ApoE

Summary

Gene Symbol: ApoE
Description: apolipoprotein E
Alias: AD2, APO-E, ApoE4, LDLCQ5, LPG, apolipoprotein E, apolipoprotein E3
Species: human

Top Publications

  1. ncbi Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Genet 39:17-23. 2007
  2. ncbi Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease
    Hao Li
    GlaxoSmithKline, Research Triangle Park, North Carolina, USA
    Arch Neurol 65:45-53. 2008
  3. doi Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer's disease
    Nicola Filippini
    The Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK
    Neuroimage 44:724-8. 2009
  4. ncbi Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    E H Corder
    Department of Medicine, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
    Science 261:921-3. 1993
  5. pmc Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele
    Nicola Filippini
    University Department of Psychiatry, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 106:7209-14. 2009
  6. pmc Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    Denise Harold
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 41:1088-93. 2009
  7. pmc GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers
    Eric M Reiman
    Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA
    Neuron 54:713-20. 2007
  8. pmc Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
    Chia Chen Liu
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361005, China
    Nat Rev Neurol 9:106-18. 2013
  9. ncbi Apolipoprotein E: far more than a lipid transport protein
    R W Mahley
    Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California 94141 9100, USA
    Annu Rev Genomics Hum Genet 1:507-37. 2000
  10. doi Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
    Jean Charles Lambert
    INSERM U744, Lille, France
    Nat Genet 41:1094-9. 2009

Detail Information

Publications346 found, 100 shown here

  1. ncbi Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Genet 39:17-23. 2007
    ..In addition to identifying the epsilon4 allele of APOE and related effects, we pinpointed over a dozen potential Alzheimer disease susceptibility genes (ACE, CHRNB2, CST3,..
  2. ncbi Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease
    Hao Li
    GlaxoSmithKline, Research Triangle Park, North Carolina, USA
    Arch Neurol 65:45-53. 2008
    ..To identify single-nucleotide polymorphisms (SNPs) associated with risk and age at onset of Alzheimer disease (AD) in a genomewide association study of 469 438 SNPs...
  3. doi Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer's disease
    Nicola Filippini
    The Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK
    Neuroimage 44:724-8. 2009
    b>APOE epsilon4 is the best-established genetic risk factor for sporadic Alzheimer's disease (AD)...
  4. ncbi Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    E H Corder
    Department of Medicine, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
    Science 261:921-3. 1993
    The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD)...
  5. pmc Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele
    Nicola Filippini
    University Department of Psychiatry, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 106:7209-14. 2009
    The APOE epsilon4 allele is a risk factor for late-life pathological changes that is also associated with anatomical and functional brain changes in middle-aged and elderly healthy subjects...
  6. pmc Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    Denise Harold
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 41:1088-93. 2009
    ..In stage 1 (3,941 cases and 7,848 controls), we replicated the established association with the apolipoprotein E (APOE) locus (most significant SNP, rs2075650, P = 1...
  7. pmc GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers
    Eric M Reiman
    Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA
    Neuron 54:713-20. 2007
    The apolipoprotein E (APOE) epsilon4 allele is the best established genetic risk factor for late-onset Alzheimer's disease (LOAD)...
  8. pmc Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
    Chia Chen Liu
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361005, China
    Nat Rev Neurol 9:106-18. 2013
    b>Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport and injury repair in the brain...
  9. ncbi Apolipoprotein E: far more than a lipid transport protein
    R W Mahley
    Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California 94141 9100, USA
    Annu Rev Genomics Hum Genet 1:507-37. 2000
    ..ApoE is a polymorphic protein arising from three alleles at a single gene locus. The three major isoforms, apoE4, apoE3, and apoE2, differ from one another only by single amino acid substitutions, yet these changes have ..
  10. doi Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
    Jean Charles Lambert
    INSERM U744, Lille, France
    Nat Genet 41:1094-9. 2009
    The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease...
  11. ncbi A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease
    Keith D Coon
    Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Ariz 85004, USA
    J Clin Psychiatry 68:613-8. 2007
    While the apolipoprotein E (APOE) epsilon allele is a well-established risk factor for late-onset Alzheimer's disease (AD), initial genome scans using microsatellite markers in late-onset AD failed to identify this locus on chromosome 19...
  12. ncbi Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study
    Laura Jean Podewils
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Epidemiol 161:639-51. 2005
    ..33, 0.79) compared with those engaging in 0-1 activity. These associations were more marked in apolipoprotein E genotype (APOE) epsilon4 allele noncarriers but were absent in carriers...
  13. pmc Association between apolipoprotein E gene polymorphism and the risk of coronary artery disease in Chinese population: evidence from a meta-analysis of 40 studies
    Yan Wei Yin
    Department of Emergency, Chinese PLA Air Force General Hospital, Beijing, PR China
    PLoS ONE 8:e66924. 2013
    Epidemiological studies have evaluated the association between apolipoprotein E (ApoE) gene polymorphism and coronary artery disease (CAD) risk which developed inconsistent conclusions...
  14. pmc Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
    Eric M Reiman
    Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA
    Proc Natl Acad Sci U S A 101:284-9. 2004
    ..We previously found that cognitively normal, late-middle-aged carriers of the apolipoprotein E epsilon4 allele, a common susceptibility gene for late-onset Alzheimer's dementia, have abnormally low rates ..
  15. pmc Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β
    Robert M Koffie
    Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA
    Brain 135:2155-68. 2012
    The apolipoprotein E ε4 gene is the most important genetic risk factor for sporadic Alzheimer's disease, but the link between this gene and neurodegeneration remains unclear...
  16. ncbi Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease
    Yiqing Song
    Brigham and Women s Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Ann Intern Med 141:137-47. 2004
    b>Apolipoprotein E (apoE) genotypes play critical roles in lipid metabolism and are believed to influence risk for coronary heart disease (CHD)...
  17. pmc fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease
    Mark W Bondi
    University of California San Diego and VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Neurology 64:501-8. 2005
    To determine whether APOE genotype influences brain response and whether nonverbal stimuli generate findings comparable with those of previous studies that used verbal stimuli...
  18. ncbi Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review
    June E Eichner
    Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Oklahoma City 73190, OK
    Am J Epidemiol 155:487-95. 2002
    ..examines the association between the apolipoprotein (apo) var epsilon gene polymorphism (or its protein product (apo E)), metabolic regulation of cholesterol, and cardiovascular disease...
  19. pmc Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study
    Mi Ryung Han
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Neurol 10:90. 2010
    ..common and highly heritable with many genes and gene variants associated with AD in one or more studies, including APOE ε2/ε3/ε4...
  20. doi The effects of APOE on the functional architecture of the resting brain
    Aaron J Trachtenberg
    Functional Magnetic Resonance Imaging of the Brain FMRIB Centre, University of Oxford, Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, United Kingdom
    Neuroimage 59:565-72. 2012
    There is a well-established association between APOE genotype and the risk of developing Alzheimer's disease (AD)...
  21. pmc APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42
    Yvette I Sheline
    Department of Psychiatry, The Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:17035-40. 2010
    ..Here we sought to determine if pathological effects of apolipoprotein E ε4 (APOE4) genotype could be seen independent of Aβ plaque toxicity by examining resting state fMRI ..
  22. pmc Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice
    Faith M Harris
    Gladstone Institute of Neurological Disease, San Francisco, CA 94141 9100, USA
    Proc Natl Acad Sci U S A 100:10966-71. 2003
    ..show that this fragmentation is caused by proteolysis of apoE by a chymotrypsin-like serine protease that cleaves apoE4 more efficiently than apoE3...
  23. pmc Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort
    S Kim
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street, R2 E124, Indianapolis, IN 46202, USA
    Neurology 76:69-79. 2011
    ..We report a genome-wide association study (GWAS) of CSF biomarkers (Aβ1-42, t-tau, p-tau181p, p-tau181p/Aβ1-42, and t-tau/Aβ1-42)...
