alpha fetoprotein

Summary

Gene Symbol: alpha fetoprotein
Description: alpha fetoprotein
Alias: AFPD, FETA, HPAFP, alpha-fetoprotein, alpha-1-fetoprotein, alpha-fetoglobulin
Species: human

Top Publications

  1. ncbi Hepatocellular carcinoma (HCC) and diagnostic significance of A-fetoprotein (AFP)
    Jawed Altaf Baig
    Department of Biochemistry, Liaquat National Medical College, Karachi, Pakistan
    J Ayub Med Coll Abbottabad 21:72-5. 2009
  2. pmc Expression and location of alpha-fetoprotein during rat colon development
    Xiao Yan Liu
    Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu Province, China
    World J Gastroenterol 15:1738-43. 2009
  3. ncbi Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: characterization of a negative hypoxia response element that mediates opposite effects of hypoxia inducible factor-1 and c-Myc
    Nathalie M Mazure
    Centre de recherche sur l Endocrinologie Moleculaire et le Developpement, CNRS UPR 9078, 92190 Meudon Bellevue, France
    Cancer Res 62:1158-65. 2002
  4. ncbi Oncodevelopmental alpha-fetoprotein acts as a selective proangiogenic factor on endothelial cell from the fetomaternal unit
    Olin D Liang
    Department of Obstetrics and Gynecology, Justus Liebig University, D 35385 Giessen, Germany
    J Clin Endocrinol Metab 89:1415-22. 2004
  5. pmc Alpha-fetoprotein stimulated the expression of some oncogenes in human hepatocellular carcinoma Bel 7402 cells
    Meng Sen Li
    Department of Biochemistry, Hainan Medical College, Haikou 571101, China
    World J Gastroenterol 10:819-24. 2004
  6. ncbi Alpha-fetoprotein impairs APC function and induces their apoptosis
    Soon Ho Um
    Institute of Hepatology, University College London, United Kingdom
    J Immunol 173:1772-8. 2004
  7. doi Clinical significance of alpha-fetoprotein: involvement in proliferation, angiogenesis, and apoptosis of hepatocellular carcinoma
    Noboru Mitsuhashi
    Section for Medical Nanotechniques, Research Center for Frontier Medical Engineering, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 23:e189-97. 2008
  8. doi Silencing alpha-fetoprotein expression induces growth arrest and apoptosis in human hepatocellular cancer cell
    Xiaojun Yang
    Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu, China
    Cancer Lett 271:281-93. 2008
  9. doi Prognostic values of alpha-fetoprotein and protein induced by vitamin K absence or antagonist-II in hepatitis B virus-related hepatocellular carcinoma: a prospective study
    Hyoung Su Kim
    Department of Internal Medicine, Kangdong Sacred Heart Hospital of Hallym University Medical Center, Seoul, Republic of Korea
    J Clin Gastroenterol 43:482-8. 2009
  10. pmc Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma
    Jorge A Marrero
    University of Michigan, Ann Arbor, Michigan 48109, USA
    Gastroenterology 137:110-8. 2009

Research Grants

  1. AFP-Based Immunotherapy for Hepatocellular Carcinoma
    Antoni Ribas; Fiscal Year: 2006
  2. Radoslav Goldman; Fiscal Year: 2016
  3. Fate-mapping temporally marked precursor populations to hepatocellular carcinoma
    Hyam L Leffert; Fiscal Year: 2013
  4. Development of a Urine Test for the Early Detection of Liver Cancer
    Wei Song; Fiscal Year: 2012
  5. Pregnancy Hormonal Profile/Biomarker Breast Cancer Risk
    Alan Arslan; Fiscal Year: 2004
  6. Brett T Spear; Fiscal Year: 2015
  7. In Vitro Reconstitution of Alpha Fetroprotein Regulation
    Michelle Barton; Fiscal Year: 2007
  8. REGULATION OF ALPHA-FETOPROTEIN GENE EXPRESSION
    Shirley Tilghman; Fiscal Year: 1993
  9. LARGE DELETION ADENOVIRAL VECTORS FOR CYSTIC FIBROSIS
    WANDA O NEAL; Fiscal Year: 1999
  10. Genetic Immunotherapy for Hepatocellular Cancer
    James Economou; Fiscal Year: 2004

Detail Information

Publications547 found, 100 shown here

  1. ncbi Hepatocellular carcinoma (HCC) and diagnostic significance of A-fetoprotein (AFP)
    Jawed Altaf Baig
    Department of Biochemistry, Liaquat National Medical College, Karachi, Pakistan
    J Ayub Med Coll Abbottabad 21:72-5. 2009
    ....
  2. pmc Expression and location of alpha-fetoprotein during rat colon development
    Xiao Yan Liu
    Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu Province, China
    World J Gastroenterol 15:1738-43. 2009
    ..To investigate the expression of alpha-fetoprotein (AFP), a cancer-associated fetal glycoprotein, and its involvement during rat colon development...
  3. ncbi Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: characterization of a negative hypoxia response element that mediates opposite effects of hypoxia inducible factor-1 and c-Myc
    Nathalie M Mazure
    Centre de recherche sur l Endocrinologie Moleculaire et le Developpement, CNRS UPR 9078, 92190 Meudon Bellevue, France
    Cancer Res 62:1158-65. 2002
    ..Taken together, these results suggest the existence of a possible competition between HIF-1 and c-Myc that could modulate the transcriptional activity of the afp gene in response to hypoxia...
  4. ncbi Oncodevelopmental alpha-fetoprotein acts as a selective proangiogenic factor on endothelial cell from the fetomaternal unit
    Olin D Liang
    Department of Obstetrics and Gynecology, Justus Liebig University, D 35385 Giessen, Germany
    J Clin Endocrinol Metab 89:1415-22. 2004
    ..These data indicate that AFP may act as a specific proangiogenic factor of endothelial cells within the fetomaternal unit during advanced stages in pregnancy...
  5. pmc Alpha-fetoprotein stimulated the expression of some oncogenes in human hepatocellular carcinoma Bel 7402 cells
    Meng Sen Li
    Department of Biochemistry, Hainan Medical College, Haikou 571101, China
    World J Gastroenterol 10:819-24. 2004
    ..To investigate the molecular mechanism of alpha-fetoprotein (AFP) on regulating the proliferation of human hepatocellular carcinoma cells...
  6. ncbi Alpha-fetoprotein impairs APC function and induces their apoptosis
    Soon Ho Um
    Institute of Hepatology, University College London, United Kingdom
    J Immunol 173:1772-8. 2004
    ..In conclusion, these results illustrate that AFP induces dysfunction and apoptosis of APCs, thereby offering a mechanism by which HCC escapes immunological control...
  7. doi Clinical significance of alpha-fetoprotein: involvement in proliferation, angiogenesis, and apoptosis of hepatocellular carcinoma
    Noboru Mitsuhashi
    Section for Medical Nanotechniques, Research Center for Frontier Medical Engineering, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 23:e189-97. 2008
    ..However, there have been few reports on the reasons for poor prognosis...
  8. doi Silencing alpha-fetoprotein expression induces growth arrest and apoptosis in human hepatocellular cancer cell
    Xiaojun Yang
    Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu, China
    Cancer Lett 271:281-93. 2008
    ..As such, the knockdown of AFP gene should be further investigated in vivo as a novel approach to HCC treatment...
