Genomes and Genes
Gene Symbol: apolipoprotein B
Description: apolipoprotein B
Alias: FLDB, LDLCQ4, apoB-100, apoB-48, apolipoprotein B-100, apolipoprotein B (including Ag(x) antigen), apolipoprotein B48
Publications233 found, 100 shown here
- Hyperapobetalipoproteinemia with compositional abnormality of LDL and IDL, a characteristic lipoprotein alteration in essential hypertensionK I Ryomoto
The Department of Atherosclerosis, Metabolism and Clinical Nutrition, and Research Institute, National Cardiovascular Center, Osaka, Japan
Am J Hypertens 13:617-24. 2000..Characteristic disorders of pure essential hypertension are characterized by hyperapobetalipoproteinemia and small dense LDL...
- C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzymeDebnath Mukhopadhyay
Department of Medicine, Washington University Medical School, St Louis, MO 63110, USA
Am J Hum Genet 70:38-50. 2002..addition, the role, if any, of apobec-1, the catalytic deaminase that mediates C-->U editing of mammalian apolipoprotein B (apoB) RNA, was unresolved...
- Apolipoproteins A-1 and B and the likelihood of non-fatal stroke and myocardial infarction -- data from The Third National Health and Nutrition Examination SurveyAdnan I Qureshi
Department of Neurosurgery, State University of New York at Buffalo, NY 14209 1194, USA
Med Sci Monit 8:CR311-6. 2002..The measurement of plasma apolipoproteins (APO) has been proposed for predicting the risk of cardiovascular diseases. However, the association between APOs and stroke is not well defined...
- Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cellsJohn J Liang
Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
J Biol Chem 279:44938-44. 2004..to investigate the effects of isolated increases in triglycerides (TG) or cholesteryl esters (CE) on apolipoprotein B (apoB) lipoprotein biogenesis...
- A single 1-h bout of evening exercise increases basal FFA flux without affecting VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics in untrained lean menFaidon Magkos
Washington University School of Medicine, St Louis, MO 63110, USA
Am J Physiol Endocrinol Metab 292:E1568-74. 2007..the evening increases basal whole-body free fatty acid (FFA) flux and fat oxidation, decreases hepatic VLDL-apolipoprotein B-100 (apoB-100) secretion, and enhances removal efficiency of VLDL-triglyceride (TG) from the circulation the ..
- Human apolipoprotein B: structure of carboxyl-terminal domains, sites of gene expression, and chromosomal localizationT J Knott
Science 230:37-43. 1985..The apo-B100 gene is expressed primarily in liver and, to a lesser extent, in small intestine, but in no other tissues. The gene for apo-B100 is located in the p24 region (near the tip of the short arm) of chromosome 2...
- The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70E A Fisher
Laboratory of Lipoprotein Research, Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 272:20427-34. 1997b>Apolipoprotein B (apoB) is the major protein component of atherogenic lipoproteins of hepatic origin...
- Site-specific glycosylation analysis of human apolipoprotein B100 using LC/ESI MS/MSAkira Harazono
National Institute of Health Sciences, Division of Biological Chemistry and Biologicals, 1 18 1 Kami yoga, Setagaya Ku, Tokyo 158 8501, Japan
Glycobiology 15:447-62. 2005..These results are useful for understanding the structure of LDL particles and oligosaccharide function in LDL-receptor ligand binding...
- Analysis of the apolipoprotein B gene 3' hypervariable region among nationals of the Abu Dhabi Emirate and comparisons with other populationsP M Frossard
Departments of Pathology, Faculty of Medicine and Health Sciences, UAE University, and Internal Medicine, Tawam Hospital, Al Ain, United Arab Emirates
Ann Saudi Med 19:490-4. 1999Among all the polymorphic markers available to date, a hypervariable region located in the 3' of the human apolipoprotein B gene has been extensively studied in global populations throughout the world.
- Haplotype analysis of signal peptide (insertion/deletion) and XbaI polymorphisms of the APOB gene in gallbladder cancerSachchida Nand Pandey
Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Liver Int 27:1008-15. 2007..The XbaI and insertion/deletion (ins/del) polymorphism of Apolipoprotein B (APOB) appears to influence cholesterol homoeostasis and possibly risk for gallstone disease...
- Association of polymorphisms at restriction enzyme recognition sites of apolipoprotein B and E gene with dyslipidemia in children undergoing primary nephrotic syndromePeng Hu
Department of Pediatrics, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China
Mol Biol Rep 36:1015-21. 2009..Recent studies have shown that genetic basis may be involved in the onset of HLP secondary to PNS. ApoB and E have been identified as the important candidate genes for lipid abnormalities...
- Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathwayE Sehayek
Department of Medicine B, Hadassah University Hospital, Jerusalem, Israel
J Biol Chem 266:18259-67. 1991....
- Isolation and characterization of sulfhydryl and disulfide peptides of human apolipoprotein B-100C Y Yang
Baylor College of Medicine, Houston, TX
Proc Natl Acad Sci U S A 87:5523-7. 1990Twenty-three of the 25 cysteine residues in apolipoprotein B-100 have been isolated directly from tryptic or peptic peptide mixtures...
- The complete sequence and structural analysis of human apolipoprotein B-100: relationship between apoB-100 and apoB-48 formsC Cladaras
EMBO J 5:3495-507. 1986We have isolated and sequenced overlapping cDNA clones covering the entire sequence of human apolipoprotein B-100 (apoB-100)...
- Complete cDNA and derived protein sequence of human apolipoprotein B-100T J Knott
Nucleic Acids Res 14:7501-3. 1986
- Familial ligand-defective apolipoprotein B. Identification of a new mutation that decreases LDL receptor binding affinityC R Pullinger
Cardiovascular Research Institute, University of California, San Francisco 94143
J Clin Invest 95:1225-34. 1995Detection of new ligand-defective mutations of apolipoprotein B (apoB) will enable identification of sequences involved in binding to the LDL receptor...
- Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation stateK M Linnik
Department of Biophysics, Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Biol Chem 273:21368-73. 1998..ERp72 and GRP94 may also mediate the folding of more advanced folding intermediates and/or target the misfolded underlipidated pool of apoB for degradation...
- Proteasome-mediated degradation of apolipoprotein B targets both nascent peptides cotranslationally before translocation and full-length apolipoprotein B after translocation into the endoplasmic reticulumW Liao
Departments of Medicine and Cell Biology, Division of Endocrinology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 273:27225-30. 1998A major portion of newly synthesized apolipoprotein B (apoB) is degraded intracellularly. This degradation has been demonstrated to be mediated largely by the ubiquitin-proteasome pathway...