  24. doi A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals
    Almut Nebel
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Mech Ageing Dev 132:324-30. 2011
    ..which was replicated in an independent German sample, is fully explicable by linkage disequilibrium with the APOE allele ɛ4, the only variant hitherto established as a major genetic determinant of survival into old age...
  25. ncbi The epsilon2 and epsilon4 alleles of the apolipoprotein gene are associated with age-related macular degeneration
    Paul N Baird
    Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 45:1311-5. 2004
    ..of all the genes studied in relation to age-related macular degeneration (AMD), the alleles of the apolipoprotein (apoE) gene have been the most consistently associated with disease...
  26. doi Genetic influences on Alzheimer's disease: evidence of interactions between the genes APOE, APOC1 and ACE in a sample population from the South of Brazil
    Juliana Fagion Lucatelli
    Health Science Institute, Pró Reitoria de Pesquisa e Inovação, PROPI Sala 201 F, Universidade Feevale, RS 239, No 2755, B Vila Nova, Novo Hamburgo, RS, 93352 000, Brazil
    Neurochem Res 36:1533-9. 2011
    ..Several genes have been suggested as Alzheimer's susceptibility factors, the apolipoprotein E (APOE) gene being an established susceptibility gene and the genes coding angiotensin-converting enzyme (ACE) ..
  27. pmc Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study
    Douglas C Dean
    Advanced Baby Imaging Lab, School of Engineering, Brown University, Providence, Rhode Island
    JAMA Neurol 71:11-22. 2014
    ..Early detection of these alterations holds inherent value for the development and evaluation of preventive treatment therapies...
  28. ncbi APOE genotype and cognitive decline in a middle-aged cohort
    C K Blair
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
    Neurology 64:268-76. 2005
    Most longitudinal studies of nondemented persons have reported greater cognitive decline among APOE epsilon4 carriers vs noncarriers...
  29. pmc Apolipoprotein gene polymorphisms and plasma levels in healthy Tunisians and patients with coronary artery disease
    Raoudha Bahri
    Laboratoire de Génétique Humaine, Faculté de Pharmacie de Monastir, Université de Monastir 5000 Monastir, Tunisia
    Lipids Health Dis 7:46. 2008
    ..To analyze apolipoprotein gene polymorphisms in the Tunisian population and to check the relation of these polymorphisms and homocysteine, lipid and apolipoprotein levels to the coronary artery disease (CAD)...
  30. doi Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles
    Wagane J A Benga
    Institut National de la Santé et de la Recherche Médicale INSERM Unite 748, Strasbourg, France
    Hepatology 51:43-53. 2010
    ..Using a yeast-two-hybrid system, we identified apolipoprotein E (apoE) as a liver-derived host factor specifically interacting with HCV nonstructural protein 5A (NS5A) but ..
  31. ncbi Apolipoprotein E: cholesterol transport protein with expanding role in cell biology
    R W Mahley
    Gladstone Foundation Laboratories for Cardiovascular Disease, University of California, San Francisco 94140 0608
    Science 240:622-30. 1988
    b>Apolipoprotein E is a plasma protein that serves as a ligand for low density lipoprotein receptors and, through its interaction with these receptors, participates in the transport of cholesterol and other lipids among various cells of the ..
  32. doi Differential effects of the APOE genotype on brain function across the lifespan
    N Filippini
    University Department of Psychiatry, University of Oxford, Oxford, UK
    Neuroimage 54:602-10. 2011
    Increasing age and carrying an APOE ε4 allele are well established risk factors for Alzheimer's disease (AD). The earlier age of onset of AD observed in ε4-carriers may reflect an accelerated aging process...
  33. pmc Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
    Joris Deelen
    Section of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Aging Cell 10:686-98. 2011
    ..65-0.77), P=3.39 × 10(-17) ]. This SNP, rs2075650, is located in TOMM40 at chromosome 19q13.32 close to the apolipoprotein E (APOE) gene...
  34. doi Examination of the current top candidate genes for AD in a genome-wide association study
    T M Feulner
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universität München TUM, Munich, Germany
    Mol Psychiatry 15:756-66. 2010
    ..In addition to the apolipoprotein E locus, we identified nominally significant association signals in six of the ten genes investigated, albeit ..
  35. doi APOE E4 status predicts age-related cognitive decline in the ninth decade: longitudinal follow-up of the Lothian Birth Cohort 1921
    O J G Schiepers
    School for Mental Health and Neuroscience MHeNS European Graduate School of Neuroscience Euron, Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
    Mol Psychiatry 17:315-24. 2012
    Carriers of the APOE E4 allele have an increased risk of developing Alzheimer's disease. However, it is less clear whether APOE E4 status may also be involved in non-pathological cognitive ageing...
  36. pmc MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers
    N Schuff
    Department of Veterans Affairs Medical Center, San Francisco, CA, USA
    Brain 132:1067-77. 2009
    ..Disease Neuroimaging Initiative (ADNI); (ii) to determine the extent to which the polymorphism of the apolipoprotein E (ApoE) gene modulates hippocampal change; and (iii) to determine if rates of hippocampal loss correlate with ..
  37. pmc APOE genotype alters glial activation and loss of synaptic markers in mice
    Yuangui Zhu
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Glia 60:559-69. 2012
    The ε4 allele of the Apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), and affects clinical outcomes of chronic and acute brain damages...
  38. pmc A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease
    A D Roses
    Department of Medicine, Duke University, Durham, NC 27708 0120, USA
    Pharmacogenomics J 10:375-84. 2010
    The ɛ4 allele of the apolipoprotein E (APOE) gene is currently the strongest and most highly replicated genetic factor for risk and age of onset of late-onset Alzheimer's disease (LOAD)...
  39. pmc ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo
    Sonya B Dumanis
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    J Neurosci 29:15317-22. 2009
    The three human alleles of apolipoprotein E (APOE) differentially influence outcome after CNS injury and affect one's risk of developing Alzheimer's disease (AD)...
  40. pmc Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele
    David G Cook
    Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Pathol 162:313-9. 2003
    ..shown that AD patients exhibit abnormalities in insulin metabolism that are associated with apoliprotein E (APOE) status...
  41. ncbi MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET
    L Mosconi
    Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Neurology 63:2332-40. 2004
    To investigate whether the combination of fluoro-2-deoxy-d-glucose (FDG) PET measures with the APOE genotype would improve prediction of the conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD).
  42. doi Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age
    Eloise Kok
    Department of Forensic Medicine, Medical School, University of Tampere, Tampere, Finland
    Ann Neurol 65:650-7. 2009
    ..age dependency of senile plaques (SP) and neurofibrillary tangles (NFT), the brain changes characteristic of Alzheimer disease (AD), and their association with apolipoprotein E (APOE) genotypes in a community-dwelling normal population.
  43. pmc Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers
    A C Burggren
    David Geffen School of Medicine at UCLA, Center for Cognitive Neurosciences, Semel Institute, 760 Westwood Plaza B8 169, Los Angeles, CA 90095, USA
    Neuroimage 41:1177-83. 2008
    Our objective was to investigate whether asymptomatic carriers of apolipoprotein E epsilon4 [APOE-4] demonstrate pathological differences and atrophy in medial temporal lobe (MTL) subregions...
  44. pmc Apolipoprotein E, not fibrillar β-amyloid, reduces cerebral glucose metabolism in normal aging
    William J Jagust
    Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, California 94720 3190, USA
    J Neurosci 32:18227-33. 2012
    The ε4 allele of the polymorphic apolipoprotein E gene is associated with increased risk of Alzheimer's disease (AD), deposition of β-amyloid (Aβ), and reduction in cerebral glucose metabolism in asymptomatic people...
  45. pmc APOE ε4 increases risk for dementia in pure synucleinopathies
    Debby Tsuang
    Veterans Affairs Puget Sound Health Care System, Seattle, WA98108, USA
    JAMA Neurol 70:223-8. 2013
    To test for an association between the apolipoprotein E (APOE) ϵ4 allele and dementias with synucleinopathy.
