ARG1

Summary

Gene Symbol: ARG1
Description: arginase 1
Alias: arginase-1, arginase, liver, liver-type arginase, type I arginase
Species: human

Top Publications

  1. ncbi Liver-type arginase in serum during and after liver transplantation: a novel index in monitoring conditions of the liver graft and its clinical significance
    M Ikemoto
    College of Medical Technology, Kyoto University, Japan
    Clin Chim Acta 271:11-23. 1998
  2. pmc Extracellular activation of arginase-1 decreases enterocyte inducible nitric oxide synthase activity during systemic inflammation
    Keita Miki
    Departments of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Gastrointest Liver Physiol 297:G840-8. 2009
  3. doi Nature of myeloid cells expressing arginase 1 in peripheral blood after trauma
    Jodie A Bryk
    Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 68:843-52. 2010
  4. doi Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response
    Judith M Vonk
    Department of Epidemiology, University Medical Center Groningen, The Netherlands
    Pharmacogenet Genomics 20:179-86. 2010
  5. doi Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma
    Michelle L North
    Institutes of Medical Sciences, Dalla Lana School of Public Health, Faculty of Medicine, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 296:L911-20. 2009
  6. pmc Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes
    Timea Beleznai
    Department of Pharmacology, University of Oxford, Oxford, United Kingdom
    Am J Physiol Heart Circ Physiol 300:H777-83. 2011
  7. doi Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation
    Rita Rotondo
    Departments of Experimental Medicine, University of Genova, Genova, Italy
    J Leukoc Biol 89:721-7. 2011
  8. pmc S-nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase
    Jessilyn Dunn
    Johns Hopkins University School of Medicine, 720 Rutland Ave Ross 1150, Baltimore, MD 21205, USA
    Mol Cell Biochem 355:83-9. 2011
  9. ncbi Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils
    Lars C Jacobsen
    Granulocyte Research Laboratory, Department of Hematology, Rigshospitalet University Hospital, Copenhagen, Denmark
    Blood 109:3084-7. 2007
  10. doi Arginase-1 expression in granulomas of tuberculosis patients
    Ana P Pessanha
    Departamento de Patologia e Laboratorios, Disciplina de Anatomia Patológica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
    FEMS Immunol Med Microbiol 66:265-8. 2012

Research Grants

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
  2. Keith T Wilson; Fiscal Year: 2016
  3. Keith T Wilson; Fiscal Year: 2016
  4. Michal A Olszewski; Fiscal Year: 2016
  5. ROBERT MATTHEW TIGHE; Fiscal Year: 2016
  6. NITRIC OXIDE AND OXYGENATION IN DIABETIC KIDNEYS
    NILS AXEL FREDRIK PALM; Fiscal Year: 2010
  7. Buddy Ullman; Fiscal Year: 2016
  8. Role of TAM Arginase 1 in Tumor Progression
    Joseph E Qualls; Fiscal Year: 2011
  9. DAVID FEOLA; Fiscal Year: 2016
  10. Jeffrey A Kline; Fiscal Year: 2015

Detail Information

Publications340 found, 100 shown here

  1. ncbi Liver-type arginase in serum during and after liver transplantation: a novel index in monitoring conditions of the liver graft and its clinical significance
    M Ikemoto
    College of Medical Technology, Kyoto University, Japan
    Clin Chim Acta 271:11-23. 1998
    ..These results suggest that liver-type arginase behaves uniquely in the serum among many hepatic enzymes, and could serve as a distinct marker of hepatic lesions, particularly during and after liver transplantation...
  2. pmc Extracellular activation of arginase-1 decreases enterocyte inducible nitric oxide synthase activity during systemic inflammation
    Keita Miki
    Departments of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Gastrointest Liver Physiol 297:G840-8. 2009
    ..Thus reciprocal activation of arginase-1 and modulation of mucosal iNOS activity may be protective because it would be expected to decrease NO(*)-dependent intestinal barrier dysfunction on that basis...
  3. doi Nature of myeloid cells expressing arginase 1 in peripheral blood after trauma
    Jodie A Bryk
    Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 68:843-52. 2010
    Myeloid cells that express arginase 1 are upregulated by different stimuli, including trauma, and are capable of depleting arginine from the surrounding environment...
  4. doi Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response
    Judith M Vonk
    Department of Epidemiology, University Medical Center Groningen, The Netherlands
    Pharmacogenet Genomics 20:179-86. 2010
    Arginase probably plays an important role in asthma development, severity and progression. Polymorphisms in arginase 1 and arginase 2 genes have been associated with childhood asthma and FEV1 reversibility to beta2 agonists.
  5. doi Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma
    Michelle L North
    Institutes of Medical Sciences, Dalla Lana School of Public Health, Faculty of Medicine, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 296:L911-20. 2009
    ..To investigate the role of arginase isozymes (ARG1 and ARG2) in AHR, we determined the protein expression of ARG1, ARG2, the NOS isozymes, and other proteins involved ..
  6. pmc Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes
    Timea Beleznai
    Department of Pharmacology, University of Oxford, Oxford, United Kingdom
    Am J Physiol Heart Circ Physiol 300:H777-83. 2011
    b>Arginase 1, via competing with nitric oxide (NO) synthase for the substrate L-arginine, may interfere with NO-mediated vascular responses...
  7. doi Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation
    Rita Rotondo
    Departments of Experimental Medicine, University of Genova, Genova, Italy
    J Leukoc Biol 89:721-7. 2011
    b>ARG1, expressed by human PMNs, inhibits T cell proliferation by depleting extracellular L-arginine...
  8. pmc S-nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase
    Jessilyn Dunn
    Johns Hopkins University School of Medicine, 720 Rutland Ave Ross 1150, Baltimore, MD 21205, USA
    Mol Cell Biochem 355:83-9. 2011
    ..We have recently shown that inducible nitric oxide synthase (NOS2) S-nitrosates and activates arginase 1 (Arg1) leading to age-associated vascular dysfunction...
  9. ncbi Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils
    Lars C Jacobsen
    Granulocyte Research Laboratory, Department of Hematology, Rigshospitalet University Hospital, Copenhagen, Denmark
    Blood 109:3084-7. 2007
    b>Arginase 1 (ARG1) metabolizes arginine, thus reducing the availability of arginine as a substrate for nitric oxide synthase (NOS)...
  10. doi Arginase-1 expression in granulomas of tuberculosis patients
    Ana P Pessanha
    Departamento de Patologia e Laboratorios, Disciplina de Anatomia Patológica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
    FEMS Immunol Med Microbiol 66:265-8. 2012
    ..with the ability of mouse macrophages to produce antibactericidal nitric oxide, by inducing the expression of arginase 1 (Arg1). It remains unclear whether this pathway has a role in humans infected with Mtb...