  9. doi Prognostic values of alpha-fetoprotein and protein induced by vitamin K absence or antagonist-II in hepatitis B virus-related hepatocellular carcinoma: a prospective study
    Hyoung Su Kim
    Department of Internal Medicine, Kangdong Sacred Heart Hospital of Hallym University Medical Center, Seoul, Republic of Korea
    J Clin Gastroenterol 43:482-8. 2009
    ..However, prognostic values of AFP and PIVKA-II remain clarified in hepatitis B virus (HBV)-associated HCC. This study was aimed to evaluate the prognostic values of AFP and PIVKA-II in HBV-associated HCC...
  10. pmc Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma
    Jorge A Marrero
    University of Michigan, Ann Arbor, Michigan 48109, USA
    Gastroenterology 137:110-8. 2009
    ..The aims of this study were to determine performance of DCP and AFP-L3% for the diagnosis of early HCC; whether they complement AFP; and what factors affect DCP, AFP-L3%, or AFP levels...
  11. doi Clinical significance of the highly sensitive fucosylated fraction of α-fetoprotein in patients with chronic liver disease
    Takuya Hanaoka
    Department of Gastroenterology and Hepatology, Shimane University, Faculty of Medicine, Izumo, Japan
    J Gastroenterol Hepatol 26:739-44. 2011
    ....
  12. doi Early α-fetoprotein response as a predictor for clinical outcome after localized concurrent chemoradiotherapy for advanced hepatocellular carcinoma
    Beom Kyung Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seodaemun gu, Seoul, Korea
    Liver Int 31:369-76. 2011
    ..There are limitations in using only radiological criteria to evaluate treatment outcomes in hepatocellular carcinoma (HCC). α-fetoprotein (AFP) is regarded as an indicator of tumour activity in HCC...
  13. doi Early on-treatment predictions of clinical outcomes using alpha-fetoprotein and des-gamma-carboxy prothrombin responses in patients with advanced hepatocellular carcinoma
    Myoung Ha Lee
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 27:313-22. 2012
    ....
  14. doi Early decrease in α-fetoprotein, but not des-γ-carboxy prothrombin, predicts sorafenib efficacy in patients with advanced hepatocellular carcinoma
    Teiji Kuzuya
    Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Tokyo, Japan
    Oncology 81:251-8. 2011
    ....
  15. doi Combined measurement of preoperative α-fetoprotein and des-γ-carboxy prothrombin predicts recurrence after curative resection in patients with hepatitis-B-related hepatocellular carcinoma
    Young Eun Chon
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Int J Cancer 131:2332-41. 2012
    ..The combined measurement of preoperative AFP and DCP may be a prognostic factor for future recurrence...
  16. pmc Prognostic value of α-fetoprotein and des-γ-carboxy prothrombin responses in patients with hepatocellular carcinoma treated with transarterial chemoembolization
    Yong Kang Lee
    Department of Internal Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul 120 752, Korea
    BMC Cancer 13:5. 2013
    ..However, prediction of outcome using AFP and DCP has not been elucidated. We investigated the clinical role of AFP and DCP as predictors of treatment outcome in patients with HCC undergoing trans-arterial chemoembolization (TACE)...
  17. pmc Primary structures of human alpha-fetoprotein and its mRNA
    T Morinaga
    Proc Natl Acad Sci U S A 80:4604-8. 1983
    ..Again, the similarity was the highest in domain 3 and the lowest in domain 1. Human AFP and human albumin are similar in overall structure, but certain parts of the molecules differ significantly in their predicted secondary structure...
  18. pmc The refolding of different alpha-fetoprotein variants
    Susanna S J Leong
    Centre for Biomolecular Engineering, The University of Queensland, St Lucia, Australia
    Protein Sci 15:2040-50. 2006
    ....
  19. pmc alpha-Fetoprotein as a modulator of the pro-inflammatory response of human keratinocytes
    A I Potapovich
    Lab Tissue Engineering and Skin Pathophysiology, Dermatology Institute Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    Br J Pharmacol 158:1236-47. 2009
    ..We examined the effects of embryonic and recombinant human AFP on the spontaneous, UVA- and cytokine-induced pro-inflammatory responses of human keratinocytes...
  20. ncbi Immunoelectrophoretic differentiation of alpha-fetoprotein in disorders with elevated serum alpha-fetoprotein levels or during pregnancy
    R J Chen
    Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei
    Acta Oncol 34:931-5. 1995
    ..Chronic hepatitis had a light L1 band and a pronounced L3 band. In pregnancy, the AFP pattern is similar to that of hepatocellular carcinoma. Immunoelectrophoresis is a useful method facilitating the differentiation of AFP origins...
  21. ncbi Targeted chemotherapy for unresectable primary and metastatic liver cancer
    T Konno
    First Department of Surgery, Kumamoto University School of Medicine, Japan
    Acta Oncol 33:133-7. 1994
    ..In the 110 patients with metastatic liver cancer, the carcinoembryonic antigen level and tumor size were reduced. The 1-, 2-, and 5-year survival rates of these 110 patients were 61, 32, and 22% respectively...
  22. ncbi Serum tumor markers for detection of bone metastasis in breast cancer patients
    A Aydiner
    Dept. of Medical Oncology, Istanbul Faculty of Medicine, Turkey
    Acta Oncol 33:181-6. 1994
    ..It is concluded that monitoring with combinations of tumor markers at regular intervals increases the diagnostic efficiency...
  23. ncbi 240 hepatocellular carcinomas: ultrasound features, tumor size, cytologic and histologic patterns, serum alpha-fetoprotein and HBs Ag
    T Livraghi
    Servizio di Radiologia, Ospedale Civile, Vimercate, Italia
    Tumori 73:507-12. 1987
    ..Since the discovery of a small HCC is an incidental ultrasonographic finding in the context of severe liver disease, ultrasonographic monitoring of cirrhotic patients is the best available strategy to screen for small HCC...
  24. ncbi Primary mediastinal malignant germ cell tumour. Single institution experience in Chinese patients and correlation with specific alpha-fetoprotein bends
    A T Chan
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Acta Oncol 35:221-7. 1996
    ..In each case the change in NSGCT-specific AFP concentration in response to therapy closely paralleled that of total AFP. Estimation of NSGCT-specific AFP offers no apparent advantage in monitoring disease response or progression...
  25. ncbi Simultaneous determination of alpha-fetoprotein and carcinoembryonic antigen in human serum by time-resolved fluoroimmunoassay
    K Matsumoto
    Department of Chemistry, Waseda University, Shinjuku ku, Japan Science and Technology Corporation, Tokyo, 169 8555, Japan
    Anal Biochem 276:81-7. 1999
    ..A good correlation was obtained with the correlation coefficients of 0.990 for AFP and 0.973 for CEA...
  26. ncbi Clinical characteristics among patients with hepatocellular carcinoma according to the serum levels of alpha-fetoprotein and des-y-carboxy prothrombin
    Kazufumi Dohmen
    Clinical Research Center, National Nagasaki Medical Center, Nagasaki 856 8562, Japan
    Hepatogastroenterology 50:2072-8. 2003
    ..In the current study we investigated the different clinical variables in patients with hepatocellular carcinoma according to the serum levels of AFP and DCP...
  27. ncbi Maternal smoking: age distribution, levels of alpha-fetoprotein and human chorionic gonadotrophin, and effect on detection of Down syndrome pregnancies in second-trimester screening
    J A Crossley
    Institute of Medical Genetics, Yorkhill NHS Trust, Glasgow, G3 8SJ, UK
    Prenat Diagn 22:247-55. 2002
    ....
