ALK

Summary

Gene Symbol: ALK
Description: ALK receptor tyrosine kinase
Alias: CD246, NBLST3, ALK tyrosine kinase receptor, CD246 antigen, anaplastic lymphoma receptor tyrosine kinase, mutant anaplastic lymphoma kinase
Species: human

Top Publications

  1. ncbi Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
    Klarisa Rikova
    Cell Signaling Technology, 3 Trask Lane, Danvers, MA 01923, USA
    Cell 131:1190-203. 2007
  2. doi The emerging pathogenic and therapeutic importance of the anaplastic lymphoma kinase gene
    Fergal C Kelleher
    Department of Medical Oncology, Adelaide and Meath Hospital, Dublin, Ireland
    Eur J Cancer 46:2357-68. 2010
  3. pmc Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis
    Alice T Shaw
    Massachusetts General Hospital Cancer Center, Boston, MA, USA
    Lancet Oncol 12:1004-12. 2011
  4. doi MiR-29a down-regulation in ALK-positive anaplastic large cell lymphomas contributes to apoptosis blockade through MCL-1 overexpression
    Cecile Desjobert
    Centre de Recherches en Cancérologie de Toulouse, INSERM UMR1037, Universite Paul Sabatier, Toulouse Cedex 3, France
    Blood 117:6627-37. 2011
  5. pmc ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: an analysis of 1,683 patients with non-small cell lung cancer
    Justin F Gainor
    Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Cancer Res 19:4273-81. 2013
  6. ncbi Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin
    Christel Moog-Lutz
    INSERM, Unité 706 Université Pierre et Marie Curie, Paris F 75005, France
    J Biol Chem 280:26039-48. 2005
  7. doi EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas
    Kazuya Shinmura
    1st Department of Pathology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi Ward, Hamamatsu 431 3192, Japan
    Lung Cancer 61:163-9. 2008
  8. ncbi Characterization of some molecular mechanisms governing autoactivation of the catalytic domain of the anaplastic lymphoma kinase
    Carmen J Tartari
    Department of Clinical and Prevention Medicine, University of Milano Bicocca, Via Cadore 48, Monza 20052, Italy
    J Biol Chem 283:3743-50. 2008
  9. doi Clinicopathologic implication of ALK rearrangement in surgically resected lung cancer: a proposal of diagnostic algorithm for ALK-rearranged adenocarcinoma
    Jin Ho Paik
    Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea
    Lung Cancer 76:403-9. 2012
  10. doi ALK amplification and protein expression predict inferior prognosis in neuroblastomas
    Miao Wang
    Department of Pathology, Basic Medical College, Capital Medical University, Beijing, China
    Exp Mol Pathol 95:124-30. 2013

Research Grants

  1. NATHANAEL SCHIANDER GRAY; Fiscal Year: 2015
  2. Hesham M Amin; Fiscal Year: 2015
  3. The Role of NPM-ALK Signaling in Tumor Cell Metabolism
    SCOTT RP MCDONNELL; Fiscal Year: 2012
  4. Novel role of STAT3 in NPM/ALK-induced oncogenesis
    Mariusz A Wasik; Fiscal Year: 2013
  5. Proteomic biomarkers of ALK+ lymphoma
    Megan S Lim; Fiscal Year: 2013
  6. Jie Wu; Fiscal Year: 2014
  7. Youli Zu; Fiscal Year: 2014
  8. Arul M Chinnaiyan; Fiscal Year: 2015
  9. Marc Ladanyi; Fiscal Year: 2016
  10. Alice T Shaw; Fiscal Year: 2016

Detail Information

Publications240 found, 100 shown here

  1. ncbi Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
    Klarisa Rikova
    Cell Signaling Technology, 3 Trask Lane, Danvers, MA 01923, USA
    Cell 131:1190-203. 2007
    ..signaling are generated and analyzed to identify known oncogenic kinases such as EGFR and c-Met as well as novel ALK and ROS fusion proteins...
  2. doi The emerging pathogenic and therapeutic importance of the anaplastic lymphoma kinase gene
    Fergal C Kelleher
    Department of Medical Oncology, Adelaide and Meath Hospital, Dublin, Ireland
    Eur J Cancer 46:2357-68. 2010
    The anaplastic lymphoma kinase gene (ALK) is a gene on chromosome 2p23 that has expression restricted to the brain, testis and small intestine but is not expressed in normal lymphoid tissue...
  3. pmc Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis
    Alice T Shaw
    Massachusetts General Hospital Cancer Center, Boston, MA, USA
    Lancet Oncol 12:1004-12. 2011
    b>ALK gene rearrangement defines a new molecular subtype of non-small-cell lung cancer (NSCLC)...
  4. doi MiR-29a down-regulation in ALK-positive anaplastic large cell lymphomas contributes to apoptosis blockade through MCL-1 overexpression
    Cecile Desjobert
    Centre de Recherches en Cancérologie de Toulouse, INSERM UMR1037, Universite Paul Sabatier, Toulouse Cedex 3, France
    Blood 117:6627-37. 2011
    ..has been described in solid cancers and leukemias, little evidence of miRNA deregulation has been reported in ALK-positive (ALK(+)) anaplastic large cell lymphomas (ALCL)...
  5. pmc ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: an analysis of 1,683 patients with non-small cell lung cancer
    Justin F Gainor
    Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Cancer Res 19:4273-81. 2013
    Anaplastic lymphoma kinase (ALK) gene rearrangements define a distinct molecular subset of non-small cell lung cancer (NSCLC)...
  6. ncbi Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin
    Christel Moog-Lutz
    INSERM, Unité 706 Université Pierre et Marie Curie, Paris F 75005, France
    J Biol Chem 280:26039-48. 2005
    Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that is transiently expressed in specific regions of the central and peripheral nervous systems, suggesting a role in its normal development and function...
  7. doi EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas
    Kazuya Shinmura
    1st Department of Pathology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi Ward, Hamamatsu 431 3192, Japan
    Lung Cancer 61:163-9. 2008
    EML4-ALK gene fusions have recently been discovered in a subset of human lung carcinomas, and fusions of the ALK tyrosine kinase gene with the NPM, TPM3, CLTC, ATIC, and TFG genes have been found in hematological malignancies...
  8. ncbi Characterization of some molecular mechanisms governing autoactivation of the catalytic domain of the anaplastic lymphoma kinase
    Carmen J Tartari
    Department of Clinical and Prevention Medicine, University of Milano Bicocca, Via Cadore 48, Monza 20052, Italy
    J Biol Chem 283:3743-50. 2008
    NPM/ALK is an oncogenic fusion protein expressed in approximately 50% of anaplastic large cell lymphoma cases...
  9. doi Clinicopathologic implication of ALK rearrangement in surgically resected lung cancer: a proposal of diagnostic algorithm for ALK-rearranged adenocarcinoma
    Jin Ho Paik
    Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea
    Lung Cancer 76:403-9. 2012
    To characterize the clinicopathologic features of ALK-rearranged lung cancer, and suggest a molecular test protocol for lung adenocarcinoma in the small biopsy specimen.
  10. doi ALK amplification and protein expression predict inferior prognosis in neuroblastomas
    Miao Wang
    Department of Pathology, Basic Medical College, Capital Medical University, Beijing, China
    Exp Mol Pathol 95:124-30. 2013
    b>ALK gene has been identified as a major neuroblastoma (NBL) predisposition gene. But ALK gene copy number and protein expression in ganglioneuroblastoma (GNBL) and ganglioneuroma (GN) are poorly described in the literature...
