ARID1B

Summary

Gene Symbol: ARID1B
Description: AT-rich interaction domain 1B
Alias: 6A3-5, BAF250B, BRIGHT, CSS1, DAN15, ELD/OSA1, MRD12, OSA2, P250R, AT-rich interactive domain-containing protein 1B, ARID domain-containing protein 1B, AT rich interactive domain 1B (SWI1-like), BRG1-associated factor 250b, BRG1-binding protein ELD/OSA1, ELD (eyelid)/OSA protein
Species: human

Top Publications

  1. doi Mutations in SWI/SNF chromatin remodeling complex gene ARID1B cause Coffin-Siris syndrome
    Gijs W E Santen
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Nat Genet 44:379-80. 2012
  2. ncbi Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits
    M L Phelan
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
    Mol Cell 3:247-53. 1999
  3. pmc Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control
    Norman G Nagl
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    EMBO J 26:752-63. 2007
  4. ncbi Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors
    Hiroko Inoue
    Department of Microbiology and Kaplan Cancer Center, New York University School of Medicine, New York 10016 6481, USA
    J Biol Chem 277:41674-85. 2002
  5. pmc Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B
    Xuan Shirley Li
    Department of Microbiology, Howard Hughes Medical Institute, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mol Cell Biol 30:1673-88. 2010
  6. pmc Two related ARID family proteins are alternative subunits of human SWI/SNF complexes
    Xiaomei Wang
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Biochem J 383:319-25. 2004
  7. pmc Target genes of the largest human SWI/SNF complex subunit control cell growth
    Hiroko Inoue
    Department of Microbiology and NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016 6481, U S A
    Biochem J 434:83-92. 2011
  8. pmc Ischemia induces early expression of a new transcription factor (6A3-5) in kidney vascular smooth muscle cells: studies in rat and human renal pathology
    Gwenaele Garin
    INSERM XR331, EA 1582 Génomique Fonctionnelle de l Athérothrombose, Faculte de Medecine Laennec, Lyon, France
    Am J Pathol 163:2485-94. 2003
  9. ncbi [A case of non-photosensitive, self-induced epileptic seizures with pacygyria]
    H Nagai
    Department of Pediatrics, Maizuru Hospital of Self Defense Force, Kyoto
    No To Hattatsu 30:417-22. 1998
  10. ncbi The eyes of deep-sea fish. I: Lens pigmentation, tapeta and visual pigments
    R H Douglas
    Department Optometry and Visual Science, City University, London
    Prog Retin Eye Res 17:597-636. 1998

Detail Information

Publications452 found, 100 shown here

  1. doi Mutations in SWI/SNF chromatin remodeling complex gene ARID1B cause Coffin-Siris syndrome
    Gijs W E Santen
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Nat Genet 44:379-80. 2012
    We identified de novo truncating mutations in ARID1B in three individuals with Coffin-Siris syndrome (CSS) by exome sequencing...
  2. ncbi Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits
    M L Phelan
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
    Mol Cell 3:247-53. 1999
    ..The addition of INI1, BAF155, and BAF170 to BRG1 increases remodeling activity to a level comparable to that of the whole hSWI/SNF complex. These data define the functional core of the hSWI/SNF complex...
  3. pmc Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control
    Norman G Nagl
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    EMBO J 26:752-63. 2007
    ..The specific complexes control access of factors such as E2F1, Tip60, and HDAC1/2/3 to the promoters of various cell-cycle-specific genes, with c-Myc emerging as a particularly critical target...
  4. ncbi Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors
    Hiroko Inoue
    Department of Microbiology and Kaplan Cancer Center, New York University School of Medicine, New York 10016 6481, USA
    J Biol Chem 277:41674-85. 2002
    ..These results suggest that hOsa1 and hOsa2 participate in promoting transcriptional activation by the steroid hormone receptors...
  5. pmc Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B
    Xuan Shirley Li
    Department of Microbiology, Howard Hughes Medical Institute, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mol Cell Biol 30:1673-88. 2010
    ..The characteristic member of human SWI/SNF-A is BAF250/ARID1, of which there are two isoforms, BAF250a/ARID1a and BAF250b/ARID1b...
  6. pmc Two related ARID family proteins are alternative subunits of human SWI/SNF complexes
    Xiaomei Wang
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Biochem J 383:319-25. 2004
    ..b>ARID1B is an independent gene product with an open reading frame that is more than 60% identical with p270...
  7. pmc Target genes of the largest human SWI/SNF complex subunit control cell growth
    Hiroko Inoue
    Department of Microbiology and NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016 6481, U S A
    Biochem J 434:83-92. 2011
    ..BRG1-associated factor) chromatin-remodelling complex is encoded by two related cDNAs hOsa1/BAF250a and hOsa2/BAF250b that are unique to the BAF complex and absent in the related PBAF (Polybromo BAF)...
  8. pmc Ischemia induces early expression of a new transcription factor (6A3-5) in kidney vascular smooth muscle cells: studies in rat and human renal pathology
    Gwenaele Garin
    INSERM XR331, EA 1582 Génomique Fonctionnelle de l Athérothrombose, Faculte de Medecine Laennec, Lyon, France
    Am J Pathol 163:2485-94. 2003
    ..Transcription factor 6A3-5 could potentially be a novel early vascular marker of acute and chronic renal ischemic stress implicated in tissue remodeling...
  9. ncbi [A case of non-photosensitive, self-induced epileptic seizures with pacygyria]
    H Nagai
    Department of Pediatrics, Maizuru Hospital of Self Defense Force, Kyoto
    No To Hattatsu 30:417-22. 1998
    ..of consciousness in himself by waving his right hand over his face which was directed toward a source of bright light. At the age of seven, he developed spontaneous seizures with impairment of consciousness...
  10. ncbi The eyes of deep-sea fish. I: Lens pigmentation, tapeta and visual pigments
    R H Douglas
    Department Optometry and Visual Science, City University, London
    Prog Retin Eye Res 17:597-636. 1998
    ..given the fact that they live in a photon limited environment, the lenses of some deep-sea teleosts are bright yellow, absorbing much of the shortwave part of the spectrum...
  11. ncbi [Natural evolution of neurocutaneous syndrome in adults]
    A Pou Serradell
    Servicio de Neurologia, Hospital Universitario del Mar, Barcelona
    Rev Neurol 24:1085-127. 1996
    ..much less aggressive than non-NF1 brainstem tumors but more symptomatic than brainstem UBOs ('unidentified bright objects') in NF1...
  12. ncbi Differences in protein patterns of gill epithelial cells of the fish Gillichthys mirabilis after osmotic and thermal acclimation
    D Kultz
    Department of Zoology, Oregon State University, Corvallis 97331 2914, USA
    J Comp Physiol B 166:88-100. 1996
    ..Chloride cells were identified on the basis of size (> 10 microns) and bright appearance after [2-(p-dimethylaminostyryl)-1-methyl-pyridinium-iodine] staining...
  13. ncbi Ultrastructural dynamics of mitochondrial morphology in varying functional forms of human adrenal cortical adenoma
    S R Bornstein
    Department of Internal Medicine III, University of Leipzig, Federal Republic of Germany
    Horm Metab Res 28:177-82. 1996
    ..of 21 alpha-hydroxylase activity was demonstrated, showed a peculiar type of enlarged lamellar mitochondria with bright inner matrix and a reduced number of inner membranes...
  14. ncbi [A case of bilateral coronal craniosynostosis with the P250R mutation in FGFR3 gene]
    F Mori
    Department of Pediatrics, Ibaraki Handicapped Children's Hospital, Mito, Ibaraki
    No To Hattatsu 33:53-7. 2001
    ..We report a 1-year-1-month-old female with bilateral coronal craniosynostosis who had the P250R mutation in FGFR3 gene detected by DNA sequencing...
