ANK3

Summary

Gene Symbol: ANK3
Description: ankyrin 3
Alias: ANKYRIN-G, MRT37, ankyrin-3, ankyrin 3, node of Ranvier (ankyrin G)
Species: human

Top Publications

  1. ncbi AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier
    E Kordeli
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 270:2352-9. 1995
  2. ncbi Lateral membrane biogenesis in human bronchial epithelial cells requires 190-kDa ankyrin-G
    Krishnakumar Kizhatil
    Howard Hughes Medical Institute and Departments of Cell Biology, Biochemistry, and Neuroscience, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:16706-14. 2004
  3. ncbi Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells
    Krishnakumar Kizhatil
    Howard Hughes Medical Institute and Departments of Cell Biology, Biochemistry, and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:2029-37. 2007
  4. ncbi Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos
    Krishnakumar Kizhatil
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:26552-61. 2007
  5. pmc Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway
    John S Lowe
    Department of Internal Medicine, Division of Cardiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Cell Biol 180:173-86. 2008
  6. pmc Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
    Manuel A R Ferreira
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:1056-8. 2008
  7. pmc Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder
    T G Schulze
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 3719, USA
    Mol Psychiatry 14:487-91. 2009
  8. pmc Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort
    Lavinia Athanasiu
    Institute of Psychiatry, University of Oslo, P O 1130, Blindern, N 0318 Oslo, Norway
    J Psychiatr Res 44:748-53. 2010
  9. doi Genome-wide association study of bipolar I disorder in the Han Chinese population
    M T M Lee
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Mol Psychiatry 16:548-56. 2011
  10. doi Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression
    Emma M Quinn
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Ireland
    Bipolar Disord 12:440-5. 2010

Research Grants

  1. Peter J Mohler; Fiscal Year: 2016
  2. James Salzer; Fiscal Year: 2016
  3. THOMAS JEFFREY HUND; Fiscal Year: 2016
  4. Genomics-Guided Characterization of iPS Cells from Common Mental Illnesses
    Stephen J Haggarty; Fiscal Year: 2012
  5. Genomics-Guided Characterization of iPS Cells from Common Mental Illnesses
    STEPHEN JOHN HAGGARTY; Fiscal Year: 2010
  6. Tracey Petryshen; Fiscal Year: 2014
  7. Mario Delmar; Fiscal Year: 2015
  8. Mechanism and function of Kv channel targeting
    Chen Gu; Fiscal Year: 2013
  9. FGF14 IN THE REGULATION OF PURKINJE NEURON EXCITABILITY AND SCA27
    David M Ornitz; Fiscal Year: 2013
  10. Hemolytic Anemia: Models
    LUANNE PETERS; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications200 found, 100 shown here

  1. ncbi AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier
    E Kordeli
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 270:2352-9. 1995
    ..The neural-specific ankyrinG polypeptides are candidates to participate in maintenance/targeting of ion channels and cell adhesion molecules to nodes of Ranvier and axonal initial segments...
  2. ncbi Lateral membrane biogenesis in human bronchial epithelial cells requires 190-kDa ankyrin-G
    Krishnakumar Kizhatil
    Howard Hughes Medical Institute and Departments of Cell Biology, Biochemistry, and Neuroscience, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:16706-14. 2004
    ..Moreover, analysis of rat 190-kDa ankyrin G/ankyrin B chimeras shows that all three domains of 190-kDa ankyrin-G are required for preservation of the ..
  3. ncbi Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells
    Krishnakumar Kizhatil
    Howard Hughes Medical Institute and Departments of Cell Biology, Biochemistry, and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:2029-37. 2007
    ..These results demonstrate that ankyrin-G and beta(2)-spectrin are functional partners in biogenesis of the lateral membrane of epithelial cells...
  4. ncbi Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos
    Krishnakumar Kizhatil
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:26552-61. 2007
    ..Biol. Chem. 282, 2029-2037 ). Together with the current findings, these data suggest a ankyrin/spectrin-based mechanism for coordinating membrane assembly with extracellular interactions of E-cadherin at sites of cell-cell contact...
  5. pmc Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway
    John S Lowe
    Department of Internal Medicine, Division of Cardiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Cell Biol 180:173-86. 2008
    ..These data are the first report of a cellular pathway required for Na(v) channel trafficking in the heart and suggest that ankyrin-G is critical for cardiac depolarization and Na(v) channel organization in multiple excitable tissues...
  6. pmc Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
    Manuel A R Ferreira
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:1056-8. 2008
    ..1 x 10(-9)) in ANK3 (ankyrin G)...
  7. pmc Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder
    T G Schulze
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 3719, USA
    Mol Psychiatry 14:487-91. 2009
    Two recent reports have highlighted ANK3 as a susceptibility gene for bipolar disorder (BD)...
  8. pmc Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort
    Lavinia Athanasiu
    Institute of Psychiatry, University of Oslo, P O 1130, Blindern, N 0318 Oslo, Norway
    J Psychiatr Res 44:748-53. 2010
    ..The markers are located in PLAA, ACSM1 and ANK3, respectively...
  9. doi Genome-wide association study of bipolar I disorder in the Han Chinese population
    M T M Lee
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Mol Psychiatry 16:548-56. 2011
    ..15 × 10(-5)), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed ..
  10. doi Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression
    Emma M Quinn
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Ireland
    Bipolar Disord 12:440-5. 2010
    Genome-wide association studies (GWAS) have identified Ankyrin-G (ANK3) and the alpha-1C subunit of the L-type voltage-gated calcium channel (CACNA1C) as susceptibility genes for bipolar disorder...
