ARHGEF7

Summary

Gene Symbol: ARHGEF7
Description: Rho guanine nucleotide exchange factor 7
Alias: BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB, rho guanine nucleotide exchange factor 7, PAK-interacting exchange factor beta, Rho guanine nucleotide exchange factor (GEF) 7, SH3 domain-containing proline-rich protein
Species: human

Top Publications

  1. ncbi Salt-induced immobilizations of DNA oligonucleotides on an epoxide-activated high-performance liquid chromatographic affinity support
    J B Wheatley
    Terrapin Technologies, South San Francisco, CA 94080, USA
    J Chromatogr A 726:77-90. 1996
  2. pmc Differential activation of NF kappa B/RelA-p50 and NF kappa B/p50-p50 in control and alcohol-drinking rats subjected to carrageenin-induced pleurisy
    Ashok K Singh
    Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul Campus, St Paul, MN 55108, USA
    Mediators Inflamm 13:255-62. 2004
  3. doi A novel splice mutation in PAK3 gene underlying mental retardation with neuropsychiatric features
    Imen Rejeb
    Maladies Hereditaires et Congenitales, Service des Maladies Héréditaires et Congénitales, Hôpital Charles Nicole, Tunis, Tunisia
    Eur J Hum Genet 16:1358-63. 2008
  4. pmc Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation
    Jean Cheng Kuo
    Cell Biology and Physiology Centre, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    Nat Cell Biol 13:383-93. 2011
  5. ncbi The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors
    Richard T Premont
    Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Cell Signal 16:1001-11. 2004
  6. ncbi A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins
    S Bagrodia
    Department of Molecular Medicine, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853 6401, USA
    J Biol Chem 274:22393-400. 1999
  7. pmc Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome
    Satu Kärkkäinen
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 8, Tampere 33014, Finland
    EMBO Rep 7:186-91. 2006
  8. doi Direct GSK-3β inhibition enhances mesenchymal stromal cell migration by increasing expression of β-PIX and CXCR4
    Young Seo Kim
    Department of Neurology, College of Medicine, Hanyang University, 249 1 Gyomun dong, Guri si, Seoul, Gyeonggi do 471 701, Republic of Korea
    Mol Neurobiol 47:811-20. 2013
  9. ncbi Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion
    W K Oh
    Department of Life Science, Kwang Ju Institute of Science and Technology, Korea
    Biochem Biophys Res Commun 235:794-8. 1997
  10. ncbi Mammalian Scribble forms a tight complex with the betaPIX exchange factor
    Stéphane Audebert
    Molecular Pharmacology, Institut de Recherches sur le Cancer de Marseille, Unite mixte de recherche 599 Inserm Institut Paoli Calmettes, 27 Boulevard Lei Roure, 13009 Marseille, France
    Curr Biol 14:987-95. 2004

Research Grants

Detail Information

Publications340 found, 100 shown here

  1. ncbi Salt-induced immobilizations of DNA oligonucleotides on an epoxide-activated high-performance liquid chromatographic affinity support
    J B Wheatley
    Terrapin Technologies, South San Francisco, CA 94080, USA
    J Chromatogr A 726:77-90. 1996
    ..Purified p50 protein, the DNA binding element of NF-kappa B, and nuclear extracts from phorbol ester-stimulated HeLa cells were ..
  2. pmc Differential activation of NF kappa B/RelA-p50 and NF kappa B/p50-p50 in control and alcohol-drinking rats subjected to carrageenin-induced pleurisy
    Ashok K Singh
    Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul Campus, St Paul, MN 55108, USA
    Mediators Inflamm 13:255-62. 2004
    ..Inflammation onset is characterized by an activation of pro-inflammatory NFkappaB, RelA-p50, while inflammation resolution is characterized by an activation of an anti-inflammatory NFkappaB, p50-p50, that re-..
  3. doi A novel splice mutation in PAK3 gene underlying mental retardation with neuropsychiatric features
    Imen Rejeb
    Maladies Hereditaires et Congenitales, Service des Maladies Héréditaires et Congénitales, Hôpital Charles Nicole, Tunis, Tunisia
    Eur J Hum Genet 16:1358-63. 2008
    b>PAK3-related mental retardation represents a rare cause of X-linked mental retardation associated with behavioural symptoms...
  4. pmc Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation
    Jean Cheng Kuo
    Cell Biology and Physiology Centre, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    Nat Cell Biol 13:383-93. 2011
    ....
  5. ncbi The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors
    Richard T Premont
    Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Cell Signal 16:1001-11. 2004
    ..Thus, GIT and PIX proteins are tightly associated as a multimeric nexus capable of linking together important signaling molecules, including PAKs...
  6. ncbi A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins
    S Bagrodia
    Department of Molecular Medicine, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853 6401, USA
    J Biol Chem 274:22393-400. 1999
    ..We, and others, recently identified a family of proteins termed Cool/Pix, which interact with Pak3. In cells, p50(Cool-1) suppresses Pak activation by upstream activators; p85(Cool-1) has a permissive effect on Pak ..
  7. pmc Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome
    Satu Kärkkäinen
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 8, Tampere 33014, Finland
    EMBO Rep 7:186-91. 2006
    ....
  8. doi Direct GSK-3β inhibition enhances mesenchymal stromal cell migration by increasing expression of β-PIX and CXCR4
    Young Seo Kim
    Department of Neurology, College of Medicine, Hanyang University, 249 1 Gyomun dong, Guri si, Seoul, Gyeonggi do 471 701, Republic of Korea
    Mol Neurobiol 47:811-20. 2013
    ..Enhancing the migration capacity of hBM-MSCs by treating these cells with GSK-3β inhibitors may increase their therapeutic potential...
  9. ncbi Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion
    W K Oh
    Department of Life Science, Kwang Ju Institute of Science and Technology, Korea
    Biochem Biophys Res Commun 235:794-8. 1997
    ..In A431 cell, p85SPR is enriched at focal adhesion points indicating that the protein may interact with protein(s) in focal complexes.
  10. ncbi Mammalian Scribble forms a tight complex with the betaPIX exchange factor
    Stéphane Audebert
    Molecular Pharmacology, Institut de Recherches sur le Cancer de Marseille, Unite mixte de recherche 599 Inserm Institut Paoli Calmettes, 27 Boulevard Lei Roure, 13009 Marseille, France
    Curr Biol 14:987-95. 2004
    ..These data reveal the existence of a tight hScrib/betaPIX interaction and suggest that this complex potentially plays a role in neuronal transmission...
  11. pmc Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling
    C E Turner
    Department of Anatomy and Cell Biology, State University of New York, Health Science Center, Syracuse, New York 13210, USA
    J Cell Biol 145:851-63. 1999
    ..These data implicate paxillin as a mediator of p21 GTPase-regulated actin cytoskeletal reorganization through the recruitment to nascent focal adhesion structures of an active PAK/PIX complex potentially via interactions with p95PKL...
  12. ncbi Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth
    Qiyu Feng
    Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
    Nat Cell Biol 8:945-56. 2006
    ..These findings demonstrate that the regulated phosphorylation of Cool-1 is necessary to maintain the balance between normal signalling by EGFR and Src versus aberrant growth and transformation...
  13. ncbi The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo
    Seho Kim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 278:6291-300. 2003
    ..These results suggest that, through their multimerization and interaction with Piccolo, the GIT family proteins are involved in the organization of the CAZ...
  14. ncbi The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing
    R T Premont
    Departments of Medicine and Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 275:22373-80. 2000
    ..Although GIT2 shares many properties with GIT1, it also exhibits both structural and functional diversity due to tissue-specific alternative splicing...
  15. ncbi PAK kinases are directly coupled to the PIX family of nucleotide exchange factors
    E Manser
    Glaxo IMCB Group, Institute of Molecular and Cell Biology, Singapore
    Mol Cell 1:183-92. 1998
    ..PIX can induce membrane ruffling, with an associated activation of Rac1. Our results suggest a role for PIX in Cdc42-to-Rac1 signaling, involving the PIX/PAK complex...