  15. ncbi [Partial seizures following aseptic meningoencephalitis: an unusual case]
    M Satoh
    Department of Pediatrics, Niigata City General Hospital
    No To Hattatsu 29:326-30. 1997
    ..Thirty-six days after admission, MRI showed multiple dark areas on T1-weighted images and bright areas on T2-weighted images in the bilateral frontal area...
  16. ncbi Migraine, as compared to other headaches, is worse during midnight-sun summer than during polar night. A questionnaire study in an Arctic population
    R Salvesen
    Department of Neurology, , , Norway
    Headache 40:824-9. 2000
    ..002). CONCLUSIONS: Patients with migraine were more likely to have headache during the bright Arctic summer season, and this distinguishes migraine from other headaches in this study...
  17. ncbi Growth factor receptor expression during in vitro differentiation of partially purified populations containing murine stem cells
    E Ashihara
    Laboratory of Hematopoietic Growth Factors, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
    J Cell Physiol 171:343-56. 1997
    ..Rho) into Rho-dull (> or = 17% of which reconstitute long-term hematopoiesis in recipient mice) and into Rho-bright (which are as capable as Rho-dull of multilineage differentiation but do not permanently reconstitute the host)...
  18. ncbi [A case of childhood epilepsy with occipital paroxysms (CEOP) presenting particular EEG findings]
    N Iwasaki
    Department of Pediatrics, University of Tsukuba, Ibaraki
    No To Hattatsu 24:364-9. 1992
    ..of visual field for 10 to 20 seconds, as if a curtain had fallen following the visual hallucination of a bright light spot. At the age of eight years, he was admitted to our hospital for evaluation and therapy...
  19. ncbi Downregulation of ATP synthase subunit-6, cytochrome c oxidase-III, and NADH dehydrogenase-3 by bright cyclic light in the rat retina
    Hu Huang
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    Invest Ophthalmol Vis Sci 45:2489-96. 2004
    Retinas of albino rats born and raised in bright cyclic light (300-800 lux) are less susceptible to light-induced apoptosis than retinas of animals born and raised in dim cyclic light (5 lux)...
  20. ncbi Clinical and demographic characteristics of migraine in urban children
    L H Lee
    Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, OH 44106, USA
    Headache 37:269-76. 1997
    ..were mostly pulsating, poorly localized, lasted about 2 to 12 hours, and were aggravated by motion, noise, and bright light. The associated symptoms were nausea, vomiting, photophobia, and phonophobia...
  21. ncbi Quantitative analysis of edema in the dorsal nerve roots induced by acute mechanical compression
    T Matsui
    Department of Orthopaedic Surgery, Kanazawa University, Ishikawa, Japan
    Spine (Phila Pa 1976) 23:1931-6. 1998
    ..Changes in edema were examined using fluorescence microscopy. Evans blue albumin emits a bright red fluorescence...
  22. ncbi Peculiarities of dermatomyositis (DM) in early age
    T V Ryabova
    First Moscow Medical Institute, USSR
    Acta Univ Carol Med (Praha) 37:3-5. 1991
    ..An acute onset of dermatomyositis was characterized by fever, myaglia, arthralgia, bright skin symptoms: widespread purple violet face erythema, a "butterfly wing" or "paraorbital glasses", palmal ..
  23. ncbi Light adaptation and sensitivity controlling mechanisms in vertebrate photoreceptors
    I Perlman
    Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
    Prog Retin Eye Res 17:523-63. 1998
    ..discriminate increment and decrement light stimuli over a wide range of ambient illumination; from moonlight to bright sunlight...
  24. ncbi Comparison of enzyme-linked immunosorbent assay and indirect fluorescent antibody test for the detection of IgG antibodies to Sarcocystis muris
    A M Tenter
    , , Federal Republic of Germany
    Zentralbl Bakteriol Mikrobiol Hyg A 267:259-71. 1987
    ..antibodies between 11 and 25 dpi starting with fluorescence at the apical pole of the cystozoite and resulting in bright fluorescence of the whole cystozoite from 32 or 35 dpi onwards...
  25. doi Intracoronary optical coherence tomography and histology at 1 month and 2, 3, and 4 years after implantation of everolimus-eluting bioresorbable vascular scaffolds in a porcine coronary artery model: an attempt to decipher the human optical coherence tomo
    Yoshinobu Onuma
    Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands
    Circulation 122:2288-300. 2010
    ..We therefore report OCT findings with corresponding histology in the porcine coronary artery model immediately after and at 28 days and 2, 3, and 4 years after BVS implantation...
  26. ncbi Acute spinal cord injury. A study using physical examination and magnetic resonance imaging
    F J Bondurant
    Division of Orthopaedic Surgery, University of Texas Medical School, Houston
    Spine (Phila Pa 1976) 15:161-8. 1990
    ..Type II, seen in 16 (43.2%) of the patients, demonstrated a bright signal intensity consistent with acute cord edema. Type III, seen in three (8...
  27. ncbi The ONS Longitudinal Study - a prestigious past and a bright future
    Shayla Goldring
    Office for National Statistics
    Popul Trends 139:4-10. 2010
    ..Please refer to the contact details at the end of the article if you require further information on any of the three longitudinal studies...
  28. ncbi Green light attenuates melatonin output and sleepiness during sleep deprivation
    J A Horne
    Department of Human Sciences, Loughborough University, Leicestershire
    Sleep 14:233-40. 1991
    Melatonin output covaries with sleepiness, with both peaking early morning. Bright white light suppresses this output, but it is not known if such treatment ameliorates nighttime sleepiness during sleep deprivation...
  29. ncbi Leukemia cutis in three children: clinical and immunohistochemical studies
    M Koga
    Department of Pediatrics, Yamaguchi University School of Medicine, Japan
    Pediatr Dermatol 13:200-6. 1996
    ..lesions were tumors and areas of reddish purple erythema in the first child, pigmented erythema in the second, and bright red erythema in the first child, pigmented erythema in the second, and bright red erythema in the third...
  30. ncbi Trichothiodystrophy: ultrastructural studies of two patients
    S Calvieri
    Department of Dermatology, University of Rome La Sapienza, Italy
    Pediatr Dermatol 10:111-6. 1993
    ..Microscopic observation of the hair under polarized light showed typical alternation of bright and dark bands; amino acid analysis of the hair demonstrated a marked reduction of cystine levels...
  31. ncbi Quantification of apoptosis and necrosis by flow cytometry
    M G Ormerod
    MRC Toxicology Unit, Carshalton, Surrey, England
    Acta Oncol 32:417-24. 1993
    ..UV radiation, dead cells fluoresced red due to the uptake of propidium iodide whereas apoptotic cells fluoresced bright blue; normal cells showed low blue, low red fluorescence...
  32. ncbi Improving adaptation to simulated night shift: timed exposure to bright light versus daytime melatonin administration
    D Dawson
    Department of Obstetrics and Gynaecology, Queen Elizabeth Hospital University of Adelaide, South Australia
    Sleep 18:11-21. 1995
    ..In recent years, appropriately timed exposure to bright light and exogenous melatonin have been used to accelerate adaptation to phase shifts of the circadian system...
  33. ncbi Blood hemolysis by PTFE and polyurethane vascular prostheses in an in vitro circuit
    H Martz
    Laboratory of Experimental Surgery, Laval University, , Canada
    J Biomed Mater Res 21:1187-96. 1987
    In order to improve understanding of the appearance of bright yellow stains in vivo (consecutive to the absorption of bilirubin) on a novel microporous, hydrophilic polyetherurethaneurea vascular prosthesis, the in vitro hemolytic ..
