angiopoietin 2

Summary

Gene Symbol: angiopoietin 2
Description: angiopoietin 2
Alias: AGPT2, ANG2, angiopoietin-2, ANG-2, Tie2-ligand, angiopoietin-2B, angiopoietin-2a
Species: human

Top Publications

  1. pmc Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via AP-1 and Ets1
    Feng Chun Ye
    Tumor Virology Program, Children s Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Virol 81:3980-91. 2007
  2. doi Preoperative angiopoietin-2 serum levels: a marker of malignant potential in ovarian neoplasms and poor prognosis in epithelial ovarian cancer
    Hanna Sallinen
    Department of Molecular Medicine, University of Eastern Finland, Department of Gynaecology and Obstetrics, Kuopio University Hospital, Kuopio, Finland
    Int J Gynecol Cancer 20:1498-505. 2010
  3. doi Balance between angiopoietin-1 and angiopoietin-2 is in favor of angiopoietin-2 in atherosclerotic plaques with high microvessel density
    Simone Post
    University Medical Center, Utrecht, The Netherlands
    J Vasc Res 45:244-50. 2008
  4. pmc Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface
    Tania M Hansen
    University of Leicester, Department of Cardiovascular Sciences, RKCSB, PO Box 65, Leicester LE2 7LX, UK
    Cell Signal 22:527-32. 2010
  5. ncbi Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularization
    T Acker
    Department of Neuropathology, Erlangen Nürnberg University Medical School, Erlangen, Germany
    Mech Dev 108:45-57. 2001
  6. doi Angiopoietin-2 expression is correlated with angiogenesis and overall survival in oral squamous cell carcinoma
    Chao Li
    State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No 55, Section 3 Renmin Road South, Chengdu, 610041, Sichuan Province, China
    Med Oncol 30:571. 2013
  7. doi The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1
    Marie Pierre Simon
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, University of Nice, Centre A Lacassagne, Nice, France
    J Cell Physiol 217:809-18. 2008
  8. doi Angiopoietin-2 exocytosis is stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells
    Cholsoon Jang
    National Research Laboratory for Vascular Biology and Department of Biological Sciences, KAIST, Daejeon, Republic of Korea
    Arterioscler Thromb Vasc Biol 29:401-7. 2009
  9. doi Arterial stiffness in hypertensives in relation to expression of angiopoietin-1 and 2 genes in peripheral monocytes
    M E Marketou
    Cardiology Department, Heraklion University Hospital, Crete, Greece
    J Hum Hypertens 24:306-11. 2010
  10. ncbi Plasma concentration of angiopoietin-1, angiopoietin-2 and Tie-2 in cervical cancer
    E Kopczynska
    Department of Pathobiochemistry and Clinical Chemistry, Collegim Medicum, Nicolaus Copernicus University, Torum, Poland
    Eur J Gynaecol Oncol 30:646-9. 2009

Research Grants

  1. Donald M McDonald; Fiscal Year: 2015
  2. Improve Wound Healing with HIF-CA5 DNA Vector and Electroporation
    John W Harmon; Fiscal Year: 2010
  3. Functional role of Angiopoietin-2 in diabetic heart
    Jian xiong Chen; Fiscal Year: 2007
  4. The Angiopoietins in Vascular Maintenance and Remodeling
    Christopher Kontos; Fiscal Year: 2005
  5. Tie2 Regulation and Role in Pathological Angiogenesis
    CLARENCE FINDLEY; Fiscal Year: 2007
  6. Regulation of the Prostate Stem Cell Niche. - Revision - 1
    DAVID A MOSCATELLI; Fiscal Year: 2013
  7. CORONARY BLOOD VESSELS AND HEART DISEASE
    Thomas Sato; Fiscal Year: 2004
  8. Angiopoietins in Prostate Biology and Disease
    David Moscatelli; Fiscal Year: 2005
  9. JOSEPH CHARLES LAMANNA; Fiscal Year: 2014
  10. The Role of Tie2 and the Angiopoietins in EPC Biology
    GREGORY LAM; Fiscal Year: 2006

Detail Information

Publications196 found, 100 shown here

  1. pmc Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via AP-1 and Ets1
    Feng Chun Ye
    Tumor Virology Program, Children s Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Virol 81:3980-91. 2007
    ..b>Angiopoietin 2 (Ang-2) modulates the vasculature during inflammation and angiogenesis, but the mechanism by which KSHV ..
  2. doi Preoperative angiopoietin-2 serum levels: a marker of malignant potential in ovarian neoplasms and poor prognosis in epithelial ovarian cancer
    Hanna Sallinen
    Department of Molecular Medicine, University of Eastern Finland, Department of Gynaecology and Obstetrics, Kuopio University Hospital, Kuopio, Finland
    Int J Gynecol Cancer 20:1498-505. 2010
    ..In addition, we aimed to study how Ang-1 and Ang-2 levels predict the clinical course and survival of patients with epithelial ovarian cancer...
  3. doi Balance between angiopoietin-1 and angiopoietin-2 is in favor of angiopoietin-2 in atherosclerotic plaques with high microvessel density
    Simone Post
    University Medical Center, Utrecht, The Netherlands
    J Vasc Res 45:244-50. 2008
    ..Ang-1 induces formation of stable vessels, whereas Ang-2 destabilizes the interaction between endothelial cells and their support cells. We studied the expression patterns of Ang-1 and -2 in relation to plaque microvessels...
  4. pmc Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface
    Tania M Hansen
    University of Leicester, Department of Cardiovascular Sciences, RKCSB, PO Box 65, Leicester LE2 7LX, UK
    Cell Signal 22:527-32. 2010
    Angiopoietin-1 (Ang1) and Ang2 are ligands for the receptor tyrosine kinase Tie2. Structural data suggest that the two ligands bind Tie2 similarly...
  5. ncbi Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularization
    T Acker
    Department of Neuropathology, Erlangen Nürnberg University Medical School, Erlangen, Germany
    Mech Dev 108:45-57. 2001
    ..VEGF and Ang-1/2 expression patterns shifted in a similar inside-out fashion, supporting their proposed function in vessel growth and maturation...
  6. doi Angiopoietin-2 expression is correlated with angiogenesis and overall survival in oral squamous cell carcinoma
    Chao Li
    State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No 55, Section 3 Renmin Road South, Chengdu, 610041, Sichuan Province, China
    Med Oncol 30:571. 2013
    ..Expression of Ang-2 was associated with angiogenesis and vessel maturation in OSCC. Further studies will evaluate the prognostic value of determining Ang-2 expression in OSCC...
  7. doi The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1
    Marie Pierre Simon
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, University of Nice, Centre A Lacassagne, Nice, France
    J Cell Physiol 217:809-18. 2008
    ..In conclusion, our study provides new elements in favor of HIF involvement in Ang-2 hypoxic regulation and identifies Ets-1 and particularly GATA-2 as central factors in endothelial specific Ang-2 expression...
  8. doi Angiopoietin-2 exocytosis is stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells
    Cholsoon Jang
    National Research Laboratory for Vascular Biology and Department of Biological Sciences, KAIST, Daejeon, Republic of Korea
    Arterioscler Thromb Vasc Biol 29:401-7. 2009
    Although diverse functions of angiopoietin-2 (Ang2) have been revealed, little is known about upstream signaling molecules regulating Ang2 exocytosis...
