ARRB2

Summary

Gene Symbol: ARRB2
Description: arrestin beta 2
Alias: ARB2, ARR2, BARR2, beta-arrestin-2, arrestin 3
Species: human

Top Publications

  1. pmc Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor 1 (CB1)
    Kwang H Ahn
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269, USA
    J Biol Chem 288:9790-800. 2013
  2. doi Molecular mechanisms involved in activity of h7C10, a humanized monoclonal antibody, to IGF-1 receptor
    Matthieu Broussas
    Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, BP 60497, Saint Julien en Genevois, France
    Int J Cancer 124:2281-93. 2009
  3. pmc β-Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma
    Huiyuan Zheng
    Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet and Karolinska University Hospital, 17176 Stockholm, Sweden
    Proc Natl Acad Sci U S A 109:20620-5. 2012
  4. ncbi Gravin-mediated formation of signaling complexes in beta 2-adrenergic receptor desensitization and resensitization
    F Lin
    Department of Molecular Pharmacology, Diabetes and Metabolic Diseases Research Program, University Medical Center, State University of New York, Stony Brook, New York 11794 8651, USA
    J Biol Chem 275:19025-34. 2000
  5. ncbi Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein-coupled receptor trafficking
    You Me Kim
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    J Biol Chem 277:30760-8. 2002
  6. pmc Multiple scaffolding functions of {beta}-arrestins in the degradation of G protein-coupled receptor kinase 2
    Laura Nogués
    Departamento de Biologia Molecular and Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Biol Chem 286:1165-73. 2011
  7. ncbi Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling
    Yaya Wang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    Nat Immunol 7:139-47. 2006
  8. ncbi Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype
    Rasmus Jorgensen
    7TM Pharma A S, Horsholm, DK 2970, Denmark
    Mol Endocrinol 19:812-23. 2005
  9. ncbi Evidence for a role of caveolin-1 in neurokinin-1 receptor plasma-membrane localization, efficient signaling, and interaction with beta-arrestin 2
    Valentina Kubale
    Institute of Anatomy, Histology and Embryology, Veterinary Faculty, University of Ljubljana, Gerbiceva 60, SI 1000, Ljubljana, Slovenia
    Cell Tissue Res 330:231-45. 2007
  10. pmc Biased signaling of the angiotensin II type 1 receptor can be mediated through distinct mechanisms
    Marie Mi Bonde
    Laboratory for Molecular Cardiology, The Danish National Research Foundation Centre for Cardiac Arrhythmia, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, and The Danish National Research Foundation Centre for Cardiac Arrhythmia, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 5:e14135. 2010

Research Grants

  1. Regulation of Drosophila arrestins in light adaptation
    Bih Hwa Shieh; Fiscal Year: 2012
  2. Arrestins in TLR4 Signaling in Macrophages
    Narayanan Parameswaran; Fiscal Year: 2013
  3. Vsevolod V Gurevich; Fiscal Year: 2015
  4. Regulation of Cardiac Adrenergic Function by S-nitrosylation
    JONATHAN STAMLER; Fiscal Year: 2009
  5. Mechanisms of sodium transport regulation in cystic fibrosis
    Thomas J Kelley; Fiscal Year: 2011
  6. Quan Lu; Fiscal Year: 2016
  7. RHODOPSIN TOPOGRAPHY IN THE ROD DISC MEMBRANE
    W Clay Smith; Fiscal Year: 2010
  8. Metallothionein & Cadmium Carcinogenesis in the Prostate
    Shuk Mei Ho; Fiscal Year: 2006
  9. Opioid-Induced Somatic Effects in Betaarrestin2-KO Mice
    KIRSTEN RAEHAL; Fiscal Year: 2007
  10. REGULATION OF PTH ACTIVITY IN BONE BY BETA-ARRESTIN
    Mary Bouxsein; Fiscal Year: 2004

Detail Information

Publications213 found, 100 shown here

  1. pmc Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor 1 (CB1)
    Kwang H Ahn
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269, USA
    J Biol Chem 288:9790-800. 2013
    ..These results demonstrate for the first time the involvement of β-arrestin in CB1-biased signaling by a CB1 allosteric modulator and also define the differential role of the two β-arrestin isoforms in CB1 signaling and internalization...
  2. doi Molecular mechanisms involved in activity of h7C10, a humanized monoclonal antibody, to IGF-1 receptor
    Matthieu Broussas
    Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, BP 60497, Saint Julien en Genevois, France
    Int J Cancer 124:2281-93. 2009
    ..Thus, we demonstrated that antitumoral properties of h7C10 are the result of IGF-1-induced cell signaling inhibition and down-regulation of IGF-1R level suggesting that h7C10 could be a candidate for therapeutic applications...
  3. pmc β-Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma
    Huiyuan Zheng
    Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet and Karolinska University Hospital, 17176 Stockholm, Sweden
    Proc Natl Acad Sci U S A 109:20620-5. 2012
    ..Defining and suppressing such biased signaling represents a practical therapeutic strategy to enhance response to anti-IGF-1R therapies...
