APC

Summary

Gene Symbol: APC
Description: APC, WNT signaling pathway regulator
Alias: BTPS2, DP2, DP2.5, DP3, PPP1R46, adenomatous polyposis coli protein, WNT signaling pathway regulator, adenomatosis polyposis coli tumor suppressor, deleted in polyposis 2.5, protein phosphatase 1, regulatory subunit 46, truncated adenomatosis polyposis coli
Species: human

Top Publications

  1. ncbi Screening for germ-line mutations in familial adenomatous polyposis patients: 61 new patients and a summary of 150 unrelated patients
    H Nagase
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mutat 1:467-73. 1992
  2. ncbi The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin
    Jing Liu
    Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
    J Mol Biol 360:133-44. 2006
  3. doi Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer
    Karim Bougatef
    Laboratory of Human Genetics, Immunology, and Pathology, Faculty of Sciences Tunis, University of Tunis, Campus Universitaire, El Manar I, Tunis 2092, Tunisia
    Cancer Genet Cytogenet 187:12-8. 2008
  4. pmc Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection
    Ian P Newton
    Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Mol Biol Cell 21:3630-8. 2010
  5. ncbi Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene
    Y Miyoshi
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mol Genet 1:229-33. 1992
  6. ncbi Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells
    Jun Yang
    Sealy Center for Cancer Cell Biology and Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Biol Chem 281:17751-7. 2006
  7. doi Long interspersed nuclear element 1 hypomethylation is a marker of poor prognosis in stage IA non-small cell lung cancer
    Kenichiro Saito
    Division of Translational and Clinical Oncology, Molecular and Cellular Targeting Translational Oncology Center, Cancer Research Institute, Kanazawa University, Japan
    Clin Cancer Res 16:2418-26. 2010
  8. ncbi Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma
    Soichi Iwai
    Department of Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry, 1 8, Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Cancer Res Clin Oncol 131:773-82. 2005
  9. ncbi High promoter methylation levels of APC predict poor prognosis in sextant biopsies from prostate cancer patients
    Rui Henrique
    Department of Pathology, Portuguese Oncology Institute Porto, Portugal
    Clin Cancer Res 13:6122-9. 2007
  10. pmc Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex
    Hoanh Tran
    Department of Cancer Targets, Genentech Inc, South San Francisco, California 94080, USA
    J Biol Chem 287:28552-63. 2012

Research Grants

  1. Ontogeny and function of zebrafish antigen presenting cells
    David Traver; Fiscal Year: 2011
  2. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
  3. Klaus F Ley; Fiscal Year: 2016
  4. Astrid E Cardona; Fiscal Year: 2016
  5. CYTOTOXIC T CELL RESPONSES TO HHV-8
    Charles R Rinaldo; Fiscal Year: 2013
  6. David Q Shih; Fiscal Year: 2016
  7. Haochu Huang; Fiscal Year: 2015
  8. Pavan Reddy; Fiscal Year: 2016
  9. Shannon J Turley; Fiscal Year: 2016
  10. UBIQUITIN-DEPENDENT REGULATION OF IMMUNE ACTIVATION
    Lonnie P Lybarger; Fiscal Year: 2010

Detail Information

Publications322 found, 100 shown here

  1. ncbi Screening for germ-line mutations in familial adenomatous polyposis patients: 61 new patients and a summary of 150 unrelated patients
    H Nagase
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mutat 1:467-73. 1992
    We report here the result of a screening for germ-line mutations in the adenomatous polyposis coli (APC) gene in 61 new familial adenomatous polyposis (FAP) patients as well as a summary of the results of 150 patients...
  2. ncbi The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin
    Jing Liu
    Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
    J Mol Biol 360:133-44. 2006
    Adenomatous polyposis coli (APC) plays a critical role in the Wnt signaling pathway by tightly regulating beta-catenin turnover and localization...
  3. doi Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer
    Karim Bougatef
    Laboratory of Human Genetics, Immunology, and Pathology, Faculty of Sciences Tunis, University of Tunis, Campus Universitaire, El Manar I, Tunis 2092, Tunisia
    Cancer Genet Cytogenet 187:12-8. 2008
    Sporadic colorectal tumorigenesis is caused by alterations in the Wnt (APC, CTNNB1) and Ras pathways. Our objective was to analyze the occurrence of these genetic alterations in relation to tumor and patient characteristics...
  4. pmc Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection
    Ian P Newton
    Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Mol Biol Cell 21:3630-8. 2010
    The tumor suppressor adenomatous polyposis coli (APC) is mutated in the majority of colorectal cancers and is best known for its role as a scaffold in a Wnt-regulated protein complex that determines the availability of β-catenin...
  5. ncbi Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene
    Y Miyoshi
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mol Genet 1:229-33. 1992
    We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas) developed in familial adenomatous polyposis (FAP) and non-FAP patients...
  6. ncbi Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells
    Jun Yang
    Sealy Center for Cancer Cell Biology and Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Biol Chem 281:17751-7. 2006
    Most colorectal cancers have mutations of the adenomatous polyposis coli (APC) gene or the beta-catenin gene that stabilize beta-catenin and activate beta-catenin target genes, leading ultimately to cancer...
  7. doi Long interspersed nuclear element 1 hypomethylation is a marker of poor prognosis in stage IA non-small cell lung cancer
    Kenichiro Saito
    Division of Translational and Clinical Oncology, Molecular and Cellular Targeting Translational Oncology Center, Cancer Research Institute, Kanazawa University, Japan
    Clin Cancer Res 16:2418-26. 2010
    ..The aim of this study was to evaluate the prognostic significance of both global hypomethylation and gene promoter hypermethylation in DNA from non-small cell lung cancer (NSCLC)...
  8. ncbi Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma
    Soichi Iwai
    Department of Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry, 1 8, Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Cancer Res Clin Oncol 131:773-82. 2005
    The Wnt pathway is involved in carcinogenesis and three regulatory genes of the Wnt pathway, APC, beta-catenin and Axin are mutated in some primary human cancers...
  9. ncbi High promoter methylation levels of APC predict poor prognosis in sextant biopsies from prostate cancer patients
    Rui Henrique
    Department of Pathology, Portuguese Oncology Institute Porto, Portugal
    Clin Cancer Res 13:6122-9. 2007
    ....
  10. pmc Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex
    Hoanh Tran
    Department of Cancer Targets, Genentech Inc, South San Francisco, California 94080, USA
    J Biol Chem 287:28552-63. 2012
    The adenomatous polyposis coli (APC) tumor suppressor forms a complex with Axin and GSK3β to promote the phosphorylation and degradation of β-catenin, a key co-activator of Wnt-induced transcription...
  11. pmc Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription
    Rina Rosin-Arbesfeld
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    EMBO J 22:1101-13. 2003
    The adenomatous polyposis coli (APC) protein is inactivated in most colorectal tumours. APC loss is an early event in tumorigenesis, and causes an increase of nuclear beta-catenin and its transcriptional activity...
  12. pmc Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer
    Gillian Smith
    Cancer Research United Kingdom Molecular Pharmacology Unit, Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Proc Natl Acad Sci U S A 99:9433-8. 2002
    ..proposed in which the sequential accumulation of mutations in specific genes, including adenomatous polyposis coli (APC), Kirsten-ras (K-ras), and p53, drives the transition from healthy colonic epithelia through increasingly ..
  13. doi Novel self-association of the APC molecule affects APC clusters and cell migration
    Zhuoyu Li
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, WTB MSI Complex, Dundee, UK
    J Cell Sci 121:1916-25. 2008
    Truncation mutations in the adenomatous polyposis coli (APC) gene are responsible for familial and sporadic colorectal cancer. APC is a multifunctional protein involved in cell migration, proliferation and differentiation...