  11. pmc ALK gene amplification is associated with poor prognosis in colorectal carcinoma
    P Bavi
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia
    Br J Cancer 109:2735-43. 2013
    Recently, the anaplastic lymphoma kinase (ALK) has been found to be altered in several solid and haematological tumours. ALK gene copy number changes and mutations in colorectal cancers (CRCs) are not well characterised...
  12. ncbi TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations
    L Hernandez
    Laboratory of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Blood 94:3265-8. 1999
    Anaplastic large cell lymphoma (ALCL) is associated with the t(2;5)(p23;q35), which generates the NPM-ALK fusion gene encoding an 80-kD protein. Several studies have suggested that genes other than NPM may be fused to the ALK gene...
  13. doi ALK gene translocations and amplifications in brain metastases of non-small cell lung cancer
    Matthias Preusser
    Department of Medicine I, Medical University of Vienna, Austria
    Lung Cancer 80:278-83. 2013
    Increased incidence of brain metastases (BM) in non-small cell lung cancer (NSCLC) with ALK translocations was postulated, however, ALK gene aberrations in NSCLC-BM have not been investigated so far.
  14. doi Simultaneous targeting of insulin-like growth factor-1 receptor and anaplastic lymphoma kinase in embryonal and alveolar rhabdomyosarcoma: a rational choice
    J Carlijn van Gaal
    Department of Medical Oncology, Radboud University Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur J Cancer 49:3462-70. 2013
    ..The aim of this study is to investigate anaplastic lymphoma kinase (ALK) and insulin-like growth factor-1 receptor (IGF-1R) as potential therapeutic targets in RMS.
  15. pmc Anaplastic lymphoma kinase is expressed in different subtypes of human breast cancer
    Pablo Perez-Pinera
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Biochem Biophys Res Commun 358:399-403. 2007
    ..protein tyrosine phosphatase (RPTP)beta/zeta, and, recently, PTN was found to activate anaplastic lymphoma kinase (ALK) through the PTN/RPTPbeta/zeta signaling pathway in PTN-stimulated cells, not through a direct interaction of PTN ..
  16. ncbi Expression and functional analysis of the anaplastic lymphoma kinase (ALK) gene in tumor cell lines
    Willy G Dirks
    Department of Human and Animal Cell Lines, DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Int J Cancer 100:49-56. 2002
    The initial identification of the ALK gene, expressed as C-terminal part of the transforming fusion protein NPM-ALK in the t(2;5)(p23;q35) lymphoma-associated chromosomal translocation, revealed a novel receptor tyrosine kinase (RTK)...
  17. ncbi ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation
    Joffrey Degoutin
    INSERM, U706 UPMC, Institut du Fer a Moulin, 17 Rue du Fer a Moulin, 4 place Jussieu, F 75005 Paris, France
    FEBS Lett 581:727-34. 2007
    Activation of the neuronal receptor tyrosine kinase ALK (anaplastic lymphoma kinase) promoted the neuron-like differentiation of PC12 cells through specific activation of the ERK MAP-kinase pathway...
  18. pmc Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity
    R Y Bai
    Laboratory of Leukemogenesis, Department of Internal Medicine III, Technical University of Munich, Munich, Germany
    Mol Cell Biol 18:6951-61. 1998
    ..a hybrid protein comprised of the nucleolar phosphoprotein nucleophosmin (NPM) and the anaplastic lymphoma kinase (ALK)...
  19. ncbi Unique substrate specificity of anaplastic lymphoma kinase (ALK): development of phosphoacceptor peptides for the assay of ALK activity
    Arianna Donella-Deana
    Department of Biochemistry, University of Padova, Viale G Colombo 3, 35121 Padova, Italy
    Biochemistry 44:8533-42. 2005
    The anaplastic lymphoma kinase (ALK), whose constitutively active fusion proteins are responsible for 5-10% of non-Hodgkin's lymphomas, shares with the other members of the insulin receptor kinase (IRK) subfamily an activation loop (A-..
  20. ncbi Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas
    A Colomba
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    Oncogene 27:2728-36. 2008
    The majority of anaplastic large cell lymphomas (ALCLs) express the nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) fusion protein, which is oncogenic due to its constitutive tyrosine kinase activity...
  21. pmc Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)
    J Fujimoto
    Department of Oncology, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 93:4181-6. 1996
    ..of this cDNA turned out to be virtually identical to that of the fusion cDNA for NPM-anaplastic lymphoma kinase (ALK) previously cloned from the transcript of the gene at the breakpoint of the same translocation...
  22. ncbi ALK-positive lymphoma: a single disease with a broad spectrum of morphology
    D Benharroch
    Department of Pathology and CIGH CNRS, CHU Purpan, Toulouse, France
    Blood 91:2076-84. 1998
    ..translocation, associated with anaplastic large-cell lymphoma (ALCL), results in the expression of a chimeric NPM-ALK protein that can be detected by the ALK1 monoclonal antibody...
  23. ncbi Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor
    Jan Cools
    Center for Human Genetics, Flanders Interuniversity Institute for Biotechnology VIB, University of Leuven, Campus Gasthuisberg O and N 06, Herestraat 49, B 3000 Leuven, Belgium
    Genes Chromosomes Cancer 34:354-62. 2002
    b>ALK-positive anaplastic large-cell lymphoma (ALCL) has been recognized as a distinct type of lymphoma in the heterogeneous group of T/Null-ALCL...
  24. ncbi STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19104 4283, USA
    Nat Med 13:1341-8. 2007
    ..by DNA methylation of the STAT5A gene promoter region in cells expressing the oncogenic tyrosine kinase NPM1-ALK (also known as NPM-ALK)...
  25. pmc EML4-ALK fusion transcript is not found in gastrointestinal and breast cancers
    Y Fukuyoshi
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu 874 0838, Japan
    Br J Cancer 98:1536-9. 2008
    ..The EML4-ALK (EML4: echinoderm microtubule-associated-protein-like 4; ALK: anaplastic lymphoma kinase) fusion gene has been ..
  26. pmc EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
    Jussi P Koivunen
    Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, D820A, 44 Binney Street, Boston, MA 02115, USA
    Clin Cancer Res 14:4275-83. 2008
    The EML4-ALK fusion gene has been detected in approximately 7% of Japanese non-small cell lung cancers (NSCLC). We determined the frequency of EML4-ALK in Caucasian NSCLC and in NSCLC cell lines...
  27. pmc The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL
    Francesco E Boccalatte
    Center for Experimental Research and Medical Studies CERMS, University of Torino, Via Santena 5, 10126 Torino, Italy
    Blood 113:2776-90. 2009
    ..lymphoma represents a subset of neoplasms caused by translocations that juxtapose the anaplastic lymphoma kinase (ALK) to dimerization partners...
  28. doi Oncogenic mutations of ALK kinase in neuroblastoma
    Yuyan Chen
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Nature 455:971-4. 2008
    ..Here we show that the anaplastic lymphoma kinase (ALK), originally identified as a fusion kinase in a subtype of non-Hodgkin's lymphoma (NPM-ALK) and more recently in ..
  29. pmc Activating mutations in ALK provide a therapeutic target in neuroblastoma
    Rani E George
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 455:975-8. 2008
    ..Here we report the detection of previously unknown mutations in the ALK gene, which encodes a receptor tyrosine kinase, in 8% of primary neuroblastomas...
  30. doi KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer
    Kengo Takeuchi
    The Cancer Institute, Japanese Foundation for Cancer Research, Japan
    Clin Cancer Res 15:3143-9. 2009
    EML4-ALK is a transforming fusion tyrosine kinase, several isoforms of which have been identified in lung cancer...