  46. ncbi Lipid-related genes and myocardial infarction in 4685 cases and 3460 controls: discrepancies between genotype, blood lipid concentrations, and coronary disease risk
    Bernard Keavney
    Institute of Human Genetics, University of Newcastle upon Tyne, UK
    Int J Epidemiol 33:1002-13. 2004
    ..Various associations between CHD risk and genes that moderately affect plasma lipid levels have been described, but previous studies have typically involved too few 'cases' to assess these associations reliably...
  47. doi APOE genotype influences triglyceride and C-reactive protein responses to altered dietary fat intake in UK adults
    Andrew L Carvalho-Wells
    Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, Department of Food and Nutritional Sciences, University of Reading, Reading, United Kingdom
    Am J Clin Nutr 96:1447-53. 2012
    The response of plasma lipids to dietary fat manipulation is highly heterogeneous, with some indications that APOE genotype may be important.
  48. pmc The role of lipid-related genes, aging-related processes, and environment in healthspan
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Trent Hall, Room 002, Box 90408, Durham, NC 27708, USA
    Aging Cell 12:237-46. 2013
    ..environments can substantially impact the role of lipid-related genes discovered in candidate gene (the apolipoprotein E (APOE) e2/3/4 polymorphism) and genome-wide (the APOB rs1042034 (C/T)) studies, in regulation of total ..
  49. pmc Does apolipoprotein E polymorphism influence susceptibility to malaria?
    M A Wozniak
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, UMIST, Manchester, UK
    J Med Genet 40:348-51. 2003
    ..infection varies greatly among people, and in the case of three very different viruses, it is determined by apolipoprotein E (APOE) genotype...
  50. ncbi Apolipoprotein E expression in localized prostate cancers
    Marco C Venanzoni
    Laboratory of Molecular Oncology, Laboratory Medicine Department, INRCA, I Ancona 60100, Italy
    Int J Oncol 22:779-86. 2003
    ..b>ApoE mRNA was found to be highly expressed only in PC-3 cell-line...
  51. pmc APOE genotype modifies the association between plasma omega-3 fatty acids and plasma lipids in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Shuang Liang
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Atherosclerosis 228:181-7. 2013
    ..acids (DHA) on plasma lipid profiles have been inconsistent but may partially depend on individual Apolipoprotein E (APOE) genotypes...
  52. pmc Association between APOE, SCARB1, PPARα polymorphisms and serum lipids in a population of Lithuanian adults
    Alina Smalinskiene
    Laboratory of Molecular Cardiology, Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
    Lipids Health Dis 12:120. 2013
    ..The objective of this study was to assess the distribution of the APOE, SCARB1, PPARα genotypes in the Lithuanian adult population and to determine the relationship of these genotypes ..
  53. pmc ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling
    Ying Chen
    Department of Molecular Genetics, Center for Alzheimer s and Neurodegenerative Disease, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 107:12011-6. 2010
    b>Apolipoprotein E (ApoE) genotype is a powerful genetic modifier of Alzheimer's disease (AD). The ApoE4 isoform significantly reduces the mean age-of-onset of dementia through unknown mechanisms...
  54. doi Effects of APOE on brain white matter microstructure in healthy adults
    Lars T Westlye
    Department of Psychology, Center for the Study of Human Cognition, University of Oslo, Oslo, Norway
    Neurology 79:1961-9. 2012
    b>APOE is related to cholesterol transport and clearance and brain white matter (WM) properties involving myelin, of which cholesterol is a major component...
  55. pmc Apolipoprotein E and familial longevity
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Neurobiol Aging 34:1287-91. 2013
    Exceptional longevity is associated with substantial heritability. The ε4 allele in apolipoprotein E and the linked G allele in rs2075650 of TOMM40 have been associated with increased mortality and the ε2 allele with decreased mortality,..
  56. pmc Lack of association of apolipoprotein E (Apo E) ε2/ε3/ε4 polymorphisms with primary open-angle glaucoma: a meta-analysis from 1916 cases and 1756 controls
    Wei Wang
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat Sen University, Guangzhou, People s Republic of China
    PLoS ONE 8:e72644. 2013
    A number of case-control studies were conducted to investigate the association of apolipoprotein E (Apo E) polymorphisms with primary open angle glaucoma (POAG). But the results remain controversial...
  57. pmc APOE and Alzheimer disease: a major gene with semi-dominant inheritance
    E Genin
    Inserm UMRS 946, Paris, France
    Mol Psychiatry 16:903-7. 2011
    b>Apolipoprotein E (APOE) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are currently not accurately known and odds ratios alone are insufficient to assess these risks...
  58. doi The apolipoprotein E ε4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase
    Taher Darreh-Shori
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Sweden
    Neurobiol Aging 32:1236-48. 2011
    The apolipoprotein E (ApoE) ε4 allele has consistently been established as an Alzheimer's disease (AD) risk factor, but its pathological contribution to AD is obscure...
  59. ncbi Associations between apoE genotype and colon and rectal cancer
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, UT 84108, USA
    Carcinogenesis 26:1422-9. 2005
    b>Apolipoprotein E (apoE) plays a major role in the metabolism of bile acids, cholesterol and triglycerides, and has recently been proposed as being involved in the carcinogenic process...
  60. ncbi Apolipoprotein E gene polymorphism and allele frequencies in the Lebanese population
    Rami A R Mahfouz
    Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Riad El Solh, 1107 2020, P O Box 11 0236, Beirut, Lebanon
    Mol Biol Rep 33:145-9. 2006
    b>Apolipoprotein E (ApoE) genotypes were studied in order to determine the prevalence in the Lebanese population and compare it with other populations. DNA from 160 unrelated healthy donors from our HLA-bank was used...
  61. doi Distribution of APOE genotypes in a memory clinic cohort
    W M van der Flier
    Alzheimer Center, Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 25:433-8. 2008
    To describe the distribution of apolipoprotein E (APOE) genotypes in a cohort of memory clinic patients.
  62. ncbi Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study
    C Lahoz
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Atherosclerosis 154:529-37. 2001
    ..The apo E4 (Arg112-Cys) polymorphism has been associated with dementia and hypercholesterolemia. We investigated the relation of APOE genotype to cardiovascular disease (CVD) in the Framingham Offspring Study.
  63. ncbi Human apolipoprotein E. The complete amino acid sequence
    S C Rall
    J Biol Chem 257:4171-8. 1982
  64. pmc Amyloid load in nondemented brains correlates with APOE e4
    Richard J Caselli
    Department of Neurology, Mayo Clinic Arizona, 13400 East Shea Blvd, Scottsdale, AZ 85259, United States
    Neurosci Lett 473:168-71. 2010
    ..CAA), and neurofibrillary tangle (NFT) density scores were based on CERAD criteria and compared in apolipoprotein E (APOE) e4 carriers (n=42) and noncarriers (NC) (n=137). Mean age (83.4+/-...
  65. doi The interleukin-6 gene -572C/G promoter polymorphism modifies Alzheimer's risk in APOE epsilon 4 carriers
    Min Wang
    Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, PR China
    Neurosci Lett 482:260-3. 2010
    ..Definitive genotyping of these markers and apolipoprotein E (APOE) polymorphism were surveyed in 341 SAD patients and 421 controls...
  66. pmc Multilocus analysis of age-related macular degeneration
    Julie Bergeron-Sawitzke
    SAIC Frederick, Basic Science Program, Human Genetics Section, Frederick, MD 21702 1201, USA
    Eur J Hum Genet 17:1190-9. 2009
    ..factor B (CFB), age-related maculopathy susceptibility (ARMS2), HtrA serine peptidase 1 (HTRA1), and apolipoprotein E (APOE)...
