apolipoprotein D

Summary

Gene Symbol: apolipoprotein D
Description: apolipoprotein D
Alias: apolipoprotein D, apo-D
Species: human

Top Publications

  1. ncbi Is apolipoprotein D a mammalian bilin-binding protein?
    M C Peitsch
    Laboratory of Mathematical Biology, National Cancer Institute, Frederick, MD 21701
    New Biol 2:197-206. 1990
  2. pmc Apolipoprotein D is the major protein component in cyst fluid from women with human breast gross cystic disease
    M Balbin
    Departamento de Biologia Funcional, Facultad de Medicina, Universidad de Oviedo, Spain
    Biochem J 271:803-7. 1990
  3. ncbi Cloning and expression of human apolipoprotein D cDNA
    D Drayna
    J Biol Chem 261:16535-9. 1986
  4. pmc A cholesteryl ester transfer complex in human plasma
    P E Fielding
    Proc Natl Acad Sci U S A 77:3327-30. 1980
  5. pmc Site-specific detection and structural characterization of the glycosylation of human plasma proteins lecithin:cholesterol acyltransferase and apolipoprotein D using HPLC/electrospray mass spectrometry and sequential glycosidase digestion
    P A Schindler
    Department of Pharmaceutical Chemistry, University of California, San Francisco 94143, USA
    Protein Sci 4:791-803. 1995
  6. ncbi Apolipoprotein D
    E Rassart
    Departement des Sciences Biologiques, Universite du Quebec a Montreal, Canada
    Biochim Biophys Acta 1482:185-98. 2000
  7. ncbi Expression pattern of the lipocalin apolipoprotein D during mouse embryogenesis
    Diego Sanchez
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, E 03550 Alicante, Spain
    Mech Dev 110:225-9. 2002
  8. ncbi Genetic variation in the apolipoprotein D gene among African blacks and its significance in lipid metabolism
    Purnima P Desai
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, PA 15261, USA
    Atherosclerosis 163:329-38. 2002
  9. ncbi Genetic variation in apolipoprotein D affects the risk of Alzheimer disease in African-Americans
    Purnima P Desai
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet B Neuropsychiatr Genet 116:98-101. 2003
  10. ncbi Senescence-associated genes in normal human oral keratinocytes
    Mo K Kang
    School of Dentistry and Dental Research Institute, University of California, Los Angeles, CA 90095, USA
    Exp Cell Res 287:272-81. 2003

Research Grants

Scientific Experts

Detail Information

Publications173 found, 100 shown here

  1. ncbi Is apolipoprotein D a mammalian bilin-binding protein?
    M C Peitsch
    Laboratory of Mathematical Biology, National Cancer Institute, Frederick, MD 21701
    New Biol 2:197-206. 1990
    Human apolipoprotein D (APO-D) is a serum glycoprotein that has no sequence similarity with other apolipoproteins but rather belongs to the alpha 2-microglobulin superfamily whose other members transport small hydrophobic ligands in a ..
  2. pmc Apolipoprotein D is the major protein component in cyst fluid from women with human breast gross cystic disease
    M Balbin
    Departamento de Biologia Funcional, Facultad de Medicina, Universidad de Oviedo, Spain
    Biochem J 271:803-7. 1990
    ..from protein GCDFP-24 matched perfectly with regions present in the amino acid sequence determined for human apolipoprotein D. Additional data on N-terminal sequence of the unblocked proteins, carbohydrate-attachment sites, amino acid ..
  3. ncbi Cloning and expression of human apolipoprotein D cDNA
    D Drayna
    J Biol Chem 261:16535-9. 1986
    The amino acid sequence of human apolipoprotein D, a component of high density lipoprotein, has been obtained from the cloned cDNA sequence...
  4. pmc A cholesteryl ester transfer complex in human plasma
    P E Fielding
    Proc Natl Acad Sci U S A 77:3327-30. 1980
    ..3.1.43) (LCAT) and transfer protein (apo D)...
  5. pmc Site-specific detection and structural characterization of the glycosylation of human plasma proteins lecithin:cholesterol acyltransferase and apolipoprotein D using HPLC/electrospray mass spectrometry and sequential glycosidase digestion
    P A Schindler
    Department of Pharmaceutical Chemistry, University of California, San Francisco 94143, USA
    Protein Sci 4:791-803. 1995
    ..The three additional glycopeptides were determined to be from a copurifying protein, apolipoprotein D, which contains potential N-linked glycosylation sites at Asn45 and Asn78...
  6. ncbi Apolipoprotein D
    E Rassart
    Departement des Sciences Biologiques, Universite du Quebec a Montreal, Canada
    Biochim Biophys Acta 1482:185-98. 2000
    b>Apolipoprotein D (apoD) is a 29-kDa glycoprotein that is primarily associated with high density lipoproteins in human plasma...
  7. ncbi Expression pattern of the lipocalin apolipoprotein D during mouse embryogenesis
    Diego Sanchez
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, E 03550 Alicante, Spain
    Mech Dev 110:225-9. 2002
    b>Apolipoprotein D (ApoD) is a secreted protein that belongs to the lipocalin family. We describe the expression pattern of ApoD during mouse embryogenesis by in situ hybridization using RNA probes...
  8. ncbi Genetic variation in the apolipoprotein D gene among African blacks and its significance in lipid metabolism
    Purnima P Desai
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, PA 15261, USA
    Atherosclerosis 163:329-38. 2002
    b>Apolipoprotein D (APOD, gene; apoD, protein) is a plasma high-density lipoprotein (HDL)-associated glycoprotein, with a putative role in the cholesterol (CHOL) transport pathway...
