apolipoprotein B

Summary

Gene Symbol: apolipoprotein B
Description: apolipoprotein B
Alias: FLDB, LDLCQ4, apoB-100, apoB-48, apolipoprotein B-100, apolipoprotein B (including Ag(x) antigen), apolipoprotein B48
Species: human

Top Publications

  1. ncbi Hyperapobetalipoproteinemia with compositional abnormality of LDL and IDL, a characteristic lipoprotein alteration in essential hypertension
    K I Ryomoto
    The Department of Atherosclerosis, Metabolism and Clinical Nutrition, and Research Institute, National Cardiovascular Center, Osaka, Japan
    Am J Hypertens 13:617-24. 2000
  2. pmc C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme
    Debnath Mukhopadhyay
    Department of Medicine, Washington University Medical School, St Louis, MO 63110, USA
    Am J Hum Genet 70:38-50. 2002
  3. ncbi Apolipoproteins A-1 and B and the likelihood of non-fatal stroke and myocardial infarction -- data from The Third National Health and Nutrition Examination Survey
    Adnan I Qureshi
    Department of Neurosurgery, State University of New York at Buffalo, NY 14209 1194, USA
    Med Sci Monit 8:CR311-6. 2002
  4. ncbi Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells
    John J Liang
    Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    J Biol Chem 279:44938-44. 2004
  5. ncbi A single 1-h bout of evening exercise increases basal FFA flux without affecting VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics in untrained lean men
    Faidon Magkos
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 292:E1568-74. 2007
  6. ncbi Human apolipoprotein B: structure of carboxyl-terminal domains, sites of gene expression, and chromosomal localization
    T J Knott
    Science 230:37-43. 1985
  7. ncbi The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70
    E A Fisher
    Laboratory of Lipoprotein Research, Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 272:20427-34. 1997
  8. ncbi Site-specific glycosylation analysis of human apolipoprotein B100 using LC/ESI MS/MS
    Akira Harazono
    National Institute of Health Sciences, Division of Biological Chemistry and Biologicals, 1 18 1 Kami yoga, Setagaya Ku, Tokyo 158 8501, Japan
    Glycobiology 15:447-62. 2005
  9. ncbi Analysis of the apolipoprotein B gene 3' hypervariable region among nationals of the Abu Dhabi Emirate and comparisons with other populations
    P M Frossard
    Departments of Pathology, Faculty of Medicine and Health Sciences, UAE University, and Internal Medicine, Tawam Hospital, Al Ain, United Arab Emirates
    Ann Saudi Med 19:490-4. 1999
  10. ncbi Haplotype analysis of signal peptide (insertion/deletion) and XbaI polymorphisms of the APOB gene in gallbladder cancer
    Sachchida Nand Pandey
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Liver Int 27:1008-15. 2007

Research Grants

  1. Avoiding toxicity associated with MTP ablation
    M Mahmood Hussain; Fiscal Year: 2013
  2. M Mahmood Hussain; Fiscal Year: 2014
  3. Nassrin Dashti; Fiscal Year: 2015
  4. Shadab A Siddiqi; Fiscal Year: 2016
  5. Gang Ren; Fiscal Year: 2016
  6. Zahid Ahmad; Fiscal Year: 2016
  7. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
  8. Kiran Musunuru; Fiscal Year: 2016
  9. Screens for novel compounds to correct diabetic postprandial dyslipidemia
    Kevin Jon Williams; Fiscal Year: 2011
  10. Jean Marc Schwarz; Fiscal Year: 2014

Detail Information

Publications233 found, 100 shown here

  1. ncbi Hyperapobetalipoproteinemia with compositional abnormality of LDL and IDL, a characteristic lipoprotein alteration in essential hypertension
    K I Ryomoto
    The Department of Atherosclerosis, Metabolism and Clinical Nutrition, and Research Institute, National Cardiovascular Center, Osaka, Japan
    Am J Hypertens 13:617-24. 2000
    ..Characteristic disorders of pure essential hypertension are characterized by hyperapobetalipoproteinemia and small dense LDL...
  2. pmc C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme
    Debnath Mukhopadhyay
    Department of Medicine, Washington University Medical School, St Louis, MO 63110, USA
    Am J Hum Genet 70:38-50. 2002
    ..addition, the role, if any, of apobec-1, the catalytic deaminase that mediates C-->U editing of mammalian apolipoprotein B (apoB) RNA, was unresolved...
  3. ncbi Apolipoproteins A-1 and B and the likelihood of non-fatal stroke and myocardial infarction -- data from The Third National Health and Nutrition Examination Survey
    Adnan I Qureshi
    Department of Neurosurgery, State University of New York at Buffalo, NY 14209 1194, USA
    Med Sci Monit 8:CR311-6. 2002
    ..The measurement of plasma apolipoproteins (APO) has been proposed for predicting the risk of cardiovascular diseases. However, the association between APOs and stroke is not well defined...
  4. ncbi Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells
    John J Liang
    Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    J Biol Chem 279:44938-44. 2004
    ..to investigate the effects of isolated increases in triglycerides (TG) or cholesteryl esters (CE) on apolipoprotein B (apoB) lipoprotein biogenesis...
  5. ncbi A single 1-h bout of evening exercise increases basal FFA flux without affecting VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics in untrained lean men
    Faidon Magkos
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 292:E1568-74. 2007
    ..the evening increases basal whole-body free fatty acid (FFA) flux and fat oxidation, decreases hepatic VLDL-apolipoprotein B-100 (apoB-100) secretion, and enhances removal efficiency of VLDL-triglyceride (TG) from the circulation the ..
  6. ncbi Human apolipoprotein B: structure of carboxyl-terminal domains, sites of gene expression, and chromosomal localization
    T J Knott
    Science 230:37-43. 1985
    ..The apo-B100 gene is expressed primarily in liver and, to a lesser extent, in small intestine, but in no other tissues. The gene for apo-B100 is located in the p24 region (near the tip of the short arm) of chromosome 2...
  7. ncbi The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70
    E A Fisher
    Laboratory of Lipoprotein Research, Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 272:20427-34. 1997
    b>Apolipoprotein B (apoB) is the major protein component of atherogenic lipoproteins of hepatic origin...
  8. ncbi Site-specific glycosylation analysis of human apolipoprotein B100 using LC/ESI MS/MS
    Akira Harazono
    National Institute of Health Sciences, Division of Biological Chemistry and Biologicals, 1 18 1 Kami yoga, Setagaya Ku, Tokyo 158 8501, Japan
    Glycobiology 15:447-62. 2005
    ..These results are useful for understanding the structure of LDL particles and oligosaccharide function in LDL-receptor ligand binding...
  9. ncbi Analysis of the apolipoprotein B gene 3' hypervariable region among nationals of the Abu Dhabi Emirate and comparisons with other populations
    P M Frossard
    Departments of Pathology, Faculty of Medicine and Health Sciences, UAE University, and Internal Medicine, Tawam Hospital, Al Ain, United Arab Emirates
    Ann Saudi Med 19:490-4. 1999
    Among all the polymorphic markers available to date, a hypervariable region located in the 3' of the human apolipoprotein B gene has been extensively studied in global populations throughout the world.
