ARL8

Summary

Gene Symbol: ARL8
Description: ADP ribosylation factor like GTPase 5B
Alias: ARL8, ADP-ribosylation factor-like protein 5B, ADP-ribosylation factor-like 5B, ADP-ribosylation factor-like 8, ADP-ribosylation factor-like protein 8, ADP-ribosylation-like factor 8
Species: human

Top Publications

  1. doi ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin and modulates intracellular vesicular transport
    Shu mei Wei
    Department of Pathology, Second Affiliated Hospital of Zhejiang University, School of Medicine, Jiefang Road 88, Hangzhou, Zhejiang Province 310009, China
    Biochem Biophys Res Commun 384:352-6. 2009
  2. doi Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b and AP4 dependent pathway
    Wei Hong Toh
    The Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010
    Traffic . 2016
  3. pmc BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks
    Carlos M Guardia
    Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
    Cell Rep 17:1950-1961. 2016
  4. doi Replication of Tobamovirus RNA
    Kazuhiro Ishibashi
    Plant and Microbial Research Unit, Division of Plant and Microbial Sciences, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization NARO, Tsukuba 305 8602, Japan Email
    Annu Rev Phytopathol 54:55-78. 2016
  5. pmc Arf-like GTPase Arl8: Moving from the periphery to the center of lysosomal biology
    Divya Khatter
    Department of Biological Sciences Indian Institute of Science Education and Research Mohali IISERM Mohali, India
    Cell Logist 5:e1086501. 2015
  6. doi Human Cytotoxic T Lymphocytes Form Dysfunctional Immune Synapses with B Cells Characterized by Non-Polarized Lytic Granule Release
    Anna Kabanova
    Department of Life Sciences, University of Siena, Via Aldo Moro 2, Siena 53100, Italy Electronic address
    Cell Rep 15:9-18. 2016
  7. pmc BORC, a multisubunit complex that regulates lysosome positioning
    Jing Pu
    Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 33:176-88. 2015
  8. pmc The small G protein Arl5 contributes to endosome-to-Golgi traffic by aiding the recruitment of the GARP complex to the Golgi
    Cláudia Rosa-Ferreira
    MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
    Biol Open 4:474-81. 2015
  9. pmc Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP
    Morié Ishida
    Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba ku, Sendai, Miyagi 980 8578, Japan
    Sci Rep 5:8238. 2015
  10. pmc Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B
    Yuichi Kitai
    From the Laboratory of Molecular Immunobiology, Graduate School of Biological Sciences, Nara Institute of Science and Technology NAIST, 8916 5 Takayama cho, Ikoma, Nara 630 0192, Japan, the Laboratory of Host Defense, Immunology Frontier Research Center IFReC and Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan, and
    J Biol Chem 290:1269-80. 2015

Research Grants

  1. Kang Shen; Fiscal Year: 2014
  2. Michael B Brenner; Fiscal Year: 2014
  3. ARF BINDING IN THE ACTION OF CHOLERA AND E COLI TOXINS
    Richard Kahn; Fiscal Year: 2002
  4. ARL2: Regulator of Cytoskeleton and Mitochondria
    Richard Kahn; Fiscal Year: 2007