  9. ncbi Genetic variation in apolipoprotein D affects the risk of Alzheimer disease in African-Americans
    Purnima P Desai
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet B Neuropsychiatr Genet 116:98-101. 2003
    b>Apolipoprotein D (APOD, gene; apoD, protein) is involved in neuroregenerative and neurodegenerative processes, and is upregulated in late-onset Alzheimer disease (AD) patients compared to nondemented controls...
  10. ncbi Senescence-associated genes in normal human oral keratinocytes
    Mo K Kang
    School of Dentistry and Dental Research Institute, University of California, Los Angeles, CA 90095, USA
    Exp Cell Res 287:272-81. 2003
    ..These results indicate that the onset of senescence in NHOK is associated with altered expression of the SA genes, which represent discrete gene groups, independently of the donor variation or culture conditions...
  11. ncbi Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 54:136-41. 2003
    ..b>Apolipoprotein D (apoD) is elevated in association with several central nervous system disorders, including Alzheimer's ..
  12. ncbi Apolipoprotein D expression in human brain reactive astrocytes
    Eva Del Valle
    Departamento de Morfologia y Biologia Celular, Facultad de Biología y Medicina, Universidad de Oviedo, Espana
    J Histochem Cytochem 51:1285-90. 2003
    ..One of these biomolecules is apolipoprotein D (apo D), a member of the lipocalin family implicated in the transport of small hydrophobic molecules...
  13. ncbi Apolipoprotein D inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell proliferated by preventing translocation of phosphorylated extracellular signal regulated kinase 1/2 to the nucleus
    Jennifer M Sarjeant
    Cardiovascular Research Program, The Hospital for Sick Children, and the Department of Pediatrics, University of Toronto
    Arterioscler Thromb Vasc Biol 23:2172-7. 2003
    Elevated apolipoprotein D (apoD) levels are associated with reduced proliferation of cancer cells...
  14. ncbi Genetic variation in apolipoprotein D and Alzheimer's disease
    Seppo Helisalmi
    Dept of Neuroscience and Neurology, University Hospital and University of Kuopio, Kuopio, Finland
    J Neurol 251:951-7. 2004
    b>Apolipoprotein D (apoD) is a lipoprotein-associated glycoprotein, structurally unrelated to apoE, that transports small hydrophobic ligands including cholesterol and sterols...
  15. ncbi Apolipoprotein D expression in substantia nigra of Parkinson disease
    C Ordonez
    Department of Morphology and Cellular Biology, Faculty of Biology and Medicine, University of Oviedo, Oviedo, Spain
    Histol Histopathol 21:361-6. 2006
    b>Apolipoprotein D (apo D), a lipocalin transporter of small hydrophobic molecules could play an important role in several neurodegenerative diseases. However, its role in those diseases remains unclear...
  16. pmc Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila
    Julien Muffat
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 105:7088-93. 2008
    b>Apolipoprotein D (ApoD) expression increases in several neurological disorders and in spinal cord injury...
  17. doi Association between polymorphisms in the apolipoprotein D gene and sporadic Alzheimer's disease
    Yan Chen
    Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing 100053, China
    Brain Res 1233:196-202. 2008
    b>Apolipoprotein D (apoD) is a lipoprotein-associated glycoprotein that is increased in the hippocampus and cerebrospinal fluid of patients with Alzheimer's disease (AD), which implies that apoD might be involved in the pathogenesis of AD...
  18. doi Neuroprotective effect of apolipoprotein D against human coronavirus OC43-induced encephalitis in mice
    Sonia Do Carmo
    Laboratoire de Biologie Moleculaire, Departement des Sciences Biologiques, and BioMed, Centre de Recherches Biomédicales, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    J Neurosci 28:10330-8. 2008
    b>Apolipoprotein D (apoD) is a lipocalin upregulated in the nervous system after injury or pathologies such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis...
  19. doi Human apolipoprotein D overexpression in transgenic mice induces insulin resistance and alters lipid metabolism
    Sonia Do Carmo
    Departement des Sciences Biologiques, Universite du Quebec a Montreal, Case Postale 8888, Succursale Centre Ville, Montreal, Quebec, H3C 3P8 Canada
    Am J Physiol Endocrinol Metab 296:E802-11. 2009
    b>Apolipoprotein D (apoD), a widely expressed lipocalin, has the capacity to transport small hydrophobic molecules...
  20. doi Apolipoprotein-D expression is increased during development and maturation of the human prefrontal cortex
    Woojin S Kim
    Prince of Wales Medical Research Institute, Randwick, New South Wales, Australia
    J Neurochem 109:1053-66. 2009
    b>Apolipoprotein D (apoD) is a lipid binding protein expressed in the brain where its function is largely unknown...
  21. pmc Apolipoprotein D: An overview of its role in aging and age-related diseases
    Julien Muffat
    Division of Biology, California Institute of Technology, Pasadena, CA, USA
    Cell Cycle 9:269-73. 2010
    ..It's got to be doing something important!"-Seymour Benzer, reflecting on the observation that ApoD mRNA levels increase 500-fold following neuronal crush injury...
  22. doi Expression and potential role of apolipoprotein D on the death-survival balance of human colorectal cancer cells under oxidative stress conditions
    Raquel Bajo-Grañeras
    Instituto de Biología y Genética Molecular Departamento de Bioquímica y Biología Molecular y Fisiología, Universidad de Valladolid CSIC, c Sanz y Forés 3, 47003, Valladolid, Spain
    Int J Colorectal Dis 28:751-66. 2013
    Inverse correlations of apolipoprotein D (ApoD) expression with tumor growth have been shown, therefore proposing ApoD as a good prognostic marker for diverse cancer types, including colorectal cancer (CRC)...
  23. pmc Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress
    Maria D Ganfornina
    Departamento de Bioquímica y Biología Molecular y Fisiología IBGM, Universidad de Valladolid CSIC, 47003 Valladolid, Spain
    Aging Cell 7:506-15. 2008
    Many nervous system pathologies are associated with increased levels of apolipoprotein D (ApoD), a lipocalin also expressed during normal development and aging...
