AMOT

Summary

Gene Symbol: AMOT
Description: angiomotin
Alias: angiomotin, angiomotin p130 isoform, angiomotin p80 isoform
Species: human

Top Publications

  1. ncbi Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation
    Huizhe Huang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Development 134:979-88. 2007
  2. ncbi A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells
    Clark D Wells
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Cell 125:535-48. 2006
  3. pmc Amot recognizes a juxtanuclear endocytic recycling compartment via a novel lipid binding domain
    Brigitte Heller
    Department of Biochemistry and Molecular Biology, University of Indiana School ofMedicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 285:12308-20. 2010
  4. pmc Angiomotin-like proteins associate with and negatively regulate YAP1
    Wenqi Wang
    Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 286:4364-70. 2011
  5. doi Human angiomotin-like 1 associates with an angiomotin protein complex through its coiled-coil domain and induces the remodeling of the actin cytoskeleton
    Valérie Gagné
    Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHUQ CHUL, Department of Anatomy and Physiology, Universite Laval, Boul Laurier, Quebec, Quebec, Canada
    Cell Motil Cytoskeleton 66:754-68. 2009
  6. pmc Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein
    Bin Zhao
    Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 25:51-63. 2011
  7. pmc Hippo pathway-independent restriction of TAZ and YAP by angiomotin
    Siew Wee Chan
    Cancer and Developmental Cell Biology Division, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673
    J Biol Chem 286:7018-26. 2011
  8. ncbi p130-angiomotin associates to actin and controls endothelial cell shape
    Mira Ernkvist
    Department of Oncology Pathology, Cancer Centre Karolinska Institute, Stockholm, Sweden
    FEBS J 273:2000-11. 2006
  9. ncbi Angiomotin regulates endothelial cell-cell junctions and cell motility
    Anders Bratt
    Department of Oncology and Pathology, Cancer Centrum Karolinska, Karolinska Institutet, R8 03 Karolinska University Hospital, 171 76 Stockholm, Sweden
    J Biol Chem 280:34859-69. 2005
  10. pmc Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation
    Siew Wee Chan
    From the Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673 and
    J Biol Chem 288:37296-307. 2013

Research Grants

  1. ANN CAROL KIMBLE-HILL; Fiscal Year: 2016
  2. CLARK DAVID WELLS; Fiscal Year: 2015

Scientific Experts

  • Miguel A Sogorb
  • Khalid Amine Timani
  • Wenqi Wang
  • Hiroshi Sasaki
  • Wendong Ruan
  • Wanjin Hong
  • P Celec
  • B R Zetter
  • Hiromichi Matsumoto
  • Anders Bratt
  • Lars Holmgren
  • Mira Ernkvist
  • Clark D Wells
  • Yujuan Zheng
  • Tetyana Levchenko
  • Chunling Yi
  • Meng Lv
  • ANN CAROL KIMBLE-HILL
  • Karin Aase
  • CLARK DAVID WELLS
  • Jin Yang
  • Jacob J Adler
  • Siew Wee Chan
  • William P Ranahan
  • Akihiko Shimono
  • Peijun Liu
  • Maddalena Arigoni
  • Niina Veitonmaki
  • Murugan Paramasivam
  • Bin Zhao
  • Federica Cavallo
  • Brigitte Heller
  • Huizhe Huang
  • Arindam Majumdar
  • Maria J G Fernandes
  • Hung Thanh Nguyen
  • Aleksandar I Mihajlovic
  • Y Wang
  • Yan Zhang
  • X Niu
  • Craig I Campbell
  • Olivier Birot
  • Anna C Denicol
  • Haige Zhang
  • Andrew Archibald
  • Y L Hsu
  • Angelica Ortiz
  • Christopher M Cox
  • Gaëlle Mercenne
  • Julie Moreau
  • Giuseppina Barutello
  • A C Denicol
  • W Bossuyt
  • Jang Yul Byun
  • Sebastian Mana-Capelli
  • Wei Li
  • M Sudol
  • Jimmy Stalin
  • Xiaoming Dai
  • Brigitte L Heller
  • Lauren R Bringman
  • Dannel McCollum
  • Di Wu
  • Anat Stemmer-Rachamimov
  • Chenji Wang
  • Joseph L Kissil
  • Zhiqiang Li
  • Chun Jye Lim
  • T Oka
  • Kun Liang Guan
  • Scott Troutman
  • Chuanshen Wu
  • Claire Webb
  • Whitney Smith-Kinnaman
  • Yong Yu
  • Nathalie Luna Persson
  • Arie Horowitz
  • Yeqi Wang
  • Anming Meng
  • Stéphane Audebert
  • Claudia Curcio
  • Valérie Gagné
  • Jean Paul Borg
  • Manuela Iezzi
  • Indranil Sinha
  • Staffan Nyström
  • Yue Ming
  • Anders Kvanta
  • Billie A Moore-Scott
  • Yuko Sugihara-Mizuno

Detail Information

Publications73

  1. ncbi Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation
    Huizhe Huang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Development 134:979-88. 2007
    b>Angiomotin (Amot), the founding member of the Motin family, is involved in angiogenesis by regulating endothelial cell motility, and is required for visceral endoderm movement in mice...
