aromatase

Summary

Gene Symbol: aromatase
Description: cytochrome P450 family 19 subfamily A member 1
Alias: ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM, aromatase, cytochrome P-450AROM, cytochrome P450 19A1, cytochrome P450, family 19, subfamily A, polypeptide 1, cytochrome P450, subfamily XIX (aromatization of androgens), estrogen synthase, estrogen synthetase, flavoprotein-linked monooxygenase, microsomal monooxygenase
Species: human

Top Publications

  1. doi Characterisation of aromatase expression in the human adipocyte cell line SGBS
    Kerry J McInnes
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Breast Cancer Res Treat 112:429-35. 2008
  2. pmc Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels
    Inga Peter
    Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    J Clin Endocrinol Metab 93:2779-85. 2008
  3. ncbi Aromatase--a brief overview
    Evan R Simpson
    Prince Henry s Institute of Medical Research and the Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia
    Annu Rev Physiol 64:93-127. 2002
  4. ncbi Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Cancer Res 67:1893-7. 2007
  5. pmc Interaction of soy food and tea consumption with CYP19A1 genetic polymorphisms in the development of endometrial cancer
    Wang Hong Xu
    Department of Epidemiology, Shanghai Cancer Institute and Cancer Institute of Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Am J Epidemiol 166:1420-30. 2007
  6. ncbi Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in Japanese women
    Noriko Kado
    Department of Obstetrics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Hum Reprod 17:897-902. 2002
  7. pmc Plasma estrone sulfate concentrations and genetic variation at the CYP19A1 locus in postmenopausal women with early breast cancer treated with letrozole
    G Lunardi
    Oncology Unit, Ospedale Sacro Cuore Don Calabria, Via Sempreboni, 5, 37024 Negrar, VR, Italy
    Breast Cancer Res Treat 137:167-74. 2013
  8. doi Tissue-specific regulation of aromatase promoter II by the orphan nuclear receptor LRH-1 in breast adipose stromal fibroblasts
    Ashwini L Chand
    Prince Henry s Institute, Monash Medical Centre, 246 Clayton Road, Clayton, Melbourne, VIC 3168, Australia
    Steroids 76:741-4. 2011
  9. pmc Follicle-stimulating hormone/cAMP regulation of aromatase gene expression requires beta-catenin
    Tehnaz N Parakh
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 103:12435-40. 2006
  10. pmc A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole
    Zaida Garcia-Casado
    Laboratory of Molecular Biology, Fundacion Instituto Valenciano de Oncologia, Valencia, Spain
    BMC Cancer 10:36. 2010

Research Grants

  1. MicroRNA Signature of Tamoxifen Resistance in Breast Cancer
    Sarmila Majumder; Fiscal Year: 2010
  2. Christopher Benz; Fiscal Year: 2014
  3. Erik Knudsen; Fiscal Year: 2014
  4. Diana M Cittelly; Fiscal Year: 2015
  5. VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2014
  6. Development of Breast Cancer Risk Model Based on Estrogen Metabolomics
    Richard J Santen; Fiscal Year: 2013
  7. Targeting endocrine resistant breast cancer with anacardic acid
    David Schultz; Fiscal Year: 2013
  8. Theranostic Nanomedicine for Breast Cancer Prevention and Image-Guided Therapy
    Prakash R Rai; Fiscal Year: 2011
  9. Prakash R Rai; Fiscal Year: 2014
  10. Mechanisms of Breast Tumor Cell Growth, Motility, and Antiestrogen Response
    Amy H Bouton; Fiscal Year: 2013

Detail Information

Publications286 found, 100 shown here

  1. doi Characterisation of aromatase expression in the human adipocyte cell line SGBS
    Kerry J McInnes
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Breast Cancer Res Treat 112:429-35. 2008
    b>Aromatase is a member of the cytochrome P450 superfamily of enzymes which catalyses the rate-limiting step in the biosynthesis of estrogens...
  2. pmc Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels
    Inga Peter
    Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    J Clin Endocrinol Metab 93:2779-85. 2008
    ..associations between variations in genes encoding estrogen receptors alpha (ESR1) and beta (ESR2), and enzyme aromatase (CYP19A1), which regulates the estrogen to testosterone ratio, and cardiovascular phenotypes in the Framingham ..
  3. ncbi Aromatase--a brief overview
    Evan R Simpson
    Prince Henry s Institute of Medical Research and the Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia
    Annu Rev Physiol 64:93-127. 2002
    ..These sites include breast, bone, vasculature, and brain. Within these sites, aromatase action can generate high levels of estradiol locally without significantly affecting circulating levels...
  4. ncbi Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Cancer Res 67:1893-7. 2007
    The CYP19A1 gene encodes the enzyme aromatase, which is responsible for the final step in the biosynthesis of estrogens...
  5. pmc Interaction of soy food and tea consumption with CYP19A1 genetic polymorphisms in the development of endometrial cancer
    Wang Hong Xu
    Department of Epidemiology, Shanghai Cancer Institute and Cancer Institute of Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Am J Epidemiol 166:1420-30. 2007
    Certain polyphenols inhibit the activity of aromatase, a critical enzyme in estrogen synthesis that is coded by the CYP19A1 gene...
  6. ncbi Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in Japanese women
    Noriko Kado
    Department of Obstetrics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Hum Reprod 17:897-902. 2002
    To investigate whether polymorphisms of CYP17 and CYP19 genes are associated with the risk of endometriosis, we analysed the frequency and distribution of a single nucleotide polymorphism at the 5' untranslated region of the CYP17 gene, ..
  7. pmc Plasma estrone sulfate concentrations and genetic variation at the CYP19A1 locus in postmenopausal women with early breast cancer treated with letrozole
    G Lunardi
    Oncology Unit, Ospedale Sacro Cuore Don Calabria, Via Sempreboni, 5, 37024 Negrar, VR, Italy
    Breast Cancer Res Treat 137:167-74. 2013
    Estrogen synthesis suppression induced by aromatase inhibitors in breast cancer (BC) patients may be affected by single nucleotide polymorphisms (SNPs) of the gene encoding aromatase enzyme, CYP19A1...
  8. doi Tissue-specific regulation of aromatase promoter II by the orphan nuclear receptor LRH-1 in breast adipose stromal fibroblasts
    Ashwini L Chand
    Prince Henry s Institute, Monash Medical Centre, 246 Clayton Road, Clayton, Melbourne, VIC 3168, Australia
    Steroids 76:741-4. 2011
    In postmenopausal breast cancers, the increase in aromatase expression observed in tumour associated adipose stromal cells is mediated via the upregulation of promoter II (PII) transcription...
  9. pmc Follicle-stimulating hormone/cAMP regulation of aromatase gene expression requires beta-catenin
    Tehnaz N Parakh
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 103:12435-40. 2006
    ..of estradiol in women are controlled by follicle-stimulating hormone (FSH), which regulates transcription of the aromatase gene (CYP19A1) in ovarian granulosa cells...
  10. pmc A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole
    Zaida Garcia-Casado
    Laboratory of Molecular Biology, Fundacion Instituto Valenciano de Oncologia, Valencia, Spain
    BMC Cancer 10:36. 2010
    b>Aromatase (CYP19A1) regulates estrogen biosynthesis. Polymorphisms in CYP19A1 have been related to the pathogenesis of breast cancer (BC)...
  11. ncbi Aromatase gene (CYP19A1) variants, female infertility and ovarian stimulation outcome: a preliminary report
    Signe Altmäe
    Department of Biotechnology, Institute of Molecular and Cell Biology, Estonian Genome Foundation, University of Tartu, Estonia
    Reprod Biomed Online 18:651-7. 2009
    Progress has been made towards ascertaining the genetic predictors of ovarian stimulation in IVF. Aromatase cytochrome P450, encoded by the CYP19A1 gene, catalyses a key step in ovarian oestrogen biosynthesis...