  11. doi Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries
    Hywel J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Hum Mol Genet 20:387-91. 2011
    ..For BD, the strongly supported variants are in the vicinity of ankyrin 3, node of Ranvier (ANK3) and polybromo-1 (PBRM1)...
  12. doi Association of ANK3 with bipolar disorder confirmed in East Asia
    Atsushi Takata
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 156:312-5. 2011
    Results of genome-wide association studies (GWASs) for bipolar disorder (BD) have indicated ANK3 as one of the most promising candidates for a susceptibility gene...
  13. doi The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males
    Panos Roussos
    Department of Psychiatry and Behavioral Sciences, University of Crete, Heraklion, Greece
    Bipolar Disord 13:250-9. 2011
    The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with ..
  14. pmc Is Ankyrin a genetic risk factor for psychiatric phenotypes?
    Alejandro Gella
    Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Josep Trueta s n, Sant Cugat del Vallès 08195, Spain
    BMC Psychiatry 11:103. 2011
    Genome wide association studies reported two single nucleotide polymorphisms in ANK3 (rs9804190 and rs10994336) as independent genetic risk factors for bipolar disorder...
  15. doi ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype
    Tristram A P Lett
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada
    World J Biol Psychiatry 12:392-7. 2011
    OBJECTIVES. The ANK3, CACNA1C and ZNF804A genes have been implicated in both bipolar disorders (BPD) and schizophrenia (SCZ)...
  16. doi Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples
    Martin Tesli
    Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    Am J Med Genet B Neuropsychiatr Genet 156:969-74. 2011
    Genetic variants in ankyrin 3 (ANK3) have recently been shown to be associated with bipolar disorder (BD)...
  17. doi Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder
    D T Chen
    Human Genetics Branch, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Mol Psychiatry 18:195-205. 2013
    ..4 × 10(-11) level, with no heterogeneity. Supportive evidence for prior association findings near ANK3 and a locus on chromosome 3p21.1 was also observed...
  18. doi Sequencing of the ANKYRIN 3 gene (ANK3) encoding ankyrin G in bipolar disorder reveals a non-conservative amino acid change in a short isoform of ankyrin G
    Alexandra Dedman
    Molecular Psychiatry Laboratory, Mental Health Sciences Unit, University College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 159:328-35. 2012
    ..ss469104599) which causes a non-conservative amino acid change at position 794 in the shorter isoforms of the ankyrin G protein...
  19. doi ANK3 and CACNA1C--missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples
    Stefan Kloiber
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, Munich, Germany
    J Psychiatr Res 46:973-9. 2012
    Recent genome-wide association studies (GWAS) and metaanalyses revealed genetic associations for ANK3 (ankyrin 3) and CACNA1C (alpha 1C subunit of the L-type voltage gated calcium channel) with bipolar disorder (BPD)...
  20. pmc Cis-acting regulation of brain-specific ANK3 gene expression by a genetic variant associated with bipolar disorder
    E H Rueckert
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics, Research, Massachusetts General Hospital, Boston, MA, USA
    Mol Psychiatry 18:922-9. 2013
    Several genome-wide association studies for bipolar disorder (BD) have found a strong association of the Ankyrin 3 (ANK3) gene...
  21. pmc The cognitive impact of the ANK3 risk variant for bipolar disorder: initial evidence of selectivity to signal detection during sustained attention
    Gaia Ruberto
    Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 6:e16671. 2011
    ..a strong association with BD in a single nucleotide polymorphism (SNP) (rs10994336) within ANK3, which codes for Ankyrin 3. This protein is involved in facilitating the propagation of action potentials by regulating the assembly of ..
  22. doi Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia
    Panos Roussos
    Department of Psychiatry, The Mount Sinai School of Medicine, Bronx, NY 10468, USA
    Arch Gen Psychiatry 69:7-15. 2012
    ....
  23. ncbi The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes
    Peter J Mohler
    Howard Hughes Medical Institute and Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:10599-607. 2002
    ..C-terminal domains are the most divergent between ankyrin isoforms and are candidates to encode the signal(s) that enable ankyrins to selectively target proteins to diverse cellular sites...
  24. ncbi Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6
    Emi Shirahata
    Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan
    J Neurophysiol 96:1347-57. 2006
    ..6. These results suggest that ankyrin-G regulates neuronal excitability not only through clustering Nav channels but also by directly modifying their channel gating...
  25. pmc Na,K-ATPase transport from endoplasmic reticulum to Golgi requires the Golgi spectrin-ankyrin G119 skeleton in Madin Darby canine kidney cells
    P Devarajan
    Department of Pediatrics, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 94:10711-6. 1997
    ....
  26. doi An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan
    Gai Ayalon
    Howard Hughes Medical Institute and Departments of Cell Biology, Biochemistry, and Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Cell 135:1189-200. 2008
    ..Dynactin-4 and a subset of microtubules disappear from sarcolemmal sites in ankyrin-B-depleted muscle. Ankyrin-B thus is an adaptor required for sarcolemmal localization of dystrophin, as well as dynactin-4...
  27. ncbi Na,K-ATPase in skeletal muscle: two populations of beta-spectrin control localization in the sarcolemma but not partitioning between the sarcolemma and the transverse tubules
    M W Williams
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Cell Sci 114:751-62. 2001
    ..Both alpha subunits of the Na,K-ATPase colocalize with beta-spectrin and ankyrin 3 in costameres, structures at the sarcolemma that lie over Z and M-lines and in longitudinal strands...