  2. ncbi A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells
    Clark D Wells
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Cell 125:535-48. 2006
    ..Rich1 binds the scaffolding protein angiomotin (Amot) and is thereby targeted to a protein complex at tight junctions (TJs) containing the PDZ-domain proteins ..
  3. pmc Amot recognizes a juxtanuclear endocytic recycling compartment via a novel lipid binding domain
    Brigitte Heller
    Department of Biochemistry and Molecular Biology, University of Indiana School ofMedicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 285:12308-20. 2010
    ..arrangement for the Par and Crb apical polarity complexes at the tight junction is disrupted by the adaptor protein Amot. Amot directly binds the scaffolding proteins Patj and Mupp1 and redistributes them and their binding partners from ..
  4. pmc Angiomotin-like proteins associate with and negatively regulate YAP1
    Wenqi Wang
    Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 286:4364-70. 2011
    ..Here, we describe the identification of several new PY motif-containing proteins, including angiomotin-like protein 1 (AMOTL1) and 2 (AMOTL2), as YAP1-associated proteins...
  5. doi Human angiomotin-like 1 associates with an angiomotin protein complex through its coiled-coil domain and induces the remodeling of the actin cytoskeleton
    Valérie Gagné
    Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHUQ CHUL, Department of Anatomy and Physiology, Universite Laval, Boul Laurier, Quebec, Quebec, Canada
    Cell Motil Cytoskeleton 66:754-68. 2009
    ..One mechanism through which angiostatin inhibits angiogenesis is by binding to the cell surface protein p80-angiomotin. The p80-angiomotin protein promotes angiogenesis, in part, by conferring a hypermigratory phenotype to ..
  6. pmc Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein
    Bin Zhao
    Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 25:51-63. 2011
    ..Here we report a novel mechanism of YAP regulation by angiomotin (AMOT) family proteins via a direct interaction...
  7. pmc Hippo pathway-independent restriction of TAZ and YAP by angiomotin
    Siew Wee Chan
    Cancer and Developmental Cell Biology Division, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673
    J Biol Chem 286:7018-26. 2011
    ..describe an independent mechanism for the cell to restrict the activity of TAZ and YAP through interaction with angiomotin (Amot) and angiomotin-like 1 (AmotL1)...
  8. ncbi p130-angiomotin associates to actin and controls endothelial cell shape
    Mira Ernkvist
    Department of Oncology Pathology, Cancer Centre Karolinska Institute, Stockholm, Sweden
    FEBS J 273:2000-11. 2006
    b>Angiomotin, an 80 kDa protein expressed in endothelial cells, promotes cell migration and invasion, and stabilizes tube formation in vitro...
  9. ncbi Angiomotin regulates endothelial cell-cell junctions and cell motility
    Anders Bratt
    Department of Oncology and Pathology, Cancer Centrum Karolinska, Karolinska Institutet, R8 03 Karolinska University Hospital, 171 76 Stockholm, Sweden
    J Biol Chem 280:34859-69. 2005
    We have previously identified angiomotin by its ability to bind to and mediate the anti-angiogenic properties of angiostatin. In vivo and in vitro data indicate an essential role of angiomotin in endothelial cell motility...
