AMN

Summary

Gene Symbol: AMN
Description: amnion associated transmembrane protein
Alias: PRO1028, amnionless, protein amnionless, amnionless homolog, visceral endoderm-specific type 1 transmembrane protein
Species: human

Top Publications

  1. ncbi The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain
    S Kalantry
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Sciences of Cornell University, New York, New York, USA
    Nat Genet 27:412-6. 2001
  2. ncbi Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia
    Stephan M Tanner
    Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Nat Genet 33:426-9. 2003
  3. ncbi The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless
    John C Fyfe
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, USA
    Blood 103:1573-9. 2004
  4. pmc AMN directs endocytosis of the intrinsic factor-vitamin B(12) receptor cubam by engaging ARH or Dab2
    Gitte Albinus Pedersen
    Department of Medical Biochemistry, University of Aarhus, Ole Worms Alle, Bldg 1170 1171, Aarhus C, Denmark
    Traffic 11:706-20. 2010
  5. pmc Luminal expression of cubilin is impaired in Imerslund-Grasbeck syndrome with compound AMN mutations in intron 3 and exon 7
    Fares Namour
    Faculte de Medecine, INSERM U954 Nutrition, Genetics, and Environmental Risk Exposure, Vandoeuvre les Nancy, France
    Haematologica 96:1715-9. 2011
  6. pmc Ancient founder mutation is responsible for Imerslund-Gräsbeck Syndrome among diverse ethnicities
    Cameron M Beech
    Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Orphanet J Rare Dis 6:74. 2011
  7. ncbi [X-linked adrenoleukodystrophy]
    P Aubourg
    Service d endocrinologie et de neurologie pédiatrique, Hopital Saint Vincent de Paul, INSERM U745, 82, avenue Denfert Rochereau, 75014 Paris, France
    Ann Endocrinol (Paris) 68:403-11. 2007
  8. ncbi Peroxisomal disorders: genotype, phenotype, major neuropathologic lesions, and pathogenesis
    J M Powers
    Department of Pathology Neuropathology and Postmortem Medicine, University of Rochester Medical Center, NY 14642, USA
    Brain Pathol 8:101-20. 1998
  9. ncbi Cumulative and residual effects of repeated sewage sludge applications: forage productivity and soil quality implications in South Florida, USA
    Gilbert C Sigua
    USDA ARS, Subtropical Agricultural Research Station, Brooksville, FL, USA
    Environ Sci Pollut Res Int 12:80-8. 2005
  10. ncbi Granisetron is equivalent to ondansetron for prophylaxis of chemotherapy-induced nausea and vomiting: results of a meta-analysis of randomized controlled trials
    A Del Giglio
    Oncology and Hematology Discipline, ABC Foundation School of Medicine, Sao Paulo, Brazil
    Cancer 89:2301-8. 2000

Detail Information

Publications156 found, 100 shown here

  1. ncbi The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain
    S Kalantry
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Sciences of Cornell University, New York, New York, USA
    Nat Genet 27:412-6. 2001
    ..streak into these functional regions, we have cloned and functionally identified the gene disrupted in the amnionless (amn) mouse, which has a recessive, embryonic lethal mutation that interferes specifically with the formation ..
  2. ncbi Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia
    Stephan M Tanner
    Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Nat Genet 33:426-9. 2003
    The amnionless gene, Amn, on mouse chromosome 12 encodes a type I transmembrane protein that is expressed in the extraembryonic visceral layer during gastrulation...
  3. ncbi The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless
    John C Fyfe
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, USA
    Blood 103:1573-9. 2004
    ..I-GS-causing mutations are found in either of 2 genes encoding the epithelial proteins: cubilin and amnionless (AMN)...
  4. pmc AMN directs endocytosis of the intrinsic factor-vitamin B(12) receptor cubam by engaging ARH or Dab2
    Gitte Albinus Pedersen
    Department of Medical Biochemistry, University of Aarhus, Ole Worms Alle, Bldg 1170 1171, Aarhus C, Denmark
    Traffic 11:706-20. 2010
    ..Cubam is composed of two proteins: cubilin and amnionless. Cubilin harbors ligand binding capabilities, while amnionless provides membrane anchorage and potential ..
  5. pmc Luminal expression of cubilin is impaired in Imerslund-Grasbeck syndrome with compound AMN mutations in intron 3 and exon 7
    Fares Namour
    Faculte de Medecine, INSERM U954 Nutrition, Genetics, and Environmental Risk Exposure, Vandoeuvre les Nancy, France
    Haematologica 96:1715-9. 2011
    ..b>Amnionless, the gene product of AMN, is a transmembrane protein that binds tightly to the N-terminal end of cubilin, the ..
  6. pmc Ancient founder mutation is responsible for Imerslund-Gräsbeck Syndrome among diverse ethnicities
    Cameron M Beech
    Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Orphanet J Rare Dis 6:74. 2011
    ..malabsorption of cobalamin (Cbl) due to bi-allelic mutations in either the cubilin gene (CUBN) or the human amnionless homolog (AMN)...
  7. ncbi [X-linked adrenoleukodystrophy]
    P Aubourg
    Service d endocrinologie et de neurologie pédiatrique, Hopital Saint Vincent de Paul, INSERM U745, 82, avenue Denfert Rochereau, 75014 Paris, France
    Ann Endocrinol (Paris) 68:403-11. 2007
    ..5-12 years, but also 35% of adult males; 2) a form that mainly involves the spinal cord (adrenomyeloneuropathy, AMN) in adult males between 20-50 years and 50% of heterozygous women after the age of 40 years...
  8. ncbi Peroxisomal disorders: genotype, phenotype, major neuropathologic lesions, and pathogenesis
    J M Powers
    Department of Pathology Neuropathology and Postmortem Medicine, University of Rochester Medical Center, NY 14642, USA
    Brain Pathol 8:101-20. 1998
    ..The gene defect in adreno-leukodystrophy (ALD) / adrenomyeloneuropathy (AMN) involves an integral peroxisomal membrane protein...
  9. ncbi Cumulative and residual effects of repeated sewage sludge applications: forage productivity and soil quality implications in South Florida, USA
    Gilbert C Sigua
    USDA ARS, Subtropical Agricultural Research Station, Brooksville, FL, USA
    Environ Sci Pollut Res Int 12:80-8. 2005
    ....