  12. doi Identification of CYP19A1 single-nucleotide polymorphisms and their haplotype distributions in a Korean population
    Su Jun Lee
    Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Inje University, Busan, South Korea
    J Hum Genet 55:189-93. 2010
    b>Aromatase, encoded by the CYP19A1 gene, is a key enzyme in the biosynthesis of estrogen. In an effort to screen for CYP19A1 single-nucleotide polymorphisms (SNPs) in Koreans, the CYP19A1 gene was directly sequenced in 50 normal subjects...
  13. doi SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients
    Xin Lin Zhang
    Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, PR China
    Mol Med Rep 5:245-9. 2012
    CYP19 encodes aromatase, a key enzyme essential for estrogen biosynthesis...
  14. pmc Variants in CYP17 and CYP19 cytochrome P450 genes are associated with onset of Alzheimer's disease in women with down syndrome
    Constance Chace
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
    J Alzheimers Dis 28:601-12. 2012
    CYP17 and CYP19 are involved in the peripheral synthesis of estrogens, and polymorphisms in CYP17 and CYP19 have been associated with increased risk of estrogen-related disorders...
  15. ncbi WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells
    Bilgin Gurates
    Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 87:4369-77. 2002
    ..SF-1) induces the expression of Müllerian inhibiting substance (MIS) and many steroidogenic genes, including aromatase P450 (P450arom)...
  16. doi Polymorphisms in estrogen related genes may modify the protective effect of isoflavones against prostate cancer risk in Japanese men
    Tomoko Sonoda
    Department of Public Health, Sapporo Medical University School of Medicine, Hokkaido, Japan
    Eur J Cancer Prev 19:131-7. 2010
    ..This study examined whether the genetic polymorphisms of estrogen receptors (ESR-alpha and ESR-beta) and cytochrome P450 19A1 (CYP19A1) modified the protective effect of isoflavones against prostate cancer...
  17. pmc Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1
    Christal D Sohl
    Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 285:17734-43. 2010
    b>Cytochrome P450 19A1 (P450 19A1), the aromatase, catalyzes the conversion of androgens to estrogens through a sequential three-step reaction, generating 19-hydroxy and 19-aldehyde intermediates en route to the product estrogen...
  18. doi In vitro kinetic properties of the Thr201Met variant of human aromatase gene CYP19A1: functional responses to substrate and product inhibition and enzyme inhibitors
    E J Payne
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Perth, Western Australia 6009
    J Clin Endocrinol Metab 94:2998-3002. 2009
    The T(201)M variant (rs28757184) within exon 5 of the human aromatase gene CYP19A1, present in up to 20% of some populations, has been reported to reduce prostate cancer progression.
  19. doi Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk
    Katie A Ashton
    Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Australia
    Cancer Epidemiol 34:328-37. 2010
    ..The environmental and reproductive risk factors that influence these hormones are well known, however, genetic variants involved in hormone biosynthesis and estrogen metabolism have not been well established in endometrial cancer...
  20. ncbi Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line
    Stefania Catalano
    Centro Sanitario and the Department of PharmacoBiology, Faculty of Pharmacy, University of Calabria, 87030 Arcavacata di Rende, Italy
    J Biol Chem 278:28668-76. 2003
    ..risk factor particularly in postmenopausal women, where estrogen production by adipose tissue through its own aromatase activity stimulates tumor progression...
  21. doi Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease
    Ikuko Mizuta
    Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine, 2 2 B9 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Hum Genet 124:89-94. 2008
    ..Our genetic analysis suggests that CALB1 is associated with PD independently of SNCA, and that FGF20 is associated with PD synergistically with SNCA...
  22. ncbi Novel exon 1 of the aromatase gene specific for aromatase transcripts in human brain
    S Honda
    Division of Molecular Genetics, Fujita Health University, Aichi, Japan
    Biochem Biophys Res Commun 198:1153-60. 1994
    b>Aromatase in the brain is supposed to participate in sexual differentiation of the brain...
  23. ncbi The expression and regulation of drug metabolism in human placenta
    - Pasanen
    Department of Pharmacology and Toxicology, University of Oulu, Kajaanintie 52 D, SF 90220 Oulu, Finland National Agency for Medicines, Helsinki, Finland
    Adv Drug Deliv Rev 38:81-97. 1999
    ..b>Aromatase, CYP19, and cholesterol side-chain cleaving, CYP11B, genes, proteins and activities are catalytically active in ..
  24. pmc Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: implications in atherosclerosis
    Tapan K Mukherjee
    Department of Obstetrics and Gynecology, University of California Los Angeles School of Medicine, Los Angeles, CA 90095 1740, USA
    Proc Natl Acad Sci U S A 99:4055-60. 2002
    ..whether testosterone inhibited TNFalpha-induced VCAM-1 expression via its conversion to estradiol by the enzyme aromatase in human umbilical vein endothelial cells (HUVEC)...
  25. ncbi WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells
    Bilgin Gurates
    Departments of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Illinois at Chicago, 820 S Wood Street, M C 808, Chicago, IL 60612, USA
    Mol Cell Endocrinol 208:61-75. 2003
    ..b>Aromatase P450 (P450arom) is the rate-limiting enzyme for estrogen formation...
  26. ncbi CYP1B1 and CYP19 gene polymorphisms and breast cancer incidence: no association in the ARIC study
    Bharat Thyagarajan
    School of Public Health, Division of Epidemiology, University of Minnesota, Minneapolis, MN 55454, USA
    Cancer Lett 207:183-9. 2004
    ..breast cancer and Val432Leu polymorphism in the CYP1B1 gene and the tetranucleotide repeats in intron 4 of the CYP19 gene...
  27. ncbi Association of aromatase (CYP 19) gene variation with features of hyperandrogenism in two populations of young women
    C J Petry
    Department of Paediatrics, University of Cambridge, Cambridge CB2 2QQ, UK
    Hum Reprod 20:1837-43. 2005
    b>Aromatase catalyses the conversion of androgens to estrogens and thus variation in the aromatase gene could contribute to female syndromes of androgen excess, such as precocious pubarche (PP) and polycystic ovarian syndrome (PCOS).
  28. ncbi The role of aromatase and 17-beta-hydroxysteroid dehydrogenase type 1 mRNA expression in predicting the clinical outcome of human breast cancer
    M Salhab
    St George s Hospital, Blackshaw Road, London, Tooting, UK
    Breast Cancer Res Treat 99:155-62. 2006
    ..The cytochrome P-450 aromatase enzyme complex is responsible for the conversion of C19 androgens to estrogens and 17-beta-hydroxysteroid ..
  29. ncbi Sex steroids and leptin regulate 11beta-hydroxysteroid dehydrogenase I and P450 aromatase expressions in human preadipocytes: Sex specificities
    Marie Noelle Dieudonne
    Service de Biochimie et de Biologie Moléculaire, UPRES EA 2493, Faculte de Medecine Paris Ile de France Ouest, Universite Versailles St Quentin, Centre Hospitalier de Poissy, 78303 Poissy Cedex, France
    J Steroid Biochem Mol Biol 99:189-96. 2006
    ..dehydrogenase (HSD1), the enzyme responsible for the conversion of cortisone into cortisol and the P450 aromatase, the enzyme catalysing androgens aromatization into estrogens, are both expressed in human adipose tissue...
  30. ncbi Herbicide atrazine activates SF-1 by direct affinity and concomitant co-activators recruitments to induce aromatase expression via promoter II
    WuQiang Fan
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 355:1012-8. 2007
    ..We recently reported that atrazine induces human aromatase gene expression via promoter II (ArPII) in a steroidogenic factor 1 (SF-1)-dependent manner...