- Apoprotein B degradation is promoted by the molecular chaperones hsp90 and hsp70V Gusarova
Department of Medicine, Cardiovascular Institute, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029, USA
J Biol Chem 276:24891-900. 2001..Overall, our data suggest that hsp90 facilitates the interaction between endoplasmic reticulum-associated apoB and components of the proteasomal pathway, perhaps in cooperation with hsp70...
- The effect of six polymorphisms in the Apolipoprotein B gene on parameters of lipid metabolism in a Danish populationJ Bentzen
Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Denmark
Clin Genet 61:126-34. 2002..the effect of six single nucleotide polymorphisms in codons 71, 591, 2488, 2712, 3611, and 4154 of the apolipoprotein B gene on fasting levels of triglyceride, VLDL-, LDL-, HDL- and total cholesterol and on body mass index (BMI) ..
- The N-linked oligosaccharides at the amino terminus of human apoB are important for the assembly and secretion of VLDLJelena Vukmirica
Lipoprotein and Atherosclerosis Group, Department of Pathology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada, K1Y 4W7
J Lipid Res 43:1496-507. 2002We determined the role of N-linked glycosylation of apolipoprotein B (apoB) in the assembly and secretion of lipoproteins using transfected rat hepatoma McA-RH7777 cells expressing human apoB-17, apoB-37, and apoB-50, three apoB variants ..
- Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin BJianying Zhang
Department of Physiology and Biophysics, Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Biol Chem 278:7459-68. 2003We have previously demonstrated that endoplasmic reticulum (ER)-resident molecular chaperones interact with apolipoprotein B-100 (apoB) during its maturation...
- The X-X-/E+E+ genotype of the XbaI/EcoRI polymorphisms of the apolipoprotein B gene as a marker of coronary artery disease in a Brazilian sampleM Scartezini
Departamento de Patologia Médica, Universidade Federal do Parana, Curitiba, PR, Brasil
Braz J Med Biol Res 36:369-75. 2003Studies that consider polymorphisms within the apolipoprotein B (apo B) gene as risk factors for coronary artery disease (CAD) have reported conflicting results...
- Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cellsJun shan Liang
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Biol Chem 278:23984-8. 2003..Together, these results indicate that an ER-associated protein, gp78, is a bona fide E3 ligase in the apoB ER-associated degradation pathway...
- [Relationship among the XhaI and EcoRI locus polymorphisms of apolipoprotein B gene, serum lipid metabolism and gallstone disease]Yong Fei Tan
Yixing People s Hospital, Jiangsu Province, Yixing 214200, China
Zhonghua Yi Xue Za Zhi 83:844-7. 2003To explore the relationship between the XbaI and EcoRI locus polymorphisms of apolipoprotein B gene and gallstone disease.
- Apolipoprotein B-100 XbaI gene polymorphism in gallbladder cancerMahendra Kumar Singh
Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India
Hum Genet 114:280-3. 2004Genetic polymorphisms in the apolipoprotein B (apoB) gene have been reported to be associated with altered serum lipids and susceptibility to cholesterol gallstones (GS)...
- Polymorphisms at cholesterol 7alpha-hydroxylase, apolipoproteins B and E and low density lipoprotein receptor genes in patients with gallbladder stone diseaseZhao Yan Jiang
Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
World J Gastroenterol 10:1508-12. 2004....
- Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence reviewMelissa A Austin
Institute for Public Health Genetics and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, 1959 NE Pacific Avenue, Seattle, WA 98195, USA
Am J Epidemiol 160:407-20. 2004..FH can result from mutations in the low density lipoprotein receptor gene (LDLR), the apolipoprotein B-100 gene (APOB), and the recently identified proprotein convertase subtilisin/kexin type 9 gene (PCSK9)...
- [Low density lipoprotein receptor gene mutations in patients with clinical diagnosis of familial hypercholesterolemia.]A N Meshkov
Russian Cardiology Research Complex ul Tretiya Cherepkovskaya, 15a, 121552 Moscow, Russia
Kardiologiia 44:58-61. 2004..Low density lipoprotein receptor (LDLR) gene mutations cause familial hypercholesterolemia which is associated with elevated risk of ischemic heart disease...
- Hepatitis C virus nonstructural proteins inhibit apolipoprotein B100 secretionAngela M Domitrovich
Department of Medicine, Moores Cancer Center, University of California at San Diego, La Jolla, California 92093 0803, USA
J Biol Chem 280:39802-8. 2005..Further evidence is presented for the interaction between the HCV nonstructural protein 5A and apoB100. These results provide further insight into the alteration of lipid metabolism by HCV...
- Genetic variations of the apolipoprotein B gene in Turkish patients with coronary artery diseaseBelgin S Duman
Department of Medical Biology and Genetics, School of Medicine, Kadir Has University, Istanbul, Turkey
Ann Hum Biol 32:620-9. 2005The results of studies that clarify the association of genetic markers at the apolipoprotein B (apo B) gene (EcoRI and XbaI polymorphisms) with coronary artery disease (CAD) are not consistent and suggest that the effect is context ..
- Mutational analysis in UK patients with a clinical diagnosis of familial hypercholesterolaemia: relationship with plasma lipid traits, heart disease risk and utility in relative tracingSteve E Humphries
Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, Rayne Building, 5 University Street, London WC1E 6JJ, UK
J Mol Med (Berl) 84:203-14. 2006..9%) of the patients had the R3500Q mutation in the apolipoprotein B (APOB) gene...
- Effect of age on the association of non-high-density-lipoprotein cholesterol and apolipoprotein B with cardiovascular mortality in a Mediterranean population with type 2 diabetes: the Casale Monferrato studyG Bruno
Department of Internal Medicine, University of Turin, I 10126 Turin, Italy
Diabetologia 49:937-44. 2006..The aim of this population-based study was to compare the association of non-HDL-cholesterol, ApoB and the ApoB:ApoA-I ratio with cardiovascular mortality in people with type 2 diabetes...
- Preferential association of Hepatitis C virus with apolipoprotein B48-containing lipoproteinsOlivier Diaz
IFR 128 Biosciences Lyon Gerland, INSERM U503, 21 Avenue Tony Garnier, 69007 Lyon, France
J Gen Virol 87:2983-91. 2006..These data raise the question of the contribution of the intestine to the viral load and suggest that the virus could take advantage of TRL assembly and secretion for its own production and of TRL fate to be delivered to the liver...