Scientific Experts

  • Anna Kabanova
  • Richard Kahn
  • Hideyasu Okamura
  • Kazuhiro Ishibashi
  • Kang Shen
  • Michael B Brenner
  • Cláudia Rosa-Ferreira
  • Masayuki Ishikawa
  • Masaki Nishikiori
  • Jing Pu
  • Fiona J Houghton
  • Ayaka Sasaki
  • Isei Nakae
  • Wei Hong Toh
  • Carlos M Guardia
  • Rui Jia
  • Juan S Bonifacino
  • Morié Ishida
  • Yuichi Kitai
  • Divya Khatter
  • Paul A Gleeson
  • Dilafruz Juraeva
  • Sean Munro
  • Amra Mrakovic
  • Masamitsu Fukuyama
  • Shohei Mitani
  • Kenji Kontani
  • Toshiaki Katada
  • Keiko Gengyo-Ando
  • Etsuko Katoh
  • Mi Ryung Han
  • Shu mei Wei
  • Thorsten Bangsow
  • Khalisah L Zulkefli
  • Eiman Sebald
  • Jing Zhi A Tan
  • Masuko Katoh
  • Ginny G Farías
  • Takumi Kawasaki
  • Shizuo Akira
  • Taro Kawai
  • Chantal Christis
  • Osamu Takeuchi
  • Mahak Sharma
  • Michal Jarnik
  • Isabel L Torres
  • Peter Backlund
  • Norihiko Ohbayashi
  • Mitsunori Fukuda
  • Takuya Sueyoshi
  • Christina Schindler
  • Motoya Murase
  • Aastha Sindhwani
  • Daisuke Ori
  • Anders Børglum
  • Dan Rujescu
  • Igor Nenadic
  • Josef Frank
  • Markus Leber
  • Rainald Mossner
  • Stephanie H Witt
  • Benedikt Brors
  • Sebastiano Pasqualato
  • Stephan Ripke
  • Franziska Degenhardt
  • Sandra Meier
  • Britta Haenisch
  • Christoph Lange
  • Jens Treutlein
  • Marc Zapatka
  • Markus M Nothen
  • Marcella Rietschel
  • Roel Ophoff
  • Ina Giegling
  • Manuel Mattheisen
  • Heinrich Sauer
  • Thomas W Mühleisen
  • Jana Strohmaier
  • Sven Cichon
  • Wolfgang Maier
  • Thomas G Schulze
  • Keisuke Hashimoto
  • Kota Saito
  • Fumiko Abe
  • Maya Nagasawa
  • John H Brumell
  • Tsuyoshi Inoue
  • Timothy Gemetzis
  • Shigeru Sugiyama
  • Jason G Kay