  31. pmc Anaplastic lymphoma kinase: signalling in development and disease
    Ruth H Palmer
    Department of Molecular Biology, Umea University, Umea, Sweden
    Biochem J 420:345-61. 2009
    ..The ALK (anaplastic lymphoma kinase) RTK was originally identified as a member of the insulin receptor subfamily of RTKs ..
  32. doi Mutation-independent anaplastic lymphoma kinase overexpression in poor prognosis neuroblastoma patients
    Lorena Passoni
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Cancer Res 69:7338-46. 2009
    Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase predominantly expressed in the developing nervous system...
  33. doi Molecular pathogenesis of peripheral neuroblastic tumors
    I Janoueix-Lerosey
    INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris Cedex 05, France
    Oncogene 29:1566-79. 2010
    ..Recently, the ALK gene emerged as an important NB gene, being implicated both in sporadic and familial cases...
  34. pmc Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression
    Xuchao Zhang
    Medical Research Center of Guangdong General Hospital, Guangdong Lung Cancer Institute, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
    Mol Cancer 9:188. 2010
    The anaplastic lymphoma kinase (ALK) gene is frequently involved in translocations that lead to gene fusions in a variety of human malignancies, including lymphoma and lung cancer...
  35. pmc Increased ALK gene copy number and amplification are frequent in non-small cell lung cancer
    Marta Salido
    Pathology Department, Hospital del Mar, Parc de Salut Mar, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Thorac Oncol 6:21-7. 2011
    Translocation of the anaplastic lymphoma kinase (ALK) gene is involved in the tumorigenesis of a subset of non-small cell lung carcinomas (NSCLCs) and identifies patients sensitive to ALK inhibitors...
  36. doi Targeting oncogenic ALK: a promising strategy for cancer treatment
    Enrique Grande
    Gastrointestinal and Early Drug Development Unit, Servicio de Oncologia Medica, Hospital Ramon y Cajal, Carretera de Colmenar Viejo Km 9 100, 28034, Madrid, Spain
    Mol Cancer Ther 10:569-79. 2011
    Recently, the anaplastic lymphoma kinase (ALK) has been found to be altered in several solid and hematologic tumors...
  37. doi CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant
    Hiroshi Sakamoto
    Kamakura Research Laboratories, Chugai Pharmaceutical Co, Ltd, 200 Kajiwara, Kamakura, Kanagawa 247 8530, Japan
    Cancer Cell 19:679-90. 2011
    Anaplastic lymphoma kinase (ALK) is a tyrosine kinase that is constitutively activated in certain cancers, following gene alterations such as chromosomal translocation, amplification, or point mutation...
  38. doi High ALK receptor tyrosine kinase expression supersedes ALK mutation as a determining factor of an unfavorable phenotype in primary neuroblastoma
    Johannes H Schulte
    Department of Pediatric Oncology and Hematology, University Children s Hospital, Heidelberg, Germany
    Clin Cancer Res 17:5082-92. 2011
    Genomic alterations of the anaplastic lymphoma kinase (ALK) gene have been postulated to contribute to neuroblastoma pathogenesis...
  39. ncbi ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
    S W Morris
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Oncogene 14:2175-88. 1997
    Anaplastic Lymphoma Kinase (ALK) was originally identified as a member of the insulin receptor subfamily of receptor tyrosine kinases that acquires transforming capability when truncated and fused to nucleophosmin (NPM) in the t(2;5) ..
  40. ncbi Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin
    G E Stoica
    Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    J Biol Chem 276:16772-9. 2001
    ..stretch in the extracellular domain (ECD) of the orphan receptor tyrosine kinase anaplastic lymphoma kinase (ALK)...
  41. ncbi Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth
    Ciaran Powers
    Lombardi Cancer Center, Department of Oncology, Georgetown University, Washington, DC, 20007, USA
    J Biol Chem 277:14153-8. 2002
    ..We have recently identified anaplastic lymphoma kinase (ALK) as a tyrosine kinase receptor for pleiotrophin, a secreted growth factor that is highly expressed during embryonic ..
  42. ncbi Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma
    Rosita L ten Berge
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Blood 99:4540-6. 2002
    ..This prognostic effect was strongly related to anaplastic lymphoma kinase (ALK) status: ALK-positive ALCL had significantly higher levels of active caspase 3, while high expression of the ..
  43. ncbi Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines
    Izumi Miyake
    Cancer Signal Transduction Project, National Cancer Center Research Institute, 5 1 1 Tsukuji, Chuo Ku, Tokyo 104 0045, Japan
    Oncogene 21:5823-34. 2002
    ..Anaplastic lymphoma kinase (ALK), which turned out to be one of these phosphoproteins, was constitutively activated and associated with the PTB ..
  44. ncbi Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma
    Raymond Lai
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 36:939-44. 2005
    ..inhibition of Jak3 down-regulates activated/phosphorylated Stat3 (pStat3), decreases anaplastic lymphoma kinase (ALK) enzymatic activity, and induces cell-cycle arrest and apoptosis in ALK-positive ALCL...
  45. ncbi Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma
    Yajun Han
    Department of Laboratory Medicine and Pathology, Cross Cancer Institute, University of Alberta, 11560 University Avenue, Edmonton, Alberta, Canada T6G 1Z2
    Blood 108:2796-803. 2006
    Previous studies showed that most cases of ALK(+) anaplastic large-cell lymphoma (ALK(+)ALCL) do not express SHP1, a tyrosine phosphatase and an important negative regulator for cellular signaling pathways such as that of JAK/STAT...
  46. ncbi In contrast to agonist monoclonal antibodies, both C-terminal truncated form and full length form of Pleiotrophin failed to activate vertebrate ALK (anaplastic lymphoma kinase)?
    Thomas Mathivet
    INSERM, UMR S 839, Institut du Fer a Moulin, 17 Rue du Fer a Moulin, Paris, F 75005, France
    Cell Signal 19:2434-43. 2007
    Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase essentially and transiently expressed during development in specific regions of the central and peripheral nervous system...
  47. doi [Cytomorphology and molecular characterization of CLTC-ALK rearrangement in 2 cases of ALK-positive diffuse large B-cell lymphoma with extensive bone marrow involvement]
    Hee Suk Choung
    Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Korean J Lab Med 28:89-94. 2008
    Aanaplastic lymphoma kinase (ALK)-positive diffuse large B-cell lymphoma (DLBCL) is an unusual disease entity first reported in 1997 as DLBCL with expression of full-length ALK protein...
  48. doi Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer
    Young Lim Choi
    Division of Functional Genomics and Pulmonary Medicine, Jichi Medical University, Shimotsukeshi, Tochigi, Japan
    Cancer Res 68:4971-6. 2008
    ..cancers (NSCLC) harbors a small inversion within chromosome 2 that gives rise to a transforming fusion gene, EML4-ALK, which encodes an activated protein tyrosine kinase...
  49. pmc Identification of ALK as a major familial neuroblastoma predisposition gene
    Yael P Mosse
    Division of Oncology and Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 455:930-5. 2008
    ..Here we show that germline mutations in the anaplastic lymphoma kinase (ALK) gene explain most hereditary neuroblastomas, and that activating mutations can also be somatically acquired...
  50. doi ALK expression in rhabdomyosarcomas: correlation with histologic subtype and fusion status
    Diana A Corao
    Department of Pathology, A I duPont Hospital for Children, Wilmington, DE, USA
    Pediatr Dev Pathol 12:275-83. 2009
    ..Anaplastic lymphoma kinase immunohistochemistry was performed using anti-human CD246 antibody; cases were considered positive when more than 50% of cells had moderate or intense cytoplasmic and/or ..
