ARSA

Summary

Gene Symbol: ARSA
Description: arylsulfatase A
Alias: MLD, arylsulfatase A, ASA, cerebroside-sulfatase
Species: human

Top Publications

  1. ncbi Cloning and expression of human arylsulfatase A
    C Stein
    Biochemie II, Universitat Gottingen, Federal Republic of Germany
    J Biol Chem 264:1252-9. 1989
  2. ncbi A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency
    B Schmidt
    Universitat Gottingen, Federal Republic of Germany
    Cell 82:271-8. 1995
  3. pmc Multiple mutations are responsible for the high frequency of metachromatic leukodystrophy in a small geographic area
    U Heinisch
    Institut für Biochemie II, Universitat Gottingen, Germany
    Am J Hum Genet 56:51-7. 1995
  4. ncbi Metachromatic leukodystrophy in the Navajo Indian population: a splice site mutation in intron 4 of the arylsulfatase A gene
    N M Pastor-Soler
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Hum Mutat 4:199-207. 1994
  5. ncbi Contribution of arylsulfatase A mutations located on the same allele to enzyme activity reduction and metachromatic leukodystrophy severity
    Stefano Regis
    Laboratorio di Diagnosi Pre e Postnatale di Malattie Metaboliche, Istituto G Gaslini, Largo G Gaslini 5, 16147 Genova, Italy
    Hum Genet 110:351-5. 2002
  6. pmc Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2
    Ester Zito
    Telethon Institute of Genetics and Medicine TIGEM, Via P Castellino, 111, Naples, Italy
    EMBO Rep 6:655-60. 2005
  7. pmc Saposin B-dependent reconstitution of arylsulfatase A activity in vitro and in cell culture models of metachromatic leukodystrophy
    Ulrich Matzner
    Institut für Physiologische Chemie and LIMES, Membrane Biology and Lipid Biochemistry Unit, c o Kekulé Institut für Organische Chemie und Biochemie, Rheinische Friedrich Wilhelms University, 53115 Bonn, Germany
    J Biol Chem 284:9372-81. 2009
  8. ncbi Sphingolipidoses in Turkey
    Hatice Asuman Ozkara
    Department of Biochemistry, Hacettepe University Faculty of Medicine, 06100 Ankara, Turkey
    Brain Dev 26:363-6. 2004
  9. ncbi The frequency of lysosomal storage diseases in The Netherlands
    B J Poorthuis
    Dept of Pediatrics and Clinical Genetics, Leiden University of Medical Center, The Netherlands
    Hum Genet 105:151-6. 1999
  10. ncbi A non-glycosylated and functionally deficient mutant (N215H) of the sphingolipid activator protein B (SAP-B) in a novel case of metachromatic leukodystrophy (MLD)
    D Wrobe
    Kekule Institut fur Organische Chemie und Biochemie, Universitat Bonn, Germany
    J Inherit Metab Dis 23:63-76. 2000

Research Grants

  1. METACHROMATIC LEUKODYSTROPHY IN CULTURED CELL SYSTEMS
    Arvan Fluharty; Fiscal Year: 1990
  2. Ronald G Crystal; Fiscal Year: 2014
  3. A HTS assay to identify molecular probes for arylsulfatase A
    Gustavo Henrique Boff Maegawa; Fiscal Year: 2011
  4. Metachromatic Leukodystrophy Enzyme Drug Development
    KA WAI HUI; Fiscal Year: 2012
  5. KA WAI HUI; Fiscal Year: 2014
  6. Development of a Small Molecule Therapy for Metachromatic Leukodystrophy
    Brett E Crawford; Fiscal Year: 2012
  7. LEUKODYSTROPHIC STATES IN PSYCHIATRIC PATIENTS
    FRANK SCHOENFELD; Fiscal Year: 1992
  8. GENETICS OF HUMAN DEVELOPMENT AND METABOLIC DISEASE
    THOMAS SHOWS; Fiscal Year: 1992
  9. ASYMPTOMATIC METACHROMATIC LEUKODYSTROPHY SCREENING
    M Ullman; Fiscal Year: 1999
  10. Interaction of thrombospondin-1 with alpha9beta1 integrin in glioma angiogenesis
    Cezary Marcinkiewicz; Fiscal Year: 2012

Detail Information

Publications280 found, 100 shown here

  1. ncbi Cloning and expression of human arylsulfatase A
    C Stein
    Biochemie II, Universitat Gottingen, Federal Republic of Germany
    J Biol Chem 264:1252-9. 1989
    A full length cDNA for human arylsulfatase A was cloned and sequenced. The predicted amino acid sequence comprises 507 residues...
  2. ncbi A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency
    B Schmidt
    Universitat Gottingen, Federal Republic of Germany
    Cell 82:271-8. 1995
    ..It is proposed that the co- or posttranslational conversion of a cysteine to 2-amino-3-oxopropionic acid is required for generating catalytically active sulfatases and that deficiency of this protein modification is the cause of MSD...
  3. pmc Multiple mutations are responsible for the high frequency of metachromatic leukodystrophy in a small geographic area
    U Heinisch
    Institut für Biochemie II, Universitat Gottingen, Germany
    Am J Hum Genet 56:51-7. 1995
    Metachromatic leukodystrophy is a lysosomal storage disorder caused by the deficiency of arylsulfatase A. The disease occurs panethnically, with an estimated frequency of 1/40,000...
  4. ncbi Metachromatic leukodystrophy in the Navajo Indian population: a splice site mutation in intron 4 of the arylsulfatase A gene
    N M Pastor-Soler
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Hum Mutat 4:199-207. 1994
    ..This metabolic block is often due to defective functioning of the lysosomal enzyme arylsulfatase A (ARSA)...
  5. ncbi Contribution of arylsulfatase A mutations located on the same allele to enzyme activity reduction and metachromatic leukodystrophy severity
    Stefano Regis
    Laboratorio di Diagnosi Pre e Postnatale di Malattie Metaboliche, Istituto G Gaslini, Largo G Gaslini 5, 16147 Genova, Italy
    Hum Genet 110:351-5. 2002
    The occurrence of different mutations on the same arylsulfatase A allele is not uncommon, due to the high frequency of several variants, among which the pseudodeficiency mutations are particularly important...
  6. pmc Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2
    Ester Zito
    Telethon Institute of Genetics and Medicine TIGEM, Via P Castellino, 111, Naples, Italy
    EMBO Rep 6:655-60. 2005
    ..Here, we show that SUMF2 inhibits the enhancing effects of SUMF1 on sulphatases, suggesting that the SUMF1-SUMF2 interaction represents a further level of control of these sulphatase activities...
  7. pmc Saposin B-dependent reconstitution of arylsulfatase A activity in vitro and in cell culture models of metachromatic leukodystrophy
    Ulrich Matzner
    Institut für Physiologische Chemie and LIMES, Membrane Biology and Lipid Biochemistry Unit, c o Kekulé Institut für Organische Chemie und Biochemie, Rheinische Friedrich Wilhelms University, 53115 Bonn, Germany
    J Biol Chem 284:9372-81. 2009
    b>Arylsulfatase A (ASA) catalyzes the intralysosomal desulfation of 3-O-sulfogalactosylceramide (sulfatide) to galactosylceramide...