Detail Information

Publications26

  1. doi ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin and modulates intracellular vesicular transport
    Shu mei Wei
    Department of Pathology, Second Affiliated Hospital of Zhejiang University, School of Medicine, Jiefang Road 88, Hangzhou, Zhejiang Province 310009, China
    Biochem Biophys Res Commun 384:352-6. 2009
    ..This is the second ARL member found interacting with tubulin after ARL8. In addition, ARL7Q72L, a GTP-binding form, promoted the transferrin transport from early endosome to recycling ..
  2. doi Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b and AP4 dependent pathway
    Wei Hong Toh
    The Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010
    Traffic . 2016
    ..These findings demonstrate that APP is diverted from BACE1 at the TGN for direct transport to early endosomes and that the TGN represents a site for APP processing with the subsequent secretion of Aβ...
  3. pmc BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks
    Carlos M Guardia
    Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
    Cell Rep 17:1950-1961. 2016
    ..We recently described a multi-subunit complex named BORC that recruits the small GTPase Arl8 to lysosomes to promote their kinesin-dependent movement toward the cell periphery...
  4. doi Replication of Tobamovirus RNA
    Kazuhiro Ishibashi
    Plant and Microbial Research Unit, Division of Plant and Microbial Sciences, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization NARO, Tsukuba 305 8602, Japan Email
    Annu Rev Phytopathol 54:55-78. 2016
    ..of the genomic RNA by replication proteins onto membranes and formation of a complex with host proteins TOM1 and ARL8; (d) synthesis of complementary (negative-strand) RNA in the complex; and (e) synthesis of progeny genomic RNA...
  5. pmc Arf-like GTPase Arl8: Moving from the periphery to the center of lysosomal biology
    Divya Khatter
    Department of Biological Sciences Indian Institute of Science Education and Research Mohali IISERM Mohali, India
    Cell Logist 5:e1086501. 2015
    ..The small GTPase Arl8, a member of Arf-like (Arl) family of proteins, has recently emerged as a crucial regulator of lysosome positioning ..
  6. doi Human Cytotoxic T Lymphocytes Form Dysfunctional Immune Synapses with B Cells Characterized by Non-Polarized Lytic Granule Release
    Anna Kabanova
    Department of Life Sciences, University of Siena, Via Aldo Moro 2, Siena 53100, Italy Electronic address
    Cell Rep 15:9-18. 2016
    ..signaling and non-polarized release of the lytic granules transported by ADP-ribosylation factor-like protein 8 (Arl8)...
  7. pmc BORC, a multisubunit complex that regulates lysosome positioning
    Jing Pu
    Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 33:176-88. 2015
    ..BORC associates peripherally with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a chain of interactions that promotes the kinesin-dependent movement of lysosomes toward the plus ..
  8. pmc The small G protein Arl5 contributes to endosome-to-Golgi traffic by aiding the recruitment of the GARP complex to the Golgi
    Cláudia Rosa-Ferreira
    MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
    Biol Open 4:474-81. 2015
    ..Thus it appears that Arl5 is one of the factors that directs the recruitment of the GARP complex to the trans-Golgi, and this function is conserved in both flies and humans. ..
  9. pmc Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP
    Morié Ishida
    Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba ku, Sendai, Miyagi 980 8578, Japan
    Sci Rep 5:8238. 2015
    ..Interestingly, Arl8, Arf-like small GTPase that also interacts with SKIP, is specifically localized at lysosomes and regulates their ..
  10. pmc Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B
    Yuichi Kitai
    From the Laboratory of Molecular Immunobiology, Graduate School of Biological Sciences, Nara Institute of Science and Technology NAIST, 8916 5 Takayama cho, Ikoma, Nara 630 0192, Japan, the Laboratory of Host Defense, Immunology Frontier Research Center IFReC and Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan, and
    J Biol Chem 290:1269-80. 2015
    ..Our results, therefore, suggest that Arl5B is a negative regulator for MDA5. ..
  11. pmc Integrated pathway-based approach identifies association between genomic regions at CTCF and CACNB2 and schizophrenia
    Dilafruz Juraeva
    Division of Theoretical Bioinformatics, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS Genet 10:e1004345. 2014
    ....
  12. doi Rab7 and Arl8 GTPases are necessary for lysosome tubulation in macrophages
    Amra Mrakovic
    Molecular Science Program and the Department of Chemistry and Biology, Ryerson University, Toronto, ON, M5B 2K3, Canada
    Traffic 13:1667-79. 2012
    ..Therefore, we identify the first molecular regulators of lysosome tubulation and we show that TLs represent a more dynamic lysosome population...
  13. pmc The resistance protein Tm-1 inhibits formation of a Tomato mosaic virus replication protein-host membrane protein complex
    Kazuhiro Ishibashi
    Division of Plant Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    J Virol 87:7933-9. 2013
    ..as a translation template is not protected from nuclease digestion; and host membrane proteins TOM1, TOM2A, and ARL8 are not copurified with the membrane-bound 130K replication protein...
  14. pmc Arl8/ARL-8 functions in apoptotic cell removal by mediating phagolysosome formation in Caenorhabditis elegans
    Ayaka Sasaki
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Biol Cell 24:1584-92. 2013