  11. pmc Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima media thickness
    Julie Dumont
    J Med Genet 44:526-31. 2007
    ..Recently, it was suggested that arginase (ARG)1 plays an important role in atherogenesis. However, because of its complex functions depending on vascular cell type, its impact on atherogenesis remains unclear...
  12. pmc Hepatitis C virus targets over-expression of arginase I in hepatocarcinogenesis
    Wenjun Cao
    Department of Laboratory Medicine, Shanghai Second Medical University, Affiliated Ruijin Hospital, Shanghai, China
    Int J Cancer 124:2886-92. 2009
    ..The results showed that arginase 1 mRNA and protein were elevated about threefold in HCV positive compared with negative cells (p < 0.01)...
  13. pmc Recent advances in arginine metabolism: roles and regulation of the arginases
    Sidney M Morris
    Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Br J Pharmacol 157:922-30. 2009
    ....
  14. pmc Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms
    Benjamin C Yan
    Department of Pathology, University of Chicago Medical Center, Chicago, IL 60637, USA
    Am J Surg Pathol 34:1147-54. 2010
    ..Arg-1 represents a sensitive and specific marker of benign and malignant hepatocytes that may ultimately prove to be a useful diagnostic tool in routine surgical pathology practice...
  15. doi Serum levels of arginase I are associated with left ventricular function after myocardial infarction
    Seldag Bekpinar
    Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa 34093, Istanbul, Turkey
    Clin Biochem 44:1090-3. 2011
    ..We aimed to evaluate the impact of arginase and ADMA levels on left ventricular function after myocardial infarction (MI)...
  16. doi Arginase I and the very low-density lipoprotein receptor are associated with phenotypic biomarkers for obesity
    Oh Yoen Kim
    Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Republic of Korea
    Nutrition 28:635-9. 2012
    ..e., hypertension, dyslipidemia, and cardiovascular disease). We examined whether the mRNA of tested genes were linked to blood lipid concentrations and vascular endothelial function as features of obesity...
  17. doi Arginase-1: a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology
    Ryan McKnight
    Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, Georgia 30322, USA
    Cancer Cytopathol 120:223-9. 2012
    ..Previous studies have demonstrated the efficacy of HepPar-1 and glypican-3 (GPC-3) IHC in liver fine needle aspiration (FNA) cytology...
  18. ncbi Prenatal diagnosis for arginase deficiency by second-trimester fetal erythrocyte arginase assay and first-trimester ARG1 mutation analysis
    Stanley H Korman
    Department of Clinical Biochemistry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Prenat Diagn 24:857-60. 2004
    ..neurometabolic disorder caused by deficiency of hepatic cytosolic arginase I, resulting from mutations in the ARG1 gene. We diagnosed arginase deficiency in a three-year-old male child of first-cousin Palestinian Arab parents...
  19. pmc Vascular dysfunction in retinopathy-an emerging role for arginase
    Ruth B Caldwell
    Vascular Biology Center, Department of Cellular Biology and Anatomy, VA Medical Center, Augusta, GA 30912, USA
    Brain Res Bull 81:303-9. 2010
    ..in oxidative stress and signs of vascular inflammation are correlated with increases in arginase activity and arginase 1 expression and that decreasing arginase expression or inhibiting its activity blocks these effects...
  20. ncbi Structural organization of the gene for rat liver-type arginase
    A Ohtake
    Institute for Medical Genetics, Kumamoto University Medical School, Japan
    J Biol Chem 263:2245-9. 1988
    ..1.3.3) and for human argininosuccinate synthetase (EC 6.3.4.5), other two enzymes of the urea cycle...
  21. ncbi Developmental and hormonal regulation of the Xenopus liver-type arginase gene
    Q Xu
    Laboratory of Developmental Biochemistry, National Institute for Medical Research, Mill Hill, London, England
    Eur J Biochem 211:891-8. 1993
    ..They also demonstrate that this gene can be exploited as a target for thyroid hormones in further studies to analyze the mechanisms underlying the establishment of the adult phenotype during amphibian metamorphosis...
  22. pmc The immunomodulatory glycan LNFPIII initiates alternative activation of murine macrophages in vivo
    Olga Atochina
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Immunology 125:111-21. 2008
    ..if LNFPIII stimulation of macrophages in vivo initiates alternative activation events such as upregulation of Arginase 1, Ym1, FIZZ-1, MGL-1 or macrophage mannose receptor (MMR)...
  23. pmc Arginase 1 regulation of nitric oxide production is key to survival of trophic factor-deprived motor neurons
    ALVARO G ESTEVEZ
    Burke Medical Research Institute, White Plains, New York 10605, USA
    J Neurosci 26:8512-6. 2006
    ..When we transfected arginase 1 into motor neurons to see whether it alone could abrogate trophic factor deprivation-induced death, we found ..
  24. ncbi Genomics of foam cells and nonfoamy macrophages from rabbits identifies arginase-I as a differential regulator of nitric oxide production
    Anita C Thomas
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, BS2 8HW, United Kingdom
    Arterioscler Thromb Vasc Biol 27:571-7. 2007
    ..We sought to identify genes differentially regulated in foam cells, since these are likely to include new targets for intervention...
  25. pmc Arginase activity mediates retinal inflammation in endotoxin-induced uveitis
    Wenbo Zhang
    Vascular Biology Center, Medical College of Georgia, Augusta, GA, 30912 2500, USA
    Am J Pathol 175:891-902. 2009
    ..Immunofluorescence and flow cytometry confirmed this increase in Arg1, which was localized to glia and microglia...
  26. doi Role of arginine in superficial wound healing in man
    I B J G Debats
    Department of Plastic, Reconstructive and Handsurgery, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Nitric Oxide 21:175-83. 2009
    ..For the first time, human data support previous animal studies suggesting arginine metabolism for an NO- as well as arginase-mediated reparation of injured skin...
  27. ncbi Cloning and characterization of the mouse and rat type II arginase genes
    R K Iyer
    Department of Pathology, UCLA School of Medicine, California 90095, USA
    Mol Genet Metab 63:168-75. 1998
    ..In humans, inherited deficiency of hepatic or type I arginase results in hyperargininemia, a syndrome characterized by periodic episodes of hyperammonemia, spasticity, and ..
  28. ncbi Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line
    T Gotoh
    Department of Molecular Genetics, Kumamoto University School of Medicine, Japan
    FEBS Lett 395:119-22. 1996
    ..7 cells by lipopolysaccharide. This induction was enhanced by dexamethasone and dibutyryl cAMP, and was prevented by interferon-gamma. Possible roles of arginase II in NO synthesis are discussed...
  29. ncbi Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells
    S M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol 275:E740-7. 1998
    ..These complex patterns of expression suggest that the arginase isoforms may play distinct, although partially overlapping, functional roles in macrophage arginine metabolism...