  4. ncbi Gravin-mediated formation of signaling complexes in beta 2-adrenergic receptor desensitization and resensitization
    F Lin
    Department of Molecular Pharmacology, Diabetes and Metabolic Diseases Research Program, University Medical Center, State University of New York, Stony Brook, New York 11794 8651, USA
    J Biol Chem 275:19025-34. 2000
    ..These data reveal that gravin-mediated formation of signaling complexes with protein kinases/phosphatases, beta-arrestin, and clathrin is essential in agonist-induced internalization and resensitization of G-protein-linked receptors...
  5. ncbi Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein-coupled receptor trafficking
    You Me Kim
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    J Biol Chem 277:30760-8. 2002
    ..These mutants should prove useful in better defining the role of arrestins in mediating receptor trafficking...
  6. pmc Multiple scaffolding functions of {beta}-arrestins in the degradation of G protein-coupled receptor kinase 2
    Laura Nogués
    Departamento de Biologia Molecular and Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Biol Chem 286:1165-73. 2011
    ..The ability of β-arrestins to play different scaffold functions would allow coordination of both Mdm2-dependent and -independent processes aimed at the specific modulation of GRK2 turnover in different signaling contexts...
  7. ncbi Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling
    Yaya Wang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    Nat Immunol 7:139-47. 2006
    ..Thus, beta-arrestins are essential negative regulators of innate immune activation via TLR-IL-1R signaling...
  8. ncbi Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype
    Rasmus Jorgensen
    7TM Pharma A S, Horsholm, DK 2970, Denmark
    Mol Endocrinol 19:812-23. 2005
    ..G protein-coupled receptors, we constructed fusion proteins between the glucagon-like peptide 1 receptor and (beta)arr2. The fusion constructs had an increase in apparent affinity selectively for glucagon, suggesting that (beta)arr2 ..
  9. ncbi Evidence for a role of caveolin-1 in neurokinin-1 receptor plasma-membrane localization, efficient signaling, and interaction with beta-arrestin 2
    Valentina Kubale
    Institute of Anatomy, Histology and Embryology, Veterinary Faculty, University of Ljubljana, Gerbiceva 60, SI 1000, Ljubljana, Slovenia
    Cell Tissue Res 330:231-45. 2007
    ..Evidence was also obtained that the proper clustering of the receptor in these microdomains was important for effective agonist-induced NK1-R signaling and for its interaction with beta-arrestin2...
  10. pmc Biased signaling of the angiotensin II type 1 receptor can be mediated through distinct mechanisms
    Marie Mi Bonde
    Laboratory for Molecular Cardiology, The Danish National Research Foundation Centre for Cardiac Arrhythmia, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, and The Danish National Research Foundation Centre for Cardiac Arrhythmia, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 5:e14135. 2010
    ....
  11. doi Beta-arrestin2 as a competitor for GRK2 interaction with the GLP-1 receptor upon receptor activation
    Rasmus Jorgensen
    Hagedorn Research Institute, Måløv, Denmark
    Pharmacology 88:174-81. 2011
    ..report, we have analyzed the interaction pattern between the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R), βarr2, and GRK2 using bioluminescence resonance energy transfer assays...
  12. pmc TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells
    K Mythreye
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Oncogene 32:1416-27. 2013
    ....
  13. pmc ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7 receptor
    Ying Hong Feng
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Am J Physiol Cell Physiol 288:C1342-56. 2005
    ....
  14. ncbi Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia
    M Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan
    Genes Brain Behav 6:107-12. 2007
    ..One important molecule related to this cascade is beta-arrestin 2 (ARRB2)...
  15. pmc The beta-arrestin-2 scaffold protein promotes c-Jun N-terminal kinase-3 activation by binding to its nonconserved N terminus
    Chun Guo
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Biol Chem 283:15903-11. 2008
    ..These findings uncover molecular determinants of beta-arrestin-2 scaffold complex assembly and assign a previously unrecognized role for the unique extended N terminus of JNK3...
  16. doi The coding-synonymous polymorphism rs1045280 (Ser280Ser) in beta-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia
    Y J Liou
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    Eur J Neurol 15:1406-8. 2008
    ..delayed; therefore, the development of TD may be associated with mediators or signalling complexes behind DRD2, such as beta-arrestin 2 (ARRB2), an important mediator between DRD2 and serine-threonine protein kinase (AKT) signal cascade.
  17. doi β-arrestin-2 is expressed in human prostate smooth muscle and a binding partner of α1A-adrenoceptors
    Martin Hennenberg
    Department of Urology, Ludwig Maximilians University, Munich, Germany
    World J Urol 29:157-63. 2011
    ..Here, we investigated the expression and α1A-adrenoceptor binding of β-arrestin-2 in the human prostate...
  18. pmc Phosphorylation of C3a receptor at multiple sites mediates desensitization, β-arrestin-2 recruitment and inhibition of NF-κB activity in mast cells
    Kshitij Gupta
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS ONE 7:e46369. 2012
    ..C3aR possesses ten potential phosphorylation sites within its carboxyl terminus but their role on desensitization, β-arrestin recruitment and NF-κB activation has not been determined...