  16. pmc Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix
    Jean Paul ten Klooster
    Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, Netherlands
    J Cell Biol 172:759-69. 2006
    ..These data provide a model for the intracellular targeting and localized activation of Rac1 through its exchange factor beta-Pix...
  17. ncbi Basic fibroblast growth factor stimulates activation of Rac1 through a p85 betaPIX phosphorylation-dependent pathway
    Eun Young Shin
    Department of Biochemistry, College of Medicine, Medical Research Institute and Biotechnology Research Institute, College of Natural Sciences, Chungbuk National University, San 48, Gaesin dong, Heungduk Ku, Cheongju 361 763, Korea
    J Biol Chem 279:1994-2004. 2004
    ..Bokoch, G. M., and Kim, E. G. (2002) J. Biol. Chem. 277, 44417-44430) we reported that phosphorylation of p85 betaPIX, a guanine nucleotide exchange factor (GEF) for Rac1/Cdc42, is a signal for translocation of the PIX ..
  18. pmc Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway
    Michael C Brown
    Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse 13210, USA
    Mol Biol Cell 13:1550-65. 2002
    ..This mechanism is probably critical for the correct subcellular positioning of PAK, thereby influencing the ability of PAK to coordinate cytoskeletal reorganization associated with changes in cell shape and motility...
  19. ncbi A novel regulator of p21-activated kinases
    S Bagrodia
    Department of Molecular Medicine, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853 6401, USA
    J Biol Chem 273:23633-6. 1998
    ..Here we report the identification of two closely related Pak3-binding proteins, possibly arising from alternative splicing, designated p50 and p85(Cool-1) (cloned out of library)..
  20. ncbi Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation
    Wen Jin Wu
    Department of Molecular Medicine, Veterinary Medical Center, Baker Laboratory, Cornell University, Ithaca, NY 14853, USA
    Cell 114:715-25. 2003
    ....
  21. ncbi Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK)
    Helen R Mott
    Department of Biochemistry, University of Cambridge, UK
    Biochemistry 44:10977-83. 2005
    ..When PAK is activated, Ser-199 in the PIX-binding site is phosphorylated. This phosphorylation is sufficient to reduce the affinity for PIX 6-fold...
  22. pmc Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding
    Ahmed Chahdi
    Division of Nephrology and Kidney Disease Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Mol Cell Biol 28:1679-87. 2008
    ..These results indicate that 14-3-3beta negatively affects the GEF activity of dimeric beta(1)Pix only. Altogether, these results provide a mechanistic insight into the role of 14-3-3beta in modulating beta(1)Pix-GEF activity...
  23. pmc BetaPix up-regulates Na+/H+ exchanger 3 through a Shank2-mediated protein-protein interaction
    Jung Soo Lee
    Department of Pharmacology and Brain Korea 21 Project for Medical Science, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 120 752, Korea
    J Biol Chem 285:8104-13. 2010
    ..These results indicate that betaPix up-regulates NHE3 membrane expression and activity by Shank2-mediated protein-protein interaction and by activating Rho GTPases in the apical regions of epithelial cells...
  24. ncbi Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion
    Chol Seung Lim
    Department of Life Science, Kwangju Institute of Science and Technology, 1 Oryong dong, Buk Gu, Gwangju 500 712, Korea
    J Biol Chem 278:52116-23. 2003
    ..It thus appears that the interaction of the betaPIX.WASP.SPIN90 complex with Nck is crucial for stable cell adhesion and can be dynamically modulated by SPIN90 phosphorylation that is dependent on cell adhesion and ERK activation...
  25. ncbi Involvement of Raf-1 kinase and protein kinase C zeta in insulin-like growth factor I-induced brown adipocyte mitogenic signaling cascades: inhibition by cyclic adenosine 3',5'-monophosphate
    A M Valverde
    , Facultad de Farmacia, Universidad Complutense, Madrid, Spain
    Endocrinology 137:3832-41. 1996
    ..5-fold, whereas the tyrosine-phosphorylated IGF-I receptor was not directly associated with the p85 subunit of the phosphatidylinositol 3-kinase...
  26. pmc A three-dimensional collagen lattice induces protein kinase C-zeta activity: role in alpha2 integrin and collagenase mRNA expression
    J Xu
    Department of Dermatology, School of Medicine, SUNY at Stony Brook, New York 11794-8165, USA
    J Cell Biol 136:473-83. 1997
    ..The composition of the NF-kappaB/Rel complexes that contained p50, was not changed...
  27. ncbi Effect of a synthetic lipid immunomodulator on the regulation of the transcription factor NF-kappaB
    S Pollet
    , La Tronche, France
    Immunopharmacol Immunotoxicol 22:653-69. 2000
    ..Antibodies to various NF-kappaB proteins supershifted p50, p65 and to a lesser extent c-rel...
  28. ncbi Ca(2+)-evoked serotonin secretion by parafollicular cells: roles in signal transduction of phosphatidylinositol 3'-kinase, and the gamma and zeta isoforms of protein kinase C
    K Liu
    Division of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 20:1365-73. 2000
    ..PF cells were found to express regulatory (p85) and catalytic (p110alpha and p110beta) subunits of phosphatidylinositol 3'-kinase (PI3'-kinase)...
  29. pmc Automated oxyhemoglobin dissociation curve construction to assess sickle cell anemia therapy
    R C Young
    School of Medicine, Meharry Medical College, Nashville, TN 37208, USA
    J Natl Med Assoc 92:430-5. 2000
    ..Oxygen affinity of red cells was assessed by calculation of P50 (the PO2 at which hemoglobin is half saturated)...
  30. ncbi Coupling of M2 muscarinic receptors to membrane ion channels via phosphoinositide 3-kinase gamma and atypical protein kinase C
    Y X Wang
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 274:13859-64. 1999
    ..PI-3K and by injection of beta gamma binding peptides, but it was not affected by expression of dominant negative p85 cRNA...
  31. ncbi Oxygen transport dynamics of acellular hemoglobin solutions in an isovolemic hemodilution model in swine
    S N Vaslef
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Trauma 51:1153-60. 2001
    ..We hypothesized that acellular hemoglobin solutions are useful oxygen carriers in anemic states and that higher P50 solutions transport O2 more efficiently than low P50 solutions...
  32. ncbi Paraspinal muscle evoked cerebral potentials in patients with unilateral low back pain
    Y Zhu
    Department of Neurology, University of California, Irvine
    Spine (Phila Pa 1976) 18:1096-102. 1993
    ..In patients with unilateral muscle spasm, the amplitudes of P30-N40, N40-P50, and P50-N70 were decreased significantly on the affected side when compared with values on stimulation of the ..
  33. ncbi [Pattern electroretinogram in anterior ischemic optic neuropathy]
    C Almarcegui
    Servicio de Neurofisiologia Clinica, Hospital Miguel Servet, Zaragoza, Espana
    Rev Neurol 32:18-21. 2001
    ..Anterior ischemia optic neuropathy is defined as ischemia of the disc optic papilla nerve. The aetiology is multifactorial and causes ischemia of the optic disc and apoptosis of the nerve cells of the retina...
  34. ncbi Inhibition of NF-kappaB-DNA binding by mercuric ion: utility of the non-thiol reductant, tris(2-carboxyethyl)phosphine hydrochloride (TCEP), on detection of impaired NF-kappaB-DNA binding by thiol-directed agents
    F J Dieguez-Acuna
    Department of Environmental Health, 4225 Roosevelt Way NE, Suite 100, University of Washington, Seattle, WA 98105, USA
    Toxicol In Vitro 14:7-16. 2000
    ..of nuclear factor kappaB (NF-kappaB) by mercaptide bond formation with a critical cysteine moiety (cys(62)) on the p50 subunit required for DNA binding...
  35. ncbi NF-kappaB involvement in the activation of primary adult T-cell leukemia cells and its clinical implications
    N Arima
    First Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Sakuragaoka, Japan
    Exp Hematol 27:1168-75. 1999
    ..activities in human T cells are mediated by at least four c-Rel-related DNA binding proteins - p50, p55, p75 and p85. We examined the significance of NF-kappaB induction in primary adult T cell leukemia cells and the induction ..