  10. ncbi Haplotype analysis of signal peptide (insertion/deletion) and XbaI polymorphisms of the APOB gene in gallbladder cancer
    Sachchida Nand Pandey
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Liver Int 27:1008-15. 2007
    ..The XbaI and insertion/deletion (ins/del) polymorphism of Apolipoprotein B (APOB) appears to influence cholesterol homoeostasis and possibly risk for gallstone disease...
  11. doi Association of polymorphisms at restriction enzyme recognition sites of apolipoprotein B and E gene with dyslipidemia in children undergoing primary nephrotic syndrome
    Peng Hu
    Department of Pediatrics, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China
    Mol Biol Rep 36:1015-21. 2009
    ..Recent studies have shown that genetic basis may be involved in the onset of HLP secondary to PNS. ApoB and E have been identified as the important candidate genes for lipid abnormalities...
  12. ncbi Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway
    E Sehayek
    Department of Medicine B, Hadassah University Hospital, Jerusalem, Israel
    J Biol Chem 266:18259-67. 1991
    ....
  13. pmc Isolation and characterization of sulfhydryl and disulfide peptides of human apolipoprotein B-100
    C Y Yang
    Baylor College of Medicine, Houston, TX
    Proc Natl Acad Sci U S A 87:5523-7. 1990
    Twenty-three of the 25 cysteine residues in apolipoprotein B-100 have been isolated directly from tryptic or peptic peptide mixtures...
  14. pmc The complete sequence and structural analysis of human apolipoprotein B-100: relationship between apoB-100 and apoB-48 forms
    C Cladaras
    EMBO J 5:3495-507. 1986
    We have isolated and sequenced overlapping cDNA clones covering the entire sequence of human apolipoprotein B-100 (apoB-100)...
  15. pmc Complete cDNA and derived protein sequence of human apolipoprotein B-100
    T J Knott
    Nucleic Acids Res 14:7501-3. 1986
  16. pmc Familial ligand-defective apolipoprotein B. Identification of a new mutation that decreases LDL receptor binding affinity
    C R Pullinger
    Cardiovascular Research Institute, University of California, San Francisco 94143
    J Clin Invest 95:1225-34. 1995
    Detection of new ligand-defective mutations of apolipoprotein B (apoB) will enable identification of sequences involved in binding to the LDL receptor...
  17. ncbi Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state
    K M Linnik
    Department of Biophysics, Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 273:21368-73. 1998
    ..ERp72 and GRP94 may also mediate the folding of more advanced folding intermediates and/or target the misfolded underlipidated pool of apoB for degradation...
  18. ncbi Proteasome-mediated degradation of apolipoprotein B targets both nascent peptides cotranslationally before translocation and full-length apolipoprotein B after translocation into the endoplasmic reticulum
    W Liao
    Departments of Medicine and Cell Biology, Division of Endocrinology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 273:27225-30. 1998
    A major portion of newly synthesized apolipoprotein B (apoB) is degraded intracellularly. This degradation has been demonstrated to be mediated largely by the ubiquitin-proteasome pathway...
  19. ncbi Apoprotein B degradation is promoted by the molecular chaperones hsp90 and hsp70
    V Gusarova
    Department of Medicine, Cardiovascular Institute, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029, USA
    J Biol Chem 276:24891-900. 2001
    ..Overall, our data suggest that hsp90 facilitates the interaction between endoplasmic reticulum-associated apoB and components of the proteasomal pathway, perhaps in cooperation with hsp70...
  20. ncbi The effect of six polymorphisms in the Apolipoprotein B gene on parameters of lipid metabolism in a Danish population
    J Bentzen
    Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Denmark
    Clin Genet 61:126-34. 2002
    ..the effect of six single nucleotide polymorphisms in codons 71, 591, 2488, 2712, 3611, and 4154 of the apolipoprotein B gene on fasting levels of triglyceride, VLDL-, LDL-, HDL- and total cholesterol and on body mass index (BMI) ..
  21. ncbi The N-linked oligosaccharides at the amino terminus of human apoB are important for the assembly and secretion of VLDL
    Jelena Vukmirica
    Lipoprotein and Atherosclerosis Group, Department of Pathology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada, K1Y 4W7
    J Lipid Res 43:1496-507. 2002
    We determined the role of N-linked glycosylation of apolipoprotein B (apoB) in the assembly and secretion of lipoproteins using transfected rat hepatoma McA-RH7777 cells expressing human apoB-17, apoB-37, and apoB-50, three apoB variants ..
  22. ncbi Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B
    Jianying Zhang
    Department of Physiology and Biophysics, Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 278:7459-68. 2003
    We have previously demonstrated that endoplasmic reticulum (ER)-resident molecular chaperones interact with apolipoprotein B-100 (apoB) during its maturation...
  23. ncbi The X-X-/E+E+ genotype of the XbaI/EcoRI polymorphisms of the apolipoprotein B gene as a marker of coronary artery disease in a Brazilian sample
    M Scartezini
    Departamento de Patologia Médica, Universidade Federal do Parana, Curitiba, PR, Brasil
    Braz J Med Biol Res 36:369-75. 2003
    Studies that consider polymorphisms within the apolipoprotein B (apo B) gene as risk factors for coronary artery disease (CAD) have reported conflicting results...
  24. ncbi Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells
    Jun shan Liang
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 278:23984-8. 2003
    ..Together, these results indicate that an ER-associated protein, gp78, is a bona fide E3 ligase in the apoB ER-associated degradation pathway...
  25. ncbi [Relationship among the XhaI and EcoRI locus polymorphisms of apolipoprotein B gene, serum lipid metabolism and gallstone disease]
    Yong Fei Tan
    Yixing People s Hospital, Jiangsu Province, Yixing 214200, China
    Zhonghua Yi Xue Za Zhi 83:844-7. 2003
    To explore the relationship between the XbaI and EcoRI locus polymorphisms of apolipoprotein B gene and gallstone disease.
  26. ncbi Apolipoprotein B-100 XbaI gene polymorphism in gallbladder cancer
    Mahendra Kumar Singh
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India
    Hum Genet 114:280-3. 2004
    Genetic polymorphisms in the apolipoprotein B (apoB) gene have been reported to be associated with altered serum lipids and susceptibility to cholesterol gallstones (GS)...
  27. pmc Polymorphisms at cholesterol 7alpha-hydroxylase, apolipoproteins B and E and low density lipoprotein receptor genes in patients with gallbladder stone disease
    Zhao Yan Jiang
    Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    World J Gastroenterol 10:1508-12. 2004
    ....
  28. ncbi Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review
    Melissa A Austin
    Institute for Public Health Genetics and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, 1959 NE Pacific Avenue, Seattle, WA 98195, USA
    Am J Epidemiol 160:407-20. 2004
    ..FH can result from mutations in the low density lipoprotein receptor gene (LDLR), the apolipoprotein B-100 gene (APOB), and the recently identified proprotein convertase subtilisin/kexin type 9 gene (PCSK9)...
  29. ncbi [Low density lipoprotein receptor gene mutations in patients with clinical diagnosis of familial hypercholesterolemia.]
    A N Meshkov
    Russian Cardiology Research Complex ul Tretiya Cherepkovskaya, 15a, 121552 Moscow, Russia
    Kardiologiia 44:58-61. 2004
    ..Low density lipoprotein receptor (LDLR) gene mutations cause familial hypercholesterolemia which is associated with elevated risk of ischemic heart disease...