  67. doi Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults
    Tanja Richter-Schmidinger
    Department of Psychiatry and Psychotherapy, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    J Neural Transm (Vienna) 118:249-57. 2011
    Unravelling the impact of genetic variants on clinical phenotypes is a challenging task. Apolipoprotein E (ApoE) and brain-derived neurotrophic factor (BDNF) play an important role in cell growth, regeneration, synaptic plasticity, ..
  68. ncbi An association study of 43 SNPs in 16 candidate genes with atorvastatin response
    J F Thompson
    Discovery Pharmacogenomics, Pfizer Global Research and Development, Eastern Point Road, MS8118D 3069, Groton, CT 06340, USA
    Pharmacogenomics J 5:352-8. 2005
    ..The magnitude of all the differences found is sufficiently small that genetic data from these genes should not influence clinical decisions on statin administration...
  69. ncbi Apolipoprotein E polymorphism in cerebrovascular & coronary heart diseases
    Shajith Anoop
    Department of Environmental Sciences, Bharathiar University, Coimbatore, India
    Indian J Med Res 132:363-78. 2010
    The role of apolipoprotein E (apo E) in lipid metabolism and cholesterol transport is well established. About 14 per cent of the variation in plasma cholesterol levels is attributed to polymorphisms in APO E gene (APO E)...
  70. pmc Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci
    Joseph H Lee
    Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Neurol 65:1518-26. 2008
    ..To identify putative genetic loci related to the risk of late-onset Alzheimer disease (LOAD)...
  71. ncbi Apolipoprotein E polymorphism--a risk factor for metabolic syndrome
    Anca Sima
    Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    Clin Chem Lab Med 45:1149-53. 2007
    ..The aim of this study was to determine the association between apolipoprotein E (apoE) genotypes and the risk of metabolic syndrome and/or coronary heart disease complications.
  72. doi APOE gene polymorphisms and response to statin therapy
    E Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Pharmacogenomics J 9:248-57. 2009
    Published studies investigating the role of APOE gene on lipid response (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides) to statin treatment have ..
  73. doi Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease
    A Drzezga
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technischen Universitat Munchen, Ismaninger Str 22, D 81675 München Munich, Germany
    Neurology 72:1487-94. 2009
    To examine the influence of the APOE genotype on levels of beta-amyloid (Abeta) plaque load and atrophy in patients with Alzheimer disease (AD) in vivo.
  74. pmc Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
    Rita P S Middelberg
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    BMC Med Genet 12:123. 2011
    ....
  75. pmc Comprehensive search for Alzheimer disease susceptibility loci in the APOE region
    Gyungah Jun
    Department of Medicine Biomedical Genetics, Boston University Schools of Medicine and Public Health, Boston, MA, USA
    Arch Neurol 69:1270-9. 2012
    ..of risk and age at onset (AAO) of Alzheimer disease (AD) with single-nucleotide polymorphisms (SNPs) in the chromosome 19 region including apolipoprotein E (APOE) and a repeat-length polymorphism in TOMM40 (poly-T, rs10524523).
  76. doi Meta-analysis of APOE4 allele and outcome after traumatic brain injury
    Weidong Zhou
    Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
    J Neurotrauma 25:279-90. 2008
    There is conflicting evidence regarding a possible association between the apolipoprotein E4 (APOE4) allele and the consequences of traumatic brain injury (TBI)...
  77. pmc Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA
    PLoS ONE 4:e6501. 2009
    With the exception of APOE epsilon4 allele, the common genetic risk factors for sporadic Alzheimer's Disease (AD) are unknown.
  78. pmc A meta-analysis of apolipoprotein E gene ε2/ε3/ε4 polymorphism for gallbladder stone disease
    Pei Xue
    Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 7:e45849. 2012
    ..This meta-analysis aims to comprehensively evaluate the influence of a common ε2/ε3/ε4 polymorphism in Apo E gene on the risk of gallbladder stone disease.
  79. ncbi Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD?
    J Persson
    Department of Psychology, Umea University, S 901 87 Umea, Sweden
    Neurology 66:1029-33. 2006
    Previous research has shown that polymorphisms of apolipoprotein E (APOE) represent genetic risk factors for dementia and for cognitive impairment in the elderly...
  80. ncbi Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele
    Heather A Wishart
    Neuropsychology Program and Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School DHMC, One Medical Center Dr, Lebanon, NH 03756 0001, USA
    Am J Psychiatry 163:1603-10. 2006
    ..The purpose of this study was to determine whether brain activation patterns associated with working memory differ as a function of apolipoprotein E (APOE) genotype in cognitively intact adults.
  81. doi Worldwide allele frequencies of the human apolipoprotein E gene: climate, local adaptations, and evolutionary history
    Dan T A Eisenberg
    Department of Anthropology, Northwestern University, Evanston, IL 60208, USA
    Am J Phys Anthropol 143:100-11. 2010
    The epsilon4 allele of the apolipoprotein E (APOE) gene is associated with increased cholesterol levels and heart disease...
  82. doi The APOE ɛ4 allele modulates brain white matter integrity in healthy adults
    V Heise
    Department of Psychiatry, University of Oxford, Oxford, UK
    Mol Psychiatry 16:908-16. 2011
    The Apolipoprotein E (APOE) ɛ4 allele is the best-established genetic risk factor for sporadic Alzheimer's disease, and is also associated with structural gray matter and functional brain changes in healthy young, middle-aged and elderly ..
  83. pmc Temporal lobe functional activity and connectivity in young adult APOE varepsilon4 carriers
    Nancy A Dennis
    Center for Cognitive Neuroscience, Duke University, Durham, NC, USA
    Alzheimers Dement 6:303-11. 2010
    We sought to determine if the APOE epsilon4 allele influences both the functional activation and connectivity of the medial temporal lobes (MTLs) during successful memory encoding in young adults.
  84. pmc Semantic memory activation in individuals at risk for developing Alzheimer disease
    M Seidenberg
    Department of Psychology, Rosalind Franklin University of Medicine and Science, Chicago, IL, USA
    Neurology 73:612-20. 2009
    ..event-related fMRI can distinguish healthy older adults with known Alzheimer disease (AD) risk factors (family history, APOE epsilon4) from controls using a semantic memory task involving discrimination of famous from unfamiliar names.
  85. doi Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss
    P J Francis
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239 4197, USA
    J Med Genet 46:300-7. 2009
    ..This paper examines other AMD susceptibility genes to determine if these genotypes influenced disease progression and treatment response...
  86. doi Mitochondrial haplogroup H and Alzheimer's disease--is there a connection?
    Aleksandra Maruszak
    Department of Neurodegenerative Disorders, Polish Academy of Sciences Medical Research Center, 5 Pawinskiego Street, 02 106 Warsaw, Poland
    Neurobiol Aging 30:1749-55. 2009
    ..The frequency distribution of mtDNA haplogroups was non-randomly associated with APOE4 status (chi(2)=73.17, df=1, p<0.0001, OR=5.97, 95% CI 3.90-9...
  87. pmc Brain network local interconnectivity loss in aging APOE-4 allele carriers
    Jesse A Brown
    Center for Cognitive Neuroscience, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 108:20760-5. 2011
    Old age and possession of the APOE-4 allele are the two main risk factors for developing later onset Alzheimer's Disease (AD)...
  88. pmc Familial apolipoprotein E deficiency
    E J Schaefer
    J Clin Invest 78:1206-19. 1986
    ..Homozygotes had only trace amounts of plasma apoE, and accumulations of apoB-48 and apoA-IV in VLDL, IDL, and low density lipoproteins...
  89. ncbi Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholine
    Clare A Peters-Libeu
    Gladstone Institute of Cardiovascular Disease and Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    J Biol Chem 281:1073-9. 2006
    ..This interaction requires apoE to be associated with a lipoprotein particle...
  90. ncbi Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers
    Christian R A Mondadori
    Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
    Cereb Cortex 17:1934-47. 2007
    The apolipoprotein E (APOE) epsilon4 allele is the major genetic risk factor for Alzheimer's disease, but an APOE effect on memory performance and memory-related neurophysiology in young, healthy subjects is unknown...