  36. ncbi [The efficacy of autocatalytic casapse-3 driven by human telomerase reverse transcriptase promoter on human ovarian carcinoma]
    Yue Song
    Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
    Zhonghua Yi Xue Za Zhi 87:2919-24. 2007
    ..To construct recombinant adenoviral vector expressing autocatalysis caspase-3 driven by human telomerase reverse transcriptase promoter (hTERTp), and investigate its antitumor effect on ovarian cancer in vitro and in vivo...
  37. ncbi Granulocyte-macrophage colony-stimulating factor signals for increased glucose transport via phosphatidylinositol 3-kinase- and hydrogen peroxide-dependent mechanisms
    Manya Dhar-Mascareno
    Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 278:11107-14. 2003
    ..motif in alpha GMR at residues 358-361 as a potential interaction site for the PI 3-kinase regulatory subunit, p85. Physical evidence for p85 binding to alpha GMR was obtained by co-immunoprecipitation with antibodies to alpha GMR ..
  38. doi Pentoxifylline treatment improves neurological and neurochemical deficits in rats subjected to transient brain ischemia
    Renata de Barros Bruno
    Department of Biophysiology and Pharmacology, Faculty of Medicine of Juazeiro do Norte FMJ, Av Tenente Raimundo Rocha s n, Juazeiro do Norte, 63040 000, Brazil
    Brain Res 1260:55-64. 2009
    ..This parameter was not significantly reversed after P treatment (ISC+P50 or ISC+P100)...
  39. pmc NF-kappa B p50 regulates C/EBP alpha expression and inflammatory cytokine-induced neutrophil production
    Dehua Wang
    Division of Pediatric Oncology, Johns Hopkins University, Baltimore, MD 21231, USA
    J Immunol 182:5757-62. 2009
    ..Having found that C/EBPalpha binds NF-kappaB p50 preferentially compared with NF-kappaB p65, we have now investigated myelopoiesis in nfkb1(-/-) mice lacking NF-..
  40. ncbi Cardiorespiratory responses of the woodchuck and porcupine to CO2 and hypoxia
    D F Boggs
    Department of Zoology, University of Montana, Missoula 59812
    J Comp Physiol B 159:641-8. 1989
    ..The woodchuck P50 of 27.8 was hardly different from the porcupine value of 30.7, but the Bohr factor, -0...
  41. pmc Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells
    A Moretta
    Istiuto Nazionale per la Ricerca sul Cancro, Genova Italy
    J Exp Med 182:875-84. 1995
    ..Biochemical analysis of the activatory EB6 molecules revealed a molecular mass of approximately 50 kD (p50), thus differing from the 58-kD inhibitory form...
  42. ncbi NF-kappaB regulates the expression of the human complement receptor 2 gene
    Mate Tolnay
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Immunol 169:6236-43. 2002
    ..By supershift analysis, the first two elements bound NF-kappaB p50 and p65 and heterogeneous nuclear ribonucleoprotein RNP D, respectively...
  43. ncbi The use of visual evoked potentials to follow-up prisoners of war after release from detention camps
    A Vrca
    Department of Neurology, Clinical Hospital Dubrava, Zagreb, Croatia
    Coll Antropol 21:229-33. 1997
    ..statistically significantly prolonged latencies of the P100 wave and significantly greater amplitudes of waves P50 and N75. The results can be regarded as progression of the VEP changes in the released POWs...
  44. ncbi Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells
    H Serve
    Molecular Biology Program, Sloan Kettering Institute, New York, New York
    J Biol Chem 269:6026-30. 1994
    ..of the immediate events after binding of the kit ligand to the receptor is its association with the 85-kDa subunit (p85) of the phosphatidylinositol (PI) 3-kinase and the activation of the enzyme...
  45. ncbi Enhancement of nuclear factor-kappa B acetylation by coactivator p300 and HIV-1 Tat proteins
    Bansri Furia
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    J Biol Chem 277:4973-80. 2002
    ..Here, we show that the p50 subunit as well as the p50/p65 of NF-kappaB, and not other factors such as SP1, TFIIB, polymerase II, TFIIA, or p65,..
  46. ncbi A comparative study of the phosphotyrosyl phosphatase specificity of protein phosphatase type 2A and phosphotyrosyl phosphatase type 1B using phosphopeptides and the phosphoproteins p50/HS1, c-Fgr and Lyn
    P Agostinis
    Afdeling Biochemie, Faculteit der Geneeskunde, Katholieke Universiteit Leuven, Belgium
    Eur J Biochem 236:548-57. 1996
    ..examined in vitro using phosphotyrosine-containing peptides, derived from the phosphorylation sites of p34cdc2, p50/HS1 protein, Abl, c-Src and c-Fgr, as well as the intact phosphoprotein p50/HS1 and the Src-related tyrosine ..
  47. ncbi Recruitment of the tyrosine phosphatase Src homology 2 domain tyrosine phosphatase-2 to the p85 subunit of phosphatidylinositol-3 (PI-3) kinase is required for insulin-like growth factor-I-dependent PI-3 kinase activation in smooth muscle cells
    Mijin Kwon
    Division of Endocrinology, 6111 Thurston Bowles, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7170, USA
    Endocrinology 147:1458-65. 2006
    ..Similarly in cells expressing native SHP-2, IGF-I induced SHP-2 binding to p85, whereas in cells expressing SHP-2/C459S, there was no increase...
  48. ncbi Clinical ability of pattern electroretinograms and visual evoked potentials in detecting visual dysfunction in ocular hypertension and glaucoma
    Vincenzo Parisi
    Fondazione per l Oftalmologia G B Bietti IRCCS, Rome, Italy
    Ophthalmology 113:216-28. 2006
    ..To assess the presence of normal or abnormal pattern electroretinogram (PERG) and visual evoked potential (VEP) responses in patients with ocular hypertension or open-angle glaucoma (OAG)...
  49. pmc Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation
    C Kunsch
    Department of Gene Regulation, Roche Institute of Molecular Biology, Nutley, New Jersey 07110
    Mol Cell Biol 12:4412-21. 1992
    Analysis of the p50 and p65 subunits of the NF-kappa B transcription factor complex has revealed that both proteins can interact with related DNA sequences through either homo- or heterodimer formation...
  50. ncbi [The paradigm of abnormal sensory gating in fear extinction as pathophysiology in obsessive-compulsive disorder]
    Eiji Shimizu
    Department of Cognitive Behavioral Physiology, Chiba University Graduate School of Medicine
    Seishin Shinkeigaku Zasshi 113:54-9. 2011
    ..We have reported alterations of auditory P50 suppression in human fear conditioning and extinction in healthy control subjects (Kurayama, et al., 2009)...
  51. ncbi Beta-adrenergic control of blood oxygen affinity in acutely hypoxia exposed rainbow trout
    V Tetens
    Department of Zoophysiology, University of Aarhus, Denmark
    J Comp Physiol B 157:667-75. 1987
    ..01) increase in blood O2 affinity, from the normoxic P50 value (at pHc 7.93) of 23.2 +/- 1.1 mmHg to about 19 mmHg, within 5 min...
  52. ncbi [Estrogen protects the dopaminergic neurons in substantia nigra against damage induced by 6-hydroxydopamine]
    Jin Lan Meng
    Department of Physiology, Kunming Medical University, Kunming 650031, China
    Sheng Li Xue Bao 60:369-74. 2008
    Substantial evidence strongly implies that sensory gating P50 (also called P50 auditory evoked potential, P50) and dopaminergic neurotransmitters are related...
  53. ncbi Role of protein phosphatase 2A in calcium-dependent chloride secretion by human colonic epithelial cells
    Jimmy Y C Chow
    Division of Gastroenterology, 0063 University Center 303, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0063, USA
    Am J Physiol Cell Physiol 292:C452-9. 2007
    ..Although both EGF and carbachol cause tyrosine phosphorylation of p85 of PI 3-kinase, only EGF activates the enzyme...
  54. ncbi A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation
    C Bottino
    Istituto Scientifico Tumori, Genova, Italy
    Eur J Immunol 26:1816-24. 1996
    Human natural killer (NK) cells express inhibitory (p58) or activatory (p50) receptors for HLA-C alleles. Here, we describe a novel member of the p58/p50 family that is expressed by a subset of NK cells in about one third of donors...