  8. ncbi Sphingolipidoses in Turkey
    Hatice Asuman Ozkara
    Department of Biochemistry, Hacettepe University Faculty of Medicine, 06100 Ankara, Turkey
    Brain Dev 26:363-6. 2004
    ..A total of 300 patients (15%) with sphingolipidoses were diagnosed; there were deficiencies of arylsulfatase A [metachromatic leukodystrophy (MLD)] in 93 (31%), hexosaminidase [Sandhoff disease (SHD)] in 62 (20...
  9. ncbi The frequency of lysosomal storage diseases in The Netherlands
    B J Poorthuis
    Dept of Pediatrics and Clinical Genetics, Leiden University of Medical Center, The Netherlands
    Hum Genet 105:151-6. 1999
    ..Within the group of lipidoses, metachromatic leukodystrophy (MLD) is the most frequent LSD. MLD was diagnosed in 24% of lipidoses and the calculated birth prevalence was 1...
  10. ncbi A non-glycosylated and functionally deficient mutant (N215H) of the sphingolipid activator protein B (SAP-B) in a novel case of metachromatic leukodystrophy (MLD)
    D Wrobe
    Kekule Institut fur Organische Chemie und Biochemie, Universitat Bonn, Germany
    J Inherit Metab Dis 23:63-76. 2000
    ..accumulation of sulphatides and other sphingolipids, resulting in variant forms of metachromatic leukodystrophy (MLD)...
  11. ncbi Pitfalls in the diagnosis of multiple sulfatase deficiency
    G M Mancini
    Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Neuropediatrics 32:38-40. 2001
    ..Here we report a 3-year old Iranian girl with an MLD-like presentation of MSD. Arylsulfatase A deficiency and sulfatide excretion were found...
  12. ncbi AAV1 mediated co-expression of formylglycine-generating enzyme and arylsulfatase a efficiently corrects sulfatide storage in a mouse model of metachromatic leukodystrophy
    Toshiyuki Kurai
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Mol Ther 15:38-43. 2007
    Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused by a deficiency of arylsulfatase A (ASA) and is characterized by deposition of sulfatide in all organs, particularly the nervous system...
  13. doi In vitro correction of ARSA deficiency in human skin fibroblasts from metachromatic leukodystrophy patients after treatment with microencapsulated recombinant cells
    Valeska Lizzi Lagranha
    Postgraduate Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Metab Brain Dis 23:469-84. 2008
    Metachromatic leukodystrophy (MLD) is an autosomal recessive disorder due to arylsulfatase A (ARSA) deficiency that affects primarily the central nervous system...
  14. ncbi Sedation for children with metachromatic leukodystrophy undergoing MRI
    Cristina Mattioli
    Neurosurgical Anesthesia and Intensive Care Unit, Institute Hospital S Raffaele, Milan, Italy
    Paediatr Anaesth 17:64-9. 2007
    Metachromatic leukodystrophy (MLD) is a lysosomal storage disease with infantile and juvenile onset with a poor prognosis and magnetic resonance imaging (MRI) plays a fundamental role in its diagnosis...
  15. ncbi Enzyme, cell and gene-based therapies for metachromatic leukodystrophy
    C Sevin
    University Rene Descartes Paris 5, INSERM U745, Paris, France
    J Inherit Metab Dis 30:175-83. 2007
    ..leukodystrophy (MLD) is a demyelinating storage disease caused by deficiency of the lysosomal enzyme arylsulfatase A (ARSA)...
  16. ncbi Specific downregulation and mistargeting of the lipid raft-associated protein MAL in a glycolipid storage disorder
    K Saravanan
    Institute of Physiological Chemistry, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Neurobiol Dis 16:396-406. 2004
    Metachromatic leukodystrophy (MLD) is a lysosomal lipid storage disease caused by arylsulfatase A deficiency. In MLD patients the sphingolipid sulfatide increasingly accumulates leading to progressive demyelination...
  17. ncbi Atypical clinical course in juvenile metachromatic leukodystrophy involving novel arylsulfatase A gene mutations
    Banu Anlar
    Hacettepe University Faculty of Medicine, Department of Paediatric Neurology, Ankara, Turkey
    Dev Med Child Neurol 48:383-7. 2006
    ..juvenile metachromatic leukodystrophy (MLD) with unusual manifestations are presented, each involving a novel arylsulfatase A gene mutation...
  18. ncbi [Metachromatic leukodystrophy (MLD) and Multiple sulphatase deficiency (MSD)]
    Y Eto
    Department of Pediatrics, Tokyo Jikei University
    Nihon Rinsho 53:2994-3003. 1995
    MLD is caused by a deficiency of arylsulfatase A and hence sulfolipids are accumulated in various patient's tissues. Various clinical phenotypes including activator deficiency, pseudodeficiency and MSD...
  19. ncbi Metabolic correction in oligodendrocytes derived from metachromatic leukodystrophy mouse model by using encapsulated recombinant myoblasts
    Antonella Consiglio
    Telethon Institute for Gene Therapy TIGET and DIBIT, San Raffaele Scientific, Institute, Milan, Italy
    J Neurol Sci 255:7-16. 2007
    In an effort to develop an encapsulated cell-based system to deliver arylsulfatase A (ARSA) to the central nervous system of metachromatic leukodystrophy (MLD) patients, we engineered C2C12 mouse myoblasts with a retroviral vector ..
  20. doi Identification of a novel splicing mutation in the ARSA gene in a patient with late-infantile form of metachromatic leukodystrophy
    Dong Hee Kang
    Department of Laboratory Medicine and Genetics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea
    Korean J Lab Med 30:516-20. 2010
    ..a severe neurodegenerative disorder inherited as an autosomal recessive trait, is caused by mutations in the arylsulfatase A (ARSA) gene...
  21. ncbi Motor and psycho-cognitive clinical types in adult metachromatic leukodystrophy: genotype/phenotype relationships?
    Nicole Baumann
    Laboratory of Neurochemistry, INSERM Unit 495, Salpetriere Hospital, Paris, France
    J Physiol Paris 96:301-6. 2002
    ..The deficient enzyme is a lysosomal hydrolase, cerebroside sulfate sulfatase (arylsulfatase A). MLD is both a dysmyelinating and a demyelinating disease...
  22. ncbi Sulfogalactosylceramides in motor and psycho-cognitive adult metachromatic leukodystrophy: relations between clinical, biochemical analysis and molecular aspects
    Benoit Colsch
    University Pierre and Marie Curie UMR CNRS 7613, 4 place Jussieu, 75252 Paris Cedex 05, France
    Biochim Biophys Acta 1780:434-40. 2008
    ..It is due to the enzyme deficiency of the sulfatide sulfatase i.e. arylsulfatase A (ASA). During adolescence and/or adulthood, there are 2 clinical presentations...
  23. doi Multipotential neural precursors transplanted into the metachromatic leukodystrophy brain fail to generate oligodendrocytes but contribute to limit brain dysfunction
    M I Givogri
    Department of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Dev Neurosci 30:340-57. 2008
    ..Transplanted MLD mice showed an improved arylsulfatase A (ARSA) activity and a significant amelioration of sulfatide metabolism, neurodegeneration and motor-learning/..
  24. doi Metachromatic leukodystrophy - mutation analysis provides further evidence of genotype-phenotype correlation
    A Biffi
    San Raffaele Telethon Institute for Gene Therapy Paediatric Clinical Research Unit, San Raffaele Scientiffic Institute, Milan, Italy
    Clin Genet 74:349-57. 2008
    ..leukodystrophy (MLD) is a rare lysosomal storage disorder resulting from the inherited deficiency of the arylsulfatase A (ARSA) enzyme. Currently, no valid therapeutic options are available for affected patients...
