AGTR1

Summary

Gene Symbol: AGTR1
Description: angiotensin II receptor type 1
Alias: AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R, type-1 angiotensin II receptor, type-1B angiotensin II receptor
Species: human

Top Publications

  1. doi Devil and angel in the renin-angiotensin system: ACE-angiotensin II-AT1 receptor axis vs. ACE2-angiotensin-(1-7)-Mas receptor axis
    Masaru Iwai
    Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Shitsukawa, Tohon, Ehime, Japan
    Hypertens Res 32:533-6. 2009
  2. ncbi MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts
    Mickey M Martin
    Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 281:18277-84. 2006
  3. ncbi Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptors
    Jurgen Janke
    Max Delbruck Center for Molecular Medicine, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Diabetes 51:1699-707. 2002
  4. ncbi A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated so
    Arne Heydorn
    Laboratory for Molecular Pharmacology, Department of Pharmacology, Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    J Biol Chem 279:54291-303. 2004
  5. ncbi The increased angiotensin II (type 1) receptor density in myocardium of type 2 diabetic patients is prevented by blockade of the renin-angiotensin system
    H Reuter
    Laboratory of Muscle Research and Molecular Cardiology, Department III of Internal Medicine, University of Cologne, Joseph Stelzmann Str 9, Cologne, Germany
    Diabetologia 49:3067-74. 2006
  6. ncbi Angiotensin II type 1 receptor expression in human gastric cancer and induces MMP2 and MMP9 expression in MKN-28 cells
    Wei Huang
    Department of Gastroenterology, Ruijin Hospital, Jiaotong University School of Medicine, Shanghai, China
    Dig Dis Sci 53:163-8. 2008
  7. ncbi Possible synergic effect of angiotensin-I converting enzyme gene insertion/deletion polymorphism and angiotensin-II type-1 receptor 1166A/C gene polymorphism on ischemic heart disease in patients with Kawasaki disease
    Ryuji Fukazawa
    Department of Pediatrics, Nippon Medical School, 113 8603 Tokyo, Japan
    Pediatr Res 56:597-601. 2004
  8. ncbi Angiotensin II type 1 and bradykinin B2 receptors expressed in early stage epithelial cells derived from human embryonic stem cells
    Zhenhua Huang
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Physiol 211:816-25. 2007
  9. ncbi Genetic polymorphisms of the angiotensin II type 1 receptor gene and diastolic heart failure
    Cho Kai Wu
    Department of Internal Medicine, National Taiwan University College of Medicine and Hospital Yun Lin Branch, Yun Lin, Taiwan
    J Hypertens 27:502-7. 2009
  10. doi Differential expression of angiotensin II type 1 and type 2 receptors at the maternal-fetal interface: potential roles in early placental development
    C L Tower
    Maternal and Fetal Health Research Group, Manchester Academic Health Science Centre, St Mary s Hospital, University of Manchester, Oxford Road, Manchester M13 9WL, UK
    Reproduction 140:931-42. 2010

Research Grants

  1. Role of the Renin-Angiotensin system in placental insufficiency
    Eugenia Mata-Greenwood; Fiscal Year: 2013
  2. Tahir Hussain; Fiscal Year: 2016
  3. Role of angiotensin II receptor signaling pathways in body fluid homeostasis
    Derek Daniels; Fiscal Year: 2013
  4. Pharmacologic Interventions for Cardiovascular Disease in Obstructive Sleep Apnea
    Barbara J Morgan; Fiscal Year: 2013
  5. Central Angiotensin receptors and teh neural control of homeostasis
    ERIC GERALD KRAUSE; Fiscal Year: 2013
  6. Mohammad Asghar; Fiscal Year: 2015
  7. 2010 Angiotensin Gordon Research Conference
    Kathy K Griendling; Fiscal Year: 2010
  8. Brain specific non-AT1, non-AT2 angiotensin binding site
    ROBERT CHARLES SPETH; Fiscal Year: 2010
  9. JAMES RUSSELL SOWERS; Fiscal Year: 2015
  10. AT1R-regulated nuclear functions of Gb2
    Sadashiva S Karnik; Fiscal Year: 2012

Detail Information

Publications326 found, 100 shown here

  1. doi Devil and angel in the renin-angiotensin system: ACE-angiotensin II-AT1 receptor axis vs. ACE2-angiotensin-(1-7)-Mas receptor axis
    Masaru Iwai
    Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Shitsukawa, Tohon, Ehime, Japan
    Hypertens Res 32:533-6. 2009
    ..However, this second axis through ACE2 and Ang-(1-7) in RAS can be an important target for the therapy of cardiovascular and metabolic disorders...