  19. ncbi Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2
    Lan Ge
    Division of Biomedical Sciences, Biochemical and Molecular Biology Program and Cellular, Molecular and Developmental Biology Program, University of California, Riverside, CA 92521, USA
    J Biol Chem 279:55419-24. 2004
    ....
  20. ncbi beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis
    A Claing
    Howard Hughes Medical Institute and Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:42509-13. 2001
    ....
  21. ncbi Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling
    Wei Chen
    Howard Hughes Medical Institute, Duke University Medical Center, Departments of Medicine and Biochemistry, Durham, NC 27710, USA
    Science 301:1394-7. 2003
    ..Thus, the regulatory actions of beta-arrestins are broader than previously appreciated, extending to the TGF-beta receptor family as well...
  22. pmc β-arrestin 2 regulates Toll-like receptor 4-mediated apoptotic signalling through glycogen synthase kinase-3β
    Hui Li
    Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Immunology 130:556-63. 2010
    ....
  23. pmc Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4
    Rohit Malik
    Program in Molecular Biology and Department of Pharmacology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    Mol Biol Cell 21:2529-41. 2010
    ..Our data suggest a mechanism whereby arrestin-2 via its interaction with STAM-1 modulates CXCR4 sorting by regulating the ubiquitination status of HRS...
  24. ncbi Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors
    Fang Tsyr Lin
    Howard Hughes Medical Institute and Departments of Medicine and Biochemistry, Duke University Medical Center, Box 3821, Durham, NC 27710, USA
    Biochemistry 41:10692-9. 2002
    ..Thus it appears that the function of all arrestin family members in mediating internalization of G protein-coupled receptors is regulated by distinct phosphorylation/dephosphorylation mechanisms...
  25. ncbi Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2
    Wei Chen
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Science 306:2257-60. 2004
    ..A Smo agonist stimulated and a Smo antagonist (cyclopamine) inhibited both phosphorylation of Smo by GRK2 and interaction of beta-arrestin 2 with Smo. beta-Arrestin 2 and GRK2 are thus potential mediators of signaling by activated Smo...
  26. ncbi Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis
    Dacia L Hunton
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Box 3821, Duke University Medical Center, Durham, NC 27710, USA
    Mol Pharmacol 67:1229-36. 2005
    ..These data suggest that beta-arrestin 2 can mediate chemotaxis through mechanisms which may be G-protein-independent (Ang II receptors) or -dependent (LPA receptors)...
  27. ncbi Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation
    Alexandre Rey
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospital, 1211 Geneva 14, Switzerland
    J Biol Chem 281:38181-8. 2006
    ....
  28. ncbi Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2
    Maria Zoudilova
    Cell, Molecular, and Developmental Biology Program and Biomedical Sciences Division, University of California Riverside, B605 Statistics Road, Riverside, CA 92521, USA
    J Biol Chem 282:20634-46. 2007
    ..These findings identify cofilin as a novel target of beta-arrestin-dependent scaffolding and suggest that many PAR-2-induced processes may be independent of Galpha(q/11) protein coupling...
  29. ncbi beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation
    William G Barnes
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:8041-50. 2005
    ....
  30. doi beta-Arrestins facilitate ubiquitin-dependent degradation of apoptosis signal-regulating kinase 1 (ASK1) and attenuate H2O2-induced apoptosis
    Zhengping Zhang
    Jiangsu Province Key Laboratory for Molecular and Medicine Biotechnology, College of Life Science, Nanjing Normal University, No 1 Wenyuan Road, Nanjing, Jiangsu, PR China
    Cell Signal 21:1195-206. 2009
    ....
  31. ncbi Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family
    H Attramadal
    Howard Hughes Medical Research Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 267:17882-90. 1992
    ..Furthermore, immunoelectron microscopy shows that the beta-arrestins are appropriately situated at postsynaptic sites to act in concert with beta ARK to regulate G protein-coupled neurotransmitter receptors...
  32. ncbi A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation
    L S Barak
    Howard Hughes Medical Institute Laboratories and Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 272:27497-500. 1997
    ....
  33. ncbi G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization
    R J Lefkowitz
    Departments of Medicine Cardiology and Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 273:18677-80. 1998
  34. pmc The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis
    S A Laporte
    Howard Hughes Medical Institute Laboratories and Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 96:3712-7. 1999
    ..These findings point to a role for AP-2 in GPCR endocytosis, and they suggest that AP-2 functions as a clathrin adaptor for the endocytosis of diverse classes of membrane receptors...
  35. ncbi Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3
    P H McDonald
    Howard Hughes Medical Institute and Department of Medicine, Duke University Medical Center, Box 3821, Durham, NC 27710, USA
    Science 290:1574-7. 2000
    ..Thus, beta-arrestin 2 acts as a scaffold protein, which brings the spatial distribution and activity of this MAPK module under the control of a GPCR...
  36. pmc Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds
    L M Luttrell
    The Geriatrics Research, Education and Clinical Center, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA
    Proc Natl Acad Sci U S A 98:2449-54. 2001
    ..These data suggest that beta-arrestins function both as scaffolds to enhance cRaf-1 and MEK-dependent activation of ERK2, and as targeting proteins that direct activated ERK to specific subcellular locations...