  9. doi Arterial stiffness in hypertensives in relation to expression of angiopoietin-1 and 2 genes in peripheral monocytes
    M E Marketou
    Cardiology Department, Heraklion University Hospital, Crete, Greece
    J Hum Hypertens 24:306-11. 2010
    ..This positive correlation may suggest a link between angiogenesis and arterial stiffness in those patients...
  10. ncbi Plasma concentration of angiopoietin-1, angiopoietin-2 and Tie-2 in cervical cancer
    E Kopczynska
    Department of Pathobiochemistry and Clinical Chemistry, Collegim Medicum, Nicolaus Copernicus University, Torum, Poland
    Eur J Gynaecol Oncol 30:646-9. 2009
    ..Overexpression of angiopoietins has been observed in various tumors. The aim of the study was to evaluate plasma concentration of Ang-1, Ang-2 and Tie-2 in cervical cancer...
  11. doi Angiopoietin-1 and -2 exert antagonistic functions in tumor angiogenesis, yet both induce lymphangiogenesis
    Ernesta Fagiani
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    Cancer Res 71:5717-27. 2011
    ..The poor perfusion of immature blood vessels results in retarded tumor growth, defining an important pathophysiologic pathway required for efficient tumorigenesis...
  12. ncbi Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region
    Y Xu
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:34990-8. 2001
    ..Implications of the difference in the ECM association of Ang-1 and Ang-2, which are related to the regulation of angiopoietin activity and their roles in local versus distant angiogenesis during tumor metastasis, are discussed...
  13. pmc Inhibition of angiopoietin-2 in LuCaP 23.1 prostate cancer tumors decreases tumor growth and viability
    Colm Morrissey
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    Prostate 70:1799-808. 2010
    ..Therefore, we hypothesized that the inhibition of angiopoietin-2 activity in PCa will impede angiogenesis, tumor growth, and alter bone response in vivo...
  14. pmc Angiopoietin-1 treatment reduces inflammation but does not prevent ventilator-induced lung injury
    Maria A Hegeman
    Laboratory of Neuroimmunology and Developmental Origins of Disease, Department of Pediatric Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 5:e15653. 2010
    ..Moreover, we evaluated whether treatment with Ang-1, a Tie2 receptor agonist, protects against inflammation, vascular leakage and impaired gas exchange induced by mechanical ventilation...
  15. ncbi Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats
    Ulrike Fiedler
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, 79106 Freiburg, Germany
    J Biol Chem 278:1721-7. 2003
    ....
  16. ncbi Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significance
    Di Tang
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita 565 0871, Osaka, Japan
    Oncol Rep 15:525-32. 2006
    ..Although TSP-1 may increase intrahepatic CCC metastases, neither MVD levels nor the expression of VEGF, Ang-1, or Ang-2 was associated with clinicopathological factors and prognosis...
  17. ncbi Transcriptional regulation of human angiopoietin-2 by transcription factor Ets-1
    Yasuhiro Hasegawa
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 316:52-8. 2004
    ..Moreover, synthetic double-strand oligonucleotides containing corresponding EBS8 abrogated the induction of Ang-2 by VEGF in HUVECs. These results indicate that Ets-1 and the corresponding EBS are critical for the induction of Ang-2...
  18. pmc Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 gamma 2 correlates with the invasiveness of human glioma
    Ping Guo
    Department of Pathology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 1863, USA
    Am J Pathol 166:877-90. 2005
    ..We recently showed that angiopoietin-2 (Ang2) induces glioma invasion through the activation of matrix metalloprotease-2 (MMP-2)...
  19. ncbi Expression pattern of angiogenic factors and prognosis after hepatic resection in hepatocellular carcinoma: importance of angiopoietin-2 and hypoxia-induced factor-1 alpha
    Hiroshi Wada
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Liver Int 26:414-23. 2006
    ..Angiogenesis is regulated by a balance between pro and antiangiogenic molecules. The aim of this study was to investigate the expressions of angiogenic factors and elucidate their roles in angiogenesis in HCC...
  20. ncbi Regulation of Foxo-1 and the angiopoietin-2/Tie2 system by shear stress
    Sven Chlench
    Charite, Campus Benjamin Franklin, Institute of Physiology, Arnimallee 22, 14195 Berlin, Germany
    FEBS Lett 581:673-80. 2007
    ..eNOS and Tie2 were upregulated. No effects on Ang-1 expression were detected. In conclusion, Foxo-1 and Ang-2/Tie2 are part of the molecular response to shear stress, which may regulate angiogenesis...
  21. pmc Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2
    Vicky P K H Nguyen
    Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    BMC Cell Biol 8:10. 2007
    ..Angiopoietins 1 and 2 (Ang1 and Ang2) are regulators of both angiogenesis and lymphangiogenesis through the Tek/Tie-2 receptor tyrosine kinase...
  22. ncbi Elevated serum sFlt-1/Ang-2 ratio in women with preeclampsia
    Kumiko Hirokoshi
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Nephron Clin Pract 106:c43-50. 2007
    ....
  23. ncbi Release of angiopoietin-1 by primary human acute myelogenous leukemia cells is associated with mutations of nucleophosmin, increased by bone marrow stromal cells and possibly antagonized by high systemic angiopoietin-2 levels
    K J Hatfield
    Section of Hematology, Institute of Medicine, University of Bergen, Bergen, Norway
    Leukemia 22:287-93. 2008
    ..Local Ang-2 release from AML cells is less common, but high systemic levels of Ang-2 may affect bone marrow angioregulation...
  24. ncbi Hypoxic regulation of angiopoietin-2 expression in endothelial cells
    Paola Pichiule
    Department of Anatomy, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Biol Chem 279:12171-80. 2004
    Exposure of endothelial cells to hypoxia-induced angiopoietin-2 (Ang2) expression. The increase in Ang2 mRNA levels occurred by transcriptional regulation and by post-transcriptional increase in mRNA stability...
  25. ncbi Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses
    Caroline Lemieux
    Research Center, Montreal Heart Institute, Montreal, QC, Canada H1T 1C8
    Blood 105:1523-30. 2005
    Angiopoietin-1 (Ang1) and -2 (Ang2) are endothelial growth factors that bind to the tyrosine kinase receptor Tie2 and contribute to orchestrate blood vessel formation during angiogenesis...
  26. ncbi Plasma vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in diabetes: implications for cardiovascular risk and effects of multifactorial intervention
    Hoong Sern Lim
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, B18 7QH, UK
    Diabetes Care 27:2918-24. 2004
    ....
  27. ncbi Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2
    Kyung Tae Kim
    Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon
    J Biol Chem 280:20126-31. 2005
    ..In this study, we generated several Ang1 and angiopoietin-2 (Ang2) variants to define the role of the superclustering and oligomerization domains of the Ang1 protein...
  28. pmc Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway
    Bo Hu
    University of Pittsburgh Cancer Institute, Research Pavilion at the Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Cancer Res 66:775-83. 2006
    Accumulating evidence reveals a significant correlation between angiopoietin 2 (Ang2) expression and tumor invasion and metastasis in various human cancers, but the major focus of recent studies has been on the angiogenic effects of Ang2...