  14. ncbi The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase
    T Ishidate
    Department of Oncogene Research, Institute for Microbial Diseases, Osaka University, Suita, Japan
    Oncogene 19:365-72. 2000
    The adenomatous polyposis coli (APC) gene is mutated in familial adenomatous polyposis and in many sporadic colorectal tumors...
  15. pmc Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation
    Lilia Topol
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 162:899-908. 2003
    ..This pathway is Siah2 and APC dependent, but GSK-3 and beta-TrCP independent...
  16. ncbi Quantitative, spatial resolution of the epigenetic field effect in prostate cancer
    Jyoti Mehrotra
    Veridex LLC, a Johnson and Johnson Company, Warren, New Jersey, USA
    Prostate 68:152-60. 2008
    ..We tested this hypothesis using molecular techniques to detect epigenetic changes in the primary tumor and surrounding tissues...
  17. ncbi APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance
    Jan Sing Hsieh
    Department of Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan
    Am Surg 71:336-43. 2005
    ..the sequential accumulation of mutations in specific cancer-related genes, including adenomatous polyposis coli (APC), K-ras, and p53, drives the transition from normal epithelium through increasing adenomatous dysplasia to ..
  18. pmc Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells
    V M Draviam
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    EMBO J 25:2814-27. 2006
    ..We find that RNAi-mediated depletion of two kMAPs, the adenomatous polyposis coli protein (APC) and its binding partner, EB1, are unusual in affecting the movement and orientation of paired ..
  19. pmc APC promoter methylation and protein expression in hepatocellular carcinoma
    Antal Csepregi
    Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Cancer Res Clin Oncol 134:579-89. 2008
    We investigated the impact of promoter methylation on APC protein expression in patients with hepatocellular carcinoma (HCC).
  20. pmc Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    S Ikeda
    Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    EMBO J 17:1371-84. 1998
    ..These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin...
  21. ncbi Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A
    J M Seeling
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA
    Science 283:2089-91. 1999
    ..The adenomatous polyposis coli (APC) protein, axin, and glycogen synthase kinase 3beta form a Wnt-regulated signaling complex that mediates the ..
  22. ncbi Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein
    J Liu
    Department of Oncological Sciences, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Mol Cell 7:927-36. 2001
    The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and GSK3beta, forms a Wnt-regulated signaling complex that mediates phosphorylation-dependent degradation of beta-catenin by the proteasome...
  23. ncbi Clinical and genetic findings in an Ashkenazi Jewish population with colorectal neoplasms
    N Peter Zauber
    Department of Medicine, Saint Barnabas Medical Center, Livingston, New Jersey, USA
    Cancer 104:719-29. 2005
    ..authors evaluated the frequency of the carrier status of three ancestral colorectal neoplasm-associated mutations (APC:I1307K, BLM(Ash), and MSH2*1906G>C) found in the Jewish population among a case series with documented ..
  24. ncbi Somatic APC mosaicism: a frequent cause of familial adenomatous polyposis (FAP)
    Stefan Aretz
    Institute of Human Genetics, University Hospital of Bonn, Bonn, Germany
    Hum Mutat 28:985-92. 2007
    ..During APC mutation screening in 1,248 unrelated patients with familial adenomatous polyposis (FAP), we identified 75 cases ..
  25. doi Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours
    Eva Maria Kohler
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 17:1978-87. 2008
    The mutation cluster region (MCR) of adenomatous polyposis coli (APC) is located within the central part of the open reading frame, overlapping with the region encoding the 20 amino acid repeats (20R) that are beta-catenin-binding sites...
  26. ncbi Expression of the proliferating cell nuclear antigen and protein products of tumour suppressor genes in the human foetal testis
    S Maric
    Department of Biology, School of Medicine, University of Osijek, Osijek, Croatia
    Andrologia 36:24-30. 2004
    Tumour suppressor genes retinoblastoma (Rb1) and adenomatous polyposis coli (Apc) as well as the proliferating cell nuclear antigen (PCNA) are involved in embryonic development...
  27. ncbi Maternal mosaicism for a second mutational event--a novel deletion--in a familial adenomatous polyposis family harboring a new germ-line mutation in the alternatively spliced-exon 9 region of APC
    Sima Davidson
    Molecular Oncology Laboratory, Rambam Medical Center, Haifa, Israel
    Hum Mutat 19:83-4. 2002
    ..Familial Adenomatous Polyposis (FAP) is an autosomal dominant heritable disorder caused by germ-line mutations in the APC gene. To date, more than 300 germ-line mutations within this gene have been described...
  28. ncbi Different familial adenomatous polyposis phenotypes resulting from deletions of the entire APC exon 15
    Li Kuo Su
    Department of Molecular and Cellular Oncology, Box 79, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston 77030, USA
    Hum Genet 111:88-95. 2002
    Germline mutations of the adenomatous polyposis coli ( APC) gene cause familial adenomatous polyposis (FAP), an autosomal, dominantly inherited disease that predisposes patients to colorectal cancer...
  29. ncbi Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
    Nam Chul Ha
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94043, USA
    Mol Cell 15:511-21. 2004
    ..occurs in a multiprotein complex that includes the kinases, beta-catenin, axin, and the Adenomatous Polyposis Coli (APC) protein. The role of APC in this process is poorly understood...
  30. pmc APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment
    Rebecca A Green
    Section of Molecular and Cellular Biology, University of California Davis, Davis, CA 95616, USA
    Mol Biol Cell 16:4609-22. 2005
    Recently, we have shown that a cancer causing truncation in adenomatous polyposis coli (APC) (APC(1-1450)) dominantly interferes with mitotic spindle function, suggesting APC regulates microtubule dynamics during mitosis...
  31. pmc Switch of transforming growth factor beta function from tumor suppression to stimulation in adenomatous polyposis coli (APC) knocked-down human colon carcinoma cells
    Hongmei Wang
    Department of Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine and SimmonsCooper Cancer Institute, Springfield, IL 62794 9677, United States
    Cancer Lett 272:253-9. 2008
    ..Both the CBS and Moser cells were found to express mutant (truncated) APC. Expression of this form of APC did not interfere with the tumor-suppressive function of TGFbeta...
  32. pmc Molecular basis for the recognition of adenomatous polyposis coli by the Discs Large 1 protein
    Zhenyi Zhang
    State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
    PLoS ONE 6:e23507. 2011
    ..uses two of its three PDZ domains to interact with the C-terminal peptide of the Adenomatous Polyposis Coli (APC) tumor suppressor protein...
  33. ncbi IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli
    Manisha Sharma
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 282:8545-56. 2007
    ..that beta-catenin co-localizes with IQ-domain GTPase-activating protein 1 (IQGAP1), adenomatous polyposis coli (APC), and N-cadherin at actin-positive membrane ruffles in NIH 3T3 fibroblasts...
  34. doi Clinical and genetic characterization of classical forms of familial adenomatous polyposis: a Spanish population study
    B Rivera
    Centro de Investigaciones Biomédicas en Red de Enfermedades Raras CIBERER, Valencia, Spain
    Ann Oncol 22:903-9. 2011
    ..Classical familial adenomatous polyposis (FAP) is characterized by the appearance of >100 colorectal adenomas...
  35. ncbi Hot spots in beta-catenin for interactions with LEF-1, conductin and APC
    J P von Kries
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13093 Berlin, Germany
    Nat Struct Biol 7:800-7. 2000
    Interactions between beta-catenin and LEF-1/TCF, APC and conductin/axin are essential for wnt-controlled stabilization of beta-catenin and transcriptional activation...
  36. ncbi Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC
    Ursula Kurzik-Dumke
    Institute of Medical Microbiology and Hygiene, Laboratory for Comparative Tumor Biology, Johannes Gutenberg University, Obere Zahlbacher Strasse 63, 55131 Mainz, Germany
    Cell Signal 19:1973-85. 2007
    ..we provide evidence for the association of the endogenous Tid50/Tid48 proteins with the adenomatous polyposis coli (APC) tumor suppressor in normal colon epithelium, colorectal cancer cells and mouse NIH3T3 fibroblasts...
