apoA-I

Summary

Gene Symbol: apoA-I
Description: apolipoprotein A1
Alias: apo(a), apolipoprotein A-I, apo-AI
Species: human

Top Publications

  1. pmc Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high density lipoprotein
    Junji Watanabe
    Atherosclerosis Research Unit, Department of Medicine Cardiology, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:18292-301. 2009
  2. pmc ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation
    Ashley M Vaughan
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 50:285-92. 2009
  3. doi Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity
    Elizabeth Suchi Chen
    Disciplina de Genetica, Departamento de Morfologia e Genética, Escola Paulista de Medicina Universidade Federal de Sao Paulo, Rua Botucatu, 740, Edifício Leitão da Cunha 1 andar, Sao Paulo, SP, CEP 04023 900, Brazil
    Clin Exp Med 9:319-25. 2009
  4. pmc Relationship of apolipoproteins A-1 and B, and lipoprotein(a) to cardiovascular outcomes: the AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglyceride and Impact on Global Health Outcomes)
    John J Albers
    Northwest Lipid Metabolism and Diabetes Research Laboratories, Department of Medicine, University of Washington, Seattle, Washington
    J Am Coll Cardiol 62:1575-9. 2013
  5. ncbi The relation between apolipoprotein A-I and dementia: the Honolulu-Asia aging study
    Jane S Saczynski
    Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892, USA
    Am J Epidemiol 165:985-92. 2007
  6. doi Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese
    Zhi Kai Liu
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China
    Atherosclerosis 208:427-32. 2010
  7. pmc Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers
    Mary G Sorci-Thomas
    Department of Pathology, Section on Lipid Sciences, Wake Forest Baptist Medical Center, Winston Salem, NC 27157, USA
    J Lipid Res 53:1890-909. 2012
  8. ncbi Electron paramagnetic resonance spectroscopy of site-directed spin labels reveals the structural heterogeneity in the N-terminal domain of apoA-I in solution
    Jens O Lagerstedt
    Department of Biochemistry, University of California, Davis, California 95616, USA
    J Biol Chem 282:9143-9. 2007
  9. pmc Interaction between the N- and C-terminal domains modulates the stability and lipid binding of apolipoprotein A-I
    Mao Koyama
    Department of Biophysical Chemistry, Kobe Pharmaceutical University, 4 19 1 Motoyamakitamachi, Higashinada ku, Kobe 658 8558, Japan
    Biochemistry 48:2529-37. 2009
  10. ncbi Amyloid contained in the knee joint meniscus is formed from apolipoprotein A-I
    Alan Solomon
    University of Tennessee Center for Health Sciences, College of Medicine, Knoxville, USA
    Arthritis Rheum 54:3545-50. 2006

Research Grants

  1. ANTONIO PAUL; Fiscal Year: 2014
  2. Hong Wang; Fiscal Year: 2016
  3. Unraveling the Genetic Architecture of Very High HDL cholesterol though Transcrip
    Michael Miller; Fiscal Year: 2010
  4. Regulation of Macrophage Reverse Cholesterol Transport by BRCA1
    Ira G Schulman; Fiscal Year: 2013
  5. Role of H3K4 methylation in transcriptional activation by FoxA
    Janice M Ascano; Fiscal Year: 2010
  6. Alice S Chen-Plotkin; Fiscal Year: 2016
  7. HYPERAPOLIPOPROTEIN B AND CORONARY ARTERY DISEASE
    Peter Kwiterovich; Fiscal Year: 1991
  8. MOLECULAR ASPECTS OF AMYLOIDOSIS
    WARREN LIAO; Fiscal Year: 1999
  9. Yury Miller; Fiscal Year: 2014
  10. Safe and Efficacious Non-viral Vectors for Gene Therapy
    Leaf Huang; Fiscal Year: 2007