  31. pmc The alternative noncoding exons 1 of aromatase (Cyp19) gene modulate gene expression in a posttranscriptional manner
    Hanzhou Wang
    Department of Molecular Medicine, Institute of Biotechnology, 15355 Lambda Drive, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Endocrinology 150:3301-7. 2009
    b>Aromatase (Cyp19) is a key enzyme in estrogen biosynthesis and an important target in endocrine therapy for estrogen receptor (ER)-positive postmenopausal breast cancer...
  32. pmc Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells
    Stefania Catalano
    Department of Pharmaco Biology, University of Calabria, 87030 Arcavacata di Rende Cs, Italy
    J Biol Chem 285:5581-93. 2010
    ..Recently, FXR was identified as a negative modulator of the androgen-estrogen-converting aromatase enzyme in human breast cancer cells...
  33. ncbi Association of genetic polymorphisms in CYP19 and CYP1A1 with the oestrogen receptor-positive breast cancer risk
    Y Miyoshi
    Department of Surgical Oncology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Eur J Cancer 39:2531-7. 2003
    ..Thus, the significance of genetic polymorphisms of genes involved in oestrogen biosynthesis (CYP19) and metabolism (CYP1A1) as a risk factor for ER-positive breast cancers was evaluated...
  34. ncbi Quantitative analysis of aromatase mRNA expression derived from various promoters (I.4, I.3, PII and I.7) and its association with expression of TNF-alpha, IL-6 and COX-2 mRNAs in human breast cancer
    Natsumi Irahara
    Department of Surgical Oncology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Int J Cancer 118:1915-21. 2006
    The purpose of the present study was to study the aromatase mRNA expression as well as promoter usage (I.4, I.3, PII and I...
  35. ncbi Genetic polymorphisms of the CYP19A1 gene and breast cancer survival
    Ji Rong Long
    Department of Medicine, Center for Epidemiologic Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2587, USA
    Cancer Epidemiol Biomarkers Prev 15:2115-22. 2006
    The CYP19A1 protein (aromatase) plays a critical role in estrogen biosynthesis and thus may be related to the progression of breast cancer...
  36. doi A single-nucleotide polymorphism in the aromatase gene is associated with the efficacy of the aromatase inhibitor letrozole in advanced breast carcinoma
    Ramon Colomer
    M D Anderson Cancer Center España, Madrid, Spain
    Clin Cancer Res 14:811-6. 2008
    To evaluate the efficacy of treatment with the aromatase inhibitor letrozole in breast cancer patients segregated with respect to DNA polymorphisms of the aromatase gene CYP19.
  37. doi The CYP19 TTTA repeat polymorphism is related to the prognosis of premenopausal stage I-II and operable stage III breast cancers
    Chiun Sheng Huang
    Department of Surgery, National Taiwan University Hospital, No 7, Chung Shan South Road, Taipei, Taiwan
    Oncologist 13:751-60. 2008
    Given the critical role of the CYP19 gene, encoding aromatase, in estrogen synthesis and the association of the estrogen level with its TTTA repeat polymorphism, the potential influence of this polymorphism on breast cancer survival, and ..
  38. pmc Variation in the CYP19A1 gene and risk of colon and rectal cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, Salt Lake City, UT 84108, USA
    Cancer Causes Control 22:955-63. 2011
    CYP19A1, or aromatase, influences estrogen-metabolizing enzymes and may influence cancer risk...
  39. pmc Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries
    Y Ito
    Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas 75235
    Proc Natl Acad Sci U S A 90:11673-7. 1993
    We identified two mutations in the CYP19 gene responsible for aromatase deficiency in an 18-year-old 46,XX female with ambiguous external genitalia at birth, primary amenorrhea and sexual infantilism, and polycystic ovaries...
  40. ncbi Polymorphisms in steroid hormone pathway genes and mammographic density
    Christopher A Haiman
    Department of Epidemiology, Harvard School of Public Health Boston, MA, USA
    Breast Cancer Res Treat 77:27-36. 2003
    ..to investigate variation in mammographic breast density, by 10 polymorphisms in eight candidate genes (CYP17, CYP19, CYP1A1, CYP1B1, COMT, UGT1A1, AR, and AIB1). Breast density was assessed using a computer-assisted technique...
  41. ncbi Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women
    Shelley S Tworoger
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:94-101. 2004
    ..may influence sex hormone concentrations have been identified, including CYP17 (5'-untranslated region T-->C), CYP19 [intron 4 (TTTA)(n = 7-13) and a 3-bp deletion (-3)], CYP1B1 (Val(432)Leu), and COMT (Val(108/158)Met)...
  42. ncbi Organization of the human aromatase p450 (CYP19) gene
    Serdar E Bulun
    Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
    Semin Reprod Med 22:5-9. 2004
    ..in general, including adipose tissue of the disease-free breast, on the other hand, maintains low levels of aromatase expression primarily via promoter I.4, which lies 73 kb upstream of the common coding region. Promoters I...
  43. ncbi Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria
    Cancer 101:264-9. 2004
    ..In these candidate genes, no critical combination of single-nucleotide polymorphisms (SNPs) for assessing breast carcinoma risk has been reported to date...
  44. ncbi Association of an aromatase TTTA repeat polymorphism with circulating estrogen, bone structure, and biochemistry in older women
    I M Dick
    School of Medicine and Pharmacology, Univ of Western Australia, 4th Floor G Block, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
    Am J Physiol Endocrinol Metab 288:E989-95. 2005
    Osteoporosis is a disease that is strongly genetically determined. Aromatase converts androgens to estradiol in postmenopausal women, therefore polymorphisms of the gene for this enzyme may be associated with bone mass and fracture...
  45. ncbi Aromatase expression in ovarian epithelial cancers
    S Cunat
    Laboratoire de Biologie Cellulaire et Hormonale, Centre Hospitalier Universitaire de Montpellier, Hopital Arnaud de Villeneuve, 34295 Montpellier Cedex 5, France
    J Steroid Biochem Mol Biol 93:15-24. 2005
    Our study focused on aromatase cytochrome P450 (CYP19) expression in ovarian epithelial normal and cancer cells and tissues...
  46. ncbi Aromatase in endometriosis and uterine leiomyomata
    Serdar E Bulun
    Department of Obstetric and Gynecology, Northwestern University, 303 E Superior Street, Suite 4 123, Chicago, IL 60611, USA
    J Steroid Biochem Mol Biol 95:57-62. 2005
    Endometrial tissue from uterine disease-free women does not exhibit aromatase activity. In contrast, aromatase enzyme activity and mRNA levels are readily detectable in endometriosis...
  47. ncbi CYP19 (TTTA)n polymorphism and breast cancer risk in Brazilian women
    Fabiana Siqueira Ribeiro
    Departamento de Bioquimica, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Av 28 de Setembro, 87 Fundos, 4 andar, Rio de Janeiro, RJ 20551 013, Brazil
    Toxicol Lett 164:90-5. 2006
    ..The CYP19 gene encodes the enzyme aromatase, which catalyzes the conversion of androgens into estrogens...
  48. ncbi Quantitative analysis of aromatase, sulfatase and 17beta-HSD(1) mRNA expression in soft tissue metastases of breast cancer
    Natsumi Irahara
    Department of Breast and Endocrine Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Cancer Lett 243:23-31. 2006
    Expression of the estrogen-synthesizing genes aromatase, steroid sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type1 (17beta-HSD(1)) has been shown to be up-regulated in primary breast cancer tissue but their expression status ..