  30. ncbi Hepatitis C virus nonstructural proteins inhibit apolipoprotein B100 secretion
    Angela M Domitrovich
    Department of Medicine, Moores Cancer Center, University of California at San Diego, La Jolla, California 92093 0803, USA
    J Biol Chem 280:39802-8. 2005
    ..Further evidence is presented for the interaction between the HCV nonstructural protein 5A and apoB100. These results provide further insight into the alteration of lipid metabolism by HCV...
  31. ncbi Genetic variations of the apolipoprotein B gene in Turkish patients with coronary artery disease
    Belgin S Duman
    Department of Medical Biology and Genetics, School of Medicine, Kadir Has University, Istanbul, Turkey
    Ann Hum Biol 32:620-9. 2005
    The results of studies that clarify the association of genetic markers at the apolipoprotein B (apo B) gene (EcoRI and XbaI polymorphisms) with coronary artery disease (CAD) are not consistent and suggest that the effect is context ..
  32. ncbi Mutational analysis in UK patients with a clinical diagnosis of familial hypercholesterolaemia: relationship with plasma lipid traits, heart disease risk and utility in relative tracing
    Steve E Humphries
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, Rayne Building, 5 University Street, London WC1E 6JJ, UK
    J Mol Med (Berl) 84:203-14. 2006
    ..9%) of the patients had the R3500Q mutation in the apolipoprotein B (APOB) gene...
  33. ncbi Effect of age on the association of non-high-density-lipoprotein cholesterol and apolipoprotein B with cardiovascular mortality in a Mediterranean population with type 2 diabetes: the Casale Monferrato study
    G Bruno
    Department of Internal Medicine, University of Turin, I 10126 Turin, Italy
    Diabetologia 49:937-44. 2006
    ..The aim of this population-based study was to compare the association of non-HDL-cholesterol, ApoB and the ApoB:ApoA-I ratio with cardiovascular mortality in people with type 2 diabetes...
  34. pmc Preferential association of Hepatitis C virus with apolipoprotein B48-containing lipoproteins
    Olivier Diaz
    IFR 128 Biosciences Lyon Gerland, INSERM U503, 21 Avenue Tony Garnier, 69007 Lyon, France
    J Gen Virol 87:2983-91. 2006
    ..These data raise the question of the contribution of the intestine to the viral load and suggest that the virus could take advantage of TRL assembly and secretion for its own production and of TRL fate to be delivered to the liver...
  35. ncbi Apolipoprotein B gene 3'VNTR polymorphism: association with plasma lipids and coronary heart disease in Han Chinese
    Sheng kai Yan
    Division of Clinical Biochemistry, Department of Laboratory Medicine, Peking Union Medical College Hospital, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Clin Chem Lab Med 44:1199-205. 2006
    Studies that considered polymorphisms within the apolipoprotein B (APOB) gene as risk factors for coronary heart disease (CHD) have reported conflicting results.
  36. pmc Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk
    S E Humphries
    J Med Genet 43:943-9. 2006
    ..Patients and..
  37. ncbi Apolipoprotein B (APOB) gene polymorphism in patients with gallbladder disease
    Mateusz Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Arch Med Res 38:360-3. 2007
    ..An association between plasma lipoprotein levels and gallstone disease (GSD) was presented. Apolipoprotein B is an essential structural component of triglyceride-rich lipoprotein particles and plays an important role ..
  38. ncbi Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, MA 02142, USA
    Science 316:1331-6. 2007
    ..The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases...
  39. ncbi ApoB C7623T polymorphism predicts risk for steroid-induced osteonecrosis of the femoral head after renal transplantation
    Tetsurou Hirata
    Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii chou, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
    J Orthop Sci 12:199-206. 2007
    ..In this study, we examined the differences of gene polymorphism frequencies of apolipoprotein B (ApoB) and apolipoprotein A1 (ApoA1), which are important proteins for lipid transport, as well as of lipid ..
  40. pmc Effect of the 3'APOB-VNTR polymorphism on the lipid profiles in the Guangxi Hei Yi Zhuang and Han populations
    Yin Ruixing
    Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, China
    BMC Med Genet 8:45. 2007
    ..Thus, the present study was undertaken to study the effect of the 3'APOB-VNTR polymorphism on the serum lipid levels in the Guangxi Hei Yi Zhuang and Han populations...
  41. pmc The Hsp110 molecular chaperone stabilizes apolipoprotein B from endoplasmic reticulum-associated degradation (ERAD)
    Stacy L Hrizo
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Biol Chem 282:32665-75. 2007
    b>Apolipoprotein B (apoB) is the most abundant protein in low density lipoproteins and plays key roles in cholesterol homeostasis...
  42. pmc LDL-cholesterol concentrations: a genome-wide association study
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
    Lancet 371:483-91. 2008
    ..We therefore did a genome-wide association study of LDL-cholesterol concentrations...
  43. doi Polymorphisms associated with cholesterol and risk of cardiovascular events
    Sekar Kathiresan
    Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, MA 02114, USA
    N Engl J Med 358:1240-9. 2008
    ..We tested the hypothesis that a combination of such SNPs contributes to the risk of cardiovascular disease...
  44. doi The AAA-ATPase p97 facilitates degradation of apolipoprotein B by the ubiquitin-proteasome pathway
    Eric A Fisher
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Lipid Res 49:2149-60. 2008
    ..b>Apolipoprotein B-100 (apoB-100) is an ERAD substrate in liver cells, including the human hepatoma, HepG2...
  45. doi Apolipoprotein B and insulin resistance are good markers of carotid atherosclerosis in patients with type 2 diabetes mellitus
    Kazunari Matsumoto
    Diabetes Center, Sasebo Chuo Hospital, 15 Yamato cho, Sasebo, Nagasaki 857 1195, Japan
    Diabetes Res Clin Pract 82:93-7. 2008
    ..However, recent studies reported that serum levels of apolipoprotein B (Apo B) and Apo B to apolipoprotein A-1 (Apo A-1) ratio were better predictors of atherosclerotic vascular ..
  46. pmc ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes
    Josefin Skogsberg
    The Computational Medicine Group, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
    PLoS ONE 3:e3771. 2008
    Free fatty acids released from adipose tissue affect the synthesis of apolipoprotein B-containing lipoproteins and glucose metabolism in the liver...
  47. doi Association of functional polymorphism of ApoB promoter with hepatitis C virus infection
    Chengliang Zhu
    The State Key Laboratory of Virology, College of Life Sciences and Chinese French Liver Disease Research Institute, Zhongnan Hospital, Wuhan University, Wuhan, PR China
    Clin Chim Acta 401:124-7. 2009
    Hepatitis C virus (HCV) binds to apolipoprotein B (ApoB) and low-density lipoprotein (LDL) before entering into hepatocytes. ApoB promoter polymorphisms influence the levels of ApoB and LDL in blood...
  48. ncbi [Effects of apolipoprotein A1 and B gene polymorphism on avascular necrosis of the femoral head in Chinese population]
    Xiao Yan Wang
    Institute of Basic Theory of China Academy of Chinese Medical Science, Beijing 100700, China
    Zhongguo Gu Shang 21:99-102. 2008
    ..To investigate the effects of Apo A1 and B gene polymorphism on avascular necrosis of the femoral head (ANFH) in north Chinese Han population...