  10. pmc Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation
    Siew Wee Chan
    From the Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673 and
    J Biol Chem 288:37296-307. 2013
    ..In this report, we have identified angiomotin (Amot) family members as novel substrates of Hippo core kinases...
  11. pmc Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis
    Xiaoming Dai
    From the Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou, Zhejiang 310058, China
    J Biol Chem 288:34041-51. 2013
    ..Here we report a novel role of the Hippo pathway in angiogenesis. Angiomotin p130 isoform (AMOTp130) is phosphorylated on a conserved HXRXXS motif by Lats1/2 downstream of GPCR signaling...
  12. pmc Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases
    Jacob J Adler
    Department of Biochemistry and Molecular Biology, Department of Ophthalmology, Glick Eye Institute, and Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202
    Proc Natl Acad Sci U S A 110:17368-73. 2013
    ..Here low serum and high LATS1 activity are found to enhance the levels of the 130-kDa isoform of angiomotin (Amot130) through phosphorylation by LATS1/2 at serine 175, which then forms a binding site for 14-3-3...
  13. pmc Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation
    B Troyanovsky
    Center for Genomics Research and Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 76 Stockholm, Sweden
    J Cell Biol 152:1247-54. 2001
    ..Here we report the identification of angiomotin, a novel protein that mediates angiostatin inhibition of migration and tube formation of endothelial cells...
  14. pmc Amot130 adapts atrophin-1 interacting protein 4 to inhibit yes-associated protein signaling and cell growth
    Jacob J Adler
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 288:15181-93. 2013
    ..Thus, Amot130 repurposes AIP4 from its previously described role in degrading large tumor suppressor 1 to the inhibition of YAP and cell growth...
  15. pmc Angiomotins link F-actin architecture to Hippo pathway signaling
    Sebastian Mana-Capelli
    Department of Biochemistry and Molecular Pharmacology and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, MA 01605
    Mol Biol Cell 25:1676-85. 2014
    ..Here we show that angiomotin proteins (AMOT130, AMOTL1, and AMOTL2) connect F-actin architecture to YAP regulation...
  16. doi Overexpression of angiomotin in sinonasal inverted papilloma
    Jang Yul Byun
    Department of Otorhinolaryngology Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon, Korea
    Int Forum Allergy Rhinol 4:512-6. 2014
    ..Generally, tumorigenesis or tumor growth requires angiogenesis to feed tumor cells. Angiomotin is a recently discovered protein that regulates migration and tubule formation in endothelial cells...
  17. doi Position- and polarity-dependent Hippo signaling regulates cell fates in preimplantation mouse embryos
    Hiroshi Sasaki
    Laboratory for Embryogenesis, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan Electronic address
    Semin Cell Dev Biol 47:80-7. 2015
    ..At the molecular level, phosphorylation of the Hippo-pathway component angiomotin at adherens junctions (AJs) in the inner (apolar) cells activates the Lats protein kinase and triggers Hippo ..
  18. doi Regulation of ubiquitin-proteasome system-mediated Tip110 protein degradation by USP15
    Khalid Amine Timani
    Department of Cell Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA Electronic address
    Int J Biochem Cell Biol 54:10-9. 2014
    ..Interestingly, USP15 knockdown restored hTip110 protein expression in Tg MEF and USP15 expression had little effects. Taken together, these results provide insights into the regulatory mechanism of human Tip110 degradation by USP15. ..
  19. pmc Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus
    Wei Li
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA Electronic address
    Cancer Cell 26:48-60. 2014
    ..Analysis of clinical samples confirms that this pathway operates in NF2-mutant tumors. We conclude that derepressed CRL4(DCAF1) promotes activation of YAP by inhibiting Lats1 and 2 in the nucleus. ..
  20. doi Angiomotin decreases lung cancer progression by sequestering oncogenic YAP/TAZ and decreasing Cyr61 expression
    Y L Hsu
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Oncogene 34:4056-68. 2015
    ..Lung cancer is the leading cause of cancer death worldwide, with metastasis underlying majority of related deaths. Angiomotin (AMOT), a scaffold protein, has been shown to interact with oncogenic Yes-associated protein/transcriptional co-..