  29. pmc Expression of angiopoietin 1, 2 and their common receptor Tie2 in human gastric carcinoma: implication for angiogenesis
    Woo Sung Moon
    Department of Pathology, Chonbuk National University, Medical School, Institute for Medical Sciences and Center for Healthcare Technology Development, Dukjin Gu, Jeonju, Korea
    J Korean Med Sci 21:272-8. 2006
    ..001, respectively). These findings indicate that the expression of Ang-1 and Ang-2 is important for tumor angiogenesis, and suggest a possible role of autocrine/paracrine function of angiopoietin/Tie2 system in gastric cancer progression...
  30. ncbi Impaired pericyte recruitment and abnormal retinal angiogenesis as a result of angiopoietin-2 overexpression
    Yuxi Feng
    5th Medical Clinic, Faculty of Clinical Medicine, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Thromb Haemost 97:99-108. 2007
    Angiopoietin-2 (Ang2) is among the relevant growth factors induced by hypoxia and plays an important role in the initiation of retinal neovascularizations...
  31. pmc Admission angiopoietin levels in children with septic shock
    John S Giuliano
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Shock 28:650-654. 2007
    ..Given the contrasting effects of angpt-2 and angpt-1 on the vascular endothelium, these two factors may play an important role in the pathophysiology of septic shock in children, and further studies are warranted...
  32. doi Kinetics of angiopoietin-2 in serum of multi-trauma patients: correlation with patient severity
    Evangelos J Giamarellos-Bourboulis
    4th Department of Internal Medicine, Attikon University General Hospital, University of Athens, Medical School, 1 Rimini Street, 124 62 Athens, Greece
    Cytokine 44:310-3. 2008
    ..Angiopoietin-2 (Ang-2) is considered a proinflammatory mediator promoting vascular leakage. Its participation in the inflammatory process following multiple injuries was investigated...
  33. doi Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma
    Iris Helfrich
    Joint Research Division of Vascular Biology, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 15:1384-92. 2009
    The blood vessel-destabilizing Tie2 ligand angiopoietin-2 (Ang-2) acts in concert with the vascular endothelial growth factor/vascular endothelial growth factor receptor system to control vessel assembly during tumor progression...
  34. doi Circulating angiopoietin-2 is elevated in patients with neuroendocrine tumours and correlates with disease burden and prognosis
    R Srirajaskanthan
    Neuroendocrine Tumour Unit, Royal Free Hospital, London NW3 2QG, UK
    Endocr Relat Cancer 16:967-76. 2009
    ..04). Serum Ang-2 but not Ang-1 is elevated in NET patients. Ang-2 may be a useful serum marker for monitoring and assessment of prognosis in patients with NETs...
  35. pmc Dysregulation of angiopoietins is associated with placental malaria and low birth weight
    Karlee L Silver
    McLaughlin Rotman Centre for Global Health, University Health Network, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 5:e9481. 2010
    ..Based on the essential role of angiopoietin (ANG)-1 and -2 in normal placental vascular development, we hypothesized that PM may result in the dysregulation of angiopoietins and thereby contribute to LBW outcomes...
  36. ncbi Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    P C Maisonpierre
    Regeneron Pharmaceuticals Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Science 277:55-60. 1997
    ..An Ang1 relative, termed angiopoietin-2 (Ang2), was identified by homology screening and shown to be a naturally occurring antagonist for Ang1 and Tie2...
  37. ncbi Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2
    B Witzenbichler
    Department of Cardiovascular Research, St Elizabeth s Medical Center of Boston, Tufts University School of Medicine, Boston, MA 02135, USA
    J Biol Chem 273:18514-21. 1998
    ....
  38. pmc Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma
    S Tanaka
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
    J Clin Invest 103:341-5. 1999
    ..The full coding sequence of a variant angiopoietin-2 (Ang2) cDNA was obtained from HCC specimens, and the biologic consequences of overexpression on tumor formation and ..
  39. ncbi Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity
    W N Procopio
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6142, USA
    J Biol Chem 274:30196-201. 1999
    ....
  40. ncbi Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells
    Yao Qi Huang
    Department of Medicine and Kaplan Cancer Center, New York University Medical School, New York, NY 10016, USA
    Blood 99:1646-50. 2002
    ..Thus, thrombin-induced tumorigenesis and metastasis is associated with enhanced Ang-2 protein synthesis and secretion via enhanced transcription of Ang-2. This could help explain how thrombin promotes angiogenesis...
  41. ncbi Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2
    Eli Geva
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143 0556, USA
    J Clin Endocrinol Metab 87:4213-24. 2002
    ..5 (not significant) and 2.8%/wk (P = 0.034), respectively, whereas Ang2 decreased logarithmically by 3.5%/wk (P = 0.0003)...
  42. ncbi Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma
    Noboru Mitsuhashi
    Department of General Surgery, Graduate School of Medicine, Chiba University, Japan
    Hepatology 37:1105-13. 2003
    ..In conclusion, an increased expression of Ang-2/1 in the presence of VEGF may play a critical role in promoting tumor angiogenesis and progression in human HCC...
  43. ncbi Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer
    Lin Zhang
    Abramson Family Cancer Research Institute, Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 63:3403-12. 2003
    ....
  44. ncbi Human cytotrophoblasts promote endothelial survival and vascular remodeling through secretion of Ang2, PlGF, and VEGF-C
    Yan Zhou
    Department of Stomatology, University of California San Francisco, San Francisco, CA 94143, USA
    Dev Biol 263:114-25. 2003
    ..The data show that cytotrophoblasts predominantly expressed Ang2. We also studied the paracrine functions of Ang2 and the VEGFs by culturing uterine microvascular endothelial cells ..
  45. ncbi The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies
    Ulrike Fiedler
    Department of Vascular Biology and Angiogenesis Research Tumor Biology Center, Breisacher Str 117, 79106 Freiburg, Germany
    Blood 103:4150-6. 2004
    ....
  46. ncbi Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma
    Takuji Torimura
    Second Department of Medicine, Kurume University School of Medicine, Liver Cancer Division, Research Center for Innovative Cancer Therapy, and Center of the 21st Century COE Program for Medical Science, Kurume University, Fukuoka 830 0011, Japan
    J Hepatol 40:799-807. 2004
    ..Hepatocellular carcinoma (HCC) is a highly vascular tumor. Angiopoietin-1 and Angiopoietin-2 have been shown to be involved in tumor angiogenesis. We investigated the expression of Angiopoietin-1 and Angiopoietin-2 in HCC...
  47. ncbi Expression of angiopoietin-2 in endothelial cells is controlled by positive and negative regulatory promoter elements
    Anja Hegen
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, D 79106 Freiburg, Germany
    Arterioscler Thromb Vasc Biol 24:1803-9. 2004
    ..To examine the transcriptional regulation of Ang-2, we studied the Ang-2 promoter in endothelial cells and nonendothelial cells...
  48. ncbi Biological characterization of angiopoietin-3 and angiopoietin-4
    Hyuek Jong Lee
    Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    FASEB J 18:1200-8. 2004
    The angiopoietin (Ang) family of growth factors includes Ang1, Ang2, Ang3, and Ang4, all of which bind to the endothelial receptor tyrosine kinase Tie2. Ang3 (mouse) and Ang4 (human) are interspecies orthologs...