Patents

  1. Expression of human proapolipoprotein A-1

Detail Information

Publications305 found, 100 shown here

  1. pmc Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high density lipoprotein
    Junji Watanabe
    Atherosclerosis Research Unit, Department of Medicine Cardiology, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:18292-301. 2009
    ..Our data strongly suggest that HDL can become proinflammatory via the Hb x Hp pathway in mice and humans, and dissociation of Hb x Hp x Hx complexes from apoA-1-containing particles of HDL may be a novel target for the treatment of CHD...
  2. pmc ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation
    Ashley M Vaughan
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 50:285-92. 2009
    ....
  3. doi Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity
    Elizabeth Suchi Chen
    Disciplina de Genetica, Departamento de Morfologia e Genética, Escola Paulista de Medicina Universidade Federal de Sao Paulo, Rua Botucatu, 740, Edifício Leitão da Cunha 1 andar, Sao Paulo, SP, CEP 04023 900, Brazil
    Clin Exp Med 9:319-25. 2009
    ..025). APOA1 polymorphisms analysis may be a useful tool to identify risk factors for subjects and families and clarify the physiopathological role of these polymorphisms in age-related diseases, such as hypertension and obesity...
  4. pmc Relationship of apolipoproteins A-1 and B, and lipoprotein(a) to cardiovascular outcomes: the AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglyceride and Impact on Global Health Outcomes)
    John J Albers
    Northwest Lipid Metabolism and Diabetes Research Laboratories, Department of Medicine, University of Washington, Seattle, Washington
    J Am Coll Cardiol 62:1575-9. 2013
    ....
  5. ncbi The relation between apolipoprotein A-I and dementia: the Honolulu-Asia aging study
    Jane S Saczynski
    Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892, USA
    Am J Epidemiol 165:985-92. 2007
    ..These results raise the possibility that different lipoprotein components of cholesterol may be differentially associated with dementia...
  6. doi Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese
    Zhi Kai Liu
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China
    Atherosclerosis 208:427-32. 2010
    ..We examined these associations with FCH in Hong Kong Chinese...
  7. pmc Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers
    Mary G Sorci-Thomas
    Department of Pathology, Section on Lipid Sciences, Wake Forest Baptist Medical Center, Winston Salem, NC 27157, USA
    J Lipid Res 53:1890-909. 2012
    ..Overall, these new data offer fresh insights into the biogenesis and structural constraints involved in forming nascent HDL from ABCA1...
  8. ncbi Electron paramagnetic resonance spectroscopy of site-directed spin labels reveals the structural heterogeneity in the N-terminal domain of apoA-I in solution
    Jens O Lagerstedt
    Department of Biochemistry, University of California, Davis, California 95616, USA
    J Biol Chem 282:9143-9. 2007
    ..Based on intermolecular dipolar coupling at positions 26, 44, and 64, these secondary structural elements were arranged into a tertiary fold to generate a structural model for lipid-free apoA-I in solution...
  9. pmc Interaction between the N- and C-terminal domains modulates the stability and lipid binding of apolipoprotein A-I
    Mao Koyama
    Department of Biophysical Chemistry, Kobe Pharmaceutical University, 4 19 1 Motoyamakitamachi, Higashinada ku, Kobe 658 8558, Japan
    Biochemistry 48:2529-37. 2009
    ..Taken together, these results suggest that interaction between the N- and C-terminal tertiary structure domains in apoA-I modulates the stability and lipid-binding properties of the N-terminal helix bundle...
  10. ncbi Amyloid contained in the knee joint meniscus is formed from apolipoprotein A-I
    Alan Solomon
    University of Tennessee Center for Health Sciences, College of Medicine, Knoxville, USA
    Arthritis Rheum 54:3545-50. 2006
    ..To determine the chemical nature of amyloid deposits found in knee joint menisci...
  11. ncbi ApoB C7623T polymorphism predicts risk for steroid-induced osteonecrosis of the femoral head after renal transplantation
    Tetsurou Hirata
    Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii chou, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
    J Orthop Sci 12:199-206. 2007
    ....
  12. ncbi Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1
    Tatyana G Vishnyakova
    NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:22771-80. 2003
    ..In summary, Cla-1 was found to bind and internalize monomerized and HDL-associated LPS, indicating that Cla-1 may play important role in septic shock by affecting LPS cellular uptake and clearance...
  13. ncbi Identification of liver receptor homolog-1 as a novel regulator of apolipoprotein AI gene transcription
    Philippe Delerive
    GlaxoSmithKline, Cardiovascular and Urogenital Center of Excellence for Drug Discovery, 91951 Les Ulis, France
    Mol Endocrinol 18:2378-87. 2004
    ..Chromatin immunoprecipitation experiments revealed that LRH-1 binds to the human APO AI promoter in vivo...
  14. ncbi A prospective study of the APOA1 XmnI and APOC3 SstI polymorphisms in the APOA1/C3/A4 gene cluster and risk of incident myocardial infarction in men
    Simin Liu
    Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Atherosclerosis 177:119-26. 2004
    ..However, whether genetic variations in the APOA1/C3/A4 gene cluster are associated with the risk of myocardial infarction (MI) remains uncertain and prospective data are sparse...
  15. doi Increased methionine sulfoxide content of apoA-I in type 1 diabetes
    Jonathan W C Brock
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, USA
    J Lipid Res 49:847-55. 2008
    ..Using the methods developed here, future studies can address the relationship between Met(O) in apoA-I and the risk, development, or progression of the vascular complications of diabetes...
  16. pmc Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1
    Jian Zhu
    Pfizer Global Research and Development, Department of Cardiovascular and Metabolic Diseases, Groton, CT 06340, USA
    J Lipid Res 50:1330-9. 2009
    ....
  17. ncbi Association of polymorphisms in apolipoprotein A1 and apolipoprotein B genes with lipid profile in Tamilian population
    N Padmaja
    Pharmacogenomics Laboratory, Department of Pharmacology, Jawaharlal Institute of Post Graduate Medical Education and Research, Pondicherry, India
    Indian Heart J 61:51-4. 2009
    ..For the first time genotype distribution of ApoAI and ApoB polymorphisms and their effect on lipid profile was established in Tamilians. Only -75G/A polymorphism of ApoAI was significantly associated with HDL7ndash;C levels...
  18. pmc Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol export
    Baohai Shao
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 51:1849-58. 2010
    ..Therefore, oxidation of apoA-I in the artery wall by MPO-generated chlorinating intermediates may contribute to atherogenesis by impairing cholesterol efflux from macrophages...
  19. pmc Identification of de novo synthesized and relatively older proteins: accelerated oxidative damage to de novo synthesized apolipoprotein A-1 in type 1 diabetes
    Abdul Jaleel
    Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes 59:2366-74. 2010
    ....
  20. doi Thermodynamics of protein self-association and unfolding. The case of apolipoprotein A-I
    F Zehender
    Division of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Biochemistry 51:1269-80. 2012
    ..0 ± 0.5 kJ mol(−1) K(−1) upon unfolding corresponding to a loss of 80−85 helical segments, which was confirmed by circular dichroism spectroscopy. Unfolding was highly cooperative with a nucleation parameter σ of 4.4 × 10(−5)...