  21. pmc Angiomotin is a novel component of cadherin-11/β-catenin/p120 complex and is critical for cadherin-11-mediated cell migration
    Angelica Ortiz
    Departments of Translational Molecular Pathology and Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA University of Texas Graduate School of Biomedical Sciences, Houston, Texas, USA and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    FASEB J 29:1080-91. 2015
    ..Using the human Cad11 cytoplasmic domain in pulldown assays, we identified human angiomotin (Amot), known to be involved in cell polarity, migration, and Hippo pathway, as a component of the Cad11 protein ..
  22. doi 3 sex influences regulation of gene expression by dickkopf 1 in the bovine morula
    A C Denicol
    University of Florida, Gainesville, FL, USA
    Reprod Fertil Dev 27:94. 2014
    ..DKK1 inhibited expression of AMOT in male embryos, indicating that DKK1 may inhibit Hippo signalling at this stage of development...
  23. pmc Angiomotin functions in HIV-1 assembly and budding
    Gaëlle Mercenne
    Department of Biochemistry, University of Utah, Salt Lake City, United States
    elife 4:. 2015
    ..Here, we demonstrate that the cellular protein Angiomotin (AMOT) can bind both NEDD4L and HIV-1 Gag...
  24. pmc An evolutionary shift in the regulation of the Hippo pathway between mice and flies
    W Bossuyt
    1 Vlaams Instituut voor Biotechnologie VIB Center for the Biology of Disease, Leuven, Belgium 2 Kuleuven, Center for Human Genetics, Leuven, Belgium 3 The University of Texas, MD Anderson Cancer Center, Houston, TX, USA
    Oncogene 33:1218-28. 2014
    ..Subsequently, the junctional adaptor protein Angiomotin (Amot) was lost and the downstream effector Yap lost its PDZ-binding motif that interacts with cell junction ..
  25. pmc Angiomotin promotes renal epithelial and carcinoma cell proliferation by retaining the nuclear YAP
    Meng Lv
    Department of Medical Oncology, The First Affiliated Hospital of Xian Jiaotong University, Xi an, Shaanxi 710061, P R China
    Oncotarget 7:12393-403. 2016
    Renal cell carcinoma (RCC) is one of the common tumors in the urinary system without effective therapies. Angiomotin (Amot) can interact with Yes-associated protein (YAP) to either stimulate or inhibit YAP activity, playing a potential ..
  26. pmc DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins
    Hung Thanh Nguyen
    Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 12:e0169587. 2017
    ..proteins regulate YAP/TAZ activity by controlling the stability of the E3 ligase ITCH, the LATS kinases and the AMOT family proteins...
  27. doi Angiomotin promotes the malignant potential of colon cancer cells by activating the YAP-ERK/PI3K-AKT signaling pathway
    Yan Zhang
    Department of Medical Imaging, The First Affiliated Hospital of Xi an Jiaotong University College of Medicine, Xi an, Shaanxi 710061, P R China
    Oncol Rep 36:3619-3626. 2016
    ..The aberrant expression of angiomotin (AMOT) has been confirmed in a variety of tumors and can interact with Yes-associated protein (YAP) to either ..
  28. doi The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin
    Craig I Campbell
    Center for Systems Biology, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    J Cell Sci 129:3396-411. 2016
    ..We show that RNF146 binds a number of polarity-associated proteins, in particular members of the angiomotin (AMOT) family...
  29. pmc Angiomotin like-1 is a novel component of the N-cadherin complex affecting endothelial/pericyte interaction in normal and tumor angiogenesis
    Yujuan Zheng
    Department of Oncology and Pathology, Cancer Centrum Karolinska, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Sci Rep 6:30622. 2016
    ..We have previously identified the Amot protein family, which are scaffold proteins that integrate polarity, junctional, and cytoskeletal cues to modulate ..