  55. pmc Reduced basal and lipopolysaccharide-stimulated adenosine A1 receptor expression in the brain of nuclear factor-kappaB p50-/- mice
    K A Jhaveri
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794 9629, USA
    Neuroscience 146:415-26. 2007
    ..The prototypic transcription factor is composed of homo- or heterodimers of p50 and p65 subunits...
  56. pmc Effect of pluronic p85 on amino acid transport in bovine brain microvessel endothelial cells
    XiaoBin Zhang
    Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Neuroimmune Pharmacol 4:35-46. 2009
    A synthetic amphiphilic block copolymer Pluronic P85 (P85) was shown to be among the most potent inhibitors of Pgp efflux system in the blood-brain barrier (BBB) and capable of enhancing delivery of Pgp substrates to the brain...
  57. ncbi Two major proteins from locust plasma are involved in coagulation and are specifically precipitated by laminarin, a beta-1,3-glucan
    B Duvic
    Laboratoire de Pathologie Comparée, URA INRA CNRS 2209, Universite de Montpellier II, France
    Insect Biochem Mol Biol 28:959-67. 1998
    ..induced the precipitation of two major proteins with molecular masses of about 260,000 (P260) and 85,000 Da (P85)...
  58. pmc Independence of stem and leaf hydraulic traits in six Euphorbiaceae tree species with contrasting leaf phenology
    Jun Wen Chen
    Kunming Division, Xishuangbanna Tropical Botanical Garden, The Chinese Academy of Sciences, 88 Xuefu Road, 650223, Kunming, Yunnan, People s Republic of China
    Planta 230:459-68. 2009
    ..Xylem water potential at 50% loss of stem hydraulic conductivity (P50(stem)) was more negative in the evergreen tree, but leaf water potential at 50% loss of leaf hydraulic conductivity ..
  59. ncbi Mechanisms of ubiquitin-mediated, limited processing of the NF-kappaB1 precursor protein p105
    A Ciechanover
    Department of Biochemistry and the Rappaport Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Biochimie 83:341-9. 2001
    ..NF-kappaB, the substrate, the precursor protein p105, is processed in a limited manner to yield the active subunit p50. p50 is derived from the N-terminal domain of p105, whereas the C-terminal domain is degraded...
  60. ncbi Missense mutation in PAK3, R67C, causes X-linked nonspecific mental retardation
    T Bienvenu
    Institut National de la Santé et de la Recherche Médicale U129 ICGM, Faculté de Médecine Cochin, Paris, France
    Am J Med Genet 93:294-8. 2000
    ..Recently, a study using the candidate gene approach demonstrated the presence of mutations in PAK3 (p21-activating kinase) associated with nonspecific mental retardation...
  61. pmc Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappa B in mice
    Howard P Glauert
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40506, USA
    Toxicol Appl Pharmacol 232:302-8. 2008
    ..The present study examined the effect of deleting the p50 subunit of NF-kappaB on the hepatic tumor promoting activity of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) in mice...
  62. pmc Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase
    C Guinebault
    Institut National de la Sante et de la Recherche Medicale, Unité 326, Hopital Purpan, Toulouse, France
    J Cell Biol 129:831-42. 1995
    ..but not of PtdIns(3,4,5,)P3 is strongly correlated with the relocation to the cytoskeleton of 29% of the p85 alpha regulatory subunit of phosphoinositide 3-kinase (PtdIns 3-kinase) and is accompanied by a significant ..
  63. pmc Overexpression in COS cells of p50, the major core protein associated with mRNA, results in translation inhibition
    E K Davydova
    Department of Biological Chemistry, School of Medicine, University of California, Davis, CA 95616, USA
    Nucleic Acids Res 25:2911-6. 1997
    b>p50, the major core protein of messenger ribonucleoprotein particles (mRNPs) in the cytoplasm of somatic mammalian cells, has been characterized previously as a member of the Y-box binding transcription factor family of proteins (YB-..
  64. pmc Targeted deletion of NF-kappaB p50 diminishes the cardioprotection of histone deacetylase inhibition
    L X Zhang
    Department of Medicine, Brown Medical School, Brown University, Providence, Rhode Island, USA
    Am J Physiol Heart Circ Physiol 298:H2154-63. 2010
    ..The purpose of this study is to investigate whether the disruption of NF-kappaB p50 would eliminate the protective effects of HDAC inhibition...
  65. ncbi [Sensory gating P50 in schizophrenic patients with and without homicide]
    Hong Xing Wang
    Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
    Zhonghua Yi Xue Za Zhi 89:2616-20. 2009
    To investigate the change of sensory gating P50 in schizophrenic patients with and without homicide.
  66. ncbi Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B
    Michal F Tomczak
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 177:7332-9. 2006
    Defects within the innate immune system sensitize NF-kappaB-deficient (p50(-/-); p65(+/-)) mice to Helicobacter hepaticus (Hh)-induced colitis...
  67. ncbi Ebselen, a seleno-organic antioxidant, is neuroprotective after embolic strokes in rabbits: synergism with low-dose tissue plasminogen activator
    Paul A Lapchak
    University of California San Diego, Department of Neuroscience, MTF 316, 9500 Gilman Dr, La Jolla, Calif 92093 0624, USA
    Stroke 34:2013-8. 2003
    ..Therefore, we determined the effects of ebselen when administered alone or with the thrombolytic tissue plasminogen activator (tPA), the only Food and Drug Administration-approved pharmacological agent for the treatment of stroke...
  68. pmc A novel RBP-J kappa-dependent switch from C/EBP beta to C/EBP zeta at the C/EBP binding site on the C-reactive protein promoter
    Prem Prakash Singh
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Immunol 178:7302-9. 2007
    ..A critical transcriptional regulatory element on the CRP promoter is a C/EBP binding site overlapping a NF-kappaB p50 binding site. In response to IL-6, C/EBPbeta and p50 occupy the C/EBP-p50 site on the CRP promoter...
  69. ncbi [Expression of phosphatidylinositol-3 kinase in epithelial ovarian carcinoma]
    Peng Nan Zhang
    Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China
    Zhonghua Fu Chan Ke Za Zhi 42:196-200. 2007
    ....
  70. ncbi Pharmacology of caffeinol in embolized rabbits: clinical rating scores and intracerebral hemorrhage incidence
    Paul A Lapchak
    University of California San Diego, Department of Neuroscience, La Jolla 92093 0624, USA
    Exp Neurol 188:286-91. 2004
    ..analysis was conducted 24 h following embolization, allowing for the determination of the effective stroke dose (P50) or clot amount (mg) that produces neurological deficits in 50% of the rabbits...
  71. pmc The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner
    G P Nolan
    Rockefeller University, New York, New York 10021
    Mol Cell Biol 13:3557-66. 1993
    ..In vitro, Bcl-3 protein specifically inhibited the DNA binding of both the homodimeric NF-kappa B p50 subunit and a closely related homolog, p52 (previously p49), to immunoglobulin kappa NF-kappa B DNA motifs...
  72. ncbi Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity
    J E Damen
    Terry Fox Laboratory, British Columbia Cancer Research Centre, Vancouver, Canada
    J Biol Chem 270:23402-8. 1995
    ..with the activated erythropoietin receptor (EpR), most likely through the Src homology 2 (SH2) domains within the p85 subunit of PI-3 kinase and one or more phosphorylated tyrosines within the EpR...
  73. ncbi Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego 92093 0804, USA
    Am J Psychiatry 157:55-9. 2000
    ..Attention and information processing can be assessed by testing suppression of the P50 event-related potential; the amplitude of the P50 wave is measured in response to each of two auditory clicks...
  74. ncbi The smaller isoforms of ankyrin 3 bind to the p85 subunit of phosphatidylinositol 3'-kinase and enhance platelet-derived growth factor receptor down-regulation
    Ashley Ignatiuk
    Cancer Research Unit, Health Research Division, Saskatchewan Cancer Agency, 20 Campus Drive, Saskatoon, Saskatchewan S7N 4H4, Canada
    J Biol Chem 281:5956-64. 2006
    The Src homology 2 (SH2) domains of the p85 subunit of phosphatidylinositol 3'-kinase have been shown to bind to the tyrosine-phosphorylated platelet-derived growth factor receptor (PDGFR)...