  24. ncbi GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex
    M A Deeg
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Lipid Res 42:442-51. 2001
    ..Deeg, M. A., E. L. Bierman, and M. C. Cheung. GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex. J. Lipid Res. 2001. 42: 442--451...
  25. ncbi Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I
    J K Boyles
    Gladstone Foundation Laboratories for Cardiovascular Disease, Department of Pathology, University of California, San Francisco 94140 0608
    J Biol Chem 265:17805-15. 1990
    ..The results from this study provide evidence that several different apolipoproteins from various sources may play a role in lipid transport within neural tissues...
  26. ncbi Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis
    C J Carter
    Neurochem Int 50:12-38. 2007
    ..Am. J. Hum. Genet. 78, 464-479.]. Thus, the fact that Alzheimer's disease susceptibility genes converge on a clearly defined signaling network has important implications for genetic association studies...
  27. doi Co-expression of estrogen receptor alpha and Apolipoprotein D in node positive operable breast cancer--possible relevance for survival and effects of adjuvant tamoxifen in postmenopausal patients
    Håvard Søiland
    Department of Surgery, Stavanger University Hospital, Norway
    Acta Oncol 48:514-21. 2009
    ..ERalpha signaling normally down-regulates expression of Apolipoprotein D (ApoD), a lipocalin that binds, transports or chelates lipophilic ligands, including tamoxifen (TAM)...
  28. ncbi Cellular cholesterol storage in the Niemann-Pick disease type C mouse is associated with increased expression and defective processing of apolipoprotein D
    S Suresh
    Neurobiology Research Laboratory, VA Connecticut Healthcare System, Newington 06111, USA
    J Neurochem 70:242-51. 1998
    b>Apolipoprotein D (apoD), a member of the lipocalin superfamily of ligand transporters, has been implicated in the transport of several small hydrophobic molecules including sterols and steroid hormones...
  29. doi The N-terminal amino acid of apolipoprotein D is putatively covalently bound to 3-hydroxy-3-methyl hexanoic acid, a key odour compound in axillary sweat
    S Akiba
    Kao Corporation, Tochigi Research Labs, 2606 Akabane, Ichikai, Haga, Tochigi 321 3497, Japan
    Int J Cosmet Sci 33:283-6. 2011
    ..One report states that 3M2H linked non-covalently to apolipoprotein D (apoD) is the precursor, while a second report states that 3M2H-Gln identified in human axillary sweat is the ..
  30. ncbi Urinary excretion of apolipoprotein(a): relation to other plasma proteins
    K Kostner
    Department of Cardiology, University Hospital, AKH Vienna, Währingergürtel 18 20, A 1090 Vienna, Austria
    Clin Chim Acta 304:29-37. 2001
    ....
  31. pmc Differential gene expression profile in pig adipose tissue treated with/without clenbuterol
    Jin Zhang
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100094, China
    BMC Genomics 8:433. 2007
    ..The objective of this research is to identify novel genes and physiological pathways that potentially facilitate clenbuterol induced reduction of adipose accumulation...
  32. ncbi Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes
    I J Bujalska
    Division of Medical Sciences, The Medical School, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Mol Endocrinol 37:327-40. 2006
    ..Our results provide insight into the genes involved in the regulation of adipocyte differentiation by cortisol, highlighting the depot specifically in human adipose tissue...
  33. doi Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy
    Yasuhito Wakasaya
    Department of Neurology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Neurosci Res 89:576-84. 2011
    ..Among 24 altered genes, increased levels of apolipoprotein D (ApoD) and neuronal PAS domain protein 4 (Npas4) and decreased levels of doublecortin (DCX) and potassium ..
  34. doi Comparative proteomic profiling of plasma very-low-density and low-density lipoproteins
    Hung Yu Sun
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Clin Chim Acta 411:336-44. 2010
    ..Low-density lipoprotein (LDL) is a natural metabolite of very-low-density lipoprotein (VLDL) in the circulation. Systematic investigation of total protein components and dynamics might provide insights into this normal metabolic process...
  35. ncbi Molecular characterization and differential mRNA tissue distribution of rabbit apolipoprotein D
    P R Provost
    Departement des Sciences Biologiques, Universite du Quebec a Montreal, Canada
    J Lipid Res 31:2057-65. 1990
    We report for the first time the quantification of relative apolipoprotein D (apoD) mRNA concentrations in a wide selection of organs and a detailed characterization of the rabbit protein...
  36. ncbi Antipsychotic drugs differentially modulate apolipoprotein D in rat brain
    M M Khan
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, GA 30904, USA
    J Neurochem 86:1089-100. 2003
    ..The increased expression of apoD by atypical antipsychotics may reflect a novel molecular mechanism underlying their favorable effects compared with HAL on cognition, negative symptoms and extra-pyramidal symptoms in schizophrenia...
  37. ncbi Association of plasma apolipoproteins D with RBC membrane arachidonic acid levels in schizophrenia
    Jeffrey K Yao
    Neurochemistry and Psychopharmacology Laboratory Bldg 13, VA Pittsburgh Healthcare System, 7180 Highland Dr, Pittsburgh, PA 15206, USA
    Schizophr Res 72:259-66. 2005
    b>Apolipoprotein D (apoD) is a member of the lipocalin superfamily of transporter proteins that bind small hydrophobic molecules, including arachidonic acid (AA)...
  38. doi ApoD, a glia-derived apolipoprotein, is required for peripheral nerve functional integrity and a timely response to injury
    Maria D Ganfornina
    Instituto de Biología y Genética Molecular Departamento de Bioquímica y Biología Molecular y Fisiología, Universidad de Valladolid CSIC, Valladolid, Spain
    Glia 58:1320-34. 2010
    ..In this work we focus on Apolipoprotein D (ApoD), a Lipocalin expressed by glial cells in the PNS and CNS...