  49. ncbi Overexpression of Ang-2 mRNA in non-small cell lung cancer: association with angiogenesis and poor prognosis
    Iwao Takanami
    Department of Surgery, Teikyo University School of Medicine, Tokyo 173, Japan
    Oncol Rep 12:849-53. 2004
    ..0028). These data indicate that Ang-2 may contribute to tumor angiogenesis and progression and that Ang-2 gene expression can serve as a useful prognostic marker in NSCLC...
  50. ncbi Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition
    William A Barton
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Structure 13:825-32. 2005
    ..4 A crystal structure of the Angiopoietin-2 (Ang2) receptor binding region. The structure reveals a fibrinogen fold with a unique C-terminal P domain...
  51. ncbi Increase of serum angiopoietin-2 during pregnancy is suppressed in women with preeclampsia
    Kumiko Hirokoshi
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Am J Hypertens 18:1181-8. 2005
    ....
  52. pmc Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans
    Samir M Parikh
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 3:e46. 2006
    ..We hypothesized that Ang-2 contributes to endothelial barrier disruption in sepsis-associated lung injury, a condition involving the mature vasculature...
  53. ncbi Angiopoietin 2 expression in invasive ductal carcinoma of the breast: its relationship to the VEGF expression and microvessel density
    Shinichi Tsutsui
    Department of Breast Surgery, Matsuyama Red Cross Hospital, Matsuyama, Japan
    Breast Cancer Res Treat 98:261-6. 2006
    ..The survival analysis demonstrated a high MVD, which was induced by a high expression of both VEGF and Ang-2, to therefore have a strong prognostic significance in breast cancer...
  54. ncbi Signaling and regulation of endothelial cell survival by angiopoietin-2
    Rania Harfouche
    Rm L3 05, Critical Care Division, Royal Victoria Hospital, 687 Pine Ave West, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 291:H1635-45. 2006
    ..We also conclude that the nature of interactions in terms of ERK1/2 activation between Ang-2 and VEGF is different from that of Ang-1 and VEGF...
  55. ncbi Expression of angiopoietins and their receptor Tie2 in the bone marrow of patients with acute myeloid leukemia
    Christoph Schliemann
    Department of Medicine Hematology and Oncology, and the IZKF Muenster, University of Muenster, Albert Schweitzer Strasse 33, D 48129 Muenster, Germany
    Haematologica 91:1203-11. 2006
    ..Angiopoietin-1 (Ang-1) and its natural antagonist angiopoietin-2 (Ang-2), both ligands for the receptor tyrosine kinase Tie2, are known to play an essential role in normal and pathological angiogenesis...
  56. pmc Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells
    Christopher Daly
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 103:15491-6. 2006
    ..Our data suggests a model in which Ang-2 expression is induced in stressed endothelial cells, where it acts as an autocrine Tie2 agonist and protective factor...
  57. ncbi Serum angiopoietin-2 as a clinical marker for lung cancer
    Joo Hun Park
    Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, San 5, Wonchon dong, Yeongtong Gu, Suwon, Gyeonggi do 443 721, South Korea
    Chest 132:200-6. 2007
    ..Angiopoietins play a critical role in the angiogenesis related to tumor growth in concert with vascular endothelial growth factor (VEGF), and enhanced expression of angiopoietin-2 has been reported in lung cancer tissue...
  58. ncbi Expression of Tie-2 by human monocytes and their responses to angiopoietin-2
    Craig Murdoch
    Tumor Targeting Group, Academic Unit of Pathology, Division of Genomic Medicine, The Sir Henry Wellcome Laboratories for Medical Research, University of Sheffield Medical School, Sheffield, United Kingdom
    J Immunol 178:7405-11. 2007
    ..In sum, our data indicate that Ang-2 may recruit Tie-2(+) monocytes to tumors and sites of inflammation, modulate their release of important cytokines and stimulate them to express a proangiogenic phenotype...
  59. ncbi Expression of angiopoietins and vascular endothelial growth factors and their clinical significance in acute myeloid leukemia
    Hsin An Hou
    Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Leuk Res 32:904-12. 2008
    ..Subgroup analysis showed that Ang-2 expression had prognostic impact on patients with low (but not high) Ang-1 or Tie2 levels, and on patients with high (but not low) VEGF-A or VEGF-C levels...
  60. doi Regulation of angiopoietin expression by bacterial lipopolysaccharide
    Mahroo Mofarrahi
    Critical Care Division, Royal Victoria Hospital, 687 Pine Ave West, Montreal, Quebec, Canada H3A 1A1
    Am J Physiol Lung Cell Mol Physiol 294:L955-63. 2008
    ....
  61. doi Angiopoietin-2 levels as a biomarker of cardiovascular risk in patients with hypertension
    Jeetesh V Patel
    University Department of Medicine, City Hospital, Birmingham, UK
    Ann Med 40:215-22. 2008
    ..We hypothesized that raised levels of angiopoietin (Ang)-1 and -2 would predict events in patients with hypertension treated for CVD...
  62. pmc Plasma angiopoietin-2 levels increase in children following cardiopulmonary bypass
    John S Giuliano
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Intensive Care Med 34:1851-7. 2008
    ..The aim was to investigate the effects of cardiopulmonary bypass (CPB) on plasma levels of the vascular growth factors, angiopoietin (angpt)-1, angpt-2, and vascular endothelial growth factor (VEGF)...
  63. pmc Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays
    Alexander Lukasz
    Department of Nephrology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Crit Care 12:R94. 2008
    ..The use of circulating Ang-1 and Ang-2 as novel biomarkers of endothelial integrity has therefore gained much attention. The preclinical characteristics and clinical applicability of angiopoietin immunoassays, however, remain elusive...
  64. doi The distribution of angiopoietin-1, angiopoietin-2 and their receptors tie-1 and tie-2 in the very early human placenta
    Y Seval
    Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey
    Placenta 29:809-15. 2008
    ....
  65. doi Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis
    Jonathan M Siner
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    Shock 31:348-53. 2009
    The vascular growth factor angiopoietin 2 (Ang-2) is known to promote inflammation and endothelial dysfunction, but its prognostic capacity and relationship to outcomes in human sepsis are unknown...
  66. pmc Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin NT 0810, Australia
    Proc Natl Acad Sci U S A 105:17097-102. 2008
    ..Agents that improve endothelial NO, reduce WPB exocytosis, and/or antagonize Ang-2 may have therapeutic roles in SM...
  67. doi The angiopoietin 1/angiopoietin 2 balance as a prognostic marker in primary glioblastoma multiforme
    Mariska Sie
    Department of Pediatrics, Pediatric Oncology Division, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, The Netherlands
    J Neurosurg 110:147-55. 2009
    ..In the present study, the authors analyzed the ANGPT1/ANGPT2 balance in the context of therapeutic outcome in 62 patients with primary glioblastomas multiforme (GBMs)...
  68. doi Localization of angiogenic growth factors and their receptors in the human placental bed throughout normal human pregnancy
    B Schiessl
    School of Surgical and Reproductive Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Placenta 30:79-87. 2009
    ..These findings suggest that the Ang and VEGF families may play a role in the process of spiral artery remodelling in normal pregnancy...