  75. ncbi Reestimation of the effects of inorganic phosphates on the equilibrium between oxygen and hemoglobin
    T Clerbaux
    Department of Internal Medicine, Cliniques Universitaries St Luc, Brussels, Belgium
    Intensive Care Med 18:222-5. 1992
    ..data obtained in patients with severe ketoacidosis suggest that inorganic phosphates (K2HPO4) can increase their P50 and therefore enhance tissue oxygenation without concomitant alteration of the 2,3 diphosphoglycerate (DPG)...
  76. ncbi p68 Sam is a substrate of the insulin receptor and associates with the SH2 domains of p85 PI3K
    V Sanchez-Margalet
    Department of Medical Biochemistry and Molecular Biology, School of Medicine, University of Seville, University Hospital Virgen Macarena, Spain
    FEBS Lett 455:307-10. 1999
    ..insulin receptor and fusion proteins containing either the N-terminal or the C-terminal Src homology 2 domain of p85 phosphatidylinositol-3-kinase...
  77. doi P85, Optison microbubbles and ultrasound cooperate in mediating plasmid DNA transfection in mouse skeletal muscles in vivo
    Yun Chao Chen
    Ultrasound Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Ultrason Sonochem 18:513-9. 2011
    ..In the present study, we explored if the combination of P85, a pluronic block copolymer, Optison, a microbubble contrast agent and ultrasound enhances the transfection of ..
  78. ncbi Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation
    Robert Kleemann
    Gaubius Laboratory Nederlandse Organisatie voor toegepast natuurwetenschappelijk onderzoek TNO Prevention and Health, Leiden, The Netherlands
    Blood 101:545-51. 2003
    ..2 overlapping response elements, the binding sites for CCAAT-box/enhancer-binding protein-beta (C/EBP-beta) and p50-nuclear factor-kappaB (p50-NFkappaB)...
  79. ncbi Interaction of the insulin receptor beta-subunit with phosphatidylinositol 3-kinase in bovine ROS
    R V Rajala
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, 608 Stanton L Young Boulevard, Oklahoma City, OK 73104, USA
    Invest Ophthalmol Vis Sci 42:3110-7. 2001
    ..To identify the tyrosine-phosphorylated protein(s) in bovine rod outer segments (ROS) that are associated with phosphatidylinositol 3-kinase (PI3K)...
  80. ncbi Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells
    P Kaliman
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    Mol Endocrinol 12:66-77. 1998
    ..involvement of PI 3-kinase in IGF-induced myogenesis by overexpressing in L6E9 myoblasts a dominant negative p85 PI 3-kinase-regulatory subunit (L6E9-delta p85)...
  81. pmc Rapid induction in regenerating liver of RL/IF-1 (an I kappa B that inhibits NF-kappa B, RelB-p50, and c-Rel-p50) and PHF, a novel kappa B site-binding complex
    M Tewari
    Department of Human Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104 6145
    Mol Cell Biol 12:2898-908. 1992
    ..RL/IF-1 has I kappa B activity of broad specificity in that it inhibits the binding of p50-p65 NF-kappa B, c-Rel-p50, and RelB-p50, but not p50 homodimeric NF-kappa B, to kappa B sites...
  82. pmc Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues
    James C Lo
    Committee on Immunology and Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Blood 107:1048-55. 2006
    ..We now demonstrate that p105/p50 also constitutes an important pathway for LTbetaR signaling...
  83. ncbi Interaction of the retinal insulin receptor beta-subunit with the p85 subunit of phosphoinositide 3-kinase
    Raju V S Rajala
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Biochemistry 43:5637-50. 2004
    ..of protein-protein interaction in the yeast Saccharomyces cerevisiae to demonstrate the interaction between the p85 subunit of PI3K and the cytoplasmic region of IRbeta...
  84. ncbi Kappa B-specific DNA binding proteins are differentially inhibited by enhancer mutations and biological oxidation
    J A Molitor
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, NC 27710
    New Biol 3:987-96. 1991
    ..These two DNA-protein complexes are composed of at least four host proteins (p50, p55, p75, p85), each of which shares structural similarity with the v-rel oncogene product...
  85. pmc SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors
    C J McGlade
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell Biol 12:991-7. 1992
    ..The p85 alpha regulatory subunit of phosphatidylinositol (PI) 3-kinase, which associates with several receptor protein-..
  86. pmc Human T cell leukaemia virus type 2 tax protein mediates CC-chemokine expression in peripheral blood mononuclear cells via the nuclear factor kappa B canonical pathway
    C S Barrios
    Infectious Diseases Division, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA Research Service 151 I, Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI, USA
    Clin Exp Immunol 175:92-103. 2014
    ..Results showed a significant release of MIP-1α, MIP-1β and RANTES by PBMCs after the activation of p65/RelA and p50. The secretion of these CC-chemokines was significantly reduced (P < 0·05) by canonical NF-κB signalling ..
  87. ncbi Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes
    Atsushi Miura
    Research Service, James A Haley Veterans Hospital, and Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Biochemistry 43:15503-9. 2004
    ..Knockout of IRS-1 or IRS-2 also inhibited insulin-induced increases in Cbl binding to the p85 subunit of PI3K, which, along with IRS-1/2, may be required for activation of PI3K, aPKC, and glucose transport ..
  88. pmc Enterovirus 71 2C Protein Inhibits NF-κB Activation by Binding to RelA(p65)
    Haiwei Du
    MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100176, PR China
    Sci Rep 5:14302. 2015
    ..By interaction with IPT domain of p65, 2C reduces the formation of heterodimer p65/p50, the predominant form of NF-κB...
  89. ncbi Lateralization of auditory sensory gating and neuropsychological dysfunction in schizophrenia
    Robert J Thoma
    Psychiatry Service, Department of Radiology, New Mexico VA Health Care System, VAMC 116A, 1501 San Pedro SE, Albuquerque, NM 87108, USA
    Am J Psychiatry 160:1595-605. 2003
    ..However, the standard EEG measure of sensory gating using the P50 component at electrode Cz does not foster differential assessment of left and right hemisphere contributions...
  90. pmc Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase
    Hashem A Dbouk
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA
    PLoS ONE 8:e63833. 2013
    ..The mutation increases basal p110β activity, but does not affect activation of p85/p110β dimers by phosphopeptides or Gβγ...
  91. ncbi Inhibition of inducible nitric oxide synthesis by azathioprine in a macrophage cell line
    Thomas Moeslinger
    Institute of Physiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Life Sci 79:374-81. 2006
    ..Nuclear translocation of NF-kappaB p65 subunit and binding of NF-kappaB p50 subunit from nuclear extracts to a biotinylated-consensus sequence was unaffected by azathioprine treatment...
  92. doi A novel long non-coding RNA-ARA: adriamycin resistance-associated
    Min Jiang
    Comprehensive Breast Health Centre, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China Department of Breast Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
    Biochem Pharmacol 87:254-83. 2014
    ..ARA is derived from an intron of PAK3 gene, predicted to contain several stable hairpins in secondary structure and has conservative sequences in ..
  93. ncbi Calpain contributes to silica-induced I kappa B-alpha degradation and nuclear factor-kappa B activation
    F Chen
    Department of Pathology, Pennsylvania State University Collage of Medicine, Milton S Hershey Medical Center, Hershey 17033, USA
    Arch Biochem Biophys 342:383-8. 1997
    ..In fact, chloroquine enhances the signal-induced nuclear expression of NF-kappa B p50/p65 heterodimer by inhibiting the resynthesis of I kappa B alpha...
  94. ncbi Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle
    P R Shepherd
    Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 272:19000-7. 1997
    ..material adsorbed onto the phosphopeptide beads revealed the presence of p85alpha, p85beta, p55(PIK)/p55gamma, and p50 adapter subunit isoforms...
  95. pmc Torque teno virus (SANBAN isolate) ORF2 protein suppresses NF-kappaB pathways via interaction with IkappaB kinases
    Hong Zheng
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China
    J Virol 81:11917-24. 2007
    ..analysis, we proved that the TTV ORF2 protein did not alter the level of NF-kappaB expression but prevented the p50 and p65 subunits from entering the nucleus due to the inhibition of IkappaBalpha protein degradation...
