryngology Head and Neck Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Laryngoscope 123:64-72. 2013
    ..inception nearly half a century ago through the pioneering work of Dandy, McLean, and Smith, anterior skull base (ASB) surgery is a relatively young discipline...
  92. pmc Arylsulfatase B improves locomotor function after mouse spinal cord injury
    Myungsik Yoo
    W M Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, United States of America
    PLoS ONE 8:e57415. 2013
    ..We hypothesized that the mammalian enzyme arylsulfatase B (ARSB) would also enhance recovery after mouse spinal cord injury...
  93. pmc Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants
    Li Yang
    Peking University Sixth Hospital Institute of Mental Health, Beijing, China
    Am J Med Genet B Neuropsychiatr Genet 162:419-30. 2013
    ..Some common causal variants are likely to be shared between Han Chinese and Caucasians. Complex neurodevelopmental networks may underlie ADHD's etiology...
  94. ncbi Liquid chromatography-tandem mass spectrometry simultaneous determination of repaglinide and metformin in human plasma and its application to bioequivalence study
    Xiao Rong Liang
    Zhejiang University of Technology, Hangzhou 310014, China
    Yao Xue Xue Bao 48:547-53. 2013
    ..precipitation using acetonitrile as the precipitation solvent, both analytes and ISs were separated on a Venusil ASB C 18 (150 mm x 4...
  95. doi Rapid impact of phenanthrene and arsenic on bacterial community structure and activities in sand batches
    A Cébron
    LIEC UMR7360, CNRS Université de Lorraine, Faculté des Sciences et Technologies, BP 70239, 54506, Vandoeuvre les Nancy Cedex, France
    Microb Ecol 67:129-44. 2014
    ..transcripts revealed that arsenic induced the transcription of functional arsenic resistance and speciation genes (arsB, ACR3 and aioA), while no transcription of PAH-degradation genes (PAH-dioxygenase and catechol-dioxygenase) was ..
  96. pmc Attenuated osteoarticular phenotype of type VI mucopolysaccharidosis: a report of four patients and a review of the literature
    Agnieszka Jurecka
    Department of Medical Genetics, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730, Warsaw, Poland
    Clin Rheumatol 33:725-31. 2014
    ..OMIM 253200) is caused by mutations in the gene coding for N-acetylgalactosamine-4-sulfatase (4-sulfatase, arylsulfatase B, ARSB, EC 3.1.6.12), a lysosomal enzyme involved in the degradation of dermatan sulfate (DS)...
  97. pmc Sensory-motor behavioral characterization of an animal model of Maroteaux-Lamy syndrome (or Mucopolysaccharidosis VI)
    Paola Saccone
    1 Telethon Institute of Genetics and Medicine TIGEM, Naples, Italy 2 Institute of Genetics and Biophysics, CNR, Naples, Italy 3
    Sci Rep 4:3644. 2014
    Maroteaux-Lamy disease, also known as mucopolysaccharidosis (MPS) VI, is an MPS disorder caused by mutations in the ARSB gene encoding for the lysosomal enzyme arysulfatase B (ARSB)...
  98. pmc Metagenomic approach reveals variation of microbes with arsenic and antimony metabolism genes from highly contaminated soil
    Jinming Luo
    Key Laboratory of Drinking Water Science and Technology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, People s Republic of China University of Chinese Academy of Sciences, Beijing, People s Republic of China
    PLoS ONE 9:e108185. 2014
    ..The distribution, diversity and abundance of functional genes (including arsC, arrA, aioA, arsB and ACR3) were much higher for the samples containing higher As and Sb concentrations...
  99. pmc Childhood EEG frontal alpha power as a predictor of adolescent antisocial behavior: a twin heritability study
    Sharon Niv
    Department of Psychology, University of Southern California, United States Electronic address
    Biol Psychol 105:72-6. 2015
    ..to represent a state of low arousal in the brain, which has been related in past research to antisocial behavior (ASB)...
  100. doi Comparison of Type 1 D-3-phosphoglycerate dehydrogenases reveals unique regulation in pathogenic Mycobacteria
    Xiao Lan Xu
    Department of Developmental Biology, Washington University School of Medicine, 660 S Euclid Avenue, Box 8103, St Louis, MO 63110, United States
    Arch Biochem Biophys 570:32-9. 2015
    ..the properties of Type 1 PGDHs from seven different species and demonstrates that conserved residues in the ACT and ASB domains of some allow l-serine to act as a feedback inhibitor at low micromolar concentrations...