  39. ncbi Apolipoprotein D expression in retinoblastoma
    Maria L Alvarez
    Department of Ophthalmology, Hospital Alvarez Buylla, Aviles, Asturias, Spain
    Ophthalmic Res 35:111-6. 2003
    The presence of apolipoprotein D (apoD) synthesis in brain suggests that this protein could play a major role in mediating neuronal degeneration and regeneration in the central nervous system (CNS)...
  40. ncbi From pharmacotherapy to pathophysiology: emerging mechanisms of apolipoprotein D in psychiatric disorders
    E A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Curr Mol Med 3:408-18. 2003
    b>Apolipoprotein D (apoD) is an atypical plasma apolipoprotein and, based on its primary structure, it is a member of the lipocalin protein superfamily...
  41. ncbi Apolipoprotein D modulates arachidonic acid signaling in cultured cells: implications for psychiatric disorders
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, MB 10, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Prostaglandins Leukot Essent Fatty Acids 69:421-7. 2003
    ..AA is a primary binding ligand for apolipoprotein D (apoD), which is increased in response to antipsychotic drug treatment and elevated in subjects with ..
  42. ncbi Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan
    David W Walker
    Division of Biology, California Institute of Technology, Pasadena, 91125, USA
    Curr Biol 16:674-9. 2006
    Increased Apolipoprotein D (ApoD) expression has been reported in various neurological disorders, including Alzheimer's disease, schizophrenia, and stroke, and in the aging brain . However, whether ApoD is toxic or a defense is unknown...
  43. ncbi Loss of glial lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila
    Diego Sanchez
    Departamento de Bioquímica y Fisiología y Genética Molecular IBGM, Universidad de Valladolid CSIC, Spain
    Curr Biol 16:680-6. 2006
    The vertebrate Apolipoprotein D (ApoD) is a lipocalin secreted from subsets of neurons and glia during neural development and aging ...
  44. ncbi Identification of differentially expressed genes in the developing antler of red deer Cervus elaphus
    Andrea Molnár
    Institute of Genetics, Agricultural Biotechnology Center, Szent Györgyi A u 4, 2100, Godollo, Hungary
    Mol Genet Genomics 277:237-48. 2007
    ..genes that encode alpha-tropomyosine (tpm1), transgelin (tagln), annexin 2 (anxa2), phosphatidylethanolamine-binding protein (pebp) and apolipoprotein D (apoD) in intense but still controlled tissue proliferation are discussed.
  45. pmc Emerging concepts of apolipoprotein D with possible implications for breast cancer
    Håvard Søiland
    Department of Surgery, Stavanger University Hospital, Stavanger, University of Bergen, Norway
    Cell Oncol 29:195-209. 2007
    b>Apolipoprotein D (ApoD) is a small glycoprotein of 24 kD, and a member of the lipocalin family. ApoD exerts several intracellular mechanistic roles, especially ligand binding...
  46. pmc Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma
    F J Vizoso
    Unidad de Investigacion, Fundación Hospital de Jove, Gijon, and Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain
    World J Gastroenterol 13:3221-7. 2007
    To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible ..
  47. doi Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures
    J Kosacka
    Institute of Anatomy, University of Leipzig, Liebigstrabetae 13, D 04103 Leipzig, Germany
    Neuroscience 162:282-91. 2009
    ..We thus assume that apolipoprotein-induced neuritogenesis in DRG cells interferes with CXCR4 signaling, and that adipocyte-derived apolipoproteins might be helpful in nerve repair...
  48. pmc Meta-analysis of age-related gene expression profiles identifies common signatures of aging
    João Pedro de Magalhães
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Bioinformatics 25:875-81. 2009
    ....
  49. ncbi Molecular characterization and differential mRNA tissue distribution of mouse apolipoprotein D
    D Seguin
    Departement des Sciences Biologiques, Universite du Quebec a Montreal, Canada
    Brain Res Mol Brain Res 30:242-50. 1995
    The mouse apolipoprotein D gene was isolated from a brain cDNA library. The nucleotide sequence contains a unique reading frame coding for a protein sharing 79.5% homology with human apoD, 86.2% homology with rabbit apoD and 92...
  50. ncbi The murine gene encoding apolipoprotein D exhibits a unique expression pattern as compared to other species
    S Cofer
    Department of Biochemistry, University of Illinois at Chicago 60612, USA
    Gene 171:261-3. 1996
    The ApoD cDNA coding for murine apolipoprotein D (ApoD) was cloned from a mammary gland library and sequenced. The nucleotide sequence and encoded mature protein are highly homologous to those of rabbit and human...
  51. ncbi Increased levels of apolipoprotein D in cerebrospinal fluid and hippocampus of Alzheimer's patients
    L Terrisse
    Departement des Sciences Biologiques, Universite du Quebec a Montreal, Canada
    J Neurochem 71:1643-50. 1998
    b>Apolipoprotein D (apoD) is a member of the lipocalin family of proteins...
  52. ncbi The neurobiology of apolipoproteins in psychiatric disorders
    J Gregor Sutcliffe
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Mol Neurobiol 26:369-88. 2002
    ..Furthermore, the authors discuss the role of apoD in the pathology and pharmacotherapy of schizophrenia and bipolar disorder...
  53. ncbi Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer: genome-wide gene-expression profiles of prostate cancers and PINs
    Shingo Ashida
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Res 64:5963-72. 2004
    ..These data provide clues to the molecular mechanisms underlying prostatic carcinogenesis, and suggest candidate genes the products of which might serve as molecular targets for the prevention and treatment of PC...
  54. ncbi Apolipoprotein D is down-regulated during malignant transformation of neurofibromas
    Stephen Hunter
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Pathol 36:987-93. 2005
    b>Apolipoprotein D (apoD) expression was studied in nonneoplastic peripheral nerve, neurofibromas (NFs), and malignant peripheral nerve sheath tumors (MPNSTs) by quantitative polymerase chain reaction, in situ hybridization, and ..