  2. ncbi MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts
    Mickey M Martin
    Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 281:18277-84. 2006
    ..Importantly, the translational repression mediated by miR-155 can be regulated by physiological stimuli...
  3. ncbi Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptors
    Jurgen Janke
    Max Delbruck Center for Molecular Medicine, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Diabetes 51:1699-707. 2002
    ..Because AGT secretion and Ang II generation are characteristic features of adipogenesis, we postulate a paracrine negative-feedback loop that inhibits further recruitment of preadipocytes by maturing adipocytes...
  4. ncbi A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated so
    Arne Heydorn
    Laboratory for Molecular Pharmacology, Department of Pharmacology, Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    J Biol Chem 279:54291-303. 2004
    ..It is concluded that the tail library provides useful information on the general importance of certain adaptor proteins, for example, in this case, ruling out EBP50 as being a broad spectrum-recycling adaptor...
  5. ncbi The increased angiotensin II (type 1) receptor density in myocardium of type 2 diabetic patients is prevented by blockade of the renin-angiotensin system
    H Reuter
    Laboratory of Muscle Research and Molecular Cardiology, Department III of Internal Medicine, University of Cologne, Joseph Stelzmann Str 9, Cologne, Germany
    Diabetologia 49:3067-74. 2006
    The angiotensin II (type 1) (AT1) receptor mediates many biological effects of the renin-angiotensin system (RAS), leading to remodelling of cardiac tissue...
  6. ncbi Angiotensin II type 1 receptor expression in human gastric cancer and induces MMP2 and MMP9 expression in MKN-28 cells
    Wei Huang
    Department of Gastroenterology, Ruijin Hospital, Jiaotong University School of Medicine, Shanghai, China
    Dig Dis Sci 53:163-8. 2008
    ..in the renin-angiotensin system, acts as a growth-promoting and angiogenic factor via angiotensin II receptor1 (AT1R)...
  7. ncbi Possible synergic effect of angiotensin-I converting enzyme gene insertion/deletion polymorphism and angiotensin-II type-1 receptor 1166A/C gene polymorphism on ischemic heart disease in patients with Kawasaki disease
    Ryuji Fukazawa
    Department of Pediatrics, Nippon Medical School, 113 8603 Tokyo, Japan
    Pediatr Res 56:597-601. 2004
    ACE I/D and AT1R 1166A/C polymorphisms are considered to comprise individual risk factors for the development of coronary disease...
  8. ncbi Angiotensin II type 1 and bradykinin B2 receptors expressed in early stage epithelial cells derived from human embryonic stem cells
    Zhenhua Huang
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Physiol 211:816-25. 2007
    ..However, transduction of the hES cells with lentivirus containing BKB2 or AT1R cDNA resulted in ligand binding and ERK1/2 activation but not in Galphai or Galphaq coupled signaling...
  9. ncbi Genetic polymorphisms of the angiotensin II type 1 receptor gene and diastolic heart failure
    Cho Kai Wu
    Department of Internal Medicine, National Taiwan University College of Medicine and Hospital Yun Lin Branch, Yun Lin, Taiwan
    J Hypertens 27:502-7. 2009
    The aim of the study was to investigate the association between angiotensin II type 1 receptor (AGTR1) gene polymorphisms and diastolic heart failure (DHF) in a case controlled study.
  10. doi Differential expression of angiotensin II type 1 and type 2 receptors at the maternal-fetal interface: potential roles in early placental development
    C L Tower
    Maternal and Fetal Health Research Group, Manchester Academic Health Science Centre, St Mary s Hospital, University of Manchester, Oxford Road, Manchester M13 9WL, UK
    Reproduction 140:931-42. 2010
    ..It acts through two receptor subtypes, AGTR1 and AGTR2 (AT1 and AT2), which typically mediate antagonising actions...
  11. pmc Angiotensin II type 1 receptor signalling regulates microRNA differentially in cardiac fibroblasts and myocytes
    Pia Lindgren Jeppesen
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark and Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
    Br J Pharmacol 164:394-404. 2011
    ..Since several microRNAs (miRNAs) have been implicated in cardiac disease, we determined whether miRNAs might be regulated by AT(1)R signals in a Gαq/11-dependent or -independent manner...
  12. pmc Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degeneration
    Marianne Pons
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA
    Am J Pathol 178:2665-81. 2011
    ..A better understanding of the molecular events by which Ang II induces ECM dysregulation is of critical importance to further define its contribution to the progression of sub-RPE deposits in AMD patients with HTN...