  30. ncbi Dogmas and controversies in the handling of nitrogenous wastes: expression of arginase Type I and II genes in rainbow trout: influence of fasting on liver enzyme activity and mRNA levels in juveniles
    Patricia A Wright
    Department of Zoology, University of Guelph, Guelph, ON, Canada N1G 2W1
    J Exp Biol 207:2033-42. 2004
    ..This suggests that the cytosolic Type I arginase found in ureotelic vertebrates arose in the common ancestor of amphibia and mammals...
  31. ncbi CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress
    Valeriya P Makarenkova
    Department of Surgery, University of Pittsburgh Medical Center, PA 15213, USA
    J Immunol 176:2085-94. 2006
    ..markers invade the spleen after traumatic stress and suppress T cell function through the production of arginase 1. We created a consistent model of traumatic stress in C57BL/6 mice to perform this work...
  32. pmc Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats
    Jae Hyung Kim
    Anesthesiology, Tower 711, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, USA
    J Appl Physiol (1985) 107:1249-57. 2009
    ..These results suggest that eNOS was uncoupled in old rats. Although the expression of arginase 1 and eNOS was similar in young and old rats, inducible NOS (iNOS) was significantly upregulated...
  33. pmc Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13
    Steven L Highfill
    University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA
    Blood 116:5738-47. 2010
    ..In vivo administration of a pegylated form of human arginase-1 (PEG-arg1) resulted in L-arginine depletion and significant GVHD reduction...
  34. ncbi Chromosomal localization of the human arginase II gene and tissue distribution of its mRNA
    T Gotoh
    Department of Molecular Genetics, School of Medicine, Kumamoto University, Japan
    Biochem Biophys Res Commun 233:487-91. 1997
    ..The mRNA was either at very low levels or not detectable in the fetal kidney, lung, and liver. Thus, expression of the human arginase II gene is regulated both tissue-specifically and developmentally...
  35. ncbi Human type II arginase: sequence analysis and tissue-specific expression
    S M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, PA 15261, USA
    Gene 193:157-61. 1997
    ..The predicted sequence of human type II arginase is 58% identical to the sequence of human type I arginase but is 71% identical to the sequence of Xenopus type II arginase, suggesting that duplication of the arginase ..
  36. ncbi Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism
    M Hesse
    Schistosomiasis Immunology and Pathology Unit and Max Planck Institut für Immunbiologie, Freiburg, Germany
    J Immunol 167:6533-44. 2001
    ....
  37. ncbi Expression and activity of arginase isoenzymes during normal and diabetes-impaired skin repair
    Heiko Kämpfer
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Invest Dermatol 121:1544-51. 2003
    ....
  38. ncbi Roles of conserved residues in the arginase family
    J Perozich
    Department of Molecular Genetics and Biochemistry, School of Medicine, University of Pittsburgh, PA 15261, USA
    Biochim Biophys Acta 1382:23-37. 1998
    ..these residues were previously identified as functionally essential by analysis of inherited defects in the type I arginase gene...
  39. ncbi Expression, purification, and characterization of human type II arginase
    D M Colleluori
    Temple University School of Medicine, Department of Biochemistry, Philadelphia, Pennsylvania 19140, USA
    Arch Biochem Biophys 389:135-43. 2001
    ..3 mM. Ornithine, a product of the reaction catalyzed by arginase and a potent inhibitor of type I arginase, is a poor inhibitor of the type II isozyme...
  40. ncbi The effect of substance P and other tachykinins on inositol phospholipid hydrolysis in rabbit retina, superior colliculus and retinal cultures
    N N Osborne
    Nuffield Laboratory of Ophthalmology, University of Oxford, U K
    Vision Res 29:757-64. 1989
    ..Spantide [(D-Arg1, D-Try7.9, Leu11) substance P] and (D-Pro2, D-Try7...
  41. ncbi Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3
    R R Ryan
    Digestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:13613-24. 1998
    ..for the hBRS-3 receptor, although two low affinity antagonists for gastrin-releasing peptide and NMB receptors, [D-Arg1,D-Trp7,9, Leu11]substance P and [D-Pro4,D-Trp7,9,10]substance P-(4-11), inhibited hBRS-3 receptor activation...
  42. ncbi Receptor-activated currents in mouse fibroblasts expressing transfected bombesin receptor subtype cDNAs
    K Kusano
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    Am J Physiol 265:C869-76. 1993
    ..N-acetyl-GRP-(20-26) amide, [Leu13-psi(CH2NH)-Leu14]Bn, and [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P also blocked GRP Rt responses but at higher concentrations (10(-5) M)...
  43. pmc Innate immune responses and permissiveness to ranavirus infection of peritoneal leukocytes in the frog Xenopus laevis
    Heidi D Morales
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Virol 84:4912-22. 2010
    ..FV3 infection also induces a rapid upregulation of proinflammatory genes including arginase 1, interleukin-1beta, and tumor necrosis factor alpha...
  44. ncbi Intracellular signaling pathway of substance P-induced superoxide production in human neutrophils
    T Tanabe
    Department of Pharmacology, Kansai Medical University, Osaka, Japan
    Eur J Pharmacol 299:187-95. 1996
    ..by tachykinin NK1 receptor antagonists, [D- Pro9[spiro-gamma-lactam],Leu10,Trp11]physalaemin-(1-11) (GR82334) or [D-Arg1,D-Trp7,9,Leu11]substance P (spantide), and an intracellular Ca2+ chelator, 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-..
  45. doi Genetic variation in the urea cycle: a model resource for investigating key candidate genes for common diseases
    Sabrina Mitchell
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Hum Mutat 30:56-60. 2009
    ..ornithine transcarbamylase (OTC), argininosuccinate synthetase (ASS1), argininosuccinate lyase (ASL), and arginase 1 (ARG1)...
  46. ncbi Effect of tachykinins on the acetylcholine output stimulated by nicotine from guinea-pig bladder
    M Shinkai
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan
    Regul Pept 46:399-401. 1993
    ..A sympathetic nerve blocker guanethidine and tachykinin antagonist, [D-Arg1,D-Pro2,D-Trp7,9,Leu11]-substance P (rpwwL-SP) partially inhibited the acetylcholine release evoked by nicotine to ..
  47. ncbi Clinical consequences of urea cycle enzyme deficiencies and potential links to arginine and nitric oxide metabolism
    Fernando Scaglia
    Department of Molecular and Human Genetics, Children s Nutritional Research Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Nutr 134:2775S-2782S; discussion 2796S-2797S. 2004
    ..In contrast, hyperargininemia found in patients with arginase 1 deficiency is associated with pyramidal tract findings and spasticity, without significant hyperammonemia...