- Apolipoprotein B gene 3'VNTR polymorphism: association with plasma lipids and coronary heart disease in Han ChineseSheng kai Yan
Division of Clinical Biochemistry, Department of Laboratory Medicine, Peking Union Medical College Hospital, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Clin Chem Lab Med 44:1199-205. 2006Studies that considered polymorphisms within the apolipoprotein B (APOB) gene as risk factors for coronary heart disease (CHD) have reported conflicting results.
- Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease riskS E Humphries
J Med Genet 43:943-9. 2006..Patients and..
- Apolipoprotein B (APOB) gene polymorphism in patients with gallbladder diseaseMateusz Kurzawski
Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
Arch Med Res 38:360-3. 2007..An association between plasma lipoprotein levels and gallstone disease (GSD) was presented. Apolipoprotein B is an essential structural component of triglyceride-rich lipoprotein particles and plays an important role ..
- Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levelsRicha Saxena
Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, MA 02142, USA
Science 316:1331-6. 2007..The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases...
- ApoB C7623T polymorphism predicts risk for steroid-induced osteonecrosis of the femoral head after renal transplantationTetsurou Hirata
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii chou, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
J Orthop Sci 12:199-206. 2007..In this study, we examined the differences of gene polymorphism frequencies of apolipoprotein B (ApoB) and apolipoprotein A1 (ApoA1), which are important proteins for lipid transport, as well as of lipid ..
- Effect of the 3'APOB-VNTR polymorphism on the lipid profiles in the Guangxi Hei Yi Zhuang and Han populationsYin Ruixing
Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, China
BMC Med Genet 8:45. 2007..Thus, the present study was undertaken to study the effect of the 3'APOB-VNTR polymorphism on the serum lipid levels in the Guangxi Hei Yi Zhuang and Han populations...
- The Hsp110 molecular chaperone stabilizes apolipoprotein B from endoplasmic reticulum-associated degradation (ERAD)Stacy L Hrizo
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Biol Chem 282:32665-75. 2007b>Apolipoprotein B (apoB) is the most abundant protein in low density lipoproteins and plays key roles in cholesterol homeostasis...
- LDL-cholesterol concentrations: a genome-wide association studyManjinder S Sandhu
Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
Lancet 371:483-91. 2008..We therefore did a genome-wide association study of LDL-cholesterol concentrations...
- Polymorphisms associated with cholesterol and risk of cardiovascular eventsSekar Kathiresan
Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, MA 02114, USA
N Engl J Med 358:1240-9. 2008..We tested the hypothesis that a combination of such SNPs contributes to the risk of cardiovascular disease...
- The AAA-ATPase p97 facilitates degradation of apolipoprotein B by the ubiquitin-proteasome pathwayEric A Fisher
Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
J Lipid Res 49:2149-60. 2008..b>Apolipoprotein B-100 (apoB-100) is an ERAD substrate in liver cells, including the human hepatoma, HepG2...
- Apolipoprotein B and insulin resistance are good markers of carotid atherosclerosis in patients with type 2 diabetes mellitusKazunari Matsumoto
Diabetes Center, Sasebo Chuo Hospital, 15 Yamato cho, Sasebo, Nagasaki 857 1195, Japan
Diabetes Res Clin Pract 82:93-7. 2008..However, recent studies reported that serum levels of apolipoprotein B (Apo B) and Apo B to apolipoprotein A-1 (Apo A-1) ratio were better predictors of atherosclerotic vascular ..
- ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytesJosefin Skogsberg
The Computational Medicine Group, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
PLoS ONE 3:e3771. 2008Free fatty acids released from adipose tissue affect the synthesis of apolipoprotein B-containing lipoproteins and glucose metabolism in the liver...
- Association of functional polymorphism of ApoB promoter with hepatitis C virus infectionChengliang Zhu
The State Key Laboratory of Virology, College of Life Sciences and Chinese French Liver Disease Research Institute, Zhongnan Hospital, Wuhan University, Wuhan, PR China
Clin Chim Acta 401:124-7. 2009Hepatitis C virus (HCV) binds to apolipoprotein B (ApoB) and low-density lipoprotein (LDL) before entering into hepatocytes. ApoB promoter polymorphisms influence the levels of ApoB and LDL in blood...
- [Effects of apolipoprotein A1 and B gene polymorphism on avascular necrosis of the femoral head in Chinese population]Xiao Yan Wang
Institute of Basic Theory of China Academy of Chinese Medical Science, Beijing 100700, China
Zhongguo Gu Shang 21:99-102. 2008..To investigate the effects of Apo A1 and B gene polymorphism on avascular necrosis of the femoral head (ANFH) in north Chinese Han population...
- Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart StudyRahul C Deo
Department of Genetics, Harvard Medical School, Boston, MA, USA
PLoS Genet 5:e1000342. 2009....
- Mechanisms targeting apolipoprotein B100 to proteasomal degradation: evidence that degradation is initiated by BiP binding at the N terminus and the formation of a p97 complex at the C terminusAngela C Rutledge
Molecular Structure and Function, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
Arterioscler Thromb Vasc Biol 29:579-85. 2009..Here we demonstrate key roles of BiP, an ER luminal chaperone, and p97, a cytosolic ATPase anchored to the ER membrane, in the targeting of apoB for proteasomal degradation...
- Genetic diagnosis of familial hypercholesterolemia using a DNA-array based platformRodrigo Alonso
Lipid Clinic, Fundacion Jimenez Diaz, Madrid, Spain
Clin Biochem 42:899-903. 2009..This platform includes the use of a DNA micro array, the detection of large gene rearrangements and the complete resequencing of the low-density lipoprotein receptor gene...
- Apolipoprotein E, CI and B gene polymorphisms in a sample of patients with coronary heart disease in the Kuwaiti populationSuzanne A Al-Bustan
Department of Biological Sciences, Faculty of Science, Kuwait University, Safat 13060, Kuwait
Med Princ Pract 18:294-9. 2009....
- Association of polymorphisms in apolipoprotein A1 and apolipoprotein B genes with lipid profile in Tamilian populationN Padmaja
Pharmacogenomics Laboratory, Department of Pharmacology, Jawaharlal Institute of Post Graduate Medical Education and Research, Pondicherry, India
Indian Heart J 61:51-4. 2009..For the first time genotype distribution of ApoAI and ApoB polymorphisms and their effect on lipid profile was established in Tamilians. Only -75G/A polymorphism of ApoAI was significantly associated with HDL7ndash;C levels...
- Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replicationDaniel I Chasman
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Circ Cardiovasc Genet 1:21-30. 2008....
- Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean womenSergio Baez
Division of Social and Environmental Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
World J Gastroenterol 16:372-8. 2010..To determine the effects of genetic variants associated with gallstone formation and capsaicin (a pungent component of chili pepper) metabolism on the risk of gallbladder cancer (GBC)...