  30. doi Rho-associated protein kinase regulates subcellular localisation of Angiomotin and Hippo-signalling during preimplantation mouse embryo development
    Aleksandar I Mihajlovic
    Laboratory of Developmental Biology and Genetics LDB and G, Department of Molecular Biology, Faculty of Science, University of South Bohemia, Branisovska 31, Ceske Budejovice 37005, Czech Republic
    Reprod Biomed Online 33:381-90. 2016
    ..Moreover, Rock-inhibition mediates mislocalization of the Hippo-signalling activator Angiomotin (Amot), to the basolateral regions of outer cells and is concomitant with aberrant activation of the pathway...
  31. pmc PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis
    Y Wang
    Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    Oncogene . 2016
    ..Lentiviral shRNA-mediated knockdown (KD) of PKCι leads to decreased nuclear YAP1 and increased YAP1 binding to angiomotin (AMOT), which sequesters YAP1 in the cytoplasm...
  32. pmc MicroRNA-497 inhibits cell proliferation, migration, and invasion by targeting AMOT in human osteosarcoma cells
    Wen Dong Ruan
    Department of Orthopedics, Tianjin Medical University General Hospital, Heping District, Tianjin, People s Republic of China
    Onco Targets Ther 9:303-13. 2016
    ..b>Angiomotin is encoded by the AMOT gene, which is a target for miR-497...
  33. doi Angiomotin promotes breast cancer cell proliferation and invasion
    Meng Lv
    Department of Oncology, The First Affiliated Hospital, Xi an Jiaotong University College of Medicine, Xi an, Shaanxi 710061, P R China
    Oncol Rep 33:1938-46. 2015
    b>Angiomotin (Amot) is a multifunctional protein involved in endothelial cell migration and tube formation and angiogenesis...
  34. doi mRNA and protein expression of the angiogenesis-related genes EDIL3, AMOT and ECM1 in mesenchymal stem cells in psoriatic dermis
    X Niu
    Institute of Dermatology, Taiyuan City Central Hospital, Taiyuan, Shanxi, China
    Clin Exp Dermatol 41:533-40. 2016
    ..angiogenesis-related genes EDIL3 (epidermal growth factor-like repeats and discoidin I-like domains 3), AMOT (angiomotin) and ECM1 (extracellular matrix protein 1), had high expression levels in dermal mesenchymal stem cells (DMSCs) ..
  35. doi Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes cell proliferation and migration by upregulating angiomotin gene expression in human osteosarcoma cells
    Wendong Ruan
    Department of Orthopedic, Tianjin Medical University General Hospital, No 154 Anshan Road, Heping District, Tianjin, People s Republic China
    Tumour Biol 37:4065-73. 2016
    ..b>Angiomotin, encoded by the AMOT gene, is a protein that regulates the migration and organization of endothelial cells...
  36. pmc Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins
    Wenqi Wang
    Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA Electronic address
    Cell Rep 13:524-32. 2015
    ..Here, we find that tankyrase inhibitors suppress YAP activity. This effect is mediated by anigomotin (AMOT) family proteins...
  37. pmc Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling
    Andrew Archibald
    Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada Division of Experimental Medicine, McGill University, Montreal, QC H3A 1A3, Canada
    Mol Biol Cell 26:3578-95. 2015
    ..In MDCK cells, Yap1 was sequestered to cell-cell junctions by Amot, and aPKC overexpression resulted in loss of Amot expression and a spindle-like cell phenotype...
  38. doi MicroRNA-205 inhibits the proliferation and invasion of breast cancer by regulating AMOT expression
    Haige Zhang
    Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P R China
    Oncol Rep 34:2163-70. 2015
    It has been reported that the expression of angiomotin (AMOT) is upregulated in breast cancer. However, the regulatory mechanism remains unknown...
  39. pmc Influence of Sex on Basal and Dickkopf-1 Regulated Gene Expression in the Bovine Morula
    Anna C Denicol
    Department of Animal Sciences, D H Barron Reproductive and Perinatal Biology Research Program, and Genetics Institute, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 10:e0133587. 2015
    ..The exception was for the Hippo signaling gene AMOT, which was inhibited by DKK1...
  40. pmc Endosomal regulation of contact inhibition through the AMOT:YAP pathway
    Christopher M Cox
    Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85724
    Mol Biol Cell 26:2673-84. 2015
    ..In addition to phosphorylation-dependent regulation of YAP, the integral membrane protein angiomotin (AMOT) and AMOT family members control YAP through direct binding...
