ANXA11

Summary

Gene Symbol: ANXA11
Description: annexin A11
Alias: ANX11, CAP50, annexin A11, 56 kDa autoantigen, CAP-50, annexin XI, annexin-11, autoantigen, 56-kD, calcyclin-associated annexin 50
Species: human

Top Publications

  1. ncbi Specific binding of CAP-50 to calcyclin
    H Minami
    Department of Pharmacology, Nagoya School of Medicine, Japan
    FEBS Lett 305:217-9. 1992
  2. ncbi Sequence and chromosomal localization of mouse annexin XI
    M P Fernandez
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Oviedo, Spain
    Genomics 37:366-74. 1996
  3. doi Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis
    Sylvia Hofmann
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel D 24105, Germany
    Nat Genet 40:1103-6. 2008
  4. doi Functional variant ANXA11 R230C: true marker of protection and candidate disease modifier in sarcoidosis
    F Mrazek
    Laboratory of Immunogenomics and Proteomics, Dept of Immunology, Medical Faculty of Palacky University and University Hospital, Olomouc, Czech Republic
    Genes Immun 12:490-4. 2011
  5. pmc Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis
    Alejandra Tomas
    Division of Cell Biology, Institute of Ophthalmology, 11 43 Bath St, London EC1V 9EL, England, UK
    J Cell Biol 165:813-22. 2004
  6. ncbi Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope
    Alejandra Tomas
    Division of Cell Biology, Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, United Kingdom
    J Biol Chem 278:20210-6. 2003
  7. ncbi Calcyclin (S100A6) regulates pulmonary fibroblast proliferation, morphology, and cytoskeletal organization in vitro
    Ellen C Breen
    Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla, California, USA
    J Cell Biochem 88:848-54. 2003
  8. ncbi The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner
    Hirokazu Satoh
    Laboratory of Molecular and Cellular Regulation, Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Biochim Biophys Acta 1600:61-7. 2002
  9. pmc Association of ANXA11 genetic variation with sarcoidosis in African Americans and European Americans
    A M Levin
    Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA
    Genes Immun 14:13-8. 2013
  10. ncbi ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner
    Hirokazu Satoh
    Laboratory of Molecular and Cellular Regulation, Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Biochem Biophys Res Commun 291:1166-72. 2002

Research Grants

Scientific Experts

Detail Information

Publications71

  1. ncbi Specific binding of CAP-50 to calcyclin
    H Minami
    Department of Pharmacology, Nagoya School of Medicine, Japan
    FEBS Lett 305:217-9. 1992
    ..e. other Ca(2+)-binding proteins with the EF-hand structure could not substitute for calcyclin, thereby suggesting the possible role in specific regulation of the function of CAP-50 by Ca2+/calcyclin...
  2. ncbi Sequence and chromosomal localization of mouse annexin XI
    M P Fernandez
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Oviedo, Spain
    Genomics 37:366-74. 1996
    Mouse annexin XI (anx11)2 was cloned from a macrophage cDNA library and characterized by genetic linkage mapping, DNA sequencing, and structural comparison with other annexins...
  3. doi Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis
    Sylvia Hofmann
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel D 24105, Germany
    Nat Genet 40:1103-6. 2008
    ..The strongest association signal maps to the ANXA11 (annexin A11) gene on chromosome 10q22.3...
  4. doi Functional variant ANXA11 R230C: true marker of protection and candidate disease modifier in sarcoidosis
    F Mrazek
    Laboratory of Immunogenomics and Proteomics, Dept of Immunology, Medical Faculty of Palacky University and University Hospital, Olomouc, Czech Republic
    Genes Immun 12:490-4. 2011
    In the recent genome-wide association study the polymorphisms of annexin A11 (ANXA11) gene were associated with susceptibility to sarcoidosis...