  49. ncbi Expression of aromatase and 17beta-hydroxysteroid dehydrogenase types 1, 7 and 12 in breast cancer. An immunocytochemical study
    D Song
    First Teaching Hospital of Jilin University, Changchun, China
    J Steroid Biochem Mol Biol 101:136-44. 2006
    ..The steroidogenic enzymes involved in E2 formation are aromatase which transforms testosterone into E2 and androstenedione into estrone (E1) and reductive 17beta-hydroxysteroid ..
  50. ncbi EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    J Biol Chem 283:3433-44. 2008
    Cytochrome P450 aromatase (aromatase), a product of the CYP19 gene, catalyzes the synthesis of estrogens from androgens...
  51. pmc Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese women
    Hui Cai
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Pharmacogenet Genomics 18:657-64. 2008
    ..We investigated the associations of genetic polymorphisms in CYP19A1, a critical gene involved in estrogen synthesis, with plasma levels of sex hormones among postmenopausal Chinese women...
  52. pmc Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer
    Neal D Freedman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA
    Carcinogenesis 30:71-7. 2009
    ..These findings should be interpreted cautiously until replicated in other studies...
  53. pmc Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors
    Liewei Wang
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 70:319-28. 2010
    b>Aromatase (CYP19) is a critical enzyme in estrogen biosynthesis and aromatase inhibitors (AI) are employed widely for endocrine therapy in postmenopausal women with breast cancer...
  54. doi Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104 0045, Japan
    Nutr Cancer 62:466-75. 2010
    We tested the hypothesis that polymorphisms in cytochrome P450c17alpha (CYP17), aromatase (CYP19), 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1) and sex hormone-binding globulin (SHBG) genes may modify the association between ..
  55. doi Association of CYP19A1 polymorphisms with risks for atypical adenomatous hyperplasia and bronchioloalveolar carcinoma in the lungs
    Takashi Kohno
    Biology Division, National Cancer Center Research Institute Tokyo 104 0045, Japan
    Carcinogenesis 31:1794-9. 2010
    ..079) in a population of 363 postmenopausal women without cancer. These results indicate that CYP19A1 polymorphisms are involved in the risk for lung AAH and BAC in the lungs by causing differences in estrogen levels...
  56. pmc Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women
    Susan E Olivo-Marston
    Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 31:1778-86. 2010
    ..Understanding the genetic control of estrogen biosynthesis and response in lung cancer could lead to improved prognosis and therapy...
  57. doi Efficient expression of human aromatase (CYP19) in E. coli
    Norio Kagawa
    Office of Global COE, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Methods Mol Biol 705:109-22. 2011
    Human aromatase (CYP19, P450arom) is responsible for the conversion of androgens to estrogens...
  58. pmc Motion and flexibility in human cytochrome p450 aromatase
    Wenhua Jiang
    Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, New York, United States of America
    PLoS ONE 7:e32565. 2012
    The crystal structures of human placental aromatase in complex with the substrate androstenedione and exemestane have revealed an androgen-specific active site and the structural basis for higher order organization...
  59. pmc Associations between aromatase CYP19 rs10046 polymorphism and breast cancer risk: from a case-control to a meta-analysis of 20,098 subjects
    Begoña Pineda
    Institute of Health Research INCLIVA, Valencia, Spain
    PLoS ONE 8:e53902. 2013
    ..Among them, the CYP19 gene encodes for aromatase, the enzyme that catalyzes the conversion of androgens to estrogens...
  60. doi Association of a genetic variant of CYP19A1 with multicentric development of lung adenocarcinomas
    Koei Ikeda
    Department of Thoracic Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Ann Surg Oncol 21:939-45. 2014
    ..In this study, we examined single nucleotide polymorphisms (SNPs) of the cytochrome P450 19A1 gene to determine if they are associated with multiple adenocarcinomas risk.
  61. pmc Resonance Raman spectroscopy of the oxygenated intermediates of human CYP19A1 implicates a compound i intermediate in the final lyase step
    Piotr J Mak
    Department of Chemistry, Marquette University, Milwaukee, Wisconsin 53233, United States
    J Am Chem Soc 136:4825-8. 2014
    CYP19A1, or aromatase, a cytochrome P450 responsible for estrogen biosynthesis in humans, is an important therapeutic target for the treatment of breast cancer...
  62. ncbi Tissue-specific promoters regulate aromatase cytochrome P450 gene expression in human ovary and fetal tissues
    G D Means
    Cecil H and Ida Green Center for Reproductive Biological Sciences, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235 9051
    Mol Endocrinol 5:2005-13. 1991
    The formation of estrogens from C19 steroids is catalyzed by a specific form of cytochrome P450, aromatase cytochrome P450 (P450AROM; the product of the CYP19 gene)...
  63. ncbi Structural and functional characterization of human aromatase P-450 gene
    K Toda
    Department of Medical Chemistry, Kochi Medical School, Japan
    Eur J Biochem 193:559-65. 1990
    The gene encoding aromatase P-450 (CYP XIX) has been isolated from two types of human genomic DNA libraries. It spans at least 70 kb and consists of 10 exons...
  64. ncbi Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis
    G D Means
    Department of Obstetrics and Gynecology, Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas 75235 9051
    J Biol Chem 264:19385-91. 1989
    The structural gene encoding aromatase cytochrome P-450 (P-450AROM) was isolated from human genomic DNA. The gene spans at least 52 kilobases and is composed of 10 exons, the first of which is untranslated...
  65. pmc Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells
    C J Corbin
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235
    Proc Natl Acad Sci U S A 85:8948-52. 1988
    The isolation and cloning of a full-length cDNA insert complementary to mRNA encoding human aromatase system cytochrome P-450 is reported. The insert contains an open reading frame encoding a protein of 503 amino acids...
  66. ncbi Human aromatase: cDNA cloning, Southern blot analysis, and assignment of the gene to chromosome 15
    S A Chen
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, CA 91010
    DNA 7:27-38. 1988
    The amino acid sequence of human placental aromatase was determined in part (about 40%) by microsequencing methods...
  67. ncbi Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man
    E P Smith
    Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45229
    N Engl J Med 331:1056-61. 1994
    ..Estrogen-receptor DNA, extracted from lymphocytes, was evaluated by analysis of single-strand-conformation polymorphisms and by direct sequencing...
  68. ncbi Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens
    A Morishima
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Endocrinol Metab 80:3689-98. 1995
    The aromatase enzyme complex catalyzes the conversion of androgens to estrogens in a wide variety of tissues, including the ovary, testis, placenta, brain, and adipose tissue...
  69. ncbi Effect of testosterone and estradiol in a man with aromatase deficiency
    C Carani
    Department of Internal Medicine, University of Modena, Italy
    N Engl J Med 337:91-5. 1997
  70. ncbi Peptide inhibition of cytokine-stimulated aromatase activity in breast tissue fibroblasts
    D Parish
    Endocrinology and Metabolic Medicine, Imperial College School of Medicine, St Mary s Hospital, W2 1NY, London, UK
    J Steroid Biochem Mol Biol 79:165-72. 2001
    The cytokine interleukin-6 (IL-6) and its soluble receptor (IL-6sR) can act synergistically to stimulate aromatase activity in cultured stromal fibroblasts derived from breast tissues...
  71. ncbi Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes
    Colin D Clyne
    Prince Henry s Institute of Medical Research, 246 Clayton Road, Clayton VIC 3168, Australia
    J Biol Chem 277:20591-7. 2002
    Estrogen biosynthesis from C(19) steroids is catalyzed by aromatase cytochrome P450. Aromatase is expressed in breast adipose tissue through the use of a distal, cytokine-responsive promoter (promoter I.4)...