  13. pmc Angiotensin receptor type 1 single nucleotide polymorphism 1166A/C is associated with malignant arrhythmias and altered circulating miR-155 levels in patients with chronic heart failure
    Raul R Blanco
    Emory University School of Medicine, Atlanta, GA, USA
    J Card Fail 18:717-23. 2012
    ..Prediction of which HF patients are most susceptible to SCD is difficult, and it is uncertain whether gene polymorphisms associated with HF outcomes are also linked to arrhythmic risk...
  14. ncbi Angiotensin II type 1 receptor blockade inhibits the development and progression of HIV-associated nephropathy in a mouse model
    Noriyuki Hiramatsu
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
    J Am Soc Nephrol 18:515-27. 2007
    ..subsequent glomerulosclerosis by heminephrectomy was almost completely inhibited by angiotensin II type 1 receptor (AT1R) blocker olmesartan...
  15. pmc Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population
    J A Schoenhard
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
    Hum Genet 124:479-88. 2008
    ....
  16. ncbi Angiotensin II type 1 receptor expression on human leukocyte subsets: a flow cytometric and RT-PCR study
    Emanuela Rasini
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    Regul Pept 134:69-74. 2006
    ..plays a key role in the regulation of cardiovascular functions and in particular angiotensin II type 1 receptor (AT1R)-operated pathways are involved in the modulation of inflammation in the vascular wall...
  17. ncbi Role of helix 8 in G protein-coupled receptors based on structure-function studies on the type 1 angiotensin receptor
    John Huynh
    School of Biomedical Sciences, The University of Queensland, Brisbane, St Lucia, Queensland, Australia
    Mol Cell Endocrinol 302:118-27. 2009
    ..The type 1 angiotensin II receptor is a widely studied GPCR with roles in blood pressure regulation,water and salt balance and cell ..
  18. ncbi Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor
    H Furuta
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232
    Biochem Biophys Res Commun 183:8-13. 1992
    The gene of human angiotensin II type 1 (AT1) receptor was isolated from a lymphocyte genomic library...
  19. ncbi Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms
    K M Curnow
    Institute National de la Santé et de la Recherche Médicale U36, Chaire de Médicine Expérimentale Collège de France, Paris
    Mol Endocrinol 9:1250-62. 1995
    ..protein (G protein)-coupled receptor pharmacologically defined as the type-1 AngII receptor or AT1. Characterization of cDNA and genomic clones shows that the human AT1 gene contains five exons and encodes two ..
  20. ncbi Essential role of leucine222 in mediating signal transduction of the human angiotensin II type 1 receptor
    S A Laporte
    Department of Pharmacology, Faculty of Medicine, Universite de Sherbrooke, Quebec, Canada
    Receptors Channels 5:103-12. 1998
    The angiotensin II (Ang II) type I receptor (AT1) is a member of the superfamily of heptahelical, G protein-coupled receptors (GPCRs) characterized by hydrophobic transmembrane domains connected by extra- and intracellular hydrophilic ..
  21. ncbi Residues 293 and 294 are ligand contact points of the human angiotensin type 1 receptor
    Jacqueline Pérodin
    Departement de Pharmacologie, Faculte de Medecine, Universite de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, Quebec, J1H 5N4, Canada
    Biochemistry 41:14348-56. 2002
    ..A., Wilkes, B. C., Laporte, S. A., Escher, E., Guillemette, G., and Leduc, R. (2000) Biochemistry 39, 9662-70) the Ang II molecule must adopt an extended structure in the AngII binding pocket...
  22. ncbi A1166C angiotensin II type 1 receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal hypertension
    Silvia Sookoian
    Cardiologia Molecular, Instituto de Investigaciones Medicas A Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina
    Am J Gastroenterol 100:636-42. 2005
    ..relationship between genetic polymorphisms of the renin-angiotensin system (A1166C angiotensin II type 1 receptor (AT1R), angiotensinogen T174M and M235T, and angiotensin-converting enzyme I/D) and the effects of losartan on portal and ..
  23. ncbi Modulation by bradykinin of angiotensin type 1 receptor-evoked RhoA activation of connective tissue growth factor expression in human lung fibroblasts
    Zhenhua Huang
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1291-9. 2006
    ..An inducible expression system is used to insert AngII receptor 1 (AT1R) and to obtain a signal level in response to AngII at the magnitude of BK...