  5. pmc Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis
    Alejandra Tomas
    Division of Cell Biology, Institute of Ophthalmology, 11 43 Bath St, London EC1V 9EL, England, UK
    J Cell Biol 165:813-22. 2004
    ..Here, we show that during cell cycle progression annexin 11 translocates from the nucleus to the spindle poles in metaphase and to the spindle midzone in anaphase...
  6. ncbi Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope
    Alejandra Tomas
    Division of Cell Biology, Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, United Kingdom
    J Biol Chem 278:20210-6. 2003
    b>Annexin 11 is a widely expressed calcium- and phospholipid-binding protein that resides in the nucleoplasm in many cultured cell lines...
  7. ncbi Calcyclin (S100A6) regulates pulmonary fibroblast proliferation, morphology, and cytoskeletal organization in vitro
    Ellen C Breen
    Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla, California, USA
    J Cell Biochem 88:848-54. 2003
    ..These observations suggest a role for calcyclin in modulating calcium dependent signaling events that regulate progression through the cell cycle. J. Cell. Biochem. 88: 848-854, 2003...
  8. ncbi The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner
    Hirokazu Satoh
    Laboratory of Molecular and Cellular Regulation, Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Biochim Biophys Acta 1600:61-7. 2002
    ..We previously identified annexin XI as a novel ALG-2-binding partner...
  9. pmc Association of ANXA11 genetic variation with sarcoidosis in African Americans and European Americans
    A M Levin
    Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA
    Genes Immun 14:13-8. 2013
    ..in European populations found that a non-synonymous single-nucleotide polymorphism (SNP), rs1049550, within the annexin A11 (ANXA11) gene was associated with susceptibility to sarcoidosis...
  10. ncbi ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner
    Hirokazu Satoh
    Laboratory of Molecular and Cellular Regulation, Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Biochem Biophys Res Commun 291:1166-72. 2002
    ..using human ALG-2 as bait, we isolated a cDNA of a novel ALG-2-interacting protein, which turned out to be annexin XI. Deletion analysis revealed that ALG-2 interacted with the N-terminal domain of annexin XI (AnxN), which has an ..
  11. doi Annexin A11 gene polymorphism (R230C variant) and sarcoidosis in a Portuguese population
    A Morais
    Department of Pneumology, Hospital Sao Joao, Porto, Portugal Department of Medicine, Faculdade de Medicina do Porto, Porto, Portugal
    Tissue Antigens 82:186-91. 2013
    A recent genome-wide association study detected a protective effect for the annexin A11 rs1049550*T allele (R230Cvariant) in susceptibility to sarcoidosis...
  12. doi Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants
    Hideki Shibata
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya, Japan
    J Biol Chem 283:9623-32. 2008
    ..on binding ability to ALG-2(DeltaGF122): (i) isoform-non-interactive (ABS-1) types, including Alix, annexin A7, annexin A11, and TSG101 and (ii) isoform-interactive (ABS-2) types including PLSCR3, PLSCR4 and Sec31A...
  13. ncbi Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display
    Lauge Farnaes
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 278:33120-6. 2003
    ..b>Annexin XI, a member of the Ca2+-dependent, phospholipid-binding protein family, is an example of such a protein and was ..
  14. ncbi Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins
    R O Morgan
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universiry of Oviedo, Spain
    Genomics 48:100-10. 1998
    ..Fluorescence in situ hybridization localized human annexin XI (ANX11) to 10q22.3-q23.1 and annexin XIII (ANX13) to 8q24.1-q24.2...
  15. doi Associations between sarcoidosis clinical course and ANXA11 rs1049550 C/T, BTNL2 rs2076530 G/A, and HLA class I and II alleles
    Antonio Morais
    Pneumology Department, Centro Hospitalar São João, Porto, Portugal
    Clin Respir J . 2016
    ..We analyzed associations between sarcoidosis clinical course and HLA class I/II alleles and susceptibility gene SNPs ANXA11 rs1049550 C/T and BTNL2 rs2076530 G/A in a Portuguese population, investigating possible gene-gene interactions.