  72. ncbi Effect of germ-line genetic variation on breast cancer survival in a population-based study
    Ellen L Goode
    Cancer Research United Kingdom Genetic Epidemiology Group, Strangeways Research Laboratories, University of Cambridge, Wort s Causeway, Cambridge CB1 8RN, United Kingdom
    Cancer Res 62:3052-7. 2002
    ..2 (1.8-9.4); P = 0.01]. Total length of a CYP19 IVS4 (ttta)(n) repeat was also associated with survival [HR, 0.9 (0.8-1.0); P = 0...
  73. ncbi The aromatase cytochrome P-450 and its clinical impact
    Udo Meinhardt
    University Children s Hospital, Inselspital, Bern, Switzerland
    Horm Res 57:145-52. 2002
    Cytochrome P-450 aromatase (P450arom), the key enzyme for estrogen biosynthesis, is encoded by a single gene, namely the CYP19 gene, localized on 15q21.2...
  74. ncbi Reproductive system: aromatase and estrogens
    Serge Carreau
    Universite de Caen, Biochimie IRBA UPRES EA 2608 USC INRA, Esplanade de la Paix, 14032 Caen Cedex, France
    Mol Cell Endocrinol 193:137-43. 2002
    The cytochrome P450 aromatase (P450arom) is the terminal enzyme responsible for the formation of estrogens from androgens...
  75. ncbi Expression of messenger ribonucleic acid encoding steroidogenic enzymes in postmenopausal ovaries
    Manubai Nagamani
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Galveston, Texas, USA
    J Soc Gynecol Investig 10:37-40. 2003
    ..cDNA probes encoding human P450 side chain cleavage (P450(SSC)), P450(17alpha), and cytochrome P450 aromatase (P450(arom))...
  76. ncbi The CYP19 gene and associations with androgens and abdominal obesity in premenopausal women
    Fariba Baghaei
    The Cardiovascular Institute, Sahlgrenska University Hospital, Goteborg, Sweden
    Obes Res 11:578-85. 2003
    ..androgens in women are associated with type 2 diabetes and are dependent on the conversion to estrogens by aromatase cytochrome P450...
  77. ncbi A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, 1441 Eastlake Ave, Rm 4441, Los Angeles, CA 90089 9175, USA
    Hum Mol Genet 12:2679-92. 2003
    The CYP19 gene encodes for aromatase (P450arom), a key steroidogenic enzyme that catalyzes the final step of estrogen biosynthesis...
  78. ncbi A polymorphic CYP19 TTTA repeat influences aromatase activity and estrogen levels in elderly men: effects on bone metabolism
    Luigi Gennari
    Department of Internal Medicine, University of Florence, 50139 Florence, Italy
    J Clin Endocrinol Metab 89:2803-10. 2004
    ..plays a dominant role in determining bone mineral density (BMD) in men, and inactivating mutations in the aromatase CYP19 gene have been associated with low bone mass in young males...
  79. ncbi Polymorphisms associated with circulating sex hormone levels in postmenopausal women
    Alison M Dunning
    Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    J Natl Cancer Inst 96:936-45. 2004
    ..We investigated the association between levels of sex hormones and single nucleotide polymorphisms (SNPs) in genes coding for the enzymes that regulate them...
  80. ncbi The CYP19 gene codon 39 Trp/Arg polymorphism increases breast cancer risk in subsets of premenopausal Japanese
    Kaoru Hirose
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden Chikusa ku, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 13:1407-11. 2004
    The production of estrogen from androgen via the estrogen biosynthesis pathway is catalyzed by aromatase P450 (CYP19)...
  81. ncbi CYP19 (aromatase) haplotypes and endometrial cancer risk
    Randi A Paynter
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 116:267-74. 2005
    Endogenous estrogen exposure is an important determinant of endometrial cancer risk. Aromatase, encoded by CYP19, catalyzes the aromatization of androstenedione and testosterone to estrone and estradiol, respectively...
  82. ncbi Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment
    Serdar E Bulun
    Division of Reproductive Biology Research, Department of Obstetric and Gynecology, Northwestern University, Chicago, IL 60611, USA
    Pharmacol Rev 57:359-83. 2005
    A single gene encodes the key enzyme for estrogen biosynthesis termed aromatase, inhibition of which effectively eliminates estrogen production...
  83. ncbi Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study
    Inga Peter
    Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Hypertens 23:2193-200. 2005
    ..To examine the association between variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in men and women...
  84. ncbi Aromatase in the context of breast and endometrial cancer. A review
    V H W M Jongen
    Department of Obstetrics, Diaconessenhuis Meppel, Meppel, The Netherlands
    Minerva Endocrinol 31:47-60. 2006
    ..The local presence of androgens and the local expression and activity of aromatase is considered important for this steroidogenesis...
  85. pmc CYP19 haplotypes increase risk for Alzheimer's disease
    R Huang
    J Med Genet 43:e42. 2006
    Cytochrome P450 aromatase, an enzyme that catalyses the conversion of androgens to oestrogen, is expressed at high levels in the gonads and in the brain...
  86. ncbi Associations among mammographic density, circulating sex hormones, and polymorphisms in sex hormone metabolism genes in postmenopausal women
    Ruth Warren
    Department of Radiology, University of Cambridge, United Kingdom
    Cancer Epidemiol Biomarkers Prev 15:1502-8. 2006
    ..globulin (SHBG), androstenedione, 17-OH-progesterone, estrone, and estrone sulfate] and 15 SNPs in the CYP17, CYP19, EDH17B2, SHBG, COMT, and CYP1B1 genes were studied...
  87. ncbi Polymorphisms in the estrogen synthesis and metabolism pathways and symptoms during the menopausal transition: observations from the Seattle Midlife Women's Health Study
    Nancy F Woods
    Department of Family and Child Nursing, School of Nursing, University of Washington, Seattle, WA 98195 7260, USA
    Menopause 13:902-10. 2006
    ..The purpose of this study was to determine whether polymorphisms in the estrogen synthesis and metabolism pathways are associated with women's vasomotor symptom experiences during the menopausal transition...
  88. pmc A comprehensive examination of CYP19 variation and risk of breast cancer using two haplotype-tagging approaches
    Janet E Olson
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55901, USA
    Breast Cancer Res Treat 102:237-47. 2007
    ..Androgens are converted to estrogens by the aromatase enzyme, which is encoded by the CYP19 gene...
  89. ncbi 5Alpha-reductase type 1 and aromatase in breast carcinoma as regulators of in situ androgen production
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Int J Cancer 120:285-91. 2007
    ..was positively associated with 5alpha-reductase type 1 (5alphaRed1), and negatively correlated with aromatase. We then examined clinical significance of AR and 5alphaRed1 status in 115 breast carcinoma tissues by ..
  90. ncbi Identification of an aromatase haplotype that is associated with gene expression and postmenopausal osteoporosis
    Jose A Riancho
    Department of Internal Medicine, Hospital U M Valdecilla, University of Cantabria, 39008 Santander, Spain
    J Clin Endocrinol Metab 92:660-5. 2007
    Osteoporosis has a significant genetic component. The aromatase-dependent conversion of androgenic precursors is the main source of estrogens in postmenopausal women.
  91. ncbi A multigenic study on breast cancer risk associated with genetic polymorphisms of ER Alpha, COMT and CYP19 gene in BRCA1/BRCA2 negative Shanghai women with early onset breast cancer or affected relatives
    Zhen Hu
    Breast Cancer Institute, Cancer Hospital, Department of Oncology, Shanghai Medical College, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
    J Cancer Res Clin Oncol 133:969-78. 2007
    ..The genotypes of estrogen receptor alpha (ERalpha), aromatase (CYP19), and catechol-O-methyltransferase (COMT) genes were analyzed by direct DNA-sequencing...