  10. ncbi Granisetron is equivalent to ondansetron for prophylaxis of chemotherapy-induced nausea and vomiting: results of a meta-analysis of randomized controlled trials
    A Del Giglio
    Oncology and Hematology Discipline, ABC Foundation School of Medicine, Sao Paulo, Brazil
    Cancer 89:2301-8. 2000
    ..Because most of these trials compared ondansetron with granisetron, the authors conducted a meta-analysis to determine if the current data available show any therapeutic difference between them...
  11. ncbi Adrenal steroids in adrenomyeloneuropathy. Dehydroepiandrosterone sulfate, androstenedione and 17alpha-hydroxyprogesterone
    Maria Wichers-Rother
    Universitaetsklinikum Bonn, Institut für Klinische Biochemie, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Neurol 252:1525-9. 2005
    Adrenoleukodystrophy (ALD) and its adult variant adrenomyeloneuropathy (AMN) are X-linked diseases associated with a deficiency in the peroxisomal degradation of saturated very long chain fatty acids (VLCFA) resulting in an accumulation ..
  12. pmc Effects of stimulation of muscarinic receptors on bladder afferent nerves in the in vitro bladder-pelvic afferent nerve preparation of the rat
    Yongbei Yu
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Brain Res 1361:43-53. 2010
    ..These effects were blocked by intravesical injection of 5 μM atropine methyl nitrate (AMN). Intravesical administration of 5 μM AMN alone did not alter BAN firing or the amplitude of bladder contractions...
  13. ncbi Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules
    Sharon Strope
    Molecular Biology Graduate Program, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    Development 131:4787-95. 2004
    Impaired primitive streak assembly in the mouse amnionless (amn) mutant results in the absence of non-axial trunk mesoderm, a derivative of the middle region of the primitive streak...
  14. ncbi Protective effects of S+ ketamine and atropine against lethality and brain damage during soman-induced status epilepticus in guinea-pigs
    Frederic Dorandeu
    Département de Toxicologie CRSSA, 24 Avenue des Maquis du Gresivaudan, La Tronche, France
    Toxicology 234:185-93. 2007
    ..IM) 30min before soman (62 microg/kg, 2 LD(50), IM), followed by therapy consisting of atropine methyl nitrate (AMN) (4 mg/kg, IM) 1min following soman exposure...
  15. pmc Unexpected sequence similarity between nucleosidases and phosphoribosyltransferases of different specificity
    A R Mushegian
    Department of Plant Pathology, University of Kentucky, Lexington 40546 0091
    Protein Sci 3:1081-8. 1994
    ..Family I consists of Escherichia coli AMP hydrolase (Amn), uridine phosphorylase (Udp), purine phosphorylase (DeoD), uncharacterized proteins from E...
  16. ncbi Cardiorespiratory effects following acute exposure to pyridostigmine bromide and/or N,N-diethyl-m-toluamide (DEET) in rats
    Leslie A Chaney
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, USA
    Int J Toxicol 21:287-300. 2002
    ..Pretreatment with atropine methyl nitrate (AMN), a peripherally selective competitive antagonist at nicotinic and muscarinic receptor sites, reduced the ..
  17. ncbi Radioprotective effect of lycopene on chromosomal aberrations (CAs) induced by gamma radiation in human lymphocytes
    Kultigin Cavusoglu
    Department of Biology, Faculty of Science and Art, University of Giresun, Giresun, Turkey
    J Environ Biol 30:113-7. 2009
    ..Mitotic index (MI) and aberrant metaphase number (AMN) were also calculated...
  18. ncbi Enhanced enteric properties and stability of shellac films through composite salts formation
    Sontaya Limmatvapirat
    Department of Pharmaceutical Technology, Silpakorn University, Nakhon Pathom, Thailand
    Eur J Pharm Biopharm 67:690-8. 2007
    ..prepared in various salt forms by dissolving them with 2-amino-2-methyl-1-propanol (AMP) and ammonium hydroxide (AMN) at various ratios of AMP:AMN...
  19. pmc Seven-Tesla proton magnetic resonance spectroscopic imaging in adult X-linked adrenoleukodystrophy
    Eva Ratai
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Neurol 65:1488-94. 2008
    ..Phenotypes vary in their pathology, ranging from axonal degeneration to inflammatory demyelination. The severity of symptoms is poorly explained by conventional imaging...
  20. doi Exploiting cell-free systems: Implementation and debugging of a system of biotransformations
    Matthias Bujara
    Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland
    Biotechnol Bioeng 106:376-89. 2010
    ..Insulation required in particular inactivation of the amn gene encoding the AMP nucleosidase, which otherwise led to glucose-independent DHAP production from adenosine ..
  21. doi Therapy of X-linked adrenoleukodystrophy
    Alexander Semmler
    University Hospital Zurich, Department of Neurology, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    Expert Rev Neurother 8:1367-79. 2008
    ..adult cerebral ALD [ACALD]) onset leading to death within a few years, over adult-onset adrenomyeloneuropathy (AMN) with or without focal CNS demyelination, AMN converting into a rapidly progressive, cerebral demyelinating ..
  22. doi Dietary starch type affects body weight and glycemic control in freely fed but not energy-restricted obese rats
    Alfred A Aziz
    Nutrition Research Division, Bureau of Nutritional Sciences, Food Directorate, Health Products and Food Branch, Health Canada, AL 2203E, Ottawa, ON, K1A 0K9, Canada
    J Nutr 139:1881-9. 2009
    ..starch diet (AMO) would improve body weight and glycemic control relative to a high-amylopectin starch diet (AMN) in rats with diet-induced obesity. After inducing obesity with a high-fat and -energy diet (Expt...
  23. ncbi The physiology of pigmented nevi
    J Kincannon
    Department of Pediatric Dermatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas
    Pediatrics 104:1042-5. 1999
    ..The common mole or acquired melanocytic nevus (AMN) is a collection of nevomelanocytes grouped into nests located in the epidermis (junctional nevus), dermis (dermal ..
  24. ncbi Should therapeutic abortion be legal in Nicaragua: the response of Nicaraguan obstetrician-gynaecologists
    Heathe Luz McNaughton
    Nicaraguan Society of Obstetrics and Gynaecology, Managua, Nicaragua
    Reprod Health Matters 10:111-9. 2002
    ..These results countered claims by the Nicaraguan Medical Association (AMN), taken up by the Church and anti-abortion legislators and groups, that therapeutic abortion was no longer ..