  48. pmc Persistent Coxiella burnetii infection in mice overexpressing IL-10: an efficient model for chronic Q fever pathogenesis
    Soraya Meghari
    Unite des Rickettsies, CNRS UMR 6020, Institut Federatif de Recherche 48, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
    PLoS Pathog 4:e23. 2008
    ..To our knowledge, this is the first efficient model for chronic Q fever pathogenesis...
  49. doi Coxiella burnetii, the agent of Q fever, stimulates an atypical M2 activation program in human macrophages
    Marie Benoit
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
    Eur J Immunol 38:1065-70. 2008
    ..Our results suggest that C. burnetii stimulated an atypical M2 activation program that may account for the persistence of C. burnetii in macrophages...
  50. doi Differential response of antigen presenting cells from susceptible and resistant strains of mice to Taenia crassiceps infection
    Jose L Reyes
    Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Mexico
    Infect Genet Evol 9:1115-27. 2009
    ..crassiceps infection is a possible mechanism that underlies the differential susceptibility to T. crassiceps infection displayed by these mouse strains...
  51. ncbi Functional annotation of the putative orphan Caenorhabditis elegans G-protein-coupled receptor C10C6.2 as a FLP15 peptide receptor
    Teresa M Kubiak
    Animal Health Discovery Research, Pharmacia Corporation, Kalamazoo, MI 49001, USA
    J Biol Chem 278:42115-20. 2003
    ..FLP15-R was activated by putative FLP15 peptides, GGPQGPLRF-NH2 (FLP15-1), RGPSGPLRF-NH2 (FLP15-2A), its des-Arg1 counterpart, GPSGPLRF-NH2 (FLP15-2B), and to a lesser extent, by a tobacco hornworm Manduca sexta FaRP, GNSFLRFNH2 (..
  52. ncbi Genetic approach to prenatal diagnosis in urea cycle defects
    Johannes Haberle
    Universitatsklinikum Munster, Klinik und Poliklinik für Kinderheilkunde, Munster, Germany
    Prenat Diagn 24:378-83. 2004
    ..To demonstrate the feasibility of prenatal diagnosis by molecular genetics in all urea cycle defects in order to improve and standardize the current approaches...
  53. doi Transcriptional profiling of the injured sciatic nerve of mice carrying the Wld(S) mutant gene: identification of genes involved in neuroprotection, neuroinflammation, and nerve regeneration
    Benoit Barrette
    Laboratory of Endocrinology and Genomics, Department of Molecular Medicine, Universite Laval, CHUL Research Center, Quebec, Canada
    Brain Behav Immun 24:1254-67. 2010
    ..processes and plasticity (Chl1, Epha5, Gadd45b, Jun, Nav2, Nptx1, Nrcam, Ntm, Sema4f), inflammation and immunity (Arg1, Lgals3, Megf10, Panx1), growth factors/cytokines and their receptors (Clcf1, Fgf5, Gdnf, Gfrα1, Il7r, Lif, Ngfr/..
  54. ncbi Intrathecal oxymetazoline does not produce neurotoxicity in the spinal cord of the rat
    C W Loomis
    School of Pharmacy, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
    Brain Res 599:73-82. 1992
    ..t. saline or 100 nmol OXY twice daily for 3 days, or 200 or 300 nmol OXY once daily for 3 days. Spantide (D-Arg1, D-Try7,9, Leu11-substance P; 0.067 nmol = 0.1 microgram, 0.167 nmol = 0.25 microgram or 0.334 nmol = 0...
  55. pmc In vitro effects of substance P analogue [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P on human tumour and normal cell growth
    M J Everard
    Section of Medicine, Royal Marsden Hospital, Belmont, Surrey, UK
    Br J Cancer 65:388-92. 1992
    ..We found [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P (D-Phe5SP) significantly inhibited DNA synthesis by 10/10 human tumour CLs; ..
  56. ncbi Stabilized analogs of thymopentin. 2. 1,2- and 3,4-ketomethylene pseudopeptides
    J I DeGraw
    Bio organic Chemistry Laboratory, SRI International, Menlo Park, California 94025, USA
    J Med Chem 40:2398-406. 1997
    In this second paper in a series of three studies of stable analogs of thymopentin (Arg1-Lys2-Asp3-Val4-Tyr5), the synthesis of analogs stabilized at peptide bonds 1,2 and 3,4 via insertion of ketomethylene units is described...
  57. ncbi Molecular basis of hyperargininemia: structure-function consequences of mutations in human liver arginase
    D E Ash
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Mol Genet Metab 64:243-9. 1998
    Hyperargininemia is a rare autosomal recessive disorder that results from a deficiency of hepatic type I arginase. At the genetic level, this deficiency in arginase activity is a consequence of random point mutations throughout the gene ..
  58. pmc ALTERED RESPONSE TO GRAVITY is a peripheral membrane protein that modulates gravity-induced cytoplasmic alkalinization and lateral auxin transport in plant statocytes
    Kanokporn Boonsirichai
    Laboratory of Genetics, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Plant Cell 15:2612-25. 2003
    b>ARG1 (ALTERED RESPONSE TO GRAVITY) is required for normal root and hypocotyl gravitropism...
  59. doi Mcm1p binding sites in the ARG1 promoter positively regulate ARG1 transcription and S. cerevisiae growth in the absence of arginine and Gcn4p
    Suntaek Hong
    Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Incheon, 406 840, Republic of Korea
    Amino Acids 40:623-31. 2011
    In this study, we investigated the activating role of Mcm1p at ARG1 during arginine starvation. Our results showed that two Mcm1p binding sites positively contribute to ARG1 transcription and cell growth...
  60. pmc Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children
    M T Salam
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Allergy 66:412-9. 2011
    ..oxide (NO) synthesis pathway, nitric oxide synthases (encoded by NOS1, NOS2A, and NOS3) and arginases (encoded by ARG1 and ARG2) compete for L-arginine...
  61. doi Biodegradable chitosan particles induce chemokine release and negligible arginase-1 activity compared to IL-4 in murine bone marrow-derived macrophages
    Jessica Guzmán-Morales
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, Canada
    Biochem Biophys Res Commun 405:538-44. 2011
    ....
  62. pmc Changes in transcriptional output of human peripheral blood mononuclear cells following resistance exercise
    Lara A Carlson
    Westbrook College of Health Professions, University of New England, 11 Hills Beach Road, Biddeford, ME 04005, USA
    Eur J Appl Physiol 111:2919-29. 2011
    ..of matrix metalloproteinase 9, orosomucoid 1, dishevelled-associated activator of morphogenesis 2, and arginase 1 suggest an induction in muscle damage and repair during this time frame...