  69. pmc Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium
    Hai Tao Yuan
    Molecular and Vascular Medicine, Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 29:2011-22. 2009
    b>Angiopoietin 2 (Ang2) was originally shown to be a competitive antagonist for Ang1 of the receptor tyrosine kinase Tie2 in endothelial cells (ECs). Since then, reports have conflicted on whether Ang2 is an agonist or antagonist of Tie2...
  70. pmc Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children
    Fiona E Lovegrove
    McLaughlin Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 4:e4912. 2009
    ..The objective of this study was to assess serum biomarkers that differentiate between CM and non-CM, with the long-term goal of developing a clinically informative prognostic test for severe malaria...
  71. doi Angiopoietin-2 is increased in septic shock: evidence for the existence of a circulating factor stimulating its release from human monocytes
    Hariklia Kranidioti
    4th Department of Internal Medicine, University of Athens, Medical School, Greece
    Immunol Lett 125:65-71. 2009
    ..It seems that a circulating factor may exist in the serum of patients with septic shock that stimulates gene expression and subsequent release of Ang-2 from monocytes. TLR4 and TNFalpha modulate release of Ang-2...
  72. pmc Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality
    Melanie van der Heijden
    Department of Intensive Care, VU University Medical Centre, Amsterdam, The Netherlands
    Intensive Care Med 35:1567-74. 2009
    ....
  73. pmc Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels
    Beverly L Falcon
    Cardiovascular Research Institute, University of California, San Francisco, USA
    Am J Pathol 175:2159-70. 2009
    Angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) have complex actions in angiogenesis and vascular remodeling due to their effects on Tie2 receptor signaling...
  74. doi Angiopoietin-2 levels in glucose intolerance, hypertension, and metabolic syndrome in Asian Indians (Chennai Urban Rural Epidemiology Study-74)
    Sathish Anuradha
    Madras Diabetes Research Foundation and Dr Mohan s Diabetes Specialities Centre, WHO Collaborating Centre for Non communicable Diseases Prevention and Control, Gopalapuram, Chennai 600086, India
    Metabolism 59:774-9. 2010
    ..001). This study demonstrates that increased levels of Ang-2 are seen in Asian Indian subjects with IGT, T2DM, and hypertension and in subjects with MS even in the absence of fasting hyperglycemia...
  75. doi Angiopoietin-2 promotes disease progression of neuroendocrine tumors
    Katharina M Detjen
    Medizinische Klinik m S Hepatologie und Gastroenterologie, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin, Germany
    Clin Cancer Res 16:420-9. 2010
    ..We therefore addressed the expression and biological significance of Ang-2 in human neuroendocrine tumors...
  76. doi Circulating angiopoietin-2 levels increase with progress of chronic kidney disease
    Sascha David
    Division of Nephrology and Hypertension, Medical School Hannover, Hannover, Germany
    Nephrol Dial Transplant 25:2571-6. 2010
    ..In addition, we aimed to detect a potential link between the nitric oxide (NO) synthase inhibitor asymmetric dimethylarginine (ADMA) and the Ang-2 levels...
  77. pmc Clinical and genetic correlates of circulating angiopoietin-2 and soluble Tie-2 in the community
    Wolfgang Lieb
    Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circ Cardiovasc Genet 3:300-6. 2010
    ..The clinical and genetic correlates of circulating angiopoietin-2 (Ang-2) and its soluble receptor/regulator Tie-2 (sTie-2) have not been determined in a community-based sample...
  78. pmc Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity
    Joshua S Davis
    International Health Division, Menzies School of Health Research and Charles Darwin University, Ellengowan Drive, Casuarina, Darwin, NT 0810, Australia
    Crit Care 14:R89. 2010
    ..Nitric oxide (NO) inhibits WPB exocytosis, and bioavailability of endothelial NO is decreased in sepsis. We hypothesized that endothelial NO bioavailability would be inversely correlated with ang-2 concentrations in sepsis...
  79. pmc Angiopoietin-2 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradation
    Markus Thomas
    Joint Research Division Vascular Biology, Medical Faculty Mannheim CBTM, Heidelberg University, D 69120 Heidelberg, Germany
    J Biol Chem 285:23842-9. 2010
    ..Taken together, the experiments define Tie2/alphavbeta3 integrin association-induced integrin internalization and degradation as mechanistic consequences of endothelial Ang-2 stimulation...
  80. doi Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage
    Young Jun Koh
    Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Cancer Cell 18:171-84. 2010
    ..Thus, simultaneous blockade of VEGF-A and angiopoietins with DAAP is an effective therapeutic strategy for blocking tumor angiogenesis, metastasis, and vascular leakage...
  81. pmc Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer
    E Volkova
    Angiogenesis and Cancer Research Group, Department of Pathology, University of Otago Christchurch, PO Box 4345, Christchurch 8140, New Zealand
    Br J Cancer 104:51-9. 2011
    ..This study investigated the relationship of obesity, insulin resistance, inflammation and angiogenesis with cancer progression and survival in a colorectal cancer cohort...
  82. pmc ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio
    Nuala J Meyer
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 183:1344-53. 2011
    ..Acute lung injury (ALI) acts as a complex genetic trait, yet its genetic risk factors remain incompletely understood. Large-scale genotyping has not previously been reported for ALI...
  83. doi Stepwise increase of angiopoietin-2 serum levels is related to haemodynamic and functional impairment in stable chronic heart failure
    Ermanno Eleuteri
    Divisione di Cardiologia Riabilitativa, Fondazione Salvatore Maugeri, IRCCS, Istituto Scientifico di Veruno, Veruno NO, Italy
    Eur J Cardiovasc Prev Rehabil 18:607-14. 2011
    ..Our aim was to investigate whether there are detectable signs of ongoing angiogenesis in serum of CHF patients and to evaluate the correlation with indexes of haemodynamic and functional impairment...
  84. pmc Prognostic impacts of angiopoietins in NSCLC tumor cells and stroma: VEGF-A impact is strongly associated with Ang-2
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    PLoS ONE 6:e19773. 2011
    ..This study evaluates the prognostic impact of all known human angiopoietins (Ang-1, Ang-2 and Ang-4) and their receptor Tie-2, as well as their relation to the prognostic expression of VEGF-A...
  85. pmc Circulating angiopoietins-1 and -2, angiopoietin receptor Tie-2 and vascular endothelial growth factor-A as biomarkers of acute myocardial infarction: a prospective nested case-control study
    Carlos Iribarren
    Kaiser Permanente Division of Research, Oakland, CA 94612, USA
    BMC Cardiovasc Disord 11:31. 2011
    ..Our aim was to examine the association between circulating levels of markers of angiogenesis with risk of incident acute myocardial infarction (AMI) in men and women...
  86. doi A human neutralizing antibody specific to Ang-2 inhibits ocular angiogenesis
    Emma S Rennel
    Microvascular Research Laboratories, Bristol Heart Institute, School of Physiology and Pharmacology, Veterinary Sciences Building, University of Bristol, Bristol, UK
    Microcirculation 18:598-607. 2011
    ..a critical contributor to ocular as well as neoplastic diseases, is stimulated by endothelial production of angiopoietin-2 (Ang2). Our objective was to determine the requirement of ocular angiogenesis for Ang2 in animal models of disease.