  25. pmc Hereditary juvenile cobalamin deficiency caused by mutations in the intrinsic factor gene
    Stephan M Tanner
    Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 102:4130-3. 2005
    ..Biallelic mutations either in the cubilin (CUBN) or amnionless (AMN) gene cause IGS...
  26. pmc Potential biomarkers of colorectal adenoma-dysplasia-carcinoma progression: mRNA expression profiling and in situ protein detection on TMAs reveal 15 sequentially upregulated and 2 downregulated genes
    Orsolya Galamb
    2nd Department of Medicine, Semmelweis University, Szentkiralyi str 46, Budapest, Hungary
    Cell Oncol 31:19-29. 2009
    ..As most colorectal cancers (CRC) develop from villous adenomas, studying alterations in gene expression profiles across the colorectal adenoma-dysplasia-carcinoma sequence may yield potential biomarkers of disease progression...
  27. ncbi The amnesiac gene product is expressed in two neurons in the Drosophila brain that are critical for memory
    S Waddell
    Center for Learning and Memory Department of Brain and Cognitive Sciences Department of Biology Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 103:805-13. 2000
    ..The predicted amnesiac gene product, AMN, is an apparent preproneuropeptide, and previous studies suggest that it stimulates cAMP synthesis...
  28. ncbi Physical organization of phytobeneficial genes nifH and ipdC in the plant growth-promoting rhizobacterium Azospirillum lipoferum 4VI
    Didier Blaha
    UMR CNRS 5557 Ecologie Microbienne, Universite Claude Bernard Lyon 1, 43 bd du 11 Novembre, 69622 Villeurbanne Cedex, France
    FEMS Microbiol Lett 244:157-63. 2005
    ..brasilense. In contrast, the region located downstream of acpD contained four housekeeping genes (i.e. genes encoding DapF-, MiaB- and FtsY-like proteins, as well as gene amn) and differed totally from the one found in A. brasilense.
  29. pmc Current and future pharmacological treatment strategies in X-linked adrenoleukodystrophy
    Johannes Berger
    Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Brain Pathol 20:845-56. 2010
    ..the clinical spectrum of the neurometabolic disorder X-linked adrenoleukodystrophy/adrenomyeloneuropathy (X-ALD/AMN)...
  30. pmc Progression of abnormalities in adrenomyeloneuropathy and neurologically asymptomatic X-linked adrenoleukodystrophy despite treatment with "Lorenzo's oil"
    B M van Geel
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 67:290-9. 1999
    ..The efficacy of "Lorenzo's oil" in the milder phenotypes of X-ALD was assessed, as this has been much less investigated...
  31. ncbi Decreased expression of ABCD4 and BG1 genes early in the pathogenesis of X-linked adrenoleukodystrophy
    Muriel Asheuer
    Institut National de la Santé et de la Recherche Médicale U561, Hopital Saint Vincent de Paul, Paris, France
    Hum Mol Genet 14:1293-303. 2005
    Childhood cerebral adrenoleukodystrophy (CCER), adrenomyeloneuropathy (AMN) and AMN with cerebral demyelination (AMN-C) are the main phenotypic variants of X-linked adrenoleukodystrophy (ALD)...
  32. doi Effect of religion on the attitude of primiparous women toward genetic testing
    Ihab M Usta
    Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
    Prenat Diagn 30:241-6. 2010
    ..Factors that influence a pregnant woman's decision to accept or decline genetic tests are largely undefined. The objective of this study was to determine the acceptance rate of prenatal diagnostic testing in Lebanon according to religion...
  33. doi General aspects and neuropathology of X-linked adrenoleukodystrophy
    Isidro Ferrer
    Institut Neuropatologia, Servei Anatomia Patològica, Institut d Investigació Biomèdica de Bellvitge IDIBELL Hospital Universitari de Bellvitge, Hospitalet de Llobregat, CIBERNED, Spain
    Brain Pathol 20:817-30. 2010
    ..recognized in male patients including cerebral ALD in childhood, adolescence or adulthood, adrenomyeloneuropathy (AMN), Addison's disease and, eventually, gonadal insufficiency...
  34. ncbi Amantadine as augmentation therapy in the management of treatment-resistant depression
    Rafael Stryjer
    Beer Yaakov Mental Health Center, Beer Yaakov, Israel
    Int Clin Psychopharmacol 18:93-6. 2003
    ..Amantadine (AMN), an agent traditionally used in the treatment and prophylaxis of influenza, is now known to exhibit prominent ..
  35. ncbi MRI and proton MRSI in women heterozygous for X-linked adrenoleukodystrophy
    A Fatemi
    Kennedy Krieger Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Neurology 60:1301-7. 2003
    ..To utilize neuroimaging procedures to assess the extent of cerebral involvement in female subjects heterozygous for X-linked adrenoleukodystrophy (X-ALD)...
  36. ncbi Natural history of X-linked adrenoleukodystrophy in Japan
    Yasuyuki Suzuki
    Medical Education Development Center, Gifu University School of Medicine, Yanagido 1 1, Gifu 501 1194, Japan
    Brain Dev 27:353-7. 2005
    ..The data on 145 patients, including 46 patients with the childhood cerebral form, 39 with adrenomyeloneuropathy (AMN), 33 with the adult cerebral form, 14 with the adolescent form and 13 with the olivo-ponto-cerebellar (OPC) form, ..
  37. doi Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy
    Stephane Fourcade
    Centre de Genètica Mèdica i Molecular, Institut d Investigació Biomèdica de Bellvitge IDIBELL, Hospitalet de Llobregat, Barcelona, Spain
    Hum Mol Genet 17:1762-73. 2008
    ..cerebral childhood adrenoleukodystrophy (CCALD) or spinal cord neurodegeneration (adrenomyeloneuropathy, AMN), adrenal insufficiency and accumulation of very long-chain fatty acids (VLCFA) in tissues...
  38. pmc Computational study of drug binding to the membrane-bound tetrameric M2 peptide bundle from influenza A virus
    Ekta Khurana
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    Biochim Biophys Acta 1808:530-7. 2011
    ..Adamantane drugs, amantadine (AMN) and rimantidine (RMN), block the proton conduction in some strains, and have been used for the treatment and ..