  51. doi Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts
    Kengo Takeuchi
    Division of Pathology, The Cancer Institute, Tokyo, Japan
    Clin Cancer Res 14:6618-24. 2008
    EML4-ALK is a fusion-type protein tyrosine kinase that is generated by inv(2)(p21p23) in the genome of non-small cell lung cancer (NSCLC)...
  52. doi Aberrant copy numbers of ALK gene is a frequent genetic alteration in neuroblastomas
    Manish Mani Subramaniam
    Department of Pathology, Medical School, University of Valencia, 46010 Valencia, Spain
    Hum Pathol 40:1638-42. 2009
    A total of 50 neuroblastomas were assessed for frequency of ALK gene copy number aberrations by interphase fluorescence in situ hybridization using a break-apart fluorescence in situ hybridization probe...
  53. pmc Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population
    Scott J Rodig
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Clin Cancer Res 15:5216-23. 2009
    The anaplastic large cell kinase gene (ALK) is rearranged in approximately 5% of lung adenocarcinomas within the Asian population...
  54. doi Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain
    Christian C Lee
    The Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Biochem J 430:425-37. 2010
    b>ALK (anaplastic lymphoma kinase) is an RTK (receptor tyrosine kinase) of the IRK (insulin receptor kinase) superfamily, which share an YXXXYY autophosphorylation motif within their A-loops (activation loops)...
  55. doi Crystal structures of anaplastic lymphoma kinase in complex with ATP competitive inhibitors
    Roberto T Bossi
    Nerviano Medical Sciences S r l, Viale Pasteur 10, 20014 Nerviano MI, Italy
    Biochemistry 49:6813-25. 2010
    Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase involved in the development of several human cancers and, as a result, is a recognized target for the development of small-molecule inhibitors for the treatment of ALK-..
  56. doi Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification
    Sara De Brouwer
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Clin Cancer Res 16:4353-62. 2010
    Activating mutations of the anaplastic lymphoma kinase (ALK) were recently described in neuroblastoma...
  57. doi Renal cell carcinoma with novel VCL-ALK fusion: new representative of ALK-associated tumor spectrum
    Larisa V Debelenko
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN, USA
    Mod Pathol 24:430-42. 2011
    ..The anaplastic lymphoma kinase (ALK) gene has recently been implicated in subsets of pulmonary, esophageal, breast, and colon cancers...
  58. doi Clinicopathologic characteristics and outcomes of patients with anaplastic lymphoma kinase-positive advanced pulmonary adenocarcinoma: suggestion for an effective screening strategy for these tumors
    Youngil Koh
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    J Thorac Oncol 6:905-12. 2011
    ..study was to analyze the clinicopathologic characteristics and outcomes of patients with anaplastic lymphoma kinase (ALK)-positive advanced pulmonary adenocarcinoma and to devise an effective screening strategy to identify such patients.
  59. doi Anaplastic lymphoma kinase translocation: a predictive biomarker of pemetrexed in patients with non-small cell lung cancer
    Jeong Ok Lee
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
    J Thorac Oncol 6:1474-80. 2011
    This study compared the efficacy of pemetrexed in patients with anaplastic lymphoma kinase (ALK)-positive versus ALK-negative (epidermal growth factor receptor [EGFR] mutant or wild type [WT] for both ALK and EGFR) non-small cell lung ..
  60. doi A novel KIF5B-ALK variant in nonsmall cell lung cancer
    Daisy Wing Sze Wong
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Cancer 117:2709-18. 2011
    The anaplastic lymphoma kinase (ALK) gene is involved frequently in chromosomal translocations, resulting in fusion genes with different partners found in various lymphoproliferative conditions...
  61. doi Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition
    Tobias Reiff
    Research Group Developmental Neurobiology, Max Planck Institute for Brain Research, Deutschordenstr 46, 60528, Frankfurt M, Germany
    Development 138:4699-708. 2011
    ..Activating mutations in the gene encoding the ALK tyrosine kinase receptor predispose for NB...
  62. doi Dual IHC and FISH testing for ALK gene rearrangement in lung adenocarcinomas in a routine practice: a French study
    Anne McLeer-Florin
    Plateforme hospitalière de Génétique Moléculaire des Cancers, Department of Hematology, Onco Genetics and Immunology, Päle de Biologie et de Pathologie, CHU A Michallon, Grenoble, France
    J Thorac Oncol 7:348-54. 2012
    In 2011, the French National Cancer Institute recommended ALK-fluorescence in situ hybridization (FISH) testing in all EGFR/KRAS-negative adenocarcinomas by all the hospital molecular genetics platforms of cancers; however, this ..
  63. doi Anaplastic lymphoma kinase aberrations in rhabdomyosarcoma: clinical and prognostic implications
    J Carlijn van Gaal
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Oncol 30:308-15. 2012
    The aim of this study is to investigate anaplastic lymphoma kinase (ALK) protein expression and underlying genetic aberrations in rhabdomyosarcoma (RMS), with special attention to clinical and prognostic implications.
  64. pmc Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies
    Doron Lipson
    Foundation Medicine, Cambridge, Massachusetts, USA
    Nat Med 18:382-4. 2012
    ..at least one clinically relevant genomic alteration in 59% of the samples and revealed two gene fusions, C2orf44-ALK in a colorectal cancer sample and KIF5B-RET in a lung adenocarcinoma...
  65. doi RET, ROS1 and ALK fusions in lung cancer
    Kengo Takeuchi
    Pathology Project for Molecular Targets, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Nat Med 18:378-81. 2012
    ..and histopathology-based screening system, we performed a screening for fusions of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1, receptor tyrosine kinase (ROS1) in 1,529 lung cancers and identified 44 ALK-fusion-positive ..
  66. doi Multiparametric molecular characterization of pulmonary sarcomatoid carcinoma reveals a nonrandom amplification of anaplastic lymphoma kinase (ALK) gene
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS National Cancer Institute, Milan, Italy
    Lung Cancer 77:507-14. 2012
    ..Genetic alterations for targeting therapy are largely unexplored issues in pulmonary sarcomatoid carcinoma (PSC), a life-threatening tumor subset...
  67. pmc Rearranged anaplastic lymphoma kinase (ALK) gene in adult-onset papillary thyroid cancer amongst atomic bomb survivors
    Kiyohiro Hamatani
    Department of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Minami Ku, Hiroshima, Japan
    Thyroid 22:1153-9. 2012
    ..However, in ABS with PTC, the relationship between the presence of the anaplastic lymphoma kinase (ALK) gene fused with other gene partners and radiation exposure has received little study...
  68. doi Characterization of rearrangements involving the ALK gene reveals a novel truncated form associated with tumor aggressiveness in neuroblastoma
    Alex Cazes
    INSERM U830, Institut Curie, Centre de Recherche, Paris, France
    Cancer Res 73:195-204. 2013
    Activating mutations of the ALK gene have been identified in sporadic and familial cases of neuroblastoma (NB), a cancer of the peripheral nervous system, and are thought to be the primary mechanism of oncogenic activation of this ..
  69. doi Anaplastic lymphoma kinase status in rhabdomyosarcomas
    Akihiko Yoshida
    Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
    Mod Pathol 26:772-81. 2013
    ..Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that is a potential target for specific inhibitors...
  70. doi Novel adaptor protein Shf interacts with ALK receptor and negatively regulates its downstream signals in neuroblastoma
    Daisuke Takagi
    Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan
    Cancer Sci 104:563-72. 2013
    ..In this study, we found that Shf interacted with anaplastic lymphoma kinase (ALK), an oncogenic receptor tyrosine kinase in neuroblastoma...