  37. pmc The mitochondrial protein hTID-1 partners with the caspase-cleaved adenomatous polyposis cell tumor suppressor to facilitate apoptosis
    Jiang Qian
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University College of Medicine, Columbus, Ohio 43210 2207, USA
    Gastroenterology 138:1418-28. 2010
    The adenomatous polyposis cell (APC) tumor suppressor is a multifunctional protein involved in cell migration, proliferation, differentiation, and apoptosis...
  38. ncbi Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
    I Nishisho
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Science 253:665-9. 1991
    ..Two genes on 5q21 that are tightly linked to FAP (MCC and APC) were found to be somatically altered in tumors from sporadic colorectal cancer patients...
  39. ncbi The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell
    M Hart
    Onyx Pharmaceuticals 3031 Research Drive Richmond California 94806 USA
    Curr Biol 9:207-10. 1999
    ..In contrast, beta-TrCP2 did not associate with beta-catenin. We conclude that beta-TrCP is a component of an E3 ubiquitin ligase that is responsible for the targeted degradation of phosphorylated beta-catenin...
  40. ncbi Crystal structure of a beta-catenin/Tcf complex
    T A Graham
    Department of Biological Structure University of Washington 98195, Seattle, WA, USA
    Cell 103:885-96. 2000
    ..three sites in beta-catenin that are critical for binding the Tcf3-CBD and are differentially involved in binding APC, cadherin, and Axin. The structural and mutagenesis data reveal a potential target for molecular drug design studies...
  41. ncbi Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration
    Takashi Watanabe
    Department of Cell Pharmacology, Nagoya University, Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466 8550, Japan
    Dev Cell 7:871-83. 2004
    ..Adenomatous polyposis coli (APC) is also thought to play a pivotal role in polarized cell migration...
  42. doi Multiple rare nonsynonymous variants in the adenomatous polyposis coli gene predispose to colorectal adenomas
    Duncan Azzopardi
    Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom
    Cancer Res 68:358-63. 2008
    ..We have studied this hypothesis by sequencing the adenomatous polyposis coli (APC) gene in 691 unrelated North American patients with CRAs and 969 matched healthy controls...
  43. ncbi AMER1 regulates the distribution of the tumor suppressor APC between microtubules and the plasma membrane
    Annette Grohmann
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nuremberg, Glückstr 6, 91054 Erlangen, Germany
    J Cell Sci 120:3738-47. 2007
    b>APC is a multifunctional tumor suppressor protein that negatively controls Wnt signaling, but also regulates cell adhesion and migration by interacting with the plasma membrane and the microtubule cytoskeleton...
  44. ncbi Association of the APC tumor suppressor protein with catenins
    L K Su
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 262:1734-7. 1993
    Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been well characterized, little is known about the function of the APC gene product...
  45. pmc Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm
    K L Neufeld
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 97:12085-90. 2000
    Mutational inactivation of the adenomatous polyposis coli (APC) tumor suppressor initiates most hereditary and sporadic colon carcinomas...
  46. ncbi Wnt signalling and the actin cytoskeleton
    T Akiyama
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Oncogene 25:7538-44. 2006
    The tumour suppressor adenomatous polyposis coli (APC) is mutated in sporadic and familial colorectal tumours. APC binds to beta-catenin, a key component of the Wnt signalling pathway, and induces its degradation...
  47. pmc Novel association of APC with intermediate filaments identified using a new versatile APC antibody
    Yang Wang
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS, USA
    BMC Cell Biol 10:75. 2009
    As a key player in suppression of colon tumorigenesis, Adenomatous Polyposis Coli (APC) has been widely studied to determine its cellular functions...
  48. pmc A common role for various human truncated adenomatous polyposis coli isoforms in the control of beta-catenin activity and cell proliferation
    Shree Harsha Vijaya Chandra
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nurnberg, Glückstrasse, Erlangen, Germany
    PLoS ONE 7:e34479. 2012
    The tumour suppressor gene adenomatous polyposis coli (APC) is mutated in most colorectal cancer cases, leading to the synthesis of truncated APC products and the stabilization of β-catenin...
  49. ncbi Regulation and function of the interaction between the APC tumour suppressor protein and EB1
    J M Askham
    Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James s University Hospital, Leeds LS9 7TF, UK
    Oncogene 19:1950-8. 2000
    The interaction between the adenomatous polyposis coli (APC) tumour suppressor and the microtubule-associated protein EB1 was examined...
  50. doi APC or MUTYH mutations account for the majority of clinically well-characterized families with FAP and AFAP phenotype and patients with more than 30 adenomas
    B Filipe
    Centro de Investigacao de Patobiologia Molecular CIPM, Patológica Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE IPOLFG, EPE, 1099 023 Lisboa, Portugal
    Clin Genet 76:242-55. 2009
    ..Overall, APC or MUTYH mutations were detected in 42/48 (88%), 14/20 (70%) and 10/38 (26%) of FAP, AFAP and MCRA patients, ..
  51. pmc Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein
    T Kiyono
    Laboratory of Viral Oncology, Aichi Cancer Center, Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464, Japan
    Proc Natl Acad Sci U S A 94:11612-6. 1997
    ..These results suggest an intriguing possibility that interaction between the E6 protein and hDLG or other PDZ domain-containing proteins could be an underlying mechanism in the development of HPV-associated cancers...
  52. pmc Structural basis of the Axin-adenomatous polyposis coli interaction
    K E Spink
    Department of Structural Biology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, CA 94305, USA
    EMBO J 19:2270-9. 2000
    Axin and the adenomatous polyposis coli (APC) tumor suppressor protein are components of the Wnt/Wingless growth factor signaling pathway...
  53. ncbi The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF
    Fumihiko Hamada
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Dev Cell 7:677-85. 2004
    Adenomatous polyposis coli (APC) is an important tumor suppressor in the colon...
  54. doi Hypermethylation of APC promoter 1A is associated with moderate activation of Wnt signalling pathway in a subset of colorectal serrated adenomas
    Xiangsheng Fu
    Institute for Digestive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China
    Histopathology 55:554-63. 2009
    ..The aim of this study was to determine whether Wnt signalling plays a role in the pathogenesis of SAs, and to clarify the mechanism of Wnt signalling activation in SAs...
  55. doi Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability
    Cristina Albuquerque
    Centro de Investigacao de Patobiologia Molecular CIPM, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisboa, Portugal
    Genes Chromosomes Cancer 49:746-59. 2010
    ..We have previously shown that in familial adenomatous polyposis, APC somatic mutations are selected to provide the "just-right" level of WNT signaling for tumor formation...
  56. doi Brain metastases exhibit gross deletions of the APC gene
    Nives Pecina-Slaus
    Laboratory of Neurooncology, Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Salata 12, 10000 Zagreb, Croatia
    Brain Tumor Pathol 28:223-8. 2011
    ..In the present study, the adenomatous polyposis coli (APC) gene was analyzed in a set of human brain metastases...
  57. ncbi Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization
    M Nakamura
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Curr Biol 11:1062-7. 2001
    Human EB1 was originally cloned as a protein that interacts with the COOH terminus of adenomatous polyposis coli (APC). Interestingly, this interaction is often disrupted in colon cancer, due to mutations in APC...
  58. doi Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68
    Ella Czarina Morishita
    RIKEN Systems and Structural Biology Center, 1 7 22 Suehiro cho, Tsurumi, Yokohama 230 0045, Japan
    Structure 19:1496-508. 2011
    Adenomatous polyposis coli (APC) is a tumor suppressor protein commonly mutated in colorectal tumors. APC plays important roles in Wnt signaling and other cellular processes...