  39. ncbi Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters
    J Mosser
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, INSERM Unite 184, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
    Nature 361:726-30. 1993
    ..is an X-linked disease affecting 1/20,000 males either as cerebral ALD in childhood or as adrenomyeloneuropathy (AMN) in adults. Childhood ALD is the more severe form, with onset of neurological symptoms between 5-12 years of age...
  40. ncbi Influence of genetic and environmental factors on melanocytic naevi: a lesson from Turner's syndrome
    A Zvulunov
    Division of Dermatology, Medical College of Wisconsin, Milwaukee 53226, USA
    Br J Dermatol 138:993-7. 1998
    ..Although a high count of acquired melanocytic naevi (AMN) is one of the major risk factors for melanoma, this malignancy has been reported only rarely in patients with TS...
  41. ncbi An X-linked gene involved in androgenetic alopecia: a lesson to be learned from adrenoleukodystrophy
    A Konig
    Department of Dermatology, Philipp University, Marburg, Germany
    Dermatology 200:213-8. 2000
    Adrenoleukodystrophy (ALD), including its adult variant adrenomyeloneuropathy (AMN), is an X-linked recessive trait characterized by progressive demyelinization of the nervous system...
  42. ncbi Brain dysfunction explored by long latency reflex: a study of adrenomyeloneuropathy
    K K Liao
    Neurology, Neurological Institute, Taipei Veterans General Hospital, Taiwan
    Acta Neurol Scand 104:105-9. 2001
    We can assess brain function by measuring the cortical relay time (CRT) of long latency reflex (LLR) of hand muscle. We would study if measurement of CRT of LLR can explore the brain involvement of adrenomyeloneuropathy (AMN).
  43. pmc Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways
    J Yager
    Department of Biochemistry and Cell Biology, MS 140, Rice University, Houston, TX 77005, USA
    Proc Natl Acad Sci U S A 98:10445-50. 2001
    ..transporter; eag, which encodes a potassium channel; push, which encodes a large, Zn(2+)-finger-containing protein; amn, which encodes a putative neuropeptide related to the pituitary adenylate cyclase activator peptide; and NF1, the ..
  44. ncbi Adrenomyeloneuropathy, a dynamic progressive disorder: brain magnetic resonance imaging of two cases
    Yuan Heng Mo
    Department of Medical Imaging, National Taiwan University Hospital, 7 Chung Shan South Road, 100 Taipei, Taiwan
    Neuroradiology 46:296-300. 2004
    Adrenomyeloneuropathy (AMN) is a phenotype variant of X-linked adrenoleukodystrophy...
  45. ncbi Sensorimotor function and axonal integrity in adrenomyeloneuropathy
    Kathleen M Zackowski
    Kennedy Krieger Institute, The Johns Hopkins University Baltimore, MD 21205, USA
    Arch Neurol 63:74-80. 2006
    Gait abnormalities and sensorimotor disturbances are principal defects in adrenomyeloneuropathy (AMN). However, to our knowledge, their association with overall impairment and neuroanatomical changes has not been defined.
  46. ncbi Methionine metabolism and phenotypic variability in X-linked adrenoleukodystrophy
    M Linnebank
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    Neurology 66:442-3. 2006
    ..adrenoleukodystrophy, this genotype was overrepresented in a subgroup of 15 patients with adrenomyeloneuropathy (AMN) with CNS demyelination (adrenoleukomyeloneuropathy) in comparison to 49 AMN patients without CNS demyelination ("..
  47. ncbi Atropine methyl nitrate increases myenteric but not dorsal vagal complex Fos-like immunoreactivity in the rat
    Shannon J Raboin
    Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA
    Physiol Behav 88:448-52. 2006
    Atropine methyl nitrate (AMN, 0.05, 0...
  48. ncbi Nevus type in dermoscopy is related to skin type in white persons
    Iris Zalaudek
    Department of Dermatology, Medical University of Graz, Graz, Austria
    Arch Dermatol 143:351-6. 2007
    Dermoscopic classification of acquired melanocytic nevi (AMN) is based on the evaluation of 3 main criteria-global pattern, pigment distribution, and color.
  49. ncbi Evidence of in vitro differential secretion of 72 and 92 kDa type IV collagenases after selective exposure to lipopolysaccharide in human fetal membranes
    Guadalupe Garcia-Lopez
    Direction of Research, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City 11000, Mexico
    Mol Hum Reprod 13:409-18. 2007
    ..membranes form two independent chambers, allowing for the selective stimulation of either the amnion (AMN) and/or the choriodecidua (CHD) regions...
  50. ncbi Attitudes of families affected by adrenoleukodystrophy toward prenatal diagnosis, presymptomatic and carrier testing, and newborn screening
    Jean Schaller
    Myriad Genetic Laboratories, Inc, Medical Services, Salt Lake City, UT 84108, USA
    Genet Test 11:296-302. 2007
    Families affected by adrenoleukodystrophy (ALD) and adrenomyeloneuropathy (AMN) were surveyed to elicit attitudes toward prenatal, presymptomatic and carrier testing, and newborn screening in order to determine the level of support that ..
  51. doi Amnionless (AMN) mutations in Imerslund-Gräsbeck syndrome may be associated with disturbed vitamin B12 transport into the CNS
    A S Luder
    Department of Paediatrics, Ziv Medical Center, Safed and Faculty of Medicine, Technion, Haifa, Israel
    J Inherit Metab Dis 31:493-6. 2008
    ..Mutations in the amnionless (AMN) and cubilin (CUBN) genes are known to be causes of IGS...
  52. doi Cholesterol-deprivation increases mono-unsaturated very long-chain fatty acids in skin fibroblasts from patients with X-linked adrenoleukodystrophy
    M Engelen
    Academic Medical Center, University of Amsterdam, Laboratory Genetic Metabolic Diseases, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Biochim Biophys Acta 1781:105-11. 2008
    ..and fatal cerebral demyelinating disease in childhood (CCALD), to the milder slowly progressive form in adulthood (AMN)...