  71. doi Prognostic implications of anaplastic lymphoma kinase gene aberrations in rhabdomyosarcoma; an immunohistochemical and fluorescence in situ hybridisation study
    Jae Seok Lee
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    J Clin Pathol 67:33-9. 2014
    We investigated the diagnostic and prognostic usefulness of anaplastic lymphoma kinase (ALK) expression in Asian rhabdomyosarcoma (RMS) patients.
  72. pmc ALK-rearranged lung cancer in Chinese: a comprehensive assessment of clinicopathology, IHC, FISH and RT-PCR
    Yuan Li
    Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
    PLoS ONE 8:e69016. 2013
    Approximately 3-7% of non-small cell lung cancers harbor an anaplastic lymphoma kinase (ALK) gene fusion, constituting a new molecular subtype of lung cancer that responds to crizotinib, an ALK inhibitor...
  73. doi Lung cancers with concomitant EGFR mutations and ALK rearrangements: diverse responses to EGFR-TKI and crizotinib in relation to diverse receptors phosphorylation
    Jin Ji Yang
    Authors Affiliations Division of Pulmonary Oncology, Cancer Center, Guangdong Lung Cancer Institute Medical Research Center, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou and State Key Laboratory of Southern China, The Chinese University of Hong Kong, Sir YK Pau Cancer Center, Prince of Wales Hospital, Hong Kong, China
    Clin Cancer Res 20:1383-92. 2014
    ..the incidence of concomitant epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements in Chinese patients with non-small cell lung cancer (NSCLC), and assessed responses to EGFR ..
  74. ncbi Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
    S W Morris
    Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, TN 38105
    Science 263:1281-4. 1994
    ..the NPM nucleolar phosphoprotein gene on chromosome 5q35 to a previously unidentified protein tyrosine kinase gene, ALK, on chromosome 2p23...
  75. ncbi Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system
    T Iwahara
    Department of Oncology, Institute of Medical Science, University of Tokyo, Japan
    Oncogene 14:439-49. 1997
    ..The translocation creates a fusion gene consisting of the alk (anaplastic lymphoma kinase) gene and the nucelophosmin (npm) gene: the 3' half of alk derived from chromosome 2 is ..
  76. ncbi Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
    Alberto Zamo
    Department of Pathology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Oncogene 21:1038-47. 2002
    The anaplastic lymphoma kinase (ALK) gene is characteristically translocated in Anaplastic Large Cell Lymphomas (ALCL) and the juxtaposition of the ALK gene to multiple partners results in its constitutive protein tyrosine kinase ..
  77. ncbi Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin
    Paolo Bonvini
    Clinica di Oncoematologia Pediatrica, Azienda Ospedaliera Universita di Padova, 35128 Padua, Italy
    Cancer Res 62:1559-66. 2002
    Anaplastic large cell lymphomas (ALCL) are characterized by the expression of a chimeric protein, NPM-ALK, which originates from fusion of the nucleophosmin (NPM) and the membrane receptor anaplastic lymphoma kinase (ALK) genes...
  78. pmc Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity
    Luis Hernandez
    Centro de Investigación delCáncer, Centro Superior de Investigaciones Científicas University of Salamanca, Salamanca, Spain
    Am J Pathol 160:1487-94. 2002
    ..Anaplastic large cell lymphomas are associated with chromosomal aberrations involving the anaplastic lymphoma kinase (ALK) gene at 2p23 that result in the expression of novel chimeric ALK proteins with transforming properties...
  79. ncbi Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types
    Gerald E Stoica
    Lombardi Cancer Center, Georgetown University, Washington, D C 20007, USA
    J Biol Chem 277:35990-8. 2002
    ..MK binds to anaplastic lymphoma kinase (ALK), the receptor for PTN, with an apparent K(d) of 170 pm in intact cells, and this receptor binding of MK is ..
  80. pmc The nucleophosmin-anaplastic lymphoma kinase fusion protein induces c-Myc expression in pediatric anaplastic large cell lymphomas
    Elizabeth A Raetz
    Center for Children at the Huntsman Cancer Institute, Salt Lake City, Utah, USA
    Am J Pathol 161:875-83. 2002
    ..chromosomal translocation that juxtaposes the dimerization domain of nucleophosmin with anaplastic lymphoma kinase (ALK)...
  81. ncbi Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA)
    Tao Ouyang
    Department of Internal Medicine III, Laboratory of Leukemogenesis, Technical University of Munich, 81675 Munich, Germany
    J Biol Chem 278:30028-36. 2003
    ..t(2;5) leading to expression of the oncogenic tyrosine kinase nucleophosmin-anaplastic lymphoma kinase (NPM-ALK). NPM-ALK is capable of transforming fibroblasts and lymphocytes in vitro and of causing lymphomas in mice...
  82. ncbi ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements: report of 6 cases
    Randy D Gascoyne
    Department of Oncogeneiss and Signaling in Hematopoietic Cells, Instiut National de la Santé et de la Recherche Médicale U 563, Centre de Physiopatholgie de Toulouse Purpan, France
    Blood 102:2568-73. 2003
    Expression of ALK protein by lymphoid cells and the description of variant anaplastic lymphoma kinase (ALK) translocations have typically been restricted to cases of T-cell and null anaplastic large-cell lymphoma (ALCL)...
  83. ncbi Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma
    Laurence Lamant
    INSERM U 563, Department of Oncogenesis and Signaling in Hematopoietic Cells, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    Genes Chromosomes Cancer 37:427-32. 2003
    In anaplastic large cell lymphoma, the ALK gene at 2p23 is known to be fused to NPM, TPM3, TPM4, TFG, ATIC, CLTC, MSN, and ALO17...
  84. ncbi NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a
    Ting Lei Gu
    Division of Hematology, Brigham and Women s Hospital Harvard Medical School, 75 Francis Street, Boston, MA, USA
    Blood 103:4622-9. 2004
    ..which results in the generation of the fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)...
  85. ncbi ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth
    Akira Motegi
    Division of Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, 108 8639, Japan
    J Cell Sci 117:3319-29. 2004
    Anaplastic lymphoma kinase (ALK) is a receptor-type protein tyrosine kinase that is expressed preferentially in neurons of the central and peripheral nervous systems at late embryonic stages...
  86. ncbi The emerging normal and disease-related roles of anaplastic lymphoma kinase
    K Pulford
    Leukaemia Research Fund Immunodiagnostics Unit, Nuffield Department, Clinical Laboratory Sciences, Room 5501, Level 5, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Cell Mol Life Sci 61:2939-53. 2004
    Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase, the normal role of which remains to be completely elucidated...
  87. ncbi Truncated ALK derived from chromosomal translocation t(2;5)(p23;q35) binds to the SH3 domain of p85-PI3K
    Doris Polgar
    Institute of Clinical Pathology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Mutat Res 570:9-15. 2005
    ..The fusion of the tyrosine kinase gene-ALK (anaplastic lymphoma kinase) on chromosome 2p23 to the NPM (nucleophosmin/B23) gene on chromosome 5q35 results in a ..
  88. ncbi Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor
    Ioannis Panagopoulos
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Int J Cancer 118:1181-6. 2006
    ..Immunostaining with monoclonal mouse anti-human CD246 ALK Protein showed diffuse cytoplasmic positivity...
  89. ncbi Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells
    Weihua Wan
    Oncology, Cephalon Inc, 145 Brandywine Pkwy, West Chester, PA 19380, USA
    Blood 107:1617-23. 2006
    The roles of aberrant expression of constitutively active ALK chimeric proteins in the pathogenesis of anaplastic large-cell lymphoma (ALCL) have been well defined; nevertheless, the notion that ALK is a molecular target for the ..