  49. pmc Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study
    Rahul C Deo
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    PLoS Genet 5:e1000342. 2009
    ....
  50. doi Mechanisms targeting apolipoprotein B100 to proteasomal degradation: evidence that degradation is initiated by BiP binding at the N terminus and the formation of a p97 complex at the C terminus
    Angela C Rutledge
    Molecular Structure and Function, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 29:579-85. 2009
    ..Here we demonstrate key roles of BiP, an ER luminal chaperone, and p97, a cytosolic ATPase anchored to the ER membrane, in the targeting of apoB for proteasomal degradation...
  51. doi Genetic diagnosis of familial hypercholesterolemia using a DNA-array based platform
    Rodrigo Alonso
    Lipid Clinic, Fundacion Jimenez Diaz, Madrid, Spain
    Clin Biochem 42:899-903. 2009
    ..This platform includes the use of a DNA micro array, the detection of large gene rearrangements and the complete resequencing of the low-density lipoprotein receptor gene...
  52. doi Apolipoprotein E, CI and B gene polymorphisms in a sample of patients with coronary heart disease in the Kuwaiti population
    Suzanne A Al-Bustan
    Department of Biological Sciences, Faculty of Science, Kuwait University, Safat 13060, Kuwait
    Med Princ Pract 18:294-9. 2009
    ....
  53. ncbi Association of polymorphisms in apolipoprotein A1 and apolipoprotein B genes with lipid profile in Tamilian population
    N Padmaja
    Pharmacogenomics Laboratory, Department of Pharmacology, Jawaharlal Institute of Post Graduate Medical Education and Research, Pondicherry, India
    Indian Heart J 61:51-4. 2009
    ..For the first time genotype distribution of ApoAI and ApoB polymorphisms and their effect on lipid profile was established in Tamilians. Only -75G/A polymorphism of ApoAI was significantly associated with HDL7ndash;C levels...
  54. pmc Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication
    Daniel I Chasman
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Genet 1:21-30. 2008
    ....
  55. pmc Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women
    Sergio Baez
    Division of Social and Environmental Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    World J Gastroenterol 16:372-8. 2010
    ..To determine the effects of genetic variants associated with gallstone formation and capsaicin (a pungent component of chili pepper) metabolism on the risk of gallbladder cancer (GBC)...
  56. doi Mutation detection rate and spectrum in familial hypercholesterolaemia patients in the UK pilot cascade project
    A Taylor
    Great Ormond Street Hospital for Children, London, UK
    Clin Genet 77:572-80. 2010
    ..Even in subjects with a low clinical suspicion of FH, and in those of Indian origin, mutation testing has an acceptable detection rate...
  57. pmc Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data
    Li Ma
    Department of Animal Science, University of Minnesota, USA
    BMC Med Genet 11:55. 2010
    ..Here, we report single-locus and epistasis SNP effects on TC and HDL-C using the Framingham Heart Study (FHS) data...
  58. pmc ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone disease
    Jaime Sánchez-Cuén
    División de Gastroenterología, Hospital Regional ISSSTE, Culiacan, Sinaloa 80230, Mexico
    World J Gastroenterol 16:4685-90. 2010
    ..To determine the possible association of the ApoB-100 (XbaI), ApoE (HhaI) and CYP7A1 (BsaI) gene polymorphisms, with the development of cholesterol gallstone disease (GD) in a Mexican population...
  59. pmc Non-HDL-cholesterol as valid surrogate to apolipoprotein B100 measurement in diabetes: Discriminant Ratio and unbiased equivalence
    Michel P Hermans
    Endocrinology and Nutrition Unit, Universite Catholique de Louvain, 10 Avenue Hippocrate, Brussels 1200, Belgium
    Cardiovasc Diabetol 10:20. 2011
    ..Non-HDL-C represents a simple surrogate for apoB in hypertriglyceridemic and/or T2DM patients. ApoB and non-HDL-C show high correlation, although the degree of mutual concordance remains debated in CV risk evaluation...
  60. doi Validation of human ApoB and ApoAI immunoturbidity assays for non-human primate dyslipidemia and atherosclerosis research
    Zhu Chen
    Atherosclerosis, Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA
    J Cardiovasc Transl Res 4:373-83. 2011
    Emerging evidence suggests apolipoprotein B (apoB) and apolipoprotein AI (apoAI) are strong risk predictors for atherosclerosis...
  61. doi Polymorphism of the apolipoprotein B gene and association with plasma lipid and lipoprotein levels in the Mongolian Buryat
    Kenji Tsunoda
    Department of Legal Medicine, Showa University School of Medicine, Tokyo, Japan
    Biochem Genet 50:249-68. 2012
    Allele frequencies at six RFLP sites (Ins/Del, ApaLI, AluI, XbaI, MspI, and EcoRI) of the apolipoprotein B gene (APOB) and the relationship of genotypes with plasma lipid and lipoprotein levels in the Mongolian Buryat were investigated...
  62. pmc Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adults
    Dong Sik Cho
    Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108, Pyung Dong, Seoul, Jongro Ku 110 746, Republic of Korea
    Cardiovasc Diabetol 11:55. 2012
    ..b>Apolipoprotein B (apo B) is the major apolipoprotein contained within atherogenic lipoproteins such as LDL, and apo B is a ..
  63. doi Polymorphisms XbaI (rs693) and EcoRI (rs1042031) of the ApoB gene are associated with carotid plaques but not with carotid intima-media thickness in patients with diabetes mellitus type 2
    Jovana Nikolajević Starčević
    Institute of Histology and Embryology, Medical Faculty, University of Ljubljana, Slovenia
    Vasa 43:171-80. 2014
    b>Apolipoprotein B is a key structural component of all the atherogenic lipoproteins (LDL, VLDL and IDL). Genetic variations of the ApoB gene may affect plasma ApoB and lipid levels, thus influencing atherogenesis...
  64. ncbi The relationship of molecular genetic to clinical diagnosis of familial hypercholesterolemia in a Danish population
    Dorte Damgaard
    Department of Medicine and Cardiology, Aarhus Sygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Atherosclerosis 180:155-60. 2005
    ....
  65. ncbi Population genetic analysis of the genes APOE, APOB(3'VNTR) and ACE in some black and Amerindian communities from Colombia
    J P Jaramillo-Correa
    Departamento de Ciencias Biologicas, Facultad de Ciencias, Universidad de Los Andes, Colombia
    Hum Hered 52:14-33. 2001
    ..This fact was not observed among the Afrocolombian populations. Nevertheless, an isolation-by-distance Slatkin analysis test did not show a significant clear structure of this special pattern among the Indian tribes studied...
  66. ncbi Five polymorphisms of the apolipoprotein B gene in healthy Bulgarians
    Anelia Horvath
    Department of Chemistry and Biochemistry, Medical University of Sofia, Bulgaria
    Hum Biol 75:69-80. 2003
    ..The major differences in the allele-size distributions are in the frequencies of alleles *31, *39, and *47...
  67. ncbi Polymorphisms in the apolipoprotein B-100 gene: association with plasma lipid concentration and coronary artery disease
    Ratna Dua Puri
    Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
    Indian Heart J 55:60-4. 2003
    The aim of this study was to investigate the association of apolipoprotein B gene polymorphisms with coronary artery disease and lipid levels in Indians.