  53. doi Tasigna for chronic and accelerated phase Philadelphia chromosome--positive chronic myelogenous leukemia resistant to or intolerant of imatinib
    Maitreyee Hazarika
    Office of Oncology Drug Products, Office of New Drugs, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland 20993, USA
    Clin Cancer Res 14:5325-31. 2008
    ..FDA) approval report describes the data and analyses leading to the approval by the FDA of nilotinib (Tasigna, AMN-107; Novartis Pharmaceuticals Corporation), an inhibitor of Bcr-Abl tyrosine kinase, for the treatment of chronic-..
  54. doi Histogenesis of congenital and acquired melanocytic nevi based on histological study of lesion size and thickness
    Yasutaka Tokuda
    Division of Dermatology, National Mastumoto Medical Center, Murai chyo, Matsumoto, Japan
    J Dermatol 37:1011-8. 2010
    ..To clarify the histogenic differences between acquired melanocytic nevi (AMN) and congenital melanocytic nevi (CMN), diameter and depth of nevus cells (tumor thickness) were examined in ..
  55. doi Evidence of in vitro differential secretion of human beta-defensins-1, -2, and -3 after selective exposure to Streptococcus agalactiae in human fetal membranes
    Veronica Zaga-Clavellina
    Department of Cell Biology, Instituto Nacional de Perinatologia, Mexico City, Mexico
    J Matern Fetal Neonatal Med 25:358-63. 2012
    The aim of this work was to characterize the individual contribution of the amnion (AMN) and choriodecidua (CHD) regions to the secretion of human beta defensins (HBD)-1, -2, and -3, after stimulation with Streptococcus agalactiae.
  56. doi Reproductive function in men affected by X-linked adrenoleukodystrophy/adrenomyeloneuropathy
    T J Stradomska
    Department of Biochemistry and Experimental Medicine, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsaw, Poland
    Eur J Endocrinol 166:291-4. 2012
    ..X-linked adrenoleukodystrophy (X-ALD) is the most frequent, severely neurodegenerative, clinically heterogeneous peroxisomal disorder, the signs of which are a consequence of myelin, adrenal cortex, and testes impairment...
  57. doi Detection of melamine in infant formula and grain powder by surface-assisted laser desorption/ionization mass spectrometry
    Yi Ting Hsieh
    Department of Chemistry, National Taiwan University, Taipei, Taiwan
    Rapid Commun Mass Spectrom 26:1393-8. 2012
    We have developed a method for the determination of melamine (MEL), ammeline (AMN), and ammelide (AMD) by surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using gold nanoparticles (Au NPs)...
  58. pmc Tissue-specific human beta-defensins (HBD)-1, HBD-2 and HBD-3 secretion profile from human amniochorionic membranes stimulated with Candida albicans in a two-compartment tissue culture system
    Veronica Zaga-Clavellina
    Department of Cell Biology, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico
    Reprod Biol Endocrinol 10:70. 2012
    ..The aim of this work was to characterize the individual contribution of the amnion (AMN) and choriodecidua (CHD) regions to the secretion of HBD-1, HBD-2 and HBD-3, after stimulation with Candida albicans...
  59. doi Vitamin B12 absorption: mammalian physiology and acquired and inherited disorders
    Renata Kozyraki
    INSERM, U968, Paris F 75012, France
    Biochimie 95:1002-7. 2013
    ..Disturbed cellular entry, transit or egress of vitamin B12 may lead to low vitamin B12 status or deficiency and eventually hematological and neurological disorders...
  60. pmc Cubilin and amnionless mediate protein reabsorption in Drosophila nephrocytes
    Fujian Zhang
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Am Soc Nephrol 24:209-16. 2013
    ..required for nephrocyte function and identified two Drosophila genes encoding orthologs of mammalian cubilin and amnionless (AMN), two major receptors for protein reabsorption in the proximal tubule...
  61. pmc A Novel Double Mutation in the ABCD1 Gene in a Patient with X-linked Adrenoleukodystrophy: Analysis of the Stability and Function of the Mutant ABCD1 Protein
    Masashi Morita
    Department of Biological Chemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, Japan
    JIMD Rep 10:95-102. 2013
    We diagnosed an adrenomyeloneuropathy (AMN) patient with a double novel missense mutation, c.284C>A (p.A95D) and c.290A>T (p.H97L) in a single ABCD1 allele...
  62. doi Mass balance of anti-influenza drugs discharged into the Yodo River system, Japan, under an influenza outbreak
    Takashi Azuma
    Research Center for Environmental Quality Management, Graduate School of Engineering, Kyoto University, 1 2 Yumihama, Otsu, Shiga 520 0811, Japan Electronic address
    Chemosphere 93:1672-7. 2013
    ..of the mass balances of four anti-influenza drugs-oseltamivir (OS), oseltamivir carboxylate (OC), amantadine (AMN), and zanamivir (ZAN)-in the urban area of the Yodo River system...
  63. pmc Imerslund-Gräsbeck syndrome in a 25-month-old Italian girl caused by a homozygous mutation in AMN
    Gianpaolo De Filippo
    Servizio di Endocrinologia Pediatrica, AORN Gaetano Rummo, Benevento, Italy
    Ital J Pediatr 39:58. 2013
    ..We report for the first time the case of a girl of Italian ancestry with IGS genetically confirmed by the detection of a homozygous missense mutation in the AMN gene (c.208-2 A > G).
  64. doi Assessment of vascularity in common blue nevi, small/medium congenital nevocellular, common and dysplastic acquired melanocytic nevi and melanomas: a comparative study
    Eleftherios N Ioannidis
    Department of Dermatopathology, National and Kapodistrian University of Athens, Athens, Greece
    Am J Dermatopathol 36:217-22. 2014
    ..congenital nevocellular nevi (CN), common blue nevi (BN), common and dysplastic acquired melanocytic nevi (AMN), and melanomas. The authors collected 31 BN, 48 CN (≤5 cm), 35 AMN (14 common, 21 dysplastic), and 26 melanomas...
  65. doi Loss of AMP-activated protein kinase in X-linked adrenoleukodystrophy patient-derived fibroblasts and lymphocytes
    Jaspreet Singh
    Department of Neurology, Henry Ford Health System, Detroit, MI 48202, United States Electronic address
    Biochem Biophys Res Commun 445:126-31. 2014
    ..and lymphocytes of the severe cerebral form of X-ALD (ALD), and not in the milder adrenomyeloneuropathy (AMN) form. Decrease in AMPK was observed at both protein and mRNA levels...