  16. doi Annexin A11 in disease
    Jiasheng Wang
    Department of Biotechnology, Dalian Medical University, Dalian 116044, China
    Clin Chim Acta 431:164-8. 2014
    Ubiquitously expressed in many cell types, annexin A11 (Anxa11) is a member of the multigene family of Ca(2+)-regulated phospholipid-dependent and membrane-binding annexin proteins...
  17. ncbi The Association between ANXA11 Gene Polymorphisms and Sarcoidosis: a Meta-Analysis and systematic review
    Hongfei Zhou
    Sarcoidosis Vasc Diffuse Lung Dis 33:102-11. 2016
    The associations of ANXA11 gene polymorphisms and susceptibility to sarcoidosis have been evaluated in recent years. However, the results remain controversial, especially in different ethnicity...
  18. pmc Annexin A11 (ANXA11) gene polymorphisms are associated with sarcoidosis in a Han Chinese population: a case-control study
    Xianjun Feng
    Department of Respiratory Medicine, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, PR China
    BMJ Open 4:e004466. 2014
    To further identify the single-nucleotide polymorphisms (SNPs) that contribute to the genetic susceptibility to sarcoidosis, we examined the potential association between sarcoidosis and 15 SNPs of the ANXA11 gene.
  19. pmc A new role for annexin A11 in the early secretory pathway via stabilizing Sec31A protein at the endoplasmic reticulum exit sites (ERES)
    Hideki Shibata
    From the Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan and
    J Biol Chem 290:4981-93. 2015
    ..In this study, we show that another calcium-binding protein, annexin A11 (AnxA11), physically associates with Sec31A by the adaptor function of ALG-2...
  20. doi Prostate cancer-associated autoantibodies in serum against tumor-associated antigens as potential new biomarkers
    Ramesh Ummanni
    Department of Oncology, Haematology, Hubertus Wald Tumour Zentrum UCCH, University Hospital Eppendorf UKE, Hamburg, Germany Center for Chemical Biology, Indian Institute of Chemical Technology IICT, Hyderabad, India Electronic address
    J Proteomics 119:218-29. 2015
    ..Autoantibody response to antigens PRDX2, PRDX6 and ANXA11 in PCa patient's sera was confirmed using recombinant antigens...
  21. doi Annexin A11 knockdown inhibits in vitro proliferation and enhances survival of Hca-F cell via Akt2/FoxO1 pathway and MMP-9 expression
    Shuqing Liu
    Department of Biochemistry, Dalian Medical University, Dalian 116044, China
    Biomed Pharmacother 70:58-63. 2015
    b>Annexin A11 (Anxa11), a Ca(2+)-regulated phospholipid-binding protein, is involved in cell apoptosis, differentiation, vesicle trafficking, cancer progression and autoimmune diseases...
  22. pmc Antigen-Antibody Affinity for Dry Eye Biomarkers by Label Free Biosensing. Comparison with the ELISA Technique
    Maríafe Laguna
    Center for Biomedical Technology, Optics, Photonics and Biophotonics Lab, Universidad Politécnica de Madrid Campus Montegancedo, 28223 Pozuelo de Alarcon, Madrid, Spain
    Sensors (Basel) 15:19819-29. 2015
    ..Different proteins involved with dry eye dysfunction: ANXA1, ANXA11, CST4, PRDX5, PLAA and S100A6; were validated as biomarkers...
  23. pmc ANXA11 regulates the tumorigenesis, lymph node metastasis and 5-fluorouracil sensitivity of murine hepatocarcinoma Hca-P cells by targeting c-Jun
    Shuqing Liu
    Department of Biochemistry, Dalian Medical University, Dalian 116044, China
    Oncotarget 7:16297-310. 2016
    b>Annexin A11 (Anxa11) is associated with various cancers...