  37. ncbi Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*
    R H Oakley
    Howard Hughes Medical Institute Laboratories, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:19452-60. 2001
    ....
  38. ncbi Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin
    S Hilairet
    Departement de Biochimie, Universite de Montreal, Montreal, Quebec, H3C 3J7, Canada
    J Biol Chem 276:42182-90. 2001
    ..These results therefore indicate that although atypical by its heterodimeric composition and its targeting to the plasma membrane, the CGRP receptor shares endocytotic mechanisms that are common to most classical 7TM receptors...
  39. ncbi Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin
    S K Shenoy
    Howard Hughes Medical Institute and Department of Medicine, Duke University Medical Center, Box 3821, Durham, NC 27710, USA
    Science 294:1307-13. 2001
    ....
  40. ncbi Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization
    Moshmi Bhattacharya
    Cell Biology Research Group, The John P Robarts Research Institute, The University of Western Ontario, 100 Perth Drive, London, Ontario, N6A 5K8, Canada
    Nat Cell Biol 4:547-55. 2002
    ..Thus, beta-arrestins regulate multiple steps in the Ral-dependent processes that result in chemoattractant-induced cytoskeletal reorganization...
  41. ncbi Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation
    Yue Sun
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, People s Republic of China
    J Biol Chem 277:49212-9. 2002
    ....
  42. ncbi Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination
    Sudha K Shenoy
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:14498-506. 2003
    ..Thus the ubiquitination status of beta-arrestin determines the stability of the receptor-beta-arrestin complex as well as the trafficking pattern of beta-arrestin...
  43. pmc Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference
    Seungkirl Ahn
    The Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 100:1740-4. 2003
    ..This approach should allow discovery of novel signaling and regulatory roles for the beta-arrestins in many seven-membrane-spanning receptor systems...
  44. pmc Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
    Huijun Wei
    Howard Hughes Medical Institute and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 100:10782-7. 2003
    ..These findings imply the existence of independent G protein- and beta-arrestin 2-mediated pathways leading to ERK1/2 activation and the existence of distinct "active" conformations of a seven-membrane-spanning receptor coupled to each...
  45. ncbi Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4
    Wei Chen
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Science 301:1391-4. 2003
    ..These findings provide a previously unrecognized mechanism for receptor recruitment of beta-arrestin and demonstrate that Dvl plays an important role in the endocytosis of frizzled, as well as in promoting signaling...
  46. ncbi Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways
    Hua Gao
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, People s Republic of China
    Mol Cell 14:303-17. 2004
    ..Taken together, the current study may present a novel mechanism for regulation of the immune system by the sympathetic nervous system...
  47. ncbi Arrestin regulates MAPK activation and prevents NADPH oxidase-dependent death of cells expressing CXCR2
    Ming Zhao
    Division of Cancer Biology, La Jolla Institute for Molecular Medicine, San Diego, California 92121, USA
    J Biol Chem 279:49259-67. 2004
    ..These results indicate a novel function for arrestin, which is protection from an excessive oxidative burst, resulting from the sustained stimulation of G-protein-coupled receptors that cause Rac translocation...
  48. ncbi Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:15315-24. 2005
    ....
  49. ncbi Real-time monitoring of ubiquitination in living cells by BRET
    Julie Perroy
    Département de Biochimie and Groupe de Recherche sur le Système Nerveux Autonome, Universite de Montreal, C P 6128 Succursale Centre Ville Montréal, Quebec H3C 3J7, Canada
    Nat Methods 1:203-8. 2004
    ..The ubiquitination BRET assay should prove to be a useful tool for studying the dynamic ubiquitination of proteins and for understanding which cellular functions are regulated by this post-translational event...
  50. ncbi {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase
    Leonard Girnita
    Department of Oncology and Pathology, Division of Cellular and Molecular Tumor Pathology, Cancer Center Karolinska, R8 04, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    J Biol Chem 280:24412-9. 2005
    ..To our knowledge this is the first study demonstrating a defined molecular role of beta-arrestin with direct relevance to cell growth and cancer...
  51. ncbi An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 122:261-73. 2005
    ....
  52. pmc Beta-arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-kappaB activation
    Bing Luan
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    EMBO J 24:4237-46. 2005
    ..Thus, beta-arrestin2 is identified as a phosphorylation-regulated suppressor of UV response and this may play a functional role in the response of epidermal cells to UV...
  53. ncbi A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription
    Jiuhong Kang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Graduate School, Chinese Academy of Sciences, Shanghai 200031, China
    Cell 123:833-47. 2005
    ....
  54. pmc Functional specialization of beta-arrestin interactions revealed by proteomic analysis
    Kunhong Xiao
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:12011-6. 2007
    ..This study provides a comprehensive analysis of proteins that bind beta-arrestin isoforms and underscores their potentially broad regulatory roles in mammalian cellular physiology...
  55. ncbi Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4
    Deepali Bhandari
    Department of Pharmacology and Experimental Therapeutics, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    J Biol Chem 282:36971-9. 2007
    ..Taken together, our data suggest that the AIP4.arrestin-2 complex functions on endosomes to regulate sorting of CXCR4 into the degradative pathway...
  56. ncbi Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcription
    Mi Hye Lee
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 283:2088-97. 2008
    ....