  91. ncbi Apolipoprotein E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary heart disease in 12,491 ARIC study participants
    Kelly A Volcik
    Human Genetics Center, University of Texas Health Science Center, Houston, TX 77030, USA
    Am J Epidemiol 164:342-8. 2006
    ..b>Apolipoprotein E (ApoE) has been widely studied in regard to its role in lipid transport and metabolism, but the role that ..
  92. ncbi The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor
    Jose Ruiz
    Department of Surgery, University of Maryland School of Medicine, Rockville, MD 21201, USA
    J Lipid Res 46:1721-31. 2005
    b>Apolipoprotein E (apoE) associates with lipoproteins and mediates their interaction with members of the LDL receptor family. ApoE exists as three common isoforms that have important distinct functional and biological properties...
  93. pmc Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13
    Ralph Burkhardt
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10065, USA
    Arterioscler Thromb Vasc Biol 28:2078-84. 2008
    ..Background- Variation in LDL-cholesterol (LDL-C) among individuals is a complex genetic trait involving multiple genes and gene-environment interactions...
  94. pmc Association of glucocerebrosidase mutations with dementia with lewy bodies
    Lorraine N Clark
    Taub Institute for Research onAlzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
    Arch Neurol 66:578-83. 2009
    ..Mutations in the glucocerebrosidase (GBA) gene are associated with Lewy body (LB) disorders...
  95. pmc The role of apolipoprotein E in Alzheimer's disease
    Jungsu Kim
    Department of Neurology, Developmental Biology, Hope Center for Neurological Disorders, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 63:287-303. 2009
    The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD)...
  96. pmc APOE polymorphism is associated with lipid profile, but not with arterial stiffness in the general population
    Rafael O Alvim
    Heart Institute InCor, University of Sao Paulo Medical School, Brazil
    Lipids Health Dis 9:128. 2010
    ..The purpose of this study was to investigate the association between APOE genotypes, cardiovascular risk factors, and a non-invasive measure of arterial stiffness in the Brazilian population...
  97. pmc Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease
    W J Strittmatter
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
    Proc Natl Acad Sci U S A 91:11183-6. 1994
    The apolipoprotein E (apoE) type 4 allele (APOE4) is a susceptibility gene for late-onset familial and sporadic Alzheimer disease...
  98. pmc Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease
    Carlos Cruchaga
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Neurol 68:1013-9. 2011
    b>Apolipoprotein E (APOE) is the most statistically significant genetic risk factor for late-onset Alzheimer disease (LOAD)...
  99. pmc Genome-wide analysis of genetic loci associated with Alzheimer disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    JAMA 303:1832-40. 2010
    ..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)...
  100. ncbi Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis
    P M Sullivan
    Department of Pathology and Laboratory of Medicine, The University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
    J Biol Chem 272:17972-80. 1997
    ..We found, however, notable differences in the distribution of plasma lipoproteins and apolipoprotein E between the two groups: beta-migrating lipoproteins and plasma apoB100 levels are decreased in the 3/3 mice, ..
  101. pmc Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis
    Jungsu Kim
    Department of Neurology, Developmental Biology, Hope Center for Neurological Disorders, Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 31:18007-12. 2011
    The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer's disease (AD)...

Research Grants108 found, 100 shown here

  1. Preclinical Pharmacogenomics and Synaptic Biomarkers for Alzheimer's Disease
    Gregory M Cole; Fiscal Year: 2013
    ..In this proposal, we focus on ApoE4, the major genetic risk factor for AD...
  2. Next Generation Mendelian Genetics in Familial Alzheimer Disease
    Zoran Brkanac; Fiscal Year: 2013
    ..genome-wide association studies have not found strong evidence for the contribution of common variants besides the APOE gene...
  3. Analyses of AD relevant phenotypes in neural cells derived from human iPSCs
    Tracy L Young-Pearse; Fiscal Year: 2012
    ..of both a strong, dominantly inherited familial Alzheimer's disease (fAD) mutation and an allelic variant in APOE that increases risk for AD...
  4. Genomic Search for Susceptibility to Alzheimer Disease
    Alison M Goate; Fiscal Year: 2010
    ..Studies of late onset AD (LOAD) have implicated genotype at the apolipoprotein E (APOE) locus as a major risk factor that also acts via an Ass dependent mechanism...
  5. The Effects of APOE on Neuronal Networks
    SONYA DUMANIS; Fiscal Year: 2012
    ..If brain atrophy is observed in APOE4 TR mice, this would suggest that E4 carriers may have simplified anatomical connections, which contribute to ..
  6. APOE and Brain Injury in Premies
    James A Blackman; Fiscal Year: 2010
    ..Studies have examined the effects of Apolipoprotein E (APOE) genotype on outcomes after BI, primarily in adults...
  7. Identifying Alzheimer's disease genes using genomic and family data
    ELIZABETH MARCHANI BLUE; Fiscal Year: 2012
    ..a postdoctoral fellow, she has recently published evidence that several genes in addition to APP, PSEN1, PSEN2, and APOE influence Alzheimer's disease...
  8. Identifying Alzheimer's disease genes using genomic and family data
    ELIZABETH MARCHANI BLUE; Fiscal Year: 2013
    ..a postdoctoral fellow, she has recently published evidence that several genes in addition to APP, PSEN1, PSEN2, and APOE influence Alzheimer's disease...
  9. METABOLISM OF THE VLDL RECEPTOR AND APOE RECEPTOR 2
    JOACHIM J HERZ; Fiscal Year: 2013
    ..LDL) receptor gene family represents one class of such receptors that bind the lipid transport protein Apolipoprotein E. Three isoforms of ApoE exist in the human population, E2, E3 and E4...
  10. Functional Analysis of ACAT
    Ta Yuan Chang; Fiscal Year: 2013
    ..conduct structure-function analysis of ACAT1 in vitro, and to examine the role of macrophage ACAT1 in vivo in the Apoe-/- mouse model and the Ldlr-/- apoB48-deficient mouse model for atherosclerosis...
  11. The aging brain: Imaging genetics of brain structure and function
    Ira Driscoll; Fiscal Year: 2013
    ..The primary aims are to: (1) measure variation in five candidate genes (APOE, SORL1, BDNF, COMT, and KIBRA), all with known involvement in either dementia or cognitive impairment, and examine ..
  12. Macrostructural and Microstructural Imaging Biomarkers of Traumatic Brain Injury
    Pratik Mukherjee; Fiscal Year: 2012
    ..Specifically, we will examine whether ApoE genotype influences the degree of regional brain atrophy and microstructural white matter injury...
  13. Risk Evaluation and Education for Alzheimer's Disease (REVEAL IV)
    Robert C Green; Fiscal Year: 2012
    ..Our paradigm for these trials is disclosure of Apolipoprotein E (APOE) genotype as part of risk assessment for Alzheimer's disease (AD) to unaffected individuals...
  14. ApoE isoform-specific therapy for Alzheimer disease
    Guojun Bu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The [unreadable]4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) compared to the more common [unreadable]3 allele...
  15. Genetic Epidemiology of HAD Susceptibility Genes
    Sunil Ahuja; Fiscal Year: 2009
    ..Aim #3 will test the hypothesis that neuronal susceptibility to MP-mediated inflammatory damage is linked to APOE genotypes...
  16. Genetics of Telomere Dynamics in Okinawans
    Donald Craig Willcox; Fiscal Year: 2013
    ..Until recently, only variation within the APOE gene had been firmly associated with human lifespan and healthspan...
  17. Epistasis in Steroidogenic Genes in the Prediction of Alzheimer's Disease
    CRAIG STEPHEN ATWOOD; Fiscal Year: 2013
    ..Importantly, APOE ?4, the major risk factor for AD, and ABCA7, recently associated with AD from GWAS, alter the neuronal transport of ..