  55. ncbi Gene expression pathways induced by axotomy and decentralization of rat superior cervical ganglion neurons
    Arianna Del Signore
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita La Sapienza, Piazzale A Moro, 5, 00185 Roma, Italy
    Eur J Neurosci 23:65-74. 2006
    ..These genes code for extracellular matrix/space [apolipoprotein D (apoD), decorin, collagen alpha1 type I, collagen alpha1 type III] and intermediate filament (vimentin) ..
  56. ncbi Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction
    Jörg van den Boom
    Department of Neuropathology, Heinrich Heine University, Dusseldorf, Germany
    Int J Cancer 119:2330-8. 2006
    ..Taken together, we identified interesting novel candidate genes that likely contribute to glioma progression and provide first evidence for a role of epigenetic silencing of AMOG in malignant glioma cells...
  57. ncbi Progression-associated genes in astrocytoma identified by novel microarray gene expression data reanalysis
    Tobey J Macdonald
    Center for Cancer and Immunology Research, Children s Research Institute, Department of Hematology Oncology, Children s National Medical Center, Washington, DC, USA
    Methods Mol Biol 377:203-22. 2007
    ..Further investigation is needed to evaluate the role of APOD, as well as the other genes identified, in malignant astrocytoma development...
  58. ncbi Structural insight into the dual ligand specificity and mode of high density lipoprotein association of apolipoprotein D
    Andreas Eichinger
    Lehrstuhl fur Biologische Chemie, Technische Universitat Munchen, 85350 Freising Weihenstephan, Germany
    J Biol Chem 282:31068-75. 2007
    Human apolipoprotein D (ApoD) occurs in plasma associated with high density lipoprotein...
  59. ncbi Comparison of apolipoprotein D determination methods in breast cancer
    Håvard Søiland
    Department of Surgery, Stavanger University Hospital, Stavanger, Norway
    Anticancer Res 28:1151-60. 2008
    b>Apolipoprotein D (ApoD) is a promising prognostic and predictive factor in breast cancer, but the analysis methods and results vary.
  60. pmc Evolution of the aging brain transcriptome and synaptic regulation
    Patrick M Loerch
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 3:e3329. 2008
    ..are conserved in all three species, including robust age-dependent upregulation of the neuroprotective gene apolipoprotein D (APOD) and downregulation of the synaptic cAMP signaling gene calcium/calmodulin-dependent protein kinase IV (..
  61. doi Decreased kainate receptors in the hippocampus of apolipoprotein D knockout mice
    Simone Boer
    The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 34:271-8. 2010
    b>Apolipoprotein D (ApoD) has many actions critical to maintaining mammalian CNS function...
  62. pmc A role of apolipoprotein D in triglyceride metabolism
    German Perdomo
    Rangos Research Center, Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    J Lipid Res 51:1298-311. 2010
    ..Aberrant expression of apolipoproteins is associated with metabolic abnormalities. Here we characterized apolipoprotein D (apoD) in triglyceride metabolism...
  63. doi Characterization of nuclear factors modulating the apolipoprotein D promoter during growth arrest: implication of PARP-1, APEX-1 and ERK1/2 catalytic activities
    Louis Charles Levros
    Laboratoire de Biologie Moleculaire, Departement des Sciences Biologiques, and Centre BioMed, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    Biochim Biophys Acta 1803:1062-71. 2010
    Human Apolipoprotein D (apoD) is upregulated under several stress conditions and pathological situations such as neurodegenerative diseases and cancers...
  64. doi Gender differences in apolipoprotein D expression during aging and in Alzheimer disease
    Cristina Ordóñez
    Dpt Morfología y Biología Celular, Facultad de Biología y Medicina, Universidad de Oviedo, Oviedo, Spain
    Neurobiol Aging 33:433.e11-20. 2012
    b>Apolipoprotein D (Apo D) is a lipocalin expressed in a wide variety of mammalian tissues...
  65. pmc Candidate genes for carotenoid coloration in vertebrates and their expression profiles in the carotenoid-containing plumage and bill of a wild bird
    N Walsh
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 ITN, UK
    Proc Biol Sci 279:58-66. 2012
    ..Our identification of a number of potential carotenoid genes in different functional categories provides a critical starting point for future work on carotenoid colour regulation in vertebrate taxa...
  66. pmc Endothelial cells downregulate apolipoprotein D expression in mural cells through paracrine secretion and Notch signaling
    Mohanasundari Pajaniappan
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, USA
    Am J Physiol Heart Circ Physiol 301:H784-93. 2011
    ..In studying genes regulated by this interaction, we identified apolipoprotein D (APOD) as one gene that is downregulated in mural cells by coculture with endothelial cells...
  67. doi Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: implications for lipid antioxidant activity and Alzheimer's disease
    Surabhi Bhatia
    Neuroscience Research Australia, Sydney, NSW, Australia
    Biochem J 442:713-21. 2012
    ApoD (apolipoprotein D) is up-regulated in AD (Alzheimer's disease) and upon oxidative stress. ApoD inhibits brain lipid peroxidation in vivo, but the mechanism is unknown...
  68. doi The RNA-binding protein XSeb4R regulates maternal Sox3 at the posttranscriptional level during maternal-zygotic transition in Xenopus
    Souhila Bentaya
    Laboratoire de Génétique du Développement, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires IBMM, Rue des Profs Jeener et Brachet 12, B 6041 Gosselies, Belgium
    Dev Biol 363:362-72. 2012
    ..K., an ectodermal marker. Overall, our data suggest XSeb4R as a novel player in gene expression regulation, acting at the posttranscriptional level during ectoderm specification in Xenopus...
  69. doi Fibroblast growth factor 8b causes progressive stromal and epithelial changes in the epididymis and degeneration of the seminiferous epithelium in the testis of transgenic mice
    Teresa Elo
    Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland
    Biol Reprod 86:157, 1-12. 2012
    ..in the prostate of FGF8-b-Tg mice, such as osteopontin (Spp1) connective tissue growth factor (Ctgf), apolipoprotein D (Apod), and FGF receptor 1c (Fgfr1-c), were also upregulated in the epididymides, suggesting that similar ..
  70. doi Western blots
    Lita A Freeman
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 1027:369-85. 2013
    ..This method can be used for Western blotting of virtually any protein as well as native lipoprotein particles. ..
  71. pmc Lifelong expression of apolipoprotein D in the human brainstem: correlation with reduced age-related neurodegeneration
    Ana Navarro
    Instituto de Neurociencias del Principado de Asturias INEUROPA, Dpto Morfología y Biología Celular, Facultad de Biología y Medicina, Universidad de Oviedo, Asturias, Spain
    PLoS ONE 8:e77852. 2013
    The lipocalin apolipoprotein D (Apo D) is upregulated in peripheral nerves following injury and in regions of the central nervous system, such as the cerebral cortex, hippocampus, and cerebellum, during aging and progression of certain ..
  72. pmc ApoD mediates binding of HDL to LDL and to growing T24 carcinoma
    Sten Braesch-Andersen
    Mabtech, Nacka Strand, Sweden
    PLoS ONE 9:e115180. 2014
    ..In the current paper, we conclude that apoD mediates binding of HDL to LDL and to growing T24 carcinomas, thereby highlighting the importance of apoD in lipid metabolism. ..
  73. doi Aging without Apolipoprotein D: Molecular and cellular modifications in the hippocampus and cortex
    Diego Sanchez
    Instituto de Biología y Genética Molecular Departamento de Bioquímica y Biología Molecular y Fisiología, Universidad de Valladolid CSIC, Valladolid, Spain
    Exp Gerontol 67:19-47. 2015
    ..b>Apolipoprotein D (ApoD) is one of the few genes with a consistent and evolutionarily conserved up-regulation in the aged brain...
  74. pmc Apolipoprotein D Internalization Is a Basigin-dependent Mechanism
    Ouafa Najyb
    From the Laboratoire de Biologie Moléculaire and
    J Biol Chem 290:16077-87. 2015
    b>Apolipoprotein D (apoD), a member of the lipocalin family, is a 29-kDa secreted glycoprotein that binds and transports small lipophilic molecules...
  75. pmc Cerebral Apolipoprotein-D Is Hypoglycosylated Compared to Peripheral Tissues and Is Variably Expressed in Mouse and Human Brain Regions
    Hongyun Li
    Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia
    PLoS ONE 11:e0148238. 2016
    ....
  76. ncbi Identification, characterization, and tissue distribution of apolipoprotein D in the rat
    J K Boyles
    Gladstone Foundation Laboratories, San Francisco CA 94140 0608
    J Lipid Res 31:2243-56. 1990
    ..Moreover, many of the same cell types varied dramatically in their content of apoD in different tissues, suggesting that the uptake or secretion of apoD by cells is regulated...
  77. ncbi Affinity labeling of oxaloacetate decarboxylase by novel dichlorotriazine linked alpha-ketoacids
    N E Labrou
    Department of Agricultural Biotechnology, Agricultural University of Athens, Greece
    J Protein Chem 18:729-33. 1999
    ..8, indicating a possible histidine derivatization by the label. These results show that APOD and MPD demonstrate the characteristics of an active-site probe towards the oxaloacetate binding site of oxaloacetate decarboxylase...
  78. ncbi Differences in neuroanatomical sites of apoD elevation discriminate between schizophrenia and bipolar disorder
    E A Thomas
    Department of Molecular Biology, The Scripps Research Institute, 10550 Torrey Pines Road, La Jolla, CA, USA
    Mol Psychiatry 8:167-75. 2003
    We previously demonstrated that apolipoprotein D (apoD) levels are elevated in the dorsolateral prefrontal cortex and caudate obtained postmortem from subjects with schizophrenia and bipolar disorder compared to controls, suggesting a ..
  79. ncbi Molecular characterization and developmental expression pattern of the chicken apolipoprotein D gene: implications for the evolution of vertebrate lipocalins
    Maria D Ganfornina
    Departamento de Bioquímica y Fisiología y Genética Molecular IBGM, Universidad de Valladolid CSIC, Valladolid, Spain
    Dev Dyn 232:191-9. 2005
    The insect Lazarillo and the mammalian apolipoprotein D (ApoD) are orthologous members of the lipocalin protein family. We report the cloning and embryonic expression of chicken ApoD, the first molecularly characterized nonmammalian ApoD...
  80. ncbi Comprehensive regional and temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia-induced gene expression patterns, and reveals a biphasic activation of genes in surviving tissue
    Mattias Rickhag
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, University of Lund, Lund, Sweden
    J Neurochem 96:14-29. 2006
    ....
  81. pmc Solubility engineering and crystallization of human apolipoprotein D
    Amber Nasreen
    Lehrstuhl fur Biologische Chemie, Technische Universitat Munchen, D 85350 Freising Weihenstephan, Germany
    Protein Sci 15:190-9. 2006
    Human apolipoprotein D (ApoD) is a physiologically important member of the lipocalin protein family that was discovered as a peripheral subunit of the high-density lipoprotein (HDL) but is also abundant in other body fluids and organs, ..
  82. ncbi An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen
    A S Doane
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Oncogene 25:3994-4008. 2006
    ..This subset of BCs, characterized by a hormonally regulated transcriptional program and response to androgen, suggests the potential for therapeutic strategies targeting the androgen signaling pathway...
  83. doi p53 family members regulate the expression of the apolipoprotein D gene
    Yasushi Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, S 1, W 17, Chuo Ku, Sapporo, 060 8556 Japan
    J Biol Chem 284:872-83. 2009
    ..We report here that apolipoprotein D (apoD), a member of the lipocalin superfamily of lipid transport proteins, is a direct transcriptional target ..
  84. doi Expression of somatostatin and somatostatin receptor subtypes in Apolipoprotein D (ApoD) knockout mouse brain: An immunohistochemical analysis
    Padmesh S Rajput
    Faculty of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, The University of British Columbia, Vancouver, BC, Canada
    J Chem Neuroanat 38:20-33. 2009
    b>Apolipoprotein D (ApoD) is widely distributed in central and peripheral nervous system...
  85. doi Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels
    Paula J Jansen
    Department of Molecular Cell Biology, Research Institute Brain and Behaviour EURON, University of Maastricht, Maastricht, The Netherlands
    J Alzheimers Dis 18:319-29. 2009
    ..This increase is independent of the apoE-isoform, suggesting that the detrimental effect of apoE4 on the pathogenesis of AD is unlikely to be due to an apoE-isoform effect on brain cholesterol homeostasis...
  86. doi An ERRbeta/gamma agonist modulates GRalpha expression, and glucocorticoid responsive gene expression in skeletal muscle cells
    Shu Ching Mary Wang
    Institute for Molecular Bioscience, The University of Queensland, Services Rd, St Lucia, Queensland 4072, Australia
    Mol Cell Endocrinol 315:146-52. 2010
    ....
  87. pmc Modulation of Apolipoprotein D levels in human pregnancy and association with gestational weight gain
    Sonia Do Carmo
    Centre de recherche BioMed, Departement des Sciences Biologiques, Universite du Quebec a Montreal, Quebec, Canada
    Reprod Biol Endocrinol 7:92. 2009
    b>Apolipoprotein D (ApoD) is a lipocalin involved in several processes including lipid transport, but its modulation during human pregnancy was never examined.
  88. doi Effects of chronic Clozapine administration on apolipoprotein D levels and on functional recovery following experimental stroke
    Karsten Ruscher
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, University of Lund, BMC A13, S 22184 Lund, Sweden
    Brain Res 1321:152-63. 2010
    Elevated brain levels of apolipoprotein D (ApoD) correlate with improved neurological recovery after experimental stroke. Hence, a pharmacological induction of ApoD in the postischemic brain could be beneficial for recovery after stroke...
  89. doi No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels
    Pedro Marques-Vidal
    Centre for Cardiovascular and Metabolic Research Cardiomet, Switzerland
    Atherosclerosis 211:551-7. 2010
    ..To assess the relationships and possible interactions between polymorphisms related to HDL levels and alcohol consumption...
  90. doi Antioxidant activities of recombinant amphioxus (Branchiostoma belcheri) apolipoprotein D
    Yu Zhang
    Department of Marine Biology and Laboratory for Evolution and Development, Ocean University of China, Qingdao 266003, China
    Mol Biol Rep 38:1847-51. 2011
    b>Apolipoprotein D (ApoD), a member of lipocalin, has been recently shown to be involved in regulating protection from oxidative stress...
  91. doi Increased apolipoprotein D dimer formation in Alzheimer's disease hippocampus is associated with lipid conjugated diene levels
    Surabhi Bhatia
    Neuroscience Research Australia, Randwick, NSW, Australia
    J Alzheimers Dis 35:475-86. 2013
    Previous studies indicate that apolipoprotein D (apoD) may have a lipid antioxidant function in the brain...
  92. doi Cell-type specific expression and regulation of apolipoprotein D and E in human endometrium
    Ariane Germeyer
    Department of Gynaecological Endocrinology and Reproductive Medicine, University Hospital Heidelberg, Heidelberg, Germany Electronic address
    Eur J Obstet Gynecol Reprod Biol 170:487-91. 2013
    ..To assess the expression and regulation of antilipoprotein D (ApoD) and antilipoprotein E (ApoE) in human endometrium...
  93. doi Obesity occurring in apolipoprotein E-knockout mice has mild effects on fertility
    Ting Zhang
    Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200135, China
    Reproduction 147:141-51. 2014
    ..However, the deletion of Apoe increased the number of ovarian follicles and the ratio of ovarian follicle atresia and apoptosis. We believe that this work will augment our understanding of the role of Apoe in reproduction. ..
  94. pmc A Western-fed diet increases plasma HDL and LDL-cholesterol levels in apoD-/- mice
    Kamilah Ali
    The City College of New York, Biology Department, New York, New York, United States of America Graduate Center at CUNY, New York, New York, United States of America
    PLoS ONE 9:e115744. 2014
    ..According to studies of human genetics and lipid disorders, plasma apoD levels positively correlate with HDL-cholesterol and apoAI levels. Thus, we tested the hypothesis that apoD was a regulator of HDL metabolism...
  95. pmc Transcriptome comparisons identify new cell markers for theca interna and granulosa cells from small and large antral ovarian follicles
    Nicholas Hatzirodos
    Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia, 5005, Australia
    PLoS ONE 10:e0119800. 2015
    ..Many of these were stromal extracellular matrix genes. MGARP, GLDC, CHST8, GPX3 were identified as new potential markers for granulosa cells, while FBLN5, OGN, RAMP2 were significantly elevated in the theca interna. ..
  96. doi Exceptionally long 5' UTR short tandem repeats specifically linked to primates
    P Namdar-Aligoodarzi
    Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
    Gene 569:88-94. 2015
    ..g. FILIP1L). A number of the identified STRs of ≥5-repeats may be human-specific (e.g. ZMYM3 and DAZAP1). Future work is warranted to examine the importance of the listed genes in primate/human evolution, development, and disease...