  101. doi Reversed Phase Column HPLC-ICP-MS Conditions for Arsenic Speciation Analysis of Rice Flour
    Tomohiro Narukawa
    National Metrology Institute of Japan NMIJ, National Institute of Advanced Industrial Science and Technology AIST
    Anal Sci 31:521-7. 2015
    ..acid (MMAA), dimethylarsinic acid (DMAA), trimethylarsine oxide (TMAO), tetramethylarsonium (TeMA), arsenobetaine (AsB) and arsenocholine (AsC), were separated and determined under the proposed conditions...

Research Grants53

  1. Asymptomatic Bacteriuria & Risk of Urinary Tract Infection in Renal Transplants
    JAMES CARTER RICE; Fiscal Year: 2010
    Asymptomatic bacteriuria (ASB) is the isolation of a specified quantity of bacteria from a person without symptoms or signs referableto urinary infection. ASB is common in women and increases with advancing age...
  2. Post-translational regulation of MLL in leukemogenesis
    ANDREW GEORGE MUNTEAN; Fiscal Year: 2012
    ..An expression analysis of the ASB family during hematopoietic development will be performed to test whether ASB proteins degrade MLL protein in ..
  3. ANDREW GEORGE MUNTEAN; Fiscal Year: 2014
    ..An expression analysis of the ASB family during hematopoietic development will be performed to test whether ASB proteins degrade MLL protein in ..
  4. Rembert Pieper; Fiscal Year: 2016
    ..colonization of long term-inserted urethral catheters results in CA-UTI versus asymptomatic bacteriuria (CA-ASB) are essentially not known, and causative factors pertaining to the host environment and complexity of microbial ..
  5. Development, Implementation and Evaluation of Novel Strategies to Reduce Inapprop
    CURTIS DONSKEY; Fiscal Year: 2010
    ..care settings because they are common and because treatment is often prescribed for asymptomatic bacteriuria (ASB), for which therapy is not indicated...
  6. Development of Externalizing Behavior Problems: Gene-Environment Interplay
    Laura A Baker; Fiscal Year: 2013
    ..study is a continuation into adulthood of a major longitudinal twin study of aggression and antisocial behavior (ASB) and its social and biological risk factors (#MH58354) in a diverse urban sample...
  7. Cranberry for Prevention of Bacteriuria in Pregnancy
    Deborah Wing; Fiscal Year: 2005
    ..Colonization of the urinary bladder, known as asymptomatic bacteriuria (ASB), often precedes the development of symptomatic urinary tract infections...
  8. FACTORS PREDISPOSING TO URINARY TRACT INFECTIOUS
    Walter Stamm; Fiscal Year: 1993
    ..spermicide alone with 300 new oral contraceptive users to determine the relative risk of asymptomatic bacteriuria (ASB) and symptomatic UTI in the first two groups...
  9. Notch-induced protein degradation in lymphopoiesis
    Xiao Hong Sun; Fiscal Year: 2013
    ..that Notch signaling stimulates the transcription of a family of ankyrin repeats and SOCS box containing proteins (Asb), which can promote the degradation of proteins targeted by Notch...
  10. Obesity is a Surgical Problem
    Michael W Mulholland; Fiscal Year: 2013
    ..analysis of hypothalamic gene expression changes has identified ankyrin repeat and SOCS box containing protein 4 (Asb-4) as a very promising investigative target...
  11. Hongkai Ji; Fiscal Year: 2014
    ..Third, a method for detecting allele-specific protein-DNA binding (ASB) will be developed...
  12. OLIGOSACCHARIDE STRUCTURE &FUNCTION IN RECOGNITION
    Jacques U Baenziger; Fiscal Year: 2012
    ..We have demonstrated by biochemical and genetic means that the Mannose/GalNAc-4-SO4-receptor (M/G4S-R) and the asialoglycoprotein-receptor (ASGP-R) mediate the respective clearance of glycoproteins that bear the N-..
  13. Deconvoluting G-quadruplex and i-Motif dynamics: the role of the physiological st
    Randy M Wadkins; Fiscal Year: 2013
    ..aims: 1) Quantify the kinetic and thermodynamic properties, nucleotide interactions, and underlying equilibrating G4s/iM structures in the presence of 5-hydroxymethylated cytosines and 2) Determine structural equilibria and protein-..
  14. Sugar-sweetened beverages and cardiovascular disease risk: an RCT
    David S Ludwig; Fiscal Year: 2013
    ..rising public health awareness of these potential adverse effects, consumption of artificially sweetened beverages (ASB) has increased dramatically...
  15. 1st International Thumb Osteoarthritis Workshop (ITOW)
    Joseph J Crisco; Fiscal Year: 2013
    ..aspects of CMC OA may be covered at other specialty meetings (such as the American Society of Biomechanics [ASB], the Orthopaedic Research Society [ORS], the Osteoarthritis Research Society International [OARSI], and the ..