  21. pmc Caveolin-1 reduces HIV-1 infectivity by restoration of HIV Nef mediated impairment of cholesterol efflux by apoA-I
    Shanshan Lin
    Department of Infectious Disease and Pathology, University of Florida, Gainesville, Florida, 32611, USA
    Retrovirology 9:85. 2012
    ..We investigated the effect of caveolin-1 (Cav-1) on the cholesterol efflux by apoA-I in HIV infected primary and THP-1 cell-differentiated macrophages as well as astrocyte derived glioblastoma U87 cells...
  22. doi Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl)
    Katrina A Hadfield
    The Heart Research Institute, 7 Eliza St, Newtown, NSW 2042, Australia
    Biochem J 449:531-42. 2013
    ..The ability of HOSCN to impair apoA-I-mediated cholesterol efflux may contribute to the development of atherosclerosis, particularly in smokers who have high plasma levels of SCN- (thiocyanate)...
  23. pmc Association of apolipoprotein A1 -75 G/A polymorphism with susceptibility to the development of acute lung injury after cardiopulmonary bypass surgery
    Jie Tu
    Institute of Cardiovascular Diseases, the First Affiliated Hospital of Guangxi, Medical University, 6 Shuangyong Road, Nanning, Guangxi 530021, China
    Lipids Health Dis 12:172. 2013
    ..The objective of this study was to investigate the potential association between APOA1 -75 G/A polymorphism and the development of ALI after cardiopulmonary bypass (CPB) surgery...
  24. pmc Evidence for the presence of lipid-free monomolecular apolipoprotein A-1 in plasma
    Osamu Miyazaki
    Tsukuba Research Institute, Research and Development Division, Sekisui Medical Co, Ltd, Ibaraki 301 0852, Japan
    J Lipid Res 55:214-25. 2014
    ..These results suggest that plasma preβ1-HDL is lipid-free monomolecular apoA-1. ..
  25. ncbi Variant apolipoprotein AI as a major constituent of a human hereditary amyloid
    W C Nichols
    Department of Medical Genetics, Indiana University School of Medicine, Indianapolis
    Biochem Biophys Res Commun 156:762-8. 1988
    ..This is the first report of an apolipoprotein as a major amyloid constituent in a form of autosomal dominant hereditary amyloidosis in humans...
  26. pmc Exchange of apolipoprotein A-I between lipid-associated and lipid-free states: a potential target for oxidative generation of dysfunctional high density lipoproteins
    Giorgio Cavigiolio
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    J Biol Chem 285:18847-57. 2010
    ..This impairment of apoA-I exchange reaction may be a trait of dysfunctional HDL contributing to reduced ATP-binding cassette A1-mediated cholesterol efflux and atherosclerosis...
  27. pmc Human apolipoprotein A-I-derived amyloid: its association with atherosclerosis
    Nahuel A Ramella
    Instituto de Investigaciones Bioquímicas La Plata INIBIOLP, CCT CONICET, La Plata, Argentina
    PLoS ONE 6:e22532. 2011
    ..We conclude that, even though apoA-I is not inherently amyloidogenic, it may produce non hereditary amyloidosis as a consequence of the pro-inflammatory microenvironment associated to atherogenesis...
  28. pmc Apolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosis
    A K Soutar
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    Proc Natl Acad Sci U S A 89:7389-93. 1992
    ..Discovery of this mutation and the detailed characterization of the apoAI fragments that form the amyloid fibrils open additional avenues for investigation of amyloidogenesis...
  29. ncbi Structural analysis of human apolipoprotein A-I variants. Amino acid substitutions are nonrandomly distributed throughout the apolipoprotein A-I primary structure
    A von Eckardstein
    Institut für Arterioskleroseforschung, Universitat Munster, Federal Republic of Germany
    J Biol Chem 265:8610-7. 1990
    ..These regions may therefore represent areas of less structural constraint for the function of apoA-I...
  30. pmc Apolipoprotein A-I variants. Naturally occurring substitutions of proline residues affect plasma concentration of apolipoprotein A-I
    A von Eckardstein
    Institut für Arterioskleroseforschung, Universitat Munster, Federal Republic of Germany
    J Clin Invest 84:1722-30. 1989
    ..This suggests that the interspecies conserved proline residue in position 3 of mature apo A-I is functionally important for the regular enzymatic conversion of proapo A-I to mature apo A-I...
  31. pmc Hereditary hepatic and systemic amyloidosis caused by a new deletion/insertion mutation in the apolipoprotein AI gene
    D R Booth
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    J Clin Invest 97:2714-21. 1996
    ....
  32. ncbi A novel apolipoprotein A-1 variant, Arg173Pro, associated with cardiac and cutaneous amyloidosis
    K Hamidi Asl
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Biochem Biophys Res Commun 257:584-8. 1999
    ..This suggests that altered metabolism caused by the mutation may be a significant factor in apolipoprotein A-1 fibrillogenesis...
  33. ncbi NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24
    Michael Hunter
    Laboratory for Molecular Genetics, Western Australian Institute for Medical Research and Centre for Medical Research, The University of Western Australia, Nedlands 6009, Australia
    Biochem Biophys Res Commun 332:982-92. 2005
    ....
  34. ncbi Effects of the core lipid on the energetics of binding of ApoA-I to model lipoprotein particles of different sizes
    Masafumi Tanaka
    The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    Biochemistry 44:10689-95. 2005
    ....
  35. doi The central type Y amphipathic alpha-helices of apolipoprotein AI are involved in the mobilization of intracellular cholesterol depots
    Marina C Gonzalez
    Instituto de Investigaciones Bioquímicas de La Plata INIBIOLP, CONICET UNLP, Facultad de Ciencias Medicas, calles 60 y 120, La Plata 1900, Buenos Aires, Argentina
    Arch Biochem Biophys 473:34-41. 2008
    ..We conclude that the central domain of apoAI is involved in cholesterol cell traffic and solubilization, and that a Y-type charge distribution in polar face may be required, as well as a correct helices-polar face orientation...
  36. pmc The crystal structure of the C-terminal truncated apolipoprotein A-I sheds new light on amyloid formation by the N-terminal fragment
    Olga Gursky
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118, United States
    Biochemistry 51:10-8. 2012
    ....
  37. ncbi Combined N- and C-terminal truncation of human apolipoprotein A-I yields a folded, functional central domain
    Jennifer A Beckstead
    Lipid Biology in Health and Disease Research Group, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, California 94609, USA
    Biochemistry 44:4591-9. 2005
    ..Lipid association likely results in a conformational adaptation wherein helix-helix contacts are substituted for helix-lipid interactions...
  38. ncbi APOA1/C3/A4 gene cluster variability and lipid levels in Brazilian children
    E de Franca
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
    Braz J Med Biol Res 38:535-41. 2005
    ..This finding is not unexpected because expression of the effect of these polymorphisms might depend on the interaction with environmental variables both internal and external to the individual...
  39. ncbi Associations of the apolipoprotein A-I gene polymorphism and serum lipid levels in the Guangxi Hei Yi Zhuang and Han populations
    Yiyang Li
    Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning 530021, P R China
    Int J Mol Med 21:753-64. 2008
    ..An association of the apoAI -75 bp G/A and serum TG, LDL-C and apoA-I levels in Hei Yi Zhuang and serum TG, HDL-C and apoB levels in Han was also observed in this study...
  40. pmc Hereditary apolipoprotein AI-associated amyloidosis in surgical pathology specimens: identification of three novel mutations in the APOA1 gene
    Magdalena Eriksson