  66. ncbi [Analysis on pathology features and prognosis of appendiceal mucinous neoplasm]
    Mei Zhang
    Department of Pathology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China
    Zhonghua Wei Chang Wai Ke Za Zhi 17:65-70. 2014
    To explore the pathological features and prognosis of appendiceal mucinous neoplasms (AMN) based on WHO classification 2010.
  67. doi Apoptotic cells subjected to cold/warming exposure disorganize apoptotic microtubule network and undergo secondary necrosis
    Manuel Oropesa-Avila
    Centro Andaluz de Biologia del Desarrollo CABD, Consejo Superior de Investigaciones Cientificas CSIC, Universidad Pablo de Olavide, and Centro de Investigación Biomédica en Red Enfermedades Raras, Instituto de Salud Carlos III, Carretera de Utrera Km 1, 41013, Seville, Spain
    Apoptosis 19:1364-77. 2014
    Apoptotic microtubule network (AMN) is organized during apoptosis, forming a cortical structure beneath the plasma membrane which plays a critical role in preserving cell morphology and plasma membrane integrity...
  68. doi Synergistic and antagonistic effect of lactic acid bacteria on tyramine production by food-borne pathogenic bacteria in tyrosine decarboxylase broth
    Esmeray Kuley
    Department of Seafood Processing Technology, Faculty of Fisheries, Cukurova University, 01330 Balcali, Adana, Turkey Electronic address
    Food Chem 127:1163-8. 2011
    ..Significant differences were observed among the FBP strains in ammonia (AMN) and BA production apart from tryptamine, histamine (HIS) and spermine formation (p<0.05)...
  69. doi Exploiting supramolecular synthons in designing gelators derived from multiple drugs
    Rajdip Roy
    Department of Organic Chemistry, Indian Association for the Cultivation of Science IACS, 2A and 2B, Raja S C Mullick Road, Jadavpur, Kolkata 700032, West Bengal India, Fax 91 33 2473 2805
    Chemistry 20:15320-4. 2014
    ..supramolecular gelators comprised of various nonsteroidal anti-inflammatory drugs (NSAIDs) and amantadine (AMN) (an antiviral drug) has been demonstrated using a supramolecular synthon approach...
  70. doi The influence of the cell free solution of lactic acid bacteria on tyramine production by food borne-pathogens in tyrosine decarboxylase broth
    Nurten Toy
    Vocational School of Feke, Cukurova University, 01660 Feke, Adana, Turkey
    Food Chem 173:45-53. 2015
    ..inhibitor effect since lactic acid inhibited microbial growth, decreased pH quickly and reduced the formation of AMN and BAs...
  71. doi Magnetically optimized SERS assay for rapid detection of trace drug-related biomarkers in saliva and fingerprints
    Tianxi Yang
    The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors and Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China
    Biosens Bioelectron 68:350-7. 2015
    ..In this paper, Au nanoparticles dotted magnetic nanocomposites (AMN) modified with inositol hexakisphosphate (IP6) were used as surface-enhanced Raman scattering (SERS) substrate to ..
  72. doi Emerging roles of apoptotic microtubules during the execution phase of apoptosis
    Manuel Oropesa Avila
    Centro Andaluz de Biologia del Desarrollo CABD, and Centro de Investigación Biomédica en Red Enfermedades Raras, Instituto de Salud Carlos III, Universidad Pablo de Olavide Consejo Superior de Investigaciones Científicas, Sevilla, 41013, Spain
    Cytoskeleton (Hoboken) 72:435-46. 2015
    ..that microtubules are reformed during the execution phase of apoptosis organizing an apoptotic microtubule network (AMN). AMN is organized behind plasma membrane, forming a cortical structure...
  73. pmc Functional Characterization of IPSC-Derived Brain Cells as a Model for X-Linked Adrenoleukodystrophy
    Mauhamad Baarine
    Department of Pediatrics, Children s Research Institute, Medical University of South Carolina, Charleston, South Carolina, United States of America
    PLoS ONE 10:e0143238. 2015
    ..phenotypes: the fatal disorder of cerebral childhood ALD (cALD) or a milder disorder of adrenomyeloneuropathy (AMN)...
  74. doi Dermoscopic and Immunohistochemical Changes in Acquired Melanocytic Nevi following Narrow-Band Ultraviolet B Therapy
    Hesham Zaher
    Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt
    Dermatology 232:273-8. 2016
    Acquired melanocytic nevi (AMN) have been reported to undergo morphological and dermoscopic changes following exposure to narrow-band ultraviolet B (NB-UVB) radiation.
  75. doi Influence of urothelial or suburothelial cholinergic receptors on bladder reflexes in chronic spinal cord injured cats
    Timothy D Ungerer
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Exp Neurol 285:147-158. 2016
    ..administration of a muscarinic receptor agonist (oxotremorine-M, OXO-M) and antagonist (atropine methyl nitrate, AMN) and of a nicotinic receptor agonist (nicotine) and antagonist (hexamethonium, C6) on reflex bladder ..
  76. ncbi Ultimate Clinical Outcomes of Appendiceal Mucinous Neoplasm of Uncertain Malignant Potential
    Rumi Shin
    Department of Surgery, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea
    Ann Surg Oncol . 2016
    The clinical outcome of appendiceal mucinous neoplasm (AMN) is not well understood...
  77. ncbi Deletion mapping of the Drosophila memory mutant amnesiac
    T Tully
    J Neurogenet 3:33-47. 1986
    ..conditioning procedure, two deficiency chromosomes, mal8 and mal12, produced amnesiac-like memory deficits in Df/amn flies but not in Df/ + controls...
  78. ncbi Comparative studies of four Drosophila P-insertion mutants with memory defects
    Yu V Bragina
    Laboratory for Comparative Behavioral Genetics, I P Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034 St Petersburg, Russia
    Neurosci Behav Physiol 33:73-9. 2003
    ..e., the association between the conditioned and unconditioned stimuli (lat, rut, dnc, amn, and P153) and the association between the conditioned stimulus and the aversive motivational system mediating the ..
  79. ncbi Identification of 20 genes aberrantly methylated in human breast cancers
    Kazuaki Miyamoto
    Carcinogenesis Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Int J Cancer 116:407-14. 2005
    ..HOXD11, FLJ25161, XT3, PCDH10, PCDHGB6, SIM1, LOC346978, COE2, TDH (FLJ25033), LOC346419, FLJ33790, GJB2, AMN, LOC201164, DLX4, DCC and FOXA2, were found to be methylated in at least one of 8 breast cancer cell lines...