  24. ncbi Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans
    Ivonne Hernandez Schulman
    Hypertension 49:270-1. 2007
  25. doi Differential D1 and D5 receptor regulation and degradation of the angiotensin type 1 receptor
    John J Gildea
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Hypertension 51:360-6. 2008
    ..The discovery of differential regulation by D(1)R and D(5)R opens new avenues for the development of agonists selective to either receptor subtype as targeted antihypertensive agents that can decrease AT(1)R-mediated antinatriuresis...
  26. pmc Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation
    Noritaka Yasuda
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    EMBO Rep 9:179-86. 2008
    ..Our results show that the AT(1) receptor undergoes a conformational switch that couples mechanical stress-induced activation and inverse agonist-induced inactivation...
  27. doi Cardiac-specific overexpression of the human type 1 angiotensin II receptor causes delayed repolarization
    Katy Rivard
    Research Centre, Montreal Heart Institute, 5000 rue Belanger, Montreal, QC, Canada H1T 1C8
    Cardiovasc Res 78:53-62. 2008
    Mice with cardiac-specific overexpression of human angiotensin II type 1 receptor (AT1R) undergo cardiac remodelling and die prematurely of sudden death...
  28. doi NADPH oxidase 1 deficiency alters caveolin phosphorylation and angiotensin II-receptor localization in vascular smooth muscle
    Olivier Basset
    Department of Pathology and Immunology, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
    Antioxid Redox Signal 11:2371-84. 2009
    The superoxide-generating NADPH oxidase NOX1 is thought to be involved in signaling by the angiotensin II-receptor AT1R. However, underlying signaling steps are poorly understood...
  29. doi Angiotensin type 1 receptor expression and interleukin-8 production in polymorphonuclear leukocytes of patients with peripheral arterial disease
    Franca Marino
    Department of Clinical Medicine, Section of Experimental and Clinical Pharmacology, University of Insubria, Varese VA, Italy
    J Cardiovasc Pharmacol 54:520-5. 2009
    We investigated angiotensin type 1 receptor (AT1R) expression and interleukin-8 (IL-8) productions in polymorphonuclear leukocytes obtained from patients with peripheral arterial disease (PAD) undergoing femoral endarterectomy...
  30. doi Angiotensin II receptor type 1 is upregulated in atrial tissue of patients with rheumatic valvular disease with atrial fibrillation
    Hongliang Cong
    Department of Cardiology, Tianjin Chest Hospital, Tianjin, China
    J Thorac Cardiovasc Surg 140:298-304. 2010
    ..The purpose of this study was to examine the changes in expression of angiotensin II receptor type 1/2 in left or right atrial tissue from patients with rheumatic valvular disease with or without atrial fibrillation...
  31. pmc Cross-talk between angiotensin II and IGF-1-induced connexin 43 expression in human saphenous vein smooth muscle cells
    Guanghong Jia
    Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, USA
    J Cell Mol Med 15:1695-702. 2011
    ..These data demonstrate a cross-talk between IGF-1R and AT-1R in AT-II and IGF-1-induced Cx43 expression in SV SMCs involving Erk 1/2 and downstream activation of the AP-1 transcription factor...
  32. doi Association between angiotensin II type 1 receptor gene polymorphisms and ischemic stroke: a meta-analysis
    Hao Zhang
    Department of Neurosurgery, the Affiliated Hospital of Medical College, Ningxia Medical University, Yinchuan, PR China
    Cerebrovasc Dis 32:431-8. 2011
    Angiotensin II type 1 receptor (AT1R) gene A1166C polymorphisms have been inconsistently associated with ischemic stroke risk. We examined these associations by performing a meta-analysis.
  33. pmc Mapping of the localization of type 1 angiotensin receptor in membrane microdomains using bioluminescence resonance energy transfer-based sensors
    Andras Balla
    Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    J Biol Chem 287:9090-9. 2012
    ....
  34. doi Meta-analysis of the association between angiotensin II receptor, type 1 gene A1166C polymorphism and coronary artery disease in Chinese populations
    Yuqiong Li
    State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai, China
    J Renin Angiotensin Aldosterone Syst 14:82-90. 2013
    and objective: Many studies have examined the association between the angiotensin II receptor, type 1 (AGTR1) gene A1166C polymorphism and coronary artery disease (CAD); the results, however, remain controversial...