  68. ncbi Apolipoprotein B 3'-VNTR polymorphism in Eastern European populations
    Dmitry A Verbenko
    Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia
    Eur J Hum Genet 11:444-51. 2003
    b>Apolipoprotein B 3' (3' ApoB) minisatellite polymorphism was studied in healthy unrelated individuals from the Russian Federation and the Republic of Belarus, in 10 populations from five ethnic groups: Russians, Byelorussians, Adygeis, ..
  69. ncbi [Relationship between apolipoprotein E and apolipoprotein B polymorphisms in youths with coronary heart disease]
    Sha Li
    Dongshan People s Hospital of Guangzhou, Guangzhou, Guangdong, 510080PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:241-3. 2003
    ..To investigate hereditary susceptibility to coronary heart disease (CHD) in apolipoprotein E(apo E) and apo B polymorphisms of youths...
  70. ncbi [VNTR3' polymorphism of apoliproprotein B gene in obese people]
    R Jemaa
    Laboratoire de Biochimie, Hopital La Rabta, 1007 Jabbari Tunis, Tunisie
    Ann Biol Clin (Paris) 60:559-64. 2002
    b>Apolipoprotein B (apo B) is the major component of LDL, VLDL and chylomicrons. Variations of lipid concentrations in obese people result from obesity, nutritional and genetic factors...
  71. pmc Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB
    Bernard Khoo
    Endocrinology, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    BMC Mol Biol 8:3. 2007
    b>Apolipoprotein B (APOB) is an integral part of the LDL, VLDL, IDL, Lp(a) and chylomicron lipoprotein particles. The APOB pre-mRNA consists of 29 constitutively-spliced exons...
  72. ncbi Common and rare alleles in apolipoprotein B contribute to plasma levels of low-density lipoprotein cholesterol in the general population
    Marianne Benn
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 93:1038-45. 2008
    We have previously shown that rare mutations in the apolipoprotein B gene (APOB) may result in not only severe hypercholesterolemia and ischemic heart disease but also hypocholesterolemia...
  73. ncbi Common genetic variants that relate to disorders of lipid transport in Spanish subjects with premature coronary artery disease
    L Masana
    Servei de Medicina Interna de Reus C, St Llorenc s n 43201, Reus, Spain
    Clin Sci (Lond) 100:183-90. 2001
    ..05) and the triacylglycerol/HDL ratio (P<0.01). Only the three-codon insertion/deletion variants of the apolipoprotein B signal peptide region discriminated between the two groups with or without arterial disease (P=0.02)...
  74. ncbi Amiodarone-induced changes in lipid metabolism
    S E Kasim
    Harper Hospital, Wayne State University, Detroit, Michigan
    Horm Metab Res 22:385-8. 1990
    ..61 +/- 0.26, 6 weeks 3.36 +/- 0.21 mmol/l, P less than 0.05) and in apolipoprotein B (baseline 1.95 +/- 0.15, 6 weeks 2.26 +/- 0.13 mmol/l, P less than 0.01) concentrations...
  75. ncbi Long-term effects of simvastatin in hypercholesterolemic patients with NIDDM and additional atherosclerotic risk factors. Hyogo Simvastatin Study Group
    T Kazumi
    Department of Medicine, Hyogo Medical Center for Adults, Akashi, Japan
    Horm Metab Res 27:239-43. 1995
    ..Simvastatin produced beneficial effects on serum lipids and apolipoproteins and neutral effects on glycemic control in hypercholesterolemic patients with NIDDM, whether or not they had an additional atherosclerotic risk factor...
  76. ncbi Screening and identification of familial defective apolipoprotein B-100 in clinical samples by capillary gel electrophoresis
    R Lehmann
    , Innere Medizin Abteilung IV, Germany
    J Chromatogr A 744:187-94. 1996
    Familial defective apolipoprotein B-100 (FDB) is a dominantly inherited disorder...
  77. ncbi Plasma lipoprotein (a) levels in Turkish NIDDM patients with and without vascular diabetic complications
    C Erem
    Karadeniz Technical University Faculty of Medicine, Department of Internal Medicine, Trabzon, Turkey
    Acta Cardiol 54:203-7. 1999
    ..05). There were significant correlations between plasma log Lp(a) levels and apolipoprotein B (apo B) in all NIDDM patients (r: 0.68, p < 0.05)...
  78. ncbi Does alpha-1-proteinase inhibitor play a protective role in coronary atherosclerosis?
    D Stakisaitis
    Vilnius University Medical Faculty, Vilnius, Lithuania
    Med Sci Monit 7:701-11. 2001
    ..alpha-1-proteinase inhibitor (alpha-1-PI) might appear to be actively involved in atherogenesis as an important regulator protecting elastic tissue from damage by proteinases as well as lipid accumulation in arterial wall...
  79. pmc Potent and selective PPAR-alpha agonist LY518674 upregulates both ApoA-I production and catabolism in human subjects with the metabolic syndrome
    John S Millar
    Departments of Pharmacology, University of Pennsylvania, 652 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 29:140-6. 2009
    ..We sought to determine the effect of a potent and highly specific PPAR-alpha agonist, LY518674, on apoA-I, apoA-II, and apoB-100 kinetics in humans with metabolic syndrome and low levels of HDL cholesterol (C)...
  80. ncbi High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fatal myocardial infarction (AMORIS study): a prospective study
    G Walldius
    Astra Zeneca, Mölndal and King Gustaf V Research Institute, Karolinska Institute, Stockholm, Sweden
    Lancet 358:2026-33. 2001
    b>Apolipoprotein B (apoB) and apolipoprotein A-I (apoA-I) are thought to be better predictors of acute myocardial infarction than total cholesterol and LDL-cholesterol...
  81. pmc Usefulness of apolipoprotein B/apolipoprotein A-I ratio to predict coronary artery disease independent of the metabolic syndrome in African Americans
    Byambaa Enkhmaa
    Department of Medicine, University of California, Davis, Sacramento, USA
    Am J Cardiol 106:1264-9. 2010
    Studies have demonstrated that the apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio predicts cardiovascular risk better than any of the cholesterol indexes...
  82. doi Plasma apo/lipoproteins disturbances as a precondition for metabolic syndrome in HCV seronegative heroin addicts
    Zanina Jovan Pereska
    University Clinic of Toxicology, Skopje, The Former Yugoslav Republic of Macedonia
    Am J Drug Alcohol Abuse 37:196-202. 2011
    ..Dyslipidemia in heroin addicts is considered to be a precondition for developing metabolic syndrome...
  83. ncbi Moderate dietary salt restriction does not alter insulin resistance or serum lipids in normal men
    A Grey
    Department of Endocrinology, Auckland Hospital, New Zealand
    Am J Hypertens 9:317-22. 1996
    ..cholesterol, high density lipoprotein cholesterol or its subfractions, triglycerides, apolipoprotein A1, or apolipoprotein B between the high salt and low salt periods...
  84. doi The effect of alendronate sodium on carotid artery intima-media thickness and lipid profile in women with postmenopausal osteoporosis
    Murat Celiloglu
    Departments of 1Obstetrics and Gynecology and 2Radiology, Dokuz Eylul University Medical Faculty, Izmir, Turkey
    Menopause 16:689-93. 2009
    ..used in the treatment of osteoporosis, on carotid artery intima-media thickness (IMT), the lipid profile, and apolipoprotein A-I (ApoA-I) and apolipoprotein B (ApoB) levels, which are known to have a role in the atherosclerotic process.