  25. doi Efficient intracerebral delivery of AAV5 vector encoding human ARSA in non-human primate
    Marie Anne Colle
    UMR INRA 703, Ecole Veterinaire de Nantes, Nantes, France
    Hum Mol Genet 19:147-58. 2010
    ..leukodystrophy (MLD) is a lethal neurodegenerative disease caused by a deficiency in the lysosomal arylsulfatase A (ARSA) enzyme leading to the accumulation of sulfatides in glial and neuronal cells...
  26. ncbi Delay of myelin formation in arylsulphatase A-deficient mice
    Afshin Yaghootfam
    Institut fur Physiologische Chemie, Rheinische Friedrich Wilhelms Universitat Bonn, Nussallee 11, 53115 Bonn, Germany
    Eur J Neurosci 21:711-20. 2005
    Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused by the deficiency of arylsulphatase A (ASA)...
  27. pmc Gene therapy of metachromatic leukodystrophy reverses neurological damage and deficits in mice
    Alessandra Biffi
    San Raffaele Telethon Institute for Gene Therapy, Vita Salute San Raffaele University, Milan, Italy
    J Clin Invest 116:3070-82. 2006
    ..The efficacy of gene therapy was dependent on and proportional to arylsulfatase A (ARSA) overexpression in the microglia progeny of transplanted HSPCs...
  28. ncbi Partial cure of established disease in an animal model of metachromatic leukodystrophy after intracerebral adeno-associated virus-mediated gene transfer
    C Sevin
    Institut National de la Santé et de la Recherche Médicale Inserm U745, Laboratory of Molecular Genetics and Université ParisV, Paris, France
    Gene Ther 14:405-14. 2007
    Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by genetic deficiency of arylsulfatase A (ARSA) enzyme...
  29. doi Site-specific analysis of N-linked oligosaccharides of recombinant lysosomal arylsulfatase A produced in different cell lines
    Stephan Schröder
    Rheinische Friedrich Wilhelms Universitat, Institut fur Biochemie und Molekularbiologie, Nussallee 11, D 53115 Bonn, Germany
    Glycobiology 20:248-59. 2010
    ..leukodystrophy (MLD) is a lysosomal storage disease caused by a deficiency of the lysosomal enzyme arylsulfatase A (ASA). Enzyme replacement therapy (ERT) is a therapeutic option for MLD and other lysosomal disorders...
  30. doi Molecular bases of metachromatic leukodystrophy in Polish patients
    Agnieszka Lugowska
    Department of Genetics, Institute of Psychiatry and Neurology, Al Sobieskiego 9, Warsaw, Poland
    J Hum Genet 55:394-6. 2010
    ..patients suffering from different types of metachromatic leukodystrophy (MLD) showed that four mutations in the ARSA gene accounted for 55% of mutated alleles (c.459+1G>A, p.P426L, p.I179S and c.1204+1G>A)...
  31. ncbi Retrovirally expressed human arylsulfatase A corrects the metabolic defect of arylsulfatase A-deficient mouse cells
    U Matzner
    Institut fur Physiologische Chemie, Rheinische Friedrich Wilhelms Universitat, Nussallee 11, 53115 Bonn, Germany
    Gene Ther 7:805-12. 2000
    A deficiency of arylsulfatase A (ASA) causes the lysosomal storage disease metachromatic leukodystrophy (MLD) which is characterized primarily by demyelination of the central nervous system...
  32. ncbi Characterization of a recombinant molecule covalently indistinguishable from human cerebroside-sulfate activator protein (CSAct or Saposin B)
    J P Whitelegge
    The Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences, The Neuropsychiatric Institute, University of California, 405 Hilgard Ave, Los Angeles, CA 90095, USA
    Cell Mol Biol (Noisy-le-grand) 49:799-807. 2003
    ..CSAct activity can be measured in vitro by assay of its ability to activate sulfatide-sulfate hydrolysis by arylsulfatase A or ex vivo by its ability to functionally complement CSAct deficient fibroblast cell lines derived from MLD ..
  33. pmc Microglia: a cellular vehicle for CNS gene therapy
    Harald Neumann
    Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University of Bonn, and LIFE and BRAIN Center and Hertie Foundation, Bonn, Germany
    J Clin Invest 116:2857-60. 2006
    Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by deficiency of the enzyme arylsulfatase A (ARSA). MLD is characterized by progressive demyelination and neurological deficits...
  34. ncbi Novel candidate disease for gene therapy: metachromatic leukodystrophy
    Alessandra Biffi
    San Raffaele Telethon Institute for Gene Therapy and Vita Salute University, H San Raffaele Scientific Institute, Milan, Italy a biffi hsr it
    Expert Opin Biol Ther 7:1193-205. 2007
    Metachromatic leukodystrophy (MLD) is a rare, fatal, inherited, autosomal recessive, lysosomal storage disorder, characterized by severe and progressive demyelination affecting the central and peripheral nervous systems...
  35. ncbi Polymorphisms in genes encoding the serotonin and dopamine pathways in two sisters with metachromatic leukodystrophy
    H G Kumperscak
    Department of Paediatrics, Child and Adolescent Psychiatry Unit, University Clinical Centre Maribor, Maribor, Slovenia
    J Int Med Res 36:1123-8. 2008
    Metachromatic leukodystrophy (MLD) is a metabolic disease that has recently been investigated as a model for the study of psychosis...
  36. doi Identification of a new Arylsulfatase A (ARSA) gene mutation in Tunisian patients with metachromatic leukodystrophy (MLD)
    Imen Dorboz
    Child Neurological Diseases Unit, Faculty of Medicine, Tunis, Tunisia
    J Neurol Sci 287:278-80. 2009
    ..MLD) is an autosomal recessive, lysosomal storage disease caused by a deficiency of the enzyme arylsulfatase A (ARSA). The aim of the present study was to identify the molecular basis of MLD in Tunisian population...
  37. pmc Successful treatment of metachromatic leukodystrophy using bone marrow transplantation of HoxB4 overexpressing cells
    Noriko Miyake
    Department of Biochemistry and Molecular Biology, Division of Gene Therapy Research, Center for Advanced Medical Technology, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Mol Ther 18:1373-8. 2010
    ..effectiveness of BM cells expressing the homeobox B4 (HoxB4) gene to cure mice with metachromatic leukodystrophy (MLD) through transplantation...
  38. doi Metachromatic leukodystrophy--an update
    V Gieselmann
    Department of Physiology, University of Bonn, Germany
    Neuropediatrics 41:1-6. 2010
    ..Metachromatic leukodystrophy (MLD) is a rare lysosomal sphingolipid storage disorder, caused by a deficiency of arylsulfatase A (ASA). It is inherited in an autosomal recessive way, among Caucasians three causing alleles are frequent...
  39. ncbi Malignant lymphoproliferative diseases in HIV-seropositive patients. A study of 40 cases at a single institution in Spain
    A Ribas
    Medical Oncology Section, Hospital General Vall d'Hebron, Barcelona, Spain
    Acta Oncol 34:75-82. 1995
    We identified 40 patients with malignant lymphoproliferative diseases (MLD) and HIV infection (seropositive) at a single Spanish university hospital...