    Department of Pathology, Charite University Hospital, Berlin, Germany
    J Mol Diagn 11:257-62. 2009
    ..Patients with alterations in codons 1 to 75 mostly develop hepatic and renal amyloidosis, while carriers of mutations in residues 173 to 178 mainly suffer from cardiac, laryngeal, and cutaneous amyloidosis...
  41. pmc Novel N-terminal mutation of human apolipoprotein A-I reduces self-association and impairs LCAT activation
    Paul M M Weers
    Department of Chemistry and Biochemistry, California State University Long Beach, Long Beach, CA, USA
    J Lipid Res 52:35-44. 2011
    ..These results implicate a region around S36 in apoA-I self-association, independent of the intact C terminus. Furthermore, the region around S36 in the N-terminus of human apoA-I is necessary for LCAT activation...
  42. ncbi Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles
    Charulatha Vedhachalam
    Division of Gastroenterology, Hepatology and Nutrition, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 282:25123-30. 2007
    ..Overall, this mechanism is consistent with the known properties of ABCA1 and apo A-I and reconciles many of the apparently discrepant findings in the literature...
  43. pmc Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor
    Rudo Kieft
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 107:16137-41. 2010
    ..We propose that the combination of coding sequence mutations and decreased expression of TbgHpHbR directly contribute to parasite evasion of human innate immunity and infectivity of group 1 T. b. gambiense...
  44. pmc Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma
    Rong Huang
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Nat Struct Mol Biol 18:416-22. 2011
    ..This understanding offers insights into how apoA-I structure modulates HDL function and its interactions with other apolipoproteins...
  45. pmc Crystal structure of C-terminal truncated apolipoprotein A-I reveals the assembly of high density lipoprotein (HDL) by dimerization
    Xiaohu Mei
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 286:38570-82. 2011
    ..Furthermore, the structure suggests the possible interaction with lecithin-cholesterol acyltransferase and may shed light on the molecular details of the effect of the Milano, Paris, and Fin mutations...
  46. pmc Conformational flexibility of the N-terminal domain of apolipoprotein a-I bound to spherical lipid particles
    Momoe Kono
    Department of Biophysical Chemistry, Kobe Pharmaceutical University, Kobe 658 8558, Japan
    Biochemistry 47:11340-7. 2008
    ....
  47. pmc Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication
    Daniel I Chasman
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Genet 1:21-30. 2008
    ....
  48. pmc Structure of apolipoprotein A-I N terminus on nascent high density lipoproteins
    Jens O Lagerstedt
    Department of Experimental Medical Science, Lund University, S 221 84 Lund, Sweden
    J Biol Chem 286:2966-75. 2011
    ..6 nm rHDL (residues 6-98) and identified residues in this region that are affected by particle size. We conclude that the inter-helical segment (residues 35-49) plays a role in the adaptation of apoA-I to the particle size of HDL...
  49. ncbi Association between MspI polymorphism of the APO AI gene and Type 2 diabetes mellitus
    S Morcillo
    Endocrinology and Nutrition Service, Hospital Carlos Haya, Malaga, Spain
    Diabet Med 22:782-8. 2005
    Genes of the Apo AI/CIII/AIV cluster on chromosome 11 have been related to plasma lipid patterns...
  50. ncbi Intermolecular contact between globular N-terminal fold and C-terminal domain of ApoA-I stabilizes its lipid-bound conformation: studies employing chemical cross-linking and mass spectrometry
    Shaila Bhat
    Pathology and Biochemistry, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Biol Chem 280:33015-25. 2005
    ....
  51. ncbi ABCA1-induced cell surface binding sites for ApoA-I
    Charulatha Vedhachalam
    Division of GI Nutrition, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    Arterioscler Thromb Vasc Biol 27:1603-9. 2007
    ..The purpose of this study was to understand the interactions of apoA-I with cells expressing ABCA1...
  52. ncbi Speciation of human plasma high-density lipoprotein (HDL): HDL stability and apolipoprotein A-I partitioning
    Henry J Pownall
    Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Biochemistry 46:7449-59. 2007
    ....
  53. doi Gene-nutrient interactions and gender may modulate the association between ApoA1 and ApoB gene polymorphisms and metabolic syndrome risk
    Catherine M Phillips
    Nutrigenomics Research Group, UCD Conway Institute, UCD School of Public Health and Population Science, University College Dublin, Belfield, Dublin 4, Ireland
    Atherosclerosis 214:408-14. 2011
    ..Dyslipidemia is a key feature of the metabolic syndrome (MetS), which is determined by both genetic and dietary factors...
  54. pmc Tristetraprolin-dependent post-transcriptional regulation of inflammatory cytokine mRNA expression by apolipoprotein A-I: role of ATP-binding membrane cassette transporter A1 and signal transducer and activator of transcription 3
    Kai Yin
    Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center, University of South China, Hengyang, 421001, China
    J Biol Chem 286:13834-45. 2011
    ..These results present not only a novel mechanism for the apoA-I-mediated inflammation suppression in macrophages but also provide new insights for developing strategies for modulating vascular inflammation and atherosclerosis...
  55. ncbi Polyunsaturated fatty acids modulate the effects of the APOA1 G-A polymorphism on HDL-cholesterol concentrations in a sex-specific manner: the Framingham Study
    Jose M Ordovas
    Nutrition and Genomics Laboratory, the Lipid Metabolism Laboratory and the Epidemiology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston 02111, USA
    Am J Clin Nutr 75:38-46. 2002
    ..The A allele was shown to be associated with higher HDL-cholesterol concentrations in some studies but not in others...
  56. ncbi Identification and structural ramifications of a hinge domain in apolipoprotein A-I discoidal high-density lipoproteins of different size
    J Nicholas Maiorano
    Department of Pathology and Laboratory Medicine, University of Cincinnati, 2120 East Galbraith Road, Cincinnati, Ohio 45237 0507, USA
    Biochemistry 43:11717-26. 2004
    ..From these results, we present a model for a putative hinge domain in the context of recent "belt" and "hairpin" models of apoA-I structure in discoidal HDL particles...
  57. pmc Methionine oxidation impairs reverse cholesterol transport by apolipoprotein A-I
    Baohai Shao
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:12224-9. 2008
    ..These observations implicate oxidation of a single Met in apoA-I in impaired LCAT activation, a critical early step in reverse cholesterol transport...
  58. ncbi Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes
    K Murao
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0682, USA
    J Biol Chem 272:17551-7. 1997
    ..An additional role in recognition of damaged cells is suggested by these studies...
  59. ncbi Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP)
    Minna Kärkkäinen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, Helsinki FIN 00251, Finland
    J Biol Chem 277:15413-8. 2002
    ..During or after the transfer of lipolytic surface remnants to HDL, PLTP is transferred to apoA-I-containing HDL particles and thereby becomes part of the low activity complex...
  60. ncbi Apolipoproteins A-1 and B and the likelihood of non-fatal stroke and myocardial infarction -- data from The Third National Health and Nutrition Examination Survey
    Adnan I Qureshi
    Department of Neurosurgery, State University of New York at Buffalo, NY 14209 1194, USA