  59. ncbi A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor
    J Couture
    Department of Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Genet 57:205-12. 2000
    ..phenotypes have been associated with different sites of germline mutations in the adenomatous polyposis coli gene (APC gene)...
  60. pmc Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein
    F Zhang
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Building 555, Room 5263, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 97:12577-82. 2000
    Mutation of the adenomatous polyposis coli (APC) gene is an early step in the development of colorectal carcinomas. APC protein is located in both the cytoplasm and the nucleus...
  61. ncbi Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation
    J Zumbrunn
    School of Life Sciences, University of Dundee, Dundee, Scotland
    Curr Biol 11:44-9. 2001
    Truncation mutations in the adenomatous polyposis coli protein (APC) are responsible for familial polyposis, a form of inherited colon cancer...
  62. doi Epigenetic alterations of CDH1 and APC genes: relationship with activation of Wnt/beta-catenin pathway in invasive ductal carcinoma of breast
    Chandra P Prasad
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Life Sci 83:318-25. 2008
    ..Herein, we analyzed promoter methylation status of CDH1 and Adenomatous polyposis coli (APC) genes in 50 IDCs and correlated with expression of E-cadherin (E-CD) and APC proteins and with activation of ..
  63. pmc Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?
    David P Minde
    Cellular Protein Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584CH Utrecht, The Netherlands
    Mol Cancer 10:101. 2011
    Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene strongly predispose to development of gastro-intestinal tumors...
  64. ncbi Promoter hypermethylation as an independent prognostic factor for relapse in patients with prostate cancer following radical prostatectomy
    Eli Rosenbaum
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, John Hopkins School of Medicine, Baltimore, MD 21205 2196, USA
    Clin Cancer Res 11:8321-5. 2005
    To analyze the prognostic significance of six epigenetic biomarkers (APC, Cyclin D2, GSTP1, TIG1, Rassf1A, and RARbeta2 promoter hypermethylation) in a homogeneous group of prostate cancer patients, following radical prostatectomy alone.
  65. ncbi The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, California 94806
    J Biol Chem 270:5549-55. 1995
    The tumor suppressor APC protein associates with the cadherin-binding proteins alpha- and beta-catenin...
  66. ncbi EB/RP gene family encodes tubulin binding proteins
    J P Juwana
    Medical Department I, Saarland University, Homburg, Germany
    Int J Cancer 81:275-84. 1999
    Mutations in the adenomatous polyposis coli (APC) gene are linked to the dysplastic transformation of colorectal polyps and represent an early step in the development of colorectal tumors...
  67. ncbi GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin
    S Ikeda
    Department of Biochemistry, Hiroshima University School of Medicine, Japan
    Oncogene 19:537-45. 2000
    Axin forms a complex with adenomatous polyposis coli gene product (APC), glycogen synthase kinase-3beta (GSK-3beta), and beta-catenin through different binding sites and downregulates beta-catenin...
  68. pmc Clinical characterization and the mutation spectrum in Swedish adenomatous polyposis families
    Gunilla Kanter-Smoler
    Department of Molecular and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    BMC Med 6:10. 2008
    The dominantly inherited condition familial adenomatous polyposis (FAP) is caused by germline mutations in the APC gene. Finding the causative mutations has great implications for the families...
  69. doi Common variants in human CRC genes as low-risk alleles
    Simone Picelli
    Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
    Eur J Cancer 46:1041-8. 2010
    ..05-1.72), respectively (under the dominant model); while 2 SNPs, rs1800932:A>G (MSH6 P92P) and rs459552:T>A (APC D1822V) seemed to confer a protective effect. The latter, in particular showed an odds ratio of 0.76 (CI=0.60-0...
  70. pmc The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase
    G H Baeg
    Department of Oncogene Research, Osaka University, Japan
    EMBO J 14:5618-25. 1995
    The APC gene is mutated in familial adenomatous polyposis (FAP) as well as in sporadic colorectal tumours. The product of the APC gene is a 300 kDa cytoplasmic protein associated with the adherence junction protein catenin...
  71. ncbi Genotype and phenotype of patients with both familial adenomatous polyposis and thyroid carcinoma
    Brindusa Truta
    University California San Francisco, Department of Medicine, Comprehensive Cancer Center, San Francisco, California, USA
    Fam Cancer 2:95-9. 2003
    ..3%) unrelated patients with FAP associated thyroid cancers were identified. Adenomatous polyposis coli (APC) gene testing was performed in 14 of the 16 cases...
  72. pmc Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC
    Rebecca A Green
    Section of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USA
    J Cell Biol 163:949-61. 2003
    ..The mitotic abnormalities associated with CIN+ tumor cells correlated with status of adenomatous polyposis coli (APC)...
  73. pmc Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation
    N J H Sturt
    Polyposis Registry, St Mark s Hospital, Harrow, Middlesex HA1 3UJ, UK
    Gut 53:1832-6. 2004
    ..FAP results from germline adenomatous polyposis coli (APC) gene mutations and desmoids arise following biallelic APC mutation, with one change usually occurring distal to ..
  74. ncbi Familial adenomatous polyposis (FAP): genotype correlation to FAP phenotype with osteomas and sebaceous cysts
    Marie Luise Bisgaard
    Institute of Medical Biochemistry and Genetics, Department G, Copenhagen University, Panum Institute 24 4, Copenhagen N, Denmark
    Am J Med Genet A 140:200-4. 2006
    ..This disorder was regarded as a separate disease until the identification of the APC gene when it was recognized that mutations in the APC gene were the underlying cause of both Gardner syndrome and ..
  75. pmc Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability
    Karin Kroboth
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Biol Cell 18:910-8. 2007
    Most sporadic colorectal tumors carry truncation mutations in the adenomatous polyposis coli (APC) gene. The APC protein is involved in many processes that govern gut tissue...
  76. ncbi Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis
    M Nielsen
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Clin Genet 71:427-33. 2007
    ..We aimed to assess the presence of germline mutations in the MUTYH and adenomatous polyposis coli (APC) genes in AFAP families and to compare the clinical features between the two causative genes...
  77. doi APC promoter hypermethylation is an early event in endometrial tumorigenesis
    Atanas Ignatov
    Department of Obstetrics and Gynecology, Otto von Guericke University, Magdeburg, Germany
    Cancer Sci 101:321-7. 2010
    The aim of the current study was to investigate the role of promoter methylation of adenomatous polyposis coli (APC) and epithelial cadherin (E-cadherin) genes in endometrial tumorigenesis...
  78. ncbi Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer
    Y Miki
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Cancer Res 52:643-5. 1992
    The APC gene is responsible for familial adenomatous polyposis and is considered to be a tumor suppressor gene associated with development of sporadic colorectal tumors...
  79. ncbi APC binds to the novel protein EB1
    L K Su
    Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA
    Cancer Res 55:2972-7. 1995
    Mutations of the APC gene play a critical role in both sporadic and familial forms of colorectal cancer. The vast majority of these mutations result in the loss of the carboxyl terminus of the protein...
  80. ncbi Association of the APC gene product with beta-catenin
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, CA 94806
    Science 262:1731-4. 1993
    Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and gastric tumors...
  81. ncbi Identification of an alternative 5' untranslated region of the adenomatous polyposis coli gene
    S Lambertz
    Institut für Humangenetik der Universität, Erlangen, Germany
    Hum Genet 90:650-2. 1993
    ..expressed in human fetal brain, have been isolated that specify the 5' end of the adenomatous polyposis coli (APC) gene...
  82. pmc The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history
    I M Frayling
    Colorectal Cancer Unit, Imperial Cancer Research Fund, St Mark s and Northwick Park Hospitals National Health Service Trust, Harrow, HA1 3UJ, United Kingdom
    Proc Natl Acad Sci U S A 95:10722-7. 1998
    ..to hundreds or thousands of colorectal adenomas and carcinoma and that results from truncating mutations in the APC gene...