  57. pmc Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 283:22166-76. 2008
    ..Collectively, our findings indicate that the degradative fate of the beta(2)AR in the lysosomal compartments is dependent upon beta-arrestin2-mediated recruitment of Nedd4 to the activated receptor and Nedd4-catalyzed ubiquitination...
  58. doi Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance
    Bing Luan
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, and Graduate School of the Chinese Academy of Sciences
    Nature 457:1146-9. 2009
    ..Our findings provide new insight into the molecular pathogenesis of insulin resistance, and implicate new preventive and therapeutic strategies against insulin resistance and type 2 diabetes...
  59. pmc {beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
    Seungkirl Ahn
    Departments of Medicine and Biochemistry and Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 284:8855-65. 2009
    ..These findings establish a key role for beta-arrestin-2 in mediating cellular cytoprotective functions by a 7-transmembrane receptor and define the biochemical pathways involved...
  60. ncbi beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4
    Z J Cheng
    Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    J Biol Chem 275:2479-85. 2000
    ....
  61. ncbi Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2
    Aylin C Hanyaloglu
    7TM Receptor Laboratory, Western Australian Institute for Medical Research WAIMR, University of Western Australia, Centre for Medical Research, Nedlands, Perth, WA 6009, Australia
    J Biol Chem 277:50422-30. 2002
    ..This study demonstrates that TRHR subtypes are differentially regulated by the beta-arrestins and also provides the first evidence that the interactions of TRHRs with beta-arrestin may be altered by hetero-oligomer formation...
  62. ncbi The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation
    Akira Tohgo
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:6258-67. 2003
    ....
  63. ncbi Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2
    Ping Wang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, People s Republic of China
    J Biol Chem 278:6363-70. 2003
    ..Our study thus suggests that beta-arrestin 2 may serve as a cross-talk linker between GPCR and p53 signaling pathways...
  64. ncbi Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus
    Ping Wang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    J Biol Chem 278:11648-53. 2003
    ....
  65. ncbi Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2
    Seungkirl Ahn
    Howard Hughes Medical Institute, Department of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:7807-11. 2004
    ....
  66. ncbi Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77
    Susana Castro-Obregon
    Buck Institute for Age Research, Novato, California 94945 1400, USA
    J Biol Chem 279:17543-53. 2004
    ..These results suggest that Nur77, which is regulated by a MAPK pathway activated via arrestin 2, modulates NK(1)R-mediated nonapoptotic pcd...
  67. ncbi Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2
    Huijun Wei
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:48255-61. 2004
    ..These findings demonstrate how the ability of receptors to interact with beta-arrestins determines both the mechanism of ERK activation as well as the physiological consequences of this activation...
  68. ncbi Preferential Interaction between the dopamine D2 receptor and Arrestin2 in neostriatal neurons
    Tara A Macey
    Department of Behavioral Neuroscience, Oregon Health and Science University and Veterans Affairs Medical Center, Portland, Oregon 97239 2999, USA
    Mol Pharmacol 66:1635-42. 2004
    ..All three measures of receptor/arrestin interaction (colocalization, translocation, and coprecipitation) demonstrated selective agonist-induced interaction between the D2 receptor and arrestin2 in neurons...
  69. pmc beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform
    Elod Z Szabo
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 102:2790-5. 2005
    ..Comparable results were also obtained for the beta-arrestin1 isoform. These data reveal a broader role for arrestins in the trafficking of integral plasma membrane proteins than previously recognized...
  70. ncbi The human thyrotropin receptor is predominantly internalized by beta-arrestin 2
    Romy Frenzel
    III Medical Department, University of Leipzig, 04103 Leipzig, Germany
    Endocrinology 147:3114-22. 2006
    ....
  71. ncbi Opposing effects of beta-arrestin1 and beta-arrestin2 on activation and degradation of Src induced by protease-activated receptor 1
    Fang Ting Kuo
    Institute of Molecular and Cellular Biology, Hsinchu 30013, Taiwan ROC
    Cell Signal 18:1914-23. 2006
    ..beta-Arrestin2 also appears to promote PAR1-induced degradation of Src. This degradation of Src provides a possible mechanism for terminating PAR1 signaling...
  72. pmc Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins
    Benjamin E Padilla
    Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 179:981-97. 2007
    ..We propose a mechanism by which endosomal ECE-1 degrades neuropeptides in endosomes to disrupt the peptide/receptor/beta-arrestin complex, freeing internalized receptors from beta-arrestins and promoting recycling and resensitization...
  73. doi A beta-arrestin 2 signaling complex mediates lithium action on behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Duke University Medical Center, Durham, NC, USA
    Cell 132:125-36. 2008
    ..These results point toward a pharmacological approach to modulating GPCR function that affects the formation of beta-arrestin-mediated signaling complexes...
  74. pmc Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells
    Noriyuki Sonoda
    Department of Medicine, Division of Endocrinology and Metabolism, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:6614-9. 2008
    ..Taken together, these studies indicate that beta-arrestin-1 plays a role in GLP-1 signaling leading to insulin secretion, defining a previously undescribed mechanism for GLP-1 action...