    Med Sci Monit 8:CR311-6. 2002
    ..The measurement of plasma apolipoproteins (APO) has been proposed for predicting the risk of cardiovascular diseases. However, the association between APOs and stroke is not well defined...
  61. ncbi [Interaction of human apolipoprotein AI and HIV-1 envelope proteins with the native and recombinant CD4 receptors]
    L E Panin
    Vopr Virusol 48:24-6. 2003
    ....
  62. ncbi Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter
    Bassam Haidar
    Cardiovascular Genetics Laboratory, Division of Cardiology, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 279:9963-9. 2004
    ..These findings suggest that apoA-I may activate cAMP signaling through G protein-coupled ABCA1 transporter...
  63. ncbi Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages
    Katharina Gaus
    Macrophage Biology Group, Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    FASEB J 18:574-6. 2004
    ..We propose that cholesterol exported to apoA-1 from this major slow efflux pool derives from nonraft regions of the plasma membrane but that the interaction of apoA-1 with lipid rafts is necessary to stimulate this efflux...
  64. ncbi An association analysis between ApoA1 polymorphisms and the high-density lipoprotein (HDL) cholesterol level and myocardial infarction (MI) in Japanese
    Keisuke Shioji
    Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Japan
    J Hum Genet 49:433-9. 2004
    ..0145, OR=0.4955, 95% CI: 0.2746-0.8525). The ApoA1 T84C polymorphism is an important marker for the HDL-C level and may be a new risk marker for MI in Japanese...
  65. ncbi Apolipoprotein A1 gene polymorphisms at the -75 bp and +83/ 84 bp polymorphic sites in healthy Omanis compared with world populations
    Said Ali S Al-Yahyaee
    Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khoud 123, Sultanate of Oman
    Hum Biol 76:307-12. 2004
    ..We found the frequencies of M1- and M2- to be 0.22 and 0.067, respectively, in 150 healthy Omanis. These frequencies were compared to frequencies found in other world populations...
  66. ncbi Paraoxonase-1 promoter polymorphism C--107T and serum apolipoprotein AI interact to modulate serum paraoxonase-1 status
    Richard W James
    Clinical Diabetes Unit, Division of Endocrinology, Diabetes and Nutrition, University Hospital, 1211 Geneva 14, Switzerland
    Pharmacogenet Genomics 15:441-6. 2005
    ..The objective was to examine the hypothesis that modifications to paraoxonase-1 specific activity (SP, activity per unit mass peptide) could contribute to serum paraoxonase-1 status, a determinant of the clinical efficacy of the enzyme...
  67. pmc APOA1-75 G to A substitution associated with severe forms of CAD, lower levels of HDL and apoA-I among northern Indians
    S Chhabra
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India
    Dis Markers 21:169-74. 2005
    ..Our study, first of its kind from India, suggests that 'A' allele may contribute to severity of CAD and low levels of HDL and apoA-I. However, an in depth study with a larger set of sample is necessary...
  68. pmc Associations among race/ethnicity, ApoC-III genotypes, and lipids in HIV-1-infected individuals on antiretroviral therapy
    Andrea S Foulkes
    School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts, United States of America
    PLoS Med 3:e52. 2006
    ..However, the association of race/ethnicity, or candidate gene effects across race/ethnicity, with plasma lipid levels in HIV-1-infected individuals, has not been reported...
  69. ncbi Active plasma phospholipid transfer protein is associated with apoA-I- but not apoE-containing lipoproteins
    Marian C Cheung
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA
    J Lipid Res 47:1315-21. 2006
    ....
  70. ncbi Longitudinal analysis of haplotypes and polymorphisms of the APOA5 and APOC3 genes associated with variation in serum triglyceride levels: the Bogalusa Heart Study
    D Michael Hallman
    Human Genetics Center, University of Texas, Houston Health Science Center, Houston, TX 77225, USA
    Metabolism 55:1574-81. 2006
    ..However, the degree to which polymorphisms in the APOC3 and APOA5 genes may be independently associated with triglyceride levels remains to be determined...
  71. ncbi The structure of apolipoprotein A-I in high density lipoproteins
    W Sean Davidson
    Department of Pathology and Laboratory Medicine, University of Cincinnati, OH 45237, USA
    J Biol Chem 282:22249-53. 2007
  72. ncbi Bone morphogenetic protein-1 (BMP-1) cleaves human proapolipoprotein A1 and regulates its activation for lipid binding
    Phuonglan Chau
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143, USA
    Biochemistry 46:8445-50. 2007
    ..The decrease in circulating apo A1 levels that is characteristic of the response to inflammation and infection may be mediated, at least in part, via BMP-1 by this novel mechanism...
  73. ncbi Genetic association study of APOA1/C3/A4/A5 gene cluster and haplotypes on triglyceride and HDL cholesterol in a community-based population
    Kuo Liong Chien
    Institute of Preventive Medicine, School of Public Health, National Taiwan University, Taiwan
    Clin Chim Acta 388:78-83. 2008
    ....
  74. pmc Three-dimensional models of HDL apoA-I: implications for its assembly and function
    Michael J Thomas
    Department of Biochemistry, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 49:1875-83. 2008
    ..The combination of mass spectrometry, molecular modeling, molecular dynamic analysis, and small-angle X-ray diffraction has provided additional structural information on apoA-I folding that complements previous approaches...
  75. doi Endothelial lipase promotes apolipoprotein AI-mediated cholesterol efflux in THP-1 macrophages
    Guosong Qiu
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Providence Heart Lung Institute, Department of Pathology and Laboratory Medicine, University of British Columbia St Paul s Hospital, Vancouver, BC Canada
    Arterioscler Thromb Vasc Biol 29:84-91. 2009
    ..Endothelial lipase (EL) is expressed by macrophages within atherosclerotic lesions. We investigated the influence of EL expression on cholesterol efflux in macrophages...
  76. ncbi Apolipoprotein A-IMilano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I
    K H Weisgraber
    J Biol Chem 258:2508-13. 1983
  77. ncbi Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted
    S C Rall
    J Biol Chem 259:10063-70. 1984
    ..The functional defect is probably related to a disruption in the secondary and/or tertiary structure of the protein caused by the deletion of lysine 107 in the primary structure...
  78. ncbi Characterization of two new human apolipoprotein A-I variants: apolipoprotein A-I Tsushima (Trp-108-->Arg) and A-I Hita (Ala-95-->Asp)
    K Araki
    Department of Internal Medicine, School of Medicine, Fukuoka University, Japan
    Biochim Biophys Acta 1214:272-8. 1994
    ..The frequency of the A allele was 0.04: the substitution G to A at codon 37 did not affect the plasma concentrations of lipids and lipoproteins...
  79. ncbi Truncation of the amino terminus of human apolipoprotein A-I substantially alters only the lipid-free conformation
    D P Rogers
    Biochemistry Department, Southern Research Institute, Birmingham, Alabama 35209, USA
    Biochemistry 36:288-300. 1997
    ....
  80. ncbi Apolipoprotein specificity for lipid efflux by the human ABCAI transporter
    A T Remaley
    National Heart, Lung and Blood Institute, Bethesda, Maryland 20982, USA
    Biochem Biophys Res Commun 280:818-23. 2001
    ..In summary, ABCAI-mediated cellular binding of apolipoproteins and lipid efflux is not specific for only apoA-I but can also occur with other apolipoproteins that contain multiple amphipathic helical domains...