  40. ncbi Treatment of breast-cancer-related lymphedema with or without manual lymphatic drainage--a randomized study
    L Andersen
    Department of Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 39:399-405. 2000
    A prospective randomized study was carried out to investigate whether the addition of manual lymphatic drainage (MLD) to the standard therapy could improve treatment outcome in women with lymphedema of the ipsilateral arm after breast ..
  41. ncbi Characterization of iodothyronine sulfatase activities in human and rat liver and placenta
    Monique H A Kester
    Department of Internal Medicine, Erasmus University Medical School, 3000 DR Rotterdam, The Netherlands
    Endocrinology 143:814-9. 2002
    ..the hydrolysis of iodothyronine sulfates by homogenates of V79 cells expressing the human arylsulfatases A (ARSA), B (ARSB), or C (ARSC; steroid sulfatase), as well as tissue fractions of human and rat liver and placenta...
  42. pmc Characterization of the minimum domain required for targeting budding yeast myosin II to the site of cell division
    Ida M B Lister
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    BMC Biol 4:19. 2006
    ..Unlike most other class II myosins, the tail of Myo1 has an irregular coiled coil. In this report we use molecular genetics, biochemistry and live cell imaging to characterize the minimum localisation domain (MLD) of budding yeast Myo1.
  43. ncbi Slowing of sensory conduction of the median nerve and carpal tunnel syndrome in Japanese and American industrial workers
    P A Nathan
    Portland Hand Surgery and Rehabilitation Center, Oregon
    J Hand Surg Br 19:30-4. 1994
    ..We used the maximum latency difference (MLD) with a critical value of > or = 0.40 msec to indicate abnormal slowing of nerve conduction...
  44. pmc Oxypurinol improves coronary and peripheral endothelial function in patients with coronary artery disease
    Stephan Baldus
    Department of Cardiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Free Radic Biol Med 39:1184-90. 2005
    ..incremental doses of intracoronary acetylcholine (ACh; 10(-7) to 10(-5) microM), and minimal lumen diameter (MLD) and coronary blood flow (CBF) were assessed before and after intravenous administration of oxypurinol (200 mg)...
  45. pmc Exploring the optimum approach to the use of CT densitometry in a randomised placebo-controlled study of augmentation therapy in alpha 1-antitrypsin deficiency
    David G Parr
    Department of Respiratory Medicine, University Hospitals of Coventry and Warwickshire, Clifford Bridge Road, Coventry CV22DX, UK
    Respir Res 10:75. 2009
    ....
  46. ncbi [Relationship of dose-volume histogram parameters and computed tomography grading of radiation-induced lung injury in patients with non-small cell lung cancer treated by three-dimensional conformal radiotherapy]
    Jun Xing
    Department of Radiation Oncology, Shandong Cancer Hospital, Jinan 250117, China
    Zhonghua Zhong Liu Za Zhi 30:676-81. 2008
    ....
  47. ncbi Effect of pravastatin on angiographic restenosis after coronary balloon angioplasty. The PREDICT Trial Investigators. Prevention of Restenosis by Elisor after Transluminal Coronary Angioplasty
    M E Bertrand
    Division of Cardiology B, Hopital Cardiologique, Lille, France
    J Am Coll Cardiol 30:863-9. 1997
    ..This study sought to determine whether pravastatin affects clinical or angiographic restenosis after coronary balloon angioplasty...
  48. pmc A pilot, prospective evaluation of a novel alternative for maintenance therapy of breast cancer-associated lymphedema [ISRCTN76522412]
    Olivia Wilburn
    Stanford Center for Lymphatic and Venous Disorders, Stanford University School of Medicine, Falk Cardiovascular Research Center, Stanford, California 94305, USA
    BMC Cancer 6:84. 2006
    ..investigations of complete decongestive lymphatic physiotherapy (CDPT), including manual lymphatic drainage (MLD), have validated the efficacy of these interventions for the initial reduction of edema and long-term maintenance ..
  49. ncbi Clinical and angiographic outcomes after use of 90Strontium/90Yttrium beta radiation for the treatment of in-stent restenosis: results from the Stents and Radiation Therapy 40 (START 40) registry
    Mohan Suntharalingam
    Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Int J Radiat Oncol Biol Phys 52:1075-82. 2002
    ..To evaluate the safety and efficacy of a 40-mm 90Strontium/90Yttrium source train in the management of in-stent restenosis within native coronary arteries...
  50. ncbi Significance of plasma transforming growth factor-beta levels in radiotherapy for non-small-cell lung cancer
    Katrien De Jaeger
    Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 58:1378-87. 2004
    ..The aim of this study was to evaluate prospectively the time course of TGF-beta1 levels in patients irradiated for NSCLC in relation to the development of RP and dose-volume parameters...
  51. ncbi [Coronary angioplasty in women: risk factors and sex-related differences in coronary anatomy evaluated with intravascular ultrasonography]
    Anna Sonia Petronio
    Dipartimento Cardio Toracico, Universita degli Studi, Pisa
    Ital Heart J Suppl 3:71-7. 2002
    ..The aim of this study was to evaluate the risk factors for cardiovascular diseases, clinical presentation and coronary anatomical size differences in women...
  52. ncbi 'Fused-Gold' vs. 'Bare' stainless steel NIRflex stents of the same geometric design in diseased native coronary arteries. Long-term results from the NIR TOP Study
    Stephen Fort
    Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
    EuroIntervention 3:256-61. 2007
    ..Primary endpoint was minimal luminal diameter (MLD) at 6 months angiographic follow-up...
  53. ncbi C terminal half fragment (50 kDa) of heavy chain components of Clostridium botulinum type C and D neurotoxins can be used as an effective vaccine
    Jae Chul Lee
    Department of Bacteriology, Okayama University Medical School, Okayama, Japan
    Microbiol Immunol 51:445-55. 2007
    ..After immunization, the mice were challenged with up to 10(6) the minimum lethal doses (MLD)/0.5 ml of C or D toxin, the type of which was same as that of the immunogens...
  54. doi In vitro antimicrobial effect and in vivo preventive and therapeutic effects of partially purified lantibiotic lacticin NK34 against infection by Staphylococcus species isolated from bovine mastitis
    S Y Kim
    Department of Microbiology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151 742, Korea
    J Dairy Sci 93:3610-5. 2010
    ..identify the 2 strains from each group with the greatest lacticin NK34 susceptibility, and the minimal lethal dose (MLD) was measured in ICR (imprinting control region) mice...
  55. ncbi [Balloon angioplasty for restenosis of coronary endoprostheses]
    N Debbas
    Division de cardiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Suisse
    Arch Mal Coeur Vaiss 88:987-91. 1995
    ..In particular, there were no dissections. The minimal lumenal diameter (MLD) and percentage stenosis changed from 1.04 mm (range: 0.87 to 1...
  56. ncbi Detection of botulinal neurotoxins A, B, E, and F by amplified enzyme-linked immunosorbent assay: collaborative study
    Joseph L Ferreira
    U S Food and Drug Administration, 60 8th St NE, Atlanta, GA 30309, USA
    J AOAC Int 86:314-31. 2003
    ..by the AOAC method, and the cultures were then diluted, if necessary, to high (about 10,000 minimal lethal dose [MLD]/mL) and low (about 100 MLD/mL) test samples...