- Mutation detection rate and spectrum in familial hypercholesterolaemia patients in the UK pilot cascade projectA Taylor
Great Ormond Street Hospital for Children, London, UK
Clin Genet 77:572-80. 2010..Even in subjects with a low clinical suspicion of FH, and in those of Indian origin, mutation testing has an acceptable detection rate...
- Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study dataLi Ma
Department of Animal Science, University of Minnesota, USA
BMC Med Genet 11:55. 2010..Here, we report single-locus and epistasis SNP effects on TC and HDL-C using the Framingham Heart Study (FHS) data...
- ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone diseaseJaime Sánchez-Cuén
División de Gastroenterología, Hospital Regional ISSSTE, Culiacan, Sinaloa 80230, Mexico
World J Gastroenterol 16:4685-90. 2010..To determine the possible association of the ApoB-100 (XbaI), ApoE (HhaI) and CYP7A1 (BsaI) gene polymorphisms, with the development of cholesterol gallstone disease (GD) in a Mexican population...
- Non-HDL-cholesterol as valid surrogate to apolipoprotein B100 measurement in diabetes: Discriminant Ratio and unbiased equivalenceMichel P Hermans
Endocrinology and Nutrition Unit, Universite Catholique de Louvain, 10 Avenue Hippocrate, Brussels 1200, Belgium
Cardiovasc Diabetol 10:20. 2011..Non-HDL-C represents a simple surrogate for apoB in hypertriglyceridemic and/or T2DM patients. ApoB and non-HDL-C show high correlation, although the degree of mutual concordance remains debated in CV risk evaluation...
- Validation of human ApoB and ApoAI immunoturbidity assays for non-human primate dyslipidemia and atherosclerosis researchZhu Chen
Atherosclerosis, Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA
J Cardiovasc Transl Res 4:373-83. 2011Emerging evidence suggests apolipoprotein B (apoB) and apolipoprotein AI (apoAI) are strong risk predictors for atherosclerosis...
- Polymorphism of the apolipoprotein B gene and association with plasma lipid and lipoprotein levels in the Mongolian BuryatKenji Tsunoda
Department of Legal Medicine, Showa University School of Medicine, Tokyo, Japan
Biochem Genet 50:249-68. 2012Allele frequencies at six RFLP sites (Ins/Del, ApaLI, AluI, XbaI, MspI, and EcoRI) of the apolipoprotein B gene (APOB) and the relationship of genotypes with plasma lipid and lipoprotein levels in the Mongolian Buryat were investigated...
- Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adultsDong Sik Cho
Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108, Pyung Dong, Seoul, Jongro Ku 110 746, Republic of Korea
Cardiovasc Diabetol 11:55. 2012..b>Apolipoprotein B (apo B) is the major apolipoprotein contained within atherogenic lipoproteins such as LDL, and apo B is a ..
- Polymorphisms XbaI (rs693) and EcoRI (rs1042031) of the ApoB gene are associated with carotid plaques but not with carotid intima-media thickness in patients with diabetes mellitus type 2Jovana Nikolajević Starčević
Institute of Histology and Embryology, Medical Faculty, University of Ljubljana, Slovenia
Vasa 43:171-80. 2014b>Apolipoprotein B is a key structural component of all the atherogenic lipoproteins (LDL, VLDL and IDL). Genetic variations of the ApoB gene may affect plasma ApoB and lipid levels, thus influencing atherogenesis...
- The relationship of molecular genetic to clinical diagnosis of familial hypercholesterolemia in a Danish populationDorte Damgaard
Department of Medicine and Cardiology, Aarhus Sygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
Atherosclerosis 180:155-60. 2005....
- Population genetic analysis of the genes APOE, APOB(3'VNTR) and ACE in some black and Amerindian communities from ColombiaJ P Jaramillo-Correa
Departamento de Ciencias Biologicas, Facultad de Ciencias, Universidad de Los Andes, Colombia
Hum Hered 52:14-33. 2001..This fact was not observed among the Afrocolombian populations. Nevertheless, an isolation-by-distance Slatkin analysis test did not show a significant clear structure of this special pattern among the Indian tribes studied...
- Five polymorphisms of the apolipoprotein B gene in healthy BulgariansAnelia Horvath
Department of Chemistry and Biochemistry, Medical University of Sofia, Bulgaria
Hum Biol 75:69-80. 2003..The major differences in the allele-size distributions are in the frequencies of alleles *31, *39, and *47...
- Polymorphisms in the apolipoprotein B-100 gene: association with plasma lipid concentration and coronary artery diseaseRatna Dua Puri
Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
Indian Heart J 55:60-4. 2003The aim of this study was to investigate the association of apolipoprotein B gene polymorphisms with coronary artery disease and lipid levels in Indians.
- Apolipoprotein B 3'-VNTR polymorphism in Eastern European populationsDmitry A Verbenko
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia
Eur J Hum Genet 11:444-51. 2003b>Apolipoprotein B 3' (3' ApoB) minisatellite polymorphism was studied in healthy unrelated individuals from the Russian Federation and the Republic of Belarus, in 10 populations from five ethnic groups: Russians, Byelorussians, Adygeis, ..
- [Relationship between apolipoprotein E and apolipoprotein B polymorphisms in youths with coronary heart disease]Sha Li
Dongshan People s Hospital of Guangzhou, Guangzhou, Guangdong, 510080PR China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:241-3. 2003..To investigate hereditary susceptibility to coronary heart disease (CHD) in apolipoprotein E(apo E) and apo B polymorphisms of youths...
- [VNTR3' polymorphism of apoliproprotein B gene in obese people]R Jemaa
Laboratoire de Biochimie, Hopital La Rabta, 1007 Jabbari Tunis, Tunisie
Ann Biol Clin (Paris) 60:559-64. 2002b>Apolipoprotein B (apo B) is the major component of LDL, VLDL and chylomicrons. Variations of lipid concentrations in obese people result from obesity, nutritional and genetic factors...
- Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOBBernard Khoo
Endocrinology, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
BMC Mol Biol 8:3. 2007b>Apolipoprotein B (APOB) is an integral part of the LDL, VLDL, IDL, Lp(a) and chylomicron lipoprotein particles. The APOB pre-mRNA consists of 29 constitutively-spliced exons...
- Common and rare alleles in apolipoprotein B contribute to plasma levels of low-density lipoprotein cholesterol in the general populationMarianne Benn
Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
J Clin Endocrinol Metab 93:1038-45. 2008We have previously shown that rare mutations in the apolipoprotein B gene (APOB) may result in not only severe hypercholesterolemia and ischemic heart disease but also hypocholesterolemia...