  81. ncbi Variations in the promoter region of the apolipoprotein A-1 gene influence plasma lipoprotein(a) levels in Asian Indian neonates from Singapore
    C K Heng
    Department of Paediatrics, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074
    Pediatr Res 49:514-8. 2001
    ..Our results showed that there is significant ethnic- and gender-specific influence of the apoA1 gene on plasma Lp(a) levels at birth that is inherent and independent of known gene-environment interactions...
  82. ncbi Apolipoprotein A-I induces translocation of cholesterol, phospholipid, and caveolin-1 to cytosol in rat astrocytes
    Jin Ichi Ito
    Biochemistry, Cell Biology, and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Biol Chem 277:7929-35. 2002
    ....
  83. pmc Macrophage metalloproteinases degrade high-density-lipoprotein-associated apolipoprotein A-I at both the N- and C-termini
    Ivano Eberini
    Dipartimento di Scienze Farmacologiche, Universita degli Studi di Milano, via G Balzaretti, 9, I 20133 Milan, Italy
    Biochem J 362:627-34. 2002
    ..Proteolytic fragments produced by metalloproteinase action were shown by gel filtration and electrophoresis to be neither associated with lipids nor self-associated...
  84. ncbi Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis
    Helen J Lachmann
    National Amyloidosis Centre, Department of Medicine, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    N Engl J Med 346:1786-91. 2002
    ....
  85. ncbi Relationships among apolipoprotein A1 gene polymorphisms, lipid levels and coronary atherosclerosis disease
    Yangchun Zou
    Heart Center, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing 100020, China
    Chin Med J (Engl) 116:665-8. 2003
    ..To investigate the relationship among -75 bp/+83 bp polymorphism in apolipoprotein A1 (apo A1) gene, lipids levels and the occurrence of coronary atherosclerosis disease (CAD)...
  86. ncbi Phospholipid transfer protein interacts with and stabilizes ATP-binding cassette transporter A1 and enhances cholesterol efflux from cells
    John F Oram
    Department of Medicine, University of Washington, Seattle, Washington 98195 6426, USA
    J Biol Chem 278:52379-85. 2003
    ..Thus, PLTP mimics apolipoproteins in removing cellular lipids by the ABCA1 pathway, except that PLTP acts more as an intermediary in the transfer of cellular lipids to lipoprotein particles...
  87. ncbi Formation and metabolism of prebeta-migrating, lipid-poor apolipoprotein A-I
    Kerry Anne Rye
    Heart Research Institute, Camperdown, Sydney, NSW, Australia
    Arterioscler Thromb Vasc Biol 24:421-8. 2004
    ..This review describes current knowledge regarding the formation, metabolism, and regulation of monomolecular, lipid-free/lipid-poor apoA-I in plasma...
  88. ncbi Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1)
    Maxime Denis
    Cardiovascular Genetics Laboratory, Cardiology Division, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 279:7384-94. 2004
    ..This process plays in vivo a key role in HDL biogenesis...
  89. ncbi Multiple rare alleles contribute to low plasma levels of HDL cholesterol
    Jonathan C Cohen
    Donald W Reynolds Cardiovascular Clinical Research Center and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA
    Science 305:869-72. 2004
    ..Thus, rare alleles with major phenotypic effects contribute significantly to low plasma HDL-C levels in the general population...
  90. ncbi Conformation and lipid binding of the N-terminal (1-44) domain of human apolipoprotein A-I
    Hongli L Zhu
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Biochemistry 43:13156-64. 2004
    ..The helix length of 5 [1-44]apoA-I molecules in lipid-bound form is just long enough to wrap around the DMPC bilayer disk once...
  91. ncbi Association of two apolipoprotein A-I gene MspI polymorphisms with lipid and blood pressure levels
    Yan Qing Ma
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Int J Cardiol 102:309-14. 2005
    ..Two MspI polymorphisms in the ApoA-I gene (G-75A and C83T) have been shown to be associated with plasma HDL-cholesterol levels...
  92. ncbi High-density lipoprotein (HDL) transport in the metabolic syndrome: application of a new model for HDL particle kinetics
    Juying Ji
    Lipoprotein Research Unit, School of Medicine and Pharmacology, Royal Perth Hospital, Box X2213 GPO, Perth, WA 6847, Australia
    J Clin Endocrinol Metab 91:973-9. 2006
    ....
  93. ncbi Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I
    Phu T Duong
    Division of GI Nutrition, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Lipid Res 47:832-43. 2006
    ..The cellular PLs and cholesterol incorporated into these nascent HDL particles originate from different cell membrane domains...
  94. pmc Crystal structure of human apolipoprotein A-I: insights into its protective effect against cardiovascular diseases
    A Abdul Ajees
    Center for Biophysical Sciences and Engineering and Atherosclerosis Research Unit and Department of Medicine, University of Alabama, 1530 3rd Avenue South, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 103:2126-31. 2006
    ..This structure provides a much-needed structural template for exploration of molecular mechanisms by which human apoA-I ameliorates atherosclerosis and inflammatory diseases...
  95. ncbi Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein A-I
    Baohai Shao
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 281:9001-4. 2006
    ....
  96. ncbi Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues
    J T J Huang
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Mol Psychiatry 13:1118-28. 2008
    ..05; -51%, P=0.05). These results show that apoA1 is consistently downregulated in the central nervous system as well as peripheral tissues of schizophrenia patients and may be linked to the underlying disease mechanism...
  97. ncbi Normal vascular function despite low levels of high-density lipoprotein cholesterol in carriers of the apolipoprotein A-I(Milano) mutant
    Monica Gomaraschi
    Center Grossi Paoletti, Department of Pharmacological Sciences, University of Milano, Italy
    Circulation 116:2165-72. 2007
    ..Whether the low HDL level of apoA-I(M) carriers is associated with impaired vascular function is presently unknown...
  98. pmc ATP-binding cassette A1-mediated lipidation of apolipoprotein A-I occurs at the plasma membrane and not in the endocytic compartments
    Maxime Denis
    Ottawa Health Research Institute, and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ontario K1Y 4E9, Canada
    J Biol Chem 283:16178-86. 2008
    ..We therefore conclude that the plasma membrane is the main platform where ABCA1-mediated lipidation of apoA-I occurs...
  99. pmc Cholesterol is a determinant of the structures of discoidal high density lipoproteins formed by the solubilization of phospholipid membranes by apolipoprotein A-I
    John B Massey
    Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Biochim Biophys Acta 1781:245-53. 2008
    ..The size speciation of rHDL and probably nascent HDL formed via the activity of the ABCA1 lipid transporter is mechanistically linked to the cholesterol content of the membranes from which they were formed...
  100. pmc Initial interaction of apoA-I with ABCA1 impacts in vivo metabolic fate of nascent HDL
    Anny Mulya
    Department of Pathology, Wake Forest University Health Sciences, Winston Salem, NC, USA
    J Lipid Res 49:2390-401. 2008
    ....
  101. pmc Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes
    R A Gangani D Silva
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45237, USA
    Proc Natl Acad Sci U S A 105:12176-81. 2008
    ..We propose the first experiment-based molecular model of apoA-I in spherical HDL particles. This model provides a new foundation for understanding how apoA-I structure modulates HDL function and metabolism...