  24. pmc Integrative radiogenomic analysis for genomic signatures in glioblastomas presenting leptomeningeal dissemination
    Hye Jin You
    aDepartment of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea bDepartments of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea cSamsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea dInstitute for Refractory Cancer Research, Samsung Medical Center, Seoul, Korea eSamsung Advanced Institute of Technology, Samsung Electronics Co Ltd, Seoul, Korea fDepartment of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Medicine (Baltimore) 95:e4109. 2016
    ..analysis using gene expression based on the change of copy number revealed that SPOCK1, EHD2, SLC2A3, and ANXA11 were highly expressed with the gain of copy number, compared with the gene expression in the non-LMD group...
  25. doi Feasibility of novel PPP1R15A and proposed ANXA11 single nucleotide polymorphisms as predictive markers for bevacizumab regimen in metastatic colorectal cancer
    Seon Ae Roh
    Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea
    J Cancer Res Clin Oncol 142:1705-14. 2016
    ..Bevacizumab improves survival in patients with metastatic colorectal cancer (mCRC) under chemotherapy, but few predictive markers have been identified...
  26. pmc Feasibility of proposed single-nucleotide polymorphisms as predictive markers for targeted regimens in metastatic colorectal cancer
    J C Kim
    Department of Surgery, University of Ulsan College of Medicine, Seoul, Korea
    Br J Cancer 108:1862-9. 2013
    ..Surrogate biomarkers for metastatic colorectal cancer (mCRC) are urgently needed to achieve the best outcomes for targeted therapy...
  27. doi MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
    Sonja I Buschow
    Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine and Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands
    Immunol Cell Biol 88:851-6. 2010
    ..These include HSC71, HSP90, 14-3-3ɛ, CD20 and pyruvate kinase type M2 (PKM2), and we speculate on the functionality of their interaction with exosomal MHC II...
  28. pmc Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2DeltaGF122) and structural roles of F122 in target recognition
    Tatsutoshi Inuzuka
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    BMC Struct Biol 10:25. 2010
    ..An alternatively spliced shorter isoform, designated ALG-2DeltaGF122, lacks Gly121Phe122 and does not bind Alix, but the structural basis of the incompetence has remained to be elucidated...
  29. pmc Valproic acid teratogenicity: a toxicogenomics approach
    Kim Kultima
    Department of Pharmaceutical Biosciences, Division of Toxicology, The Biomedical Center, Uppsala University, Uppsala, Sweden
    Environ Health Perspect 112:1225-35. 2004
    ..6, galectin-1 (Lgals1), inhibitor of DNA binding 1 (Idb1), fatty acid synthase (Fasn), annexins A5 and A11 (Anxa5, Anxa11)], or with VPA effects or known molecular actions of VPA (Lgals1, Mt1, Mt2, Id1, Fasn, Anxa5, Anxa11, Krt1-18)...
  30. pmc The effect of captopril on impaired wound healing in experimental diabetes
    Ehsan Zandifar
    Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
    Int J Endocrinol 2012:785247. 2012
    ..The animals of the first and second groups received 25 and 50 mg/kg/day captopril, respectively, (DM-cap25 and DM-cap50). The animals of the third group were treated by distilled water (DM-control). Control rats had no intervention...
  31. doi Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis
    Sylvia Hofmann
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Eur Respir J 41:888-900. 2013
    ..Expression analyses of OS9 mRNA provide evidence for a functional mechanism underlying the detected association signal...
  32. ncbi Evidence from studies on co-cultures of TtT/GF and AtT20 cells that Annexin 1 acts as a paracrine or juxtacrine mediator of the early inhibitory effects of glucocorticoids on ACTH release
    T Tierney
    Department of Neuroendocrinology, Division of Neuroscience and Psychological Medicine, Imperial College London, London, UK
    J Neuroendocrinol 15:1134-43. 2003
    ..The effects of Dex on ACTH release were mimicked by N-terminal ANXA1 fragments (ANXA1Ac2-26, 2 micro g/ml and ANXA11-188, 0...
  33. pmc Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility
    Indra Adrianto
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 7:e43907. 2012
    ..We replicated previous European GWAS associations within HLA-DRA, HLA-DRB5, HLA-DRB1, BTNL2, and ANXA11 in both our AA and EA datasets...