  87. pmc Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling
    Moritz Felcht
    Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg DKFZ ZMBH Alliance, Heidelberg, Germany
    J Clin Invest 122:1991-2005. 2012
    ..The results of this study have immediate translational implications for the therapeutic exploitation of angiopoietin signaling...
  88. doi Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis
    Sarah Krausz
    Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
    Ann Rheum Dis 71:1402-10. 2012
    ....
  89. pmc Imbalance of angiopoietin-1 and angiopoetin-2 in severe dengue and relationship with thrombocytopenia, endothelial activation, and vascular stability
    Meta Michels
    Department of General Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
    Am J Trop Med Hyg 87:943-6. 2012
    ..Dengue-associated thrombocytopenia and endothelial activation are associated with an imbalance in angiopoietin-2: angiopoietin-1 plasma levels. This imbalance may contribute to the transient plasma leakage in DHF/DSS...
  90. doi Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition
    Christopher Daly
    Regeneron Pharmaceuticals, Inc, Tarrytown, NY, USA
    Cancer Res 73:108-18. 2013
    The angiopoietins Ang1 (ANGPT1) and Ang2 (ANGPT2) are secreted factors that bind to the endothelial cell-specific receptor tyrosine kinase Tie2 (TEK) and regulate angiogenesis...
  91. doi Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy
    Damien Gerald
    ImClone Systems, New York, New York 10016, USA
    Cancer Res 73:1649-57. 2013
    ..Angiopoietin-2 (Ang2) appears to be a particularly attractive therapeutic target...
  92. doi Angiogenic axis angiopoietin-1 and angiopoietin-2/Tie-2 in non-small cell lung cancer: a bronchoalveolar lavage and serum study
    W Naumnik
    Department of Lung Diseases, Medical University of Bialystok, 14 Zurawia St, 15 540, Bialystok, Poland
    Adv Exp Med Biol 788:341-8. 2013
    ..We conclude that the angiogenic axis Ang-1 and Ang-2/Tie-2 may play an important role in lung cancer development and their concentrations may be a useful marker at the time of initial diagnosis of lung cancer. ..
  93. ncbi Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2
    Jonathan Oliner
    Amgen, Thousand Oaks, California 91320, USA
    Cancer Cell 6:507-16. 2004
    Angiopoietin-2 (Ang2) exhibits broad expression in the remodeling vasculature of human tumors but very limited expression in normal tissues, making it an attractive candidate target for antiangiogenic cancer therapy...
  94. ncbi Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer
    Kohkichi Hata
    Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan
    Oncology 62:340-8. 2002
    The recent discovery of angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) has provided novel and important insights into the molecular mechanisms of blood vessel formation...
  95. ncbi Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma
    Takehiko Ochiumi
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biochemical Research, Graduated School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Int J Oncol 24:539-47. 2004
    ....
  96. ncbi Angiopoietin-1 and angiopoietin-2 in diabetes mellitus: relationship to VEGF, glycaemic control, endothelial damage/dysfunction and atherosclerosis
    Hoong Sern Lim
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Atherosclerosis 180:113-8. 2005
    ..We hypothesised increased angiopoietins (Ang)-1 and -2 in patients with diabetes that are related to VEGF, medium-term glycaemic control, endothelial damage/dysfunction and atherosclerosis...
  97. pmc Expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumor, leiomyoma and schwannoma
    Toshiyuki Nakayama
    Department of Tumor and Diagnostic Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki, Japan
    World J Gastroenterol 13:4473-9. 2007
    ..To investigate the role of angiopoietin (Ang) -1, -2 and -4 and its receptors, Tie-1 and -2, in the growth and differentiation of gastrointestinal stromal tumors (GISTs)...
  98. doi Angiopoietin-2 predicts disease-free survival after allogeneic stem cell transplantation in patients with high-risk myeloid malignancies
    Philipp Kümpers
    Center for Internal Medicine, Hannover Medical School, Hannover, Germany
    Blood 112:2139-48. 2008
    ..Because few predictors for DFS exist in the setting of allo-HSCT, Ang-2 may be used as a readily available powerful biomarker to pre-estimate DFS and may open new perspectives for risk-adapted treatment of high-risk myeloid malignancies...
  99. ncbi Autocrine/paracrine role of the angiopoietin-1 and -2/Tie2 system in cell proliferation and chemotaxis of cultured fibroblastic synoviocytes in rheumatoid arthritis
    Kazuhiro Takahara
    Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Japan
    Hum Pathol 35:150-8. 2004
    ..study used immunohistochemistry and in situ hybridization to examine whether angiopoietin-1 and -2 (Ang1 and Ang2), ligands for Tie2, are also expressed in the RA synovium...
  100. pmc Preeclampsia and small-for-gestational age are associated with decreased concentrations of a factor involved in angiogenesis: soluble Tie-2
    Francesca Gotsch
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 21:389-402. 2008
    ..The purpose of this study was to determine whether patients with preeclampsia and mothers who deliver a SGA neonate have changes in the plasma concentrations of sTie-2...
  101. ncbi Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization
    T Asahara
    Department of Medicine Cardiology, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circ Res 83:233-40. 1998
    ..Angiopoietin-2 (Ang2) was found to disrupt blood vessel formation in the developing embryo by antagonizing the effects of Ang1 and Tie2 ..

Research Grants69

  1. Donald M McDonald; Fiscal Year: 2015
    ..vessels and lymphatics: angiopoietin-1 (Ang1) activates Tie2 receptors on endothelial cells, and angiopoietin-2 (Ang2) inhibits or activates Tie2 signaling, depending on context and temporal-spatial concentrations...
  2. Improve Wound Healing with HIF-CA5 DNA Vector and Electroporation
    John W Harmon; Fiscal Year: 2010
    ..of mRNA expression for important angiogenic peptides including VEGF, PLGF, PDGF-B, Angiopoietin 1 and Angiopoietin 2. Pre-clinical testing in diabetic mice with excisional wounds has demonstrated that EP mediated delivery of ..
  3. Functional role of Angiopoietin-2 in diabetic heart
    Jian xiong Chen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  4. The Angiopoietins in Vascular Maintenance and Remodeling
    Christopher Kontos; Fiscal Year: 2005
    ..Angiopoietin-1 (Ang1) is an activating ligand while Angiopoietin-2 (Ang2) is thought to be a naturally occurring antagonist for Tie2...
  5. Tie2 Regulation and Role in Pathological Angiogenesis
    CLARENCE FINDLEY; Fiscal Year: 2007
    ..of Tie2 signaling and [unreadable] function is complex, as its ligands, Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2), have opposing effects on the vasculature...
  6. Regulation of the Prostate Stem Cell Niche. - Revision - 1
    DAVID A MOSCATELLI; Fiscal Year: 2013
    ..The experiments will provide novel information on the role of endothelial cells in the prostate stem cell niche that will also be relevant to the prostate tumor stem cell niche. ..
  7. CORONARY BLOOD VESSELS AND HEART DISEASE
    Thomas Sato; Fiscal Year: 2004
    ..This information may potentially have a future impact on how to enhance the maturation of the physiological functionality of these vessels, a goal where therapies based on angiogenesis alone may fall short. ..