  75. pmc Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Box 3821, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 106:6650-5. 2009
    ..Thus, USP33-beta-arrestin interaction is a key regulatory step in 7TMR trafficking and signal transmission from the activated receptors to downstream effectors...
  76. pmc Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling
    Graeme S Cottrell
    Department of Surgery, University of California, San Francisco, CA 94143 0660, USA
    J Biol Chem 284:22411-25. 2009
    ..We propose that agonist availability in endosomes, here regulated by ECE-1, controls beta-arrestin-dependent signaling of endocytosed GPCRs...
  77. pmc Imaging ligand-dependent activation of CXCR7
    Kathryn E Luker
    Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Neoplasia 11:1022-35. 2009
    ....
  78. pmc Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells
    Arpana Vibhuti
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e19585. 2011
    ..The role of β-arrestins on C3aR activation/regulation in human mast cells, however, remains unknown...
  79. pmc beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53
    Cedric Boularan
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, 75014 Paris, France
    Proc Natl Acad Sci U S A 104:18061-6. 2007
    ..interaction with and subsequent titration out of the nucleus of the protooncogene Mdm2 specifically require beta-arr2 oligomers together with the previously characterized nucleocytoplasmic shuttling of beta-arr2...
  80. ncbi The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation
    Jennifer L Estall
    Departments of Laboratory Medicine and Pathobiology, and Medicine, University of Toronto, The Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, Toronto M5G 2C4, Canada
    J Biol Chem 280:22124-34. 2005
    ....
  81. ncbi Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes
    J L DeGraff
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 274:11253-9. 1999
    ..However, endocytosis does not appear to be required for alpha2-adrenergic, epidermal growth factor, lysophosphatidic acid, or beta2-adrenergic receptor-mediated p42/p44 MAP kinase activation in COS-1 cells...
  82. ncbi Metabotropic glutamate receptor 1 internalization induced by muscarinic acetylcholine receptor activation: differential dependency of internalization of splice variants on nonvisual arrestins
    Stuart J Mundell
    Department of Pharmacology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    Mol Pharmacol 61:1114-23. 2002
    ..This study demonstrates that the internalization of mGluR1 splice variants is subject to PKC and CaMKII regulation. In addition, regulation by these kinases confers differential arrestin dependence...
  83. ncbi Studies of Rh1 metarhodopsin stabilization in wild-type Drosophila and in mutants lacking one or both arrestins
    A Kiselev
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biochemistry 36:2188-96. 1997
    ..recovered in flies deficient in arrestin-1 (arr1(1) mutant), approximately 38% in flies deficient in arrestin-2 (arr2(3) mutant), and approximately 6% in flies deficient in both arrestin-1 and arrestin-2 (arr1(1), arr2(3) double ..
  84. ncbi N-formyl peptide receptors internalize but do not recycle in the absence of arrestins
    Charlotte M Vines
    Department of Cell Biology and Physiology, The University of New Mexico Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    J Biol Chem 278:41581-4. 2003
    ..stably expressed the FPR in a mouse embryonic fibroblast cell line (MEF) that lacked endogenous arrestin 2 and arrestin 3 (arrestin-deficient)...
  85. ncbi The interaction of a constitutively active arrestin with the arrestin-insensitive 5-HT(2A) receptor induces agonist-independent internalization
    John A Gray
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4935, USA
    Mol Pharmacol 63:961-72. 2003
    ..We show here that this "constitutively active" arrestin mutant (Arr2-R169E) can force 5-HT(2A) receptors to be regulated by arrestins...
  86. ncbi Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding
    Shawn K Milano
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 281:9812-23. 2006
    ..Thus, by promoting cytosolic oligomerization, IP(6) binding is proposed to be a negative regulator of interactions of arrestin with plasma membrane and nuclear signaling proteins...
  87. pmc A role for the light-dependent phosphorylation of visual arrestin
    P G Alloway
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 96:6072-7. 1999
    ..The major arrestin in the Drosophila visual system, Arrestin 2 (Arr2), is phosphorylated in a light-dependent manner by a Ca2+/calmodulin-dependent protein kinase and has been shown to ..
  88. ncbi Identification of a short linear sequence present in the C-terminal tail of the rat follitropin receptor that modulates arrestin-3 binding in a phosphorylation-independent fashion
    Hiroshi Kishi
    Department of Pharmacology, The University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 277:21939-46. 2002
    ..We conclude that a short linear sequence present in the C-terminal tail of the rFSHR (642SATHNFHARK651) that is not phosphorylated limits internalization by lowering the affinity of the rFSHR for the endogenous non-visual arrestins...
  89. pmc Arrestin-3 is essential for the activation of Fyn by the luteinizing hormone receptor (LHR) in MA-10 cells
    Colette Galet
    Department of Pharmacology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Cell Signal 20:1822-9. 2008
    ..These results show that, in MA-10 cells, the hLHR activates Fyn through an arrestin-3-dependent pathway and that this pathway is a mediator of the hLHR-provoked release of EGF-like growth factors...
  90. ncbi Characterization of dominant negative arrestins that inhibit beta2-adrenergic receptor internalization by distinct mechanisms
    M J Orsini
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 273:34616-22. 1998
    ....