  34. pmc Fine-mapping in African-American women confirms the importance of the 10p12 locus to sarcoidosis
    Y C Cozier
    Slone Epidemiology Center at Boston University, Boston, MA 02215, USA
    Genes Immun 13:573-8. 2012
    ..SNPs) located in the intergenic region between the C10ORF67 and OTUD1 genes on chromosome 10p12, and the ANXA11 gene (chromosome 10q22)...
  35. doi Tear proteome and protein network analyses reveal a novel pentamarker panel for tear film characterization in dry eye and meibomian gland dysfunction
    J Soria
    Bioftalmik, Parque Tecnologico de Vizcaya, Ed 800, 2nd Floor, E 48160 Derio, Vizcaya, Spain
    J Proteomics 78:94-112. 2013
    ..sponge and capillary confirmed the high discriminatory power of five biomarkers: S100A6, annexin A1 (ANXA1), annexin A11 (ANXA11), cystatin-S (CST4), and phospholipase A2-activating protein (PLAA) with an area under ROC curve (AUC)..
  36. pmc Elevated expression levels of ANXA11, integrins β3 and α3, and TNF-α contribute to a candidate proteomic signature in urine for kidney allograft rejection
    Meera Srivastava
    Department of Anatomy, Physiology and Genetics, USU Center for Medical Proteomics, Uniformed Services University School of Medicine, Bethesda, MD, USA
    Proteomics Clin Appl 5:311-21. 2011
    ..We have hypothesized that protein biomarkers might be discovered in the urine of patients when acute or chronic rejection might be occurring...
  37. doi Anti-annexins autoantibodies: their role as biomarkers of autoimmune diseases
    L Iaccarino
    Division of Rheumatology, Department of Medicine, University of Padova, Via Giustiniani 2 35128 Padova, Italy
    Autoimmun Rev 10:553-8. 2011
    ..Anti-annexin V antibodies were also found in patients with pregnancy loss with or without APS. Annexin XI is involved in several biological pathways, particularly apoptosis and cell proliferation...
  38. ncbi Annexin A2 promotes choroidal neovascularization by increasing vascular endothelial growth factor expression in a rat model of argon laser coagulation-induced choroidal neovascularization
    Shi Hong Zhao
    Department of Ophthalmology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Chin Med J (Engl) 123:713-21. 2010
    ..This study aimed to investigate the relationship between annexin A2 (ANXA2) and vascular endothelial growth factor (VEGF) in CNV...
  39. pmc Novel protein ligands of the annexin A7 N-terminal region suggest pro-beta helices engage one another with high specificity
    Carl E Creutz
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    Gen Physiol Biophys 28:F7-F13. 2009
    ..Specificity of interactions between the pro-beta helices in different proteins may be encoded by the variations of residues and lengths of the sequence repeats...
  40. ncbi Characterisation of the sarcoidosis-associated variant of annexin A11
    Lux Fatimathas
    Department of Cell Biology, UCL Institute of Ophthalmology, London EC1V 9EL, United Kingdom
    Gen Physiol Biophys 28:F29-38. 2009
    ..single nucleotide polymorphism (SNP) that switches a highly conserved arginine to a cysteine at position 230 in annexin A11. The effect of the R230C SNP on the cellular distribution and Ca(2+)-sensitivity of annexin A11 was ..
  41. doi Myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7: corroboration and narrowing of the critical region on 10q22.3
    Angelika Kuhl
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
    Eur J Hum Genet 16:367-73. 2008
    ..genes to 18 of which 17 (RAI17, PPIF, C10ORF56, SFTPA1, SFTPA2, SFTPA1B, SFTPA2B, SFTPD, C10ORF57, PLAC9, ANXA11, MAT1A, DYDC1, DYDC2, C10ORF58, TSPAN14 and SH2D4B) are shared with the CMD1C region...