Research Grants63

  1. ANTONIO PAUL; Fiscal Year: 2014
    ....
  2. Hong Wang; Fiscal Year: 2016
    ..If the key steps in Hcy-induced dyslipidemia and atherosclerosis can be identified, new genetic or pharmacological therapeutic targets can be utilized for treatment. ..
  3. Unraveling the Genetic Architecture of Very High HDL cholesterol though Transcrip
    Michael Miller; Fiscal Year: 2010
    ..It is hoped that the identification of novel genes implicated in high HDL states that are associated with longevity will facilitate the development of novel therapies aimed at reducing heart disease. ..
  4. Regulation of Macrophage Reverse Cholesterol Transport by BRCA1
    Ira G Schulman; Fiscal Year: 2013
    ....
  5. Role of H3K4 methylation in transcriptional activation by FoxA
    Janice M Ascano; Fiscal Year: 2010
    ..This proposal will focus on a protein that controls expression of these genes in the liver and aim to work out the detailed mechanisms of its action. ..
  6. Alice S Chen-Plotkin; Fiscal Year: 2016
    ....
  7. HYPERAPOLIPOPROTEIN B AND CORONARY ARTERY DISEASE
    Peter Kwiterovich; Fiscal Year: 1991
    ....
  8. MOLECULAR ASPECTS OF AMYLOIDOSIS
    WARREN LIAO; Fiscal Year: 1999
    ..to study the pathogenesis of secondary amyloidosis using a transgenic animal model. ..
  9. Yury Miller; Fiscal Year: 2014
    ....
  10. Safe and Efficacious Non-viral Vectors for Gene Therapy
    Leaf Huang; Fiscal Year: 2007
    ..The resulting plasmid should be more active in gene expression. The goal is to design safer and more efficacious non-viral vectors for gene therapy. ..
  11. Ann Marie Schmidt; Fiscal Year: 2016
    ..Taken together, this work will uncover novel therapeutic strategies to enhance HDL function and cardiovascular health. ..
  12. ApoA1 Determining HDL Subclasses and Atherosclerosis
    GODFREY GETZ; Fiscal Year: 2006
    ..The final specific aim will examine how the mutants or the engineered HDLs generated in vivo interact with enzymes and receptors that are involved in HDL remodeling and cholesterol efflux. ..
  13. Carlos Fernandez Hernando; Fiscal Year: 2016
    ....
  14. Zahi A Fayad; Fiscal Year: 2016
    ..Robert Langer (MIT), a pioneer in nanoparticle therapeutics development, and Prof. Edward Fisher (NYU), a widely-recognized researcher in lipoprotein metabolism and atherosclerosis. ..
  15. CHOLESTEROL TRANSPORT IN GALLBLADDER EPITHELIAL CELLS
    Rahul Kuver; Fiscal Year: 2003
    ..3. Compare and contrast the mechanisms of activation of ABCA1 via the cAMP responsive and the LXRalpha/RXR- responsive pathways. ..
  16. Trial of mesna to prevent doxorubicin-induced plasma protein oxidation and TNFa r
    Jeffrey A Moscow; Fiscal Year: 2012
    ....
  17. JEFFREY JOHN BAZARIAN; Fiscal Year: 2015
    ..The PIs propose to examine changes in the blood and spinal fluid to learn more about mild TBI. In the process they hope to train and inspire a new generation of clinical researchers interested in traumatic brain injury. ..
  18. TRANSTHYRETIN DEPOSITION IN AGING TRANSGENIC MICE
    Joel Buxbaum; Fiscal Year: 2004
    ..Investigation of the model may allow us to identify and study such mechanisms which, in turn, may provide insight into aging and offer potential therapeutic targets in more than one form of human amyloidosis. ..
  19. RECOMBINANT PHARMACETICAL PROTEIN PRODUCTION IN EGGS
    Clague Hodgson; Fiscal Year: 1993
    ....
  20. Estrogen, HDL, and coronary heart disease in women
    Stefania Lamon Fava; Fiscal Year: 2005
    ..The proposed analyses provide a unique opportunity to shed light on the physiological role of HDL subpopulations and HRT on CHD in women. ..
  21. Apolipoprotein-mediated cholesterol efflux
    W Davidson; Fiscal Year: 2008
    ..This understanding will form a basis for new interventions designed to enhance apolipoprotein-mediated cholesterol efflux from cells, particularly those within the atherosclerotic vessel wall. ..
  22. Arg199: key player in electron transfer in NOS enzyme
    Valentin Gogonea; Fiscal Year: 2004
    ..Primary focus is placed on how Arg199 modulates the electron transfer in NOS a role only revealed during the dynamics of the system. ..
  23. The roles of apolipoprotein A-IV structure and lipid affinity in its function
    W Davidson; Fiscal Year: 2009
    ....
  24. ABCA1, ApoAI, and Lipid Efflux
    Jonathan Smith; Fiscal Year: 2008
    ..In addition, this study will include the identification of the apoAl oxidative modification by the enzyme myeloperoxidase that diminishes its lipid acceptor activity. ..
  25. Identifying Kidney Disease Genes Through Mutagenesis
    RONNY KORSTANJE; Fiscal Year: 2009
    ....
  26. STRUCTURAL THERMODYNAMICS OF HUMAN APOLIPOPROTEIN C 1
    Olga Gursky; Fiscal Year: 2002
    ....
  27. IN VIVO NMR OF TUMORS AND THEIR RESPONSE TO CHEMOTHERAPY
    Jerry Glickson; Fiscal Year: 2002
    ..Pilot 1H MRS studies will be performed on human subjects with carcinoma of the breast to compare the characteristics of these tumors with those of the model tumors before treatment and after chemotherapy (of breast tumor metastases). ..
  28. A High-Resolution Enhancer Atlas of the Developing Forebrain
    LEN ALEXANDER PENNACCHIO; Fiscal Year: 2010
    ..These studies are likely to have implications in defining the role of these switches for normal brain function and how they go awry in human brain diseases. ..
  29. Genes, Hormomes, Growth, and Body Fat: Project HeartBeat
    DAVID MICHAEL HALLMAN; Fiscal Year: 2010
    ..Our analyses may also help identify genetic variants that may predispose some individuals toward obesity. ..
  30. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose M Ordovas; Fiscal Year: 2010
    ..This evidence-based knowledge will contribute to a rational approach toward more effective dietary recommendations aimed to decrease health disparities and to a better CVD prevention. ..
  31. Genotypes, Haplotypes, and Blood Pressure Change from Childhood to Adulthood
    DAVID MICHAEL HALLMAN; Fiscal Year: 2010
    ....
  32. GENETIC EPIDEMIOLOGY OF CHANGE IN CVD RISK FACTORS
    DAVID MICHAEL HALLMAN; Fiscal Year: 2010
    ....
  33. The altered lipid and protein metabolism of pediatric patients with HIV infection
    Farook Jahoor; Fiscal Year: 2010
    ..Knowledge gained from this project may lead to new nutritional therapies to help prevent these conditions. ..