  91. pmc beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
    T A Kohout
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 98:1601-6. 2001
    ..prepared mouse embryonic fibroblasts from knockout mice that lack one of the beta-arrestins (beta arr1-KO and beta arr2-KO) or both (beta arr1/2-KO), as well as their wild-type (WT) littermate controls...
  92. ncbi Activation-dependent conformational changes in {beta}-arrestin 2
    Kunhong Xiao
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 279:55744-53. 2004
    ..Here we characterize the conformational changes in beta-arrestin 2 (arrestin 3) by comparing the limited tryptic proteolysis patterns and matrix-assisted laser desorption/ionization-time of ..
  93. pmc beta-Arrestins modulate Adenovirus-vector-induced innate immune responses: differential regulation by beta-arrestin-1 and beta-arrestin-2
    Sergey S Seregin
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, United States
    Virus Res 147:123-34. 2010
    ..The G-protein-coupled receptor adaptors beta-arrestin-1 (beta-Arr1) and beta-arrestin-2 (beta-Arr2) are known to have pivotal roles in regulating TLR4 triggered signaling and inflammatory responses...
  94. ncbi Arrestin function in inactivation of G protein-coupled receptor rhodopsin in vivo
    P J Dolph
    Howard Hughes Medical Institute, La Jolla, CA
    Science 260:1910-6. 1993
    ..Analysis of the light response in these mutants shows that the Arr1 and Arr2 proteins are mediators of rhodopsin inactivation and are essential for the termination of the phototransduction ..
  95. pmc beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 20:635-43. 2005
    ..These data indicate that arrestin-mediated regulation of intracellular signaling contributes to the differential effects of PTH at endosteal and periosteal bone surfaces...
  96. ncbi Arrestin1 mediates light-dependent rhodopsin endocytosis and cell survival
    Akiko K Satoh
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Curr Biol 15:1722-33. 2005
    ..and rdgC mutants, endocytosis of abnormally stable complexes of rhodopsin (Rh1) and fly photoreceptor Arrestin2 (Arr2) triggers cell death, implicating Rh1/Arr2-bearing endosomes in pro-cell death signaling, potentially via arrestin-..
  97. doi Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages
    Katie Loniewski
    Department of Physiology, Division of Pathology, Michigan State University, East Lansing, MI 48824, USA
    Mol Immunol 45:2312-22. 2008
    ..We demonstrate here that activation of TLR2 and 4 (but not TLR3 and 7) significantly decrease ARR2 but not ARR3 protein levels in macrophages...
  98. ncbi Isolation of a novel visual-system-specific arrestin: an in vivo substrate for light-dependent phosphorylation
    H Levine
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093
    Mech Dev 33:19-25. 1990
    ..the protein was determined by isolating the corresponding gene, which revealed it to be a new isoform of arrestin, Arr2. Arr2 is 401 residues in length, and shares 47% sequence identity with the Drosophila Arr1 protein and 42% with ..
  99. pmc A functional role for Anopheles gambiae Arrestin1 in olfactory signal transduction
    William B Walker
    Department of Biological Sciences, Centers for Molecular Neuroscience and Global Health and Programs in Development, Genetics Vanderbilt University, Nashville, TN 37232, USA
    J Insect Physiol 54:680-90. 2008
    ..transduction pathways, as evidenced by the phenotypic effects of mutations in the genes encoding both Arr1 and Arr2 in Drosophila melanogaster...
  100. ncbi Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling
    Snehal Naik
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 280:8722-32. 2005
    ..These findings characterized the CysLT1R as the first G protein-coupled receptor identified to date in which PKC is the principal regulator of both rapid agonist-dependent internalization and rapid agonist-dependent desensitization...
  101. pmc Regulation of amygdalar PKA by beta-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning
    Yuting Li
    The State Key Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai 200032, China
    Proc Natl Acad Sci U S A 106:21918-23. 2009
    ..b>Arrb2(-/-) mice exhibit impaired conditioned fear memory and long-term potentiation at the lateral amygdalar synapses...

Research Grants23

  1. Regulation of Drosophila arrestins in light adaptation
    Bih Hwa Shieh; Fiscal Year: 2012
    ..In Drosophila photoreceptors, there are two distinct arrestin homologues, Arr1 and Arr2. Studies support that Arr1 promotes endocytosis of rhodopsin, whereas Arr2 is required for fast deactivation of the ..
  2. Arrestins in TLR4 Signaling in Macrophages
    Narayanan Parameswaran; Fiscal Year: 2013
    ..Recent studies have demonstrated a critical role for non-visual arrestins (ARR2 and ARR3) in the regulation of TLR signaling and pathophysiology...
  3. Vsevolod V Gurevich; Fiscal Year: 2015
    ..Molecular toos that specifically increase or block pro-apoptotic signaling have therapeutic potential in disorders associated with excessive cell proliferation (e.g., cancer) or death (e.g., neurodegenerative diseases). ..
  4. Regulation of Cardiac Adrenergic Function by S-nitrosylation
    JONATHAN STAMLER; Fiscal Year: 2009
    ..In particular, we have recently identified the ?-arrestins (?arr1 and ?arr2) as targets of ?-AR-coupled S- nitrosylation by NO synthases (eNOS and nNOS)...