  96. pmc Role of NF-κB in the skeleton
    Deborah Veis Novack
    Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Cell Res 21:169-82. 2011
    Since the discovery that deletion of the NF-κB subunits p50 and p52 causes osteopetrosis in mice, there has been considerable interest in the role of NF-κB signaling in bone...
  97. doi Guggulsterone blocks IL-1beta-mediated inflammatory responses by suppressing NF-kappaB activation in fibroblast-like synoviocytes
    Young Rae Lee
    Department of Biochemistry, Medical School and Institute for Medical Sciences, Chonbuk National University, Jeonju, Jeonbuk, 561 756, Republic of Korea
    Life Sci 82:1203-9. 2008
    ..Although the NF-kappaB binding activity and nuclear p50 and p65 subunit levels, as well as IkappaBalpha degradation in the cytoplasm was greater in cells stimulated with ..
  98. ncbi Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma
    Cornelia Czupalla
    Institut für Biochemie und Molekularbiologie II, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    J Biol Chem 278:11536-45. 2003
    ..In this study, in vitro autophosphorylation of the G protein-sensitive p85-coupled class I(A) PI3K beta and p101-coupled class I(B) PI3K gamma was examined...
  99. doi A functional insertion/deletion polymorphism in the promoter region of NFKB1 gene increases susceptibility for nasopharyngeal carcinoma
    Bin Zhou
    Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, PR China
    Cancer Lett 275:72-6. 2009
    ..insertion/deletion polymorphism (-94 insertion/deletion ATTG) in the promoter of NFKB1 gene, which encodes the p50 subunit of NF-kappaB protein complex, was recently identified...
  100. doi Nuclear factor-kappaB activation is associated with somatic and germ line RET mutations in medullary thyroid carcinoma
    Pilar Gallel
    Department of Pathology and Molecular Genetics, Hospital Universitari Arnau de Vilanova, University of Lleida, Institut de Recerca Biomedica de Lleida, 25198 Lleida, Spain
    Hum Pathol 39:994-1001. 2008
    ..Immunohistochemical evaluation included members of the NF-kappaB (p50, p65, p52, c-Rel, RelB) family, as well as putative targets of NF-kappaB such as Flip, Bcl-xL, and cyclin D1...
  101. pmc Macrophages modulate migration and invasion of human tongue squamous cell carcinoma
    Emma Pirilä
    Oulu Center for Cell Matrix Research, University of Oulu, Oulu, Finland Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland Oulu Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
    PLoS ONE 10:e0120895. 2015
    ..M2 Mfs had an excess of NF-kappaB p50 subunit and a lack of p65 subunits both in the presence and absence of HSC-3 cells, indicating dysregulation and ..

Research Grants73

  1. Investigation of Gene Regulation by NF-kappaB Transcription factors
    Gourisankar Ghosh; Fiscal Year: 2012
    ..The combinatorial NF-?B dimers are formed from five family members;p50, p52, RelA (p65), cRel and RelB...
  2. NF-kB regulation by p105 and p100
    Gourisankar Ghosh; Fiscal Year: 2013
    ..NF-?B1 (also called p105/p50) and NF-?B2 (also called p100/p52) belong to both the NF-?B and I?B families...
  3. MOLECULAR CONTROL OF LIVER REGENERATION
    Rebecca Taub; Fiscal Year: 2000
    ..PHF/NF-Kappa B by analyzing the regenerative capacity of mouse livers from animals that are genetically missing the p50 subunit of PHF/NF-Kappa B...
  4. Small Molecule Inhibitors of the Transcriptional Activators ESX and NF-kB
    Anna K Mapp; Fiscal Year: 2013
    ..small (drug-like) molecules that inhibit the function of two transcriptional activators, ESX and NF- kappaB (p50/p65 heterodimer) implicated in approximately 30% of breast cancers...
  5. Use p105(sr) to study p50 homodimer in skin tumor/cancer
    Li Lin; Fiscal Year: 2009
    ..However, unlike other types of cancers where NF-kappaB heterodimer p50/RelA activity is elevated, chemical-induced skin papillomas and squamous cell carcinomas (SCC), exhibit ..
  6. Regulation and Function of hVps34 in Insulin Signaling
    Jonathan M Backer; Fiscal Year: 2010
    ..While the function of p85/p110 PI 3-kinases in insulin responsive cells is well documented, the Class III PI 3-kinase, hVps34, also plays an ..
  7. Non-apoptotic functions of caspases
    STEVEN MILES FRISCH; Fiscal Year: 2012
    ..the calpain-mediated cleavage of guanine nucleotide exchange factors (GEFs) for Rac and/or by regulating the p85 subunit of PI3- Kinase...
  8. SECOND MESSENGERS IN THE RETINA
    RAJU VS RAJALA; Fiscal Year: 2012
    ..Interestingly, conditional deletion of p85[unreadable], which regulates class IA PI3K, from cones resulted in an age-related cone degeneration...
  9. Role of NF-kB in hematopoietic stem cells and leukemia-initiating cell formation
    Christopher A Klug; Fiscal Year: 2013
    ..applicant): Constitutive activation of the classical NF-?B pathway, which principally involves RelA/p65, c-Rel, and p50, has been observed in human acute myeloid leukemia (AML) where constitutive NF-?B DNA-binding activity has been ..
  10. Role of PI 3-Kinase isoforms in insulin action
    C Ronald Kahn; Fiscal Year: 2013
    ..This includes differences in the activity and properties of the different regulatory (p85) and catalytic (p110) subunits of PI 3-kinase;important effects of stoichiometry between regulatory and catalytic ..
  11. In Vivo MicroCT Scanner
    Roberto Pacifici; Fiscal Year: 2010
    ..Beck, L.W.K. Chung, M.S. Nanes, Dr. H. Shim M.N. Weitzmann, W. Lewis, who are PI for 7 RO-1s and 1 P0-1, 1 P20, 1 P50 and 1 VA merit grant, and run research programs, on bone, HIV- AIDS, nanoparticles, and cancer at Emory University...
  12. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..carried out at 3 time points: at 1 h post reperfusion for I?B[unreadable], phosphorylation of MAP kinases, nuclear p50;at 3 h post reperfusion for RT-PCR to quantify lung mRNA concentrations of TNF-[unreadable], MIP-1[unreadable], and ..
  13. p85/p110 PI3 Kinase-Structure, function and Physiology
    Jonathan M Backer; Fiscal Year: 2013
    ..The Class IA PI 3-kinase is a dimer containing distinct regulatory (p85) and catalytic (p110) subunits, both of which are frequently mutated in human cancer...
  14. P3K, RETROVIRAL ONCOGENE AND HOMOLOG OF PI 3-KINASE
    Peter K Vogt; Fiscal Year: 2013
    ..analysis will concentrate on the interactions between p110[unreadable] and Ras as well as p110[unreadable] and p85. These interactions are critical to the oncogenicity of p110[unreadable];they are fundamentally changed in the ..
  15. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..Specific analyses will be carried out at 3 time points: at 1 h post reperfusion for IkB[unreadable], nuclear p50, and phosphorylation of mitogen activated protein kinases (MAPKs - ERK, p38, JNK);at 3h post reperfusion for RT-PCR ..
  16. Selective Insulin Resistance- Diabetic Cardiovascular Diseases
    George L King; Fiscal Year: 2013
    ..2) Identify the role of phospho-Thr86 of p85/PI3K in causing selective insulin resistance in EC and correlate the changes of phospho-Thr86/p85 with vascular ..
  17. Center for the Spatiotemporal Modeling of Cell Signaling (STMC)
    Bridget S Wilson; Fiscal Year: 2013
    ..This application proposes the STMC for recognition as the first P50 National Center for Systems Biology in the Southwestern USA...
  18. Akt-regulated pathways in platelet function
    Donna S Woulfe; Fiscal Year: 2011
    ..Our preliminary studies show that arrestins form agonist-dependent complexes with p85-PI3K subunits in human platelets...