  57. ncbi Fatal pneumonitis associated with intensity-modulated radiation therapy for mesothelioma
    Aaron M Allen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 65:640-5. 2006
    ..To describe the initial experience at Dana-Farber Cancer Institute/Brigham and Women's Hospital with intensity-modulated radiation therapy (IMRT) as adjuvant therapy after extrapleural pneumonectomy (EPP) and adjuvant chemotherapy...
  58. ncbi Clinical characteristics and outcome of immunoglobulin M-related disorders
    Clara Cesana
    Department of Hematology, Niguarda Ca Granda Hospital, Piazza Ospedale Maggiore 3, 20162 Milan, Italy
    Clin Lymphoma 5:261-4. 2005
    ..factors for transformation of immunoglobulin Mrelated disorders (IgM-RDs) to malignant lymphoproliferative disease (MLD) in 83 patients with IgM-RDs...
  59. pmc Direct transfer of starter substrates from type I fatty acid synthase to type III polyketide synthases in phenolic lipid synthesis
    Akimasa Miyanaga
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Proc Natl Acad Sci U S A 105:871-6. 2008
    ..Here, we show that two type I fatty acid synthases (FASs), ArsA and ArsD, which are members of the ars operon, are responsible for the biosynthesis of C(22)-C(26) fatty acids from ..
  60. doi Surface chemistry for molecular layer deposition of organic and hybrid organic-inorganic polymers
    Steven M George
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA
    Acc Chem Res 42:498-508. 2009
    ..Molecular layer deposition (MLD) methods extend this strategy to include organic and hybrid organic-inorganic polymeric materials...
  61. ncbi [Studies on the enteropathogenic mechanism of non-O1 Vibrio cholerae. II. Lethality, adhesion, colonization and cytopathogenicity of enteropathogenic strains]
    Y Gyobu
    Toyama Institute of Health
    Kansenshogaku Zasshi 65:665-71. 1991
    ..The following results were obtained. 1) Minimum lethal doses (MLD) of enteropathogenic strains were significantly lower than those of non-enteropathogenic strains...
  62. ncbi Comparison of chemonucleolysis and microsurgical discectomy for the treatment of herniated lumbar disc
    H E Zeiger
    Department of Surgery, University of Alabama, Birmingham
    Spine (Phila Pa 1976) 12:796-9. 1987
    ..herniated lumbar disc who were treated by either chemonucleolysis (CN) or microsurgical lumbar discectomy (MLD) was reviewed retrospectively. Of the 45 patients who chose chemonucleolysis, 27 (60%) reported a good outcome...
  63. ncbi Microlumbar discectomy (MLD)
    F Zahrawi
    Department of Orthopedic Surgery, Lake Hospital, West, Willoughby, Ohio
    Spine (Phila Pa 1976) 13:358-9. 1988
    This is a retrospective study of microlumbar discectomy (MLD), performed between 1983 and 1987. During that period, 60 patients underwent the procedure. At follow-up, after an average of 33...
  64. ncbi Caenorhabditis elegans expresses a functional ArsA
    Yuen Yi Tseng
    Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan
    FEBS J 274:2566-72. 2007
    ..Bacterial ArsA ATPase is the catalytic component of an oxyanion pump that is responsible for resistance to arsenite (As(III)) and ..
  65. doi A severe symptom phenotype in tomato in Mali is caused by a reassortant between a novel recombinant begomovirus (Tomato yellow leaf curl Mali virus) and a betasatellite
    Li Fang Chen
    Department of Plant Pathology, University of California, Davis, CA 95616, USA
    Mol Plant Pathol 10:415-30. 2009
    ..monopartite begomovirus with a hybrid genome composed of sequences from Tomato yellow leaf curl virus-Mild (TYLCV-Mld) and Hollyhock leaf crumple virus (HoLCrV)...
  66. ncbi Inactivation of bee venom phospholipase A2 by manoalide. A model based on the reactivity of manoalide with amino acids and peptide sequences
    K B Glaser
    Biochem Pharmacol 36:2079-86. 1987
    The marine natural product manoalide (MLD), a potent irreversible inhibitor of bee venom phospholipase A2 (PLA2), was shown to produce a chromophore (lambda max = 437 nm) during incubation with the enzyme...
  67. ncbi Metachromatic leukodystrophy: molecular genetics and an animal model
    V Gieselmann
    Biochemisches Institut der Christian Albrechts Universität zu Kiel, Germany
    J Inherit Metab Dis 21:564-74. 1998
    Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused by the deficiency of arylsulphatase A (ASA; EC 3.1.6.8). Deficiency of this enzyme causes intralysosomal storage of the sphingolipid cerebroside sulphate...
  68. ncbi Dental asymmetry in temporomandibular disorders
    K Fushima
    Department of Orthodontics, Kanagawa Dental College, Yokosuka, Japan
    J Oral Rehabil 26:752-6. 1999
    In our previous study, it was reported that facial asymmetry due to mandibular lateral displacement (MLD) was significant in patients with temporomandibular disorders (TMD)...
  69. ncbi Longitudinal straightening effect of stents is an additional predictor for major adverse cardiac events. Austrian Wiktor Stent Study Group and European Paragon Stent Investigators
    M Gyongyosi
    2nd Department of Internal Medicine, University Medical School of Vienna, Austria
    J Am Coll Cardiol 35:1580-9. 2000
    ....
  70. ncbi Hemorrhagic cholecystitis as a likely cause of nontraumatic hemobilia in metachromatic leukodystrophy: report of a case
    N Vettoretto
    Clinica Chirurgica, Universita di Brescia
    Ann Ital Chir 72:725-8. 2001
    A 17-years-old man with the juvenile form of MLD developed massive hemobilia. CT and US scans showed blood and clots filling the gallbladder and the biliary ways, with no bleeding source seen at selective angiography...
  71. ncbi The experience of manual lymph drainage as an aspect of treatment for lymphoedema
    Mary Woods
    Lymphoedema Services, The Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK
    Int J Palliat Nurs 9:336-42; discussion 342. 2003
    ..aim of this study was to develop an understanding of the patient's experience of a course of manual lymph drainage (MLD for cancer-related lymphoedema. The study used an interpretative approach...
  72. ncbi Incidence and predictors of late total occlusion following coronary stenting
    Pinak B Shah
    Cardiovascular Division, St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    Catheter Cardiovasc Interv 60:344-51. 2003
    ..001), smaller reference vessel diameter (P = 0.022), smaller preprocedure minimum lumen diameter (MLD; P = 0.004), and smaller postprocedure MLD (P = 0.036)...
  73. ncbi Bladed balloon angioplasty for peripheral pulmonary artery stenosis
    Hisashi Sugiyama
    Department of Pediatrics, Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Ontario, Canada
    Catheter Cardiovasc Interv 62:71-7. 2004
    ..The minimal lumen diameter (MLD) before and after the procedure, whether there was a waist at initial BA, and BB diameter-to-MLD ratio before the ..
  74. ncbi Influences of breathing patterns on respiratory sinus arrhythmia in humans during exercise
    Gregory Blain
    Department of Ergonomics, University of Toulon Var, La Gorde, France
    Am J Physiol Heart Circ Physiol 288:H887-95. 2005
    ..The instantaneous RSA frequency (FRSA, in Hz) and amplitude (ARSA, in ms) were then extracted from all recordings. A(RSA) was calculated with short-time Fourier transform...