  28. ncbi [Melanoma antigen-3 expression in human hepatocellular carcinoma]
    S Cai
    Department of Surgery, People's Hospital, Beijing University, Beijing 100044, China
    Zhonghua Wai Ke Za Zhi 38:693-6. 2000
    ..The phenomena that some non-HCC adjacent tissues with heteromorphism can express MAGE-3 like their paired HCC tissues indicate that the expression of MAGE-3 may be an indicator in the early stage of carcinogenesis of liver tissues...
  29. doi Alterations of glycan branching and differential expression of sialic acid on alpha fetoprotein among hepatitis patients
    Gautam Mondal
    Department of School of Management and Science, West Bengal University of Technology, Salt Lake, Kolkata, 700064, India
    Glycoconj J 28:1-9. 2011
    ..Some of them, especially alpha fetoprotein (AFP), serve as useful biomarkers for HCC...
  30. ncbi Flavonoids inhibit estrogen binding to rat alpha-fetoprotein
    M E Baker
    Department of Medicine, University of California, San Diego, La Jolla 92093 0623, USA
    Proc Soc Exp Biol Med 217:317-21. 1998
    ..Finally, bioflavonoids should be useful tools for understanding the variety of estrogen actions initiated by different structural classes of estrogens...
  31. ncbi Circulating AFP mRNA as a Possible Indicator of Hematogenous Spread of HCC Cells: A Possible Association with HBV Infection
    Laila M Montaser
    The Departments of Clinical Pathology, Faculty of Medicine, Menofeya University
    J Egypt Natl Canc Inst 19:48-60. 2007
    Background: Circulating alpha fetoprotein messenger RNA (AFP mRNA) has been proposed as a marker of hepatocellular carcinoma (HCC) cells disseminated into the circulation...
  32. ncbi [The effect of a mixture of tegafur with uracil (UFT) on hepatocarcinogenesis in rats induced by 3'-methyl-4-dimethylaminoazobenzene. I. The influence on production of alpha-fetoprotein]
    H Hirai
    Tumor Laboratory, Tokyo
    Gan To Kagaku Ryoho 15:101-8. 1988
    ..These results show that if the administration of UFT was commenced at the same time with feeding 3'-MeDAB diet, the hepatocarcinogenesis and AFP production are strongly inhibited...
  33. ncbi Reference intervals for serum alpha-fetoprotein and carcinoembryonic antigen in Chinese Han ethnic males from the Fangchenggang Area Male Health and Examination Survey
    Xue Qin
    Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China
    Int J Biol Markers 26:65-71. 2011
    ..We calculated upper 95% reference limits for serum alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) according to the CLSI/NCCLS C28-A3 guideline...
  34. ncbi [Quantitation of alpha-fetoprotein messenger RNA in peripheral blood of nude mice and its relationship with tumor recurrence and metastasis after curative resection of hepatocellular carcinoma]
    Xiaofeng Wu
    Liver Cancer Institute, Fudan University, Shanghai 200032, China
    Zhonghua Gan Zang Bing Za Zhi 10:189-91. 2002
    ..To assess the level of alpha-fetoprotein (AFP) messenger RNA (mRNA) in peripheral blood of nude mice, and to study its relationship with tumor recurrence and metastasis after curative resection of hepatocellular carcinoma (HCC)...
  35. ncbi Lectin-reactive alpha-fetoprotein as a marker for testicular tumor activity
    Koji Kawai
    University of Tsukuba, Institute of Clinical Medicine, Department of Urology, Tsukuba, Ibaraki, Japan
    Int J Urol 12:284-9. 2005
    ..In the present study, we used the subfraction profile of LCA-binding AFP to diagnose and monitor testicular tumor activity...
  36. ncbi Clinicopathologic features of patients with intrahepatic cholangiocarcinoma who are seropositive for alpha-fetoprotein-L3 and those with combined hepatocellular and cholangiocarcinoma
    Hiroaki Okuda
    Institute of Gastroenterology, Tokyo Women s Medical University, Tokyo, Japan
    J Gastroenterol Hepatol 21:869-73. 2006
    ..Thus, the purpose of the present paper was to compare the features of ICC patients from the viewpoint of two different tumor markers, AFP-L3 and carbohydrate antigen (CA) 19-9...
  37. ncbi The intracellular mechanism of alpha-fetoprotein promoting the proliferation of NIH 3T3 cells
    Meng Sen Li
    Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, Beijing, China
    Cell Res 12:151-6. 2002
    ..The existence and properties of alpha-fetoprotein (AFP) receptor on the surface of NIH 3T3 cells and the effects of AFP on cellular signal transduction pathway were investigated...
  38. doi Development of high-performance magnetic chemiluminescence enzyme immunoassay for alpha-fetoprotein (AFP) in human serum
    Xu Wang
    The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, China
    Clin Chim Acta 393:90-4. 2008
    ....
  39. ncbi AFP-L3 in chronic liver diseases with persistent elevation of alpha-fetoprotein
    Hau Tsai Cheng
    Liver Research Unit, Chang Gung Memorial Hospital, Taoyuan, Taiwan, R O C
    J Chin Med Assoc 70:310-7. 2007
    ..However, persistent elevation of AFP is found in patients with chronic liver diseases. The value of AFP-L3, which is more specific than AFP, was examined in such patients...
  40. ncbi Sugar chains of human cord serum alpha-fetoprotein: characteristics of N-linked sugar chains of glycoproteins produced in human liver and hepatocellular carcinomas
    K Yamashita
    Department of Biochemistry, Sasaki Institute, Tokyo, Japan
    Cancer Res 53:2970-5. 1993
    ....
  41. ncbi Clinical evaluation of lentil lectin-reactive alpha-fetoprotein-L3 in histology-proven hepatocellular carcinoma
    V V Khien
    Department of Hepatology, Central Tran Hung Dao Hospital, Hanoi, Vietnam
    Int J Biol Markers 16:105-11. 2001
    ....
  42. ncbi Clinicopathologic features of patients with hepatocellular carcinoma seropositive for alpha-fetoprotein-L3 and seronegative for des-gamma-carboxy prothrombin in comparison with those seropositive for des-gamma-carboxy prothrombin alone
    Hiroaki Okuda
    Institute of Gastroenterology, Tokyo Women s Medical University, Japan
    J Gastroenterol Hepatol 17:772-8. 2002
    ..Thus, the present comparative study was performed...
  43. ncbi Quantitation of alpha-fetoprotein messenger RNA for early detection of recurrent hepatocellular carcinoma: a prospective pilot study
    H Schmilovitz-Weiss
    Tel Aviv University, Rabin Medical Center, Sackler School of Medicine, Gastroenterology Unit, Hasharon Golda Campus, Petah Tiqwa, Tel Aviv 49372, Israel
    Cancer Detect Prev 30:204-9. 2006
    ..The aim of this prospective pilot study was to assess the prognostic value of quantitative levels of AFP mRNA in patients undergoing ablative treatment for HCC...
  44. ncbi Alpha-fetoprotein and prognosis in acute liver failure
    Frank V Schiødt
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Liver Transpl 12:1776-81. 2006
    ..In this large prospective study, higher absolute values of AFP did not predict a favorable outcome, but a rising level of AFP over the first 3 hospital days frequently indicated survival...
  45. doi Diagnostic value of lectin reactive alpha-fetoprotein for neoinfantile hepatic tumors and malignant germ cell tumors: preliminary study
    Yoshiaki Kinoshita
    Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pediatr Hematol Oncol 30:447-50. 2008
    ..However, there are few reports dealing with various pediatric malignant tumors. In the current study, we analyzed the diagnostic value of AFP fractions for pediatric diseases, in particular, those occurring in the neoinfantile period...