  83. ncbi The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis
    H Lamlum
    Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, 44, Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Med 5:1071-5. 1999
    b>APC is often cited as a prime example of a tumor suppressor gene. Truncating germline and somatic mutations (or, infrequently, allelic loss) occur in tumors in FAP (familial adenomatous polyposis)...
  84. ncbi Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor
    C L Day
    Department of Molecular and Cell Biology, University of California, 229 Stanley Hall 3206, Berkeley, CA, 94720 3206, USA
    J Mol Biol 301:147-56. 2000
    ..domains for a wide variety of proteins, including the medically important oligomeric tumor suppressor protein, APC. Mutations in the APC gene are associated with an inherited susceptibility to colon cancer and with approximately ..
  85. ncbi Genomic rearrangements of the APC tumor-suppressor gene in familial adenomatous polyposis
    L K Su
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Hum Genet 106:101-7. 2000
    Germline mutations of the adenomatous polyposis coli (APC) tumor-suppressor gene result in the hereditary colorectal cancer syndrome familial adenomatous polyposis (FAP)...
  86. pmc Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells
    A Reinacher-Schick
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Cell Biol 152:491-502. 2001
    The adenomatous polyposis coli (APC) protein is implicated in the majority of hereditary and sporadic colon cancers...
  87. ncbi The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin
    A H Huber
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 105:391-402. 2001
    ..the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. We have determined the crystal structures of both unphosphorylated and phosphorylated E-cadherin cytoplasmic ..
  88. ncbi Polymorphisms and colorectal tumor risk
    R S Houlston
    Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK
    Gastroenterology 121:282-301. 2001
    ..To assess the evidence that any of these confers a risk, a systematic review and meta-analysis of published studies was undertaken...
  89. pmc Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex
    K Eklof Spink
    Departments of Structural Biology and of Molecular and Cellular Physiology, Stanford University School of Medicine, 299 Campus Dr West Stanford, CA 94305, USA
    EMBO J 20:6203-12. 2001
    The adenomatous polyposis coli (APC) tumor suppressor protein plays a critical role in regulating cellular levels of the oncogene product beta-catenin. APC binds to beta-catenin through a series of homologous 15 and 20 amino acid repeats...
  90. ncbi Identification of a link between the tumour suppressor APC and the kinesin superfamily
    Takeshi Jimbo
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Cell Biol 4:323-7. 2002
    The tumour suppressor gene adenomatous polyposis coli (APC) is mutated in sporadic and familial colorectal tumours...
  91. ncbi Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    Chunming Liu
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 108:837-47. 2002
    ..by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and adnomatous polyposis coli (APC)...
  92. pmc Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway
    Sharon Amit
    The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Genes Dev 16:1066-76. 2002
    ..Normally, cytoplasmic beta-catenin associates with APC and axin and is continuously phosphorylated by GSK-3beta, marking it for proteasomal degradation...
  93. ncbi Novel mutations of the APC gene in familial adenomatous polyposis in Greek patients
    M Mihalatos
    Molecular Biology Research Center, HYGEIA Antonis Papayiannis, Athens, Greece
    Cancer Genet Cytogenet 141:65-70. 2003
    ..Approximately 80% of patients with FAP harbor truncating germline mutations in the adenomatous polyposis coli (APC) tumor suppressor gene. We tested 24 members of six Greek families...
  94. ncbi Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC protein
    Lara Tickenbrock
    Max Planck Institut fur molekulare Physiologie, Otto Hahn Strasse 11, D 44227 Dortmund, Germany
    J Mol Biol 327:359-67. 2003
    The tumour suppressor protein adenomatous polyposis coli (APC) regulates the level and the intracellular localisation of the proto-oncoprotein beta-catenin...
  95. ncbi Characterization of functional domains of human EB1 family proteins
    Wen Bu
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 278:49721-31. 2003
    ..which include EB1, EBF3, and RP1, also associate with the tumor suppressor protein adenomatous polyposis coli (APC) and p150glued, a component of the dynactin complex...
  96. ncbi Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion
    Maree C Faux
    Ludwig Institute for Cancer Research, Parkville, Victoria 3050, Australia
    J Cell Sci 117:427-39. 2004
    The APC tumour suppressor gene is mutated in most colon cancers...
  97. ncbi Familial adenomatous polyposis: aberrant splicing due to missense or silent mutations in the APC gene
    Stefan Aretz
    Institute of Human Genetics, University Hospital of Bonn, Bonn, Germany
    Hum Mutat 24:370-80. 2004
    Familial adenomatous polyposis (FAP) is caused by germline mutations in the tumor suppressor gene APC. To date, the relevance of rare exonic single-base substitutions at nucleotide positions close to splice sites that are predicted to ..
  98. ncbi Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability
    Anthony Tighe
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    J Cell Sci 117:6339-53. 2004
    ..cause chromosome instability remain undefined, mouse ES cells harbouring homozygous adenomatous polyposis coli (APC) mutations are frequently tetraploid...
  99. pmc Rare mutations predisposing to familial adenomatous polyposis in Greek FAP patients
    Markos Mihalatos
    Molecular Biology Research Center HYGEIA Antonis Papayiannist, Athens, Greece
    BMC Cancer 5:40. 2005
    Familial Adenomatous Polyposis (FAP) is caused by germline mutations in the APC (Adenomatous Polyposis Coli) gene...
  100. ncbi Genetic analyses in consecutive israeli jewish colorectal cancer patients
    Herma H Fidder
    Institute of Gastroenterology and the Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Am J Gastroenterol 100:1376-80. 2005
    Two APC germline mutations, E1317Q and I1307K, have been linked to colorectal cancer (CRC) risk. Whereas the I1307K variant is almost exclusively encountered in (Ashkenazi) Jews, E1317Q is not restricted to certain ethnic populations...
  101. ncbi Colorectal polyps in carriers of the APC I1307K polymorphism
    Gad Rennert
    Department of Community Medicine and Epidemiology, CHS National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
    Dis Colon Rectum 48:2317-21. 2005
    The probability of colorectal cancer is moderately increased among carriers of the APC I1307K polymorphism. However, it is not known if endoscopic surveillance of this high-risk group is warranted...

Research Grants97

  1. Ontogeny and function of zebrafish antigen presenting cells
    David Traver; Fiscal Year: 2011
    ..With the ability to specifically identify each of the APC subsets, we will utilize this information to determine the cellular architecture of secondary lymphoid organs under ..
  2. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
    ..These professional antigen presenting cells (APC) also endocytose HIV-1 and present viral peptides to responding T cells in association with HLA class I and class ..
  3. Klaus F Ley; Fiscal Year: 2016
    ..CXCL4, the product of the Pf4 gene, is pro-atherogenic and drastically alters macrophage phenotype. To investigate APC functions, foam cell formation, antigen presentation and the impact of Pf4 on these processes, we propose to ..
  4. Astrid E Cardona; Fiscal Year: 2016
    ..The hypothesis behind the proposed research is that CX3CR1/CX3CL1 regulates antigen presenting cell (APC) effector functions influencing the development of pathogenic T cells during experimental autoimmune ..
  5. CYTOTOXIC T CELL RESPONSES TO HHV-8
    Charles R Rinaldo; Fiscal Year: 2013
    ..of KS, and that this is linked to interactions with HHV-8 infected, professional antigen presenting cells (APC), particularly blood and tissue dendritic cells (DC) and B cells...
  6. David Q Shih; Fiscal Year: 2016
    ..Several studies have shown that TNFSF15 is expressed by antigen presenting cells (APC) and determines the severity of chronic gut inflammation by enhancing Th1, Th17 and Th2 responses...
  7. Haochu Huang; Fiscal Year: 2015
    ..Although the question of which APC is responsible for negative selection has been investigated extensively, the role of thymic B cells as APCs in ..