  90. ncbi Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population
    H Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Neural Transm (Vienna) 113:1569-73. 2006
    We examined, for the first time, the possible association between schizophrenia and the anaplastic lymphoma kinase (ALK) gene which plays an important role in neurodevelopment...
  91. ncbi A "liaison dangereuse" between AUF1/hnRNPD and the oncogenic tyrosine kinase NPM-ALK
    Mohamad Fawal
    Centre de Biologie du Developpement, CNRS UMR 5547, IFR 109, Universite Paul Sabatier, Bâtiment 4R3, 118 route de Narbonne, 31062 Toulouse Cedex 4, France
    Blood 108:2780-8. 2006
    Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) is a chimeric protein expressed in a subset of cases of anaplastic large cell lymphoma (ALCL) for which constitutive expression represents a key oncogenic event...
  92. ncbi Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase
    A H Kuo
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Oncogene 26:859-69. 2007
    Anaplastic lymphoma kinase (ALK) is a transmembrane receptor tyrosine kinase in the insulin receptor superfamily...
  93. pmc Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage
    Jaouhar Mourali
    INSERM U563, CPTP, CHU Purpan, BP3028, 31024 Toulouse Cedex 3, France
    Mol Cell Biol 26:6209-22. 2006
    Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase, initially discovered as part of the NPM-ALK fusion protein, resulting from the t(2;5) translocation that is frequently associated with anaplastic large-cell lymphomas...
  94. ncbi Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation
    Pablo Perez-Pinera
    Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 282:28683-90. 2007
    Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) first discovered as the constitutively active nucleophosmin-ALK oncoprotein in anaplastic large cell lymphomas (ALCL)...
  95. ncbi The anaplastic lymphoma kinase in the pathogenesis of cancer
    Roberto Chiarle
    Center for Experimental Research and Medical Studies CERMS, University of Torino, Via Santena 7, 10126, Italy
    Nat Rev Cancer 8:11-23. 2008
    ..The anaplastic lymphoma kinase (ALK) is the oncogene of most anaplastic large cell lymphomas (ALCL), driving transformation through many molecular ..
  96. doi EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers
    Kentaro Inamura
    Department of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research JFCR, Tokyo, Japan
    J Thorac Oncol 3:13-7. 2008
    ..product between the echinoderm microtubule-associated protein-like4 (EML4) and the anaplastic lymphoma kinase (ALK) in non-small cell lung cancers (NSCLCs)...
  97. doi ALK-positive diffuse large B-cell lymphoma: report of three cases
    Hyoun Wook Lee
    Department of Pathology, Dong A University, Pusan, Korea
    Hematol Oncol 26:108-13. 2008
    Diffuse large B-cell lymphoma positive for anaplastic lymphoma kinase (ALK(+) DLBCL) is a rare variant of diffuse large B-cell lymphoma, with characteristic morphological, immunohistochemical and cytogenetic features...
  98. pmc EML4-ALK fusion lung cancer: a rare acquired event
    Sven Perner
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical Center, New York, NY, USA
    Neoplasia 10:298-302. 2008
    A recurrent gene fusion between EML4 and ALK in 6.7% of non-small cell lung cancers (NSCLCs) and NKX2-1 (TTF1, TITF1) high-level amplifications in 12% of adenocarcinomas of the lung were independently reported recently...
  99. doi Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
    Ultan McDermott
    Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Cancer Res 68:3389-95. 2008
    ..derived from a variety of human cancers, we found that a selective inhibitor of the anaplastic lymphoma kinase (ALK) potently suppressed growth of a small subset of tumor cells...
  100. doi Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
    Isabelle Janoueix-Lerosey
    Institut Curie, Centre de Recherche, and INSERM, U830, 26 Rue d Ulm, Paris F 75248, France
    Nature 455:967-70. 2008
    ..Copy number increase at the locus encoding the anaplastic lymphoma kinase (ALK) tyrosine kinase receptor was observed recurrently...
  101. pmc The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation
    Chiara Ambrogio
    Department of Biomedical Sciences and Human Oncology, Center for Experimental Research and Medical Studies, University of Torino, Turin, Italy
    Cancer Res 68:8899-907. 2008
    ..oncogenic fusion proteins derived from chromosomal translocations or inversions of the anaplastic lymphoma kinase (ALK) gene. The proliferation and survival of ALCL cells are determined by the ALK activity...

Research Grants73

  1. NATHANAEL SCHIANDER GRAY; Fiscal Year: 2015
    ..anti-cancer activity of protein kinase inhibitors that target specific driver-mutations such as Bcr- Abl, EML4-ALK, mutant EGFR and V600E b-raf is revolutionizing cancer drug discovery...
  2. Hesham M Amin; Fiscal Year: 2015
    ..provided by applicant): Nucleophosmin-anaplastic lymphoma kinase-expressing anaplastic large-cell lymphoma (NPM-ALK+ ALCL) is an aggressive type of T-cell lymphoma...
  3. The Role of NPM-ALK Signaling in Tumor Cell Metabolism
    SCOTT RP MCDONNELL; Fiscal Year: 2012
    ..resulting in the aberrant expression of the fusion protein nucleophosmin - anaplastic lymphoma kinase (NPM-ALK)...
  4. Novel role of STAT3 in NPM/ALK-induced oncogenesis
    Mariusz A Wasik; Fiscal Year: 2013
    This proposal is aimed at a better understanding of the oncogenic role of anaplastic large cell lymphoma kinase (ALK)...
  5. Proteomic biomarkers of ALK+ lymphoma
    Megan S Lim; Fiscal Year: 2013
    ..ALCL) is a distinct subtype of peripheral T-cell lymphomas harboring chromosomal translocations involving the ALK tyrosine kinase. ALCL represents about 10% of all childhood non-Hodgkin lymphoma (NHL)...
  6. Jie Wu; Fiscal Year: 2014
    ..New treatment paradigms incorporating inhibitors to specific driver mutations, such as EGFR and ALK, have shown improved clinical benefits...
  7. Youli Zu; Fiscal Year: 2014
    ..distinct expression of CD30 proteins on the cell surface and abnormal expression of the anaplastic lymphoma kinase (ALK) gene due to chromosomal translocations...
  8. Arul M Chinnaiyan; Fiscal Year: 2015
    ..Identification of specific alterations such as EGFR mutations and more recently, ALK kinase gene fusions, have lead to the more efficacious treatment of patients whose lung adenocarcinomas contain ..
  9. Marc Ladanyi; Fiscal Year: 2016
    ..Our roles in the development of EGFR and ALK kinase inhibitors and the discoveries that mutations in EGFR and KRAS genes and ALK re-arrangements underlie ..
  10. Alice T Shaw; Fiscal Year: 2016
    ..lung cancers and more recently, crizotinib (PF-02341066) for lung cancers harboring chromosomal rearrangements of ALK (anaplastic lymphoma kinase)...
  11. Role of MAP kinases in anaplastic large cell lymphoma
    Youli Zu; Fiscal Year: 2009
    ..in a fusion gene composed of nucleophosmin (NPM) and a truncated tyrosine kinase, named anaplastic lymphoma kinase (ALK). Abnormal expression of the NPM-ALK fusion protein leads to the auto-activation of ALK...
  12. Peter S Hammerman; Fiscal Year: 2016
    ..successful use of highly effective targeted therapeutic agents in this disease, namely inhibitors of the EGFR and ALK kinases...
  13. Signal Transduction in Lymphoma
    Christopher Carpenter; Fiscal Year: 2006
    ..ALCL in the non-HIV population are caused by activation of the protein tyrosine kinase anaplastic lymphoma kinase (ALK)...
  14. NPM-ALK & CD30 Signaling in Anaplastic Cell Lymphoma
    Henry Koon; Fiscal Year: 2007
    ..translocation which produces a fusion protein between Nucleophosmin on chromosome 5 and Anaplastic Lymphoma Kinase (ALK) on chromosome 2. NPM-ALK is an oncogenic tyrosine kinase that activates multiple signal transduction pathways...
  15. Suppression of Ocular Scarring - Controlled Delivery of an ALK-5 Inhibitor
    Hiroshi Nakamura; Fiscal Year: 2013
    ..Recently, inhibitors of activin receptor-like kinase 5 (ALK-5, also called TGF-2 receptor type I) have been described to be effective suppressors of TGF-2 activity...
  16. Receptor Tyrosine Kinase Sorting and Transactivation in Endosomes
    MARK LINDSAY GRIMES; Fiscal Year: 2010
    ..there crosstalk or transactivation between TrkA and another receptor tyrosine kinase, anaplastic lymphoma kinase (ALK)? ALK is frequently mutated in neuroblastoma, highly tyrosine phosphorylated in neuroblastoma cell lines, and ..
  17. Jeffrey A Jones; Fiscal Year: 2016
    ..TGF-b signaling pathway during TAA development revealed a shift in signaling from a TGF-bRI-mediated pathway to an ALK-1- mediated pathway...
  18. Kendal Broadie; Fiscal Year: 2016
    ..C6 carbon;3) the secreted Jelly Belly (Jeb) trans-synaptic signal binding to the 4) Anaplastic Lymphoma Kinase (Alk) receptor tyrosine kinase, both of which are regulated by 5) GlcNAc Transferase 1 (Mgat1) and 6) secreted Mind-the-..
  19. Pasi A Janne; Fiscal Year: 2016
    ..Rearrangements of the anaplastic lymphoma kinase (ALK) occur in ~ 3% of NSCLC patients...
  20. The 2nd AACR-IASLC Joint Conference on the Molecular Origins of Lung Cancer: Pro
    MARGARET FOTI; Fiscal Year: 2011
    ..Similarly in 2010, the molecular subtype of NSCLC with ALK fusions emerged to the forefront as a clinically relevant and treatable oncogenic mutation...
  21. AMY WOLVEN LASEK; Fiscal Year: 2016
    ..The experiments proposed in the second aim will test if a candidate estrogen-regulated gene, Alk, mediates the effect of estrogen in increasing cocaine sensitization and conditioned place preference, by using a ..
  22. Jing Hong Wang; Fiscal Year: 2016
    ..and lymphomas, and increasingly found in solid tumors such as TMPRSS2-ETS translocation in prostate cancer and ALK translocations in lung cancer...
  23. OTHER FUNCTIONS - R&D BIOMEDICAL (BASIC RESEARCH)
    DR DAVID HOUT; Fiscal Year: 2012
    ..non-small cell lung cancer (NSCLC) in type and mainly driven by three mutually exclusive oncogenes, EGFR, KRAS and ALK (collectively between 30-60% of all NSCLC cases)...
  24. OTHER FUNCTIONS - R&D BIOMEDICAL (BASIC RESEARCH)
    DR DAVID HOUT; Fiscal Year: 2013
    ..non-small cell lung cancer (NSCLC) in type and mainly driven by three mutually exclusive oncogenes, EGFR, KRAS and ALK (collectively between 30-60% of all NSCLC cases)...
  25. Discovery of Rational Companion Therapeutic Targets to Optimize Cancer Treatment
    Trever G Bivona; Fiscal Year: 2012
    ..In some genetically defined subsets of cancer patients whose tumors harbor an oncogenic driver (e.g. mutant EGFR, ALK gene fusions, mutant B-RAF), pharmacologic oncogene inhibition has become standard of care...
  26. Ramani Ramchandran; Fiscal Year: 2014
    ..Our central hypothesis is that "transforming growth factor-beta (TGF-) ligand interacts with specific receptors (ALK-1/ALK-5) on endothelial cells transmitting signals via Snrk-1 and Dusp-5 to common substrate Rho-associated, coiled-..
  27. MIS Regulation of Leydig Cell Development
    MARY MIN CHIN LEE; Fiscal Year: 2010
    ..The Specific Aims of this grant are: 1. to identify the MIS type I receptors by experimental ablation of ALK function in Leydig cells;2...
  28. Pasi A Janne; Fiscal Year: 2016
    ..include somatic mutations in the epidermal growth factor receptor (EGFR) and in anaplastic lymphoma kinase (ALK) rearrangements...
  29. Regulation of brush border cortical F-actin by sphingomyelinase
    David E Saslowsky; Fiscal Year: 2010
    ..I recently found that polarized intestinal T84 cells express an alkaline isoform of SMase (alk-SMase) as an apical ecto-enzyme that uses SM in the outer PM leaflet as substrate under steady-state conditions...
  30. Shizhen Zhu; Fiscal Year: 2014
    ..genomic resequencing of high-risk neuroblastoma has uncovered three main classes of mutations: those activating the ALK tyrosine kinase (8- 10% of cases), those activating the SHP2 phosphatase (2-3%), and microdeletions involving the ..
  31. Dan Theodorescu; Fiscal Year: 2016
    ..by our members'lead roles in a lung cancer SPORE, LIVESTRONG Center of Excellence, biomarker development (ALK rearrangement, EGFR) for individualized therapy by our Pathology Shared Resource and development of a top Animal ..
  32. Yael P Mosse; Fiscal Year: 2016
    ..We have recently discovered that germline mutations in the anaplastic lymphoma kinase (ALK) gene explain most hereditary neuroblastomas, and that activating mutations can also be somatically acquired...
  33. Predictive biomarker development in lung cancer: ROS1 chromosomal rearrangements
    Anthony John Iafrate; Fiscal Year: 2012
    ..learned from our successful implementation of diagnostics to detect chromosomal rearrangements involving the ALK gene, we will identify, test, validate, and implement the optimal ROS1 assay platform...
  34. WILLIAM M PARKINSON; Fiscal Year: 2015
    ..3) Loss of Alk in Mgat1 null NMJs is caused by loss of Mgat1-dependent N-glycosylation and is causative for aspects of the Mgat1 ..
  35. Modulation of Bone Morphogenic Protein signaling for cancer immunotherapy
    PIOTR J KRAJ; Fiscal Year: 2013
    ..We have found that Bone Morphogenic Protein Receptor 1a (BMPR1a, Alk-3), expressed by activated effector and Foxp3+ regulatory CD4+ T cells (TR), modulates the functions of both cell ..
  36. Combined PKCiota and mTOR inhibition for treatment of advanced squamous lung canc
    Alan P Fields; Fiscal Year: 2012
    ..New approaches are targeted against growth factors (EGF, VEGF), gene translocations (EML4-ALK), and oncogenes (RAS), but are applicable most commonly only to non-squamous subtypes of NSCLC...
  37. Companion Diagnostic for ALK Mutations
    DAVID HOUT; Fiscal Year: 2010
    ..Anaplastic lymphoma kinase (ALK) fusion oncogenes have emerged as an important cause of lung cancer, and ALK inhibitor programs (by Pfizer, Lil ly, ..
  38. AMY WOLVEN LASEK; Fiscal Year: 2016
    ..The genes include Lmo3 and Lmo4, which encode transcriptional regulators, Alk, which encodes a receptor tyrosine kinase, and Mdk, which encodes a ligand that regulates the Alk gene product...
  39. TGF-beta receptor signaling in scleroderma
    MARIA TROJANOWSKA TROJANOWSKA; Fiscal Year: 2012
    ..we have elucidated a novel profibrotic signaling pathway downstream from the TGF-2 receptor type I (TGF-2RI or ALK 5) that is triggered by an altered ratio of the TGF-2 receptors and leads to activation of Smad1 and ERK1/2 ..
  40. William A Weiss; Fiscal Year: 2016
    ..In a tumor with few prominent kinases, how is PI3K activated? How do activation of ALK and loss of NF1 (which contribute to progression in neuroblastoma) influence response to PI3K inhibition? Can we ..
  41. Rani E George; Fiscal Year: 2015
    ..We recently discovered activating somatic mutations in the ALK receptor tyrosine kinase gene in primary neuroblastomas...
  42. Pasi A Janne; Fiscal Year: 2016
    ..Rearrangements in ALK, ROS1 and RET, all of which lead to oncogenic fusion proteins, have been reported and evaluation of whether kinase ..
  43. Ira J Blader; Fiscal Year: 2016
    ..Decreases in PHD2 protein is achieved by the parasite signaling though the Activin Like Kinase (ALK) receptor family. Significantly, inhibition of ALK signaling severely impairs parasite growth...
  44. Phase 1 Study of ALK001 for Stargardt Disease
    Ilyas Washington; Fiscal Year: 2013
    ..b>ALK-001, is vitamin A specifically enriched with deuterium at a position to slow the formation of toxic vitamin A ..
  45. Function of TbRIII as a BMP Co-receptor in Human Cancer
    Gerard C Blobe; Fiscal Year: 2013
    ..with loss of autocrine BMP responsiveness, in part through loss of T[unreadable]RIII expression and decreased ALK-6 signaling, facilitating cancer initiation and elevated BMP levels, in part through loss of sT[unreadable]RIII ..
  46. LONGITUDINAL STUDY OF BONE DENSITY IN ANOREXIA NERVOSA
    MICHAEL PERTSCHUK; Fiscal Year: 1993
    ..Baseline values will be obtained including serum pregnancy test, estradiol, 25-OH-Vit D, Ca, inorganic PO4, alk phosphatase, T4, T3Ru, TSH, PTH, BUN, creatinine, TIBC, total protein and 24 hour urine cortisol and creatinine...
  47. Development of a Clincial Diagnostic Assay for ALK Inhibitor Mutations
    DAVID HOUT; Fiscal Year: 2013
    Despite the marked anti-tumor responses to Xalkori observed with ALK-driven tumors, most patients eventually experience disease progression as a consequence of resistance to the ALK inhibitor...
  48. OTHER FUNCTIONS DEVELOPMENT OF A COMPANION DIAGNOSTIC FOR ALK MUTATIONS.
    DAVID HOUT; Fiscal Year: 2012
    Constitutively activated forms of ALK caused by genetic aberrations have been shown to cause an expanding variety of human cancers...
  49. Ether Linked Lipids and Signaling in Breast Tumor Cells
    ROBERT WYKLE; Fiscal Year: 2004
    ..that the two cell lines that are estrogen receptor-positive (ER+), MCF-7 and T47D, contain only traces of alkyl or alk-1-enyl (plasmalogens) species in PC and similarly low levels in FE...
  50. TAS::75 0849::TAS SBIR TOPIC 277 - DEVELOPMENT OF A CLINICAL DIAGNOSTIC ASSAY FO
    DAVID HOUT; Fiscal Year: 2011
    ..Anaplastic lymphoma kinase (ALK) was discovered by Dr. Stephan Morris (Insight Genetics[unreadable] collaborator on these studies)...
  51. GENETIC ASPECTS OF PULMONARY HYPERTENSION
    Jane Morse; Fiscal Year: 2007
    ..and 5 hereditary hemorrhagic telangiectasia (HHT1) families, four have mutations in activin-like receptor 1 (ALK-1), another gene associated with PPH...
  52. Molecular basis for vascular malformations
    Dean Li; Fiscal Year: 2006
    ..the KRIT-1 gene in a screen for genes differentially expressed in mice lacking activin receptor-like kinase 1, Alk-1...
  53. Left-Right Axis Determination and Cardiac Development
    ANN RAMSDELL; Fiscal Year: 2005
    ..analyses, Aim 1 will identify cell-cell signals important for LR axis formation by defining ligands for the ALK pathways...
  54. GENETICS OF HEREDITARY HEMORRHAGIC TELANGIECTASIA
    Douglas Marchuk; Fiscal Year: 2004
    ..of different ligand affinity, and that endoglin must either potentate ALK1-associated signaling or interfere with ALK-5-associated signaling...
  55. Pericytes in Pathogenesis of Germinal-Matrix Hemorrhage
    Praveen Ballabh; Fiscal Year: 2006
    ..determine the expression of angiopoietin, PDGF-B, TGF-beta and their respective receptors Tie-1, -2, PDGFR-beta, ALK-1 and -5 in the germinal matrix compared to cortex and white matter of the frontal lobe in human fetuses and ..
  56. PLASMALOGENS AND RELATED ETHER LIPIDS IN CANCER CELLS
    FRED SNYDER; Fiscal Year: 1990
    ..pathways for glycerolipids that determine membrane lipid composition with respect to the diacyl-, alkylacyl-, and alk-l-enylacyl- subclasses of phospholipids, and (3) to characterize the properties and to delineate the reaction ..
  57. BMP SIGNALING DURING HUMAN BONE REPAIR
    PHOEBE LEBOY; Fiscal Year: 2004
    ..Furthermore, in contrast to rat and mouse stem cells and mature human osteoblasts, MSC from human marrow lack ALK-6, a receptor utilized by BMP-2 and BMP-4 and implicated in bone formation...
  58. Genetics of Pulmonary Hypertension in Mice
    Karen Fagan; Fiscal Year: 2006
    ..Mutations in two genes in the transforming growth factor-beta superfamily, BMPRII and ALK-1, have been identified in patients with hereditary and sporadic PAH...
  59. NPM ALK mediated transformation of T lymphocytes
    David Levy; Fiscal Year: 2006
    ..by applicant) The overall goal of this application is to study the molecular and biological role of the NPM-ALK fusion product derived from the translocation 1(2;5) characteristic of anaplastic large cell lymphomas (ALCL)...
  60. REGULATION OF ACTIVIN FUNCTION BY SMAD7
    Yan Chen; Fiscal Year: 2003
    ..We will determine if the interaction of Smad7 with activin type I receptor ALK-4 is required for the inhibitory activity of Smad7...
  61. The role of Anaplastic Lymphoma Kinase in motor neuron survival
    Frances Lefcort; Fiscal Year: 2010
    ..proposal is to determine the function of a relatively novel receptor tyrosine kinase, Anaplastic Lymphoma Kinase (ALK), in spinal motor neurons...
  62. Transgenic Murine Model of Brain Vascular Malformation
    Guo Yuan Yang; Fiscal Year: 2004
    ..Furthermore, transforming growth factor beta-1 (TGF-b1) activates TGF-b1, ALK-5, and Smad 2/3 signal pathways, promoting regional angiogenesis formation in the brain tissue...
  63. Novel Roles for beta-arrestin2 in TGF-beta mediated Endoglin Signaling
    NAM LEE; Fiscal Year: 2009
    ..mediated by the predominantly endothelial cell-specific TGF-p receptor complex, endoglin (a type III receptor) and ALK-1 (a type I receptor)...