  28. pmc Modulation of p53 activity by IkappaBalpha: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors
    David H Dreyfus
    Division of Basic Sciences, Department of Pediatrics, National Jewish Medical Research Center, Denver, CO 80262 USA
    BMC Immunol 6:12. 2005
    ..Interactions between the two proteins, both direct and indirect, have been noted previously and the two proteins play central roles in the control of proliferation and apoptosis...
  29. doi Long-term increasing co-localization of SCN8A and ankyrin-G in rat hippocampal cornu ammonis 1 after pilocarpine induced status epilepticus
    Ziyi Chen
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, 58th Zhongshan 2nd Road, Guangzhou, PR China
    Brain Res 1270:112-20. 2009
    ..001; F(day)=45.310, P<0.001). The data revealed that both SCN8A and ankyrin-G increased significantly in the CA1 subfield of the rat hippocampus 60 days following pilocarpine induced status epilepticus and co-localized with each other...
  30. pmc A cardiac arrhythmia syndrome caused by loss of ankyrin-B function
    Peter J Mohler
    Howard Hughes Medical Institute and Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 101:9137-42. 2004
    ....
  31. ncbi Identification of Ank(G107), a muscle-specific ankyrin-G isoform
    Claire Gagelin
    Biologie Cellulaire des Membranes, Departement de Biologie Cellulaire, Institut Jacques Monod, UMR 7592, CNRS Universités Paris 6 et Paris 7, 2 place Jussieu, 75251 Paris Cedex 05, France
    J Biol Chem 277:12978-87. 2002
    We previously showed that alternatively spliced ankyrins-G, the Ank3 gene products, are expressed in skeletal muscle and localize to the postsynaptic folds and to the sarcoplasmic reticulum...
  32. ncbi Polarized distribution of ion channels within microdomains of the axon initial segment
    Audra Van Wart
    Graduate Program in Neuroscience, Department of Neurobiology and Behavior, State University of New York, Stony Brook, New York 11794 5230, USA
    J Comp Neurol 500:339-52. 2007
    ..This precise arrangement of ion channels within the axon initial segment is likely an important determinant of the firing properties of ganglion cells and other mammalian neurons...
  33. pmc Cardiac ankyrins in health and disease
    Seyed M Hashemi
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    J Mol Cell Cardiol 47:203-9. 2009
    ..More broadly, these findings illustrate the importance of local membrane organization for normal cardiac physiology...
  34. pmc Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin G
    Aline Brechet
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 641, Marseille F 13916, France
    J Cell Biol 183:1101-14. 2008
    ..precise accumulation of sodium channels at the axonal initial segment (AIS) and in the nodes of Ranvier through ankyrin G scaffolding. We found that the ankyrin-binding motif of Na(v)1...
  35. ncbi Functional interaction between Rh proteins and the spectrin-based skeleton in erythroid and epithelial cells
    V Nicolas
    INSERM, U665, F 75015 Paris, France
    Transfus Clin Biol 13:23-8. 2006
    ..Similarly, binding to ankyrin G is required for cell surface expression of the non-erythroid member of the Rh protein family, RhBG, at the ..
  36. pmc Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains
    Hee Jung Chung
    Departments of Physiology and Biochemistry, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 103:8870-5. 2006
    ..We further show that several BFNC mutations of KCNQ2 and KCNQ3 disrupt surface expression or polarized surface distribution of KCNQ channels, thereby revealing impaired targeting of KCNQ channels to axonal surfaces as a BFNC etiology...
  37. pmc The C-terminal domain of ßIV-spectrin is crucial for KCNQ2 aggregation and excitability at nodes of Ranvier
    Jérôme J Devaux
    Département Signalisation Neuronale, CRN2M, UMR 6231, CNRS, Faculte de Medecine Secteur Nord, Université de la Méditerranée Université Paul Cézanne, CS80011, Bd Pierre Dramard, 13344 Marseille Cedex 15, France
    J Physiol 588:4719-30. 2010
    ..These findings demonstrate that spectrin cytoskeleton finely regulates ion channel distribution and implicates KCNQ2/3 subunits in axonal excitability and in myokymia aetiology...
  38. ncbi Specific role of the truncated betaIV-spectrin Sigma6 in sodium channel clustering at axon initial segments and nodes of ranvier
    Yoko Uemoto
    Department of Biological Sciences, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    J Biol Chem 282:6548-55. 2007
    ..By contrast, the levels of ankyrin G and voltage-gated sodium channels at these sites, which are significantly reduced in Sigma1Sigma6(-/-) mice, ..
  39. pmc Axo-glial interactions regulate the localization of axonal paranodal proteins
    J L Dupree
    Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Cell Biol 147:1145-52. 1999
    ....
  40. pmc Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates
    Alexis S Hill
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Genet 4:e1000317. 2008
    ..The early chordate refinements in action potential mechanisms we have elucidated appear essential to the complex neural signaling, active behavior, and evolutionary success of vertebrates...
  41. pmc Genome-wide association study of bipolar disorder in European American and African American individuals
    E N Smith
    Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, CA, USA
    Mol Psychiatry 14:755-63. 2009
    ..whether we could provide support for three regions previously associated with BD, and we showed that the ANK3 region replicates in our sample, along with some support for C15Orf53; other evidence implicates BD candidate genes ..