- Common genetic variants that relate to disorders of lipid transport in Spanish subjects with premature coronary artery diseaseL Masana
Servei de Medicina Interna de Reus C, St Llorenc s n 43201, Reus, Spain
Clin Sci (Lond) 100:183-90. 2001..05) and the triacylglycerol/HDL ratio (P<0.01). Only the three-codon insertion/deletion variants of the apolipoprotein B signal peptide region discriminated between the two groups with or without arterial disease (P=0.02)...
- Amiodarone-induced changes in lipid metabolismS E Kasim
Harper Hospital, Wayne State University, Detroit, Michigan
Horm Metab Res 22:385-8. 1990..61 +/- 0.26, 6 weeks 3.36 +/- 0.21 mmol/l, P less than 0.05) and in apolipoprotein B (baseline 1.95 +/- 0.15, 6 weeks 2.26 +/- 0.13 mmol/l, P less than 0.01) concentrations...
- Long-term effects of simvastatin in hypercholesterolemic patients with NIDDM and additional atherosclerotic risk factors. Hyogo Simvastatin Study GroupT Kazumi
Department of Medicine, Hyogo Medical Center for Adults, Akashi, Japan
Horm Metab Res 27:239-43. 1995..Simvastatin produced beneficial effects on serum lipids and apolipoproteins and neutral effects on glycemic control in hypercholesterolemic patients with NIDDM, whether or not they had an additional atherosclerotic risk factor...
- Screening and identification of familial defective apolipoprotein B-100 in clinical samples by capillary gel electrophoresisR Lehmann
, Innere Medizin Abteilung IV, Germany
J Chromatogr A 744:187-94. 1996Familial defective apolipoprotein B-100 (FDB) is a dominantly inherited disorder...
- Plasma lipoprotein (a) levels in Turkish NIDDM patients with and without vascular diabetic complicationsC Erem
Karadeniz Technical University Faculty of Medicine, Department of Internal Medicine, Trabzon, Turkey
Acta Cardiol 54:203-7. 1999..05). There were significant correlations between plasma log Lp(a) levels and apolipoprotein B (apo B) in all NIDDM patients (r: 0.68, p < 0.05)...
- Does alpha-1-proteinase inhibitor play a protective role in coronary atherosclerosis?D Stakisaitis
Vilnius University Medical Faculty, Vilnius, Lithuania
Med Sci Monit 7:701-11. 2001..alpha-1-proteinase inhibitor (alpha-1-PI) might appear to be actively involved in atherogenesis as an important regulator protecting elastic tissue from damage by proteinases as well as lipid accumulation in arterial wall...
- Potent and selective PPAR-alpha agonist LY518674 upregulates both ApoA-I production and catabolism in human subjects with the metabolic syndromeJohn S Millar
Departments of Pharmacology, University of Pennsylvania, 652 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
Arterioscler Thromb Vasc Biol 29:140-6. 2009..We sought to determine the effect of a potent and highly specific PPAR-alpha agonist, LY518674, on apoA-I, apoA-II, and apoB-100 kinetics in humans with metabolic syndrome and low levels of HDL cholesterol (C)...
- High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fatal myocardial infarction (AMORIS study): a prospective studyG Walldius
Astra Zeneca, Mölndal and King Gustaf V Research Institute, Karolinska Institute, Stockholm, Sweden
Lancet 358:2026-33. 2001b>Apolipoprotein B (apoB) and apolipoprotein A-I (apoA-I) are thought to be better predictors of acute myocardial infarction than total cholesterol and LDL-cholesterol...
- Usefulness of apolipoprotein B/apolipoprotein A-I ratio to predict coronary artery disease independent of the metabolic syndrome in African AmericansByambaa Enkhmaa
Department of Medicine, University of California, Davis, Sacramento, USA
Am J Cardiol 106:1264-9. 2010Studies have demonstrated that the apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio predicts cardiovascular risk better than any of the cholesterol indexes...
- Plasma apo/lipoproteins disturbances as a precondition for metabolic syndrome in HCV seronegative heroin addictsZanina Jovan Pereska
University Clinic of Toxicology, Skopje, The Former Yugoslav Republic of Macedonia
Am J Drug Alcohol Abuse 37:196-202. 2011..Dyslipidemia in heroin addicts is considered to be a precondition for developing metabolic syndrome...
- Moderate dietary salt restriction does not alter insulin resistance or serum lipids in normal menA Grey
Department of Endocrinology, Auckland Hospital, New Zealand
Am J Hypertens 9:317-22. 1996..cholesterol, high density lipoprotein cholesterol or its subfractions, triglycerides, apolipoprotein A1, or apolipoprotein B between the high salt and low salt periods...
- The effect of alendronate sodium on carotid artery intima-media thickness and lipid profile in women with postmenopausal osteoporosisMurat Celiloglu
Departments of 1Obstetrics and Gynecology and 2Radiology, Dokuz Eylul University Medical Faculty, Izmir, Turkey
Menopause 16:689-93. 2009..used in the treatment of osteoporosis, on carotid artery intima-media thickness (IMT), the lipid profile, and apolipoprotein A-I (ApoA-I) and apolipoprotein B (ApoB) levels, which are known to have a role in the atherosclerotic process.
- ApoB but not LDL-cholesterol is reduced by exercise training in overweight healthy men. Results from the 1-year randomized Oslo Diet and Exercise StudyI Holme
Department of Sports Medicine, Norwegian School of Sports Sciences, Oslo, Norway
J Intern Med 262:235-43. 2007....
- Binding of apoB-containing lipoproteins from unfractionated human blood sera to immobilized LDL receptorV V Yakushkin
Institute of Experimental Cardiology, Russian Cardiology Complex, Moscow, 121552, Russia
Biochemistry (Mosc) 63:1164-71. 1998..The results indicate that the different binding of apoB-containing lipoproteins to the immobilized LDL receptor mainly depended on the different binding of VLDL and not of LDL...
- Apolipoprotein B/apolipoprotein A-I in relation to the metabolic syndrome and change in carotid artery intima-media thickness during 3 years in middle-aged menKarin Wallenfeldt
Institute of Internal Medicine, Sahlgrenska University Hospital, Gothenburg University, Gothenburg, Sweden
Stroke 35:2248-52. 2004The apolipoprotein B (apoB)/apolipoprotein A-I (apoA-I) ratio is a measure of the relationship between different lipoprotein particles and a powerful predictor of coronary death...