  34. ncbi Visual performance with multifocal intraocular lenses: mesopic contrast sensitivity under distance and near conditions
    Robert Montes-Mico
    Optometry and Vision Sciences Unit, University of Valencia, Valencia, Spain
    Ophthalmology 111:85-96. 2004
    To evaluate distance and near visual performance under bright (photopic) and dim (mesopic) conditions in patients who had undergone uncomplicated cataract extraction with multifocal or monofocal intraocular lens (IOL) implantation.
  35. ncbi Medium-intensity light produces circadian rhythm adaptation to simulated night-shift work
    S K Martin
    Biological Rhythms Research Lab, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Ill. 60612, USA
    Sleep 21:154-65. 1998
    ..Larger phase shifts were correlated with more sleep and less fatigue. CONCLUSIONS: Extremely "bright" light may not be necessary for circadian adaptation in shift work situations similar to our study protocol (e.g...
  36. ncbi Safety and efficacy of nasogastric intubation for gastrointestinal bleeding after myocardial infarction: an analysis of 125 patients at two tertiary cardiac referral hospitals
    Mitchell S Cappell
    Gastroenterology Fellowship Training Program, Division of Gastroenterology, Department of Medicine, Albert Einstein Medical Center, Klein Professional Building, Suite 363, 5401 Old York Road, Philadelphia, Pennsylvania 19141, USA
    Dig Dis Sci 50:2063-70. 2005
    ..occult blood with an acute hematocrit decline, severe anemia, or sudden hypotension in 37; hematemesis in 18; bright red blood per rectum in 8; and dark red blood per rectum in 7. The intubation was performed on average 5.3 +/- 7...
  37. ncbi Bright light treatment: are we keeping our subjects in the dark?
    D Dawson
    Institute for Circadian Physiology, Boston, Massachusetts
    Sleep 13:267-71. 1990
    b>Bright light treatments for seasonal affective disorder (SAD) and phase-disturbed circadian rhythms show considerable interindividual variation in response...
  38. ncbi Detection of calcifications in breast biopsies by scanning electron microscopy
    J A Terzakis
    Department of Pathology, Lenox Hill Hospital, New York, NY 10021, USA
    Ultrastruct Pathol 22:181-4. 1998
    ..The present study demonstrates how conventional bright-field and polariscopic light microscopy did require considerable effort to confirm rare calcification...
  39. ncbi Effects of chloroquine on the photosensory membrane turnover and the ultrastructure of lysosome-related bodies of the crayfish photoreceptor
    U Schraermeyer
    , RWTH Aachen, Bundesrepublik Deutschland
    Z Naturforsch C 47:420-8. 1992
    The effect of chloroquine in combination with bright light on the ultrastructure of crayfish (Orconectes limosus R.) photoreceptors was investigated in vivo. Chloroquine had several effects upon the crayfish retina...
  40. ncbi The relationship of variations in children's growth rates to seasonal climatic variations
    W A Marshall
    Department of Growth and Development, Institute of Child Health, University of London
    Ann Hum Biol 2:243-50. 1975
    ..32) for the boys and with hours of bright sunshine (-0.29) for the girls...
  41. pmc Schwan equation and transmembrane potential induced by alternating electric field
    P Marszalek
    Department of Biochemistry, University of Minnesota College of Biological Sciences, St Paul 55108
    Biophys J 58:1053-8. 1990
    ..The dye diffused into the cell, giving rise to two bright, narrow bands, which expanded to the whole cell in 1-3 min...
  42. ncbi Variations in circadian rhythms of activity, sleep, and light exposure related to dementia in nursing-home patients
    S Ancoli-Israel
    Department of Psychiatry, University of California San Diego, USA
    Sleep 20:18-23. 1997
    ..In addition, the severely demented patients spent less time exposed to bright light...
  43. ncbi The use of visual information by house flies, Musca domestica (Diptera: muscidae), foraging in resource patches
    D Conlon
    Department of Entomology, University of Kansas, Lawrence 66045 2106
    J Comp Physiol A 168:365-71. 1991
    ..Various substrate contrasts are effective as resource information for flies: dark (e.g., green) figures on bright (e.g., white) backgrounds or bright figures on dark backgrounds...
  44. doi Visual performance with sport-tinted contact lenses in natural sunlight
    Graham B Erickson
    Pacific University College of Optometry, OR 97116, USA
    Optom Vis Sci 86:509-16. 2009
    ..This study broadens previous research regarding performance-tinted CLs and their effects on measures of visual performance...
  45. doi Role of chemokines in the biology of natural killer cells
    Azzam A Maghazachi
    Department of Physiology, Faculty of Medicine, Institute of Basic Medical Sciences, Blindern, 0317 Oslo, Norway
    Curr Top Microbiol Immunol 341:37-58. 2010
    ..In human blood, NK cells are divided into CD56(bright) CD16(dim) and CD56(dim) CD16(bright) subsets...
  46. ncbi Dynamics of EEG slow-wave activity and core body temperature in human sleep after exposure to bright light
    C Cajochen
    Institute of Pharmacology, , Switzerland
    Sleep 15:337-43. 1992
    In seven subjects sleep was recorded after a single 3-hour (2100-0000 hours) exposure to either bright light (BL, approx. 2,500 lux) or dim light (DL, approx. 6 lux) in a crossover design. The latency to sleep onset was increased after BL...
  47. pmc A family of GFP-like proteins with different spectral properties in lancelet Branchiostoma floridae
    Diana Baumann
    Stowers Institute for Medical Research, 1000 E 50th St, Kansas City, MO 64110, USA
    Biol Direct 3:28. 2008
    ..Fluorescence or bright coloration, observed in many members of this family, is enabled by the intrinsic properties of the polypeptide ..
  48. ncbi Calcium requirement and time course of capacitation of goat spermatozoa assessed by chlortetracycline assay
    G Kaul
    Department of Biochemistry, National Dairy Research Institute, Karnal, India
    Andrologia 29:243-51. 1997
    ..Categorised according to nomenclature reported earlier, these are: 'F' with bright fluorescence in the postacrosomal region, characteristic of uncapacitated acrosomal-intact cells; 'B' with bright ..
  49. ncbi [Value of magnetic resonance imaging in a lipoma of the left ventricle]
    J E Wolf
    Clinique cardiologique, CHU, Grenoble
    Arch Mal Coeur Vaiss 80:1801-5. 1987
    ..With MRI spin-echo sequences the lipoma emitted a bright signal similar to that of normal fatty tissue on the two echoes of the sequence (28 ms and 65 ms)...
  50. ncbi Non-24-hour sleep-wake syndrome in a sighted man: circadian rhythm studies and efficacy of melatonin treatment
    A J McArthur
    Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland 97201, USA
    Sleep 19:544-53. 1996
    ..Thus, the patient appeared to be subsensitive to bright light. A 4-week trial of daily melatonin administration (0...
  51. ncbi Effects of timed bright-light exposure on shift-work adaptation in middle-aged subjects
    S S Campbell
    Department of Psychiatry, Cornell University Medical College, White Plains, New York, USA
    Sleep 18:408-16. 1995
    ..Recently, a number of studies have demonstrated that timed exposure to bright light can help facilitate adaptation to simulated shift-work schedules, at least in younger subjects...
  52. ncbi The effect of evening bright light in delaying the circadian rhythms and lengthening the sleep of early morning awakening insomniacs
    L Lack
    Sleep Laboratory, Flinders University of South Australia, Adelaide
    Sleep 16:436-43. 1993
    ..Because bright light stimulation in the evening can delay the phase of circadian rhythms, we tested its effects on nine (4 ..