  80. ncbi Academia Multidisciplinaria Neurotraumatologica AMN
    K R H von Wild
    Medical Faculty, Westfälischen Wilhelms University, Munster, North Rhine Westphalia, Germany
    Acta Neurochir Suppl 93:223-6. 2005
  81. ncbi Homozygous AMN mutation in hereditary selective intestinal malabsorption of vitamin B12 in Jordan
    Jamil R Al-Alami
    Department of Biochemistry and Medical Laboratory Science, Jordan University of Science and Technology, Irbid, Jordan
    Saudi Med J 26:1061-4. 2005
    ..Several syndromes present with megaloblastic anemia such as congenital megaloblastic anemia due to intrinsic factor defect and juvenile megaloblastic anemia with proteinuria due to defects in the cubilin or the amnionless protein.
  82. ncbi Auditory brainstem response findings and peripheral auditory sensitivity in adrenoleukodystrophy
    J P Pillion
    Kennedy Krieger Institute, MD 21205, USA
    J Neurol Sci 247:130-7. 2006
    ..The five groups were cerebral childhood and adolescent, pure adrenomyeloneuropathy (pure AMN), adrenomyeloneuropathy cerebral (AMN cerebral), Addison's only and symptomatic female heterozygotes...
  83. ncbi Molecular cloning and characterization of Mn-superoxide dismutase from disk abalone (Haliotis discus discus)
    Prashani Mudika Ekanayake
    Department of Marine Biotechnology, Cheju National University, 66 Jejudaehakno, Jeju 690 756, Republic of Korea
    Comp Biochem Physiol B Biochem Mol Biol 145:318-24. 2006
    ..In this study, a putative gene encoding Mn-SOD from disk abalone (Haliotis discus discus, aMn-SOD) was cloned, sequenced, expressed in Escherichia coli K12(TB1) and the protein was purified using pMAL protein ..
  84. pmc Determination of MICs of aminocandin for Candida spp. and filamentous fungi
    N Isham
    Center for Medical Mycology, University Hospitals of Cleveland Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    J Clin Microbiol 44:4342-4. 2006
    ..We evaluated the new echinocandin aminocandin (AMN) for its antifungal activities against a range of fungal pathogens by determination of the MICs for the organisms...
  85. pmc Repeated administration of imipramine modifies GABAergic transmission in rat frontal cortex
    Joanna Wabno
    Department of Physiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    J Neural Transm (Vienna) 120:711-9. 2013
    ..Application of N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride (AMN 082), a selective mGluR7 allosteric agonist, to the slice incubation medium resulted in a decrease in the mean ..
  86. ncbi [X-linked adrenoleukodystrophy--case reports of 4 patients in a family]
    Miroslav Dumic
    Klinicki bolnicki centar Zagreb
    Lijec Vjesn 124:258-62. 2002
    ..from three generations showed three patients with adrenoleukodystrophy (ALD), one with adrenomyeloneuropathy (AMN) and five females heterozygous for ALD, three of which were psychiatric patients...
  87. pmc A-, T-, and H-type currents shape intrinsic firing of developing rat abducens motoneurons
    Michael Russier
    Neurobiologie des Canaux Ioniques, INSERM U464, IFR Jean Roche, Faculte de Medecine Nord, Universite de la Mediterranee, Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France
    J Physiol 549:21-36. 2003
    ..Recordings were made from aMNs in the whole-cell configuration of the patch-clamp technique. Two main types of aMn could be distinguished according to their firing profile during prolonged depolarizations...
  88. doi Accessory mental nerve: case report, review and its role in trigeminal neuralgia
    Anjani Kumar Jha
    Neelam s Faciomaxillary and Dental Care Centre, 661 8th Main Road, Hampinagar, Bangalore, Karnataka, India
    Surg Radiol Anat 34:469-73. 2012
    The presence of accessory mental nerve (AMN) is rare and only few cases have been reported. Peripheral neurectomy of the mental nerve is one of the treatments of choice in cases of trigeminal neuralgia (TGN) affecting the mental nerve...
  89. doi Comparison of three methods for detection of melamine in compost and soil
    Yongqiang Tian
    Depatment of Vegetable Science, College of Agronomy and Biotechnology, China Agricultural University, 2 Yuanmingyuan xilu, Beijing 100193, China
    Sci Total Environ 417:255-62. 2012
    ..All three methods accurately detected MM concentrations if no MM degradation products, such as ammeline (AMN), ammelide (AMD) and cyanuric acid (CA), were present in an aqueous sample...
  90. doi X-linked adrenoleukodystrophy: clinical, metabolic, genetic and pathophysiological aspects
    Stephan Kemp
    Department of Clinical Chemistry, University of Amsterdam, The Netherlands
    Biochim Biophys Acta 1822:1465-74. 2012
    ..The two main clinical phenotypes of X-ALD are adrenomyeloneuropathy (AMN) and inflammatory cerebral ALD that manifests either in children or more rarely in adults...
  91. doi Strength: a relevant link to functional performance in the neurodegenerative disease of adrenomyeloneuropathy
    Jennifer L Keller
    Kennedy Krieger Institute, Baltimore, MD, USA
    Neurorehabil Neural Repair 26:1080-8. 2012
    With progressive abnormalities in leg strength, tone, and sensation, adrenomyeloneuropathy (AMN) is a differential diagnosis for multiple sclerosis and hereditary spastic paraparesis...
  92. doi How can cobalamin injections be spaced in long-term therapy for inborn errors of vitamin B(12) absorption?
    Amina Boina Abdallah
    APHP, Reference Center for Inherited Metabolic Disease, Hopital Robert Debre, F 75019 Paris, France
    Mol Genet Metab 107:66-71. 2012
    ..IGD is due to mutations in one of the 2 subunits of the intrinsic factor receptor that is cubilin (CUBN) or amnionless (AMN)...
  93. pmc Intravenous immunoglobulin treatment in a patient with adrenomyeloneuropathy
    Aia Elise Jønch
    Kennedy Centre, Copenhagen University Hospital, Rigshospitalet, GL, Landevej 7, Copenhagen, 2600, Glostrup, Denmark
    BMC Neurol 12:108. 2012
    Adrenomyeloneuropathy (AMN) is one of several phenotypes of the adrenoleukodystrophy spectrum caused by mutations in the ABCD1 gene on the X chromosome...