  92. ncbi Breast cancer: a candidate gene approach across the estrogen metabolic pathway
    Christina Justenhoven
    Molecular Mechanisms of Origin and Treatment of Breast Cancer, Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, Stuttgart, Germany
    Breast Cancer Res Treat 108:137-49. 2008
    ..The tested polymorphisms of the estrogen metabolic pathway may not play a direct role in breast cancer risk. Therefore, future association studies should be extended to other polymorphisms and other regulatory pathways...
  93. ncbi Single nucleotide polymorphisms of the aromatase gene (CYP19A1), HER2/neu status, and prognosis in breast cancer patients
    Peter Andreas Fasching
    University Breast Center for Franconia, Department of Gynecology and Obstetrics, Erlangen University Hospital, Erlangen, Germany
    Breast Cancer Res Treat 112:89-98. 2008
    ..b>Aromatase is involved in the production of estrogens, and altered expression of it might be associated with the prognosis...
  94. pmc Haplotype analyses of CYP19A1 gene variants and breast cancer risk: results from the Shanghai Breast Cancer Study
    Qiuyin Cai
    Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, B 2104 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232 2400, USA
    Cancer Epidemiol Biomarkers Prev 17:27-32. 2008
    Estrogens play a central role in the etiology of breast cancer. The CYP19A1 gene encodes aromatase, a key enzyme in the biosynthesis of estrogens...
  95. doi Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women
    Lina Zhang
    Departments of Breast Oncology Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, PR China
    Breast Cancer Res Treat 114:327-38. 2009
    ..regulatory regions of ER-alpha (rs3798577) and other two estrogen-metabolizing enzyme genes CYP17 (rs743572) and CYP19 (rs10046) among 300 breast cancer cases and 390 controls in a Chinese population...
  96. ncbi Multilocus analyses reveal involvement of the ESR1, ESR2, and FSHR genes in migraine
    Agustin Oterino
    University Hospital Marqués de Valdecilla Neurology, Santander, Spain
    Headache 48:1438-50. 2008
    ..Research in this field has been controversial, especially in regard to ESR1 gene findings. None of the reports have yet to approach the problem from a multigenic point of view...
  97. pmc Two estrogen-related variants in CYP19A1 and endometrial cancer risk: a pooled analysis in the Epidemiology of Endometrial Cancer Consortium
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Cancer Epidemiol Biomarkers Prev 18:242-7. 2009
    ..Our study provides evidence that CYP19A1 genetic variation influences susceptibility to endometrial cancer, particularly among older and obese women...
  98. pmc Structural basis for androgen specificity and oestrogen synthesis in human aromatase
    Debashis Ghosh
    Structural Biology, Hauptman Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, New York 14203, USA
    Nature 457:219-23. 2009
    b>Aromatase cytochrome P450 is the only enzyme in vertebrates known to catalyse the biosynthesis of all oestrogens from androgens. Aromatase inhibitors therefore constitute a frontline therapy for oestrogen-dependent breast cancer...
  99. doi Alternative 5'-untranslated first exons of the mouse Cyp19A1 (aromatase) gene
    Jenny D Y Chow
    Prince Henry s Institute, Clayton, VIC 3168, Australia
    J Steroid Biochem Mol Biol 115:115-25. 2009
    The human aromatase gene (CYP19A1) has eleven tissue-specific untranslated first exons, while only three have been described in the mouse Cyp19A1 namely brain-, ovary- and testis-specific exons 1...
  100. doi Rapid estradiol/ERalpha signaling enhances aromatase enzymatic activity in breast cancer cells
    Stefania Catalano
    Department of Pharmaco Biology, University of Calabria, Arcavacata di Rende CS 87030, Italy
    Mol Endocrinol 23:1634-45. 2009
    In situ estrogen production by aromatase conversion from androgens plays an important role in breast tumor promotion...
  101. pmc CYP19A1 genetic variation in relation to prostate cancer risk and circulating sex hormone concentrations in men from the Breast and Prostate Cancer Cohort Consortium
    Ruth C Travis
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Richard Doll Building, Oxford, United Kingdom
    Cancer Epidemiol Biomarkers Prev 18:2734-44. 2009
    ..These results suggest that although germline variation in CYP19A1 characterized by the htSNPs produces measurable differences in sex hormone concentrations in men, they do not substantially influence risk of prostate cancer...

Research Grants71

  1. MicroRNA Signature of Tamoxifen Resistance in Breast Cancer
    Sarmila Majumder; Fiscal Year: 2010
    ..Recently, alternative endocrine therapies, such as aromatase inhibitors (AI), are found to be more effective in estrogen receptor positive, post-menopausal women with breast ..
  2. Christopher Benz; Fiscal Year: 2014
    ..ER (designated ER+), signifying that they MAY respond favorably to endocrine therapy with tamoxifen or aromatase inhibitors...
  3. Erik Knudsen; Fiscal Year: 2014
    ..g. tamoxifen) or through ER ligand depletion strategies (e.g. aromatase inhibitors)...
  4. Diana M Cittelly; Fiscal Year: 2015
    ..Steroid hormones produced by gonads or adrenals cross the blood brain barrier, and are also produced locally by aromatase expressed in neurons and astrocytes...
  5. VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2014
    ..e., tumors that are resistant to mainstay breast cancer therapies such as tamoxifen and aromatase inhibitors) breast cancer xenograft models...
  6. Development of Breast Cancer Risk Model Based on Estrogen Metabolomics
    Richard J Santen; Fiscal Year: 2013
    ..We anticipate reducing the number of women needed to be treated to prevent one breast cancer from 50 to 13 with tamoxifen and to 5.with aromatase inhibitors.
  7. Targeting endocrine resistant breast cancer with anacardic acid
    David Schultz; Fiscal Year: 2013
    ..g., tamoxifen (TAM)) and aromatase inhibitors (AI, e.g. letrozole) against which tumor cells become resistant...
  8. Theranostic Nanomedicine for Breast Cancer Prevention and Image-Guided Therapy
    Prakash R Rai; Fiscal Year: 2011
    ..and limiting toxicity of chemo-preventive agents which include selective estrogen receptor antagonists, aromatase inhibitors, retinoids, COX-2 inhibitors and metformin...
  9. Prakash R Rai; Fiscal Year: 2014
    ..and limiting toxicity of chemo-preventive agents which include selective estrogen receptor antagonists, aromatase inhibitors, retinoids, COX-2 inhibitors and metformin...
  10. Mechanisms of Breast Tumor Cell Growth, Motility, and Antiestrogen Response
    Amy H Bouton; Fiscal Year: 2013
    ..with hormonal therapies designed to inhibit receptor function (antiestrogens) or block production of estrogens (aromatase inhibitors)...
  11. Syreeta L Tilghman; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Although aromatase inhibitors, such as letrozole, are the standard endocrine therapy of choice for post-menopausal women with early-stage metastatic estrogen-dependent breast cancer, the major ..
  12. PATRICIA ANN THOMPSON; Fiscal Year: 2016
    ..b>Aromatase inhibitors (AI) are recommended as first-line adjuvant therapy for hormone responsive tumors in postmenopausal ..
  13. Endocrine resistance in breast cancer
    ROBERT R CLARKE; Fiscal Year: 2013
    ..of how cellular signaling to regulate cell fate is differentially affected by estrogens, antiestrogens, and aromatase inhibitors in sensitive and resistant breast cancers...
  14. REINA C VILLAREAL; Fiscal Year: 2014
    ..Estrogen in males is mainly derived from the conversion of testosterone to estradiol by the enzyme aromatase. Polymorphisms of the aromatase gene (CYP19A1) have been reported to result in variable enzyme activity ..