  35. doi Association of polymorphisms in angiotensin-converting enzyme and type 1 angiotensin II receptor genes with coronary heart disease and the severity of coronary artery stenosis
    Chunguang Qiu
    Department of Cardiology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China
    J Huazhong Univ Sci Technolog Med Sci 27:660-3. 2007
    To explore the relation of angiotensin-converting enzyme (ACE) and angiotensin II type 1 receptor (AT1R) gene polymorphism with coronary heart disease (CHD) and the severity of coronary artery stenosis, 130 CHD patients who underwent ..
  36. pmc Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease
    Ivan Dimitrijevic
    Department of Medicine, Lund University Hospital, Lund, Sweden
    BMC Cardiovasc Disord 9:40. 2009
    ..The aim of the present study was to examine the endothelin and angiotensin II receptor expression in subcutaneous arteries from patients with different degrees of ischemic heart disease...
  37. doi Increased expression of endothelin ET(B) and angiotensin AT(1) receptors in peripheral resistance arteries of patients with suspected acute coronary syndrome
    Ivan Dimitrijevic
    Divisions of Emergency Medicine and Experimental Vascular Research, Department of Clinical Sciences, Lund University Hospital, BMC A13, SE 221 84 Lund, Sweden
    Heart Vessels 24:393-8. 2009
    ..These receptor changes could be important in the regulation of coronary tone and in the development of atherosclerosis, and may be related to increased cardiovascular risk...
  38. doi Blocking angiotensin II Type 1 receptor triggers apoptotic cell death in human pancreatic cancer cells
    Qiaoke Gong
    Department of Surgery, Jefferson Pancreatic, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Pancreas 39:581-94. 2010
    ..We recently demonstrated that angiotensin II (AngII) type 1 receptor (AT1R) might be involved in PDA angiogenesis...
  39. doi Association of angiotensin I converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms with breast cancer prognostic factors in Iranian population
    Soha Namazi
    Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
    Mol Carcinog 49:1022-30. 2010
    ..is one of angiotensin I converting enzyme (ACE) polymorphisms and A1166C is one of angiotensin II type-1 receptor (AT1R) polymorphisms which have been associated with various diseases such as cardiovascular diseases...
  40. doi Non-activated APJ suppresses the angiotensin II type 1 receptor, whereas apelin-activated APJ acts conversely
    Xiao Sun
    Department of Cardiovascular Surgery, Saitama Medical Center, Saitama, Japan
    Hypertens Res 34:701-6. 2011
    ..These results may be relevant to the potential contribution of apelin-APJ to ARB treatment in the clinical realm...
  41. pmc Angiotensin II type 1 receptor signaling regulates feeding behavior through anorexigenic corticotropin-releasing hormone in hypothalamus
    Rie Yamamoto
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Chiba 260 8670, Japan
    J Biol Chem 286:21458-65. 2011
    ....
  42. ncbi Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor
    R Takayanagi
    Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 183:910-6. 1992
    ..The expression of the Ang II receptor mRNA was detected in human liver, lung, adrenal and adrenocortical adenomas but not in adrenomedullary tumor, pheochromocytoma, by Northern blot analysis...
  43. ncbi A1166C variant of angiotensin II type 1 receptor gene is associated with severe hypertension in pregnancy independently of T235 variant of angiotensinogen gene
    Gen Kobashi
    Division of Preventive Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Sapporo 060 8638, Japan
    J Hum Genet 49:182-6. 2004
    ..aim of this study was to assess the association between the A1166C variant of the angiotensin II type 1 receptor (AT1) gene and severe HP...
  44. ncbi Polymorphisms in angiotensin II type 1 receptor and angiotensin I-converting enzyme genes and breast cancer risk among Chinese women in Singapore
    Woon Puay Koh
    Department of Community, Occupational and Family Medicine, National University of Singapore, 16 Medical Drive, Singapore 117597, Singapore
    Carcinogenesis 26:459-64. 2005
    ..mediate growth in breast cancer cell lines via ligand-induced activity through the angiotensin II type 1 receptor (AGTR1)...
  45. ncbi No association between variants in the ACE and angiotensin II receptor 1 genes and acute mountain sickness in Nepalese pilgrims to the Janai Purnima Festival at 4380 m
    Michael S Koehle
    Allan McGavin Sport Medicine Centre, Department of Family Practice, University of British Columbia, Vancouver, Canada
    High Alt Med Biol 7:281-9. 2006
    ..loci in the genes encoding angiotensin converting enzyme (ACE) and angiotensin II receptor type 1 gene (AGTR1)...