  8. Angiopoietins in Prostate Biology and Disease
    David Moscatelli; Fiscal Year: 2005
    ..Identification of angiopoietin-1 or angiopoietin-2 as a key mediator of angiogenesis in the prostate may lead to new treatment strategies for both androgen-sensitive and androgen- independent prostate tumors. ..
  9. JOSEPH CHARLES LAMANNA; Fiscal Year: 2014
    ..The specific aims are organized to elucidate the role of neuronal HIF-1, astrocytic HIF-2, and endothelial COX-2 in angiogenesis and, in addition, the role of endothelial COX-2 in angiolysis. ..
  10. The Role of Tie2 and the Angiopoietins in EPC Biology
    GREGORY LAM; Fiscal Year: 2006
    ..We hypothesize that Tie2 is required for EPC-mediated vascular repair in atherosclerosis and that Ang2, but not Ang1, will enhance EPC repair of atherosclerotic lesions. The Specific Aims of this proposal are to: 1...
  11. Arup Das; Fiscal Year: 2015
    ..Successful completion of this project will have the high translational impact for a clinical trial for DME, and potentially lead to a "combination therapy" along with the current laser and anti-VEGF therapies. ..
  12. WEIBEL PALADE BODY FORMATION AND ROLE IN HEMOSTASIS
    DENISA WAGNER; Fiscal Year: 2007
    ..We will investigate how inhibition of a particular component[unreadable] of these vesicles could improve outcome in these major diseases. [unreadable]..
  13. Perenlei Enkhbaatar; Fiscal Year: 2016
    ..We are particularly optimistic about the possibility that the proposed research will lead to translational clinical studies for agonists of the selective V1aR and peroxynitrite modulators. ..
  14. Dianne M Finkelstein; Fiscal Year: 2016
    ..abstract_text> ..
  15. Chemoprevention of Bladder CA by soybean bioactive comp.
    Jin Rong Zhou; Fiscal Year: 2006
    ..abstract_text> ..
  16. Mechanisms of VEGF-A regulated tumor lymphangiogenesis
    Sophia Ran; Fiscal Year: 2007
    ..Because metastasis is a primary cause of mortality from cancer, these studies have the potential to significantly improve health outcomes in a large number of cancer patients. [unreadable] [unreadable] [unreadable]..
  17. Jian xiong Chen; Fiscal Year: 2014
    ..Our proposed studies should provide a framework for developing new therapeutic strategies for the treatment of diabetic impaired collateralization and angiogenesis. ..
  18. Role of Angiogenesis Following Stroke
    Patrick Lyden; Fiscal Year: 2006
    ..abstract_text> ..
  19. Kazuaki Takabe; Fiscal Year: 2016
    ..via the S1PR1 receptor on lymphatic endothelial cells (LECs) and it stimulates these cells to release angiopoietin 2 (Ang2), a critical regulator of lymphangiogenesis, whose levels in breast cancer correlate with metastases to ..
  20. Shou Jiang Gao; Fiscal Year: 2016
    ..This project will investigate the mechanism underlining the development of Kaposi's sarcoma, and identify potential targets for the prevention and treatment of this disease. ..
  21. Georgios I Papachristou; Fiscal Year: 2014
    ..e. tumor necrosis factor-a inhibitors. ..
  22. Weibel - Palade Bodies - Sentinels of Acute Ischemia
    Michael S Goligorsky; Fiscal Year: 2013
    ....
  23. Regulation of Angiopoietin mRNA Stability
    John Vogel; Fiscal Year: 2007
    ..through a challenging research proposal focused on signal transduction pathways associated with Angiopoietin-2 (Ang2) mRNA stability...
  24. Nitric Oxide and Malaria
    JOE BRICE WEINBERG; Fiscal Year: 2012
    ..Measured outcomes will be patient safety, arginine and nitrite pharmacokinetics, NO production, parasitemia, angiopoietin 2 levels, and endothelial function...
  25. Lu Chen; Fiscal Year: 2016
    ....
  26. INTRACELLULAR GLYCATION AND DIABETIC COMPLICATIONS
    Michael Brownlee; Fiscal Year: 2006
    ..Specific Aim 3 will characterize the mechanism of Angiopoietin 2 transcriptional control by glyoxalase I substrates in cultured primary retinal Muller cells...
  27. INTRACELLULAR GLYCATION AND DIABETIC COMPLICATIONS
    Michael Brownlee; Fiscal Year: 2007
    ..Supershift experiments will use commercially availableantibodies. IP-westernsof cell extracts will be immunoblotted with antibodies to glyoxalase I-substrate-derived advanced glycationendproducts. ..
  28. Angiogenesis in hyperoxic lung fibrosis
    Ivor Douglas; Fiscal Year: 2007
    ..Columbia University has an established record of successful mentorship and training for K08 Career awardees in their preparation for careers as independent. ..
  29. Prevention of bladder cancer progression by sulforaphane
    Jin Rong Zhou; Fiscal Year: 2005
    ..It is expected that the results will provide important information on anti-bladder cancer progression activity of sulforaphane, and provide preliminary data for R01 grant application. ..
  30. Triple Anti-Angiogenic Therapy for Brain Tumors
    W K Yung; Fiscal Year: 2007
    ..abstract_text> ..
  31. Angiopoietin-2 and Glioma Invasion
    Shi Yuan Cheng; Fiscal Year: 2008
    ..Recently, we have demonstrated that angiopoietin-2 (Ang2), a known angiogenic factor, induces glioma invasion through the activation of MMP-2 and membrane type-1 (MT1)-MMP...
  32. Effects of the Angiopoietins on Tie 2 Downregulation
    Christopher Kontos; Fiscal Year: 2005
    ..In contrast, Ang2 appears to inhibit Angl's vascular stabilizing effects, and in some cases Ang2 is required for angiogenesis...
  33. TIE2-Associated Molecular Targets in Tumor Vasculature
    DANIEL KENAN; Fiscal Year: 2003
    ..The ligands for Tie2-Angiopoietin-1 (Ang1) and Ang2-each exhibit opposite effects on the vasculature...
  34. Regulation of Angiogenesis During Wound Healing
    Eric Howard; Fiscal Year: 2005
    ..b>Ang2, an antagonist of the Tie2 receptor, blocks these signals by competing for Ang1 binding, and is necessary for the ..
  35. FETAL HYPOXEMIA AND ENDOTHELIUM DERIVED NITRIC OXIDE
    Loren P Thompson; Fiscal Year: 2010
    ..Apoptosis (Bax/Bcl2 expression, TUNEL) and coronary angiogenesis (VEGF, VEGFR1, VEGFR2, Ang1, Ang2 expression) will be quantified and functional responses of coronary flow and contractile force measured in isolated ..
  36. Novel Small-Molecule Inhibitors of the Tie2/Angiopoietin Interactions and Signali
    Dimitar Nikolov; Fiscal Year: 2007
    ..to screen a complete compound library for small molecules that disrupt respectively the Tie2/Ang1 and the Tie2/Ang2 complex formation...
  37. Rakesh K Jain; Fiscal Year: 2016
    ..The new Projects 1, 2 and 3 leverage our observation that both common (SDF1a/CXCR4) and specific (ANG2, IL-6, MEK) pathways are activated during anti-VEGF treatments of human glioblastoma, colorectal and hepatocellular ..