  19. RGS: A Molecular Switch Regulating Irreversible ASM Growth/Contraction in Asthma
    REYNOLD ALEXANDER PANETTIERI; Fiscal Year: 2012
    ..of regulators of G-protein signaling (RGS) proteins which inactivate G proteins and co-localize with phospho-p85 (p-p85) PI3K to facilitate S6K1 activation...
  20. PI3K Signaling in Juvenile Myelomonocytic Leukemia
    CHARLES B GOODWIN; Fiscal Year: 2013
    ..of both PI3K regulatory subunits p851 and p852, with activating PTPN11 mutants to explore the hypothesis that both p85 subunits contribute to gain-of-function mutant Shp2-mediated GM-CSF hypersensitivity...
  21. Center of Cancer Nanotechnology Excellence Focused on Therapy Response
    Sanjiv S Gambhir; Fiscal Year: 2010
    ..We also have direct links to a UCLA Prostate SPORE, the ICMIC P50 and ICBP P20 at Stanford as well as several other NCI sponsored efforts...
  22. Survival Mechanisms in Leukemic NK Cells
    THOMAS PATRICK LOUGHRAN; Fiscal Year: 2013
    ..Constitutive overexpression of Rac1, PAK3, RhoB and ROCK1, potential downstream effectors of S1PR5, is observed in leukemic NK cells...
  23. Combinatorial Approach for Reducing Invasive Potential of Melanoma Cells
    Farrukh Afaq; Fiscal Year: 2013
    ..found that fisetin treatment reduced melanoma cell invasion by inhibiting the protein expression of PI3K (p110a and p85) and phosphorylation of AKT at Ser473 and Thr308...
  24. Functional Characterization of Risk Genes for Psychotic Illness in the GWAS Era
    Mei Hua Hall; Fiscal Year: 2013
    ..Previous studies indicate that four neurophysiologic traits (i.e., P300 amplitude and latency, P50 inhibition, and Gamma band response) are putative endophenotypes for psychotic illness and capture three important ..
  25. Structure-directed investigations into the regulation of Ste20 kinases
    Benjamin E Turk; Fiscal Year: 2013
    ..Whereas the molecular basis for how type I PAKs (PAK1, PAK2 and PAK3) are regulated by inter- molecular autoinhibition is well established, the type II PAKs are not regulated by the ..
  26. Bipolar &Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Godfrey D Pearlson; Fiscal Year: 2012
    ..We will obtain measures of neurophysiology (e.g., eye tracking, P50 gating, PPI, and P300), neurocognition (e.g...
  27. Bipolar &Schizophrenia Consortium for Parsing Intermediate Phenotypes
    John A Sweeney; Fiscal Year: 2010
    ..We will obtain measures of neurophysiology (e.g., eye tracking, P50 gating, PPI, and P300), neurocognition (e.g...
  28. Bipolar &Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Carol A Tamminga; Fiscal Year: 2012
    ..We will obtain measures of neurophysiology (e.g., eye tracking, P50 gating, PPI, and P300), neurocognition (e.g...
  29. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Matcheri S Keshavan; Fiscal Year: 2010
    ..We will obtain measures of neurophysiology (e.g., eye tracking, P50 gating, PPI, and P300), neurocognition (e.g...
  30. BIOCHEMICAL STUDIES OF HUMAN DNA POLYMERASE DELTA
    Marietta Y Lee; Fiscal Year: 2012
    ..Pol [unreadable] and its subassemblies to make a rigorous biochemical comparisons of the core enzyme (p125/p50), core + p12, core + p68 and the holoenzyme...
  31. Gene-Environment Interactions for Cortical Development and Schizophrenia
    Akira Sawa; Fiscal Year: 2013
    ..b>P50 Schizophrenia Research Center at Johns Hopkins, therefore, is to address the key question of how defects of ..
  32. Schizophrenia Gating Deficit Mechanisms: Extending the Circuit
    JOSE MIGUEL CANIVE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The P50 sensory gating deficit, measured via EEG, has been established as a strong potential endophenotype in genetic studies of schizophrenia...
  33. Single-cell analysis of TNF-induced signaling, transcription and fate decisions
    Suzanne Gaudet; Fiscal Year: 2013
    ..Finally, we will use protein-binding microarrays to ask how competition between p65-p50 heterodimers and p50-p50 homodimers contributes to decoding NF-kB activation and to cell line-to-cell line ..
  34. Role of Integrins/ECM in Controlling IGF-I Actions
    David Robert Clemmons; Fiscal Year: 2013
    ..We will deter- mine the role of SHP-2 transfer to p85 in regulating the activation of Rac-1 and Cdc-42. The necessity of SHP...
  35. Protein radicals in microglia: environmental mechanisms of chronic neurotoxicity
    Michelle L Block; Fiscal Year: 2013
    ..Thus, beginning with the NF:2 p50 radical, we will test the specific hypothesis that paraquat, LPS, and MPTP/MPP+ cause microglial protein radicals ..
  36. Impact of obesity on airway responses to air pollution
    Stephanie A Shore; Fiscal Year: 2013
    ..We will use EMSA and Western blotting for I?B, p50, and p65 to determine O3-induced NF-?B activation is increased in obese mice...
  37. Enteric Neuronal Development as a Determinant of Intestinal Inflammation
    Kara Gross Margolis; Fiscal Year: 2013
    ..scores, intestinal expression of genes encoding proinflammatory molecules, levels of neutrophil elastase and p50 NF B) of TNBS- and DSS-induced colitis are higher in NSE- noggin and lower in Hand2+/- mice than in their wild-type ..
  38. Mechanisms of H. pylori-Induced Hypochlorhydria
    Adam J Smolka; Fiscal Year: 2010
    ..pylori cag PAI genes repress HK1 promoter constructs transfected into gastric cells by promoting NF-:B p50 homodimer binding to an HK1 cis-response element...
  39. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey C Murray; Fiscal Year: 2013
    ..to secure funding for ultrasound and 3D facial imaging instruments as part of a supplement to our now expiring P50 grant but there are no funds to subphenotype beyond this year, We will do the 3D imaging, 00 ultrasounds, dental ..
  40. Curcumin and chemoprevention of H. pylori-associated gastric carcinogenesis
    Rupesh Chaturvedi; Fiscal Year: 2013
    ..pylori activated Macs to a tolerant regulatory phenotype in a NF-kB1 (p105/p50)-dependent manner. Tolerance may lead to persistence of H...
  41. Mechanisms of Receptor Regulated Na+-H+ Exchange
    Diane L Barber; Fiscal Year: 2013
    ..on how phosphoinositide 3-kinase is pH sensitive, based on our recent structural and biochemical findings that its p85 regulatory subunit is a pH sensor...
  42. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
    ..are the cytoprotective effects of TRAF2 mediated by activation of the type 1 NF-?B pathway, and if so are p65 and p50 homo or heterodimers involved (Specific Aim 1)? Second, is dysferlin necessary for the cytoprotective effects of ..
  43. A Novel Human DNA Damage Response Which Directly Alters DNA Polymerase Delta
    CHRISTINE ELIZABETH LEROY; Fiscal Year: 2013
    ..The enzyme consists of four subunits: p125 and p50 which make up the catalytic core, and p68 and p12, which provide the enzyme increased stability, enhanced activity, ..
  44. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Gunvant K Thaker; Fiscal Year: 2010
    ..We will obtain measures of neurophysiology (e.g., eye tracking, P50 gating, PPI, and P300), neurocognition (e.g...
  45. The Wake Forest Center for Botanical Lipids and Inflammatory Disease Prevention
    Floyd H Chilton; Fiscal Year: 2013
    ..provided by applicant): The Center for Botanical Lipids and Inflammatory Disease Prevention is a new version of a P50 at Wake Forest University Health Sciences that has been continuously funded since 2005...
  46. NF-kB mediated induction of VEGFR-3 and new lymphatic vessels in breast cancer
    Sophia Ran; Fiscal Year: 2013
    ..is also presented that in lymphatic endothelial cells (LECs) VEGFR-3 expression might be regulated by both the p50 subunit of NF-?B and the lymphatic-specific transcription factor, Prox1...