  18. Longitudinal Study of Lipids and APOE in the Development of AD and AD Pathology
    Michelle M Mielke; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The E4 allele of the Apolipoprotein E (ApoE) gene is the strongest genetic risk factor for the onset of sporadic Alzheimer's disease (AD) identified to date...
  19. Outcomes and Predictors in Mild Cognitive Impairment
    Mary Ganguli; Fiscal Year: 2012
    ..Health history and neurological exam, blood pressure, total and HDL cholesterol, and APOE genotype are already being measured on all participants...
  20. Building a Better AMD Mouse
    Caroline J Zeiss; Fiscal Year: 2010
    ..In Aim 1, we will breed mice lacking one or more genes conferring AMD risk in humans (CFH) or mice (ApoE, Ccr2) and expose these to normal or high fat high cholesterol diets...
  21. ApoE and Cholesterol Effects on Amyloid-beta in Synaptic Terminals in AD
    Karen H Gylys; Fiscal Year: 2012
    ..in lipid raft domains enhances processing of APP to AB;therefore manipulation of terminal cholesterol via ApoE genotype and drug treatment will alter the accumulation of AB and related lipids and peptides, and will affect ..
  22. Low-Burden Tools for Improving Prediction and Diagnosis of Cognitive Impairment.
    VALERIE FRANCES REYNA; Fiscal Year: 2010
    ..g., the ApoE genotype), behavioral markers of impairment (e.g., neuropsychological tests), and clinical diagnoses of impairment...
  23. ApoE4 Structure Correctors as a Therapeutic Approach for Alzheimers Disease
    Robert W Mahley; Fiscal Year: 2013
    ..b>ApoE4 is the major genetic risk factor for AD, and apoE4 carriers account for 65-80% of all cases of AD...
  24. Myelin integrity and Connectivity in Subjects at Risk for Alzheimer Disease
    JESSE AARON BROWN; Fiscal Year: 2012
    ..develop earlier in subjects defined as "at risk", based on a family history of the disease and/or carriage of the APOE e4 allele...
  25. ALZHEIMERS DISEASE RESEARCH CENTER
    John Morris; Fiscal Year: 2013
    ..Changing tau protein levels and tau protein isoforms in mouse models of dementia;(Timothy Miller) 3. APOE metabolism in AD and controls;(Randall Bateman).
  26. National Cell Respository for Alzheimer's Disease (NCRAD) (U24)
    Tatiana M Foroud; Fiscal Year: 2013
    ..also widely distributes samples both to investigators for their own analyses as well as to central cores, where APOE genotyping, genomewide SNP arrays, and now whole genome and whole exome sequencing studies are performed...
  27. Genomic Convergence in Alzheimer Disease
    Margaret A Pericak-Vance; Fiscal Year: 2012
    ..Our group has successfully used this paradigm in both the identification of the APOE risk effect and more recently the glutathione S-transferase Omega-1 (GSTO1) age at onset (AAO) effect in AD...
  28. MRI Biomarker Discovery for Preclinical Alzheimers Disease with Geometry Methods
    Yalin Wang; Fiscal Year: 2013
    ..We will develop and apply novel geometric algorithms to brain MRIs obtained from the well-characterized Arizona APOE cohort of presymptomatic individuals and the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset...
  29. Destablization of LRP family receptors by Alzheimer-related presenilin mutations
    Steven W Barger; Fiscal Year: 2013
    ..LRP) family is of interest in Alzheimer disease (AD) research because it includes several receptors for apolipoprotein E (ApoE), and polymorphisms in the gene for the latter (APOE) create the most demographically significant ..
  30. Early Life Conditions, Survival, and Health: A Pedigree-Based Population Study
    Ken R Smith; Fiscal Year: 2013
    ..We also test if there is effect modification of APOE alleles on the association between ELCS &later-life biomarkers.
  31. ApoE and ApoER2 mediated regulation of APP metabolism
    Preeti Khandelwal; Fiscal Year: 2011
    ..ApoE (Apolipoprotein E), a cholesterol carrier in the brain is the only known and most widely accepted genetic risk factor for late ..
  32. Human ApoE4 and Foam Cell Formation
    EMMANUEL UGOCHUKWU OKORO; Fiscal Year: 2011
    ..the mechanism(s) leading to excess cholesterol accumulation in macrophages treated with apolipoprotein E4 (ApoE4)-enriched lipoproteins, and to elucidate the role of unfolded protein response (UPR) in this process...
  33. Epigenomic Characterization of Alzheimer's Disease Neurons from iPSCs
    Li Huei Tsai; Fiscal Year: 2012
    ..of HDAC2 mRNA and protein in these iPSC-derived neurons, and will PCR-sequence each sporadic AD line for the APOE genotype...
  34. Underlying Mechanisms of ApoE in HCV Infection and Assembly
    GUANGXIANG GEORGE LUO; Fiscal Year: 2013
    ..by applicant): The overall goal of this application is to determine the importance of the cellular protein apolipoprotein E (apoE) in hepatitis C virus (HCV) infection and production in vivo and to define the underlying molecular ..
  35. Selenium, other risk factors and cognitive decline in rural elderly Chinese
    Sujuan Gao; Fiscal Year: 2013
    ..In addition, there is an intrigue finding that apolipoprotein E (APOE) 54 allele carriers had significantly lower selenium levels measured in nail samples even though the ..
  36. PTSD, Sleep-Disordered Breathing and APOE Genotype: Effects on Cognition
    Jerome A Yesavage; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): To examine whether sleep disordered breathing (SDB), Apolipoprotein 54 (APOE 54) status, increasing age and their interactions will predict rate of cognitive decline in veterans who have PTSD, a ..
  37. Domains of Inflammation and Risk of Dementia
    Annette L Fitzpatrick; Fiscal Year: 2013
    ..that were found in GEMS provides adequate power for these analyses overall and within subgroups such as gender and ApoE genotype...
  38. Association of TFPI with antemortem dementia and postmortem micro brain infarcts
    SUSAN ANTONE MARONEY; Fiscal Year: 2013
    ..In Aim3 we will correlate the TFPI plasma concentrations and activity with lipoprotein levels and ApoE genotype of the cohort which have been previously determined...
  39. ACTIVE Phase III: IU Field Site
    Frederick W Unverzagt; Fiscal Year: 2010
    ..response to training, including such factors as low cognitive function, cardiovascular status, engagement, and ApoE genotype...
  40. ACTIVE Phase III: UAB Field Site
    Karlene K Ball; Fiscal Year: 2010
    ..response to training, including such factors as low cognitive function, cardiovascular status, engagement, and ApoE genotype...
  41. ACTIVE Phase III: HRC Field Site
    John N Morris; Fiscal Year: 2010
    ..response to training, including such factors as low cognitive function, cardiovascular status, engagement, and ApoE genotype...
  42. Influence of apoE on LRP1 function and Beta-Amyloid Transport Across the BBB
    Fiona C Crawford; Fiscal Year: 2013
    ..One of the ligands with which LRP1 interacts is apolipoprotein E (apoE) and possession of the E4 allele represents the strongest genetic risk factor for AD...
  43. Lifespan Stressors and Alzheimer's Disease: The Cache County Study
    Maria C Norton; Fiscal Year: 2010
    ..adversity places those with later adversity at enhanced risk, 3) Examine Early-onset Major Depression (EOD) and APOE for moderating effects on the association between life stressors and cognitive outcomes...
  44. ACTIVE Phase III: PSU Field Site
    Sherry L Willis; Fiscal Year: 2010
    ..response to training, including such factors as low cognitive function, cardiovascular status, engagement, and ApoE genotype...
  45. ACTIVE Phase III: JHU Field Site
    George W Rebok; Fiscal Year: 2010
    ..response to training, including such factors as low cognitive function, cardiovascular status, engagement, and ApoE genotype...
  46. ACTIVE Phase III: UF/WSU Field Site
    Michael Marsiske; Fiscal Year: 2010
    ..response to training, including such factors as low cognitive function, cardiovascular status, engagement, and ApoE genotype...