  75. ncbi Clinical and angiographic predictors of luminal changes beyond 6 months after implantation of thicker strut coronary stents
    Kenji Sadamatsu
    Division of Cardiology, St Mary s Hospital, Kurume, Japan
    Circ J 69:35-8. 2005
    ..The purpose of this study was to clarify the clinical and angiographic predictors of late changes in minimal lumen diameter (MLD) after 6-month follow-up of stenting.
  76. ncbi The yeast Arr4p ATPase binds the chloride transporter Gef1p when copper is available in the cytosol
    Jutta Metz
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, Heidelberg D 69120, Germany
    J Biol Chem 281:410-7. 2006
    ..We have identified the yeast homologue of the prokaryotic ArsA protein, the homodimeric ATPase Arr4p, as a protein that binds to the yeast intracellular CLC chloride-transport ..
  77. ncbi Kinetics of the immune response to the (F1+V) vaccine in models of bubonic and pneumonic plague
    E D Williamson
    Dstl Porton Down, Salisbury, Wilts SP4 0JQ, UK
    Vaccine 25:1142-8. 2007
    Protection against aerosol challenge with > 300 MLD of Yersinia pestis was observed 7 days after a single immunisation of mice with the F1+V vaccine...
  78. ncbi Utility of endoscopic ultrasound in the diagnosis of aberrant right subclavian artery
    Tony E Yusuf
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Gastroenterol Hepatol 22:1717-21. 2007
    Aberrant right subclavian artery (ARSA) is the most common congenital anomaly of the aortic arch occurring in 0.4-2.0% of the general population...
  79. ncbi Characterization of the metalloactivation domain of an arsenite/antimonite resistance pump
    Xiang Ruan
    Department of Biochemistry and Molecular Biology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Mol Microbiol 67:392-402. 2008
    ..The ArsA ATPase, the catalytic subunit of the pump, has two homologous halves, A1 and A2...
  80. doi Is it a fact? Timed arithmetic performance of children with mathematical learning disabilities (MLD) varies as a function of how MLD is defined
    Michele M M Mazzocco
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Dev Neuropsychol 33:318-44. 2008
    Poor fact retrieval is a frequently reported characteristic of children with mathematical learning disability (MLD)...
  81. ncbi Localized tissue water changes accompanying one manual lymphatic drainage (MLD) therapy session assessed by changes in tissue dielectric constant inpatients with lower extremity lymphedema
    H N Mayrovitz
    College of Medical Sciences, Nova Southeastern University, Ft Lauderdale, Florida 33328, USA
    Lymphology 41:87-92. 2008
    ..For this purpose, we measured changes in TDC produced by one MLD treatment in 27 legs of 18 patients with lower extremity lymphedema. TDC values were measured to a depth of 2...
  82. ncbi Psychoacoustic tests for central auditory processing: normative data
    Rafi Shemesh
    Department of Communication Disorders, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel
    J Basic Clin Physiol Pharmacol 19:249-59. 2008
    ..The integrity of auditory brainstem processing was evaluated by quantifying masking level difference (MLD) values and gap detection (GD) thresholds...
  83. ncbi Late progression after sirolimus-eluting stent implantation for de novo lesions--comparison with bare metal stent implantation
    Nobuo Shiode
    Department of Cardiology, Matsue Red Cross Hospital, Matsue, Japan
    Circ J 74:1104-10. 2010
    In previous studies, the minimal luminal diameter (MLD) of lesions treated with a bare metal stent (BMS) was shown to improve from 6 months to 3 years...
  84. pmc Connections of the auditory brainstem in a songbird, Taeniopygia guttata. I. Projections of nucleus angularis and nucleus laminaris to the auditory torus
    Nils O E Krützfeldt
    Department of Anatomy, Faculty of Medical and Health Sciences, University of Auckland, PB 92019 Auckland, New Zealand
    J Comp Neurol 518:2109-34. 2010
    ..of NA and NL to the torus semicircularis, known in birds as nucleus mesencephalicus lateralis, pars dorsalis (MLd), and in mammals as the central nucleus of the inferior colliculus (ICc)...
  85. pmc Fact retrieval deficits in low achieving children and children with mathematical learning disability
    David C Geary
    University of Missouri, Columbia, MO 65211 2500, USA
    J Learn Disabil 45:291-307. 2012
    ..severe (LA-severe fact retrieval; n = 18) fact retrieval deficits and mathematically learning disabled children (MLD; n = 15) were identified...
  86. pmc The DBA.2 mouse is susceptible to disease following infection with a broad, but limited, range of influenza A and B viruses
    Natalie Pica
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    J Virol 85:12825-9. 2011
    ..2 and C57BL/6 mice generate comparable humoral responses upon equivalent 50% mouse lethal dose (MLD(50)) challenges with influenza virus. Our data demonstrate the utility of DBA...
  87. ncbi [Study on pancreas of type 1 diabetic mice induced by MLD-STZ using proteomics]
    Miao Geng
    Institute of Geriatrics, Division of South Building, Chinese PLA General Hospital, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 27:357-61. 2011
    To get a better understanding of the mechanisms underlying type 1 diabetes mellitus, the differentially expressed pancreatic proteins from multiple low-dose streptozotocin (MLD-SIZ) mouse and normal mouse were analyzed and compared.
  88. doi Effects of multi-metal toxicity on the performance of sewage treatment system during the festival of colors (Holi) in India
    Vinay Kumar Tyagi
    Department of Civil Engineering, Indian Institute of Technology Roorkee, Roorkee 247667, India
    Environ Monit Assess 184:7517-29. 2012
    ..The present study investigated the effects of heavy metals (Ni, Zn, Cd, Cu, and Pb) toxicity on the performance of 18 MLD activated sludge process-based sewage treatment plant (STP) during celebration of Holi (festival of colors in India)..
  89. pmc Cerebral gray and white matter changes and clinical course in metachromatic leukodystrophy
    Samuel Groeschel
    Department of Pediatric Neurology and Developmental Medicine, University Children s Hospital, Tubingen, Germany
    Neurology 79:1662-70. 2012
    Metachromatic leukodystrophy (MLD) is a rare metabolic disorder leading to demyelination and rapid neurologic deterioration. As therapeutic options evolve, it seems essential to understand and quantify progression of the natural disease...
  90. pmc Effects of manual lymphatic drainage on breast cancer-related lymphedema: a systematic review and meta-analysis of randomized controlled trials
    Tsai Wei Huang
    Division of General Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan
    World J Surg Oncol 11:15. 2013
    Lymphedema is a common complication of axillary dissection for breast cancer. We investigated whether manual lymphatic drainage (MLD) could prevent or manage limb edema in women after breast-cancer surgery.
  91. doi Advanced three-dimensional quantitative coronary angiographic assessment of bifurcation lesions: methodology and phantom validation
    Chrysafios Girasis
    Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    EuroIntervention 8:1451-60. 2013
    ..Validation of new three-dimensional (3-D) bifurcation quantitative coronary angiography (QCA) software...
  92. doi Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy
    Alessandra Biffi
    San Raffaele Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, 20132 Milan, Italy
    Science 341:1233158. 2013
    Metachromatic leukodystrophy (MLD) is an inherited lysosomal storage disease caused by arylsulfatase A (ARSA) deficiency. Patients with MLD exhibit progressive motor and cognitive impairment and die within a few years of symptom onset...