  53. ncbi Effect of melatonin suppression on scoliosis development in chickens by either constant light or surgical pinealectomy
    Kenneth M C Cheung
    Department of Orthopaedic Surgery, The University of Hong Kong, Hong Kong, China
    Spine (Phila Pa 1976) 28:1941-4. 2003
    This study was designed to compare the effect of suppression of melatonin secretion by bright light in chickens with that of surgical pinealectomy.
  54. ncbi Effects of light treatment on sleep structure in seasonal affective disorder
    T Partonen
    Ullanlinna Sleep Disorders Clinic and Research Centre, Helsinki, Finland
    Eur Arch Psychiatry Clin Neurosci 242:310-3. 1993
    Twelve outpatients with seasonal affective disorder (depression, winter type) were treated by 1 h of bright light exposure for five mornings...
  55. ncbi Sleep deprivation and bright light as potential augmenters of antidepressant drug treatment--neurobiological and psychometric assessment of course
    E Holsboer-Trachsler
    Department of Psychiatry, University of Basle, Switzerland
    J Psychiatr Res 28:381-99. 1994
    ..study was designed to investigate the clinical efficacy of trimipramine with adjunct sleep deprivation (SD) or bright light (BL) and to evaluate psychometric and neurobiological variables that might be of predictive value for ..
  56. ncbi Melanin protects choroidal blood vessels against light toxicity
    Swaantje Peters
    Center of Ophthalmology, University of Tuebingen, Schleichstr 12, D 72076 Tuebingen, Germany
    Z Naturforsch C 61:427-33. 2006
    Low ocular pigmentation and high long-term exposure to bright light are believed to increase the risk of developing age-related macular degeneration (ARMD)...
  57. ncbi Constant bright light (LL) during lactation in rats prevents arrhythmicity due to LL
    T Cambras
    Unitat Fisiologia, Facultat Farmacia, Universitat de Barcelona, Spain
    Physiol Behav 63:875-82. 1998
    ..LD) cycles are the main zeitgebers for practically all organisms, and the exposure of animals to constant bright light (LL) alters the manifestation of circadian rhythms...
  58. ncbi Simple enumerations of peripheral blood natural killer (CD56+ NK) cells, B cells and T cells have no predictive value in IVF treatment outcome
    M Y Thum
    Lister Fertility Clinic, Lister Hospital, London, UK
    Hum Reprod 20:1272-6. 2005
    ..the absolute counts of the peripheral natural killer (NK) cells (including total CD56(+) NK cells, CD56(dim) NK cells and CD56(bright) NK cells), B cells and T cells on the implantation rate and miscarriage rate after IVF treatment.
  59. ncbi Histopathologic approaches to chemical toxicity using primary cultures of dissociated neural cells grown in chamber slides
    B Bolon
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 21:465-79. 1993
    ..primary dissociated cerebrocortical cell cultures from fetal mice were examined using phase-contrast and bright-field microscopy...
  60. ncbi Augmentation of antidepressants with bright light therapy in patients with comorbid depression and borderline personality disorder
    Jan Prasko
    Department of Psychiatry, University Hospital Olomouc, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 154:355-61. 2010
    ..Both sleep and diurnal rhythms are disturbed and the symptoms fluctuate. Bright light may be an effective in treatment of seasonal affective disorder, circadian sleep disorder and jet lag...
  61. ncbi Characterization of the reflective materials and organelles in the bright irides of North American blackbirds (Icterinae)
    J Hudon
    Department of Veterinary Anatomy, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada
    Pigment Cell Res 9:96-104. 1996
    The reflective materials in the iris stroma of bright-irised American blackbirds (Icterinae, Emberizidae) and the red-eyed vireo (vireo olivaceus) (Vireonidae) were characterized using high-performance liquid chromatography (HPLC) and ..
  62. ncbi Aircraft accidents and incidents associated with visual effects from bright light exposures during low-light flight operations
    Van B Nakagawara
    Federal Aviation Administration, Civil Aerospace Medical Institute, Oklahoma City, OK 73105, USA
    Optometry 78:415-20. 2007
    ..This study investigates operational problems experienced by civilian airmen exposed to bright light sources while performing nighttime aviation activities.
  63. ncbi Precipitating factors in migraine: a retrospective review of 494 patients
    L Robbins
    Rush Medical College, Northbrook, IL
    Headache 34:214-6. 1994
    ..Stress (62%) was the most frequently cited precipitant. Weather changes (43%), missing a meal (40%), and bright sunlight (38%) were also prominent factors...
  64. doi Diagnostic value of dynamic contrast-enhanced MRI for unilocular cystic-type ameloblastomas with homogeneously bright high signal intensity on T2-weighted or STIR MR images
    Miki Hisatomi
    Department of Oral and Maxillofacial Radiology, Field of Tumor Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 5 1, Shikata cho, 2 chome, Kita ku, Okayama 700 8525, Japan
    Oral Oncol 47:147-52. 2011
    ..images of ameloblastomas on T2-weighted image (WI) or short inversion time inversion-recovery (STIR) show multiple bright high-signal-intensity loci on a high-signal-intensity background...
  65. ncbi A visually evoked escape response of the housefly
    M H Holmqvist
    Centre for Visual Sciences, Australian National University, Canberra A C T
    J Comp Physiol A 169:451-9. 1991
    ..On the other hand, a bright disk elicits escape only when it recedes...
  66. ncbi Evening administration of melatonin and bright light: interactions on the EEG during sleep and wakefulness
    C Cajochen
    Psychiatric University Clinic, Basel, Switzerland
    J Sleep Res 7:145-57. 1998
    ..o. at 20.40 hours) with or without a 3-h bright light exposure (5000 lux from 21.00 hours-24...
  67. ncbi Loss of the circadian rhythms of locomotor activity, food intake, and plasma melatonin concentration induced by constant bright light in the pigeon (Columba livia)
    H Yamada
    Department of Animal Physiology, Faculty of Agriculture, Nagoya University, Japan
    J Comp Physiol A 163:459-63. 1988
    ..activity were measured together with circulating levels of melatonin in pigeons which were exposed to constant bright light (LLbright, 2000 lux) following light-dark (LD) cycles...
  68. ncbi Disruption of sleep recovery after 36 hours of exposure to moderately bright light
    A Daurat
    Laboratoire d'Etude du Sommeil, INSERM U 296, , France
    Sleep 20:352-8. 1997
    Eight young adults were exposed to either 36 hours of moderate bright light (BL; 1,000-2,000 lux) or a light/dark cycle (L/D < 50 lux) during constant routine...
  69. doi Bright-field in situ hybridization for HER2 gene amplification in breast cancer using tissue microarrays: correlation between chromogenic (CISH) and automated silver-enhanced (SISH) methods with patient outcome
    Glenn D Francis
    Pathology Queensland, Princess Alexandra Hospital, Woolloongabba, Australia
    Diagn Mol Pathol 18:88-95. 2009
    ..In situ hybridization is required to be eligible for adjuvant treatment with trastuzumab in Australia. Bright-field in situ hybridization is an alternative to FISH and uses a combination of in situ methodology and a ..
  70. ncbi Phase-shifting effects of bright morning light as treatment for delayed sleep phase syndrome
    N E Rosenthal
    Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Maryland 20892
    Sleep 13:354-61. 1990
    b>Bright light has recently been shown to have phase-shifting effects on human circadian rhythms...
  71. ncbi Characteristics of migraine visual aura
    L P Queiroz
    University Hospital, UFSC, Florianopolis, SC, Brazil
    Headache 37:137-41. 1997
    ..They started in the periphery of the visual fields in 56%. The most common phenomena described were: small bright dots (42%), flashes of light (39%), "blind spots" (32%), and "foggy vision" (27%)...