  47. Small Molecule Screen for Apolipoprotein-E/Alzheimer's Disease
    MICHAEL PETER VITEK; Fiscal Year: 2012
    ..Behind age, the second largest risk factor for AD is APOE (apolipoprotein-E) genotype where APOE4 carriers are at significantly higher risk for AD than their non-APOE4 (mainly APOE3) counterparts...
  48. The Effect of Physical Activity on Cognition Relative to APOE Genotype
    Jennifer L Etnier; Fiscal Year: 2013
    ..baseline PA and subsequent cognitive performance is moderated by a susceptibility gene for AD (apolipoprotein, APOE) [10-13]...
  49. Amyloid Imaging, VMCI, and Analysis for ADNI
    Michael W Weiner; Fiscal Year: 2010
    ..This sequence is influenced by factors including age, APOE genotype, cerebrovascular disease, and other pathologies...
  50. Chronic Traumatic Encephalopathy: Clinical Presentation and Biomarkers
    Robert A Stern; Fiscal Year: 2013
    ..In addition, APOE genotype will be examined as a potential moderating variable, based on our neuropathological findings and other ..
  51. Role of Fibrinogen in Alzheimer's Disease
    Sidney Strickland; Fiscal Year: 2013
    ..In keeping with the known genetic interaction between AD and the ApoE genotype, we have also demonstrated that ApoE affects the interaction between fibrinogen and A[unreadable] and the ..
  52. Profiling Pathologically Normal ApoE Variants to Identify Pathways for AD
    Karen E Duff; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The project aims to explore why inheritance of the E4 variant of apolipoprotein E (ApoE4) is a significant risk factor for onset and progression of AD...
  53. The VETSA Longitudinal Twin Study of Cognition and Aging
    Michael J Lyons; Fiscal Year: 2012
    ..cognitive effort and performance (Aims 1, 2), and to examine major factors that mediate or moderate those changes: APOE [Aim 3];other biomedical risks [Aim 4];lifestyle/psychosocial factors [Aim 5])...
  54. The VETSA Longitudinal Twin Study of Cognition and Aging
    William S Kremen; Fiscal Year: 2012
    ..cognitive effort and performance (Aims 1, 2), and to examine major factors that mediate or moderate those changes: APOE [Aim 3];other biomedical risks [Aim 4];lifestyle/psychosocial factors [Aim 5])...
  55. Genetic Factors that Impact the Risk of Alzheimer's Disease
    Allen D Roses; Fiscal Year: 2010
    ..The general relationship between APOE genotype and the age of onset for AD is well-documented since 1993...
  56. KEEPS Cognitive and Affective Study
    Sanjay Asthana; Fiscal Year: 2013
    ..between estrogen-related changes in proposed markers of inflammation, blood hypercoagulability, and tests of cognition and mood, and 5) to determine if ApoE genotype will influence cognitive responsitivity to HT.
  57. The role of apoE and APOE genotype in amyloid-beta clearance after TBI
    Mark P Burns; Fiscal Year: 2013
    ..The APOE gene encodes for the apolipoprotein E (apoE) protein, which was recently shown to facilitate the enzymatic degradation of A[unreadable]...
  58. Neuromuscular Fatigue: Age and Sex Differences
    Sandra K Hunter; Fiscal Year: 2011
    ..Importantly, Apolipoprotein-E e4 (APOE e4) allele inheritance conveys greater risk with increasing age of cognitive decline, and recently was associated ..
  59. A Study of APOE and TOMM40 in a large Cerebral Palsy Registry
    James A Blackman; Fiscal Year: 2010
    ..b>Apolipoprotein E (APOE) is important in the brain for neuronal maintenance and repair after injury...
  60. Progression of Dementia: A Population Study
    JOANN T contact TSCHANZ; Fiscal Year: 2010
    ..occur in clusters, c) vascular factors, their treatments, and the care environment modify progression, and d) the APOE e4 allele modifies the effects of other factors...
  61. ACTIVE Coordinating Center
    Sharon L Tennstedt; Fiscal Year: 2010
    ..response to training, including such factors as low cognitive function, cardiovascular status, engagement, and ApoE genotype...
  62. TWO PRECLINICAL LATENT SCORES TO PREDICT OCCURRENCE OF DAT
    Chengjie Xiong; Fiscal Year: 2013
    ..g., education and cognitive activities), ApoE genotype, preclinical measures of biomarkers including cerebrospinal fluid (CSF) molecular biomarkers, MRI brain ..
  63. Neuroanatomical Substrates of Aging & Cognitive Decline
    Gene E Alexander; Fiscal Year: 2010
    ..Among these factors include differences in blood pressure, aerobic fitness, and the presence of the apolipoprotein E (APOE) s4 allele, a common susceptibility gene for Alzheimer's disease...
  64. The Anterior Cingulate Cortex and Cognitive Aging
    Jose V Pardo; Fiscal Year: 2013
    ..2) ACC metabolism will decline with aging and APOE4 genotype and will further anticipate conversion to MCI...
  65. APOEomic: Searching for APOE interacting risk factors using omics data
    Amanda J Myers; Fiscal Year: 2013
    ..Each GWAS that has been published to date has mapped the Apolipoprotein E (APOE) locus as the strongest LOAD risk signal within the human genome...
  66. Biological Underpinnings and Cognitive Expression of Brain Aging
    Po Lu; Fiscal Year: 2012
    ..Apolipoprotein E4 (ApoE4) genotype increases the likelihood of developing AD and decreases age of onset...
  67. The VETSA Longitudinal MRI Twin Study of Aging
    William S Kremen; Fiscal Year: 2013
    ..determine genetic and environmental influences on brain structure changes over time;3) examine the relationship of APOE genotype to changes in brain structure over time;4) elucidate biomedical and other risk factors related to changes ..
  68. Epigenomics of Alzheimer's Disease
    Benjamin Tycko; Fiscal Year: 2013
    ..emphasis in AD research has been on genetic studies, which have uncovered the fundamental involvement of the APP, APOE and PS1 genes...
  69. Ozone, apoE4, aging, and Alzheimer's disease
    Rui Ming Liu; Fiscal Year: 2013
    ..b>Apolipoprotein E (apoE) is a major lipid transporter that exists in three isoforms (E2, E3, and E4) in human, coded by 3 ..
  70. Cognition In Older Breast Cancer Survivors: Treatment Exposure, APOE, &Smoking
    Arti Hurria; Fiscal Year: 2013
    ..pursue the following specific aims while controlling for comorbidity and frailty: Aim 1: Examine the association of APOE status, smoking history, and therapeutic exposures on the cognitive performance among older breast cancer survivors ..
  71. LXR and human ApoE isoform effects on AD phenotype: in vitro and in vivo models
    Radosveta P Koldamova; Fiscal Year: 2013
    ..Compared with APOE3 carriers, higher incidence of AD and increased amyloid deposition in APOE4 carriers might be a result of lower ApoE protein levels observed in these patients...
  72. CITALOPRAM DECREASES CSF AB: A RANDOMIZED DOSE FINDING TRIAL
    Yvette I Sheline; Fiscal Year: 2013
    ..Prior to randomization they will be stratified by APOE4 status...
  73. Biomarker Expression and Regulatory Haplotypes in Alzheimer's Disease
    LYNN MATTHEWS BEKRIS; Fiscal Year: 2013
    ..The apolipoprotein (APOE) [unreadable]4 allele and age are currently the only factors strongly associated with late onset AD...
  74. Mild Cognitive Impairment: A Prospective Community Study
    Mary Ganguli; Fiscal Year: 2013
    ..In 2008, the cohort completed recruitment of 2036 individuals aged 65+, and the majority of them have had APOE genotyping. We conduct annual followup assessments in overlapping 2-year cycles...