  8. Pavan Reddy; Fiscal Year: 2016
    ..published during the current funding cycle from our lab, and others, demonstrate that any individual hematopoietic APC subset is dispensable for induction of GVHD, but are collectively, critical for GVL responses...
  9. Shannon J Turley; Fiscal Year: 2016
    ..The team emphasizes direct investigation of APC - T cell interactions in patients with autoimmune diseases, in particular multiple sclerosis (MS), and integrates ..
  10. UBIQUITIN-DEPENDENT REGULATION OF IMMUNE ACTIVATION
    Lonnie P Lybarger; Fiscal Year: 2010
    ..Antigen presenting cells (APC), including dendritic cells, represent key regulators of immune activation...
  11. Yan Shi; Fiscal Year: 2016
    ..Binding of particulate antigens by antigen presenting cells (APC) is a critical step in immune activation...
  12. Imaging and Function of the Immunological Synapse
    David C Parker; Fiscal Year: 2012
    ..lymphocytes recognize antigen as small peptides bound to MHC molecules on the surface of antigen presenting cells (APC)...
  13. Robert M Prins; Fiscal Year: 2014
    ..Cytotoxic T Lymphocytes (CTL)-effector cells for immunotherapy 2. Dendritic Cells (DC)-antigen presenting cells (APC) used to induce CTL effectors in vitro 3...
  14. THORSTEN ROMAN MEMPEL; Fiscal Year: 2014
    ..It is becoming apparent that local crosstalk between Treg and myeloid antigen-presenting cells (APC) in the tumor microenvironment is critical for their immunosuppressive function on anti-tumor effector cells, most ..
  15. JESSE PAUL GOFF; Fiscal Year: 2016
    ..Mutations in the adenomatous polyposis coli (Apc) gene, originally linked to familial forms of colon cancer, have also been identified in the preponderance of human ..
  16. TUMOR SUPPRESSION BY THE APC GENE
    Joanna Groden; Fiscal Year: 1999
    ..One such genetic disorder is adenomatous polyposis coli or APC. We mapped and then isolated the APC gene by positional cloning from a region of chromosome 5q...
  17. Arthur A Vandenbark; Fiscal Year: 2014
    ..in a peptide-specific manner, new data showing rapid antigen non-specific RTL binding to antigen-presenting cells (APC), including macrophages, dendritic cells (DC) and B cells, strongly suggest alternative tolerogenic pathways...
  18. GENES FROM THE FAP LOCUS
    KENNETH KINZLER; Fiscal Year: 2001
    ..from the investigator's abstract) The majority of colorectal cancers are associated with somatic mutations of the APC tumor suppressor gene...
  19. Effects of apoptotic epithelial cell engulfment on mucosal inflammation
    Peter B Ernst; Fiscal Year: 2010
    ..Antigen presenting cells (APC), including macrophages and dendritic cells, can remove bacteria, cellular debris and dead cells through ..
  20. Yang D Dai; Fiscal Year: 2015
    ..a novel hypothesis that EXO may act as a unique type of endogenous adjuvant and antigen carrier that can condition APC to alter the processing/presenting of the autoantigens and thus, to activate the autoreactive T cells...
  21. Photo-inactivation of Leishmania for safe and effective delivery of surrogate vac
    Kwang Poo Chang; Fiscal Year: 2013
    ..not only do Leishmania resist humoral lytic factors and parasitize exclusively the antigen-presenting cells (APC), i. e. macrophages/dendritic cells, but also live in their phagolysosomes - a desirable site for vaccine delivery...
  22. Dendritic Cells in the Breaking of Peripheral Tolerance in Type 1 Diabetes
    JONATHAN DAVID KATZ; Fiscal Year: 2012
    ..participants, their activation and functional maturation are controlled by the innate antigen presenting cells (APC) which acquire, process and present pancreatic beta cell antigen in a manner that breaks normal peripheral T cell ..
  23. Role of PGE2 in CNS and peripheral autoimmune disorders
    Doina Ganea; Fiscal Year: 2010
    ..of the molecular and cellular factors involved in the generation, activation, and maintenance of IL-23-producing APC and of pathogenic ThlL-17 will have a significant impact on our understanding and intervention in autoimmune ..
  24. Anna Karolina Palucka; Fiscal Year: 2015
    ..surveillance that include epithelial cells as well as highly specialized professional antigen presenting cells (APC) distributed throughout the conducting airways and the lung parenchyma...
  25. Ulrich H von Andrian; Fiscal Year: 2015
    ..immune responses require contact-dependent information exchange between T cells and antigen (Ag)-presenting cells (APC)...
  26. Duke Geem; Fiscal Year: 2014
    ..However, little is known regarding intestinal APC-mediated T cell differentiation...
  27. Mechanisms of HIV-associated Disruption of Intestinal Homeostasis
    Cara C Wilson; Fiscal Year: 2013
    ..Intestinal dendritic cells (IDCs), potent antigen presenting cells (APC) that bridge innate and adaptive immunity, are able to sample luminal bacteria and likely play a key role in ..
  28. Alpha-galactosycleramide as a mucosal adjuvant for HIV antigens
    JAGANNADHA K SASTRY; Fiscal Year: 2010
    ..the use of suitable adjuvants that could directly potentiate the effector T cells and the antigen-presenting cells (APC), such as the dendritic cells (DC), and/or mobilize the innate immune responses...
  29. Mechanisms of Chronic Nod2-mediated Effects in Human Macrophages
    Clara Abraham; Fiscal Year: 2012
    ..NOD2, either alone or in combination with other bacterial receptors, peripherally-derived antigen presenting cells (APC) secrete proinflammatory cytokines...
  30. Mechanisms of apoptotic cell clearance in the human stomach
    Peter B Ernst; Fiscal Year: 2013
    ..Antigen presenting cells (APC) including macrophages and dendritic cells can remove bacteria, cellular debris and dead cells through phagocytosis ..
  31. Dmitry I Gabrilovich; Fiscal Year: 2014
    Dendritic cells (DC) are the most potent antigen presenting cells (APC) and play a critical role in generation of immune responses against bacterial and viral pathogens, tumor antigens, and are involved in the development of autoimmune ..
  32. Mechanisms of Multiple Sclerosis Tissue Pathology
    Claudia F Lucchinetti; Fiscal Year: 2012
    ..We will characterize T cells and APCs in the SAS and define the nature of T cell-APC contacts. Our preliminary data demonstrates myelin laden macrophages in both SAS and CDM lesions...
  33. Richard S Blumberg; Fiscal Year: 2016
    ..The current research proposal addresses the unanswered question of how FcRn [in antigen presenting cells (APC)] contributes to ho- meostatic and pathogenic mucosal immune responses...
  34. Immunization Strategies for Autologous HIV Immunotherapy
    Louis D Falo; Fiscal Year: 2012
    ..Besides being the most potent antigen-presenting cells (APC), they determine the nature and magnitude of immune responses and provide an essential link between innate and ..
  35. Targeting Dendritic Cell Subsets in Human Vagina to Elicit Local Immunity
    SangKon Oh; Fiscal Year: 2010
    ..STDs: 1) The subsets of APCs that can elicit optimal quantity and quality of mucosal immunity in the vagina, 2) APC subset-specific surface receptors and activators for: a) delivering vaccines to appropriate subsets of APCs and b) ..
  36. Dissecting Dendritic Cell Function in Autoimmune Diabetes
    JONATHAN DAVID KATZ; Fiscal Year: 2013
    ..however, that these T cells receive critical pro- and anti-proliferative signals from antigen presenting cells (APC) such as dendritic cells (DC), and that these T cell-APC interactions dramatically influence the effector T cell ..