  5. Mechanisms of sodium transport regulation in cystic fibrosis
    Thomas J Kelley; Fiscal Year: 2011
    ..This proposal hypothesizes that alterations in chronic cAMP signaling in CF airway epithelial cells increases sodium transport through modulating membrane cholesterol levels. ..
  6. Quan Lu; Fiscal Year: 2016
    ....
  7. RHODOPSIN TOPOGRAPHY IN THE ROD DISC MEMBRANE
    W Clay Smith; Fiscal Year: 2010
    ..Understanding how these mutations affect the function of the protein will help direct the development of therapeutic interventions for diseases that result from arrestin defects. ..
  8. Metallothionein & Cadmium Carcinogenesis in the Prostate
    Shuk Mei Ho; Fiscal Year: 2006
    ..and d) We have generated a prostate-specific, MT-I overexpresser using a third generation probasin (PB) promoter, ARR2, to target MT-1 expression...
  9. Opioid-Induced Somatic Effects in Betaarrestin2-KO Mice
    KIRSTEN RAEHAL; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Beta-arrestin2-knockout (Beta-arr2-KO) mice display enhanced morphine-induced biological effects such as analgesia, while other responses like constipation are attenuated when compared to ..
  10. REGULATION OF PTH ACTIVITY IN BONE BY BETA-ARRESTIN
    Mary Bouxsein; Fiscal Year: 2004
    ..We demonstrated that a cytoplasmic molecule, Beta-arrestin2 (beta-arr2), regulates the activity of PTH1R and its agonists in vitro by promoting rapid endocytosis of ligand--receptor ..
  11. TRAINING PROGRAM IN MOLECULAR CELL BIOLOGY OF CANCER
    James Keen; Fiscal Year: 2003
    ..The goal of this Program is to develop highly trained, technically competent research scientists capable of performing and eventually directing research in the molecular cell biology of cancer. ..
  12. Glenn W Stevenson; Fiscal Year: 2014
    ..This strategy will complement the more traditional procedures for assessing pain and antinociceptive activity, and help in the development of safer and more effective treatments for chronic pain. [unreadable] [unreadable] [unreadable]..
  13. Trafficking and signaling of opioid receptor subtypes and heterodimers
    Jennifer L Whistler; Fiscal Year: 2010
    ..Thus targeting these subtypes or heterodimers could provide improved therapeutic utility. ..
  14. MOLECULAR GENETICS OF PHOTOTRANSDUCTION
    Bih Hwa Shieh; Fiscal Year: 2006
    ..Un-regulated signaling may lead to hyperactivity or degeneration of neurons, which has been implicated in mans pathophysiological conditions such as epilepsy and neurodegenerative diseases. ..
  15. Bioimaging Facility Confocal Microscope
    James Keen; Fiscal Year: 2004
    ..Acquisition of the proposed instrument will allow these and other investigators to more effectively carry out their work, and to use and develop state-of-the-art techniques in confocal microscopy in their studies. ..
  16. E1A GENE THERAPY IN BREAST CANCER
    Mien Chie Hung; Fiscal Year: 2004
    ..3. To develop a tumor specific promoter using hTERT promoter-driven E1A for breast cancer gene therapy. 4. To develop E1A clinical trials for metastatic cancer patients. ..
  17. REGULATION OF THE CAMP SPECIFIC PHOSPHODIESTERASES
    Graeme Bolger; Fiscal Year: 2003
    ..5. The two-hybrid system will be used to clone cDNAs encoding proteins that interact with 4 novel PDE4 isoforms. ..
  18. Innovative Assays for Oncogenic Hedgehog Signaling
    Wei Chen; Fiscal Year: 2008
    ..In particular it should be possible to identify critical proteins modulating altered signaling pathways in pancreatic adenocarcinoma and design pharmacologic strategies to target them for therapeutic benefit. ..
  19. REGULATION OF PTH ACTIVITY IN BONE BY BETA-ARRESTIN
    Mary Bouxsein; Fiscal Year: 2008
    ..of this hypothesis, our preliminary data indicate that compared to wild-type (WT) mice, beta-arrestin2 null (beta-arr2-/-) mice have reduced bone mass and architecture, and importantly, an altered skeletal response to intermittent PTH ..
  20. GASP and Trafficking of the Dopamine Receptors
    Jennifer Whistler; Fiscal Year: 2007
    ..These studies will determine whether GPCR sorting can be manipulated both in vitro and in vivo. This may provide a new spectrum of therapeutic targets for the treatment of schizophrenia and depression. [unreadable] [unreadable]..
  21. Imaging Vaccina Viral-Host Pathogenesis
    Gary Luker; Fiscal Year: 2007
    ..Collectively, the research is expected to facilitate the development of improved vaccines and treatments for smallpox, thereby enhancing our ability to prevent the use of smallpox for bioterrorism. [unreadable] [unreadable] [unreadable]..
  22. Microcomputed Tomography Device (Scanco UCT40)
    Mary Bouxsein; Fiscal Year: 2004
    ..abstract_text> ..