  46. pmc Angiotensin II type 1 receptor 1166C polymorphism is associated with abdominal aortic aneurysm in three independent cohorts
    Gregory T Jones
    Department of Surgery, University of Otago, New Zealand
    Arterioscler Thromb Vasc Biol 28:764-70. 2008
    ..This study was undertaken, using the largest case series yet reported, to determine whether common genetic variants of the RAS are associated with either susceptibility or severity of AAA...
  47. doi Genetic variation and activity of the renin-angiotensin system and severe hypoglycemia in type 1 diabetes
    Ulrik Pedersen-Bjergaard
    Endocrinology Section, Division of Internal Medicine I, Hillerød Hospital, Hillerød, Denmark
    Am J Med 121:246.e1-8. 2008
    ..We explored whether genetic and phenotypic variations in other components of the renin-angiotensin system are similarly associated...
  48. pmc Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension
    Wendy K Chung
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Heart Lung Transplant 28:373-9. 2009
    ..The renin angiotensin aldosterone system (RAAS) provides a set of candidate genes that could modulate pulmonary vascular disease similar to its effects on renal and peripheral vasculature...
  49. doi Adenine/cytosine(1166) polymorphism of the angiotensin II type 1 receptor gene and the antihypertensive response to angiotensin-converting enzyme inhibitors
    Huimin Yu
    Department of Cardiology, Guangdong General Hospital and Guangdong Cardiovascular Institute, Guangzhou, China
    J Hypertens 27:2278-82. 2009
    ..Thus, it may have the potential to predict the blood pressure response of patients with hypertension to angiotensin-converting enzyme inhibitors (ACEIs)...
  50. doi Angiotensin-converting enzyme insertion/deletion and angiotensin type 1 receptor A1166C polymorphisms as genetic risk factors in benign prostatic hyperplasia and prostate cancer
    Erick Sierra Díaz
    Hospital de Especialidades, Centro Medico Nacional de Occidente, Instituto Mexicano del Seguro Social, Mexico
    J Renin Angiotensin Aldosterone Syst 10:241-6. 2009
    ....
  51. pmc miR-802 regulates human angiotensin II type 1 receptor expression in intestinal epithelial C2BBe1 cells
    Sarah E Sansom
    Davis Heart and Lung Research Institute, Department of Pathology, The Ohio State Univ, Columbus, 43210, USA
    Am J Physiol Gastrointest Liver Physiol 299:G632-42. 2010
    ..These results suggest that miR-802 can modulate the expression of the hAT(1)R in the GI tract and ultimately play a role in regulating the biological efficacy of Ang II in this system...
  52. doi Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy
    Fabrice Jaffré
    Institut National de Santé et de Recherche Médicale, U839, Paris, France
    Circ Res 104:113-23. 2009
    ..Accordingly, antagonists of 5-HT(2B) receptors might represent novel therapeutics for sympathetic overstimulation-dependent heart failure...
  53. pmc The second transmembrane domain of the human type 1 angiotensin II receptor participates in the formation of the ligand binding pocket and undergoes integral pivoting movement during the process of receptor activation
    Ivana Domazet
    Department of Pharmacology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 284:11922-9. 2009
    ..Our results suggest that constitutive activation of the AT(1) receptor causes TMD2 to pivot, bringing the top of TMD2 closer to the binding pocket and pushing the bottom of TMD2 away from the binding pocket...
  54. doi Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women
    Silvana Aparecida Alves Correa
    Molecular Gynaecology Laboratory, Department of Gynaecology, Federal University of Sao Paulo, Rua Pedro de Toledo, 781 4th Floor, Sao Paulo, 04039 032 SP, Brazil
    J Renin Angiotensin Aldosterone Syst 10:51-8. 2009
    ....
  55. ncbi Distribution of type-1 and type-2 angiotensin receptors in the normal human lung and in lungs from patients with chronic obstructive pulmonary disease
    G R Bullock
    Department of Pathology, Blok A 503, University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Histochem Cell Biol 115:117-24. 2001
    This study was designed to examine the cellular distribution of the angiotensin II type-1 (AT1) and type-2 (AT2) receptors in the normal human and pathological human lung...
  56. ncbi A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling
    Patrice C Leclerc
    Department of Pharmacology, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Endocrinology 143:4702-10. 2002
    ....
  57. ncbi Left ventricular size, mass and function in relation to angiotensin-converting enzyme gene and angiotensin-II type 1 receptor gene polymorphisms in patients with coronary artery disease
    Marcin Gruchala
    First Department of Cardiology Medical University of Gdansk, Gdansk, Poland
    Clin Chem Lab Med 41:522-8. 2003
    ..enzyme gene (I/D ACE) and the A1166C polymorphism of the angiotensin-II type 1 receptor gene polymorphisms (A1166C AT1R) on the left ventricular size and performance...