  42. pmc S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility
    T Nedjadi
    Division of Surgery and Oncology, University of Liverpool, Liverpool, UK
    Br J Cancer 101:1145-54. 2009
    ..High levels of S100A6 have been associated with poor outcome in pancreatic cancer patients. The functional role of S100A6 is, however, poorly understood...
  43. ncbi A structural basis for S100 protein specificity derived from comparative analysis of apo and Ca(2+)-calcyclin
    Lena Mäler
    Department of Biochemistry and Biophysics, Arrhenius Laboratory, Stockholm University, Sweden
    J Mol Biol 317:279-90. 2002
    ..models of calcyclin based on S100B, a binding site in calcyclin has been proposed for the N-terminal domain of annexin XI and the C-terminal domain of the neuronal calcyclin-binding protein...
  44. ncbi Identification of a novel mammalian annexin. cDNA cloning, sequence analysis, and ubiquitous expression of the annexin XI gene
    C A Towle
    Orthopaedic Research Laboratories, Massachusetts General Hospital, Boston, Massachusetts
    J Biol Chem 267:5416-23. 1992
    ..This report describes an additional member of this family, bovine annexin XI, identified by cDNA cloning and sequence analysis...
  45. ncbi Alternatively spliced annexin XI transcripts encode proteins that differ near the amino-terminus
    C A Towle
    Orthopaedic Research Laboratories, Massachusetts General Hospital, Boston 02114
    Biochim Biophys Acta 1131:223-6. 1992
    ..We recently described a new member of this family, bovine annexin XI [1]...
  46. ncbi The 56K autoantigen is identical to human annexin XI
    Y Misaki
    Department of Biochemistry, University of Nijmegen, The Netherlands
    J Biol Chem 269:4240-6. 1994
    ..5%) with bovine annexin XI, indicating that the 56K cDNA encodes the human homologue of annexin XI, a member of the Ca(2+)-dependent ..
  47. ncbi Isolation by calcium-dependent translation to neutrophil-specific granules of a 42-kD cytosolic protein, identified as being a fragment of annexin XI
    C Sjolin
    Phagocyte Research Laboratory, Department of Medical Microbiology and Immunology, University of Goteborg, Sweden
    Blood 87:4817-23. 1996
    ..Peptides from three peaks were N-terminally sequenced. Searching among known proteins, each one of the amino acid sequences was found to share sequence similarity to annexin XI.
  48. ncbi Translocation of annexin XI to neutrophil subcellular organelles
    C Sjolin
    Department of Medical Microbiology and Immunology, University of Goteborg, Sweden
    Biochim Biophys Acta 1326:149-56. 1997
    In an earlier study, annexin XI was found to be present in the cytosol of neutrophil granulocytes (Blood (1996) 87, 4817)...
  49. ncbi Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII)
    A M Brownawell
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 272:22182-90. 1997
    ..Therefore, the interaction between sorcin and synexin may serve to regulate the functions of these proteins on membrane surfaces in a Ca2+-dependent manner...
  50. ncbi The genetic origin of mouse annexin VIII
    M P Fernandez
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Oviedo, Spain
    Mamm Genome 9:8-14. 1998
    ..Cladistic analysis confirmed the base position of annexin XI and its relationship to annexin IV as a direct duplication product...
  51. ncbi Regulation of calcyclin (S100A6) binding by alternative splicing in the N-terminal regulatory domain of annexin XI isoforms
    T Sudo
    Department of Pharmacology, Nagoya University School of Medicine, Showa Ku, Nagoya, 466, Japan
    J Biol Chem 273:6351-7. 1998
    b>Annexin XI is a Ca2+/phospholipid-binding protein that interacts with a member of S100 protein family, calcyclin (S100A6), in a Ca2+-dependent manner...
  52. ncbi Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3
    A O Gure
    Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Res 58:1034-41. 1998
    ..The other three genes were annexin XI, human HIV Rev-interacting protein Rip-1, and the human homologue of the ATP-binding arsA component of the ..