  41. pmc The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis
    Chunling Yi
    Molecular Oncology Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Sci Signal 6:ra77. 2013
    ..Members of the scaffold protein angiomotin (Amot) family interact with several Hippo pathway components, including Yap (Yes-associated protein), and either ..
  42. doi Angiomotin'g YAP into the nucleus for cell proliferation and cancer development
    Wanjin Hong
    Institute of Molecular and Cell Biology, Singapore
    Sci Signal 6:pe27. 2013
    ..Scaffold proteins angiomotin (Amot) and angiomotin-related AmotL1 and AmotL2 were recently identified as negative regulators of YAP and TAZ ..
  43. pmc Membrane traffic as a coordinator of cell migration and junction remodeling
    Chuanshen Wu
    Department of Molecular Cardiology, Cleveland Clinic Lerner College of Medicine Cleveland, OH USA
    Commun Integr Biol 4:703-5. 2011
    ..RhoA-specific guanine exchange factor (GEF) Syx, the scaffold protein Mupp1, and the phospholipid binding protein Amot.1 We found that RhoA co-trafficked with this complex on the same endocytic vesicles, and that its cellular activity ..
  44. pmc Soluble melanoma cell adhesion molecule (sMCAM/sCD146) promotes angiogenic effects on endothelial progenitor cells through angiomotin
    Jimmy Stalin
    Inserm UMR S 1076, Physiopathology of Endothelium, Aix Marseille University, Formation and Research Unit of Pharmacy, 13005 Marseille, France
    J Biol Chem 288:8991-9000. 2013
    ..Using peptide pulldown and mass spectrometry, we identified angiomotin as a sCD146-associated protein in endothelial progenitor cells (EPC)...
  45. pmc PTPN14 is required for the density-dependent control of YAP1
    Wenqi Wang
    Department of Experimental Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 26:1959-71. 2012
    ..Collectively, these data suggest that PTPN14 acts to suppress cell proliferation by promoting cell density-dependent cytoplasmic translocation of YAP1...
  46. ncbi Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation
    Hiromichi Matsumoto
    Laboratory of Animal Breeding and Reproduction, Division of Animal Science, Faculty of Agriculture, Utsunomiya University, Tochigi 321 8505, Japan
    J Reprod Dev 58:649-53. 2012
    Increased vascular permeability and angiogenesis are hallmarks of the implantation process in the uterus. Angiomotin (Amot), which is a vascular angiogenesis-related protein, belongs to the motin family...
  47. doi Proteomic identification of angiomotin by ProteomeLab PF-2D and correlation with clinical outcome in human clear cell renal cell carcinoma
    Jin Yang
    Medical Oncology Department, The First Affiliated Hospital, College of Medicine, Xi an Jiaotong University, Xi an 710061, P R China
    Int J Oncol 42:2078-86. 2013
    ..Of the 13 differentially expressed proteins newly discovered in ccRCC, angiomotin (Amot) was the focus of this study since its role in ccRCC progression has been obscure...
  48. pmc A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors
    Maddalena Arigoni
    Molecular Biotechnology Center, University of Turin, Turin, Italy
    Angiogenesis 15:305-16. 2012
    b>Angiomotin (Amot) is one of several identified angiostatin receptors expressed by the endothelia of angiogenic tissues...
  49. doi The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation
    Chenji Wang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, PR China
    Biochem J 444:279-89. 2012
    AMOT (angiomotin) is a membrane-associated protein that is expressed in ECs (endothelial cells) and controls migration, TJ (tight junction) formation, cell polarity and angiogenesis...
  50. pmc The Amotl2 gene inhibits Wnt/β-catenin signaling and regulates embryonic development in zebrafish
    Zhiqiang Li
    State Key Laboratory of Biomembrane and Membrane Engineering, Tsinghua Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
    J Biol Chem 287:13005-15. 2012
    ..is up-regulated due to an axin1 mutation, transforms eyeless phenotype into smaller eyes, whereas co-knockdown of amot, amotl1, and amotl2 leads to development of smaller eyes in mbl heterozygotes...