  93. pmc Vaccines within vaccines: the use of adenovirus types 4 and 7 as influenza vaccine vectors
    Eric A Weaver
    Division of Infectious Diseases Mayo Clinic Rochester, MN USA
    Hum Vaccin Immunother 10:544-56. 2014
    ..immunized with serial dilutions of viruses expressing the HA1-con influenza vaccine gene were challenged with 100 MLD 50 of influenza virus. Ad4 protected BALB/c mice at a lower dose by i.m. immunization as compared with Ad7...
  94. doi Chimney technique for aortic dissection involving an aberrant right subclavian artery
    Makoto Samura
    Department of Surgery, Yamaguchi Grand Medical Center, Hofu, Japan Electronic address
    Ann Thorac Surg 97:315-7. 2014
    ..a case involving a ruptured acute type B aortic dissection originating from an aberrant right subclavian artery (ARSA)...
  95. pmc A novel phosphatidylinositol 4,5-bisphosphate binding domain mediates plasma membrane localization of ExoU and other patatin-like phospholipases
    Gregory H Tyson
    From the Departments of Microbiology Immunology
    J Biol Chem 290:2919-37. 2015
    ..We confirmed that the membrane localization domain (MLD) of ExoU had a direct affinity for PI(4,5)P2, and we determined that this binding was required for ExoU ..
  96. doi Acute Liver Failure in Infants and Young Children in a Specialized Pediatric Liver Centre in India
    Seema Alam
    Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India
    Indian J Pediatr 82:879-83. 2015
    To study the etiological spectrum of acute liver failure in infants and young children and to identify clinical and biochemical markers for metabolic liver disease (MLD).
  97. doi Vascular Anomalies Associated with Esophageal Atresia and Tracheoesophageal Fistula
    Stéphanie Berthet
    Division of Pediatric Gastroenterology Hepatology and Nutrition, Sainte Justine University Health Centre, Montreal, Quebec, Canada
    J Pediatr 166:1140-1144.e2. 2015
    ..atresia (EA) and tracheoesophageal fistula (TEF) while describing the clinical presentation, diagnosis, and consequences, and to evaluate the diagnostic value of esophagram in diagnosing an aberrant right subclavian artery (ARSA).
  98. pmc Role of ASXL1 and TP53 mutations in the molecular classification and prognosis of acute myeloid leukemias with myelodysplasia-related changes
    Raynier Devillier
    Hematology Department, Institut Paoli Calmettes, Marseille, France
    Oncotarget 6:8388-96. 2015
    ..AML) with myelodysplasia-related changes (AML-MRC) are defined by the presence of multilineage dysplasia (MLD), and/or myelodysplastic syndrome (MDS)-related cytogenetics, and/or previous MDS...
  99. pmc Slowing down of North Pacific climate variability and its implications for abrupt ecosystem change
    Chris A Boulton
    Earth System Science, College of Life and Environmental Sciences, University of Exeter, Exeter EX4 4QE, United Kingdom
    Proc Natl Acad Sci U S A 112:11496-501. 2015
    ..When looking ahead, despite model limitations in simulating mixed layer depth (MLD) in the North Pacific, global warming is robustly expected to decrease MLD...
  100. doi Stable measures of number sense accuracy in math learning disability: Is it time to proceed from basic science to clinical application?
    Annelise Júlio-Costa
    Programa de Pós Graduação em Neurociências, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Psych J 4:218-25. 2015
    Math learning disability (MLD) or developmental dyscalculia is a highly prevalent and persistent difficulty in learning arithmetic that may be explained by different cognitive mechanisms...
  101. pmc Rapid accumulation and low degradation: key parameters of Tomato yellow leaf curl virus persistence in its insect vector Bemisia tabaci
    Nathalie Becker
    Institut de Systématique, Evolution, Biodiversité ISYEB UMR 7205 CNRS, MNHN, UPMC, EPHE Muséum national d Histoire naturelle, Sorbonne Universités, 57 rue Cuvier, CP 50, F 75005, Paris, France
    Sci Rep 5:17696. 2015
    ..We monitored two major TYLCV strains, Mild (Mld) and Israel (IL), in the invasive B...

Research Grants47

  1. METACHROMATIC LEUKODYSTROPHY IN CULTURED CELL SYSTEMS
    Arvan Fluharty; Fiscal Year: 1990
    ..The cerebroside sulfatase hydrolytic system must be viewed as a multi-component system...
  2. Ronald G Crystal; Fiscal Year: 2014
    ..leukodystrophy (MLD), an autosomal recessive lysosomal storage disorder caused by a deficiency in arylsulfatase A (ARSA)...
  3. A HTS assay to identify molecular probes for arylsulfatase A
    Gustavo Henrique Boff Maegawa; Fiscal Year: 2011
    ..I hypothesize that I can identify molecular probes that would restore arylsulfatase A (ASA), lysosomal enzyme deficient in metachromatic leukodystrophy (MLD), a neurodegenerative LSD for which a ..
  4. Metachromatic Leukodystrophy Enzyme Drug Development
    KA WAI HUI; Fiscal Year: 2012
    ..leukodystrophy (MLD) is an genetic disease caused by mutations in the gene encoding the lysosomal enzyme, arylsulfatase A (ASA)...
  5. KA WAI HUI; Fiscal Year: 2014
    ..by applicant): Metachromatic Leukodystrophy or MLD, is a genetic disease that affects the lysosomal enzyme, arylsulfatase A (ASA)...
  6. Development of a Small Molecule Therapy for Metachromatic Leukodystrophy
    Brett E Crawford; Fiscal Year: 2012
    ..MLD is a rare genetic condition found in 1 in 40,000 births that is caused by a deficiency in the lysosomal arylsulfatase A (ASA) or saposin B (SAPB) [1, 2]...
  7. LEUKODYSTROPHIC STATES IN PSYCHIATRIC PATIENTS
    FRANK SCHOENFELD; Fiscal Year: 1992
    ..The presence of metachromatic leukodystrophy (MLD) is indicated by a decrease in Aryl sufatase A (ASA) activity...
  8. GENETICS OF HUMAN DEVELOPMENT AND METABOLIC DISEASE
    THOMAS SHOWS; Fiscal Year: 1992
    ..To accomplish this, 2 sets of lysosomal enzyme disorders will be studied: the mucolipidoses and the arylsulfatase A deficiency disorders...
  9. ASYMPTOMATIC METACHROMATIC LEUKODYSTROPHY SCREENING
    M Ullman; Fiscal Year: 1999
    Asymptomatic infants who are destined to die from metachromatic leukodystrophy (MLD), can be identified by urine positive for sulfatides...
  10. Interaction of thrombospondin-1 with alpha9beta1 integrin in glioma angiogenesis
    Cezary Marcinkiewicz; Fiscal Year: 2012
    ..we intend to prove that the blocking of a9[unreadable]1 integrin by a specific monoclonal antibody or by a MLD-disintegrin, VLO5 will suppress the development of experimental glioma by blocking the vascularization process...
  11. Calculations, Word Problems, and Algebraic Cognition
    Lynn S Fuchs; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mathematics learning disabilities (MLD) affect 5-9% of the school-age population, leading to life-long difficulties that create financial burdens and a public health problem for society...
  12. Development of Therapeutic Pan-Filovirus Macaque Monoclonal Antibodies
    Sven G Enterlein; Fiscal Year: 2013
    ..Crystallographic studies show that the RBR is masked by the bulky mucin-like domain (MLD)...