  15. RCT of exercise on aromatase inhibitor side effects in breast cancer survivors
    Melinda L Irwin; Fiscal Year: 2012
    ..the standard adjuvant hormonal therapy for women with early- stage, hormone receptor-positive breast cancer, the aromatase inhibitors (AI's) have rapidly supplanted tamoxifen as the hormonal therapy of choice...
  16. Song Yao; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Aromatase inhibitors (AIs) have been rapidly replacing tamoxifen (TAM) as first-line adjuvant hormonal therapy for postmenopausal women diagnosed with hormone receptor (HR)-positive, early-stage ..
  17. Fractures, Heart Disease, and Stroke on Aromatase Inhibitors
    Nancy L Keating; Fiscal Year: 2010
    ..Recently, randomized controlled trials identifying substantial benefits of aromatase inhibitors for early- stage cancers have led to national recommendations that every postmenopausal woman with an ..
  18. Epigenetic Regulation of Breast Cancer Progression by the Proto-oncogene PELP1
    MONICA MANN; Fiscal Year: 2013
    ..Endocrine therapies using tamoxifen and aromatase inhibitors substantially improve disease- free survival, however, initial or acquired resistance frequently ..
  19. Robert A Gatenby; Fiscal Year: 2015
    ..to combine three chemotherapeutic strategies currently used in the clinic: (a) hormonal therapy (tamoxifen and aromatase inhibitors), (b) targeted therapy (herceptin), and (c) standard chemotherapy (doxorubicin and taxol)...
  20. Suzanne Aw Fuqua; Fiscal Year: 2016
    ..tumors re- gress but then regrow, suggesting that the mutation also confers resistance to therapies such as aromatase inhibitors (AIs)...
  21. A Neoadjuvant Trial of Anastrazole and A Novel SRC Inhibitor, AZD0530, for LABC
    JOYCE MARIE contact SLINGERLAND; Fiscal Year: 2010
    ..receptor 1 (ER) is expressed in 70% of new breast cancers but de novo and acquired resistance to tamoxifen or aromatase inhibitors (AI) limit their efficacy...
  22. The role of the mTOR signaling pathway in ER-positive breast cancer
    MARINA KAUFMAN HOLZ; Fiscal Year: 2013
    ..ER-positive breast cancers can be targeted therapeutically by antiestrogens (such as tamoxifen) or aromatase inhibitors (AIs)...
  23. Cognitive Functioning After Breast Cancer Treatment
    Patricia A Ganz; Fiscal Year: 2010
    ..surgery, radiation, chemotherapy) and who are about to initiate adjuvant endocrine therapy (with tamoxifen or aromatase inhibitors)...
  24. Philip Lazarus; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Aromatase inhibitors (AIs) are widely used as adjuvant treatment for estrogen-receptor positive breast cancer in post-menopausal women...
  25. Androgens and musculoskeletal symptoms among breast cancer patients on aromatase
    Lisa Gallicchio; Fiscal Year: 2010
    b>Aromatase inhibitors, which suppress the production of estrogens by binding to the aromatase enzyme, have become the hormonal adjuvant treatment of choice for postmenopausal breast cancer...
  26. Treatment of vulvo-vaginal atrophy with a novel formulation of Tamoxifen
    Fred Mermelstein; Fiscal Year: 2012
    ..The patient population includes 600,000 menopausal aged women in the United States currently using aromatase inhibitors ("AI therapy") to prevent breast cancer recurrence...
  27. James Michael Rae; Fiscal Year: 2015
    ..therapies including the Selective Estrogen Receptor Modulator (SERM) tamoxifen, and the 3rd generation aromatase inhibitors (AI) including anastrozole, letrozole, and exemestane have clearly played a substantial role in ..
  28. 18F-Fluoroestradiol PET/CT guided fulvestrant therapy for patients with recurrent
    Stephen Chia; Fiscal Year: 2010
    ..is not curable however, and virtually all patients will eventually develop resistance to both tamoxifen and the aromatase inhibitors...
  29. TRANSLATIONAL RESEARCH IN BREAST CANCER
    C Kent Osborne; Fiscal Year: 2012
    ..of the androgen receptor may be an important cause of resistance to endocrine therapy with either tamoxifen or aromatase inhibitors...
  30. AROMATASE AND BREAST CANCER
    Angela M Brodie; Fiscal Year: 2013
    ..The aromatase inhibitors we pioneered in the early phases of this grant are now proving to be of value in the clinic...
  31. Measures of Endocrine Sensitivity in Early Breast Cancer
    Hannah M Linden; Fiscal Year: 2010
    ..Recently aromatase inhibitors (AIs) have been shown to provide incremental benefit over tamoxifen...
  32. Predictors of Ovarian Function in Women Treated With Aromatase Inhibitors
    NORAH LYNN HENRY; Fiscal Year: 2012
    ..the design, execution, and interpretation of studies related to predictors of ovarian function during adjuvant aromatase inhibitor(AI) therapy for breast cancer, and (3) substantial collaboration with senior colleagues in the ..
  33. Thasarat Vajaranant; Fiscal Year: 2016
    ..This training and line of research will provide a foundation for future studies investigating the effects of aromatase inhibitors, selective estrogen receptor modulators and other anti- estrogen treatments on the optic nerve...
  34. Steven M Kawut; Fiscal Year: 2016
    ..variation in estrogen receptor βwas associated with the occurrence of HPS , and 3) genetic variation in aromatase was associated with both higher plasma estradiol (E2) levels and a higher risk of PPHTN...
  35. KRISTEN LEANNE ZULOAGA; Fiscal Year: 2015
    ..women, the major source of estrogen becomes local (extra-gonadal) synthesis of estradiol by the enzyme aromatase. Aromatase is expressed in numerous cell types, including vascular endothelial cells (EC)...
  36. The new biology of estrogen action in aromatase resistance breast cancer cells
    JOAN SUEDEE LEWIS-WAMBI; Fiscal Year: 2011
    ..PA) and I am submitting a K01 application to study the new biology of estrogen and fulvestrant action in aromatase inhibitor resistant breast cancer cells...
  37. Linda Susan Taichman; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Aromatase inhibitors (AIs) are routinely prescribed as adjuvant hormonal therapy for postmenopausal women with hormone receptor positive breast cancer...
  38. Structure and Function of Integral Membrane Enzyme Human Aromatase
    Debashis Ghosh; Fiscal Year: 2012
    Human cytochrome P450 aromatase (P450arom), an integral membrane hemeprotein of the endoplasmic reticulum, catalyzes the synthesis of estrogens from androgens in the presence of P450-reductase...
  39. Flaxseed vs. aromatase inhibitors: breast tumor characteristics and prognosis
    Susan McCann; Fiscal Year: 2009
    ..Used in postmenopausal women, aromatase inhibitors (AI) block the peripheral conversion of androgens to estrogen, effectively lowering the estradiol ..
  40. Regulation of miRNA in breast cancer
    Carolyn M Klinge; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Aromatase inhibitor therapy is not useful for all ER1 positive breast cancer patients and the selective estrogen receptor ..
  41. Dawn Hershman; Fiscal Year: 2015
    Third generation aromatase inhibitors have been shown to be superior to tamoxifen in improving disease free survival, decreasing distant and local recurrence rates and decreasing incidence of contra-lateral breast cancer in women with ..
  42. Liliana E Pezzin; Fiscal Year: 2015
    ..of breast conserving surgery with radiotherapy, the choice and use of alternative adjuvant endocrine therapy (aromatase inhibitors vs. tamoxifen) and possibly persistence with endocrine therapy once initiated...
  43. A Novel Target for the Treatment of Endometriosis
    Paul D Crowe; Fiscal Year: 2011
    ..Endometriotic lesions synthesize estrogen endogenously and this may be pathologically significant. Reports that aromatase inhibitors, which block the final step of estrogen synthesis, are effective in rare cases of post-menopausal ..