  72. ncbi Enhancing effect of UV-light on the accumulation of carthamine in dyer's saffron florets
    K Saito
    Department of Bioscience and Technology, School of Engineering, Hokkaido Tokai University, Sapporo, Japan
    Z Naturforsch C 51:667-70. 1996
    UV-C (254 nm)- and UV-B (280-320 nm)-light were irradiated onto bright-yellow capitula of dyer's saffron and their effects on carthamine accumulation compared...
  73. ncbi Bright light treatment decreases depression in institutionalized older adults: a placebo-controlled crossover study
    I C Sumaya
    Laboratory of Psychobiochemistry, University of Texas at El Paso, USA
    J Gerontol A Biol Sci Med Sci 56:M356-60. 2001
    ..at least in part, for some depression among institutionalized older adults, the aim of this study was to investigate the efficacy of morning bright light treatment on depression among older adults residing in a long-term care facility.
  74. ncbi Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients
    Hui Yang
    Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Fertil Steril 89:656-61. 2008
    ..To investigate the proportional changes of CD4(+)CD25(+) regulatory T cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion (URSA) and normal pregnant (NP) women...
  75. ncbi Interobserver interpretative reproducibility of GOLDFISH, a first generation gold-facilitated autometallographic bright field in situ hybridization assay for HER-2/neu amplification in invasive mammary carcinoma
    Raymond Tubbs
    Department Clinical Pathology, Cleveland Clinic Foundation, Ohio 44195 5131, USA
    Am J Surg Pathol 26:908-13. 2002
    ..A bright field alternative permitting direct visualization of gene amplification using conventional microscopy may be more ..
  76. ncbi Bright-light mask treatment of delayed sleep phase syndrome
    Roger J Cole
    Synchrony Applied Health Sciences, Del Mar, CA 92014 3805, USA
    J Biol Rhythms 17:89-101. 2002
    ..Volunteers received either bright white light (2,700 lux, n = 28) or dim red light placebo (0.1 lux, n = 26) for 26 days at home...
  77. ncbi A controlled trial of timed bright light and negative air ionization for treatment of winter depression
    M Terman
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York 10032, USA
    Arch Gen Psychiatry 55:875-82. 1998
    Artificial bright light presents a promising nonpharmacological treatment for seasonal affective disorder. Past studies, however, have lacked adequate placebo controls or sufficient power to detect group differences...
  78. doi Close association of CD8+/CD38 bright with HIV-1 replication and complex relationship with CD4+ T-cell count
    Edouard Tuaillon
    Laboratoire de Virologie, Centre Hospitalier Universitaire de Montpellier, France
    Cytometry B Clin Cytom 76:249-60. 2009
    ..Focusing specifically on CD38 high expression (CD8(+)/CD38(bright)) may be an interesting surrogate gating strategy because CD38(bright) characterizes principally activated memory ..
  79. ncbi Bright and dark excitons in semiconductor carbon nanotubes: insights from electronic structure calculations
    Svetlana Kilina
    Theoretical Division, Center for Nonlinear Studies CNLS, and Center for Integrated Nanotechnologies CINT, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Phys Chem Chem Phys 11:4113-23. 2009
    ..We specifically focus on the energy splitting, relative ordering, and localization properties of optically active (bright) and optically forbidden (dark) states from the lowest excitonic band of the nanotubes...
  80. ncbi Controlled trial of bright light and negative air ions for chronic depression
    Namni Goel
    Department of Psychology, 207 High Street, Judd Hall, Wesleyan University, Middletown, CT 06459, USA
    Psychol Med 35:945-55. 2005
    This randomized controlled trial investigates the efficacy of two non-pharmacologic treatments, bright light and high-density negative air ions for non-seasonal chronic depression...
  81. ncbi Effects of color temperature of illumination on physiological functions
    Tetsuo Katsuura
    Ergonomics Section, Faculty of Engineering, Chiba University, Chiba, Japan
    J Physiol Anthropol Appl Human Sci 24:321-5. 2005
    ..recent studies on the effects of color temperature on the taste sense and the influence of color temperature on bright light exposure during night rest period...
  82. ncbi Supplementary dim light differentially influences sexual maturity, oviposition time, and melatonin rhythms in pullets
    P D Lewis
    Department of Clinical Veterinary Science, University of Bristol, Langford, United Kingdom
    Poult Sci 80:1723-8. 2001
    ..09 lx) immediately before or after the main 8-h photoperiod. The bright/dim and dim/ bright groups matured at the same age, thus disproving the hypothesis tested...
  83. ncbi The discovery of diabetic nephropathy: from small print to centre stage
    J S Cameron
    Renal Medicine Department of Nephrology and Transplantation, Guy s Hospital, King s College, London, UK
    J Nephrol 19:S75-87. 2006
    ..were debated, it was noted in parallel that diabetics might show coagulable urine containing albumin, even before Bright and others had established this as a sign of kidney disease...
  84. pmc A regulated nucleocytoplasmic shuttle contributes to Bright's function as a transcriptional activator of immunoglobulin genes
    Dongkyoon Kim
    University of Texas at Austin, Molecular Genetics and Microbiology, 1 University Station A5000, Room ESB 532, Austin, TX 78712 0162, USA
    Mol Cell Biol 26:2187-201. 2006
    b>Bright/ARID3a has been implicated in mitogen- and growth factor-induced up-regulation of immunoglobulin heavy-chain (IgH) genes and in E2F1-dependent G1/S cell cycle progression...
  85. ncbi Bright cyclic light accelerates photoreceptor cell degeneration in tubby mice
    Li Kong
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Neurobiol Dis 21:468-77. 2006
    ..in Tubby (homozygous tub/tub, which have inherited, progressive retinal degeneration) mice born and raised in a bright cyclic light environment...
  86. ncbi Cone photoreceptor oil droplet pigmentation is affected by ambient light intensity
    Nathan S Hart
    Vision, Touch and Hearing Research Centre, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
    J Exp Biol 209:4776-87. 2006
    ..Pigmented oil droplets are beneficial for colour discrimination in bright light, but at lower light levels the reduction in sensitivity caused by the pigmentation increasingly outweighs ..
  87. ncbi Bright light therapy for winter depression--is phase advancing beneficial?
    Helen J Burgess
    Biological Rhythms Research Laboratory, Department of Psychology, Rush University Medical Center, Chicago, IL 60612, USA
    Chronobiol Int 21:759-75. 2004
    b>Bright light is the recommended treatment for winter seasonal affective disorder (SAD). Previously we showed that the antidepressant effect of morning (but not evening) light was greater than placebo after 3 weeks of treatment...
  88. ncbi Acute phase proteins, body temperature and urinary melatonin under the influence of bright and dim light intensities during the daytime
    D Kanikowska
    Department of Environmental Health, Nara Women s University
    J Physiol Anthropol Appl Human Sci 20:333-8. 2001
    ..7 healthy volunteers under the influence of two different light intensities during the daytime dim (100 lx) and bright (3000 lx) light...
  89. ncbi Stem cell activity of human side population and alpha6 integrin-bright keratinocytes defined by a quantitative in vivo assay
    Atsushi Terunuma
    Dermatology Branch, National Cancer Institute NIH, Bldg 10 Room 12N260, 10 Center Drive MSC 1908, Bethesda, MD 20892 1908, USA
    Stem Cells 25:664-9. 2007
    ..When in vitro assays were used to measure total cell output of human SP-KCs and integrin-bright keratinocytes, we could not document their superior long-term proliferative activity versus unfractionated ..
  90. ncbi Daytime sleep propensity after moderate circadian phase shifts induced with bright light exposure
    M Dumont
    Laboratoire de chronobiologie, , , Canada
    Sleep 20:11-7. 1997
    Moderate circadian phase shifts were induced by 3 days of bright light exposure, without changing the habitual sleep schedule...