- Stroke mortality and the apoB/apoA-I ratio: results of the AMORIS prospective studyG Walldius
King Gustaf V Research Institute, Karolinska Institute, Stockholm, Sweden
J Intern Med 259:259-66. 2006....
- Errors that result from using the TC/HDL C ratio rather than the apoB/apoA-I ratio to identify the lipoprotein-related risk of vascular diseaseA D Sniderman
Mike Rosenbloom Laboratory for Cardiovascular Research, Royal Victoria Hospital, Montreal, Quebec, Canada
J Intern Med 259:455-61. 2006..0%. Thus, using the conventional cholesterol ratios rather than the apoB/apoA-I ratio results in frequent and substantial error in the estimation of the lipoprotein-related risk of vascular disease...
- [Decrease ApoB/ApoA-1 ratio and cardiovascular risk improvement: a tadalafil pleiotropic effect? Preliminary study on healthy volunteers]T Roumeguere
Laboratoire de Medecine Experimentale, unité 222, CHU Charleroi, Universite Libre de Bruxelles, Montigny le Tilleul, Belgique
Prog Urol 18:1087-91. 2008..Cardiac risk assessment may deserve measurement of Apolipoprotein B/Apolipoprotein A-1 ratio. An elevated ApoB/ApoA-1 ratio is a risk factor for future coronary artery disease...
- Temporal discrepancies in the association between the apoB/apoA-I ratio and mortality in incident dialysis patientsM Chmielewski
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
J Intern Med 265:708-16. 2009..In the general population, a high apoB/apoA-I ratio is a strong risk factor for cardiovascular disease and mortality. However, whether this is the case in chronic kidney disease (CKD) patients is currently unknown...
- The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controlsSarah Parish
Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford OX3 7LF, UK
Eur Heart J 30:2137-46. 2009Plasma levels of apolipoprotein B (apoB), the main surface protein on LDL particles, and LDL-C, the amount of cholesterol in those particles, are closely correlated and, considered separately, are positive risk factors...
- Long-term efficacy and tolerability of pravastatin in hypercholesterolemia in patients with non-insulin-dependent diabetes mellitus. Hyogo Pravastatin Study GroupT Kazumi
Department of Medicine, Hyogo Medical Center for Adults, Akashi, Japan
Diabetes Res Clin Pract 27:61-8. 1995..in total serum cholesterol by 19 and 20%, in low-density lipoprotein (LDL) cholesterol by 25 and 29%, in apolipoprotein B by 15 and 19% and in triglycerides by 8 and 5%, respectively...
- Effects of probucol on plasma lipids, lipoproteins and parameters of high density lipoprotein metabolismJ R Wetterau
Department of Pharmacology and Cell Biophysics, University of Cincinnati
Horm Metab Res 24:289-96. 1992..6, 15.0 and 25.7%, respectively, in response to probucol treatment. Plasma levels of apolipoprotein B and apolipoprotein A-I also decreased, while apolipoprotein A-II concentrations were unchanged...
- Transcriptional regulation of the human apolipoprotein genesV I Zannis
Section of Molecular Genetics, Whitaker Cardiovascular Institute, Departments of Medicine and Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118 239, USA
Front Biosci 6:D456-504. 2001..Understanding the transcriptional regulatory mechanism of the apolipoprotein genes may allow, in the long run, selective increase of anti-atherogenic lipoproteins and thus reduce the risk of cardiovascular disease...
- Oxidation of apolipoprotein B-100 in circulating LDL is related to LDL residence time. In vivo insights from stable-isotope studiesJ Pietzsch
Institute and Polyclinic of Clinical Metabolic Research, Technical University Dresden, Dresden, Germany
Arterioscler Thromb Vasc Biol 20:E63-7. 2000..In contrast, LDL(2) seemed to be strongly prone to direct oxidation of apoB-100 in vivo. The longer these particles linger in the circulation, the more apoB-100 Pro/Arg residues become modified...
- Apolipoproteins, cardiovascular risk and statin response in type 2 diabetes: the Collaborative Atorvastatin Diabetes Study (CARDS)V Charlton-Menys
Cardiovascular Research Group, School of Clinical and Laboratory Sciences, Core Technology Facility 3rd floor, University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK
Diabetologia 52:218-25. 2009Controversy surrounds whether the ratio of apolipoprotein B (ApoB) to apolipoprotein A-I (ApoA-I) is the best lipoprotein discriminator of CHD risk in non-diabetic populations, but the issue has never been investigated in type 2 diabetes.
- Complete phenotypic characterization of apobec-1 knockout mice with a wild-type genetic background and a human apolipoprotein B transgenic background, and restoration of apolipoprotein B mRNA editing by somatic gene transfer of Apobec-1M Nakamuta
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
J Biol Chem 271:25981-8. 1996..These experiments indicate that Apobec-1 is an essential component of the apoB mRNA editing machinery and absence of editing in the knockout animals is a direct consequence of the absence of functional Apobec-1...
- Generation of intracellular signals by low density lipoprotein is independent of the classical LDL receptorA Sachinidis
Medical Policlinic, , Germany
Am J Hypertens 4:274-9. 1991Low density lipoprotein cholesterol (LDL) and apolipoprotein B-100 (1 to 15 micrograms/mL) had no significant influence on the inositol-1,4,5-trisphosphate (InsP3) formation in vascular smooth muscle cells and fibroblasts...
- APOLIPOPROTEIN B: mRNA editing, lipoprotein assembly, and presecretory degradationN O Davidson
Departments of Medicine and Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
Annu Rev Nutr 20:169-93. 2000..Although control of lipid secretion in vivo is primarily achieved at the level of lipoprotein particle size, regulation of apoB production by presecretory degradation may be relevant in some dyslipidemic states...
- In vivo regulation of phenylalanine hydroxylation to tyrosine, studied using enrichment in apoB-100Mahroukh Rafii
Division of Gastroentrology and Nutrition, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
Am J Physiol Endocrinol Metab 294:E475-9. 2008....
- Avoiding toxicity associated with MTP ablationM Mahmood Hussain; Fiscal Year: 2013..Proposed studies may lead to new therapeutic modalities for the treatment of various disorders associated with high plasma lipids. ..
- M Mahmood Hussain; Fiscal Year: 2014..The outcomes from these studies will impact two fields of biology;lipid metabolism and circadian regulation. Novel understanding about the circadian regulation of lipid metabolism will be garnered. ..
- Nassrin Dashti; Fiscal Year: 2015..abstract_text> ..
- Shadab A Siddiqi; Fiscal Year: 2016..In preliminary studies we have identified Sar1b as the initiator of VTV budding. Further, our data show apolipoprotein B (apoB) to be the cargo selective protein on ER-VLDL...