  47. JAK2 signaling in erythropoiesis
    LILY JUNSHEN HUANG; Fiscal Year: 2013
    ..This process involves a new function of the p85 subunit of PI3K and is PI3K kinase activity-independent...
  48. Mechanisms of Reovirus-Induced Apoptosis
    Terence S Dermody; Fiscal Year: 2011
    ..Following reovirus infection, mice deficient in the p50 subunit of NF-icB display diminished apoptosis in the brain, yet enhanced apoptosis in the heart, as compared to ..
  49. Role of cGMP in Ventilator-Induced Lung Endothelial Barrier Dysfunction
    David B Pearse; Fiscal Year: 2013
    ..of TNFa, p38, MK2 and NF?B using specific inhibitors, siRNA, as well as TNFa -/-, TNFa Receptor1-/-, MK2-/-, and p50-/- mice to dissect the involvement of each signaling pathway...
  50. Botanical Estrogens: Mechanisms, Dose and Target Tissues
    William G Helferich; Fiscal Year: 2013
    ..and cellular findings will also be relevant in guiding and interpreting the work in other projects in this P50 program...
  51. Mitigation of the Catecholamine Surge in Severely Burned Patients
    David N Herndon; Fiscal Year: 2013
    ..The uniqueness and innovation of this P50 Burn Center project is that for the first time, the fundamental mechanisms of the burn-induced stress phenotype and ..
  52. Center for Neuroregulation in Alcohol Dependence (CeNiAD)
    Andrew J Saxon; Fiscal Year: 2010
    ..opportunities, intellectual milieu and planning process to justify an application for a future new Specialized P50 Alcohol Research Center...
  53. The Ontogeny of Social Visual Engagement in Infants at Risk for Autism
    Warren Jones; Fiscal Year: 2012
    ..and technological advancements resulting from our continuing studies of young children with ASD (Project 1, P50 HD055726)...
  54. Social Media Intervention for Young Adult Smokers
    Danielle E Ramo; Fiscal Year: 2013
    ..The UCSF Department of Psychiatry and the NIDA-funded San Francisco Treatment Research Center (P50 DA009253) provide an exceptional research environment...
  55. EBV EXPRESSION IN NASOPHARYNGEAL CARCINOMA
    NANCY JOAN RAAB-TRAUB; Fiscal Year: 2013
    ..Our specific aims are: 1.) Identify the epithelial cellular targets that are regulated by LMP1-CTAR1 through the p50/p50-Bcl-3 transcriptional complex and activated STAT3 using chromatin immunoprecipitation (ChIP) analysis and ChIP-..
  56. Mechanisms of Hematopoietic Stem Cell Maintenance
    Emmanuelle Passegue; Fiscal Year: 2013
    ..e., Faslpr/lpr, hematopoietic-specific Caspase-8cKO, p50-/- mice) to dissect the regulation and functional outcome of DR activation in HSCs and GMPs...
  57. Polypeptide modification for enhanced brain delivery
    Alexander V Kabanov; Fiscal Year: 2013
    ..The previous work produced a conjugate of leptin with Pluronic P85 that is centrally active, has a long half-life in blood, is enzymatically resistant, crosses the BBB by a non-..
  58. Role of Mitochondrial Respiratory Stress Signaling in Cancer Progression
    Narayan G Avadhani; Fiscal Year: 2013
    ..hnRNPA2, a common transcription co-activator that functionally synergizes the activity of promoter bound cRel/p50, C/EBP[unreadable], CREB and NFAT transcription factors...
  59. Finding Small Molecules that Modulate Gene Expression
    Philip H Bolton; Fiscal Year: 2010
    ..are many neurological transcription systems that may be amenable to this approach including the c-Rel, RelA and p50 heterodimer and homodimer transcription factors as well as those of the CREB and CREM transcription factors that ..
  60. The Iowa Center for Molecular Auditory Neuroscience
    Steven H Green; Fiscal Year: 2013
    ..Physiology, and Communication Sciences and Disorders, with 15 auditory-related R01s, nine funded by NIDCD, a P50, two T32s, and other grants, for a total current year direct cost >$9M...
  61. PTSD-like phenotype of mice lacking GIT2
    Richard T Premont; Fiscal Year: 2011
    ..A deeper understanding of how GIT2 functions to regulate anxiety and the extinction of fear may provide insights into human fear and anxiety disorders such as PTSD. ..
  62. The role of BRD7 in the regulation of endoplasmic reticulum and glucose homeostas
    Sang Won Park; Fiscal Year: 2013
    ..in obesity condition and that its interaction with the regulatory subunits of phosphatidyl-inositol3-kinase (PI3K), p85[unreadable] and p85[unreadable], is crucial for its function...
  63. ER Stress, Insulin Signaling and Metabolism
    Umut Ozcan; Fiscal Year: 2011
    ..Our recent findings implicate p85&#945;and p85&#946;, the regulatory subunits of Phosphatidyl Inositol 3-Kinase (PI3K), as obligatory ..
  64. Interdisciplinary Center on Epigenetics Science and Society
    Nancy Press; Fiscal Year: 2012
    ..Health, and with links to the University of Washington's Center for Genomics and Healthcare Equality (P50), will engage in a range of activities to support the following Specific Aims: (1) Create an interdisciplinary ..
  65. Emerging Helminthiases in China: Genetic Diversity,
    Zheng Feng; Fiscal Year: 2006
    This revised version of our TMRC P50 application, re-titled "Emerging Helminthiasis in China: Genetic Diversity, Transmission Dynamics, and the Impact of Environmental Changes", has been prepared to reflect and incorporate the ..
  66. THE USE OF ELECTROACUPUNCTURE TO MODULATE AROUSAL
    Edgar Garcia Rill; Fiscal Year: 2002
    DESCRIPTION (APPLICANT'S ABSTRACT): The vertex-recorded midlatency auditory evoked P50 potential is a measure of the output of the reticular activating system (RAS)...
  67. INDUCTION OF ACUTE PHASE PROTEIN BIOSYNTHESIS
    David Samols; Fiscal Year: 2004
    ..We recently found that the re1 protein p50 participates in IL-6induced CRP expression in two unexpected ways: 1) p50 binds to a non-consensus kappaB site ..
  68. CHRONIC COCAINE ABUSE EFFECTS ON P50 AND P3A ERPS
    George Fein; Fiscal Year: 2001
    DESCRIPTION: (Applicant's Abstract) The research goals are to use P50 and P3A event-related potentials (ERPs) to (1) study chronic cocaine abuse effects on CNS information processing, (2) to compare these effects with the effects of ..
  69. ATYPICAL ANTIPSYCHOTICS AND P50 GATING IN SCHIZOPHRENIA
    Lawrence Adler; Fiscal Year: 2001
    ..This can be demonstrated using a P50 auditorv evoked potential paradigm...
  70. CHITINASES IN PARASITIC HELMINTHS
    Patricia Komuniecki; Fiscal Year: 2005
    ..However, recently we have reported a novel, developmentally regulated, family 19 glycosyl hydrolase (As-p50) from the parasitic nematode, Ascaris suum-the first documented occurrence of such an enzyme in an animal species...
  71. GTP BINDING PROTEINS AND INSULIN RECEPTOR SINGNALING
    CHIN SUNG; Fiscal Year: 1999
    ..stimulation of rat HTC hepatoma and other cells one or more signaling complexes form that consists of: the IR; the p85 subunit of phosphatidylinositol-3-kinase; Ras GTPase activating protein (GAP); and p62 GAP-associated protein...
  72. IL2 RECEPTORS--ANALYSIS OF ASSEMBLY AND SIGNALING
    Warner Greene; Fiscal Year: 1999
    ..receptor is now recognized as a multimeric membrane complex composed of a least three distinct chains termed alpha (p50, Tac), beta (p70-75), and gamma-c (p64)...
  73. GENETICS OF PSYCHOPHYSIOLOGICAL SCHIZOPHRENIA PHENOTYPES
    Hilary Coon; Fiscal Year: 2000
    ..from variables measuring psychophysiological endopheno-types of smooth pursuit eye movement (SPEM), and the P50 evoked auditory response to investigate the genetics of schizophrenia...