  75. Clinical, Imaging, and Pathological Studies in the Oldest Old: The 90+ Study
    Claudia H Kawas; Fiscal Year: 2013
    ..In addition to traditional risk factors, such as APOE, exercise, and physical performance, we will study novel factors (fluctuations in blood pressure and O2 saturation)...
  76. Multimodal MRI Biomarker of Mild Cognitive Impairment in Breast Cancer
    JEFFREY SCOTT WEFEL; Fiscal Year: 2013
    ..function, mood and behavior with advanced, non-invasive multimodal magnetic resonance imaging techniques and APOE genotyping...
  77. Health behaviors over the adult lifecourse and cognitive aging
    Archana Singh-Manoux; Fiscal Year: 2013
    ..modifiers of the association between health behaviors and cognitive aging: socioeconomic status (SES) and the apolipoprotein E (APOE) e4 allele...
  78. Co-Regulation of ApoE and Abeta By Synaptic Activity
    JASON ULRICH; Fiscal Year: 2013
    ..genetic determinant for the development of the most common form of AD, late onset AD, is possession of the apolipoprotein E 4 allele (APOE4)...
  79. Role of the TOMM40 poly-T variant in the pathogenesis of Alzheimer's disease
    Allen D Roses; Fiscal Year: 2013
    ..For APOE e3/4 patients who develop AD, those with long poly-T repeats linked to APOE e3 developed AD on average 7 years ..
  80. Amyloid Beta-Protein: ApoE and Cholesterol Homeostasis
    WELLINGTON WOOD; Fiscal Year: 2009
    ..Primary astrocytes from mice expressing human apoE2, apoE3, apoE4, apoE-null mice, caveolin-l-null mice and human astrocytes will be used...
  81. Neurorestorative Strategy for Diabetic Peripheral Neuropathy
    Feng Qiao Li; Fiscal Year: 2013
    ..Cognosci has innovatively created and characterized a series of peptides derived from human apolipoprotein E (apoE), which we designate as "COG" compounds, from which we have identified a lead compound COG112 for ..
  82. Lipid genotypes, phenotypes, and colorectal adenomas: Elucidating mechanisms
    Polly A Newcomb; Fiscal Year: 2013
    ..genetic loci known to influence lipid levels and the risk of colorectal neoplasia, including PCSK9, ABCG8, and APOE, but these studies have been limited to only a few candidate genes...
  83. Tobacco Products and Atherosclerotic Disease
    Sanjay Srivastava; Fiscal Year: 2013
    ..To accomplish this goal we will examine tobacco-induced injury in apoE-null mice and apoE-null rats...
  84. Periodontal Pathogens-induced Atherosclerosis in ApoE-/- and Integrin Beta6-/- mi
    IRINA MARIE VELSKO; Fiscal Year: 2013
    ..The data from these studies will strengthen the evidence for a direct association between PD and ASVD, and will emphasize the importance of maintaining oral health for overall systemic health. ..
  85. Functional significance of amyloid dynamics and deposition in the AD brain
    Gary E Landreth; Fiscal Year: 2013
    ..disease is associated with impaired clearance of Abeta from the brain, a process normally facilitated by apolipoprotein E (ApoE)...
  86. A Novel Role of Macrophage TSP1-CD47 Signaling in Atherosclerosis
    Gabor Csanyi; Fiscal Year: 2013
    ..Unique CD47 null [unreadable]ApoE null bone marrow chimeras will be created to investigate the contribution of macrophage CD47 to plaque rupture and ..
  87. Shear stress, endothelial miRNAs, and AV calcification
    Ajit P Yoganathan; Fiscal Year: 2013
    ..AV disease will be modeled in vivo using ApoE-/- mice fed a Western diet...
  88. AMPK as a redox sensor and modulator
    Ming Hui Zou; Fiscal Year: 2013
    ..abnormal expression and activation of matrix metalloproteinase 2 (MMP2), and an increased incidence of AAA in ApoE knockout (ApoE-/-) mice...
  89. Role of RTN-4 in Atherosclerosis
    Jun Yu; Fiscal Year: 2013
    ..Our exciting preliminary data demonstrate that Nogo-/- mice on an ApoE knockout background (ApoE-/-Nogo-/-) develop larger and more advanced atherosclerotic lesions with increased ..
  90. Genetic link between type 2 diabetes and atherosclerosis
    Weibin Shi; Fiscal Year: 2013
    ..is whether there are genetic connections between common forms of atherosclerosis and T2DM? We have found that apolipoprotein E-deficient (Apoe-/-) mice on the C57BL/6 (B6) background develop T2DM when fed a Western diet...
  91. P. gingivalis Mediated Evasion Strategies
    Caroline A Genco; Fiscal Year: 2013
    ..gingivalis-induced chronic inflammation at systemic sites in an ApoE-/- murine model...
  92. Cognitive Function in Snoring Children
    David Gozal; Fiscal Year: 2013
    ..Specifically, we will examine IL-6, TNF-1, and ApoE polymorphisms, as well as plasma levels of IL-6, TNF-1 , soluble CD40 ligand, and high sensitivity CRP, and ..
  93. BMP-7 induced Macrophage Polarization in Atherosclerosis
    Dinender Kumar Singla; Fiscal Year: 2013
    ..In vivo preliminary data suggests that intravenous injection of BMP-7 in ApoE KO mice experiencing a partial ligated coronary artery (PLCA) have increased M2 polarized macrophages, increased ..
  94. Circadian regulation of lipid metabolism
    M Mahmood Hussain; Fiscal Year: 2013
    ..Bmal1-/- /Ldlr-/- and Bmal1-/-/Apoe-/- mice on C57BL/6J background will be fed ad libitum chow or western diet and development of atherosclerosis will ..
  95. Therapeutic for Intracerebral Hemorrhage
    Dale Christensen; Fiscal Year: 2009
    ..modifying the CNS response to injury, and in the case of ICH, a pharmacogenomic effect has been demonstrated where APOE4 carriers suffer worse outcome relative to their APOE3 counterparts...
  96. Alzheimer's Prevention Initiative APOE4 Trial
    Pierre N Tariot; Fiscal Year: 2013
    ..amyloid-[unreadable] (A[unreadable]) modifying treatment in 650 cognitively unimpaired 60-75 year-old apolipoprotein E (APOE) [unreadable]4 homozygotes (HMs) using the best established cognitive, brain imaging and cerebrospinal ..
  97. Ultrasound-triggered drug delivery with acoustically active red blood cells
    Alexander L Klibanov; Fiscal Year: 2013
    ..AARBC targeting to VCAM-1 will be assessed by contrast ultrasound imaging in ApoE -/- mice on high-cholesterol diet, followed by ultrasound-triggered image-guided AARBC release of contents, and a ..
  98. Targeting the apoE/ABeta Interaction as a Novel AD Therapy
    MARTIN JOSEPH SADOWSKI; Fiscal Year: 2013
    ..provided by applicant): Our main hypothesis is that a therapeutic agent blocking the interaction between apolipoprotein E and B-amyloid will be effective in reducing and preventing 6-amyloid ( AB ) related pathology of Alzheimer&..
  99. Role of the Inflammatory Cytokine Oncostatin-M in Promoting Atherosclerosis
    Errol Wijelath; Fiscal Year: 2013
    ..Aim 1: Test the hypothesis that the transcriptional factor STAT-1 promotes the development of atherosclerosis in ApoE-deficient mice...
  100. Endocrine disruptor mediated activation of PXR causes dyslipidemia
    Changcheng Zhou; Fiscal Year: 2013
    ..activation induces hyperlipidemia in wild-type mice and increases atherosclerosis in atherosclerosis-prone apolipoprotein E deficient (ApoE-/-) mice...
  101. Activators of the Pyrophosphatase Activity of Alkaline Phosphatase
    Jose Luis Millan; Fiscal Year: 2007
    ..Transgenic mice were generated by expressing human TNAP cDNA under control of the Apolipoprotein E promoter, which drives expression of TNAP primarily in the post- natal liver...