  53. ncbi Characterization of the calcyclin (S100A6) binding site of annexin XI-A by site-directed mutagenesis
    T Sudo
    Department of Pharmacology, Nagoya University School of Medicine, Japan
    FEBS Lett 444:11-4. 1999
    Residues in annexin XI-A essential for binding of calcyclin (S100A6) were examined by site-directed mutagenesis...
  54. ncbi Calcium-dependent secretion in human neutrophils: a proteomic approach
    M Boussac
    CEA Laboratoire de Chimie des Protéines, Grenoble, France
    Electrophoresis 21:665-72. 2000
    ..proteins were shown to be secreted by activated neutrophils, namely calgranulins, human cartilage glycoprotein of 39 kDa (HC gp-39), chitotriosidase, and annexin XI. Their subcellular localization and possible functions are discussed.
  55. ncbi Construction of a high-resolution physical map of the chromosome 10q22-q23 dilated cardiomyopathy locus and analysis of candidate genes
    K R Bowles
    Department of Molecular and Human Genetics, Department of Pediatrics Cardiology, Department of Medicine, Department of Cardiovascular Sciences, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Genomics 67:109-27. 2000
    ..9 Mb long). Seven genes, including ANX11, PPIF, DLG5, RPC155, RPS24, SFTPA1, and KCNMA1, have been mapped to the region of interest...
  56. ncbi Annexin A11 (ANXA11) gene structure as the progenitor of paralogous annexins and source of orthologous cDNA isoforms
    P Bances
    Department of Biochemistry and Molecular Biology, Edificio Santiago Gascon, University of Oviedo, Oviedo, E 33006, Spain
    Genomics 69:95-103. 2000
    The genomic organization of the annexin A11 gene was determined in mouse and human to assess its congruity with other family members and to examine the species variation in alternative splicing patterns...
  57. pmc Suppression of annexin A11 in ovarian cancer: implications in chemoresistance
    Jin Song
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Neoplasia 11:605-14, 1 p following 614. 2009
    ..We have previously reported that annexin A11 is associated with cisplatin resistance and related to tumor recurrence in ovarian cancer patients...
  58. ncbi Proteolytic signals in the primary structure of annexins
    Junor A Barnes
    Biochemistry Unit, Faculty of Medical Sciences, The University of West Indies, St Augustine, Trinidad and Tobago
    Mol Cell Biochem 231:1-7. 2002
    ..Annexin V was found to be stable to intrinsic lung proteases in the presence of either Ca2+ or EGTA while annexin XI was found to be partially degraded by intrinsic lung proteases in the presence of EGTA...
  59. ncbi 17-Beta-estradiol regulates expression of genes that function in macrophage activation and cholesterol homeostasis
    P R Kramer
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University Health Science Center, 3302 Gaston Avenue, Dallas, TX, USA
    J Steroid Biochem Mol Biol 81:203-16. 2002
    ..data indicate that the transcript levels of interleukin 1 receptor antagonist (IL-1ra), beta 2-microglobulin, annexin XI and the LXR(alpha) receptor significantly increased and that Ly-GDI transcript levels significantly decreased ..
  60. ncbi The penta-EF-hand protein ALG-2 interacts with a region containing PxY repeats in Alix/AIP1, which is required for the subcellular punctate distribution of the amino-terminal truncation form of Alix/AIP1
    Hideki Shibata
    Laboratory of Molecular and Cellular Regulation, Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601
    J Biochem 135:117-28. 2004
    ..that belongs to the penta-EF-hand protein family and associates with several proteins, including annexin VII, annexin XI, and Alix/AIP1, in a Ca(2+)-dependent manner...
  61. ncbi Autoantibodies to Annexin XI-A and Other Autoantigens in the Diagnosis of Breast Cancer
    FELIX FERNANDEZ-MADRID
    Department of Internal Medicine, Division of Rheumatology, Wayne Stste University, 4201 St Antoine Boulevard, Detroit, MI 48201, USA
    Cancer Res 64:5089-96. 2004
    ..0001). Several autoantigens including annexin XI-A, the p80 subunit of the Ku antigen, ribosomal protein S6, and other unknown autoantigens could significantly ..