  42. ncbi Molecular alterations underlie nodal and paranodal degeneration in type 1 diabetic neuropathy and are prevented by C-peptide
    Anders A F Sima
    Wayne State University, Department of Pathology, 540 E Canfield Avenue, Detroit, MI 48201, USA
    Diabetes 53:1556-63. 2004
    ..These data describe for the first time the progressive molecular aberrations underlying nodal and paranodal degenerative changes in type 1 diabetic neuropathy and demonstrate that they are preventable by insulinomimetic C-peptide...
  43. doi Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments
    Pierre Marie Martin
    Unité Mixte de Recherche S 839, INSERM, Universite Pierre et Marie Curie, Institut du Fer a Moulin, Paris 75005, France
    J Neurosci 28:6111-7. 2008
    ..Na(v)), NF186 (neurofascin 186), NrCAM (neuron glia-related cell adhesion molecule), and cytoskeleton linkers ankyrin G (AnkG) and betaIV-spectrin...
  44. pmc The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression
    Frank A Simmen
    Department of Physiology and Biophysics, and the Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Reprod Biol Endocrinol 6:41. 2008
    ..This cell line provides a unique model for identifying KLF9 downstream gene targets and signaling pathways...
  45. doi Genetics of psychosis; insights from views across the genome
    Michael C O'Donovan
    Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Heath Park, Cardiff CF23 6BQ, UK
    Hum Genet 126:3-12. 2009
    ..locus in schizophrenia and for the calcium channel, voltage-dependent, L type, alpha 1C subunit (CACNA1C) and ankyrin 3, node of Ranvier (ANK3) loci in bipolar disorder...
  46. ncbi AnkyrinG is associated with the postsynaptic membrane and the sarcoplasmic reticulum in the skeletal muscle fiber
    E Kordeli
    Biologie Cellulaire des Membranes, Département de Biologie Supramoléculaire et Cellulaire, Institut Jacques Monod, CNRS Universités Paris 6 et Paris 7, 75251, Paris Cédex O5, France
    J Cell Sci 111:2197-207. 1998
    ..Ank1 and Ank3 transcripts were previously detected in skeletal muscle by northern blot analysis...
  47. ncbi Molecular domains of myelinated axons
    E Peles
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Curr Opin Neurobiol 10:558-65. 2000
    ..Recently, distinct protein complexes of cell adhesion molecules, Na(+) channels and ankyrin G at the nodes, Caspr and contactin in the paranodes, and K(+) channels and Caspr2 in the juxtaparanodal region ..
  48. ncbi No blocking effects of the pentapeptide QYNAD on Na+ channel subtypes expressed in Xenopus oocytes or action potential conduction in isolated rat sural nerve
    Stefan Quasthoff
    Department of Neurology, Karl Franzens University, Auenbruggerplatz 22, A 8036 Graz, Austria
    Neurosci Lett 352:93-6. 2003
    ..However, in a protein library search the amino acid sequence of QYNAD was found to be related to ankyrin-G, which plays a role in Na(+) channel clustering in the node of Ranvier...
  49. ncbi Molecular evolution of ankyrin: gain of function in vertebrates by acquisition of an obscurin/titin-binding-related domain
    Alexander A Hopitzan
    Institut Jacques Monod CNRS Universités Paris VI et VII, Paris, France
    Mol Biol Evol 23:46-55. 2006
    ..has identified one Caenorhabditis elegans (unc-44), two Drosophila (Dank1, Dank2), and three mammalian (Ank1, Ank2, Ank3) genes...
  50. pmc Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells
    Maria Carmen Inda
    Departamento de Biologia Celular, Universidad Complutense de Madrid, Jose Antonio Novais 2, 28040 Madrid, Spain
    Proc Natl Acad Sci U S A 103:2920-5. 2006
    ..Na+ channels distributed along the length of the AIS together with the associated proteins spectrin betaIV and ankyrin G. In contrast, Kv1...
  51. ncbi Vaccinia virus K1L protein supports viral replication in human and rabbit cells through a cell-type-specific set of its ankyrin repeat residues that are distinct from its binding site for ACAP2
    Xiangzhi Meng
    Department of Microbiology and Immunology, Univ of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Virology 353:220-33. 2006
    ..here that a large portion of the K1L protein, except ankyrin repeat 1 (ANK1) and C-terminal halves of ANK2 and ANK3, can be deleted or substituted with an unrelated ANK with no adverse effect on VV replication in human HeLa cells...
  52. pmc Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry
    Laura J Scott
    Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 106:7501-6. 2009
    ..In addition, we replicated the reported ANK3 association results for SNP rs10994336 in the nonoverlapping GSK sample (OR = 1.37, P = 0.042)...
  53. doi Heat opens axon initial segment sodium channels: a febrile seizure mechanism?
    Evan A Thomas
    Howard Florey Institute, University of Melbourne, Parkville, Australia
    Ann Neurol 66:219-26. 2009
    ..We measured the temperature sensitivity of the brain sodium channel, Na(V)1.2, to determine whether febrile temperatures might produce a direct increase in neuronal excitability...
  54. pmc Cultured subventricular zone progenitor cells transduced with neurogenin-2 become mature glutamatergic neurons and integrate into the dentate gyrus
    Xia Chen
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e31547. 2012
    ..Moreover, some neurons extended dendrites into the molecular layer, grew axons containing Ankyrin G+ axonal initial segments, and projected into the CA3 region, thus resembling mature DG granule neurons...
  55. doi Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice
    A C Santuccione
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Mol Psychiatry 18:358-68. 2013
    ..proteins, we found in AD patients high serum levels of antibodies against the neuronal cytoskeletal protein ankyrin G (ankG); these correlated with slower rates of cognitive decline...