  46. pmc Clinical evaluation of serum alpha-fetoprotein and circulating immune complexes as tumour markers of hepatocellular carcinoma
    J F Tsai
    Department of Internal Medicine, Kaohsiung Medical College, Taiwan, Republic of China
    Br J Cancer 72:442-6. 1995
    ..Determination of 3% PEG-CICs should be performed in cirrhotics negative for AFP to improve detection of HCC...
  47. pmc Structures of disease-specific serum alpha-fetoprotein isoforms
    P J Johnson
    Department of Clinical Oncology, Chinese University of Hong Kong, Shatin, Hong Kong
    Br J Cancer 83:1330-7. 2000
    ..Knowledge of the structure of the tumour-specific isoforms should form an important basis for clinically useful assays...
  48. ncbi Expression of chemoresistance-related proteins in alpha-fetoprotein-producing adenocarcinoma of the digestive organs
    Shingo Kamoshida
    Department of Pathology, Fujita Health University School of Medicine, Aichi 470 1192, Japan
    Oncol Rep 16:721-7. 2006
    ..S-1, a fluoropyrimidine containing a strong DPD inhibitor, may be effective for AFP-positive gastric cancers with poorly differentiated medullary growth pattern...
  49. ncbi Lens culinaris agglutinin-reactive alpha-fetoprotein and protein induced by vitamin K absence II are potential indicators of a poor prognosis: a histopathological study of surgically resected hepatocellular carcinoma
    Hisamitsu Miyaaki
    Department of Pathology and Research Center of Innovative Cancer Therapy of the 21st Century COE Program for Medical Science, Kurume University School of Medicine, Kurume, Japan
    J Gastroenterol 42:962-8. 2007
    ....
  50. doi Clinical implications of alpha-fetoprotein in chronic hepatitis C
    Wei Chen Tai
    Division of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Formos Med Assoc 108:210-8. 2009
    ..Alpha-fetoprotein (AFP) is important in the diagnosis of HCC, but elevated AFP levels have also been observed in CHC without HCC. We evaluated the clinical correlation between elevated AFP levels and CHC...
  51. doi Serum alpha-fetoprotein response as a surrogate for clinical outcome in patients receiving systemic therapy for advanced hepatocellular carcinoma
    Sadhna R Vora
    Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts 02114, USA
    Oncologist 14:717-25. 2009
    ..The role of serum alpha-fetoprotein (AFP) as a marker for treatment response in patients with hepatocellular carcinoma (HCC) receiving systemic therapy is poorly defined...
  52. ncbi Usefulness of the novel oncofetal antigen glypican-3 for diagnosis of hepatocellular carcinoma and melanoma
    Tetsuya Nakatsura
    Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    BioDrugs 19:71-7. 2005
    ..Thus, GPC3 is useful for diagnosis of HCC and melanoma and may also have a role in immunotherapy or tumor prevention. However, studies in humans are warranted...
  53. pmc Absence of gonadotropin-releasing hormone 1 and Kiss1 activation in alpha-fetoprotein knockout mice: prenatal estrogens defeminize the potential to show preovulatory luteinizing hormone surges
    David González-Martínez
    Research Group in Behavioral Neuroendocrinology, Center for Cellular and Molecular Neurobiology, University of Liege, Avenue de l Hopital, 4000 Sart Tilman Liège, Belgium
    Endocrinology 149:2333-40. 2008
    ....
  54. doi Review of the putative cell-surface receptors for alpha-fetoprotein: identification of a candidate receptor protein family
    Gerald J Mizejewski
    Wadsworth Center, Division of Translational Medicine, New York State Department of Health, Empire State Plaza, Albany, NY 12201, USA
    Tumour Biol 32:241-58. 2011
    ..Present data do not support the concept that the AFP receptor is a "universal" tumor receptor and/or biomarker...
  55. ncbi Highly enhanced fucosylation of alpha-fetoprotein in patients with germ cell tumor
    Y Aoyagi
    Department of Internal Medicine, Niigata University School of Medicine, Japan
    Cancer 72:615-8. 1993
    ..CONCLUSIONS. The current study indicates that the most characteristic feature of glycosylation of AFP in germ cell tumors is fucosylation rather than glucosaminylation...
  56. ncbi An intensive surveillance program detected a high incidence of hepatocellular carcinoma among hepatitis B virus carriers with abnormal alpha-fetoprotein levels or abdominal ultrasonography results
    Tony S K Mok
    Department of Clinical Oncology, Prince of Wales Hospital, School of Public Health, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    J Clin Oncol 23:8041-7. 2005
    ..To study the incidence and treatment outcomes of hepatocellular carcinoma (HCC) detected in an intensive surveillance program (ISP) of hepatitis B virus (HBV) carriers...
  57. ncbi Alpha-fetoprotein-specific transfer factors downregulate alpha-fetoprotein expression and specifically induce apoptosis in Bel7402 alpha-fetoprotein-positive hepatocarcinoma cells
    Hui Zhang
    School of Life Science, Shandong University, Jinan, China
    Hepatol Res 37:557-67. 2007
    ..Conclusion: AFP-TF induced Bel7402 cells apoptosis is mitochondrial-dependent and is mediated by the interaction of AFP-TF with intracellular AFP...
  58. ncbi alpha-fetoprotein causes apoptosis in tumor cells via a pathway independent of CD95, TNFR1 and TNFR2 through activation of caspase-3-like proteases
    E Dudich
    Institute of Engineering Immunology, Lyubuchany, Moscow Region, Russia
    Eur J Biochem 266:750-61. 1999
    ....
  59. ncbi Regulation of the alpha-fetoprotein gene by the isoforms of ATBF1 transcription factor in human hepatoma
    Toshiaki Ninomiya
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
    Hepatology 35:82-7. 2002
    ..Thus, the use of the ATBF1 variants as well as the silencer may provide a unique mechanism that contributes to the determination of AFP levels in human hepatoma cell lines...
  60. ncbi Clinicopathologic features of gastric cancers producing alpha-fetoprotein
    Koji Kono
    First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan
    Dig Surg 19:359-65; discussion 365. 2002
    ..The purpose of the present study was to clarify the clinicopathological features of AFP-producing gastric cancers, in particular characteristics of liver metastasis, and to evaluate treatment of these cancers...
  61. ncbi [Lectin-reactive alpha-fetoprotein in tyrosinaemia type I]
    U Baumann
    Universitätskinderklinik Essen, Abteilung für Allgemeine Kinderheilkunde mit Schwerpunkt Neuropädiatrie
    Klin Padiatr 217:142-6. 2005
    ..Lectin-reactive alpha-Fetoprotein is a recently described marker to distinguish hepatocellular carcinoma from benign liver disease in adult cirrhotic patients...
  62. ncbi Biological aggressiveness of alpha-fetoprotein (AFP)-positive gastric cancer
    Sumiya Ishigami
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890, Japan
    Hepatogastroenterology 53:338-41. 2006
    ..However, little information regarding the clinicopathological and biological behaviors of APGC is available due to the small size of reported series...
  63. ncbi A case of alpha-fetoprotein-producing adenocarcinoma of the endometrium with a hepatoid component as a potential source for alpha-fetoprotein in a postmenopausal woman
    K Takeuchi
    Department of Obstetrics and Gynecology, Hyogo Prefectural Tsukaguchi Hospital, 6 8 17 Minami tsukaguchicho, Amagasaki 661 0012, Japan
    Int J Gynecol Cancer 16:1442-5. 2006
    ....