  63. doi Molecular definition of the pro-tumorigenic phenotype of glioma-activated microglia
    Aleksandra Ellert-Miklaszewska
    Laboratory of Molecular Neurobiology, Neurobiology Center, The Nencki Institute of Experimental Biology, 3 Pasteur Str, Warsaw, Poland
    Glia 61:1178-90. 2013
    ..induction of genes coding for ID (inhibitor of DNA binding) 1/3 and c-Myc, markers of the alternative phenotype Arg1, MT1-MMP, CXCL14, and numerous cytokines/chemokines implicated in immune cell trafficking...
  64. doi Biotransformation of L-ornithine from L-arginine using whole-cell recombinant arginase
    Yueping Zhan
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing, 210093, China
    World J Microbiol Biotechnol 29:2167-72. 2013
    ..The gene ARG1 coding arginase from Bos taurus liver was synthesized and expressed in E. coli BL21 (DE3) via pETDuet-1...
  65. pmc The effect of 5'-adenylic acid on hepatic proteome of mice radiated by 60Co γ-ray
    Cuilin Cheng
    School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China
    Int J Mol Sci 15:186-202. 2013
    ..They were determined to be type I arginase, annexin A5, regucalcin, catalase, Tpm3 protein, Pdia4 protein, 14-3-3 protein epsilon, NAD-Malate ..
  66. pmc Protective role of 5-azacytidine on myocardial infarction is associated with modulation of macrophage phenotype and inhibition of fibrosis
    Yong Sook Kim
    Heart Research Center, Chonnam National University Hospital, Gwangju, South Korea
    J Cell Mol Med 18:1018-27. 2014
    ..5AZ exerts its cardiac protective role through modulation of macrophages and cardiac fibroblasts. ..
  67. ncbi [Significance of arginase-1, glypican-3, hepatocyte paraffin antigen 1 and alpha-fetoprotein in diagnosis and differential diagnosis of liver tumors]
    Jie Li
    Department of Pathology, General Hospital of PLA, Beijing 100853, China
    Zhonghua Bing Li Xue Za Zhi 43:246-50. 2014
    ....
  68. doi Arginase-1 is a more sensitive marker than HepPar-1 and AFP in differential diagnosis of hepatocellular carcinoma from nonhepatocellular carcinoma
    Wei Sang
    The Department of Pathology, the First Affiliated Hospital of Xinjiang Medical University, 137 South Liyushan Road, Urumqi, 830054, People s Republic of China
    Tumour Biol 36:3881-6. 2015
    ..3, 97.7, 87.0, and 87.1 % for AFP, respectively. Arg-1 is a more sensitive and better specific marker for HCC compared with HepPar-1 and AFP, indicating that Arg-1 can be easily applied in distinguishing HCC from metastatic tumors...
  69. pmc Critical Role of Mast Cells and Peroxisome Proliferator-Activated Receptor γ in the Induction of Myeloid-Derived Suppressor Cells by Marijuana Cannabidiol In Vivo
    Venkatesh L Hegde
    Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC 29209 and
    J Immunol 194:5211-22. 2015
    ..of CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSC) in the peritoneum, which expressed functional arginase 1, and potently suppressed T cell proliferation ex vivo...
  70. doi Treatment with Recombinant Trichinella spiralis Cathepsin B-like Protein Ameliorates Intestinal Ischemia/Reperfusion Injury in Mice by Promoting a Switch from M1 to M2 Macrophages
    Wei Feng Liu
    Department of Anesthesiology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    J Immunol 195:317-28. 2015
    ..These findings suggest that intestinal I/R injury causes a switch from M2 to M1 macrophages and that rTsCPB ameliorates intestinal injury by promoting STAT6-dependent M1 to M2 transition. ..
  71. pmc Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels
    Harmen H M Draisma
    1 Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, Amsterdam 1081 BT, The Netherlands 2 The EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands 3 Neuroscience Campus Amsterdam, De Boelelaan 1085, Amsterdam 1081 HV, The Netherlands
    Nat Commun 6:7208. 2015
    ..The novel SNPs are located in or near genes encoding metabolite transporter proteins or enzymes (SLC22A16, ARG1, AGPS and ACSL1) that have demonstrated biomedical or pharmaceutical importance...
  72. pmc Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood
    Ralph Burkhardt
    LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    PLoS Genet 11:e1005510. 2015
    ..and metabolite levels, we provide evidence for putative causative genes: SLC22A16 for total acylcarnitines, ARG1 for arginine, HLCS for 2-hydroxyisovalerylcarnitine, JAM3 for stearoylcarnitine via a trans-effect at chromosome 1, ..
  73. pmc IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production
    Yinpu Yue
    Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, P R China
    PLoS ONE 10:e0142979. 2015
    ..Gene expression analysis revealed that overexpression of IL4I1 drove the expression of M2 markers (Fizz1, Arg1, YM-1, MR) and inhibited the expression of M1-associated cytokines...
  74. pmc Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1
    Wen Zhu
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Carcinogenesis 37:839-51. 2016
    ..NHE1 upregulation is a novel marker of the glioma-associated microglial activation phenotype. Inhibition of NHE1 represents a novel glioma therapeutic strategy by targeting tumor-induced microglial activation. ..
  75. doi Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke
    Sighild Lemarchant
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, Biocenter Kuopio University of Eastern Finland, Kuopio, P O Box 1627, Finland
    Glia 64:1492-507. 2016
    ..By having anti-inflammatory and neuroregenerative roles, ADAMTS-4 may represent an interesting target to treat acute CNS injuries, such as ischemic stroke, SCI or traumatic brain injury. GLIA 2016;64:1492-1507. ..
  76. ncbi Electrostatic Interactions at N- and C-Termini Determine Fibril Polymorphism in Serum Amyloid A Fragments
    Justine M Jannone
    Department of Chemistry and Biochemistry, California Polytechnic State University San Luis Obispo, California 93407 United States
    J Phys Chem B 120:10258-10268. 2016
    ..in which C-terminal extension changes the favored intermolecular interaction between peptide monomers from an Arg1-C-terminus charge pair to an N-terminus-C-terminus charge pair...
  77. pmc Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets
    Wen Xing Li
    Institute of Health Sciences, Anhui University, Hefei, Anhui, China State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
    Peerj 4:e2470. 2016
    ..In addition, we found ARG1 and MMP9 were up-regulated in total and all subgroups...
  78. pmc Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages
    Hideyuki Takahashi
    Department of Otolaryngology Head and Neck Surgery, Gunma University Graduate School of Medicine, Gunma, Japan
    Oncotarget . 2016
    ..The gene expression level of ARG1, IL10, and TGFB1 was increased in CAF-educated cells...
  79. doi Mature CD10+ and immature CD10- neutrophils present in G-CSF-treated donors display opposite effects on T cells
    Olivia Marini
    Department of Medicine, Division of General Pathology, University of Verona, Verona, Italy
    Blood . 2017
    ..These neutrophils inhibit proliferation and IFNγ production by T cells via a CD18-mediated contact-dependent arginase 1 release...