  16. BIOCHEMICAL BASIS OF SULFATASE ACTIVITY
    ALLEN HORWITZ; Fiscal Year: 1992
    ..Antibody and cDNA probes for steroid sulfatase, iduronate sulfatase (Id-S) and arylsulfatase B (ASB) will be used to study the various levels of control of study the molecular basis of the genetic ..
  17. AIDS-related Animal Services Building Cage Washing Facility
    M Smith; Fiscal Year: 2007
    ..requests funds to renovate the old cage washing facility in the original part of the Animal Services Building (ASB) complex that houses nonhuman primates (NHPs)...
  18. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Andrew Morris; Fiscal Year: 2004
    ..This will be the seventh ASB conference on this subject...
  19. ASB1 Containment Expansion
    DANIEL MICHAEL DORSA; Fiscal Year: 2011
    ..This project proposes to construct an addition to the Animal Services Building (ASB) bio-containment space that will add six animal rooms and a kitchen...
  20. TRANSPORT ATPASE--ENERGY COUPLING
    Parjit Kaur; Fiscal Year: 1999
    ..It consists of an integral membrane protein ArsB that functions as a carrier, and a peripheral membrane protein ArsA that forms the catalytic subunit...
  21. OLIGOSACCHARIDE STRUCTURE AND FUNCTION IN RECOGNITION
    JACQUES BAENZIGER; Fiscal Year: 2007
    ..We previously defined how the Mannose/GalNAc-4-SO4-receptor (M/G4S-R) mediates the clearance of glycoproteins that bear the N-linked oligosaccharide signature of terminal GalNAc-4-..
  22. STRUCTURE/FUNCTION OF AN ION MOTIVE ATPASE
    DOMENICO GATTI; Fiscal Year: 2001
    ..The arsA and the arsB genes o the operon encode, respectively, the catalytic subunit (ATPase) and the membrane subunit of the pump...
  23. Barry P Rosen; Fiscal Year: 2016
    ..The ars operon codes for two regulatory (ArsR and ArsD) and three structural (ArsA, ArsB and ArsC) proteins. Resistance correlates with active extrusion of arsenite from the cell by a primary pump...
  24. Nonhuman Primate Primary Housing Units for Animal Services Building 3
    M Smith; Fiscal Year: 2006
    ..ASB3 is the third addition to the original ASB and will add an additional 900 housing spaces for NHPs in cages and small group housing units...
  25. ANTISOCIAL BEHAVIORS IN US AND ISLAND PUERTO RICAN YOUTH
    Hector Bird; Fiscal Year: 2004
    ..compares the development, the comorbidities and the risk factors of disruptive disorders and antisocial behaviors (ASB) in Puerto Rican children and adolescents in Puerto Rico (P.R.) and the mainland U.S...
  26. Meta-Analysis of Risk for Antisocial Behavior
    MARK LIPSEY; Fiscal Year: 2003
    APPLICANT?S DESCRIPTION: This research concerns antisocial behavior (ASB), i.e., intentional behavior that harms or threatens other persons or their property...
  27. 2004 Annual Meeting: American Society of Biomechanics
    Michael Bottlang; Fiscal Year: 2004
    Partial support is requested for the 28th annual meeting of the American Society of Biomechanics (ASB), hosted in Portland, Oregon from September 9th- 1lth, 2004...
  28. EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION
    PETER KOHLER; Fiscal Year: 2002
    This application requests funds to construct Phase II infill to the Animal Services Building (ASB) addition that will provide housing for 544 non-human primates (NHPs) in an 11,970 sq. ft. state-of-the art facility...
  29. Support for ASB Conference 2009 at Penn State University
    John Challis; Fiscal Year: 2009
    ..The annual conference this year will be held at the Pennsylvania State University on August 26-29, 2009. This application requests funds to reduce the registration fees of female and/or minority students. ..
  30. SUBSTRATE RECOGNITION IN MULTIDRUG RESISTANCE
    Barry Rosen; Fiscal Year: 1993
    ..Two of the structural genes, the arsA and arsB genes, encode the two subunits of the pump...
  31. Using CBPR to Design & Pilot a Physical Activity Program for Youth with ASB
    Richard Fleming; Fiscal Year: 2009
    ..Community-Based Participatory Research (CBPR) is ideally suited to such an endeavor, particularly in the ways it can facilitate involvement of families of children with ASD. ..
  32. Clinical Investigation of E.coli Biofilm Formation in the Human Bladder
    BARBARA TRAUTNER; Fiscal Year: 2007
    ..No effective strategy exists to prevent CAUTI in persons who require ongoing catheter use. Identifying genes that are required to cause CAUTI will lead to new strategies to prevent this illness. [unreadable] [unreadable] [unreadable]..