  64. ncbi Lectin-reactive alpha-fetoprotein in patients with tyrosinemia type I and hepatocellular carcinoma
    Ulrich Baumann
    Children s Hospital, University of Essen, Essen, Germany
    J Pediatr Gastroenterol Nutr 43:77-82. 2006
    ..Lectin-affinity electrophoresis may have a role in discriminating benign liver disease from HCC in HT1. We suggest the further evaluation of L3-AFP in HT1...
  65. pmc The utility of Lens culinaris agglutinin-reactive alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: evaluation in a United States referral population
    Apinya Leerapun
    Miles and Shirley Fiterman Center for Digestive Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 5:394-402; quiz 267. 2007
    ..We evaluated the utility of AFP-L3% for diagnosis of HCC in a US referral population...
  66. ncbi [Correlation of perioperative alpha-fetoprotein expression in peripheral blood to recurrence of hepatocellular carcinoma]
    Ming Shi
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, PR China
    Ai Zheng 27:83-7. 2008
    ..This study was to explore the correlation of perioperative AFP expression in peripheral blood to recurrence of HCC...
  67. doi Clinical significance of elevated alpha-fetoprotein in Alaskan Native patients with chronic hepatitis C
    M G Bruce
    National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AL 99508, USA
    J Viral Hepat 15:179-87. 2008
    ..Serial AFP measurements appear to be useful in identifying persons with advanced fibrosis and help to determine who needs periodic screening with liver ultrasound to detect HCC...
  68. doi Alpha-fetoprotein as a tumor marker in hepatocellular carcinoma: investigations in south Indian subjects with hepatotropic virus and aflatoxin etiologies
    Kailapuri G Murugavel
    Infectious Diseases Laboratory, YRG Centre for AIDS Research and Education, VHS Hospital Campus, Taramani, Chennai 600 113, India
    Int J Infect Dis 12:e71-6. 2008
    ..We verified the usefulness of alpha-fetoprotein (AFP) as a tumor marker and analyzed the influence of viral etiology on AFP levels in HCC...
  69. doi Simultaneous determination of alpha-fetoprotein immune complexes and alpha-fetoprotein concentration in hepatocellular carcinoma using dual-label time-resolved immunofluorometric assays
    Shi Le Sheng
    Department of Nuclear Medicine, Renji Hospital, Shanghai Jiao Tong University Medical School, Shanghai, China
    J Clin Lab Anal 23:179-85. 2009
    ..The combined use of AFP-IgM and AFP increased the sensitivity of detection to 72.88% in patients with HCC. These data suggest that the use of a combination of two markers in clinical practice could increase the accuracy of HCC diagnosis...
  70. ncbi Specific uptake of alpha-fetoprotein and albumin by rat Morris 7777 hepatoma cells
    M A Alava
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain
    Tumour Biol 20:52-64. 1999
    ....
  71. pmc Risk of vaccine-associated paralytic poliomyelitis in Latin America, 1989-91
    J K Andrus
    Expanded Programme on Immunization, WHO Regional Office for South East Asia, New Delhi, India
    Bull World Health Organ 73:33-40. 1995
    ..These data suggest that to eradicate poliomyelitis globally, strategies that rely on mass immunization campaigns to supplement routine delivery services, as recommended by WHO, do not appear to alter significantly the risk of VAPP...
  72. pmc Epidemiology and clinical characteristics of acute flaccid paralysis associated with non-polio enterovirus isolation: the experience in the Americas
    V Dietz
    National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Bull World Health Organ 73:597-603. 1995
    ..It is therefore questionable whether characterization of NPEV isolates is essential for global eradication of poliomyelitis and consequently whether allocation of resources for that purpose can be justified...
  73. pmc Poliomyelitis in Oman: acute flaccid paralysis surveillance leading to early detection and rapid response to a type 3 outbreak
    S E Robertson
    Global Programme for Vaccines and Immunization, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 72:907-14. 1994
    ..Because AFP surveillance detected these cases rapidly, Oman was able to carry out outbreak control measures promptly and more than 350,000 extra doses of oral poliovirus vaccine were delivered to children under 6 years of age...
  74. pmc Screening of cases of acute flaccid paralysis for poliomyelitis eradication: ways to improve specificity
    J K Andrus
    EPI PAHO, Expanded Programme on Immunization, Pan American Health Organization, Washington, DC 20037
    Bull World Health Organ 70:591-6. 1992
    ....
  75. pmc Poliomyelitis surveillance in Shandong Province, China, 1990-92
    Y Chiba
    Department of EPI, Shandong Provincial Epidemic Prevention Station, Jinan, China
    Bull World Health Organ 72:915-20. 1994
    ..As the prevalence of wild poliovirus declines in China, reliable laboratory support needs to be established and adequately sensitive and specific AFP surveillance be developed if poliomyelitis is to be eradicated...
  76. ncbi Primary intracranial germ-cell tumors. A retrospective analysis with special reference to long-term results of treatment and the behavior of rare types of tumors
    N Sakai
    Department of Neurosurgery, Gifu University, School of Medicine, Japan
    Acta Oncol 27:43-50. 1988
    ..A review of the literature is included...
  77. ncbi [Ultrasonically guided radio-frequency ablation of liver tumors with a clustered electrode: a report of 100 cases]
    Q Ma
    Department of General Surgery, Tangdu Hospital, Forth Military Medical University, Xi'an 710038, China
    Zhonghua Wai Ke Za Zhi 38:272-4, 18. 2000
    ..AFP value decreased in 50% of patients, no operative death was noted, and the rate of operative complication was 23% after ablation. CONCLUSION: Ultrasound guided RF thermal ablation of hepatic tumors is safe, applicable and effective...
  78. ncbi Cisplatinum dose dependent response in germ cell cancer evaluated by tumour marker modelling
    J Carl
    Department of Experimental Clinical Oncology, Danish Cancer Society, Aalborg
    Acta Oncol 31:749-53. 1992
    ..Treatment response versus DDP dose appeared to be bi-phasic, but with no significant change in treatment efficiency within the given range of DDP doses...
  79. ncbi Serum levels of CA 125 in patients with gastrointestinal cancers
    Y T Omar
    Department of Radiotherapy, Kuwait Cancer Control Center, Shuwaikh
    Tumour Biol 10:316-23. 1989
    ....
  80. ncbi Isolation and properties of human alpha-fetoprotein from HepG2 cell cultures
    H F Deutsch
    Department of Biomolecular Chemistry, Laboratory Medicine and Medicine, University of Wisconsin, Madison, WI 53706, USA
    Tumour Biol 21:267-77. 2000
    ..Yields of 50-60% can be obtained from culture fluid containing 30-40 microg/ml. A minor fraction that appears to be a proteolytic product of the AFP is present in the final product...
  81. ncbi Screening for hepatocellular carcinoma in Alaska natives infected with chronic hepatitis B: a 16-year population-based study
    B J McMahon
    Departments of Internal Medicine and Surgery, Alaska Native Medical Center, Indian Health Service, Public Health Service, U S Department of Health and Human Services, Anchorage, Alaska, USA
    Hepatology 32:842-6. 2000
    ..024), respectively. Screening of HBsAg carriers with semiannual AFP was effective in detecting most HCC tumors at a resectable stage and significantly prolonged survival rates when compared with historical controls in this population...
  82. ncbi Relationship between antifreeze protein and freezing resistance in Pseudomonas putida GR12-2
    H Kawahara
    Department of Biotechnology, Kansai University, Suita, Osaka, Japan
    Curr Microbiol 43:365-70. 2001
    ..We conclude that accumulation of AFP is one component of the mechanism for freezing resistance in bacteria...
  83. ncbi Ultraviolet-sensitive syndrome cells are defective in transcription-coupled repair of cyclobutane pyrimidine dimers
    Graciela Spivak
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    DNA Repair (Amst) 1:629-43. 2002
    ....