  62. ncbi Use of high-throughput protein array for profiling of differentially expressed proteins in normal and malignant breast tissue
    Gernot Hudelist
    Department of Obstetrics and Gynecology, Division of Special Gynecology, University of Vienna Medical Center, Vienna, Austria
    Breast Cancer Res Treat 86:281-91. 2004
    ..of proteins that show increased expression levels in malignant breast tissues such as casein kinase Ie, p53, annexin XI, CDC25C, eIF-4E and MAP kinase 7...
  63. ncbi Annexin XI co-localises with calcyclin in proliferating cells of the embryonic mouse testis
    Louise H Williams
    Murdoch Children s Research Institute and Department of Paediatrics, University of Melbourne, Parkville, Australia
    Dev Dyn 234:432-7. 2005
    ..Many elements of this pathway remain to be identified. Here, we characterise Annexin XI (Anxa11), a gene whose major site of embryonic expression was within the undifferentiated and differentiating ..
  64. ncbi Staphylokinase-annexin XI chimera exhibited efficient in vitro thrombolytic activities
    Jeng Fong Chiou
    Cancer Center and Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, Taiwan, ROC
    Biosci Biotechnol Biochem 71:1122-9. 2007
    ..Hence, a new option other than the most committed ANXV for the ANX based chimera without elaboration of linker construction is presented...
  65. ncbi Annexin XI is associated with cisplatin resistance and related to tumor recurrence in ovarian cancer patients
    Jin Song
    Department of Pathology, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, MD 21231, USA
    Clin Cancer Res 13:6842-9. 2007
    ..In this study, a protein identified to be associated with cisplatin resistance in ovarian cancer cells was investigated in ovarian cancer tissues to address its clinical significance...
  66. pmc Multiple-antigen immunization of chickens facilitates the generation of recombinant antibodies to autoantigens
    D Hof
    Department of Biomolecular Chemistry 271, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands
    Clin Exp Immunol 151:367-77. 2008
    ..display libraries, recombinant monoclonal antibody fragments were isolated successfully against the autoantigens annexin XI, centromere protein B, heat shock protein B3, DNA topoisomerase I, histidyl tRNA synthetase, Ro52, Ro60, Rpp30 ..
  67. ncbi Proteome analysis of matrix vesicles isolated from femurs of chicken embryo
    Marcin Balcerzak
    Department of Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St, Warsaw, Poland
    Proteomics 8:192-205. 2008
    ..Among the proteins recognized for the first time in MVs were aquaporin 1, annexin A1 (AnxA1), AnxA11, glycoprotein HT7, G(i) protein alpha2, and scavenger receptor type B...
  68. doi Evaluation of T7 and lambda phage display systems for survey of autoantibody profiles in cancer patients
    Zane Kalnina
    Biomedical Research and Study Centre of Latvia, Riga, Latvia
    J Immunol Methods 334:37-50. 2008
    ..only 24 represented known genes translated in their natural reading frame and included known TAAs like Annexin XI-A and a novel potential CT antigen SPAG8...
  69. doi Polymorphisms in the Annexin gene family and the risk of osteonecrosis of the femoral head in the Korean population
    Tae Ho Kim
    Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Jung Gu, Daegu, Republic of Korea
    Bone 45:125-31. 2009
    ..The aim of this study was to evaluate the possible association of AnnexinA (ANXA) family gene polymorphisms with ONFH...

Research Grants2

  1. CALCIUM DEPENDENT MEMBRANE BINDING PROTEINS
    CARL CREUTZ; Fiscal Year: 2002
    ....
  2. ANNEXIN PHOSPHORYLATION: CAUSES AND CONSEQUENCES
    CARL CREUTZ; Fiscal Year: 2004
    ....