  80. pmc The ARG1-LIKE2 gene of Arabidopsis functions in a gravity signal transduction pathway that is genetically distinct from the PGM pathway
    Changhui Guan
    Laboratory of Genetics, University of Wisconsin, 445 Henry Mall, Madison, WI 53706, USA
    Plant Physiol 133:100-12. 2003
    ..The ARL2 gene encodes a DnaJ-like protein similar to ARG1, another protein previously implicated in gravity signal transduction in Arabidopsis seedlings...
  81. ncbi Roles of brain angiotensins II and III in thirst and sodium appetite
    Wendy L Wilson
    Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
    Brain Res 1060:108-17. 2005
    ..The analogs, [D-Asp1D-Arg2]AngII and [D-Arg1]AngIII, were further protected from degradation by pretreatment with the aminopeptidase A inhibitor, EC33, or the ..
  82. ncbi Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor
    Birgitte Holst
    Laboratory for Molecular Pharmacology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen, Denmark
    Mol Pharmacol 70:936-46. 2006
    D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P functions as a low-potency antagonist but a high-potency full inverse agonist on the ghrelin receptor...
  83. ncbi IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans
    Uwe Muller
    Institute of Immunology, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany
    J Immunol 179:5367-77. 2007
    ..This indicates that IL-13 contributes to fatal allergic inflammation during C. neoformans infection...
  84. doi The CD20 homolog Ms4a8a integrates pro- and anti-inflammatory signals in novel M2-like macrophages and is expressed in parasite infection
    Astrid Schmieder
    Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Eur J Immunol 42:2971-82. 2012
    ..Ms4a8a(+) BMDMs were characterized by strong expression of mRNA of mannose receptor (Mmr), arginase 1, and CD163, and by decreased iNOS expression...
  85. pmc Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat
    T Cao
    Department of Biology, College of Art and Science, University of Kentucky, Lexington, KY, USA
    Neuroscience 225:65-75. 2012
    ..p.) significantly reduced the expression of these genes. Evidence for alternative activation (arginase 1) was not observed...
  86. pmc Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages
    Balázs Koscsó
    1 Rutgers New Jersey Medical School, 185 South Orange Ave, University Heights, Newark, NJ 07103, USA
    J Leukoc Biol 94:1309-15. 2013
    ..In conclusion, adenosine enhances IL-10-induced STAT3 signaling and M2c macrophage activation. ..
  87. pmc CXCR3 deficiency enhances tumor progression by promoting macrophage M2 polarization in a murine breast cancer model
    Steve Oghumu
    Department of Pathology, The Ohio State University Medical Center, Columbus, OH, USA Department of Oral Biology, The Ohio State University College of Dentistry, Columbus, OH, USA
    Immunology 143:109-19. 2014
    ..Targeting CXCR3 could be a potential therapeutic approach in the management of breast cancer tumors. ..
  88. doi Treatment of arginase deficiency revisited: guanidinoacetate as a therapeutic target and biomarker for therapeutic monitoring
    Wajdi Amayreh
    Department of Paediatrics, Clinic for Paediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany
    Dev Med Child Neurol 56:1021-4. 2014
    ..Measurement of guanidinoacetate and other guanidino compounds may, therefore, be important for therapeutic monitoring in arginase deficiency...
  89. doi γδT cells drive myeloid-derived suppressor cell-mediated CD8+ T cell exhaustion in hepatitis B virus-induced immunotolerance
    Xiaohui Kong
    Department of Immunology, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China
    J Immunol 193:1645-53. 2014
    ..Overall, the current study reveals that γδT cells play a previously unrecognized regulatory role in liver tolerance by mobilizing MDSC infiltration to the liver, leading to MDSC-mediated CD8(+) T cell exhaustion. ..
  90. pmc Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy
    Gloria Cantero
    Departments of Surgery
    J Neurosci 36:6680-90. 2016
    b>Arginase 1 deficiency is a urea cycle disorder associated with hyperargininemia, spastic diplegia, loss of ambulation, intellectual disability, and seizures...
  91. ncbi Tachykinins and calcitonin gene-related peptide enhance release of endogenous glutamate and aspartate from the rat spinal dorsal horn slice
    I Kangrga
    Department of Veterinary Physiology and Pharmacology, Iowa State University 50011
    J Neurosci 10:2026-38. 1990
    ..The SP-induced increase of Glu persisted in the absence of external Ca2+, but the effect was blocked by (D-Arg1, D-Pro2, D-Trp7,9, Leu11)-SP, an SP analog claimed to be an antagonist of the synthetic SP...
  92. ncbi Role of Ca2+ in the secretory and biosynthetic response of porcine gonadotropes to substance P and gonadotropin-releasing hormone
    Carmen Hidalgo-Díaz
    Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Campus Universitario de Rabanales, Edificio Severo Ochoa, Planta 3, E 14071, Cordoba, Spain
    Regul Pept 116:43-52. 2003
    ..The substance P antagonist D-Arg1,D-Phe5,-Trp7,9,Leu11-substance P (100 nM) blocked the stimulatory effect of substance P on LH release and its ..
  93. ncbi Elevated plasma arginase-1 does not affect plasma arginine in patients undergoing liver resection
    Marcel C G van de Poll
    Department of Surgery, University Hospital Maastricht and Nutrition and Toxicology Research Institute NUTRIM, Maastricht University, 6200 Maastricht, The Netherlands
    Clin Sci (Lond) 114:231-41. 2008
    ..In contrast with commonly held views, moderately increased arginase-1 plasma levels do not affect plasma arginine. Very high plasma arginase-1 levels are required to induce potential clinically relevant effects...
  94. doi Mammary tumor heterogeneity in the expansion of myeloid-derived suppressor cells
    Moses K Donkor
    Laboratory of Transplantation Immunology, Department of Pathology and Microbiology, 987660 Nebraska Medical Center, Omaha, NE 68198 7660, USA
    Int Immunopharmacol 9:937-48. 2009
    ..MDSCs are also directly associated with VEGF-A and G-CSF transcript levels suggesting multiple mechanisms for MDSC regulation and COX-2, NOS-2 and ARG-1 supporting multiple mechanisms of T-cell suppression...
  95. doi AT(1) receptor activation regulates the mRNA expression of CAT1, CAT2, arginase-1, and DDAH2 in preglomerular vessels from angiotensin II hypertensive rats
    Michael Hultström
    Renal Research Group, Department of Internal Medicine, Haukeland University Hospital, 5021 Bergen, Norway
    Am J Physiol Renal Physiol 297:F163-8. 2009
    ..In conclusion, CAT1, CAT2, DDAH2, and arginase-1 expression in renal resistance vessels is regulated through the AT(1) receptor. This finding may be of direct importance for NOS and the regulation of preglomerular vascular function...