  84. ncbi [Differential and common characteristics of patients with atypical facial pain and craniomandibular dysfunction]
    A Neff
    Klinik und Poliklinik für Mund Kiefer Gesichtschirurgie, Klinikum rechts der Isar, Technische Universitat Munchen, Munich
    Mund Kiefer Gesichtschir 7:227-34. 2003
    ..Whereas CMD patients respond to somatic approaches, somatization should be strictly avoided in AFP. The aim of this study was to establish prognostic criteria to identify an aggravated risk of a chronic course in CMD and AFP...
  85. ncbi ING1 represses transcription by direct DNA binding and through effects on p53
    Hiromi Kataoka
    Department of Biochemistry, University of Calgary, Alberta, Canada
    Cancer Res 63:5785-92. 2003
    ....
  86. ncbi Immunohistochemical expression of pi class glutathione S-transferase and alpha-fetoprotein in hepatocellular carcinoma and chronic liver disease
    Yasmin Anum Mohd Yusof
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia
    Anal Quant Cytol Histol 25:332-8. 2003
    ..To determine whether tumor marker pi glutathione transferase (GST-pi) is expressed in hepatocellular carcinoma (HCC) and other chronic liver diseases and to compare its expression with that of alpha-fetoprotein (AFP)...
  87. ncbi Identification of alpha-fetoprotein-derived peptides recognized by cytotoxic T lymphocytes in HLA-A24+ patients with hepatocellular carcinoma
    Eishiro Mizukoshi
    Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa 920 8641, Japan
    Int J Cancer 118:1194-204. 2006
    ..In conclusion, we identified five HLA-A*2402-restricted T-cell epitopes derived from AFP. The newly identified AFP epitopes could be a valuable component of HCC immunotherapy and for analyzing host immune responses to HCC...
  88. ncbi Conditionally replicative adenovirus vector carrying TRAIL gene for enhanced oncolysis of human hepatocellular carcinoma
    Xun Ye
    Department of Pharmacology, College of Basic Medical Sciences, Shanghai Jiao Tong University, Shanghai 200025, PR China
    Int J Mol Med 16:1179-84. 2005
    ..Considering that oncolytic viruses destroy tumor cells expressing low levels of the tumor marker is a clinical concern, TRAIL might be a useful tool to improve the efficacy of these vectors...
  89. ncbi New perspectives and strategy research biomarkers for hepatocellular carcinoma
    Raphael Saffroy
    Service de Biochimie, Biologie Moléculaire et Toxicologie, Hôpital Universitaire Paul Brousse, Universite Paris Sud, UMR S602, Villejuif, INSERM, Villejuif, France
    Clin Chem Lab Med 45:1169-79. 2007
    ..This review summarizes the current state of biomarkers for screening, diagnosis and follow-up of HCC, and highlights new perspectives in the field...
  90. ncbi Genetic alterations of the ATBF1 gene in gastric cancer
    Yong Gu Cho
    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Clin Cancer Res 13:4355-9. 2007
    ....
  91. doi Hepatoid esophageal carcinoma: a rare cause of elevated alpha fetoprotein
    Muslim Atiq
    Division of Gastroenterology, Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    J Gastrointest Cancer 39:58-60. 2008
    ..We present an interesting case of AFP-producing esophageal tumor, describing its clinical presentation, endoscopic manifestation, as well as histological features...
  92. pmc Proteomic expression signature distinguishes cancerous and nonmalignant tissues in hepatocellular carcinoma
    Nikki P Lee
    Department of Surgery, Center for Cancer Research, and Department of Chemistry, The University of Hong Kong, Pokfulam, Hong Kong
    J Proteome Res 8:1293-303. 2009
    ..The described model using biomarker signatures could accurately distinguish HCC from nonmalignant tissues, which may also provide hints on how normal hepatocytes are transformed to malignant state during tumor progression...
  93. doi An electrochemical immunoassay for protein based on bio bar code method
    Caifeng Ding
    Key Laboratory of Eco Chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
    Biosens Bioelectron 24:2434-40. 2009
    ..It would be valuable for clinical immunoassay due to the high sensitivity and selectivity...
  94. ncbi Markedly-elevated serum CA125 in a woman with pulmonary tuberculosis
    S Sulaiman
    Division of Obstetrics and Gynaecology, KK Women s and Children s Hospital, Singapore
    Singapore Med J 50:e39-40. 2009
    ..A non-gynaecological diagnosis like pulmonary tuberculosis must always be considered as one of a differential diagnosis in a woman presenting with a markedly-raised CA125...
  95. pmc Derivation and characterization of hepatic progenitor cells from human embryonic stem cells
    Dongxin Zhao
    Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing, China
    PLoS ONE 4:e6468. 2009
    ..These hES cell-derived hepatic progenitor cells could be effectively used as an in vitro model for studying the mechanisms of hepatic stem/progenitor cell origin, self-renewal and differentiation...
  96. doi Primary carcinoid tumors of the testis: a clinicopathologic study of 29 cases
    Wenle P Wang
    Departments of Pathology, VA Maryland Health Care System, USA
    Am J Surg Pathol 34:519-24. 2010
    ..However, lesions with the morphology of atypical carcinoid can occasionally exhibit metastatic spread...
  97. doi Epistatic effect between ACACA and FABP2 gene on abdominal fat traits in broilers
    Guo Hu
    College of Animal Science and Technology, Northeast Agricultural University, Harbin, China
    J Genet Genomics 37:505-12. 2010
    ..Our results could be helpful in further understanding the genetic interaction between candidate genes contributing to phenotypic variation of abdominal fat content in broilers...
  98. doi Predictive value of tumor markers for hepatocarcinogenesis in patients with hepatitis C virus
    Takashi Kumada
    Department of Gastroenterology, Ogaki Municipal Hospital, 4 86, Minaminokawa cho, Ogaki, Gifu 503 8052, Japan
    J Gastroenterol 46:536-44. 2011
    ....
  99. doi Clinical utility of highly sensitive Lens culinaris agglutinin-reactive alpha-fetoprotein in hepatocellular carcinoma patients with alpha-fetoprotein <20 ng/mL
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Cancer Sci 102:1025-31. 2011
    ..001). In patients with AFP <20 ng/mL, measurements of AFP-L3% by the highly sensitive method before treatment were more useful for diagnosis and prognosis of HCC than by the conventional method...
  100. pmc Identification of serum biomarkers of hepatocarcinoma through liquid chromatography/mass spectrometry-based metabonomic method
    Feng Chen
    State Key Laboratory of Infectious Disease Diagnosis and Treatment, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Anal Bioanal Chem 401:1899-904. 2011
    ..Overall, these results suggested that LC/MS-based metabonomic study is a potent and promising strategy for identifying novel biomarkers of HCC...
  101. doi An autopsy case of clear cell adenocarcinoma of the urinary bladder
    Tadashi Terada
    Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan
    Appl Immunohistochem Mol Morphol 21:371-5. 2013
    ..Metastases showed the same immunohistochemical findings...

Research Grants64

  1. AFP-Based Immunotherapy for Hepatocellular Carcinoma
    Antoni Ribas; Fiscal Year: 2006
    ..In previous work we have shown that both the murine and human T cell repertoires can recognize alpha fetoprotein (AFP)-derived peptide epitopes in the context of MHC...
  2. Radoslav Goldman; Fiscal Year: 2016
    ..in serum and have the potential to improve detection of HCC compared to the serologic gold standard, alpha fetoprotein (AFP)...