  58. ncbi Translation of the human angiotensin II type 1 receptor mRNA is mediated by a highly efficient internal ribosome entry site
    Mickey M Martin
    Department of Chemistry and Biochemistry, Brigham Young University, C211 BNSN, P O Box 25700, Provo, UT 84602 5700, USA
    Mol Cell Endocrinol 212:51-61. 2003
    ..The human AT1R (hAT1R) mRNA splice variants have long 5'-untranslated regions (5'-UTRs) ranging from 272 to 414 bp that have the ..
  59. ncbi Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors
    Yasushi Kawaguchi
    Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Arthritis Rheum 50:216-26. 2004
    ....
  60. ncbi Ischemic heart disease down-regulates angiotensin type 1 receptor mRNA in human coronary arteries
    Angelica Wackenfors
    Department of Internal Medicine, Division of Experimental Vascular Research, Lund University Hospital, BMC A13, SE 221 84 Lund, Sweden
    Eur J Pharmacol 503:147-53. 2004
    ..The angiotensin type 1 (AT1) receptor mRNA levels were down-regulated in human coronary arteries from patients with ischemic heart disease as ..
  61. ncbi Polymorphisms of the angiotensin converting enzyme and angiotensin II type 1 receptor genes and renal scarring in non-uropathic children with recurrent urinary tract infection
    Aydin Ece
    Department of Pediatrics, Pediatric Nephrology Unit, Dicie University, Diyarbakir, Turkey
    Nephrology (Carlton) 10:377-81. 2005
    ....
  62. pmc Angiotensin II type 1 receptor expression in ovarian cancer and its correlation with tumour angiogenesis and patient survival
    K Ino
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Br J Cancer 94:552-60. 2006
    ..that angiotensin II enhanced tumour cell invasion and vascular endothelial growth factor (VEGF) secretion via AT1R in ovarian cancer cell lines in vitro...
  63. ncbi TGF-beta(1) regulation of human AT(1) receptor mRNA splice variants harboring exon 2
    Mickey M Martin
    College of Pharmacy, Division of Pharmacology, The Ohio State University, Columbus, OH 43210, USA
    Mol Cell Endocrinol 249:21-31. 2006
    ....
  64. ncbi Angiotensin type-1 receptor A1166C gene polymorphism correlates with oxidative stress levels in human heart failure
    Vicky A Cameron
    Cardioendocrine Research Group, Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Hypertension 47:1155-61. 2006
    ..Studies in vascular cells and experimental animals have demonstrated that the angiotensin type-1 receptor (AT1R) contributes to formation of reactive oxygen species by activating nicotinamide-adenine dinucleotide phosphate ..
  65. ncbi Recurrent in-stent restenosis is not associated with the angiotensin-converting enzyme D/I, angiotensinogen Thr174Met and Met235Thr, and the angiotensin-II receptor 1 A1166C polymorphism
    C Michael Gross
    Franz Volhard Klinik, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Invasive Cardiol 19:261-4. 2007
    ..enzyme (ACE) D/I, the angiotensinogen (AGT) T174M and M235T, and A1166C of the angiotensin-II receptor 1 (AGTR1), revealed that the incidence RISR in the high-risk cohort was not associated with any of the polymorphisms ..
  66. ncbi ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin
    Marie Eve Poupart
    Department of Pharmacology, School of Medicine, University of Montreal, Montreal, QC, Canada
    Cell Signal 19:2370-8. 2007
    ..Taken together, these results suggest that the cycling of ARF6 between its GDP-and GTP-bound states coordinates the recruitment of AP-2 and clathrin to activated receptors during the endocytic process...
  67. ncbi Angiotensin II induces vascular endothelial growth factor in pancreatic cancer cells through an angiotensin II type 1 receptor and ERK1/2 signaling
    Rathai Anandanadesan
    Department of Surgery, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA, USA
    J Gastrointest Surg 12:57-66. 2008
    ..We have recently shown that high levels of angiotensin II (AngII) type 1 receptor (AT1R) correlate and colocalize with VEGF in invasive PDA and that AngII induces VEGF expression in PDA cell lines...
  68. ncbi Telmisartan inhibits CD4-positive lymphocyte migration independent of the angiotensin type 1 receptor via peroxisome proliferator-activated receptor-gamma
    Daniel Walcher
    Department of Internal Medicine II Cardiology, University of Ulm, Robert Koch Str 8, D 89081 Ulm, Germany
    Hypertension 51:259-66. 2008
    ..Telmisartan is an angiotensin type 1 receptor (AT1R) blocker with peroxisome proliferator-activated receptor (PPAR)-gamma-activating properties...