  34. Structure of apolipoprotein A-I on defined states of HDL
    MICHAEL NOBUAKI ODA; Fiscal Year: 2010
    ..Additionally, an enhanced understanding of apoA-I structure and HDL function will illuminate the cause of disease through dysfunction of HDL or apoA-I. ..
  35. ENZYMATIC REACTIONS OF PLASMA LIPOPROTEINS
    Henry J Pownall; Fiscal Year: 2010
    ....
  36. Aromatic amino acid metabolism in the pathogenesis of kwashiorkor
    Farook Jahoor; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  37. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard B Weinberg; Fiscal Year: 2010
    ..We believe that these studies will provide new knowledge on the function of apo A-IV in the complex process of lipoprotein assembly relevant to the dietary control of atherosclerotic cardiovascular disease and obesity. ..
  38. MID-ATLANTIC IN VIVO CELLULAR & MOLECULAR IMAGING CENTER
    Jerry Glickson; Fiscal Year: 2002
    ..The MAMIC will therefore serve as a catalyst and focal point for ongoing cancer research employing state of the art imaging techniques. ..
  39. NMR PREDICTION AND MONITORING OF RADIATION RESPONSE
    Jerry Glickson; Fiscal Year: 2002
    ..The possibility that glycolytic rate is predictive for solid tumor radiosensitivity for different tumor cell lines and steady state lactate concentration is predictive within a cell line will be examined. ..
  40. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    JANICE WAGNER; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  41. MOLECULAR BASIS FOR APOLIPOPROTEIN AI FUNCTION
    Christie Brouillette; Fiscal Year: 2002
    ..In the long term, these studies will help determine which of the competing models may be physiologically relevant and help us understand lipid and cholesterol metabolism. ..
  42. DEMENTIA IN SWEDISH TWINS
    Margaret Gatz; Fiscal Year: 2002
    ..Different diagnostic criteria will be compared. Quantitative indices will be derived from neuropsychological scores and from neuroimaging data subjected to quantitative mapping. ..
  43. Neonatal Nutrition and the Genetics of Human Lactation
    Richard Weinberg; Fiscal Year: 2003
    ..This knowledge could eventually enable the identification of women who require specific fatty acid or vitamin supplementation to assure optimal infant nutrition. ..
  44. MOLECULAR & CLINICAL EVALUATION OF LOW HDL SYNDROMES
    Michael Miller; Fiscal Year: 2003
    ..Further understanding of the molecular basis of isolated low HDL-C and its potential clinical sequelae (e.g., CAD), may therefore aid in the development of therapeutic strategies to effectively treat this disorder. ..
  45. TEACHING NUTRITION TO PREVENT CARDIOVASCULAR DISEASES
    Francine Welty; Fiscal Year: 2004
    ..This career award will establish Dr. Walker as a leader in medical education in nutrition, his long-term career goal. ..
  46. GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPS
    Sharon Kardia; Fiscal Year: 2004
    ..The resulting synthesis of ideas and amassed data permits rigorous hypothesis testing not otherwise possible and will hasten understanding of the previously elusive genetic variation responsible for disease risk. ..
  47. Negotiating Complexity: Common Disease & Diverse Genomes
    STEPHANIE FULLERTON; Fiscal Year: 2004
    ..Research methods will include extensive archival research (of both primary data reports and related press coverage) as well as semi-structured interviews with human geneticists. ..
  48. NUTRITION ACADEMIC AWARD
    Michael Miller; Fiscal Year: 2004
    ..Compliance with ATP II and JNC VI recommendations will also be assessed. In addition, medical students' diets and blood lipid levels will be assessed and tracked. ..
  49. Atherogenic Effects of Tyrosine Oxidation in HDL
    John Oram; Fiscal Year: 2004
    ....
  50. Genetic Predictors of Incident CVD
    Sharon Kardia; Fiscal Year: 2005
    ..abstract_text> ..
  51. Vitamin K: Genetics of Vascular Calcification
    Jose Ordovas; Fiscal Year: 2005
    ..This research should provide the basis for more comprehensive genetic studies aimed to provide better identification of risk and more precise therapeutic approaches for these age-related disorders. ..
  52. Genomic Predictors of Arteriosclerosis in Hypertensives
    Sharon Kardia; Fiscal Year: 2009
    ..End of Abstract) ..
  53. Genetic and Genomic Analysis of apoAV
    Len Pennacchio; Fiscal Year: 2006
    ..abstract_text> ..
  54. ApoB and ApoA-I Kinetics in the ApoB-67 Mutation
    Francine Welty; Fiscal Year: 2006
    ..The apoB-67 mutation may provide insights into mechanisms of low LDL-C and high HDL-C levels and new and better therapies to lower cholesterol. ..
  55. Novel Gene Therapy using Helper-Dependent Adenovirus
    Kazuhiro Oka; Fiscal Year: 2006
    ..abstract_text> ..
  56. Physiogenomic Arrays for Clinical Neuropsychiatry
    GUALBERTO RUANO; Fiscal Year: 2006
    ..The program will develop NeuroPsych Gene Array products as a new tool for systems understanding of neuropsychiatric and neurodegenerative diseases leading to early diagnosis and personalized therapy. [unreadable] [unreadable]..
  57. A Twin Study of Cognitive Outcomes in Older Adult Cancer
    Margaret Gatz; Fiscal Year: 2006
    ..Through abstracting data from cancer treatment records and linking them to existing datasets, we will be able to examine possible longer term effects, along with likely covariates, with optimal comparison groups. ..
  58. 2006 Lipoprotein Metabolism Gordon Conference
    MARY SORCI THOMAS; Fiscal Year: 2006
    ....
  59. Genomic dissection of a QTL affecting the lipid profile
    Michael Olivier; Fiscal Year: 2007
    ..abstract_text> ..
  60. GENETIC DETERMINANTS OF PLASMA LIPOPROTEINS
    Jonathan Cohen; Fiscal Year: 2002
    ..These studies will help to determine the role of variation in hepatic lipase activity in determining plasma HDL concentrations, and LDL size distribution, two important risk factors for coronary artery disease. ..
  61. Dementia in Swedish Twins Data Archiving
    Margaret Gatz; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  62. PAT PROTEINS: GENE-DIET INTERACTIONS OBESITY RISK AND HEALTH
    Jose Ordovas; Fiscal Year: 2009
    ....
  63. Methods for high-dimensional data in HIV research
    Andrea Foulkes; Fiscal Year: 2009
    ....

Patents1

  1. Expression of human proapolipoprotein A-1
    Patent Number: EP0293357-A1; Date:1988-11-30