  91. ncbi Bright light treatment of winter depression: a placebo-controlled trial
    C I Eastman
    Department of Psychology, Rush Presbyterian St Luke s Medical Center, Chicago, Ill 60612, USA
    Arch Gen Psychiatry 55:883-9. 1998
    b>Bright light therapy is the recommended treatment for winter seasonal affective disorder (SAD)...
  92. ncbi IL-3-induced coexpression of histidine decarboxylase, IL-4 and IL-6 mRNA by murine basophil precursors
    E Schneider
    CNRS URA 1461, Universite Rene Descartes Paris V, Hopital Necker, France
    Exp Hematol 27:1010-8. 1999
    ..low-density bone marrow cells sorted from the blast cell window on the basis of high rhodamine-123 retention (Rh-bright), are highly enriched in histamine-, IL-4-, and IL-6-producing cells...
  93. ncbi Two- and 4-hour bright-light exposures differentially effect sleepiness and performance the subsequent night
    V C Thessing
    Sleep Disorders and Research Center, Deaconess Medical Center, St. Louis, MO 63139
    Sleep 17:140-5. 1994
    The effect of two durations of bright light upon sleepiness and performance during typical night shift hours was assessed. Thirty normal, healthy young adults participated in a 2-night protocol...
  94. ncbi The visual acuity of the frog (Rana pipiens)
    A C Aho
    Department of Biosciences, University of Helsinki, Finland
    J Comp Physiol A 180:19-24. 1997
    ..The acuity was tested in bright white light and with different brightness levels of green light (500 nm). The highest acuity 2...
  95. ncbi [The CO2 laser in otorhinolaryngology. Advantages as opposed to conventional surgery and current possibilities]
    B Vercruysse
    Dienst Neus, Oor- en Keelziekten, AZ Sint-Jan, Brugge
    Acta Otorhinolaryngol Belg 42:45-57. 1988
    The future of lasers in medicine in general and in otorhinolaryngology in specific appears to be bright. It's use is very simple, but may not weaken the wakefulness of its user. Skill and experience remain very important...
  96. ncbi A portable light source for bright light treatment
    I M McIntyre
    Department of Psychiatry, University of Melbourne, Heidelberg, Australia
    Sleep 13:272-5. 1990
    A novel, portable, inexpensive bright light source is described...
  97. pmc Conversion of red fluorescent protein into a bright blue probe
    Oksana M Subach
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Chem Biol 15:1116-24. 2008
    ....
  98. pmc Spatial filtering versus anchoring accounts of brightness/lightness perception in staircase and simultaneous brightness/lightness contrast stimuli
    Barbara Blakeslee
    Center for Visual Neuroscience, Department of Psychology, North Dakota State University, Fargo, ND 58108 6050, USA
    J Vis 9:22.1-17. 2009
    ..incremental targets in staircase simultaneous brightness/lightness contrast stimuli did not all appear equally bright/light; 3) an asymmetry due to a greater brightening/lightening of the target on the black surround was not general;..
  99. ncbi Outpatient endoscopy. The case for the ambulatory surgery center
    James T Frakes
    Department of Medicine, University of Illinois College of Medicine at Rockford, 1601 Parkview Avenue, Rockford, IL 61107, USA
    Gastrointest Endosc Clin N Am 12:215-27. 2002
    ..Although further questions and challenges are inevitable, EASCs can adapt quickly and deliver value. The author believes the future is deservedly bright for such facilities.
  100. doi Can transcranial brain-targeted bright light treatment via ear canals be effective in relieving symptoms in seasonal affective disorder? A pilot study
    Markku Timonen
    University of Oulu, Institute of Health Sciences General Practice, P O Box 5000, FIN 90014 Oulu, Finland
    Med Hypotheses 78:511-5. 2012
    b>Bright light therapy (BLT) is widely accepted as first-line treatment of seasonal affective disorder (SAD). However, the mechanism of action of BLT is still widely unknown...
  101. ncbi The bright minds beyond our machines: Henry Coandă and his ideas
    Ioan Mircea Coman
    Prof Dr C C Iliescu Institute of Cardiovascular Diseases, Bucharest, Romania
    J Cardiovasc Med (Hagerstown) 8:251-2. 2007
    ..Also, they almost ignore the bright minds beyond these ideas...

Research Grants69

  1. TREATMENT OF CIRCADIAN SLEEP DISORDERS WITH BRIGHT LIGHT
    Steven W Lockley; Fiscal Year: 2010
    ....
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..b>Bright lights will also be used so that the doctor can see the back of your eye. Photographs of the eye may be taken...
  3. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..b>Bright lights will also be used so that the doctor can see the back of your eye. Photographs of the eye may be taken...
  4. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  5. Circadian Rhythms and Sleep-Wake Cycles in Parkinson's Disease
    Aleksandar Videnovic; Fiscal Year: 2013
    ..of the project is to test the hypothesis that increasing the strength and stability of circadian rhythms, using bright light exposure, will improve sleep quality and daytime somnolence in PD...
  6. Sleep Length and Circadian Regulation in Humans
    HELEN JULIA BURGESS; Fiscal Year: 2012
    ..Circadian rhythm sleep disorders are effectively treated with bright light, which phase shifts the circadian clock, thereby realigning it with the timing of the external social world...
  7. Alternative Treatments for Premenstrual Dysphoric Disorder
    Barbara L Parry; Fiscal Year: 2013
    ..that advancing melatonin rhythms with late wake therapy (LWT: sleep 21:00-01:00 h, followed by wake) plus morning bright white light (BWL) will improve mood in PMDD patients more than delaying them with early wake therapy (EWT: wake, ..
  8. Complementary Chronotherapeutics for Pregnancy and Postpartum Depression
    Barbara L Parry; Fiscal Year: 2013
    ..hypothesize that early wake therapy (EWT: wake until 03:00 h, followed by sleep until 07:00 h) plus evening (PM) bright white light (BWL), which phase-delay melatonin rhythms, will improve mood more than late wake therapy (LWT: sleep ..
  9. The role of the circadian clock in encoding seasonal variations in day length
    JULIE SUZANNE PENDERGAST; Fiscal Year: 2010
    ..disorder (SAD) experience depressive episodes only during the fall and winter, and treatment with early morning bright light corrects the delay in their circadian rhythms...
  10. EXTRAOCULAR CIRCADIAN PHOTOTRANSDUCTION IN HUMANS
    Scott Campbell; Fiscal Year: 2001
    ..Timed exposure to bright light shows promise as an effective treatment for alleviation of such sleep and mood disorders which are thought ..
  11. Seasonality of Mood: A Genome-Wide Association Study in the Old Order Amish
    Teodor T Postolache; Fiscal Year: 2010
    ..increased appetite, weight and sleepiness, reduced energy and reproductive drive)24, the effectiveness of timed bright light exposure in treating SAD27-30, and an extended duration in winter of nocturnal melatonin secretion in SAD ..
  12. Treating sleep disruption in teens with millisecond light exposure during sleep
    Jamie M Zeitzer; Fiscal Year: 2013
    ..The loss of sleep in adolescence is pervasive and often debilitating for both the teen and the family. Bright light "phototherapy" is often prescribed for treatment of DSPD...
  13. Circadian Rhythm in Cone Photoreceptors: Cellular Mechanisms
    GLADYS Y KO; Fiscal Year: 2012
    ..Aim 1. Elucidate how miRNAs regulate the circadian rhythms of photoreceptor L-VGCCs. Aim 2. Investigate how bright light at night causes photoreceptor apoptosis more severely than during the day. Aim 3...
  14. CHRONOBIOLOGY OF PREMENSTRUAL SYNDROME
    Barbara Parry; Fiscal Year: 1993
    ..In Study II we will treat PMS patients with either morning bright light (which advances circadian rhythms), evening bright light (which delays circadian rhythms), or with evening ..