  3. Fate-mapping temporally marked precursor populations to hepatocellular carcinoma
    Hyam L Leffert; Fiscal Year: 2013
    ..It is expected that knowledge of the basic cellular etiologies of hepatocarcinogenesis will lead to targeting strategies for treatment of HCC. This research addresses missions of the NCI, NIDDKD and NIAID. ..
  4. Development of a Urine Test for the Early Detection of Liver Cancer
    Wei Song; Fiscal Year: 2012
    ..The goal of this phase I project is to explore the ability of a urine DNA test to detect early stages o liver cancer by analyzing liver cancer-associated genetic and epigenetic modifications. ..
  5. Pregnancy Hormonal Profile/Biomarker Breast Cancer Risk
    Alan Arslan; Fiscal Year: 2004
    ..Moreover, specific hormone(s) or its analogues responsible for protective effect of pregnancy against breast cancer could be used for development of novel strategies for primary chemoprevention of breast cancer. ..
  6. Brett T Spear; Fiscal Year: 2015
    ..The long-term goal of these studies is to understand the basic mechanisms that govern the zonal regulation of many liver genes which will lead to better treatment of liver disease in humans. ..
  7. In Vitro Reconstitution of Alpha Fetroprotein Regulation
    Michelle Barton; Fiscal Year: 2007
    ..To test this hypothesis, we will assemble AFP gene templates into developmentally repressed, solid-phase nuclei and analyze chromatin structure and transcription function before and after DNA replication. ..
  8. REGULATION OF ALPHA-FETOPROTEIN GENE EXPRESSION
    Shirley Tilghman; Fiscal Year: 1993
    ..m) ..
  9. LARGE DELETION ADENOVIRAL VECTORS FOR CYSTIC FIBROSIS
    WANDA O NEAL; Fiscal Year: 1999
    ..After vector propagation, the vectors will be tested in the appropriate in vivo and in vitro models to determine their potential value in humans. ..
  10. Genetic Immunotherapy for Hepatocellular Cancer
    James Economou; Fiscal Year: 2004
    ..Both the murine and human T cell repertoires can recognize alpha fetoprotein (AFP), an oncofetal protein produced by a majority of HCC...
  11. Synthetic Peptides from AFP Prevent Breast Cancer
    Thomas Andersen; Fiscal Year: 2006
    ..AFPep has the potential to be used in combination with tamoxifen or as a stand-alone preventive agent. Its development and introduction to the clinic could prevent as many as 50,000 cases of breast cancer every year. ..
  12. IDENTIFYING AFR2--GENE REGULATOR IN LIVER PATHOLOGY
    MIRIAM FEUERMAN; Fiscal Year: 1999
    ..Identifying and isolating a clone of the Afr2 gene will provide a tool to study the relationships between developmental growth, controlled growth, and uncontrolled tumorigenic growth in the liver. ..
  13. RECONSTITUTION OF GENE REGULATION IN LIVER REGENERATION
    Michelle Barton; Fiscal Year: 2003
    ..The long-term goal of these studies is to learn how regenerative organs, such as the liver are capable of redirecting their genetic programs in response to traumatic injury. ..
  14. PREVENTION OF LIVER CANCER--EAST ASIANS IN PHILADELPHIA
    W London; Fiscal Year: 1991
    ..At high risk are chronic carriers of hepatitis B virus (HBV), and rises in the serum alpha fetoprotein (AFP) levels indicate early PHC's...
  15. Gravidomimetic Prevention of Breast Cancer
    Thomas Andersen; Fiscal Year: 2002
    ..Moreover, it blocks tamoxifen-stimulated uterine growth. Therefore it has potential to be used alone as well as in combination for the chemoprevention of breast cancer. ..
  16. DEVELOPMENTAL & NEOPLASTIC GENE EXPRESSION IN THE LIVER
    Joseph Locker; Fiscal Year: 1993
    ..Other experiments will study how oncogenes interact with the transcription controls, and characterize oncogenes that bypass the AFP repressor...
  17. IMMUNOCHEMICAL STUDIES OF GASTROINTESTINAL CANCER
    Elliot Alpert; Fiscal Year: 1980
    ....
  18. Afri 1: Gene Cloning and its Role in Liver Regulation
    Brett Spear; Fiscal Year: 2006
    ..We can then understand how Afr1 regulates AFP and we are likely to learn more about the transcription/post/transcriptional connections as well as how this may be developmentally regulated to control gene expression. ..
  19. REGULATION OF EUKAROYTIC GENE EXPRESSION
    LUCIA ROTHMAN DENES; Fiscal Year: 1991
    ..The knowledge acquired will allow us to understand the processes that lead to cell differentiation and to dedifferentiation during tumorigenesis...
  20. ENHANCERS AND LIVER-SPECIFIC TRANSCRIPTION
    Brett Spear; Fiscal Year: 2001
    ..In addition, the information derived from these studies may improve strategies to express foreign genes within the liver, a goal of many gene therapy trials. ..
  21. ALPHA-FETOPROTEIN IN FETAL & CANCER LIVERS
    Jen Fu Chiu; Fiscal Year: 1993
    ....
  22. LONG DISTANCE CONTROL OF LIVER GENE EXPRESSION
    Joseph Locker; Fiscal Year: 2007
    ..The system will be used to define the relationships of individual enhancers and promoters, a set of new regulatory elements identified in sequence analysis, and specific transcriptional mechanisms. ..
  23. GLYCOSYLATION STATUS ASSAYS FOR DIAGNOSTIC TUMOR MARKERS
    David Smith; Fiscal Year: 1992
    ....
  24. Anand S Mehta; Fiscal Year: 2016
    ..The ability of these markers to distinguish HCC from cirrhosis as compared to AFP and other potential biomarkers of HCC will be determined. ..
  25. A novel diagnostic biomarker for hepatocellular carcinoma and cholangiocarcinoma
    Xuanyong Lu; Fiscal Year: 2012
    ....
  26. HCC diagnostics defined by fucosylated serum biomarkers
    Anand Mehta; Fiscal Year: 2009
    ..Our ultimate goal is to develop an early detection diagnostics that can be used as a routine clinical screen in patients with high risk for developing liver cancer. ..
  27. Surbhi Jain; Fiscal Year: 2015
    ....
  28. Xiaobin Wang; Fiscal Year: 2014
    ....
  29. Xin Wen; Fiscal Year: 2016
    ..The proposed research will provide insights into the molecular mechanism of AFP and AFP enhancers and resolve conflicting reports regarding the mechanism of action of AFPs. ..
  30. Structure-Function Studies of Antifreeze Proteins
    FRANK SONNICHSEN; Fiscal Year: 2005
    ..3) the AFP-water interactions will be characterized by NMR spectroscopy, and methods will be developed to study the protein in supercooled solution and upon binding to ice. ..
  31. Kaumudi J Joshipura; Fiscal Year: 2016
    ..by applicant): Obesity and hyperglycemia in pregnancy impact fetal growth through over-nutrition and may stress the feta pancreas...
  32. AFP-BASED PRIME-BOOST IMMUNOTHERAPY OF HCC
    LISA BUTTERFIELD; Fiscal Year: 2006
    ..Previously, we made the novel observation that alpha fetoprotein (AFP) can be recognized by human and murine immune systems...
  33. Jerome F Strauss; Fiscal Year: 2016
    ..The goal of this Specific Aim is to test candidate genetic variants from regions identified in the feta (neonatal) AM and exome sequencing to determine if they are in association and linkage with PPROM, conferring risk ..