  94. pmc Increased macular choroidal blood flow velocity during systemic corticosteroid therapy in a patient with acute macular neuroretinopathy
    Yuki Hashimoto
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Ophthalmol 6:1645-9. 2012
    The precise mechanism causing outer retinal damage in acute macular neuroretinopathy (AMN) remains unclear...
  95. ncbi Structure and regulation of the AMP nucleosidase gene (amn) from Escherichia coli
    H B Leung
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania
    Biochemistry 28:8726-33. 1989
    The gene for AMP nucleosidase from Escherichia coli (amn) has been sequenced and characterized. The gene codes for a transcript of 1.7 +/- 0.2 kb, and the open reading frame corresponds to a protein of 483 amino acids (Mr = 53848)...
  96. pmc Mutations in the gene for X-linked adrenoleukodystrophy in patients with different clinical phenotypes
    A Braun
    Department of Pediatrics, University of Munich, Germany
    Am J Hum Genet 56:854-61. 1995
    ..X-ALD and in their female relatives; these clinical expressions were cerebral childhood ALD, adrenomyeloneuropathy (AMN), and "Addison disease only" (ADO) phenotype...
  97. ncbi A neuropeptide gene defined by the Drosophila memory mutant amnesiac
    M B Feany
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Science 268:869-73. 1995
    ..One suppressor mutation that was recovered mapped in the amnesiac (amn) gene. Cloning of the locus revealed that amn encodes a previously uncharacterized neuropeptide gene...
  98. ncbi A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein
    X Wang
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021, USA
    Dev Biol 177:274-90. 1996
    We report the identification of a new recessive prenatal lethal insertional mutation, amnionless (amn). amn mutant embryos first appear abnormal during the Early Streak stage, between E6.5 and E7.0, when they initiate mesoderm production...
  99. ncbi [Phenotype variability in adrenoleukodystrophy. Presentation of three new cases and a review of literature]
    J R Ara
    , Zaragoza
    Rev Neurol 24:843-7. 1996
    ..disorder with very variable phenotype expression, including classical infantil ALD, adrenomyeloneuropathy (AMN) in adults and sex-linked Addison's disease. Clinical observations. Three affected patients are presented...
  100. ncbi Cloning and analysis of the shiA gene, which encodes the shikimate transport system of escherichia coli K-12
    M J Whipp
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, 3052, Australia
    Gene 209:185-92. 1998
    ..The gene is predicted to encode a protein of 438 amino acids and lies adjacent to the amn gene...
  101. ncbi Differences in developmental cell death between somatic and autonomic motor neurons of rat spinal cord
    R Wetts
    Division of Neurosciences, Beckman Research Institute of the City of Hope, Duarte, California 91010 3011, USA
    J Comp Neurol 396:483-92. 1998
    ..In the present study, we used three different approaches to determine the amount of AMN cell death during normal development in the rat...

Research Grants13

  1. Imaging the Pathophysiology of AMN in Mice and Humans
    Florian S Eichler; Fiscal Year: 2010
    ..candidate to further develop his knowledge of MR physics and expertise in imaging studies of adrenomyeloneuropathy (AMN), a form of adrenoleukodystrophy (ALD), while providing rigorous exposure to the clinical and biological side of ..
  2. Functional Studies in Adrenomyeloneuropathy
    Gerald Raymond; Fiscal Year: 2005
    ..In affected men, AMN presents most commonly in the late twenties as a spastic paraparesis that is progressive over decades and often ..
  3. A Phase III Trial of Lorenzo's Oil in Adrenomyeloneuropathy
    Gerald Raymond; Fiscal Year: 2009
    ..study of glyceryl trioleate-glyceryl trierucate (Lorenzo's Oil or LO) therapy in adrenomyeloneuropathy (AMN), the adult form of X-linked adrenoleukodystrophy (X-ALD)...
  4. Cell Growth and Differentiation in the Vetebrate Embryo
    Elizabeth Lacy; Fiscal Year: 2005
    ..The mouse mutation amnionless (amn) not only impairs epiblast growth, but also specifically disrupts the assembly and/or function of the ..
  5. noso and primitive streak function in mouse gastrulation
    Floria Lupu; Fiscal Year: 2004
    ..One of these, amn (amnionless), was previously characterized by the Lacy lab, which recently cloned the Amn gene...
  6. Mechanisms and significance of cublin-mediated HDL uptake
    WILLIAM ARGRAVES; Fiscal Year: 2009
    ..The second aim is to determine the significance of each of the three known cubilin co-receptors, megalin, amnionless (AMN) and the cation-independent mannose 6-phosphate/insulin-like growth factor ll-receptor (CIMPR), to the ..
  7. SIGNALLING WITHIN THE DROSOPHILA SEGMENTAL NERVE
    Michael Stern; Fiscal Year: 2004
    ..intermediates in the receipt of intercellular signaling pathways mediated by the PACAP neuropeptide, or by the amn-encoded protein, which is PACAP-related...
  8. MRNA EXPORT FROM THE NUCLEUS OF SACCHAROMYCES CEREVISIAE
    ALAN TARTAKOFF; Fiscal Year: 1993
    The goal is to characterize available temperature-sensitive mutants of Saccharomyces cerevisiae (amn mutants) which accumulate polyA+ mRNA in the nucleus at 37oC. These mutants fall into eleven complementation groups...
  9. Adolescent Nicotine Exposure and Adult Cognitive Processes in Rats
    STEPHEN FOUNTAIN; Fiscal Year: 2008
    ..The results will also provide new information regarding the important public health question of the extent to which adolescent nicotine exposure is a threat to adult cognitive capacity. [unreadable] [unreadable] [unreadable] [unreadable]..
  10. Niacin Sensitivity and Fatty Acids in Schizophrenia
    Erik Messamore; Fiscal Year: 2005
    ..niacin sensitivity by measuring the skin blood flow response to graded doses of topical alpha-methylnicotinate (AMN)...
  11. Transdisciplinary Imaging Genetics Center (1 of 2)(RMI)
    Steven Potkin; Fiscal Year: 2006
    ..The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness. [unreadable] [unreadable]..