  38. Edward Cantu; Fiscal Year: 2016
    ..The proposal maps a clear plan to allow the candidate to become an independent clinical investigator in patient-oriented translational research. ..
  39. EXERCISE TRAINING AND PERIPHERAL ARTERIAL INSUFFICIENCY
    RONALD TERJUNG; Fiscal Year: 2004
    ..signaling of NO, alters regulation of VEGF and its receptors (VEGFR-1 and VEGFR-2), and the angiopoietins (Ang1 and Ang2, and their receptor Tie2) is modified to stimulate arteriogenesis in collateral vessels in vivo, using real-time ..
  40. NUALA JENNINGS MEYER; Fiscal Year: 2014
    ....
  41. Lei Wang; Fiscal Year: 2016
    ..3. The PI3K/Akt signaling pathway underlies the effect of Tbeta4 on Ang1/Ang2 expression...
  42. CULTURED EPIDERMAL GRAFTS FOR BURN PATIENTS
    Meena Katdare; Fiscal Year: 2005
    ..g., VEGF, FGF, Ang1 and Ang2) on the time course of wound repair, and B...
  43. Understanding vessel regression
    Andrius Kazlauskas; Fiscal Year: 2007
    ..In the first one, PLCg induces expression of cellular factors such as angiopoetin 2 (Ang2) that induce vessel destabilization/regression...
  44. ENDOTHELIAL CELL GROWTH AND MATURATION IN A 3D CULTURE
    Carlyne Cool; Fiscal Year: 2003
    ..Since Angiopoietin (Ang)1, Ang2, and VEGF cause progressive maturation and organization of ECs lining blood vessel lumina, we also hypothesize that ..
  45. Angiogenic Agents and Alveolar Injury
    Vineet Bhandari; Fiscal Year: 2007
    ..We undertook studies designed to determine if VEGF, Angiopoietin 1 or Angiopoietin 2 are regulated by hyperoxia-induced acute lung injury...
  46. Pericytes in Pathogenesis of Germinal-Matrix Hemorrhage
    Praveen Ballabh; Fiscal Year: 2006
    ..Our data may help in understanding the etiology of GMH and may explain the basis of prenatal glucocorticoid therapy. It may also identify new strategies in the prevention and treatment of GMH. [unreadable] [unreadable]..
  47. CELL SUBPOPULATIONS IN THE PRIMATE CORPUS LUTEUM
    Richard Stouffer; Fiscal Year: 2001
    ..Overall, the proposed research may have relevance to an understanding of certain ovarian disorders such as ovarian hyperstimulation syndrome and luteal phase defects where microvasculature growth may be disrupted. ..
  48. Role of TGF-Alpha in Pulmonary Vascular Disease
    TIMOTHY LE CRAS; Fiscal Year: 2006
    ..This information will serve as a basis for developing therapeutic strategies aimed at improving lung growth and preventing pulmonary hypertension in premature babies and adults. ..
  49. Cytoprotection by VEGF and HO-1 in Hyperoxic Lung Injury
    JONATHAN SINER; Fiscal Year: 2005
    ..These investigations will provide insight into the cytoprotective effects of HO-1 and VEGF and mechanisms of protection from hyperoxic acute lung injury. ..
  50. Osteoprotegerin and osteopontin in aortic aneurysm
    Jonathan Golledge; Fiscal Year: 2009
    ..Understanding the role of these calcium-controlling proteins in artery weakness and how drug therapy can interfere in these effects is an important step in the development of new treatment for aortic aneurysm. ..
  51. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 2002
    ..abstract_text> ..
  52. Fox genes in urinary tract development
    Tsutomu Kume; Fiscal Year: 2005
    ..abstract_text> ..
  53. Extracellular matrix and protease markers of malignant thyroid neoplasm
    Electron Kebebew; Fiscal Year: 2007
    ..We will use these results to design a multicenter clinical trial evaluating the diagnostic and prognostic value of ECM1 and TMPRSS4 expression in patients with thyroid neoplasm. [unreadable] [unreadable] [unreadable]..
  54. Multidisciplinary Program in Female and Male Reproduction
    EUGENE ALBRECHT; Fiscal Year: 2008
    ..The discoveries obtained in the baboon primate model are expected to translate to the human to advance knowledge of human reproductive biology. [unreadable] [unreadable]..
  55. REGIONAL BRAIN PHI AND RECOVERY FROM CARDIAC ARREST
    Joseph LaManna; Fiscal Year: 2001
    ..Some animals will also be treated with Na+/H+ transport inhibitors to provide further support that this transporter promotes postischemic intracellular alkalosis and worsens neurological outcome. ..
  56. Is There a Link Between Alzheimer's and Atheroclerosis
    Paula Grammas; Fiscal Year: 2007
    ..abstract_text> ..
  57. Comparative DNA Microarray Analysis of Brain Tumors
    Daniel Brat; Fiscal Year: 2006
    ....
  58. MOLECULAR GENETICS OF HEREDITARY PANCREATITIS
    David Whitcomb; Fiscal Year: 2008
    ..The HP and familial pancreatitis studies are especially important because of the statistical power of family studies and the ability to detect modifier genes in a uniform background of susceptibility factors. ..
  59. 14th Internatinal Symposium on Inherited Diseases
    David Whitcomb; Fiscal Year: 2004
    ..The format, venue, and content are designed to maximize participation, education, translation and implementation of the key elements of the many new findings in the genetics of the pancreas. ..
  60. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  61. Therapeutic Modulation of COX-2-induced Immunosuppression in Metastatic RCC
    Brian Rini; Fiscal Year: 2008
    ..This project will have broad implications for the immunoregulation of cancer and how expression and modulation of COX-2 expression influences the immune response to cancer. [unreadable] [unreadable] [unreadable]..
  62. NAPS2 Continuation - Genome-Wide Association Study of Pancreatitis
    David C Whitcomb; Fiscal Year: 2010
    ..Knowledge of the genetic basis of pancreatitis will lead to new treatments, and help remove the stigma that chronic pancreatitis is only a disease of drunkards. ..
  63. Conceptus-Dependent Effects on the Endometrium
    Brent Bany; Fiscal Year: 2009
    ....
  64. Hypoxia-Inducible Factor 1 and Oxygen Homeostasis
    Gregg Semenza; Fiscal Year: 2009
    ....
  65. Mechanisms of myometrial healing and regeneration
    Catalin Buhimschi; Fiscal Year: 2006
    ....
  66. Vascular inflammation and neurotoxicity in aging brain
    Paula Grammas; Fiscal Year: 2009
    ....
  67. Treatment strategies in a rat model of cardiac arrest
    Joseph LaManna; Fiscal Year: 2005
    ..Another set of experimental protocols will elucidate specific mechanism(s) by which the selected energy substrates and agents and are effective. ..
  68. Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.
    Daniel J Brat; Fiscal Year: 2010
    ..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. ..
  69. Intravascular Thrombosis in Glioblastoma
    Daniel Brat; Fiscal Year: 2005
    ..Our emerging model represents a paradigm shift in the understanding of GBM and should lead directly to more effective therapies. ..