  56. doi Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons
    Maren Engelhardt
    Center for Biomedicine and Medical Technology Mannheim, Research Division Neuroanatomy, Medical Faculty Mannheim, Heidelberg University, Ludolf Krehl Str 13 17, 68167 Mannheim, Germany
    Brain Struct Funct 218:1005-16. 2013
    ..Instead, we propose that ankyrin-B serves as a major membrane organizer in mechanoreceptive and nociceptive terminals of the PNS. ..
  57. pmc Developmental expression of Kv potassium channels at the axon initial segment of cultured hippocampal neurons
    Diana Sanchez-Ponce
    Department of Functional and Systems Neurobiology, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    PLoS ONE 7:e48557. 2012
    ..The accumulation of Kv1.2 and Kv2.2 subunits at the AIS was dependent on ankyrin G tethering, it was not affected by disruption of the actin cytoskeleton and it was resistant to detergent ..
  58. pmc E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin
    Paul M Jenkins
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 288:14018-31. 2013
    ..Together, the combination of retention and editing function to ensure a high fidelity steady state localization of E-cadherin at the lateral membrane...
  59. pmc Intracellular domain fragment of CD44 alters CD44 function in chondrocytes
    Liliana Mellor
    Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    J Biol Chem 288:25838-50. 2013
    ..The data suggest that release of the CD44 intracellular domain into the cytoplasm of cells such as chondrocytes exerts a competitive or dominant-negative effect on the function of full-length CD44. ..
  60. pmc Polarization of membrane associated proteins in the choroid plexus epithelium from normal and slc4a10 knockout mice
    Inga B Christensen
    Department of Biomedicine, Faculty of Health, Aarhus University Aarhus, Denmark
    Front Physiol 4:344. 2013
    ..The observations allow the generation of new hypotheses on basic cell biological paradigms that can be tested experimentally in future studies...
  61. doi A genetic variant in the seed region of miR-4513 shows pleiotropic effects on lipid and glucose homeostasis, blood pressure, and coronary artery disease
    Mohsen Ghanbari
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    Hum Mutat 35:1524-31. 2014
    ..to identify miR-4513 target genes that may mediate these associations and revealed five genes (PCSK1, BNC2, MTMR3, ANK3, and GOSR2) through which these effects might be taking place...
  62. pmc Glial ankyrins facilitate paranodal axoglial junction assembly
    Kae Jiun Chang
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA
    Nat Neurosci 17:1673-81. 2014
    ..Thus, glial ankyrins function as major scaffolds that facilitate early and efficient paranodal junction assembly in the developing CNS. ..
  63. pmc Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling
    Paul M Jenkins
    Howard Hughes Medical Institute and Department of Biochemistry
    Proc Natl Acad Sci U S A 112:957-64. 2015
    ..to I-connectin/Titin and was acquired after the first round of whole-genome duplication by the ancestral ANK2/ANK3 gene in early vertebrates before development of myelin...
  64. pmc Evidence of a structural and functional ammonium transporter RhBG·anion exchanger 1·ankyrin-G complex in kidney epithelial cells
    Sandrine Genetet
    From INSERM U1134, 75739 Paris, France, the Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, 75739 Paris, France, the Institut National de la Transfusion Sanguine, 75739 Paris, France, and the Laboratoire d Excellence GR Ex, 75238 Paris, France
    J Biol Chem 290:6925-36. 2015
    ..This renal complex could participate in the regulation of acid-base homeostasis. ..
  65. pmc Myelin loss and axonal ion channel adaptations associated with gray matter neuronal hyperexcitability
    Mustafa S Hamada
    Department of Axonal Signaling, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, 1105 BA Amsterdam, The Netherlands, and
    J Neurosci 35:7272-86. 2015
    ..In contrast, while the AIS in demyelinated axons started more closely to the soma, ankyrin G, βIV-spectrin, and the ion channel expression were maintained...
  66. doi GABA/Glutamate synaptic pathways targeted by integrative genomic and electrophysiological explorations distinguish autism from intellectual disability
    F Bonnet-Brilhault
    INSERM, U930, Tours, France
    Mol Psychiatry 21:411-8. 2016
    ..ASD patients from each family identified a second rare inherited genetic variant, affecting either the GLRB or the ANK3 genes encoding NLGN4X interacting proteins expressed in inhibitory or in excitatory synapses, respectively...
  67. pmc Molecular neurobiological clues to the pathogenesis of bipolar disorder
    Paul J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom Electronic address
    Curr Opin Neurobiol 36:1-6. 2016
    ..Recent genome-wide association studies have identified the first loci, implicating genes such as CACNA1C and ANK3. The genes highlight several pathways, notably calcium signalling, as being of importance...
  68. doi Human Neuroma-in-Continuity Contains Focal Deficits in Myelination
    Arie C van Vliet
    From the Department of Neuroregeneration, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences ACvV, MRT, JV, MJAM, FDW and Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Neuroscience Campus Amsterdam JV, Amsterdam and Departments of Neurosurgery ACvV, MJAM, FDW, Neurology MRT, and Pathology SvD, Leiden University Medical Center, Leiden, The Netherlands
    J Neuropathol Exp Neurol 74:901-11. 2015
    ..e., FMDs contained significantly fewer clustered Na(v)1.6 channels and decreased Caspr and ankyrin G)...