  37. Mechanisms of increased susceptibility to TB in HIV-Infected individuals
    David H Canaday; Fiscal Year: 2013
    ..of MTB is through cell-mediated immunity primarily involving CD4+ and CD8+ T cells and antigen presenting cells (APC) including both macrophages and dendritic cells (DC). HIV productively infects three of these cell types...
  38. Mechanisms of Effector CD4 Cell Tolerization
    Adam Adler; Fiscal Year: 2009
    ..parenchymal self-antigen are rendered non-responsive/anergic by bone marrow-derived antigen presenting cells (APC) that acquire and indirectly present cognate parenchymal self-antigen...
  39. Richard D Cummings; Fiscal Year: 2016
    ..of inflammatory responses is mainly mediated via the innate immune system through antigen presenting cells (APC), including dendritic cells (DC) and macrophages (M[unreadable])...
  40. Paolo Serafini; Fiscal Year: 2014
    ..novel nanostructure gene-based vaccine delivery that efficiently and specifically targets antigen-presenting cells (APC)...
  41. Mary L Disis; Fiscal Year: 2014
    ..inflammatory cytokines, modulating the microenvironment to enhance the function of local antigen presenting cells (APC). The resultant increased processing of endogenous tumor cells results in epitope spreading...
  42. KATHERINE BREMPELIS; Fiscal Year: 2014
    ..I propose to first study the effects of chronic alcohol exposure on the cell biology of the liver APC populations by using multiple methods such as microscopy, western blotting, qRT-PCR, and in vitro cell assays to ..
  43. Nathan E Welty; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Dendritic cells (DC) are specialized antigen presenting cells (APC) that are critical for initiating and regulating adaptive immune responses...
  44. Timothy J Sellati; Fiscal Year: 2016
    ....
  45. Young J Kim; Fiscal Year: 2016
    ..Magnetovaccination has a high translation potential to quantify APC trafficking...
  46. Initiation and maintenance of adaptive immunity to Mycobacterium tuberculosis
    TYLER DALLAS BOLD; Fiscal Year: 2010
    ..I will also determine the contribution of individual APC subsets and the relative contribution of M...
  47. Vijay K Kuchroo; Fiscal Year: 2016
    ..However, numerous studies have pointed to defects in antigen- presenting cells (APC) in individuals with T1D...
  48. ALEX YEE CHEN HUANG; Fiscal Year: 2015
    ..of anti-tumor CD8+ memory T cells, but also will provide direct in vivo evidence for the roles which the host APC and tumors play in priming CD8+ T cells against tumor-associated antigen...
  49. EMIL RAPHAEL UNANUE; Fiscal Year: 2014
    ..e., it has an "adjuvant" effect), inducing cytokine production and cell activation on the antigen presenting cells (APC)...
  50. Signal Initiation from the T-cell Antigen Receptor by Mechanical Force
    TERRI FINKEL; Fiscal Year: 2009
    ..Considering the sufficiency of these three components in TCR triggering, the dynamic nature of T cell-APC interaction, and the constant mechanical stresses on pMHC-TCR interaction, we propose a new model for TCR ..
  51. MHC association in autoimmune arthritis
    Elizabeth D Mellins; Fiscal Year: 2010
    ..affinity affect the stability, longevity, and abundance of class II molecules in model antigen presenting cells (APC) and can modulate antigen presentation...
  52. XIAOSONG JOY JIANG; Fiscal Year: 2016
    ..In addition, recent data indicate that HSC behave as antigen presenting cells (APC). However, their role in the regulation of hepatic immune responses during fibrogenesis is not well understood...
  53. Lonnie D Shea; Fiscal Year: 2016
    ..their distribution, and can be modified with functional groups to promote internalization, target specific APC populations or receptors, and can release bioactive proteins to enhance the tolerogenic response...
  54. N-3 PUFAs and antigen presenting cells
    Saame R Shaikh; Fiscal Year: 2010
    ..complex (MHC) class I antigen presentation pathway by modifying the biophysical organization of the APC plasma membrane...
  55. Pathways of Antigen Presentation to CD8 T Cells In Vivo
    Christopher C Norbury; Fiscal Year: 2013
    ..effectors cells only after recognition of peptide-MHC Class I complexes on the surface of antigen presenting cells (APC). The peptides recognized as part of the peptide-MHC complex can be generated from two spatially distinct sources...
  56. Defining the intrahepatic immune response to hepatitis C virus
    Arash Grakoui; Fiscal Year: 2013
    ..Hepatic stellate cells (HSC) are a novel population of intrahepatic APC that undergo dramatic phenotypic and functional changes in response to liver injury or infection...
  57. STUDIES OF ANTIGEN STIMULATION
    Emil Unanue; Fiscal Year: 2009
    ..investigated how the model protein antigen hen egg-white lysozyme (HEL) was processed by antigen presenting cells (APC);and established the chemical basis for the processing, selection by, and binding of, its various peptides to I-Ak ..
  58. DANIEL S MUCIDA; Fiscal Year: 2014
    ..The investigation of the dynamics of APC behavior in the two regions at steady state and under intestinal infection conditions will be followed by the ..
  59. Mechanisms of Tolerance to Renal Maternal Microchimerism
    ANNE MARGUERITE STEVENS; Fiscal Year: 2011
    ..Specific Aim #3 will investigate indirect T lymphocyte alloreactivity to maternal antigens presented by host APC in SLE-N patients compared with controls using apoptotic or necrotic maternal cells as sources of maternal antigens...
  60. Eduardo M Sotomayor; Fiscal Year: 2015
    ..of this grant, we have identified several signaling pathways that, by regulating the inflammatory status of the APC are critical in the decision leading to T-cell activation versus T-cell tolerance...
  61. David V Serreze; Fiscal Year: 2016
    ..NOD mice also undergo negative selection if forced to mature in the presence of engrafted antigen presenting cells (APC) expressing some non-H2g7 MHC haplotypes. Specific aim 2 will determine if diabetogenic HLA-A2...
  62. Yoji Shimizu; Fiscal Year: 2014
    ..TCR signaling rapidly increases the functional activity of the LFA-1 integrin, thus enhancing T-APC contacts required for the transmission of the full array of signals required for optimal T cell proliferation and ..
  63. Francis M Giardiello; Fiscal Year: 2015
    Familial adenomatous polyposis coli (FAP) is an autosomal dominant disorder due to germline mutation of the APC gene and characterized by the formation of hundreds of colorectal adenomatous polyps in young adults...
  64. Timing of Rectal Cancer Response to Chemoradiation
    Julio Garcia Aguilar; Fiscal Year: 2009
    ..cells microdissected from pre-chemoradiation biopsy specimens will be tested for mutations in the p53, k-ras and APC genes, BAT26 deletions, and p16 promoter methylation...
  65. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..will be recruited to contribute in a substantial way to the progress of sub-aims of my parent New Innovator (DP2) Award; the DP2's main specific aims are to develop novel microscopes (Aim 1) and analytical tools (Aim 2) to ..
  66. Role of Kruppel-Like Factor 4 in Wnt and Notch Signaling in the Intestinal Tract
    Amr Ghaleb; Fiscal Year: 2010
    ..Studies have shown that somatic or germ-line mutations in adenomatous polyposis coli (APC), p53, and genes involved in DMA mismatch repair such as MLH1 and MSH2, and oncogenic activation of KRAS and BRAF ..
  67. Vincent W Yang; Fiscal Year: 2016
    ..Thus, somatic or germline inactivation of TSGs such as adenomatous polyposis coli (APC), p53 and several genes involved in DNA mismatch repair;and oncogenic activation of KRAS, BRAF and ?-catenin have ..
  68. Use of Closely Related Inbred Strains to Identify Modifier Loci of Tumorigenesis
    Linda D Siracusa; Fiscal Year: 2013
    ..The adenomatous polyposis coli (APC) tumor suppressor gene is mutated in Familial Adenomatous Polyposis (FAP), an inherited disorder that predisposes ..