  85. ncbi ApoB but not LDL-cholesterol is reduced by exercise training in overweight healthy men. Results from the 1-year randomized Oslo Diet and Exercise Study
    I Holme
    Department of Sports Medicine, Norwegian School of Sports Sciences, Oslo, Norway
    J Intern Med 262:235-43. 2007
    ....
  86. ncbi Binding of apoB-containing lipoproteins from unfractionated human blood sera to immobilized LDL receptor
    V V Yakushkin
    Institute of Experimental Cardiology, Russian Cardiology Complex, Moscow, 121552, Russia
    Biochemistry (Mosc) 63:1164-71. 1998
    ..The results indicate that the different binding of apoB-containing lipoproteins to the immobilized LDL receptor mainly depended on the different binding of VLDL and not of LDL...
  87. ncbi Apolipoprotein B/apolipoprotein A-I in relation to the metabolic syndrome and change in carotid artery intima-media thickness during 3 years in middle-aged men
    Karin Wallenfeldt
    Institute of Internal Medicine, Sahlgrenska University Hospital, Gothenburg University, Gothenburg, Sweden
    Stroke 35:2248-52. 2004
    The apolipoprotein B (apoB)/apolipoprotein A-I (apoA-I) ratio is a measure of the relationship between different lipoprotein particles and a powerful predictor of coronary death...
  88. ncbi Stroke mortality and the apoB/apoA-I ratio: results of the AMORIS prospective study
    G Walldius
    King Gustaf V Research Institute, Karolinska Institute, Stockholm, Sweden
    J Intern Med 259:259-66. 2006
    ....
  89. ncbi Errors that result from using the TC/HDL C ratio rather than the apoB/apoA-I ratio to identify the lipoprotein-related risk of vascular disease
    A D Sniderman
    Mike Rosenbloom Laboratory for Cardiovascular Research, Royal Victoria Hospital, Montreal, Quebec, Canada
    J Intern Med 259:455-61. 2006
    ..0%. Thus, using the conventional cholesterol ratios rather than the apoB/apoA-I ratio results in frequent and substantial error in the estimation of the lipoprotein-related risk of vascular disease...
  90. doi [Decrease ApoB/ApoA-1 ratio and cardiovascular risk improvement: a tadalafil pleiotropic effect? Preliminary study on healthy volunteers]
    T Roumeguere
    Laboratoire de Medecine Experimentale, unité 222, CHU Charleroi, Universite Libre de Bruxelles, Montigny le Tilleul, Belgique
    Prog Urol 18:1087-91. 2008
    ..Cardiac risk assessment may deserve measurement of Apolipoprotein B/Apolipoprotein A-1 ratio. An elevated ApoB/ApoA-1 ratio is a risk factor for future coronary artery disease...
  91. doi Temporal discrepancies in the association between the apoB/apoA-I ratio and mortality in incident dialysis patients
    M Chmielewski
    Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 265:708-16. 2009
    ..In the general population, a high apoB/apoA-I ratio is a strong risk factor for cardiovascular disease and mortality. However, whether this is the case in chronic kidney disease (CKD) patients is currently unknown...
  92. pmc The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls
    Sarah Parish
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford OX3 7LF, UK
    Eur Heart J 30:2137-46. 2009
    Plasma levels of apolipoprotein B (apoB), the main surface protein on LDL particles, and LDL-C, the amount of cholesterol in those particles, are closely correlated and, considered separately, are positive risk factors...
  93. ncbi Long-term efficacy and tolerability of pravastatin in hypercholesterolemia in patients with non-insulin-dependent diabetes mellitus. Hyogo Pravastatin Study Group
    T Kazumi
    Department of Medicine, Hyogo Medical Center for Adults, Akashi, Japan
    Diabetes Res Clin Pract 27:61-8. 1995
    ..in total serum cholesterol by 19 and 20%, in low-density lipoprotein (LDL) cholesterol by 25 and 29%, in apolipoprotein B by 15 and 19% and in triglycerides by 8 and 5%, respectively...
  94. ncbi Effects of probucol on plasma lipids, lipoproteins and parameters of high density lipoprotein metabolism
    J R Wetterau
    Department of Pharmacology and Cell Biophysics, University of Cincinnati
    Horm Metab Res 24:289-96. 1992
    ..6, 15.0 and 25.7%, respectively, in response to probucol treatment. Plasma levels of apolipoprotein B and apolipoprotein A-I also decreased, while apolipoprotein A-II concentrations were unchanged...
  95. ncbi Transcriptional regulation of the human apolipoprotein genes
    V I Zannis
    Section of Molecular Genetics, Whitaker Cardiovascular Institute, Departments of Medicine and Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118 239, USA
    Front Biosci 6:D456-504. 2001
    ..Understanding the transcriptional regulatory mechanism of the apolipoprotein genes may allow, in the long run, selective increase of anti-atherogenic lipoproteins and thus reduce the risk of cardiovascular disease...
  96. ncbi Oxidation of apolipoprotein B-100 in circulating LDL is related to LDL residence time. In vivo insights from stable-isotope studies
    J Pietzsch
    Institute and Polyclinic of Clinical Metabolic Research, Technical University Dresden, Dresden, Germany
    Arterioscler Thromb Vasc Biol 20:E63-7. 2000
    ..In contrast, LDL(2) seemed to be strongly prone to direct oxidation of apoB-100 in vivo. The longer these particles linger in the circulation, the more apoB-100 Pro/Arg residues become modified...
  97. doi Apolipoproteins, cardiovascular risk and statin response in type 2 diabetes: the Collaborative Atorvastatin Diabetes Study (CARDS)
    V Charlton-Menys
    Cardiovascular Research Group, School of Clinical and Laboratory Sciences, Core Technology Facility 3rd floor, University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK
    Diabetologia 52:218-25. 2009
    Controversy surrounds whether the ratio of apolipoprotein B (ApoB) to apolipoprotein A-I (ApoA-I) is the best lipoprotein discriminator of CHD risk in non-diabetic populations, but the issue has never been investigated in type 2 diabetes.
  98. ncbi Complete phenotypic characterization of apobec-1 knockout mice with a wild-type genetic background and a human apolipoprotein B transgenic background, and restoration of apolipoprotein B mRNA editing by somatic gene transfer of Apobec-1
    M Nakamuta
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Biol Chem 271:25981-8. 1996
    ..These experiments indicate that Apobec-1 is an essential component of the apoB mRNA editing machinery and absence of editing in the knockout animals is a direct consequence of the absence of functional Apobec-1...
  99. ncbi Generation of intracellular signals by low density lipoprotein is independent of the classical LDL receptor
    A Sachinidis
    Medical Policlinic, , Germany
    Am J Hypertens 4:274-9. 1991
    Low density lipoprotein cholesterol (LDL) and apolipoprotein B-100 (1 to 15 micrograms/mL) had no significant influence on the inositol-1,4,5-trisphosphate (InsP3) formation in vascular smooth muscle cells and fibroblasts...
  100. ncbi APOLIPOPROTEIN B: mRNA editing, lipoprotein assembly, and presecretory degradation
    N O Davidson
    Departments of Medicine and Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Annu Rev Nutr 20:169-93. 2000
    ..Although control of lipid secretion in vivo is primarily achieved at the level of lipoprotein particle size, regulation of apoB production by presecretory degradation may be relevant in some dyslipidemic states...