  15. Neuromodulators and Circadian Clocks: Roles in Retinal Function and Dysfunction
    P Michael Iuvone; Fiscal Year: 2013
    ..Dopamine (DA) is a circadian neuromodulator that optimizes retinal physiology for bright light, high-resolution vision during the daytime...
  16. Fluorophore-Conjugated Antibodies for Imaging and Resection of GI Tumors
    Meng Yang; Fiscal Year: 2013
    ..and absorption by overlying tissues and propensity for loss of fluorescence intensity with prolonged exposure to bright light, a phenomenon known as photobleaching...
  17. TREATMENTS FOR INSOMNIA
    Jerome Yesavage; Fiscal Year: 2003
    ..uses the principles of sleep hygiene (HYG) in addition to timed exposure to a placebo light, (2) HYG plus timed bright light exposure in the morning (HYG+AM LIGHT), and (3) HYG plus timed bright light exposure in the afternoon (HYG+..
  18. CLOCK RESETTING WITH EXTRAOCULAR LIGHT--DOSE RESPONSE
    HENRY SAVAGE; Fiscal Year: 1999
    ..Timed bright light exposure is a promising treatment for such sleep disorders that are thought to involve the biological clock...
  19. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  20. Using light to increase visual and perceptual cues and decrease falls risk
    MARIANA FIGUEIRO; Fiscal Year: 2010
    ..and to navigate safely through architectural spaces while minimizing sleep disruptions caused by turning on bright lights at night...
  21. Sensory Adapted Dental Environments to Enhance Oral Care for Children with Autism
    SHARON ANDREA CERMAK; Fiscal Year: 2012
    ..and negative behavioral reactions when confronted with experiential aspects of dental visits such as exposure to bright fluorescent lighting, touch in or around the mouth, or the texture and smell of various oral care products...
  22. Novel Nanorods for High Efficiency Medical Imaging Applications
    Christopher J Summers; Fiscal Year: 2011
    ..Although phosphor screens made from micron-sized phosphors are efficient, bright X-ray converters, their large particle size produces a great deal of scatter, which limits their spatial ..
  23. Melatonin in Menopausal Depression
    Barbara L Parry; Fiscal Year: 2012
    ..arousals in dim light at night, resulting in delayed wake time with decreased and delayed exposure to morning bright light, increased daytime sleep or insufficient or decreased sensitivity to light exposure, exacerbate the problem...
  24. Treatment of Circadian Disruption from Shiftwork in Older Adults
    Jeanne F Duffy; Fiscal Year: 2013
    ..We have shown previously that in young adults, bright light during the night shift can improve circadian adaptation to a night-work, day-sleep schedule, leading to ..
  25. Blue-White Light Therapy for Circadian Sleep Disorders in Alzheimer's Disease
    Philip Sloane; Fiscal Year: 2009
    ..always accompanied by marked disturbances of the circadian system, and research has established that controlled bright-dark light cycles will synchronize that system to the 24-hour solar day...
  26. MINIMIZING WORK SCHEDULE DISRUPTION WITH BRIGHT LIGHT
    Scott Campbell; Fiscal Year: 1993
    ..In contrast, the use of bright light offers a safe and viable alternative...
  27. Adolescent sleep delay: circadian regulation and phase shifting with light
    STEPHANIE CROWLEY MCWILLIAM; Fiscal Year: 2013
    ..b>Bright light is able to phase shift (reset) the circadian clock, and thus could help youngsters adjust to their early ..
  28. Enhanced Dynamic Range Proteomic Analysis: Phase II
    RAND SWANSON; Fiscal Year: 2011
    ..This system will record an initial image, then utilize a feedback loop to "turn off" the bright pixels and associated stray-light to more accurately measure regions within an image;(2) Demonstrate the NoRM in ..
  29. Enhanced Dynamic Range Proteomic Analysis: Phase II
    RAND SWANSON; Fiscal Year: 2013
    ..This system will record an initial image, then utilize a feedback loop to "turn off" the bright pixels and associated stray-light to more accurately measure regions within an image;(2) Demonstrate the NoRM in ..
  30. Pharmaceutical Therapy for Seasonal Affective Disorder
    Jay K Trautman; Fiscal Year: 2010
    ..Currently, there are no specific drug therapies for SAD. Patients are prescribed general anti-depressants or bright light therapy...
  31. Bright and Stable Near-IR dyes for Bioimaging
    ARUNKUMAR EASWARAN; Fiscal Year: 2009
    ..Our plan is to develop NIR absorbing bright and stable squaraine rotaxane dyes which can readily undergo conjugation with various biomolecules...
  32. High-Speed, Depth-Resolved Images of Cardiac physiology
    Guy Salama; Fiscal Year: 2007
    ..a) A system based on a Ronchi line grating to focus dark and bright bands in a focal plane 2-5 mm deep in ventricular tissue...
  33. Improved, Safer Alternatives to Semiconductor Quantum Dots
    Robert D Bolskar; Fiscal Year: 2010
    ..b>Bright emitting fluorophores are needed for newly emerging applications such as cellular and molecular imaging, and ..
  34. Light Treatment for Winter-SAD: Prediction of Response by Immediate Improvement
    TEODOR POSTOLACHE; Fiscal Year: 2009
    ..b>Bright light treatment has been shown to be safe and effective for SAD...
  35. Amnis ImageStream Analyzer for the Yale Flow Core
    Mark J Shlomchik; Fiscal Year: 2010
    ..There are six detection channels;two for bright and dark field, respect- timely and four for fluorescence...
  36. EXTRAOCULAR LIGHT TREATMENT
    HENRY SAVAGE; Fiscal Year: 2000
    ..The standard therapy for SAD, exposure to bright light for one half hour or more each morning during symptomatic episodes, is highly effective for most patients ..
  37. Bright, Photostable Surface Enhanced Fluorescent Nanotags
    Aaron Saunders; Fiscal Year: 2013
    ..The brightness and stability of the SEF nanotags will increase the sensitivity of detection of cancer surface markers leading to new and improved cancer diagnostics. ..
  38. Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth Nanoparticles
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2010
    ..Quantitative histology, using bright field microscopy on hematoxylin and eosin stained retinal sections, will be used to evaluate the morphological ..
  39. A fully validated assay to identify activators of ERSR in human glioma cells: ide
    Maurizio Grimaldi; Fiscal Year: 2012
    ..We screened the assay using automated compounds plating, manual cell dispensing and automated Bright Glow addition and reading, against the Prestwick II library (1120 FDA approved compounds + some natural molecules) ..
  40. Dynamics of Kinesins, Dyneins, and Myosins
    Paul R Selvin; Fiscal Year: 2010
    ..to see if the kinetics are similar;4) to measure the movement of melanosomes (which are non-fluorescent), using bright-Field Imaging with One Nanometer Accuracy (bFIONA), a knock-off of FIONA, and test the kinetics under various ..
  41. Biomarker Reference Laboratory, EDRN
    William E Grizzle; Fiscal Year: 2010
    ..tissue matrix arrays (spotted and tissue cylinders), computerized cytomorphometric analysis, immunohistochemistry (bright field fluorescent, confocal microscopy), in situ hybridization, single and multiplex real time quantitative PCR, ..
  42. AGE-RELATED ALTERATION OF LEYDIG CELL REDOX ENVIRONMENT A RISK FACTOR FOR SUSCEPT
    Kassim Traore; Fiscal Year: 2013
    ..Health (JHSPH) will be a significant step in establishing a broader collaboration between JHSPH and ECSU to bring bright young minority students to pursue further training in biomedical science at JHSPH...