  96. doi Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease
    Ana I Rojo
    Centro de Investigación en Red sobre Enfermedades Neurodegenerativas, Spain
    Glia 58:588-98. 2010
    ..This study demonstrates a crucial role of Nrf2 in modulation of microglial dynamics and identifies Nrf2 as molecular target to control microglial function in Parkinson's disease (PD) progression...
  97. pmc The nutrigenetics of hyperhomocysteinemia: quantitative proteomics reveals differences in the methionine cycle enzymes of gene-induced versus diet-induced hyperhomocysteinemia
    Patricia M DiBello
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Mol Cell Proteomics 9:471-85. 2010
    ..Several urea cycle proteins increased in both diet groups; however, arginase 1 decreased in the CBS(+/-) mice fed the control diet...
  98. pmc Azithromycin alters macrophage phenotype and pulmonary compartmentalization during lung infection with Pseudomonas
    David J Feola
    Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, KY 43536 0082, USA
    Antimicrob Agents Chemother 54:2437-47. 2010
    ..induced by azithromycin treatment, including the surface expression of the mannose receptor, the upregulation of arginase 1, and a decrease in the production of proinflammatory cytokines...
  99. pmc Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages
    Deepti R Nagarkar
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 185:2525-35. 2010
    ..These data provide a new paradigm to explain RV-induced asthma exacerbations...
  100. doi Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice
    Eric C Cheon
    Department of Surgery, Mount Sinai Hospital, University of Illinois College of Medicine, Chicago, Illinois, USA
    Cancer Res 71:1627-36. 2011
    ..Together, our results establish a pro-tumorigenic role of hematopoietic 5LO in the immune microenvironment and suggest 5LO inhibition as an avenue for future investigation in treatment of colorectal polyposis and cancer...
  101. pmc Distinct macrophage phenotypes contribute to kidney injury and repair
    Sik Lee
    Yale University School of Medicine, 333 Cedar Street, PO Box 208029, New Haven, CT 06510, USA
    J Am Soc Nephrol 22:317-26. 2011
    ..M1) macrophages are recruited into the kidney in the first 48 hours after ischemia/reperfusion injury, whereas arginase 1- and mannose receptor-positive, noninflammatory (M2) macrophages predominate at later time points...

Research Grants47

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Keith T Wilson; Fiscal Year: 2016
    ..nitric oxide (NO) synthase (iNOS), that generates high output NO;and arginase, consisting of two forms, arginase I (Arg1) and arginase II (Arg2) that generate L-ornithine, which is the substrate for polyamine synthesis by ornithine ..
  3. Keith T Wilson; Fiscal Year: 2016
    ..While inhibition of arginase or knockdown of arginase 1 (Arg1) prevented restitution, this could be completely restored, in the presence of L- Arg, when either L-Orn or ..
  4. Michal A Olszewski; Fiscal Year: 2016
    ..In unfavorable clinical circumstances, M become alternatively activated and induce Arginase (ARG1), an intracellular enzyme that consumes L-arginine but does not induce nitric oxide...
  5. ROBERT MATTHEW TIGHE; Fiscal Year: 2016
    ..Collectively, this approach will allow us to dissect the role of arginase-1 production by macrophages and fibroblasts in the pathobiology of progressive pulmonary fibrosis. ..
  6. NITRIC OXIDE AND OXYGENATION IN DIABETIC KIDNEYS
    NILS AXEL FREDRIK PALM; Fiscal Year: 2010
    ..abstract_text> ..
  7. Buddy Ullman; Fiscal Year: 2016
    ..donovani;and 3) Arg1 flox/flox;Tie2cre mice that lack ARG1 in macrophages and their Tie2cre Cre deleter controls...
  8. Role of TAM Arginase 1 in Tumor Progression
    Joseph E Qualls; Fiscal Year: 2011
    ..Increased expression of the urea cycle enzyme arginase 1 (Arg1) is closely correlated with TAMs...
  9. DAVID FEOLA; Fiscal Year: 2016
    ....
  10. Jeffrey A Kline; Fiscal Year: 2015
    ..if NO+O2 corrects defective platelet oxidative metabolism associated with PE, and reduces release of CF DNA/RNA coincident with reduced clotting time and strength on thromboelastography. ..
  11. Immature myeloid cells as targets for therapeutics to bacterial infection
    ADRIANUS WILHELMUS MARIA VAN DER VELDEN; Fiscal Year: 2013
    ..Typhimurium. In Specific Aim 3, we will specifically target MDSC expansion, activation and suppressive activity at the transition from innate to adaptive immune response as a novel therapeutic approach to infection. ..
  12. Jun Xu; Fiscal Year: 2015
    ..HM) from the model reveals heightened induction of M1 Nos2 gene over moderate induction of M2 arginase-1 (Arg1) gene as a plausible cause of the nitrosative stress...
  13. Ruth B Caldwell; Fiscal Year: 2016
    ..Furthermore, the cytosolic isoform arginase 1 (A1) is implicated in premature senescence and dysfunction of vascular endothelial cells (EC), whereas the ..
  14. Augusto C Ochoa; Fiscal Year: 2016
    ..The depletion of the amino acids arginine or tryptophan by the enzymes arginase 1 (Ase-1) and indoleamine 2,3- dioxygenase (IDO) is one of the mechanisms by which the immune system regulates the ..
  15. Yi Zhang; Fiscal Year: 2016
    ..higher levels of CD80 and CD86, had increased IL6 and IL23 mRNA but reduced transcripts of IL12, IL21 and Arginase 1. Inhibition of Dll4 caused a reduction in frequency of alloreactive effector T cells activated by allogeneic DCs...
  16. Nicholas J Kenyon; Fiscal Year: 2016
    ..therapy and that these patients will have a lower exhaled NO concentrations (<20 ppb) and a higher NOS2/Arg1 mRNA and protein ratio in their airway epithelial cells than "non-responders...
  17. The role of myeloid suppressor cells in tumor-specific tolerance
    Ivan M Borrello; Fiscal Year: 2011
    ..Lastly, we will attempt to develop strategies to reduce MSC function in the transplant setting through the use of Viagra and related drugs based on our recent observations that these drugs can effectively inhibit MSC function. ..
  18. STRUCTURAL AND MECHANISTIC ANALYSIS OF LIVER ARGINASE
    David Ash; Fiscal Year: 2001
    ..In liver, this reaction is catalyzed by type I arginase and constitutes the final step of the urea cycle...
  19. STRUCTURAL AND MECHANISTIC ANALYSIS OF LIVER ARGINASE
    David Ash; Fiscal Year: 2005
    ..In liver, this reaction is catalyzed by type I arginase and constitutes the final step of the urea cycle...