- Gang Ren; Fiscal Year: 2016..Each LDL particle contains one molecule of apolipoprotein B-100 (apoB-100), a ligand for hepatic clearance of plasma cholesterol via LDL receptors...
- Zahid Ahmad; Fiscal Year: 2016..heterogeneous and has been associated with variants in at least three genes including LDL receptor (LDLR), apolipoprotein B-100 (APOB), and proprotein convertase subtilisin-like kexin type 9 (PCSK9)...
- Comprehensive biomarker study to capitalize on existing GWAS in 10K South AsiansDanish Saleheen; Fiscal Year: 2010..We seek support for additional blood markers to PROMIS by assaying plasma biomarkers potentially relevant to atherogenesis, plaque rupture and/or thrombosis. ..
- Kiran Musunuru; Fiscal Year: 2016..found that carriers of ANGPTL3 nonsense mutations had decreased rates of very-low-density lipoprotein (VLDL) apolipoprotein B (apoB) production and increased fractional catabolic rates for LDL apoB...
- Screens for novel compounds to correct diabetic postprandial dyslipidemiaKevin Jon Williams; Fiscal Year: 2011..The ultimate goal will be to avert the tremendous excess burden of cardiovascular disease in diabetes. ..
- Jean Marc Schwarz; Fiscal Year: 2014..A second objective is to determine the doses of HFCS that increase the absolute and proportional contributions of DNL-fatty acids to postprandial TRL. ..
- Ronald M Krauss; Fiscal Year: 2015....
- HSPGs as remnant receptors: critical role in diabetic postprandial dyslipidemiaKevin Jon Williams; Fiscal Year: 2012..The work will expand our understanding of excess cardiovascular disease in diabetes and provide novel therapeutic targets. ..
- Characterization of microRNA-lipid-HCV interactionsESPERANCE ANNE KREEK SCHAEFER; Fiscal Year: 2013..Taken together, these studies will serve to clarify the relationship between microRNA-122, HCV, and lipid metabolism and provide insights into the pathogenesis of chronic hepatitis and its related derangements, including steatosis. ..
- The altered lipid and protein metabolism of pediatric patients with HIV infectionFarook Jahoor; Fiscal Year: 2010..Knowledge gained from this project may lead to new nutritional therapies to help prevent these conditions. ..
- Sekar Kathiresan; Fiscal Year: 2015..After identifying the causal genes in families, we will test whether these genes influence risk for heart attack in the general population. ..
- Genetics of lipoprotein metabolism and CVD in CKDDANIEL JAMES RADER; Fiscal Year: 2013..abstract_text> ..
- Nutritional and Hormonal Pathways for Reduction of ApoB-lipoproteinsLi Shin Huang; Fiscal Year: 2013....
- DANIEL JAMES RADER; Fiscal Year: 2014DESCRIPTION (provided by applicant): Lipoproteins containing apolipoprotein B (apoB-LP) are important causal risk factors for coronary artery disease (CAD)...
- THOMAS STERLING SCANLAN; Fiscal Year: 2015..4) Determine the mechanism of intracellular uptake of T1AM and search for T1AM target proteins. ..
- Markers of the metabolic syndrome linking type 2 diabetes and MI in South AsiaDanish Saleheen; Fiscal Year: 2010....
- New Avenues in GPIHBP1 ResearchAnne Beigneux; Fiscal Year: 2012..abstract_text> ..
- Hyperinsulinemia, mTOR activity and plasma lipoproteinsALAN RICHARD TALL; Fiscal Year: 2012..However, the underlying mechanisms have remained poorly understood. The proposed studies should provide new insights into the regulation of VLDL secretion and LDLR levels in these conditions. ..
- Edward A Fisher; Fiscal Year: 2014..abstract_text> ..
- M Mahmood Hussain; Fiscal Year: 2016..If proven, miR-30c might serve as a potentially new therapeutic agent to treat hyperlipidemia, atherosclerosis and other related metabolic disorders. ..
- Yury Miller; Fiscal Year: 2014....
- Outcomes and Predictors in Mild Cognitive ImpairmentMary Ganguli; Fiscal Year: 2012..The Awardee will also continue to organize trainee workshops in neglected areas such as project management, principles of neuropsvcholoav for non-psvcholoaists. and scientific writing skills. ..
- Henry N Ginsberg; Fiscal Year: 2016..of insulin resistance is very common and is associated with increased assembly and secretion of atherogenic apolipoprotein B (apoB) containing lipoproteins, particularly the triglyceride (TG)-enriched very low density lipoproteins (..
- PAMELA RANEL HALL; Fiscal Year: 2015..We identified apolipoprotein B, a component of lipid metabolism, as an essential barrier to invasive S...
- STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IVRichard B Weinberg; Fiscal Year: 2010..We believe that these studies will provide new knowledge on the function of apo A-IV in the complex process of lipoprotein assembly relevant to the dietary control of atherosclerotic cardiovascular disease and obesity. ..
- IRA A TABAS; Fiscal Year: 2015..Achieving the stated objective will provide critical information for understanding how necrotic cores form and may help in the design of new therapeutic strategies to prevent the clinical progression of atherosclerotic lesions. ..
- Proteostasis Network Factors Involved in Apolipoprotein B Folding and SecretionJoseph Genereux; Fiscal Year: 2012..We will identify the factors of the proteostasis network that regulate apoB folding and processing into VLDL, and characterize the impact of these factors on VLDL secretion. ..
- Aleem Siddiqui; Fiscal Year: 2016..We further propose to investigate the mechanisms by which HCV gene expression impairs the lipidation of apolipoprotein B-100 (apoB). ApoB represents the major structural component of VLDL...
- Jean Marc Schwarz; Fiscal Year: 2016..These findings could inform efforts to develop evidence-based interventions and dietary guidance to mitigate CVD risk. ..
- AMPHIPATHIC MOTIFS, LIPOPROTEINS AND ATHEROSCLEROSISJere P Segrest; Fiscal Year: 2012..Jere P. Segrest, Project Leader). 2) Molecular mechanisms of biogenesis of apolipoprotein B-containing lipoproteins (Dr. Nassrin Dashti, Project Leader)...
- Dyslipidemia, Lipoic Acid and Diabetic Vascular Complications in HumanizedNobuyo Maeda; Fiscal Year: 2010....
- MOLECULAR MECHANISMS OF OXIDATION OF LDLSampath Parthasarathy; Fiscal Year: 1999..The applicant proposes to study mechanisms by which apolipoprotein B (apoB) and amino phospholipids (phosphatidylethanolamine) of LDL play a role in the propagation of lipid ..