  44. Thomas B Hildebrandt; Fiscal Year: 2014
    ..By studying AAS intoxication in relation to aromatase availability, we will be able to understand functional relationships between AAS metabolism and the core ..
  45. ANDREW JESS DANNENBERG; Fiscal Year: 2015
    ..from adipose tissue, since adipose tissue is the primary site of action of the estrogen-synthesizing enzyme aromatase post climacteric...
  46. Personalized therapeutics for inhibiting breast cancer metastasis
    DEBRA AUGUSTE; Fiscal Year: 2012
    ..and human epidermal growth receptor-2 (HER2) on their surface are treated with hormone (anti-estrogen or aromatase inhibitors) or targeted (Herceptin) therapies, respectively...
  47. Marcia I Dawson; Fiscal Year: 2014
    ..In the postmenopausal cancerous breast, expression of the enzyme synthesizing estrogen (aromatase) becomes elevated, as do estrogen and the estrogen nuclear receptor (ER)...
  48. AROMATASE INHIBITORS: SKELETAL EFFECTS AND THE ROLE OF CYP19 GENE POLYMORPHISMS
    Reina Villareal; Fiscal Year: 2007
    ..of estrogen receptor positive (ER+) breast cancer has recently been challenged by a newer class drugs, the aromatase inhibitors, which are found to have superior efficacy over tamoxifen with better side-effect profile...
  49. Vitamin D3 Effects on Musculoskeletal Symptoms with Use of Aromatase Inhibitors
    Alice C Shapiro; Fiscal Year: 2012
    ..will determine the efficacy and safety of vitamin D3 supplements for reducing side effects of treatment with aromatase inhibitors in women with breast cancer...
  50. Jun J Mao; Fiscal Year: 2015
    DESCRIPTION (provided by Investigator): This application entitled, "Estrogen deprivation and Aromatase Inhibitor associated Arthralgia," seeks to apply pharmacogenetic epidemiology, appropriate biomarkers, and validated patient-reported ..
  51. The Mechanism of BRCA1 in Tumor Suppression
    Yanfen Hu; Fiscal Year: 2010
    ..preliminary data lead us to the hypothesis that BRCA1 may negatively regulate the tissue-specific expression of aromatase, a rate-limiting enzyme in estrogen biosynthesis and a key player in breast cancer development...
  52. [11C]vorozole as a PET tracer for in vivo studies of human aromatase
    Anat Biegon; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Aromatase, the cyp19A gene product, is the enzyme responsible for estrogen synthesis. To date, there are no quantitative studies of the distribution and regulation of aromatase in living humans...
  53. Obesity and Endocrine Therapy Resistance in Postmenopausal Mammary Tumorigenesis
    REBECCA E DE ANGEL; Fiscal Year: 2010
    ..b>Aromatase inhibitors (Als) are a promising class of drug for postmenopausal breast cancer treatment that decreases ..
  54. NOVEL AGENT TO RESTORE SENSITIVITY TO ANTI-ESTROGEN THERAPY
    PH D SERRERO; Fiscal Year: 2012
    b>Aromatase Inhibitors (AI) are the preferred hormonal treatment for estrogen receptor positive Breast Cancer (BC) in postmenopausal women and are used to treat approximately 140,000 patients annually in the US...
  55. Ellis R Levin; Fiscal Year: 2014
    ..Whether these mechanisms underlie aromatase inhibitor resistance will also be determined...
  56. Eric Oldfield; Fiscal Year: 2015
    ..the bisphosphonate drug zoledronate has unexpected positive effects as an adjuvant (in combination therapy with aromatase inhibitors) in breast cancer, reducing the re-occurrence of disease (at any site) by 36%, in addition to ..
  57. Alex Joel Polotsky; Fiscal Year: 2015
    ..Use of aromatase inhibitors in men leads to improvement of compromised sperm parameters and reproductive hormones but pregnancy ..
  58. HUIBRIE CHRISTELLE PIETERS; Fiscal Year: 2014
    ..What contributes to discontinuation is poorly understood. Aromatase inhibitors (AIs) are associated with adverse side effects such as an arthralgia syndrome, hot flashes, loss of ..
  59. Breast Cancer Survivors: Physical Activity, Inflammation, Fatigue, and Distress
    Janice K Kiecolt-Glaser; Fiscal Year: 2012
    ..ages 40 and older;the women will have completed cancer treatment within the past year (except for tarnoxifen/aromatase inhibitors), and will be at least two months post surgery or adjuvant therapy or radiation, whichever occurred ..
  60. Novel Direct Approaches Toward Bioactive Heterocycles
    Vladimir Gevorgyan; Fiscal Year: 2013
    ..potential topoisomerase I inhibitors, and tetra- and pentacyclic heterocyclic skeletons, potential QR2 and aromatase inhibitors...
  61. Aromatase Inhibitor in Males with Adrenal Hyperplasia
    Kyriakie Sarafoglou; Fiscal Year: 2006
    ..objective is to treat males who have congenital adrenal hyperplasia (CAH) and decreased spermatogenesis with an aromatase inhibitor in order to investigate its effects on hormonal parameters and spermatogenesis...
  62. MECHANISMS OF INFERTILITY IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2002
    ..Our preliminary results are indicative that the aberrant expression of aromatase and cyclo-oxygenase (COX)-2 and the deficiency of 17beta-hydroxysteroid dehydrogenase type 2 (17beta-HSD-2) in ..
  63. Medications Development for the Pregnant Opiate Addict
    Mahmoud S Ahmed; Fiscal Year: 2010
    ..The activity of aromatase and P-gp are affected by placental genotype and gestational age...
  64. Int5/Aromatase Effect of Breast Estrogen in Neoplasia
    RAJESHWAR TEKMAL; Fiscal Year: 2005
    A number of studies have shown that the levels of aromatase are higher in breast tumors compared to normal tissue, indicating that the in situ aromatase/breast estrogen may play a role in breast cancer...
  65. Treatment effects on hormones in the breast
    Robert Chatterton; Fiscal Year: 2005
    ..The effects of tamoxifen and aromatase inhibitors on estrogen-induced proteins cathepsin D and trefoil family factor-1 (TFF1) will be determined in ..
  66. Female Hormones and Vision
    Alvin Eisner; Fiscal Year: 2006
    ..The clinical emphasis will be on 2 types of medications - selective estrogen receptor modulators (SERMS) and aromatase inhibitors...
  67. BIOCHEMICAL PROBES OF THE ACTIVE SITE OF AROMATASE
    ROBERT BRUEGGEMEIER; Fiscal Year: 1993
    ..in this competing renewal application will continue and extend investigations on the utilization of selected aromatase inhibitors as biochemical tools in studying the active site of aromatase. Investigations by the P.I...
  68. Association of breast cancer and its therapies with fracture
    Joan Neuner; Fiscal Year: 2009
    ..Finally, advances in adjuvant hormonal therapy with the introduction of aromatase inhibitors (AIs) suggest that osteoporosis will become a greater problem in the future...
  69. A Novel Long-Lived 41Ca Marker To Assess Bone Turnover For Breast Cancer Patients
    Susanta Hui; Fiscal Year: 2009
    ..b>Aromatase inhibitor (AI) is very succesful as an adjuvant therapy in estrogen positive postmenopausal women to prevent ..
  70. STRUCTURE-FUNCTION OF STEROIDOGENIC CYTOCHROMES P-450
    John Shively; Fiscal Year: 1990
    ..One focus of our studies will be aromatase, the enzyme responsible for the conversion of androstenedione to estrone and testosterone to estradiol...