  101. ncbi In vivo regulation of phenylalanine hydroxylation to tyrosine, studied using enrichment in apoB-100
    Mahroukh Rafii
    Division of Gastroentrology and Nutrition, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 294:E475-9. 2008
    ....

Research Grants65

  1. Avoiding toxicity associated with MTP ablation
    M Mahmood Hussain; Fiscal Year: 2013
    ..Proposed studies may lead to new therapeutic modalities for the treatment of various disorders associated with high plasma lipids. ..
  2. M Mahmood Hussain; Fiscal Year: 2014
    ..The outcomes from these studies will impact two fields of biology;lipid metabolism and circadian regulation. Novel understanding about the circadian regulation of lipid metabolism will be garnered. ..
  3. Nassrin Dashti; Fiscal Year: 2015
    ..abstract_text> ..
  4. Shadab A Siddiqi; Fiscal Year: 2016
    ..In preliminary studies we have identified Sar1b as the initiator of VTV budding. Further, our data show apolipoprotein B (apoB) to be the cargo selective protein on ER-VLDL...
  5. Gang Ren; Fiscal Year: 2016
    ..Each LDL particle contains one molecule of apolipoprotein B-100 (apoB-100), a ligand for hepatic clearance of plasma cholesterol via LDL receptors...
  6. Zahid Ahmad; Fiscal Year: 2016
    ..heterogeneous and has been associated with variants in at least three genes including LDL receptor (LDLR), apolipoprotein B-100 (APOB), and proprotein convertase subtilisin-like kexin type 9 (PCSK9)...
  7. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..We seek support for additional blood markers to PROMIS by assaying plasma biomarkers potentially relevant to atherogenesis, plaque rupture and/or thrombosis. ..
  8. Kiran Musunuru; Fiscal Year: 2016
    ..found that carriers of ANGPTL3 nonsense mutations had decreased rates of very-low-density lipoprotein (VLDL) apolipoprotein B (apoB) production and increased fractional catabolic rates for LDL apoB...
  9. Screens for novel compounds to correct diabetic postprandial dyslipidemia
    Kevin Jon Williams; Fiscal Year: 2011
    ..The ultimate goal will be to avert the tremendous excess burden of cardiovascular disease in diabetes. ..
  10. Jean Marc Schwarz; Fiscal Year: 2014
    ..A second objective is to determine the doses of HFCS that increase the absolute and proportional contributions of DNL-fatty acids to postprandial TRL. ..
  11. Ronald M Krauss; Fiscal Year: 2015
    ....
  12. HSPGs as remnant receptors: critical role in diabetic postprandial dyslipidemia
    Kevin Jon Williams; Fiscal Year: 2012
    ..The work will expand our understanding of excess cardiovascular disease in diabetes and provide novel therapeutic targets. ..
  13. Characterization of microRNA-lipid-HCV interactions
    ESPERANCE ANNE KREEK SCHAEFER; Fiscal Year: 2013
    ..Taken together, these studies will serve to clarify the relationship between microRNA-122, HCV, and lipid metabolism and provide insights into the pathogenesis of chronic hepatitis and its related derangements, including steatosis. ..
  14. The altered lipid and protein metabolism of pediatric patients with HIV infection
    Farook Jahoor; Fiscal Year: 2010
    ..Knowledge gained from this project may lead to new nutritional therapies to help prevent these conditions. ..
  15. Sekar Kathiresan; Fiscal Year: 2015
    ..After identifying the causal genes in families, we will test whether these genes influence risk for heart attack in the general population. ..
  16. Genetics of lipoprotein metabolism and CVD in CKD
    DANIEL JAMES RADER; Fiscal Year: 2013
    ..abstract_text> ..
  17. Nutritional and Hormonal Pathways for Reduction of ApoB-lipoproteins
    Li Shin Huang; Fiscal Year: 2013
    ....
  18. DANIEL JAMES RADER; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Lipoproteins containing apolipoprotein B (apoB-LP) are important causal risk factors for coronary artery disease (CAD)...
  19. THOMAS STERLING SCANLAN; Fiscal Year: 2015
    ..4) Determine the mechanism of intracellular uptake of T1AM and search for T1AM target proteins. ..
  20. Markers of the metabolic syndrome linking type 2 diabetes and MI in South Asia
    Danish Saleheen; Fiscal Year: 2010
    ....
  21. New Avenues in GPIHBP1 Research
    Anne Beigneux; Fiscal Year: 2012
    ..abstract_text> ..
  22. Hyperinsulinemia, mTOR activity and plasma lipoproteins
    ALAN RICHARD TALL; Fiscal Year: 2012
    ..However, the underlying mechanisms have remained poorly understood. The proposed studies should provide new insights into the regulation of VLDL secretion and LDLR levels in these conditions. ..
  23. Edward A Fisher; Fiscal Year: 2014
    ..abstract_text> ..
  24. M Mahmood Hussain; Fiscal Year: 2016
    ..If proven, miR-30c might serve as a potentially new therapeutic agent to treat hyperlipidemia, atherosclerosis and other related metabolic disorders. ..
  25. Yury Miller; Fiscal Year: 2014
    ....
  26. Outcomes and Predictors in Mild Cognitive Impairment
    Mary Ganguli; Fiscal Year: 2012
    ..The Awardee will also continue to organize trainee workshops in neglected areas such as project management, principles of neuropsvcholoav for non-psvcholoaists. and scientific writing skills. ..
  27. Henry N Ginsberg; Fiscal Year: 2016
    ..of insulin resistance is very common and is associated with increased assembly and secretion of atherogenic apolipoprotein B (apoB) containing lipoproteins, particularly the triglyceride (TG)-enriched very low density lipoproteins (..
  28. PAMELA RANEL HALL; Fiscal Year: 2015
    ..We identified apolipoprotein B, a component of lipid metabolism, as an essential barrier to invasive S...
  29. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard B Weinberg; Fiscal Year: 2010
    ..We believe that these studies will provide new knowledge on the function of apo A-IV in the complex process of lipoprotein assembly relevant to the dietary control of atherosclerotic cardiovascular disease and obesity. ..
  30. IRA A TABAS; Fiscal Year: 2015
    ..Achieving the stated objective will provide critical information for understanding how necrotic cores form and may help in the design of new therapeutic strategies to prevent the clinical progression of atherosclerotic lesions. ..
  31. Proteostasis Network Factors Involved in Apolipoprotein B Folding and Secretion
    Joseph Genereux; Fiscal Year: 2012
    ..We will identify the factors of the proteostasis network that regulate apoB folding and processing into VLDL, and characterize the impact of these factors on VLDL secretion. ..
  32. Aleem Siddiqui; Fiscal Year: 2016
    ..We further propose to investigate the mechanisms by which HCV gene expression impairs the lipidation of apolipoprotein B-100 (apoB). ApoB represents the major structural component of VLDL...
  33. Jean Marc Schwarz; Fiscal Year: 2016
    ..These findings could inform efforts to develop evidence-based interventions and dietary guidance to mitigate CVD risk. ..