- Serum amyloid P and chronic noncommunicable diseasesWeibin Shi; Fiscal Year: 2010..The proposed research offers an opportunity to assess the contribution of serum amyloid P to the development of chronic noncommunicable diseases. ..
- THOMAS STERLING SCANLAN; Fiscal Year: 2014....
- Amrita Kamat; Fiscal Year: 2016..The study is expected to have an important impact by defining new molecular targets for the prevention and/or treatment of NAFLD and its complications. ..
- Effects of amino acids on regional lipid metabolismElisabet Borsheim; Fiscal Year: 2013..The overall goal of this project is to test a novel treatment using nutrient (amino acid) supplementation against this condition in men and women, and to understand how this treatment works. ..
- Hepatic Rictor Knockout Mouse Model and the Metabolic SyndromeJENNIFER MARIE ROJAS; Fiscal Year: 2012..The possibility of hepatic steatosis will be assessed by liver lipid quantification. ..
- Henry N Ginsberg; Fiscal Year: 2014..women, Whites vs non-whites, and dyslipidemics vs non-dyslipidemics. ..
- Apo A2, C1 and C2 and Diet in human apoB MetabolismFrank Sacks; Fiscal Year: 2005..abstract_text> ..
- MACROPHAGE CHYLOMICRON/B48 RECEPTOR, BINDING MECHANISMSWilliam Bradley; Fiscal Year: 2004..abstract_text> ..
- NICHOLAS DAVIDSON; Fiscal Year: 2016..The longstanding focus of this award has been the posttranscriptional regulation of apolipoprotein B (apoB) RNA editing and the apoB isoform-specific (i.e...
- Regulation of Leukocyte Migration by PlasminogenJANE LEE HOOVER-PLOW; Fiscal Year: 2013..The objective of this proposal is to determine the mechanisms by which plasminogen regulates cell migration and, thereby, the inflammatory responses that contribute to thrombosis and CVD. ..
- Max A Cayo; Fiscal Year: 2016..abstract_text> ..
- EDITING OF APOLIPOPROTEIN-B MRNADONNA DRISCOLL; Fiscal Year: 2004..The successful pursuit of these aims should provide insight into the mechanism of apo-B mRNA editing and the function of ACF. ..
- MECHANISM OF APOLIPOPROTEIN B-48 BIOGENESISLawrence Chan; Fiscal Year: 1993..The proposed work will shed light on this process, which also has profound implications for general cell and molecular biology...
- GENETIC EPIDEMIOLOGY OF ELEVATED APOB LEVELGAIL JARVIK; Fiscal Year: 1999..Adapted from the Investigator's Abstract) The investigator's overall goal in this project is to map the apolipoprotein B elevating level (BEL) gene by doing a genomic search in pedigrees with familial combined hyperlipidemia, with ..
- Premature Aging, Vascular Disease and Endothelial MechanotransductionWILLIAM JAMES ADAMS; Fiscal Year: 2012..This will indicate whether the premature aging model endothelium is predisposed atherosclerosis due to dysfunctional mechanotransduction. ..
- Development of CNS-targeted AAV vectorsMIGUEL S ESTEVES; Fiscal Year: 2012..of CNS-targeted AAV vectors to foster the development of highly effective gene therapy approaches to treat many childhood, adult, and geriatric neurological diseases currently beyond the reach of modern medicine ..
- Targets of a cytidine deaminase required for left-right axis in XenopusAlin Vonica; Fiscal Year: 2010..Finding the genes targeted by APOBEC2 will significantly improve our knowledge of a family of proteins increasingly important in human pathology. ..
- Mechanisms of PAI-1 Induced Anti-AngiogenesisMary J Mulligan Kehoe; Fiscal Year: 2011....
- Endothelial Dysfunction, Oxidative Stress and Risk of Peripheral Arterial DiseaseKenneth Jay Mukamal; Fiscal Year: 2010..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..
- METABOLIC REGULATION OF APOLIPOPROTEIN B MRNA EDITINGHarold Smith; Fiscal Year: 2003DESCRIPTION (adapted from the applicant's description): Apolipoprotein B (apoB) is a non-exchangeable structural component of chylomicrons and of very low density (VLDL), intermediate density (IDL), and low density (LDL) lipoprotein ..
- Lipoprotein(a) and AtherosclerosisROBERT PITAS; Fiscal Year: 2007..The proposed studies will increase our understanding of the mechanisms by which Lp(a) contributes to atherogenesis and may lead to more rational means of intervention. ..
- Regulation of Apolipoprotein B SecretionALAN ATTIE; Fiscal Year: 2006..This will enable us to differentiate between an interaction with apoB early in the secretory pathway and an interaction that occurs after apoB secretion leading to re-uptake of the lipoprotein particles. ..
- INTERACTIONS OF LP(A) WITH SUBENDOTHELIAL CELL MATRIXWalter McConathy; Fiscal Year: 1993..These studies should provide a better understanding of the link between plasma lipoproteins, the hemostasis system, and the progression of atherosclerosis...
- DIABETES, LIPOPROTEINS AND ACCELERATED VASCULAR DISEASEHenry Ginsberg; Fiscal Year: 2000..This will allow for better prevention and more specific intervention in this patient population. ..
- MODELS OF ATHEROSCLEROSIS BY TARGETED GENE DUPLICATIONMYRON HINSDALE; Fiscal Year: 1999..targeting and to use these animal models to study, at the molecular level, the role of increased secretion of apolipoprotein B-containing lipoproteins on atherogenesis...
- APOB FOLDING & SECRETION--CHARACTERIZING HELPER PROTEINSHaya Herscovitz; Fiscal Year: 2000..research are to study the molecular details of the mechanisms regulating the folding and secretion of apolipoprotein B (apo B)...
- REGULATION OF APOB SECRETION IN INBRED MOUSE STRAINSLi Shin Huang; Fiscal Year: 2009Elevated plasma levels of apolipoprotein B (apo B) and low density lipoprotein (LDL) are associated with a higher risk for atherosclerotic coronary heart disease (CHD), a leading cause of mortality in the industrialized world...
- APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISMLawrence Chan; Fiscal Year: 2004..Thus, the overall project is highly relevant to lipid nutrient absorption and homeostasis. Significantly, it also provides important information on a newly described pathway in posttranscriptional gene regulation. ..
- Hepatic Steatosis Modulation by Apo B Gene TranscriptionJANET DEHOFF SPARKS; Fiscal Year: 2010....