  69. pmc Ankyrin-3 as a molecular marker of early-life stress and vulnerability to psychiatric disorders
    A Luoni
    Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
    Transl Psychiatry 6:e943. 2016
    ..We identified Ankyrin-3 (Ank3), a scaffolding protein with a strong genetic association for psychiatric disorders, as a gene persistently ..
  70. pmc Restriction of 480/270-kD ankyrin G to axon proximal segments requires multiple ankyrin G-specific domains
    X Zhang
    Howard Hughes Medical Institute and Departments of Cell Biology and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Cell Biol 142:1571-81. 1998
    ..This complex behavior explains ability of ankyrinB and ankyrinG to sort to distinct sites in neurons and the fact that these ankyrins do not compensate for each other in ankyrin gene knockouts in mice...
  71. pmc betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system
    S Berghs
    Department of Internal Medicine, Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Cell Biol 151:985-1002. 2000
    ..Thus, we suggest that betaIVSigma1 spectrin interacts with ankyrin(G) 480/270-kD and participates in the clustering of voltage-gated Na(+) channels and cell-adhesion molecules at initial segments and nodes of Ranvier...
  72. ncbi Skin-specific expression of ank-3(93), a novel ankyrin-3 splice variant
    B Peters
    Institute of Genetics and Bonner Forum Biomedizin, University of Bonn, Römerstr 164, 53117 Bonn, Germany
    J Invest Dermatol 116:216-23. 2001
    ..Our data on ankyrin-3(93), which lacks a part of the spectrin-binding domain that regulates the affinity to spectrin, suggests a new function for this member of the ankyrin family...
  73. ncbi Ankyrin-based cardiac arrhythmias: a new class of channelopathies due to loss of cellular targeting
    Peter J Mohler
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Curr Opin Cardiol 20:189-93. 2005
    ..The focus is on ankyrins, a family of proteins that localize diverse membrane ion channels and transporters, and recent evidence that mutations affecting functions of ankyrins result in cardiac arrhythmia...
  74. ncbi Ankyrins and human disease: what the electrophysiologist should know
    Peter J Mohler
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Cardiovasc Electrophysiol 17:1153-9. 2006
    ..Moreover, these data define an exciting new field of cardiac "channelopathies" due to defects in proper channel targeting/localization...
  75. pmc Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals
    Luis F Lopez-Santiago
    Department of Pharmacology, University of Michigan, 1301 MSRB III, Ann Arbor, MI 48109 0632, USA
    J Mol Cell Cardiol 43:636-47. 2007
    ..Together, these results suggest that beta1 is critical for normal cardiac excitability and loss of beta1 may be associated with a long QT phenotype...
  76. doi Anti-GD1a antibodies activate complement and calpain to injure distal motor nodes of Ranvier in mice
    Rhona McGonigal
    University of Glasgow Division of Clinical Neurosciences, Glasgow Biomedical Research Centre, Room B330, 120 University Place, Glasgow G12 8TA, UK
    Brain 133:1944-60. 2010
    ..Complete loss of nodal protein staining, including voltage-gated sodium channels and ankyrin G, occurs and is completely protected by both complement and calpain inhibition, although the latter provides no ..
  77. pmc Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD
    Heike Weber
    Department of Psychiatry, Psychosomatics and Psychotherapy, Psychiatric Neurobiology and Bipolar Disorder Program, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 36:2076-85. 2011
    ..To address these issues, we genotyped SNPs in ANK3, CACNA1C, CMTM8, DGKH, EGFR, and NPAS3, which were significantly associated with BPD in previous GWAS, in a sample ..
  78. pmc A pathway for the control of anoikis sensitivity by E-cadherin and epithelial-to-mesenchymal transition
    Sanjeev Kumar
    Department of Biochemistry and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, USA
    Mol Cell Biol 31:4036-51. 2011
    ..P14ARF sensitized cells to anoikis; conversely, the TBX2/NRAGE complex protected cells against anoikis by downregulating this gene. This represents a novel pathway for the regulation of anoikis by EMT and E-cadherin...
  79. pmc Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly
    Meng He
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 287:43995-4005. 2012
    ....
  80. pmc FGF14 localization and organization of the axon initial segment
    Maolei Xiao
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Neurosci 56:393-403. 2013
    The axon initial segment (AIS) is highly enriched in the structural proteins ankyrin G and βIV-spectrin, the pore-forming (α) subunits of voltage-gated sodium (Nav) channels, and functional Nav channels, and is critical for the ..
  81. pmc Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons
    Joshua Barry
    Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    Dev Cell 28:117-31. 2014
    ..2, channels in mouse cerebellum. These results indicate that AnkG functions as an adaptor to link Nav channels to KIF5 during axonal transport before anchoring them to the AIS and nodes of Ranvier. ..
  82. pmc Long-term maintenance of Na+ channels at nodes of Ranvier depends on glial contact mediated by gliomedin and NrCAM
    Veronique Amor
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel W M Keck Center for Collaborative Neuroscience, Rutgers University, Piscataway, New Jersey 08854 and Department of Neuroscience and Physiology, New York University School of Medicine, New York, New York 10016
    J Neurosci 34:5089-98. 2014
    ..orderly manner, starting with the disappearance of neurofascin 186, followed by the loss of Na(+) channels and ankyrin G, and then βIV spectrin, a sequence that reflects the assembly of nodes during development...
  83. pmc Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly
    Meng He
    Department of Pharmacology and Cancer Biology, Department of Cell Biology, Department of Biochemistry, and Department of Neurobiology, Duke University Medical Center, Durham, NC 27710
    J Cell Biol 206:273-88. 2014
    ....