  13. Developing Number Sense in Children at Risk for Mathematics Learning Disabilities
    Nancy C Jordan; Fiscal Year: 2013
    ..application is to develop and test a number sense intervention for children at risk for math learning disabilities (MLD)...
  14. MASSAGE THERAPY FOR EXPERIMENTAL LYMPHEDEMA
    Marlys Witte; Fiscal Year: 2002
    DESCRIPTION (Applicant's Abstract): Massage therapy (in the form of Manual Lymph Drainage (MLD) or Manual Lymphedema Treatment (MLT) is an integral component of the international consensus-recommended optimal treatment for lymphedema(LE)..
  15. Vinod Menon; Fiscal Year: 2016
    ..provided new insights into the enduring behavioral deficits in children with mathematical learning disabilities (MLD)...
  16. Vinod Menon; Fiscal Year: 2014
    ..Our proposed studies focus on three groups of children: (1) children with mathematical learning disabilities (MLD) who have persistent disabilities (low achievement across grades), (2) low achieving but variable (LA-V) children ..
  17. CHIROPTICAL SPECTROSCOPY OF METALLOPROTEINS
    Philip Stephens; Fiscal Year: 1990
    ..We also propose to develop new instrumentation and theory for the study of magnetic linear dichroism (MLD)...
  18. Inflammatory Cytokines Associated Symptom Burden in NSCLC Patients Receiving CXRT
    Xin Wang; Fiscal Year: 2009
    ..volumes of normal lung being irradiated (evidenced by radiation dose-volume histogram (DVH) and mean lung dose (MLD)) in patients treated with either IMRT or 3DCRT...
  19. TRANSPORT ATPASE--ENERGY COUPLING
    Parjit Kaur; Fiscal Year: 1999
    ..It consists of an integral membrane protein ArsB that functions as a carrier, and a peripheral membrane protein ArsA that forms the catalytic subunit...
  20. Nichole M Scaglione; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Numerous studies have identified alcohol-related sexual assault (ARSA) as a nation-wide problem, especially among college women who experience sexual assault at nearly four times the national rate...
  21. STRUCTURE/FUNCTION OF AN ION MOTIVE ATPASE
    DOMENICO GATTI; Fiscal Year: 2001
    ..The arsA and the arsB genes o the operon encode, respectively, the catalytic subunit (ATPase) and the membrane subunit of ..
  22. Barry P Rosen; Fiscal Year: 2016
    ..The ars operon codes for two regulatory (ArsR and ArsD) and three structural (ArsA, ArsB and ArsC) proteins. Resistance correlates with active extrusion of arsenite from the cell by a primary pump...
  23. MOLECULAR BIOLOGY OF CENTRAL NERVOUS SYSTEM MYELINATION
    Brian Popko; Fiscal Year: 1993
    ..gene encoding the myelin basic protein (MBP) will be analyzed in the dysmyelinating murine mutant myelin deficient (mld)...
  24. LYSOSOMAL ENZYMES
    JOHN O BRIEN; Fiscal Year: 1990
    ..A second goal is to complete the isolation of a cDNA coding for arylsulfatase A, perform DNA sequence analysis for this cDNA, map the precise chromosomal location of ARSA and determine ..
  25. SUBSTRATE RECOGNITION IN MULTIDRUG RESISTANCE
    Barry Rosen; Fiscal Year: 1993
    ..The genes have cloned and sequenced, and the protein components purified. Two of the structural genes, the arsA and arsB genes, encode the two subunits of the pump...
  26. BINAURAL INFORMATION PROCESSING
    Leslie Bernstein; Fiscal Year: 1993
    ..from masking which can be obtained when dichotic as compared to diotic signals are employed (the high-frequency MLD)...
  27. EFFECTS OF AGING ON BINAURAL AND SPATIAL HEARING
    Janet Koehnke; Fiscal Year: 2000
    ..g., MLD) and a spatial detection task...
  28. LEARNING DISABILITIES IN ELEMENTARY MATHEMATICS
    DAVID GEARY; Fiscal Year: 2003
    ....
  29. Mathematical Development in Learning Diasbled Children
    DAVID GEARY; Fiscal Year: 2003
    ..g., working memory) that underlie MD children's developmental delays and deficits in these competencies. ..
  30. Dose-Volume Modeling of Late Rectal and Bladder Toxicity
    Susan Tucker; Fiscal Year: 2007
    ..We expect the results of our analyses to play an important role in furthering the development of conformal techniques in RT of the prostate and other pelvic sites. ..
  31. Biochemical correlates/cognition/Barth syndrome
    MICHELE MAZZOCCO; Fiscal Year: 2004
    ..Methods will involve cognitive assessment of children with Barth syndrome and matched peers, paired comparisons, and correlation analyses. ..
  32. MULTIPLEX ANALYSIS OF INBORN ERRORS OF METABOLISM
    Michael Gelb; Fiscal Year: 2001
    ..abstract_text> ..
  33. Conference on Drug Against Tropical Protozoan Parasites
    Michael Gelb; Fiscal Year: 2002
    ..We consider the poster sessions that occur throughout our meeting to be just as important as the collection of lecture presentations. ..
  34. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Michael Gelb; Fiscal Year: 2002
    ....
  35. SCHOOL AGE CONSEQUENCES OF <750 GRAM BIRTHWEIGHT
    H Taylor; Fiscal Year: 2002
    ..Results will clarify the long-term sequelae of less than 750 g birth weight and shed light on the bases of both adverse consequences and developmental sparing. ..
  36. NEUROBIOLOGY OF COGNITIVE IMPAIRMENT IN CHILDREN WITH NF
    Bartlett Moore; Fiscal Year: 2003
    ..and medical specialists involved with these patients, "Given that a particular child has or doesn't have brain anomalies, and does or does not have learning difficulties, what will this child be like in the future"? ..
  37. Massage Therapy for Breast Cancer-related Lymphedema
    Michael Bernas; Fiscal Year: 2003
    Massage therapy [in the form of Manual Lymph Drainage (MLD)] is an integral component, with compression bandaging (CB), of Combined Physical Therapy (CPT), the international consensus-recommended optimal treatment for peripheral ..
  38. ATP-DEPENDENT PROTEIN KINASES IN GRAM-POSITIVE BACTERIA
    Milton Saier; Fiscal Year: 2004
    ..abstract_text> ..
  39. Early School Progress in <1000g Birthweight Children
    H Gerry Taylor; Fiscal Year: 2010
    ..The findings will inform efforts to identify and treat learning disorders in high-risk children at school entry. ..
  40. Bacterial Cell Surfaces Gordon Conference
    Barry Rosen; Fiscal Year: 2004
    ..abstract_text> ..
  41. Targeting alfa 1beta1 integrin in cancer development
    Cezary Marcinkiewicz; Fiscal Year: 2007
    ..abstract_text> ..
  42. Functional Language Organization in Childhood Stroke
    ANNA BYARS; Fiscal Year: 2006
    ..The findings will contribute to the understanding of brain plasticity, language development, and assessment and treatment of language disorders. ..
  43. COGNITIVE AND GENETIC CORRELATES OF EARLY MATH SKILLS
    MICHELE MAZZOCCO; Fiscal Year: 2006
    ..abstract_text> ..
  44. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2006
    ..These studies will contribute to our fundamental understanding of how mammalian cells initiate the eicosanoid cascade. ..
  45. Structure of Microsomal Enzymes in Estrogen Biosynthesis
    Debashis Ghosh; Fiscal Year: 2005
    ....