  97. pmc Transcriptomic Signatures Mirror the Lack of the Fecundity/Longevity Trade-Off in Ant Queens
    Katharina von Wyschetzki
    LS Zoologie Evolutionsbiologie, Universitat Regensburg, Regensburg, Germany
    Mol Biol Evol 32:3173-85. 2015
    ..Our study provides clear evidence that the alternative regulation of conserved molecular pathways that mediate the interplay among mating, egg laying, and aging underlies the lack of the fecundity/longevity trade-off in ant queens. ..
  98. pmc Expression levels of GSTA2 and APOD genes might be associated with carotenoid coloration in golden pheasant (Chrysolophus pictus) plumage
    Guang Qi Gao
    Research Center for Laboratory of Animal Science, Inner Mongolia University, Hohhot 010070, China
    Dongwuxue Yanjiu 37:144-50. 2016
    ..Further comparison of golden pheasant yellow rump and Lady Amherst's pheasant (Chrysolophus amherstiae) white nape feathers suggested that GSTA2 and APOD played a potential role in carotenoid-based coloration in golden pheasant. ..
  99. doi Analysis of apolipoprotein genes and their involvement in disease response of channel catfish after bacterial infection
    Yujia Yang
    The Fish Molecular Genetics and Biotechnology Laboratory, Aquatic Genomics Unit, School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, AL 36849, USA
    Dev Comp Immunol 67:464-470. 2017
    ..Taken together, these results suggested that apolipoprotein genes may play significant roles in innate immune responses to bacterial pathogens in channel catfish...
  100. ncbi [Estimation of the diagnostic potential of APOD, PTOV1, and EPHA4 for prostatic neoplasms]
    D O Allina
    Russian Medical Academy of Postgraduate Education, Moscow, Russia
    Arkh Patol 78:9-14. 2016
    ..The currently available differential diagnostic panel of antibodies is imperfect, which necessitates a search for novel markers...
  101. doi Amyloid-β25-35 induces apolipoprotein D Synthesis and growth arrest in HT22 hippocampal cells
    Eva Martinez
    Dpt Morfología y Biología Celular, Facultad de Biología y Medicina, Universidad de Oviedo, Oviedo, Spain
    J Alzheimers Dis 30:233-44. 2012
    b>Apolipoprotein D (ApoD) is a secreted glycoprotein that is markedly induced in several pathological and stressful conditions in the nervous system...

Research Grants17

  1. Mapping Adiposity QTLS in the NHLBI Family Heart Study
    Ingrid Borecki; Fiscal Year: 2006
    ..abstract_text> ..
  2. CHOLESTEROL AND NEURODEGENERATION
    Shutish Patel; Fiscal Year: 2001
    ..Our laboratory has focussed on two proteins, apolipoprotein D (apoD) and the recently cloned Niemann-Pick C protein 1 (NCP1) that are important in cholesterol transport in ..
  3. GENETIC EPIDEMIOLOGY OF LIPOPROTEIN/LIPID LEVELS
    M Kamboh; Fiscal Year: 2000
    ....
  4. ROLE OF APOD IN NEURODEGENERATION
    Shutish Patel; Fiscal Year: 2006
    b>Apolipoprotein D (apoD), a member of the lipocalin superfamily of transporters has been implicated in neurodegenerative disorders, neural injury and in neural regeneration...
  5. OLFACTORY INFLUENCES ON PHYSIOLOGICAL PARAMETERS
    George Preti; Fiscal Year: 2000
    ....
  6. Risk Genes in Alzheimer's Disease
    M Kamboh; Fiscal Year: 2006
    ..Recent studies indicate that apolipoprotein D (apoD) is involved in the neurodegenerative as well as neuroregenerative processes...
  7. Towards Mechanistic Explanations of Striatal Disorders
    Elizabeth A Thomas; Fiscal Year: 2010
    ..ARRA Request: 2 R01 NS044169-06A2 Thomas, Elizabeth A. ..
  8. Schizophrenia: Molecular Markers of Disease Progression
    Elizabeth Thomas; Fiscal Year: 2008
    ..Overall, these studies may lead to approaches that will favorably alter the course, treatment and outcome of schizophrenia. ..
  9. QSTAR ELITE PRO HIGH PERFORMANCE QUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETER
    Lin Yan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. PRECLINICAL MODELS FOR HUMAN ASTROCYTOMAS
    David Gutmann; Fiscal Year: 2004
    ..abstract_text> ..
  11. MEMBRANE DEFICITS AND OUTCOME IN SCHIZOPHRENIA
    Jeffrey Yao; Fiscal Year: 2003
    ..Also, the study will shed light on the significance of peripheral membrane dynamics to central membrane phospholipid metabolism over the early course of illness. ..
  12. Neurofibromatosis Foundation International Consortium
    David Gutmann; Fiscal Year: 2003
    ..abstract_text> ..
  13. Identification and Preclinical Evaluation of New Brain Tumor Therapies
    David Gutmann; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  14. PROTEIN 4.1 TUMOR SUPPRESSORS IN MENINGIOMA PATHOGENESIS
    David Gutmann; Fiscal Year: 2003
    ..and (3) analyzing the ability of DAL-1 to impair cell growth and motility. These studies are collectively designed to define the role of this novel family of growth regulators in meningioma tumorigenesis and progression. ..
  15. FUNCTIONAL ANALYSIS OF NF2 GENE MUTATIONS
    David Gutmann; Fiscal Year: 2003
    ..Our ability to design rational therapies for schwannomas and meningiomas is dependent on an improved understanding of the mechanisms by which loss of merlin expression and function promotes tumor formation. ..
  16. Molecular Determinants of Neural Stem Cell Function
    David Gutmann; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  17. NEUROFIBROMIN AS A NEGATIVE REGULATOR FOR ASTROCYTES
    David Gutmann; Fiscal Year: 2002
    ....