  84. pmc Neuroinformatic analyses of common and distinct genetic components associated with major neuropsychiatric disorders
    Amit Lotan
    Department of Adult Psychiatry and the Biological Psychiatry Laboratory, Hadassah Hebrew University Medical Center Jerusalem, Israel
    Front Neurosci 8:331. 2014
    ..The most widely shared subset of genes-common to five of six disorders-included ANK3, AS3MT, CACNA1C, CACNB2, CNNM2, CSMD1, DPCR1, ITIH3, NT5C2, PPP1R11, SYNE1, TCF4, TENM4, TRIM26, and ZNRD1...
  85. doi Molecular mechanism of regulation of villus cell Na-K-ATPase in the chronically inflamed mammalian small intestine
    Prosenjit Saha
    Department of Clinical and Translational Sciences, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA
    Biochim Biophys Acta 1848:702-11. 2015
    ..Therefore, altered localization of Na-K-ATPase as a result of transcriptional down-regulation of ankyrin-G mediates the down-regulation of Na-K-ATPase activity during chronic intestinal inflammation...
  86. doi Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B
    Pablo Muñoz-Llancao
    Laboratory of Cell and Neuronal Dynamics, Department of Biology, Faculty of Sciences, Universidad de Chile, 7800024 Santiago, Chile, Department of Molecular Pharmacology, University of Groningen, The Netherlands
    J Neurosci 35:11315-29. 2015
    ..Moreover, 8-pCPT-treated neurons expressed ankyrin G and other markers of mature axons such as synaptophysin and axonal accumulation of vGLUT1...
  87. doi [Change of Ankyrin G Promoter Activity Following Treatment with Sodium Valproate at Different Concentrations]
    Cui Liu
    Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Key Laboratory of Human Diseases Comparative Medicine of Ministry of Health, Institute of Medical Laboratory Animal Science, CAMS and PUMC, Beijing 100021, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 37:508-13. 2015
    To investigate whether sodium valproate (VPA) directly regulates the activity of Ankyrin G(AnkG) promoter in vitro.
  88. pmc Improved Methods for Fluorescence Microscopy Detection of Macromolecules at the Axon Initial Segment
    Musaad A Alshammari
    Graduate Studies Abroad Program, King Saud UniversityRiyadh, Saudi Arabia Department of Pharmacology and Toxicology, University of Texas Medical BranchGalveston, TX, USA
    Front Cell Neurosci 10:5. 2016
    ....
  89. doi Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated Na+ channels
    Pierluigi Valente
    Department of Experimental Medicine, University of Genova, Viale Benedetto XV, 3, Genova 16132, Italy
    J Cell Sci 129:1878-91. 2016
    ..leads to impairment of action potential initiation, most likely due to the loss of the interaction of L1 with ankyrin G that produces the delocalization of Na(+) channels at the axonal initial segment...
  90. doi Mood, stress and longevity: convergence on ANK3
    S Rangaraju
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Mol Psychiatry 21:1037-49. 2016
    ..The top gene identified was ANK3. To validate our findings, we conducted genetic and gene-expression studies, in C. elegans and in humans...
  91. pmc Effects of ANK3 variation on gray and white matter in bipolar disorder
    E T C Lippard
    Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
    Mol Psychiatry . 2016
    The single-nucleotide polymorphism rs9804190 in the Ankyrin G (ANK3) gene has been reported in genome-wide association studies to be associated with bipolar disorder (BD)...
  92. doi The impact of early environmental interventions on structural plasticity of the axon initial segment in neocortex
    Masoumeh Nozari
    Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran
    Dev Psychobiol 59:39-47. 2017
    ..We used Ankyrin G immunoreactivity to mark the AIS of cortical neurons in two sub-regions of frontal cortex (frontal association ..
  93. pmc Association analysis of ANK3 gene variants with schizophrenia in a northern Chinese Han population
    Xiaojuan Guo
    Xi an Mental Health Center, Xi an, Shaanxi 710061, China
    Oncotarget 7:85888-85894. 2016
    ..of 499 schizophrenia patients and 500 controls to investigate the effect of variant genotypes of 13 SNPs in ANK3 on schizophrenia risk...
  94. ncbi Fine genetic map of mouse chromosome 10 around the polycystic kidney disease gene, jcpk, and ankyrin 3
    E C Bryda
    Laboratory of Developmental Genetics, Wadsworth Center, New York State Department of Health, Albany 12208, USA
    Genomics 35:425-30. 1996
    ..2 cM distal to D10Mit115 and 0.8 cM proximal to D10Mit173. In addition, five genes, Cdc2a, Col6a1, Col6a2, Bcr, and Ank3 were mapped in both this jcpk intercross and a (BALB/c x CAST/Ei)F1 x BALB/c backcross...
  95. pmc Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments
    S M Jenkins
    Howard Hughes Medical Institute and Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 155:739-46. 2001
    ....
  96. ncbi Essential role of oligodendrocytes in the formation and maintenance of central nervous system nodal regions
    C Mathis
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM CNRS ULP, BP 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Development 128:4881-90. 2001
    ..in the functional segmentation of the axolemma in vivo, the distribution of nodal (Na(+) channels, ankyrin G), paranodal (paranodin/contactin-associated-protein) and juxtaparanodal (Kv1...
  97. ncbi Neurofascin interactions play a critical role in clustering sodium channels, ankyrin G and beta IV spectrin at peripheral nodes of Ranvier
    Darshan Koticha
    W M Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ 08854 8082, USA
    Dev Biol 293:1-12. 2006
    ..NF-Fc significantly inhibited nodal clustering of Na+ channels, ankyrin G, and betaIV spectrin, and modestly reduced Caspr clustering at paranodal junctions; it did not significantly ..