  34. Identifying mechanisms of liver stem cell proliferation and differentiation
    CARL BARTH ROUNTREE; Fiscal Year: 2010
    ..This proposal identifies the three key elements to oval cell based therapy: 1) reliable identification, 2) mechanisms of proliferation, and 3) key factors in differentiation. ..
  35. Michale S Fee; Fiscal Year: 2014
    ..Disorders of BG circuitry lead to the impairments of serial processing and sequential behaviors observed in Parkinson's disease, schizophrenia, obsessive-compulsive disorder, Huntington's and the tardive syndromes. ..
  36. Achyuta Adhvaryu; Fiscal Year: 2016
    ..I will accomplish the last aim through two studies. In the first, I will study the effects of a large feta iodine supplementation program in Tanzania using an existing, nationally representative dataset...
  37. Study of a novel picornavirus genus associated with Acute Flaccid Paralysis
    Amit Kapoor; Fiscal Year: 2012
    ..Our long-term goal is to define the pathogenic potential of HCoSV and to prevent new infections. ..
  38. LISA HELENE BUTTERFIELD; Fiscal Year: 2014
    ..Rational design of vaccines, based on this new information should allow for more rational design of the immune activation to be achieved by newer vaccines. ..
  39. ORGANOPHOSPHATE PESTICIDES AND HUMAN REPRODUCTIVE HEALTH
    Xiping Xu; Fiscal Year: 2003
    ..S.; and (9) the population possesses unique characteristics for examining the proposed hypothesis, i.e., a stable workforce, a non-smoking group and excellent compliance rates. ..
  40. Function of basal ganglia-cortical circuits in vocal learning in early life
    Satoshi Kojima; Fiscal Year: 2013
    ....
  41. Michael S Brainard; Fiscal Year: 2015
    ..abstract_text> ..
  42. Tushar Patel; Fiscal Year: 2014
    ....
  43. Automated Function Prediction (AFP 2011)
    Predrag Radivojac; Fiscal Year: 2011
    ..The meeting will consist of a series of talks and discussion sections dedicated to protein function research and will also provide a large-scale assessment of computational methods for automated functional annotation of proteins. ..
  44. Behavioral and Neural Analysis of vocal Plasticity
    Michael S Brainard; Fiscal Year: 2013
    ..abstract_text> ..
  45. DDT, Endocrine Disruption and Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2003
    ....
  46. NEUROBIOLOGY OF SENSORY ACQUISITION
    Patrice Adret; Fiscal Year: 2001
    ..These experiments may give initial insight into the mechanisms that lead to the formation, storage and retrieval of auditory memories in songbirds. ..
  47. Hex - a Homeobox Gene Essential for Liver Development
    CLIFFORD BOGUE; Fiscal Year: 2007
    ..Additionally, this research will shed important insight into the pathogenesis of diseases of the biliary tract, including biliary atresia and polycystic liver disease. ..
  48. Polymer-Based Yersinia Pestis Point-of-Case Diagnostics
    Jean Clarke; Fiscal Year: 2004
    ..This basic approach will be immediately applicable to biodefense but will allow further extension into biomedical research, medical diagnostics, and other pathogen detection and identification applications. ..
  49. XENOBIOTIC METABOLISM IN FETAL HEMATOPOIETIC CELLS
    Kathleen Shiverick; Fiscal Year: 1992
    ..rats treated with fetotoxic doses of beta NF, MC, TCDD with the following objectives: 1) Determined whether feta blood has altered numbers of red cells, white cells and platelets, or hemoglobin content; Investigate whether ..
  50. REGULATION OF MACROPHAGE INTERLEUKIN-1 BETA PRODUCTION
    MARK WEWERS; Fiscal Year: 2006
    ..This protein complex induces the activation of ICE and places it and IL-1 feta into a composite of release-regulating proteins that orchestrate mature cytokine export...
  51. Functions of ADARI RNA Editase in Erythropoiesis
    Kazuko Nishikura; Fiscal Year: 2005
    ..Our research may reveal critical information leading to new strategies for therapeutic intervention for certain human dyserythropoietic disorders. ..
  52. Live Cell Imaging with Fluorescent Polymer Bioconjugates
    JOONGHO MOON; Fiscal Year: 2005
    ..Successful development of CPB will provide novel platforms for understanding signaling pathways, which will strongly impact the understanding of complex cellular process. ..
  53. ANALYSIS OF 3 CARDIAC NA,K- TPASE A-SUBUNIT ISOFORMS
    Nelson Ruiz Opazo; Fiscal Year: 1991
    ..Of interest is their unique developmental expression in the heart. The alpha 1 isoform is constitutive; alpha 2 is feta/neonatal predominant; and alpha 3 is adult predominant...
  54. Contribution of Estradiol to Female Neural Development
    Michael Baum; Fiscal Year: 2009
    ..Affirmation of a perinatal role for estradiol in brain sexual differentiation in female mice would raise the question of whether estradiol plays a similar role in female-typical psychosexual differentiation in women. ..
  55. MECHANISMS OF FETAL GROWTH RETARDATION
    Kenneth Clark; Fiscal Year: 1992
    ..01) between uteroplacental blood flow and ponderal index, feta body weight, fetal heart and thymus weights and placental weight...
  56. FETAL NUTRIENT THERAPY: EFFECTS ON GROWTH RETARDATION
    Valerie Charlton; Fiscal Year: 1992
    ..glucose alone, amino acids alone, or the total calories infused; 5) effects growth through changes in placental or feta secretion of growth promoting hormones; and 6) can be given through other routes...
  57. Fetal Swallowing: Central Dipsogenic Mechanisms
    Michael Ross; Fiscal Year: 2007
    ..Ovine feta osmotic-dipsogenic systems become functional ("switch-on") acutely during the last third of gestation, though the ..
  58. PREMALIGNANT AND MALIGNANT HEPATOCYTE AFP GLYCOSYLATION
    PHILIP KELLEHER; Fiscal Year: 1992
    ..Peptide:N-glycosidase-released AFP oligosaccharides will be analyzed by HPLC and their monosaccharide composition determined by GLC. Half-lives of AFP glycoforms present in postpartum maternal serum will be determined...
  59. PRIMATE ENDOCRINE REGULATION IN THE PERINATAL PERIOD
    Robert Jaffe; Fiscal Year: 2003
    ..g. feta lung maturation, deposition of glycogen in the fetal liver, and induction of enzymes in the fetal brain, thyroid, ..
  60. Identification of serum glycosylation markers of HCC
    Anand Mehta; Fiscal Year: 2002
    ..Obviously the technology would be applicable to any cancer system where oligosaccharide changes are associated with development to neoplasia. ..
  61. Identification of serum glycosylation markers of HCC
    Anand Mehta; Fiscal Year: 2004
    ..Obviously the technology would be applicable to any cancer system where oligosaccharide changes are associated with development to neoplasia. ..
  62. DIADENOSINE TETRAPHOSPHATE--A ROLE IN OXIDATIVE STRESS
    LARRY BARNES; Fiscal Year: 1990
    ..Thus, elucidation of Ap4A as a regulatory nucleotide for oxidative stress would be relevant to physiologic and pathophysiologic processes...
  63. AFP GENE EXPRESSION AND CARCINOGENESIS
    Stewart Sell; Fiscal Year: 1990
    ..This work will ultimately lead to a complete understanding of how gene expression is altered during carcinogenesis and in the neoplastic state...
  64. Control of cell polarity in the C. elegans zygote
    Geraldine Seydoux; Fiscal Year: 2005
    ..We anticipate that our studies will provide significant insights into these processes by taking advantage of the experimental attributes of a simple model system...