  51. pmc The effects of anti-inflammatory and anti-angiogenic DNA vaccination on diabetic nephropathy in rats
    Peter Celec
    Institute of Molecular Biomedicine, Comenius University, 811 08 Bratislava, Slovakia
    Hum Gene Ther 23:158-66. 2012
    ..b>Angiomotin (Amot) is a novel angiogenesis modulator...
  52. ncbi Identification of molecular markers that are expressed in discrete anterior-posterior domains of the endoderm from the gastrula stage to mid-gestation
    Billie A Moore-Scott
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Dev Dyn 236:1997-2003. 2007
    ..We have identified three genes Slc39a8, Amot, and Dp1l1, which are expressed in the visceral endoderm at e7.5. Starting at e9...
  53. ncbi Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties
    Yuko Sugihara-Mizuno
    Department of Cell Biology, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 12:473-86. 2007
    ..Using yeast two-hybrid screening, we found here that MUPP1 interacts with angiomotin (Amot), JEAP/Amot-like 1 and MASCOT/Amot-like 2, which we refer to as Amot/JEAP family proteins...
  54. pmc A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth
    Lars Holmgren
    Department of Oncology and Pathology, Cancer Centre Karolinska, Karolinska Institutet, SE171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 103:9208-13. 2006
    ..Here, we describe a strategy that targets the angiostatin receptor angiomotin (Amot) by DNA vaccination...
  55. ncbi Protein diversity is generated within the motin family of proteins by alternative pre-mRNA splicing
    Julie Moreau
    Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHUL, Laval University, Bloc T1 492705, Boul Laurier, Ste Foy, Quebec, Canada G1V 4G2
    Gene 350:137-48. 2005
    The motin family of proteins is comprised of three polypeptides, angiomotin, angiomotin-like 1, and angiomotin-like 2. Angiomotin is an angiostatin-binding protein that promotes endothelial cell motility and is involved in angiogenesis...
  56. ncbi Angiomotin expression promotes hemangioendothelioma invasion
    Tetyana Levchenko
    Department of Oncology Pathology, Cancer Centre Karolinska Institute, S 17176, Stockholm, Sweden
    Oncogene 23:1469-73. 2004
    b>Angiomotin was identified by its ability to bind angiostatin and has been shown to mediate its activity in vitro...
  57. ncbi Loss of responsiveness to chemotactic factors by deletion of the C-terminal protein interaction site of angiomotin
    Tetyana Levchenko
    Department of Oncology Pathology, Cancer Center Karolinska Institutet, S 17176 Stockholm, Sweden
    J Cell Sci 116:3803-10. 2003
    We have recently identified a novel protein, named angiomotin, by its ability to bind the angiogenesis inhibitor angiostatin in the yeast two-hybrid system...
  58. ncbi Angiomotin regulates visceral endoderm movements during mouse embryogenesis
    Akihiko Shimono
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Curr Biol 13:613-7. 2003
    ..Little is known about the molecules that regulate this proximal displacement. Here we describe a role for mouse angiomotin (amot) in VE movements...
  59. ncbi Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains
    Anders Bratt
    Department of Oncology and Pathology, Karolinska Institutet, CCK R8 03 Karolinska Hospital, S 171 76 Stockholm, Sweden
    Gene 298:69-77. 2002
    b>Angiomotin has previously been identified in a yeast two-hybrid screen by its ability to bind to angiostatin, an inhibitor of novel formation of blood vessels (angiogenesis)...
  60. pmc Hold that line. Angiomotin regulates endothelial cell motility
    B R Zetter
    Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 152:F35-6. 2001
  61. pmc Angiomotin regulates endothelial cell migration during embryonic angiogenesis
    Karin Aase
    Department of Oncology Pathology, Cancer Center Karolinska, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Genes Dev 21:2055-68. 2007
    ..We have previously identified angiomotin (Amot) as a receptor for the angiogenesis inhibitor angiostatin...
  62. ncbi Therapeutic antibodies targeting angiomotin inhibit angiogenesis in vivo
    Tetyana Levchenko
    Department of Oncology and Pathology, Cancer Centre Karolinska, Karolinska Institute, SE 17176, Stockholm, Sweden
    FASEB J 22:880-9. 2008
    We have previously shown that angiomotin (Amot) mediates angiostatin inhibition of endothelial migration and tube formation in vitro...