  69. William C Hahn; Fiscal Year: 2014
    ..Inheritance of a germline mutation in APC drives the colon cancer syndrome, Familial Adenomatous Polyposis (FAP), and aberrant activation of the [unreadable]-..
  70. Sapna Syngal; Fiscal Year: 2016
    ..JAMA 2012) which predicts the likelihood of an individual carrying a germline mutation in the APC and MYH genes, related to Familial Adenomatous Polyposis and MYH-Associated Polyposis...
  71. JAMES PETER ROBINSON; Fiscal Year: 2014
    ..FAP is caused by germline mutations in the Adenomatous Polyposis Coli (APC) gene. APC mutations are also found in sporadic colorectal adenomas and 85% of colon cancers carry APC mutations...
  72. CDX2 TUMOR SUPPRESSOR PATHWAY DEFECTS IN COLON CANCER
    Eric Fearon; Fiscal Year: 2009
    ..Recent studies in CRC show that whereas the APC (adenomatous polyposis coli), KRAS, and p53 genes are each frequently altered, many other genes are each mutated in ..
  73. Mouse Models of Sporadic Colorectal Cancer
    MELINDA ANGUS-HILL; Fiscal Year: 2012
    ..The majority of colon cancers are characterized by genetic mutations in adenomatous polyposis coli (APC) or (-catenin, two key components of the Wnt signaling pathway...
  74. Anna Birukova; Fiscal Year: 2016
    ..We hypothesize that MT-associated adaptor protein APC (adenomatous polyposis coli) can bind and deliver a novel Rac-specific guanine nucleotide exchange factor Asef ..
  75. Uterine-specific genetic modification and lymphangioleiomyomatosis
    JOSE M TEIXEIRA; Fiscal Year: 2012
    ..constitutively activating [unreadable]-catenin or by expressing a truncated allele of adenomatous polyposis coli (APC) and we have shown preliminary evidence that the leiomyomas develop as a result of vascular hemorrhaging and ..
  76. Modifiers of Intestinal Tumor Progression
    Linda D Siracusa; Fiscal Year: 2012
    ..The adenomatous polyposis coli (APC) tumor suppressor gene is mutated in Familial Adenomatous Polyposis (FAP), a dominant inherited disorder that ..
  77. Proteomic Validation of the Min Mouse Model of Colon Cancer
    Anthony Yeung; Fiscal Year: 2007
    ..Adenomatous Polyposis' (FAR) patient has inherited a heterozygous mutation in the tumor suppressor gene APC (adenomatous polyposis coli) and will most likely develop colon cancer in his/her lifetime often because of loss of ..
  78. Beta-catenin-specific regulation of the vitamin D pathway in colon cancer
    Stephen W Byers; Fiscal Year: 2012
    ..The development of virtually all colorectal cancer results from mutation in adenomatous polyposis coli (APC) or 2-catenin genes...
  79. Eva S Anton; Fiscal Year: 2016
    ..Our preliminary results show that Adenomatous Polyposis Coli (APC) serves an essential function in the development of polarized radial glial scaffold during brain development...
  80. REGULATION OF NEURONAL SYNAPTIC COMPONENTS
    Michele Jacob; Fiscal Year: 2009
    ..Our recent studies identify adenomatous polyposis coli (APC) as a key molecular player in interneuronal cholinergic synapse assembly in vivo...
  81. Beth A Weaver; Fiscal Year: 2015
    ..Aim 2 will determine whether tumors induced by reduction or mutation of the tumor suppressors p53 and APC (Adenomatous Polyposis Coli) are susceptible to aneuploidy-mediated cell death caused by reduction of CENP-E...
  82. MARK A PEIFER; Fiscal Year: 2015
    ..Most cases are initiated by mutations in the tumor suppressor Adenomatous polyposis coli (APC)...
  83. Calcium/Vitamin D, Biomarkers & Colon Polyp Prevention
    Roberd Bostick; Fiscal Year: 2009
    ..colorectal epithelium that have been found to be altered early in the two major colorectal carcinogenesis pathways (APC, -catenin, E-cadherin, MSH2), 2) cell cycle events in colorectal epithelial crypt cells (proliferation: Mib-1;..
  84. FUNCTION OF THE NOVEL PROTEIN EB1
    JENNIFER TIRNAUER; Fiscal Year: 2003
    ..early event in the development of colon cancer is loss of heterozygosity for the normal adenomatous polyposis coli (APC) gene. APC is normally expressed in the proliferative zone of the crypt border in the colon...
  85. Nan Gao; Fiscal Year: 2014
    ..90% hereditary and sporadic colorectal cancers are caused by initial mutation in the adenomatous polyposis coli (APC) gene...
  86. HERBERT TOD COHEN; Fiscal Year: 2014
    ..knockout mice and multiple intestinal neoplasia (Min) mice, which have a defect in the adenomatous polyposis coli (Apc) gene and have increased beta-catenin activity...
  87. Chunming Liu; Fiscal Year: 2016
    ..CRC is initiated by mutations of adenomatous polyposis coli (APC) and b-catenin genes, which result in abnormal activation of the Wnt signaling pathway...
  88. A model system to study the tumor suppressor APC and its role in Wnt regulation.
    David Roberts; Fiscal Year: 2013
    ..Loss-of-function mutations in the tumor suppressor protein, Adenomatous Polyposis Coli (APC), inappropriately activate the pathway and frequently initiate cancer progression...
  89. Animal model of Gardner's syndrome, a life threatening form of familial cancer
    Yong Sik Bong; Fiscal Year: 2013
    ..FAP is an autosomal dominant disease caused by a mutation in the adenomatous polyposis coli (APC) tumor suppressor gene and is characterized by gastrointestinal polyps...
  90. INTERACTION OF APC AND P53 IN COLORECTAL CARCINOGENESIS
    Satya Narayan; Fiscal Year: 2001
    ..The association of altered expression of adenomatous polyposis coli (APC) tumor suppressor gene with poor prognosis in colon cancer patients is well established; however, little is known ..
  91. Tumor suppressor adenomatous polyposis coli and breast carcinogenesis
    Satya Narayan; Fiscal Year: 2007
    Our overall goal is to determine the role of the adenomatous polyposis coli (APC) gene in DNA damage-induced DNA repair activity and breast carcinogenesis...
  92. APC TUMOR SUPPRESSOR PROTEIN IN DEVELOPMENT
    YASMATH AHMED; Fiscal Year: 2003
    Inactivation of the adenomatous polyposis coli (APC) tumor suppressor triggers the development of the majority of colorectal carcinomas...
  93. Ethan Lee; Fiscal Year: 2016
    ..Since its identification two decades ago, however, the function of APC in Wnt signaling remains poorly understood...
  94. p120 and Kaiso dysregulation in intestinal tumorigenesis
    SARAH PALMER SHORT; Fiscal Year: 2013
    ..Loss of the tumor suppressor adenomatous polyposis coli (APC) gene is the initiating mutation in ~80% of these cancers and the driving mutation behind familial adenomatous ..
  95. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2005
    ..and organization are important in neurite outgrowth, and cadherins and the protein adenomatous polyposis coli (APC) are well placed to play key roles in coordinating these changes...
  96. Analysis of the Chemopreventive Activity of FGN 1
    MARGIE CLAPPER; Fiscal Year: 2004
    ..by decreasing both nuclear levels of beta-catenin and the transcriptional activation of downstream targets of the APC/beta-catenin pathway...
  97. DETECTION OF ALTERED APC PROTEINS IN COLON CANCER CELLS
    David Hill; Fiscal Year: 1993
    Mutations in the APC gene appear to be crucial for adenoma formation in inherited Familial Adenomatous Polyposis (FAP) and in the early stages of colorectal cancer...