    ..Here we show that the Caenorhabditis elegans Arf-like small GTPase Arl8 (ARL-8) is involved in phagolysosome formation and is required for the efficient removal of apoptotic cells...
  15. pmc Crystal structure of the superfamily 1 helicase from Tomato mosaic virus
    Masaki Nishikiori
    Division of Plant Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    J Virol 86:7565-76. 2012
    ..fragment and performed split-ubiquitin-based interaction assays in Saccharomyces cerevisiae with TOM1 and ARL8, host proteins that are essential for tomato mosaic virus RNA replication...
  16. doi Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport
    Fiona J Houghton
    Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010, Australia
    Exp Cell Res 318:464-77. 2012
    ..Collectively these results suggest that Arl5b is a TGN-localised small G protein that plays a key role in regulating transport along the endosome-TGN pathway...
  17. pmc Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication
    Sebastiano Pasqualato
    Laboratoire d Enzymologie et Biochimie Structurales, UPR 9063 CNRS, 1 Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    EMBO Rep 3:1035-41. 2002
    ..We review available genomic sequences and functional data from this perspective, and identify a novel subfamily that we call Arl8.
  18. pmc A host small GTP-binding protein ARL8 plays crucial roles in tobamovirus RNA replication
    Masaki Nishikiori
    Division of Plant Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    PLoS Pathog 7:e1002409. 2011
    ..Here, we show that a small GTP-binding protein ARL8, along with TOM1, is co-purified with a FLAG epitope-tagged ToMV 180K replication protein from solubilized ..
  19. pmc Arl8 and SKIP act together to link lysosomes to kinesin-1
    Cláudia Rosa-Ferreira
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Dev Cell 21:1171-8. 2011
    ..move bidirectionally on microtubules, and this motility can be stimulated by overexpression of the small GTPase Arl8. By using affinity chromatography, we find that Arl8-GTP binds to the soluble protein SKIP (SifA and kinesin-..
  20. doi Interconversion of two GDP-bound conformations and their selection in an Arf-family small G protein
    Hideyasu Okamura
    Division of Plant Sciences, National Institute of Agrobiological Sciences, 2 1 2, Kannondai, Tsukuba, Ibaraki 305 8602, Japan
    Structure 19:988-98. 2011
    ..Herein, we report a study of the dynamics of an Arf-family protein, Arl8, under various conditions by means of NMR relaxation spectroscopy...
  21. pmc Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study
    Mi Ryung Han
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Neurol 10:90. 2010
    ..We carried out a genome-wide association study (GWAS) in order to better define the genetic backgrounds to these three states in relation to CSF levels...
  22. pmc The arf-like GTPase Arl8 mediates delivery of endocytosed macromolecules to lysosomes in Caenorhabditis elegans
    Isei Nakae
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Biol Cell 21:2434-42. 2010
    ..These findings suggest that ARL-8 mediates delivery of endocytosed macromolecules to lysosomes by facilitating late endosome-lysosome fusion...
  23. doi The epithelial membrane protein 1 is a novel tight junction protein of the blood-brain barrier
    Thorsten Bangsow
    Department of Molecular Haematology, University of Frankfurt Medical School, Frankfurt Main, Germany
    J Cereb Blood Flow Metab 28:1249-60. 2008
    ..The study identifies EMP1 as a novel TJ-associated protein of the BBB and suggests its potential role in the regulation of the BBB function in cerebral ischemia...
  24. ncbi Arf family GTPases: roles in membrane traffic and microtubule dynamics
    R A Kahn
    Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, GA 30322 3050, USA
    Biochem Soc Trans 33:1269-72. 2005
    ..six Arf family members were found in very early eukaryotes, including orthologues of Arf, Sar, Arl2, Arl3, Arl6 and Arl8. While roles for Arfs in membrane traffic are well known, those for most of the Arls remain unknown...
  25. ncbi Identification and characterization of LASP2 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 12:405-10. 2003
    ..Some part of the LASP2/ NEBL-TEM7L-ARL8-CACNB2 locus on 10p12 was paralogous to the LASP1-TEM7-CACNB1 locus on 17q12, while the other part of the LASP2/..
  26. ncbi Isolation of a new member of the ADP-ribosylation like factor gene family, ARL8, from a cartilage cDNA library
    Eiman Sebald
    Department of Obstetrics and Gynecology, Burns and Allen Cedars Sinai Research Institute, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Gene 311:147-51. 2003
    ..We have identified a new ARL, ARL8, from a fetal cartilage cDNA library...

Research Grants4

  1. Kang Shen; Fiscal Year: 2014
    ..transport and synapse localization through the regulation of molecular motors, and 2) how an ARF like GTPase, ARL8 regulate the synaptic vesicle pool size and presynaptic assembly...
  2. Michael B Brenner; Fiscal Year: 2014
    ..for the first time, that novel members of the Ras family of small GTPases, called Arl proteins, in particular Arl8, are essential regulators of lysosomal trafficking that is important in antigen presentation and phago-lysosome ..
  3. ARF BINDING IN THE ACTION OF CHOLERA AND E COLI TOXINS
    Richard Kahn; Fiscal Year: 2002
    ....
  4. ARL2: Regulator of Cytoskeleton and Mitochondria
    Richard Kahn; Fiscal Year: 2007
    ..And finally, relating these functions and mechanisms to those of the Arfs should also reveal important similarities and differences within the Arf family. [unreadable] [unreadable]..