  33. Treatment and/or Prevention of Urinary Tract Infections
    BARBARA TRAUTNER; Fiscal Year: 2008
    ..An agent to prevent and treat UTI that does not encourage microbial resistance would have a significant impact on public health. [unreadable] [unreadable] [unreadable]..
  34. E. coli for prevention of Catheter UTI in SCI Patients
    BARBARA TRAUTNER; Fiscal Year: 2006
    ..The candidate plans to combine her clinical background in infectious diseases with the mentored research preformed under this award in order to reduce the secondary infectious complications of mobility disorders. ..
  35. TETHERED DOMAINS AS REGULATORY ELEMENTS
    Gregory Grant; Fiscal Year: 2009
    ..Our observations that PGDH from M. tuberculosis is inhibited by L-serine and that PGDH from humans is not, may provide a new focus in drug development for treatment of tuberculosis. ..
  36. HPA Axis Function in Adolescent Antisocial Females
    Kathleen Pajer; Fiscal Year: 2007
    ..abstract_text> ..
  37. PATHOGENESIS OF DISEASE IN MUCOPOLYSACCHARIDOSIS I AND VII
    Katherine P Ponder; Fiscal Year: 2010
    ..These studies may demonstrate that the development of disease in the aorta and the cervical spine in MPS is due to a common mechanism, and may identify a therapy for these difficult-to-treat sites. ..
  38. TLR5 and Pulmonary Innate Immunity
    THOMAS HAWN; Fiscal Year: 2009
    ..The immunogenetic models derived from these studies will illuminate the molecular basis of why individuals have different susceptibility to flagellated bacterial infections and hopefully culminate in novel insights for future therapies. ..
  39. Lysosomal Disease Network-4th Annual WORLD Symposium
    Chester Whitley; Fiscal Year: 2008
    ..The WORLD Symposium brings together researchers, physicians and patient advocates to advance medical science and public policy for such desperate problems. [unreadable] [unreadable] [unreadable]..
  40. Clinical Features in Nursing Home Residents with Suspected UTI
    Manisha Juthani Mehta; Fiscal Year: 2008
    ..This study will create an evidence-based definition of UTI. Future studies will identify residents with UTI in whom antibiotic therapy improves clinical outcome. [unreadable] [unreadable] [unreadable]..
  41. Lysosomal Disease Network-3rd Annual WORLD Symposium
    Chester Whitley; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  42. Regulation of BER Gene Expression by Folate Deficiency
    DIANE CABELOF; Fiscal Year: 2006
    ..The loss of the BER response to DNA damage when folate is deficient would establish a mechanism by which diet can alter susceptibility to environmental exposure. [unreadable] [unreadable] [unreadable]..
  43. IMPROVED METHODS FOR IN VIVO HEPATIC GENE THERAPY
    KATHERINE PONDER; Fiscal Year: 2006
    ..Success in this project might lead to a safe, effective, and permanent therapy for genetic deficiencies that involve proteins synthesized by the liver. ..
  44. Transdisciplinary Imaging Genetics Center (1 of 2)(RMI)
    Steven Potkin; Fiscal Year: 2006
    ..The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness. [unreadable] [unreadable]..
  45. Lysosomal Disease Network-2nd Annual WORLD Symposium
    Chester Whitley; Fiscal Year: 2005
    ..Sessions for patients and patient advocates will include educational presentations, support services, and round table discussions ..
  46. GENE THERAPY FOR BLOOD PROTEIN DEFICIENCIES
    KATHERINE PONDER; Fiscal Year: 2005
    ..Success in this project might lead to a safe, effective, and permanent therapy for Hemophilia B. ..
  47. Structure of Microsomal Enzymes in Estrogen Biosynthesis
    Debashis Ghosh; Fiscal Year: 2005
    ....
  48. Bacterial Cell Surfaces Gordon Conference
    Barry Rosen; Fiscal Year: 2004
    ..abstract_text> ..
  49. MOLECULAR GENETICS OF CHILDHOOD DISRUPTIVE DISORDERS
    Irwin Waldman; Fiscal Year: 2004
    ..The proposed study will increase substantially our understanding of specific genetic influences on the childhood disruptive disorders. ..
  50. Functional Organization of the Myelin Membrane
    Christopher Taylor; Fiscal Year: 2003
    ..in forming rafts in myelin, 3) provide a more complete understanding of the organization of proteins and lipids in myelin as well as identify potential targets for the therapeutic intervention in many myelin related disorders/diseases ..
  51. Toll-like Receptors and the Innate Immune Response
    THOMAS HAWN; Fiscal Year: 2003
    ..tuberculosis and L. major will reveal novel insights about innate immunity and infectious diseases that will have implications for vaccine development. ..