  98. ncbi Cardiac ankyrins: Essential components for development and maintenance of excitable membrane domains in heart
    Shane R Cunha
    Department of Pathology, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Cardiovasc Res 71:22-9. 2006
    ....
  99. pmc Postnatal development of synaptic structure proteins in pyramidal neuron axon initial segments in monkey prefrontal cortex
    Dianne A Cruz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Comp Neurol 514:353-67. 2009
    ....
  100. pmc Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome
    Hanoch Kaphzan
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 31:17637-48. 2011
    ..These findings are the first evidence for pathology of intrinsic membrane properties and AIS-specific changes in AS, a neurodevelopmental disorder associated with autism...

Research Grants18

  1. Peter J Mohler; Fiscal Year: 2016
    ..abstract_text> ..
  2. James Salzer; Fiscal Year: 2016
    ..channels, accessory beta subunits, cell adhesion molecules (CAMs), and a cytoskeletal complex that includes ankyrin G to which channels and CAMs bind. Our recent studies indicate that the node assembles from distinct sources...
  3. THOMAS JEFFREY HUND; Fiscal Year: 2016
    ..5 and cell excitability, and identify novel mechanisms for arrhythmias in both congenital and acquired heart disease. ..
  4. Genomics-Guided Characterization of iPS Cells from Common Mental Illnesses
    Stephen J Haggarty; Fiscal Year: 2012
    ..Similarly, we will use iPS cells from individuals with bipolar disorder associated ankyrin-G (ANK3) haplotypes to determine the effect on basic ion channel physiology, molecular organization of the axon initial ..
  5. Genomics-Guided Characterization of iPS Cells from Common Mental Illnesses
    STEPHEN JOHN HAGGARTY; Fiscal Year: 2010
    ..Similarly, we will use iPS cells from individuals with bipolar disorder associated ankyrin-G (ANK3) haplotypes to determine the effect on basic ion channel physiology, molecular organization of the axon initial ..
  6. Tracey Petryshen; Fiscal Year: 2014
    ..b>Ankyrin 3 (ANK3) is among the strongest and most replicated genes identified by multiple GWAS of BD...
  7. Mario Delmar; Fiscal Year: 2015
    ..abstract_text> ..
  8. Mechanism and function of Kv channel targeting
    Chen Gu; Fiscal Year: 2013
    ..determine whether: (Aim 1) polarized targeting of Kv channels is critical for action potential firing;(Aim 2) ankyrin G at the axon initial segment functions as a conditional barrier for Kv3 splice variants;(Aim 3) protein ..
  9. FGF14 IN THE REGULATION OF PURKINJE NEURON EXCITABILITY AND SCA27
    David M Ornitz; Fiscal Year: 2013
    ..Fgf14-/-mice) anti-FGF14 specific antibody, we find that FGF14 co- localizes with Nav channel 1 subunits at the ankyrin G-rich axon initial segments (AIS) in cerebellar Purkinje neurons, These observations led us to hypothesize that ..
  10. Hemolytic Anemia: Models
    LUANNE PETERS; Fiscal Year: 2006
    ..There are three known Ank genes, Ank1 (erythroid), Ank2 (brain), and Ank3 (general) with overlapping tissue expression but cell type specific localization and binding preferences...
  11. Chay Titus Kuo; Fiscal Year: 2016
    ..We plan to explore this observation by testing the following three hypotheses: 1) the adapter protein Ankyrin 3 plays a critical role in sustaining adult SVZ neurogenesis;2) SVZ ependymal organization serves as specialized ..
  12. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Khadar Abdi; Fiscal Year: 2007
    ..3. Determine the intracellular compartment of mis-targeted IP3-receptor in cardiomyocytes transfected with an ankyrin-B construct harboring a mutation causing loss of interdomain interaction. [unreadable] [unreadable]..
  13. CORTICAL CIRCUITRY AND COGNITION IN SCHIZOPHRENIA
    David Lewis; Fiscal Year: 2007
    ..Our extensive interactions enable us to conduct a translational research program in schizophrenia that effectively transfers information from the clinic to the laboratory and back to the clinic in a truly bidirectional fashion. ..
  14. Synaptic Transmission, Plasticity and Integration in the Subthalamic Nucleus
    Mark D Bevan; Fiscal Year: 2010
    ..abstract_text> ..
  15. SCHIZOPHRENIA AND PREFRONTAL CORTICAL CIRCUITRY
    David Lewis; Fiscal Year: 2004
    ....
  16. CONTROL OF INITIATION OF DNA REPLICATION IN LUNG CANCER
    Edward Johnson; Fiscal Year: 2006
    ..Results will allow identification of links between control of initiation of replication and imposition of checkpoint controls that are critical in preventing progression to cancer...
  17. Proteins Mediating Interaction of HIV-1 and JCV in CNS
    Edward M Johnson; Fiscal Year: 2011
    ..Results will help elucidate pathways of activation of JCV in the brain and will help target particular molecular interactions for therapy. ..
  18. TRANSCRIPTOME OF METASTATIC PROSTATE CANCER
    Gennadi Glinsky; Fiscal Year: 2005
    ..Subsequently the expression profile of these protein products will be studied in human prostate tumor samples by immunofluorescence analysis and immunohistochemistry to better correlate gene expression changes with phenotype. ..