  20. Kevin B Urdahl; Fiscal Year: 2016
    ..The challenge of early life vaccination lies in the limitations of the infant immune response. Thus, it is pertinent to elucidate the mechanisms behind reduced neonatal immunity to illuminate ways to enhance infant immune responses. ..
  21. Immature Myeloid Cells and T Cell Suppression in Trauma
    Juan Ochoa; Fiscal Year: 2009
    ..TIIMC also express very high levels of arginase 1 (ARG1) and possibly the cationic aminoacid transporter Cat2b and therefore appear to deplete arginine, an amino ..
  22. NITRIC OXIDE AND OXYGENATION IN DIABETIC KIDNEYS
    NILS PALM; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  23. Lloyd G Cantley; Fiscal Year: 2016
    ..from injured kidneys at the time of M1-M2 transition reveals >100-fold increase in expression of two proteins, Arg1 and Brp39, both of which are strongly implicated in promoting tubular cell survival and proliferation...
  24. MECHANISMS OF AIRFLOW OBSTRUCTION
    Julian Solway; Fiscal Year: 1992
    ..vs respiratory resistance dose-response curves, before and after administration of chlorpheniramine, LY171883, (D-Arg1,D- Pro2,D-Trp7,9,Leu11) substance P, thiorphan and/or captopril, or atropine, or obtain hyperpnea dose-response ..
  25. James L Manley; Fiscal Year: 2014
    ..At the induced ARG1 gene, sumoylation facilitates clearance of promoter-bound factors, enabling it to be shut off...
  26. SYNTHESIS AND CONFORMATION OF PEPTIDE HORMONES
    Murray Goodman; Fiscal Year: 2003
    ..analogs with high potency and high selectivity at hsst3 (Pro1-c[Cys2-Phe -D-Trp4-Lys4-Val6-Cys7]-NH2- and hsst5 (Arg1-c[Cys2 -Tyr3 -D-Trp4-Lys5-Val6Cys7] -Lys8-NH2)...
  27. Molecular Mechanisms of Cardiac Arrhythmias
    Qing Wang; Fiscal Year: 2005
    ..These studies may provide a new framework for the rational design of therapeutic agents. ..
  28. Improved actions of nitrates and statins with L-arginine
    Ruth Caldwell; Fiscal Year: 2003
    ..3. Develop an IV formulation of GTN in combination with L-arginine and an oral combined sustained release formulation of ISMN and L-arginine. 4. Develop an oral combined sustained release formulation of SIM and L-arginine. ..
  29. PATHOGENESIS OF FILAMENTOUS INFLUENZA VIRUS INFECTION
    Paul Roberts; Fiscal Year: 2003
    ..These studies will set the foundation for establishing further determinants of influenza virus pathogenesis and severity of disease in humans. ..
  30. HELPER T CELL SUBSETS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 2005
    ..The use of a parasite model in which the outcome has been so clearly tied to this decision offers an opportunity for important insights into disease susceptibility and effective vaccine strategy. ..
  31. Role of the Snf1 protein kinase in regulating eukaryotic gene expression
    Karen Arndt; Fiscal Year: 2007
    ..The conservation between Snf1 and AMPK and between their potential targets strongly suggests that the proposed studies will provide new insights into the function of AMPK. [unreadable] [unreadable] [unreadable]..
  32. Regulation of Arginase Genes in Sepsis and Trauma
    Sidney Morris; Fiscal Year: 2005
    ..abstract_text> ..
  33. ALS-mutant SOD1-induced motor neuron apoptosis
    Alvaro Estevez; Fiscal Year: 2006
    ....
  34. Immunobiology of Lung Fibrosis
    Ana Mora; Fiscal Year: 2007
    ..4. Using IL-4 receptor deficient mice with and without adoptive transfer of normal Th2 cells, to determine whether IL-4 signaling in cells other than T lymphocytes is important to the lung fibrogenic response to MHV68 or bleomycin. ..
  35. BLOOD-RETINAL BARRIER CHANGES IN RETINOPATHY
    Ruth B Caldwell; Fiscal Year: 2010
    ..These studies will set the stage for developing therapies for targeting both neural and vascular pathology and preventing diabetic retinopathy, the leading cause of blindness in working age adults in the US today. ..
  36. Gene by Environment Interactions in Asthma and Allergy
    Augusto Litonjua; Fiscal Year: 2009
    ..Blood for genetic material is currently being collected on the two cohorts, and endotoxin will be measured from stored, frozen house dust. ..
  37. The Role of Triggering Receptor Expressed on Myeloid Cells-2 (Trem2) on Microglia
    Christine Hsieh; Fiscal Year: 2008
    ..The significance of understanding the role of TREM2 may be applied to multiple neurological and immunological diseases. [unreadable] [unreadable]..
  38. Avian Influenza Virus Vaccines Bearing Immunomodulators
    Paul Roberts; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  39. FILAMENTOUS INFLUENZA VIRUS AND MICROBIAL COLONIZATION
    Paul Roberts; Fiscal Year: 2004
    ..In parallel, we will also determine whether prior bacterial colonization can affect influenza virus replication in respiratory epithelium. ..
  40. Molecular Determinants of Coronary Artery Disease
    Qing Wang; Fiscal Year: 2004
    ..The accomplishment of research objectives in this proposal has the potential to have a substantial impact on the understanding of the molecular mechanism of CAD and MI, thereby facilitating better prevention, diagnosis and therapy. ..
  41. Vitamin D in Obstructive Lung Diseases
    Augusto Litonjua; Fiscal Year: 2008
    ..Additionally, supplementation with vitamin D can be implemented in cost-effective population-based programs to prevent the development of, and treat these disorders. [unreadable] [unreadable] [unreadable]..
  42. TRANSCRIPTION FACTOR MUTANTS OF YEAST
    Karen Arndt; Fiscal Year: 2004
    ..abstract_text> ..
  43. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
    ..abstract_text> ..
  44. GENES FOR VASCULAR MORPHOGENESIS: A GENETIC APPROACH
    Qing Wang; Fiscal Year: 2003
    ..Moreover, understanding the genetic mechanisms underlying KTS offers possibilities for treatment of KTS as well as conditions such as cancer that depend on angiogenesis. ..
  45. IMMUNE DYSFUNCTION AND IMMUNOTHERAPY OF RENAL CANCER
    Augusto Ochoa; Fiscal Year: 2003
    ....
  46. Longitudinal Lung Function Changes--Aging/Genetics/Risk
    Augusto Litonjua; Fiscal Year: 2008
    ..The results of this proposal will shed light on potential mechanisms that affect lung function decline in aging. ..
  47. BETA-2 ADRENERGIC RECEPTOR POLYMORPHISMS AND ASTHMA
    Augusto Litonjua; Fiscal Year: 2002
    ..End of Abstract) ..