  34. AMPHIPATHIC MOTIFS, LIPOPROTEINS AND ATHEROSCLEROSIS
    Jere P Segrest; Fiscal Year: 2012
    ..Jere P. Segrest, Project Leader). 2) Molecular mechanisms of biogenesis of apolipoprotein B-containing lipoproteins (Dr. Nassrin Dashti, Project Leader)...
  35. Dyslipidemia, Lipoic Acid and Diabetic Vascular Complications in Humanized
    Nobuyo Maeda; Fiscal Year: 2010
    ....
  36. MOLECULAR MECHANISMS OF OXIDATION OF LDL
    Sampath Parthasarathy; Fiscal Year: 1999
    ..The applicant proposes to study mechanisms by which apolipoprotein B (apoB) and amino phospholipids (phosphatidylethanolamine) of LDL play a role in the propagation of lipid ..
  37. Serum amyloid P and chronic noncommunicable diseases
    Weibin Shi; Fiscal Year: 2010
    ..The proposed research offers an opportunity to assess the contribution of serum amyloid P to the development of chronic noncommunicable diseases. ..
  38. THOMAS STERLING SCANLAN; Fiscal Year: 2014
    ....
  39. Amrita Kamat; Fiscal Year: 2016
    ..The study is expected to have an important impact by defining new molecular targets for the prevention and/or treatment of NAFLD and its complications. ..
  40. Effects of amino acids on regional lipid metabolism
    Elisabet Borsheim; Fiscal Year: 2013
    ..The overall goal of this project is to test a novel treatment using nutrient (amino acid) supplementation against this condition in men and women, and to understand how this treatment works. ..
  41. Hepatic Rictor Knockout Mouse Model and the Metabolic Syndrome
    JENNIFER MARIE ROJAS; Fiscal Year: 2012
    ..The possibility of hepatic steatosis will be assessed by liver lipid quantification. ..
  42. Henry N Ginsberg; Fiscal Year: 2014
    ..women, Whites vs non-whites, and dyslipidemics vs non-dyslipidemics. ..
  43. Apo A2, C1 and C2 and Diet in human apoB Metabolism
    Frank Sacks; Fiscal Year: 2005
    ..abstract_text> ..
  44. MACROPHAGE CHYLOMICRON/B48 RECEPTOR, BINDING MECHANISMS
    William Bradley; Fiscal Year: 2004
    ..abstract_text> ..
  45. NICHOLAS DAVIDSON; Fiscal Year: 2016
    ..The longstanding focus of this award has been the posttranscriptional regulation of apolipoprotein B (apoB) RNA editing and the apoB isoform-specific (i.e...
  46. Regulation of Leukocyte Migration by Plasminogen
    JANE LEE HOOVER-PLOW; Fiscal Year: 2013
    ..The objective of this proposal is to determine the mechanisms by which plasminogen regulates cell migration and, thereby, the inflammatory responses that contribute to thrombosis and CVD. ..
  47. Max A Cayo; Fiscal Year: 2016
    ..abstract_text> ..
  48. EDITING OF APOLIPOPROTEIN-B MRNA
    DONNA DRISCOLL; Fiscal Year: 2004
    ..The successful pursuit of these aims should provide insight into the mechanism of apo-B mRNA editing and the function of ACF. ..
  49. MECHANISM OF APOLIPOPROTEIN B-48 BIOGENESIS
    Lawrence Chan; Fiscal Year: 1993
    ..The proposed work will shed light on this process, which also has profound implications for general cell and molecular biology...
  50. GENETIC EPIDEMIOLOGY OF ELEVATED APOB LEVEL
    GAIL JARVIK; Fiscal Year: 1999
    ..Adapted from the Investigator's Abstract) The investigator's overall goal in this project is to map the apolipoprotein B elevating level (BEL) gene by doing a genomic search in pedigrees with familial combined hyperlipidemia, with ..
  51. Premature Aging, Vascular Disease and Endothelial Mechanotransduction
    WILLIAM JAMES ADAMS; Fiscal Year: 2012
    ..This will indicate whether the premature aging model endothelium is predisposed atherosclerosis due to dysfunctional mechanotransduction. ..
  52. Development of CNS-targeted AAV vectors
    MIGUEL S ESTEVES; Fiscal Year: 2012
    ..of CNS-targeted AAV vectors to foster the development of highly effective gene therapy approaches to treat many childhood, adult, and geriatric neurological diseases currently beyond the reach of modern medicine ..
  53. Targets of a cytidine deaminase required for left-right axis in Xenopus
    Alin Vonica; Fiscal Year: 2010
    ..Finding the genes targeted by APOBEC2 will significantly improve our knowledge of a family of proteins increasingly important in human pathology. ..
  54. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    Mary J Mulligan Kehoe; Fiscal Year: 2011
    ....
  55. Endothelial Dysfunction, Oxidative Stress and Risk of Peripheral Arterial Disease
    Kenneth Jay Mukamal; Fiscal Year: 2010
    ..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..
  56. METABOLIC REGULATION OF APOLIPOPROTEIN B MRNA EDITING
    Harold Smith; Fiscal Year: 2003
    DESCRIPTION (adapted from the applicant's description): Apolipoprotein B (apoB) is a non-exchangeable structural component of chylomicrons and of very low density (VLDL), intermediate density (IDL), and low density (LDL) lipoprotein ..
  57. Lipoprotein(a) and Atherosclerosis
    ROBERT PITAS; Fiscal Year: 2007
    ..The proposed studies will increase our understanding of the mechanisms by which Lp(a) contributes to atherogenesis and may lead to more rational means of intervention. ..
  58. Regulation of Apolipoprotein B Secretion
    ALAN ATTIE; Fiscal Year: 2006
    ..This will enable us to differentiate between an interaction with apoB early in the secretory pathway and an interaction that occurs after apoB secretion leading to re-uptake of the lipoprotein particles. ..
  59. INTERACTIONS OF LP(A) WITH SUBENDOTHELIAL CELL MATRIX
    Walter McConathy; Fiscal Year: 1993
    ..These studies should provide a better understanding of the link between plasma lipoproteins, the hemostasis system, and the progression of atherosclerosis...
  60. DIABETES, LIPOPROTEINS AND ACCELERATED VASCULAR DISEASE
    Henry Ginsberg; Fiscal Year: 2000
    ..This will allow for better prevention and more specific intervention in this patient population. ..
  61. MODELS OF ATHEROSCLEROSIS BY TARGETED GENE DUPLICATION
    MYRON HINSDALE; Fiscal Year: 1999
    ..targeting and to use these animal models to study, at the molecular level, the role of increased secretion of apolipoprotein B-containing lipoproteins on atherogenesis...
  62. APOB FOLDING & SECRETION--CHARACTERIZING HELPER PROTEINS
    Haya Herscovitz; Fiscal Year: 2000
    ..research are to study the molecular details of the mechanisms regulating the folding and secretion of apolipoprotein B (apo B)...
  63. REGULATION OF APOB SECRETION IN INBRED MOUSE STRAINS
    Li Shin Huang; Fiscal Year: 2009
    Elevated plasma levels of apolipoprotein B (apo B) and low density lipoprotein (LDL) are associated with a higher risk for atherosclerotic coronary heart disease (CHD), a leading cause of mortality in the industrialized world...
  64. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2004
    ..Thus, the overall project is highly relevant to lipid nutrient absorption and homeostasis. Significantly, it also provides important information on a newly described pathway in posttranscriptional gene regulation. ..
  65. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ....