alanine glyoxylate aminotransferase 2

Summary

Gene Symbol: alanine glyoxylate aminotransferase 2
Description: alanine--glyoxylate aminotransferase 2
Alias: AGT2, DAIBAT, alanine--glyoxylate aminotransferase 2, mitochondrial, (R)-3-amino-2-methylpropionate--pyruvate transaminase, beta-ALAAT II, beta-alanine-pyruvate aminotransferase
Species: human

Top Publications

  1. pmc Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production
    Roman N Rodionov
    Department of Internal Medicine, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 285:5385-91. 2010
  2. doi A genome-wide association study of metabolic traits in human urine
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 43:565-9. 2011
  3. pmc A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection
    George Nicholson
    Department of Statistics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 7:e1002270. 2011
  4. doi Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure
    Ben Caplin
    Nitric Oxide Signalling Group, Medical Research Council Clinical Sciences Center, Imperial College London, London, United Kingdom
    Arterioscler Thromb Vasc Biol 32:2892-900. 2012
  5. pmc A genome-wide association study of the human metabolome in a community-based cohort
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Metab 18:130-43. 2013
  6. doi Missense variants of the alanine:glyoxylate aminotransferase 2 gene are not associated with Japanese schizophrenia patients
    Yuta Yoshino
    Department of Neuropsychiatry, Molecule Function, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 53:137-41. 2014
  7. doi Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes
    Maike Anderssohn
    Corresponding author Maike Anderssohn
    Diabetes Care 37:846-54. 2014
  8. ncbi Association of the AGXT2 V140I polymorphism with risk for coronary heart disease in a Chinese population
    Ji Peng Zhou
    Department of Clinical Pharmacology, Xiangya Hospital, Central South University
    J Atheroscler Thromb 21:1022-30. 2014
  9. pmc Modulation of renin angiotensin system predominantly alters sclerotic phenotype of glomeruli in HIVAN
    Andrei Plagov
    Renal Molecular Research Laboratory, Feinstein Institute for Medical Research, Manhasset, NY, USA
    Histol Histopathol 29:1575-81. 2014
  10. doi Role of alanine:glyoxylate aminotransferase 2 in metabolism of asymmetric dimethylarginine in the settings of asymmetric dimethylarginine overload and bilateral nephrectomy
    Roman N Rodionov
    University Center for Vascular Medicine, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Nephrol Dial Transplant 29:2035-42. 2014

Scientific Experts

  • Jens Martens-Lobenhoffer
  • L Rochette
  • Renke Maas
  • George Nicholson
  • Karsten Suhre
  • Roman N Rodionov
  • Anja Kittel
  • Norbert Weiss
  • Natalia Jarzebska
  • Ilkka Seppälä
  • Stefanie M Bode-Boger
  • Y Yoshino
  • Xiao Lei Hu
  • Silke Brilloff
  • Ji Peng Zhou
  • Maren Mieth
  • Dmitry V Burdin
  • Vito Porcelli
  • Reijo Laaksonen
  • Xiao Ping Chen
  • Winfried März
  • Mika Kahonen
  • Kari Matti Mäkelä
  • Marcus E Kleber
  • Terho Lehtimaki
  • Niku Oksala
  • Da Bin Kuang
  • Wei Zhang
  • Tuomas Koskinen
  • Jussi A Hernesniemi
  • Tian lun Yang
  • Leo Pekka Lyytikäinen
  • M Igase
  • M Abe
  • S Ochi
  • T Miki
  • Maike Anderssohn
  • James Leiper
  • Y Tabara
  • T Mori
  • K Kohara
  • Rico Rueedi
  • S Ueno
  • Y Mori
  • K Yamashita
  • Yuta Yoshino
  • Andrei Plagov
  • Jorg Konig
  • Bernd Hohenstein
  • Eugene P Rhee
  • Ben Caplin
  • Steven R Lentz
  • C U Ingram
  • Christopher J Danpure
  • Paul R S Baker
  • Li Ming Peng
  • Hong Qi
  • Anton V Demyanov
  • Barbara Cellini
  • Alexey A Soshnev
  • Cathie Sudlow
  • Chad Brocker
  • Efthymia Vlachopoulou
  • Steve Bevan
  • Xi Li
  • Juha Sinisalo
  • Nikolay Samusik
  • Hong Hao Zhou
  • Stefan R Bornstein
  • Peter M Rothwell
  • Anton Demyanov
  • Martin Dichgans
  • Hubert Scharnagl
  • Ellen I Closs
  • Dmitrii Burdin
  • Hugh S Markus
  • Alexey A Kolobov
  • Antonella Longo
  • Frank Gonzalez
  • Luigi Palmieri
  • Elisa Oppici
  • Aaron H Liepman
  • Ferdinando Palmieri
  • Graciela E Delgado
  • Anne Kolouschek
  • Nina Mononen
  • Jian Xia
  • Markus R Heinrich
  • Rainer H Boger
  • Andreas Tomaschitz

Detail Information

Publications32

  1. pmc Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production
    Roman N Rodionov
    Department of Internal Medicine, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 285:5385-91. 2010
    ..We conclude that mitochondrially localized human AGXT2 is able to effectively metabolize ADMA in vivo resulting in decreased ADMA levels and improved endothelial NO production...
  2. doi A genome-wide association study of metabolic traits in human urine
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 43:565-9. 2011
    ..Moreover, we identify rs37369 in AGXT2 as the genetic basis of hyper-β-aminoisobutyric aciduria...
  3. pmc A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection
    George Nicholson
    Department of Statistics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 7:e1002270. 2011
    ....
  4. doi Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure
    Ben Caplin
    Nitric Oxide Signalling Group, Medical Research Council Clinical Sciences Center, Imperial College London, London, United Kingdom
    Arterioscler Thromb Vasc Biol 32:2892-900. 2012
    ..We investigated the significance of AGXT2 in methylarginine metabolism in vivo and examined the effect of this enzyme on blood pressure...
  5. pmc A genome-wide association study of the human metabolome in a community-based cohort
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Metab 18:130-43. 2013
    ..Thus, our study outlines the relative contributions of inherited and clinical factors on the plasma metabolome and provides a resource for metabolism research. ..
  6. doi Missense variants of the alanine:glyoxylate aminotransferase 2 gene are not associated with Japanese schizophrenia patients
    Yuta Yoshino
    Department of Neuropsychiatry, Molecule Function, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 53:137-41. 2014
    ..We concluded that the AGXT2 gene is not associated with schizophrenia in Japanese subjects. ..
  7. doi Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes
    Maike Anderssohn
    Corresponding author Maike Anderssohn
    Diabetes Care 37:846-54. 2014
    ....
  8. ncbi Association of the AGXT2 V140I polymorphism with risk for coronary heart disease in a Chinese population
    Ji Peng Zhou
    Department of Clinical Pharmacology, Xiangya Hospital, Central South University
    J Atheroscler Thromb 21:1022-30. 2014
    ..This study was designed to explore the association of the AGXT2 V140I (rs37369 G>A) polymorphism with risk for coronary heart disease (CHD) in a Chinese population...
  9. pmc Modulation of renin angiotensin system predominantly alters sclerotic phenotype of glomeruli in HIVAN
    Andrei Plagov
    Renal Molecular Research Laboratory, Feinstein Institute for Medical Research, Manhasset, NY, USA
    Histol Histopathol 29:1575-81. 2014
    ..a genetically engineered mouse model of HIVAN (Tg26) with two and four copies of angiotensinogen (Agt) gene (Tg26/Agt2 and Tg26/Agt4)...
  10. doi Role of alanine:glyoxylate aminotransferase 2 in metabolism of asymmetric dimethylarginine in the settings of asymmetric dimethylarginine overload and bilateral nephrectomy
    Roman N Rodionov
    University Center for Vascular Medicine, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Nephrol Dial Transplant 29:2035-42. 2014
    ..The goal of our study was to test the hypothesis that AGXT2 is compensatory upregulated in the settings of ADMA overload and bilateral nephrectomy...
  11. pmc AGXT2: a promiscuous aminotransferase
    Roman N Rodionov
    University Center for Vascular Medicine and Department of Internal Medicine, Division of Angiology, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse 42, 01307 Dresden, Germany
    Trends Pharmacol Sci 35:575-82. 2014
    ..This article reviews the biochemical properties and physiological functions of AGXT2, its unique role at the intersection of key mitochondrial pathways, and its potential as a drug target. ..
  12. ncbi Missense variants of the alanine: glyoxylate aminotransferase 2 gene correlated with carotid atherosclerosis in the Japanese population
    Y Yoshino
    Department of Neuropsychiatry, Molecule and Function, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    Int J Immunopathol Pharmacol 28:605-14. 2014
    ..005) after correction. There was a significant correlation between the functional variants in the AGXT2 gene and carotid IMT in Japanese. The AGXT2 genotype may be an important factor underlying atherosclerosis. ..
  13. ncbi Missense variants of the alanine: glyoxylate aminotransferase 2 gene correlated with carotid atherosclerosis in the Japanese population
    Y Yoshino
    Department of Neuropsychiatry, Molecule and Function, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    J Biol Regul Homeost Agents 28:605-14. 2014
    ..02) and maximum IMT (P=0.005) after correction. There was a significant correlation between the functional variants in the AGXT2 gene and carotid IMT in Japanese. The AGXT2 genotype may be an important factor underlying atherosclerosis...
  14. doi Asymmetric dimethylarginine is transported by the mitochondrial carrier SLC25A2
    Vito Porcelli
    Laboratory of Biochemistry and Molecular Biology, Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona 4, 70125, Bari, Italy
    Amino Acids 48:427-36. 2016
    ..There is evidence that ADMA can also be imported into mitochondria, e.g., in kidney proximal tubulus cells, to be metabolized by AGXT2. SLC25A2 may also mediate this transport function. ..
  15. pmc Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke
    Ilkka Seppälä
    Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland
    Sci Rep 6:23207. 2016
    ..In conclusion, AGXT2 variations may be involved in the pathogenesis of AF and its age-related thromboembolic complications. ..
  16. doi Considerable impacts of AGXT2 V140I polymorphism on chronic heart failure in the Chinese population
    Xiao Lei Hu
    Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, China Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Changsha, 410078, China
    Atherosclerosis 251:255-62. 2016
    ..The aim of this study was to determine whether the AGXT2 rs37369 (V140I) polymorphism is associated with risk for and prognosis of CHF in Chinese patients...
  17. pmc A Novel Pathway for Metabolism of the Cardiovascular Risk Factor Homoarginine by alanine:glyoxylate aminotransferase 2
    Roman N Rodionov
    University Center for Vascular Medicine, Technische Universitat Dresden, Fetscherstraße 74, 01307 Dresden, Germany
    Sci Rep 6:35277. 2016
    ..Our findings may lead to development of novel therapeutic approaches for cardiovascular pathologies associated with homoarginine deficiency...
  18. pmc Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2
    Dmitry V Burdin
    Department of Physiology, Saint Petersburg State University, 199034 Saint Petersburg, Russia
    Sci Rep 6:35503. 2016
    ....
  19. pmc Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and β-aminoisobutyrate metabolism in healthy volunteers
    Anja Kittel
    Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 9:e88544. 2014
    ..In conclusion, SNPs of AGXT2 affect plasma as well as urinary BAIB and SDMA concentrations linking methylarginine metabolism to the common genetic trait of hyper-β-aminoisobutyric aciduria...
  20. pmc Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links
    Rico Rueedi
    Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland
    PLoS Genet 10:e1004132. 2014
    ..The replication of previous associations and our new discoveries demonstrate the potential of untargeted metabolomics GWAS to robustly identify molecular disease markers. ..
  21. ncbi Pharmacology and clinical pharmacology of methylarginines used as inhibitors of nitric oxide synthases
    Anja Kittel
    Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander Universitat Erlangen Nurnberg, Fahrstraße 17, 91054 Erlangen, Germany
    Curr Pharm Des 20:3530-47. 2014
    ....
  22. doi Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality
    Ilkka Seppälä
    Department of Clinical Chemistry, Fimlab Laboratories, Tampere University School of Medicine, Finn Medi 2, 3rd Floor, PO Box 2000, Tampere FI 33521, Finland
    Eur Heart J 35:524-31. 2014
    ....
  23. doi Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets?
    Luc Rochette
    Laboratoire de Physiopathologie et Pharmacologies Cardio Métaboliques LPPCM, France Electronic address
    Pharmacol Ther 140:239-57. 2013
    ..Therefore, it appears that both a lack and excess of NO production in diseases can have various important pathological implications. In this context, NOS modulators (exogenous and endogenous) and their therapeutic effects are discussed...
  24. doi Probing AGXT2 enzyme activity in mouse tissue by applying stable isotope-labeled asymmetric dimethyl arginine as substrate
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Leipziger Str 44, 39120, Magdeburg, Germany
    J Mass Spectrom 47:1594-600. 2012
    ..21 pmol/min/mg total protein in kidney tissue, with coefficients of variation of 6.31% and 11.25%, respectively. This method can be applied as a tool for the characterization of the ADMA elimination by the AGXT2 pathway...
  25. doi In vivo evidence that Agxt2 can regulate plasma levels of dimethylarginines in mice
    Anja Kittel
    Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander Universitat Erlangen Nurnberg, Fahrstraße 17, 91054 Erlangen, Germany
    Biochem Biophys Res Commun 430:84-9. 2013
    ..The effect of BAIB excess on endogenous dimethylarginine levels may have direct clinical implications for humans with the relatively common genetic trait of hyper-β-aminoisobutyric aciduria...
  26. ncbi Molecular cloning and sequencing of a cDNA encoding alanine-glyoxylate aminotransferase 2 from rat kidney
    I S Lee
    Department of Biochemistry, Wakayama Medical College
    J Biochem 117:856-62. 1995
    ..The amino acid sequences of nine tryptic and seven CNBr peptides of the rat kidney AGT2 were determined...
  27. doi Detection and quantification of α-keto-δ-(N(G),N(G)-dimethylguanidino)valeric acid: a metabolite of asymmetric dimethylarginine
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, 39120 Magdeburg, Germany
    Anal Biochem 419:234-40. 2011
    ..1 and 77.5 nmol/L. In urine samples, concentrations between 0.0114 and 1.03 μmol/mmol creatinine were found. This method can be used as a tool for the scientific investigation of the ADMA conversion to DMGV via the enzyme AGXT2...
  28. ncbi One-pot synthesis of amino-alcohols using a de-novo transketolase and beta-alanine: pyruvate transaminase pathway in Escherichia coli
    C U Ingram
    Department of Biochemical Engineering, University College London, London, WC1E 7JW, United Kingdom
    Biotechnol Bioeng 96:559-69. 2007
    ..ABT synthesis was achieved in a one-pot process, using either whole cells of the dual plasmid strain or cell lysate, while the dual alcohol-amine functionality of ABT makes it an excellent synthon for many pharmaceutical syntheses...
  29. ncbi Primary hyperoxaluria: from gene defects to designer drugs?
    Christopher J Danpure
    Nephrol Dial Transplant 20:1525-9. 2005
  30. ncbi Glycolate and glyoxylate metabolism in HepG2 cells
    Paul R S Baker
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Physiol Cell Physiol 287:C1359-65. 2004
    ..Expression of AGT2 mRNA in HepG2 cells was confirmed by RT-PCR...
  31. pmc Alanine aminotransferase homologs catalyze the glutamate:glyoxylate aminotransferase reaction in peroxisomes of Arabidopsis
    Aaron H Liepman
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    Plant Physiol 131:215-27. 2003
    ..Three Arabidopsis homologs of alanine (Ala):glyoxylate aminotransferase 2 (AGT2) contain a putative type 1 peroxisomal targeting signal (PTS1), but the metabolic significance of these AGT2 ..