  43. Generation of Site-Specific Recombinase-Expressing Transgenic Rats using an Enhan
    Eric M Ostertag; Fiscal Year: 2011
    ..Promoter traps will be visualized in live embryos and animals using bright fluorescent proteins (FPs)...
  44. Nuclear ryanodine receptor type 1: Role in skeletal muscle physiology and disease
    Viktor Yarotskyy; Fiscal Year: 2013
    ..2. Training Environment. Dr. Dirksen is fully committed to the complete training of outstanding and bright young scientists. Dr...
  45. Fragile X and Synaptic Plasticity
    Julie C Lauterborn; Fiscal Year: 2012
    ..and WT mice that constitutively express yellow fluorescent protein (YFP) in scattered pyramidal cells to provide a bright label of dendritic spines...
  46. A TRANSCRIPTION FACTOR WITHIN LIPID RAFTS MODULATES B CELL SIGNALING VIA THE BCR
    Philip W Tucker; Fiscal Year: 2010
    ..A growing body of evidence indicates that lipid rafts function as platforms for signalling through the BCR. Bright is a B cell-restricted transcription factor that transactivates the immunoglobulin heavy chain (IgH) locus by ..
  47. PHASE SHIFTING EFFECTS OF MELATONIN IN WINTER DEPRESSION
    Alfred Lewy; Fiscal Year: 2001
    ..We have found that human nighttime melatonin production is suppressed by bright light...
  48. Novel Fluorescent Nucleotide Analogues to Probe Nucleic Acid Metabolism
    BYRON WILLIS PURSE; Fiscal Year: 2010
    ..are available with colors in only a small range of the visible spectrum and they are an order of magnitude less bright than many common commercial fluors...
  49. Virtual reality system for cancer patients'shoulder pain and psychosocial impact
    Grigore C Burdea; Fiscal Year: 2012
    ..Data will be sampled transparently in real time during play and uploaded to Bright Cloud International Corp blade server;4) Usability study with 4 adult women without disability to uncover ..
  50. Testing in vivo of HIV-immunopathogenic hypotheses using new kinetic techniques
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2012
    ..Finally, the kinetic techniques will be applied to lymphoid tissue: establish egress vs death of CD62L-CD44 bright T-cells in mice (W...
  51. rAAV5-hCNGB3 Gene Therapy for Achromatopsia: Safety and Efficacy in a Dog Model
    Guo jie Ye; Fiscal Year: 2013
    ..achromatopsia experience extreme light sensitivity and daytime blindness, and best visual acuity under non-bright light conditions is usually 20/200 or worse and generally stable over time...
  52. Biotechnology Training in Biomedical Sciences and Engineering
    Yi Tang; Fiscal Year: 2013
    ..In sum, UCLA provides the talented multidisciplinary faculty, bright and diverse students, resources for research, courses, and opportunities to interact with industry that are ..
  53. Analysis of NGAL Metabolism Identifies a Therapy for Iron Overload
    Jonathan M Barasch; Fiscal Year: 2012
    ..complex occurred at subnanomolar affinity (Barasch, Nature Chemical Biology, 2010) forming a bright red protein, which was stable for many days in solution and stable in vivo for transport of its tightly bound iron...
  54. Arm Motor Rehabilitation, Entertainment and Cognition System for the Elderly
    Grigore C Burdea; Fiscal Year: 2010
    ..Data from the BC 100 will be sampled transparently in real time during play and uploaded to Bright Cloud International bladed servers...
  55. Bio-imaging with Isothermal DNA Self-Assembly
    David Yu Zhang; Fiscal Year: 2013
    ..For in situ whole embryo mRNA imaging, geometrically precise DNA nanostructures will act as bright optical "tags" specific to each mRNA target of interest...
  56. Bio-imaging with Isothermal DNA Self-Assembly
    David Yu Zhang; Fiscal Year: 2013
    ..For in situ whole embryo mRNA imaging, geometrically precise DNA nanostructures will act as bright optical "tags" specific to each mRNA target of interest...
  57. TRPA1: a polymodal sensor for aversive stimuli
    Craig Montell; Fiscal Year: 2013
    ..Aim 1 will test the hypothesis that bright light, which larvae avoid, activates TRPA1 through a novel mechanism of light detection that is independent of a ..
  58. Microscopy in the cochlea
    Mark J Schnitzer; Fiscal Year: 2011
    ..This will involve a novel 500-micron-diameter endoscope probe that can perform both bright-field and fluorescence imaging, as well as novel kinematic joints based on magnetic force and air bearings...
  59. Novel estrogen receptor ligands from plant genomics
    John M Littleton; Fiscal Year: 2012
    ..Now, any individual mutant in which the production of ER ligands is increased, should be identifiable by bright green fluorescence...
  60. Detection of Chromosomal Translocations by Single Molecule RNA Imaging
    Mona Batish; Fiscal Year: 2013
    ..This method enables each mRNA molecule to be seen as a bright, diffraction-limited spot in a fluorescence microscope...
  61. Trigeminal-autonomic relations in ocular homeostasis
    David A Bereiter; Fiscal Year: 2013
    ..To aid this effort, we developed a novel non-invasive stimulus paradigm that uses bright light...
  62. Engineering Microbial Rhodopsins as Optical Voltage Sensors
    ADAM EZRA COHEN; Fiscal Year: 2013
    ..When the cell fires an action potential, a proton is forced onto this functional group and the protein becomes bright. Just as GFP revolutionized biology through its ability to track the positions of proteins in cells, we believe ..
  63. The role of TLR9 on Aspergillus fumigatus phagosomes
    Jatin M Vyas; Fiscal Year: 2013
    ..phagosomes in macrophages results in a dramatic change of the subcellular distribution of TLR9 from the ER to a bright, ring-shaped compartment around the fungus 2) macrophages lacking Dectin-1 fail to recruit TLR9, indicating that ..
  64. Ultrasound-Induced Pulmonary Hemorrhage During Diagnostic Examination of the Lung
    DOUGLAS LAWRENCE MILLER; Fiscal Year: 2013
    ..6 MHz diagnostic ultrasound (DUS) showed the rapid development comet-tail artifacts across the bright lung surface image...
  65. Bright and Fast Sensor for Time Resolved X-Ray Diffraction Studies
    VIVEK V NAGARKAR; Fiscal Year: 2010
    ..develop the technology to grow microcolumnar films capable of providing an as-yet unattained combination of very bright signal, negligible afterglow, high spatial resolution (in excess of 20 lp/mm), and excellent temporal resolution, ..
  66. Bright and Fast Sensor for Time Resolved X-Ray Diffraction Studies
    Vivek Nagarkar; Fiscal Year: 2007
    ..Applications of a scintillator with very bright emission, high spatial resolution, high X-ray absorption efficiency, and rapid decay time with no afterglow range ..
  67. FUNCTION OF MATRIX ATTACHMENT REGIONS IN THE IG LOCI
    ANN FEENEY; Fiscal Year: 2000
    ..These MARs bind nuclear matrix preparations and also bind the regulatory proteins SATB1, Cux/CDP and Bright in EMSAs. Here, we will investigate the role of these V region promoter MARs...
  68. Effects of Massage on Immune System of Preterm Infants
    Jocelyn Ang; Fiscal Year: 2007
    ..Infants in the Neonatal Intensive Care Unit (NICU) are exposed to stressful stimuli such as loud noises, bright lights, blood drawing, suctioning and intubation, and are frequently left in isolates with minimal proper ..
  69. ULTRAFAST MULTIPHOTON LASER ACTIVATION SYSTEM
    WATT WEBB; Fiscal Year: 2001
    ..100 femtosecond) pulses generated by mode-locked lasers allow simultaneous absorption of two or more photons from bright pulsed illumination for molecular excitation as in the multiphoton laser scanning fluorescence microscopy used in ..