  63. doi Differential roles of p80- and p130-angiomotin in the switch between migration and stabilization of endothelial cells
    Mira Ernkvist
    Cancer Centrum Karolinska, Department of Oncology and Pathology, Karolinska Institutet, CCK R8 03, 171 76 Stockholm, Sweden
    Biochim Biophys Acta 1783:429-37. 2008
    We have previously shown that angiomotin (Amot) plays an important role in growth factor-induced migration of endothelial cells in vitro...
  64. pmc The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells
    Mira Ernkvist
    Department of Oncology and Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Blood 113:244-53. 2009
    ..We have previously shown that angiomotin (Amot), a membrane-associated scaffold protein, plays a critical role during vascular patterning and endothelial ..
  65. doi Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis
    Yujuan Zheng
    Department of Oncology and Pathology, Cancer Centrum Karolinska, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Circ Res 105:260-70. 2009
    We have previously shown that angiomotin (Amot) is essential for endothelial cell migration during mouse embryogenesis. However, approximately 5% of Amot knockout mice survived without any detectable vascular defects...
  66. ncbi [Analysis of expression profiles of some tumor growth-related genes after silencing of pleiotrophin in human small cell lung cancer H446 cells]
    Yong Yu
    Department of Respiratory Medicine, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China
    Zhonghua Zhong Liu Za Zhi 32:405-9. 2010
    To investigate the changes in expression profiles of angiomotin (Amot), schlafen5 (Slfn5), metalloproteinase-9 (MMP-9) and vascular endothelial cell growth factor (VEGF), which are genes associated with angiogenesis, tumor growth and ..
  67. pmc The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases
    William P Ranahan
    Department of Biochemistry and Molecular Biology, University of Indiana School of Medicine, Indianapolis, Indiana 46202 5122, USA
    Cancer Res 71:2203-11. 2011
    ..This study demonstrates that the adaptor protein Amot, in addition to its established role in regulating cellular asymmetry, also promotes extracellular signal-regulated ..
  68. doi Structural features and ligand binding properties of tandem WW domains from YAP and TAZ, nuclear effectors of the Hippo pathway
    Claire Webb
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK BA2 7AY
    Biochemistry 50:3300-9. 2011
    ..Our results indicate that both WW domains in YAP and TAZ are functional and capable of enhanced affinity binding to multi-PPxY partner proteins such as LATS1, ErbB4, and AMOT.
  69. pmc A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions
    Chunling Yi
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Cancer Cell 19:527-40. 2011
    ..We have identified a tight-junction-associated protein complex comprising Merlin, Angiomotin, Patj, and Pals1...
  70. doi Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP
    T Oka
    Laboratory of Signal Transduction and Proteomic Profiling, Weis Center for Research, Geisinger Clinic, Danville, PA, USA
    Oncogene 31:128-34. 2012
    YAP (Yes-associated protein) oncogene has been found to form a stable complex with members of the Angiomotin (Amot) family of proteins, which bind WW domains of YAP and sequester the protein in the cytoplasm and junctional complexes...
  71. pmc Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor
    Murugan Paramasivam
    Department of Microbial and Physiological Systems and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 22:3725-33. 2011
    ..How LATS2 is activated by MST2 in response to changes in cell density is unknown. Here we identify the angiomotin-family tight junction protein AMOTL2 as a novel activator of LATS2...
  72. ncbi A new granulation method for compressed tablets [proceedings]
    M H Rubinstein
    J Pharm Pharmacol 28:67P. 1976

Research Grants2

  1. ANN CAROL KIMBLE-HILL; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): An essential property of all Amot proteins is a novel lipid-binding domain (ACCH domain) that demonstrates lipid selectivity and the ability to deform membranes...
  2. CLARK DAVID WELLS; Fiscal Year: 2015
    ..loss of cellular differentiation is coordinated with the induction of aberrant proliferation by the adaptor protein Amot. Because the breakdown of the apical polarity is one of the earliest essential steps for cells to be sensitized to ..