  69. doi Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus
    Patricia H Gallego
    Department of Pediatric Endocrinology and Diabetes, Princess Margaret Hospital, Perth, WA, Australia
    J Diabetes Complications 22:191-8. 2008
    ..enzyme (ACE) insertion/deletion (I/D) for angiotensinogen (AGT) M235T and angiotensin II receptor type 1 (AGTR1) A1166C as predictors for the development of microalbuminuria (MA) in children with type 1 diabetes mellitus (T1DM)...
  70. pmc Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds
    L M Luttrell
    The Geriatrics Research, Education and Clinical Center, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA
    Proc Natl Acad Sci U S A 98:2449-54. 2001
    ..of extracellular signal-regulated kinase 2 (ERK2) following stimulation of angiotensin II type 1a receptors (AT1aR)...
  71. ncbi Molecular basis of salt sensitivity in human hypertension. Evaluation of renin-angiotensin-aldosterone system gene polymorphisms
    E Poch
    Nephrology Department, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    Hypertension 38:1204-9. 2001
    ..The BP response to high salt intake was different among genotypes of ACE I/D and 11betaHSD G534A, suggesting that these polymorphisms may be potentially useful genetic markers of salt sensitivity...
  72. pmc Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
    Genevieve Nguyen
    Institut National de la Santé et de la Recherche Médicale INSERM U489, and Association Claude Bernard, Hopital Tenon, Paris, France
    J Clin Invest 109:1417-27. 2002
    ..This discovery emphasizes the role of the cell surface in angiotensin II generation and opens new perspectives on the tissue renin-angiotensin system and on renin effects independent of angiotensin II...
  73. ncbi Genetic effects versus bias for candidate polymorphisms in myocardial infarction: case study and overview of large-scale evidence
    Evangelia E Ntzani
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Epidemiol 165:973-84. 2007
    ..In a meta-analysis of 27 studies addressing the association of the angiotensin type 1 receptor (AT1R)+1166A/C polymorphism with MI (10,180 cases, 17,129 controls), the *C allele conferred an increase in MI risk (odds ..
  74. doi Genetic polymorphisms in the renin-angiotensin system confer increased risk of stroke independently of blood pressure: a nested case-control study
    Anna Möllsten
    Department of Clinical Sciences, Umea University, Sweden
    J Hypertens 26:1367-72. 2008
    ..Polymorphisms in involved genes have been described and implicated in stroke. The aim of this study was to investigate two polymorphisms in two genes in the renin-angiotensin system and the risk of stroke...
  75. pmc Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: a HuGE review
    Amy K Mottl
    Division of Nephrology and Hypertension, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Genet Med 10:560-74. 2008
    The angiotensin II type 1 receptor (AGTR1) plays an integral role in blood pressure control, and is implicated in the pathogenesis of hypertension...
  76. doi Angiotensin II type 1 receptor gene polymorphism and telomere shortening in essential hypertension
    Wael Farrag
    Department of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt
    Mol Cell Biochem 351:13-8. 2011
    ..Further strategies for treating high-risk patients could result in prevention or delay of end organ damage...
  77. ncbi Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor
    M B Marrero
    Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
    Nature 375:247-50. 1995
    ..and adrenal aldosterone release, are mediated through a single class of cell-surface receptors known as AT1 (refs 1, 2). These receptors contain the structural features of the G-protein-coupled receptor superfamily...
  78. ncbi Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension
    A Bonnardeaux
    INSERM U36, College de France, Paris
    Hypertension 24:63-9. 1994
    We conducted the present study to determine whether the angiotensin II type I receptor (AT1) gene might be implicated in human essential hypertension by using case-control and linkage studies...
  79. ncbi The genomic organization of human angiotensin II type 1 receptor
    D F Guo
    Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232
    Biochem Biophys Res Commun 200:313-9. 1994
    ..step toward the elucidation of human Ang II type 1 receptor gene expression, the genomic organization of the human AT1 receptor was investigated...
  80. ncbi Angiotensin receptors in the nervous system
    A M Allen
    The Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    Brain Res Bull 47:17-28. 1998
    ..Angiotensin AT1 and AT2 receptors occur in characteristic distributions that are highly correlated with the distribution of ..
  81. ncbi Effect of ACE gene polymorphism on age at renal death in polycystic kidney disease in Japan
    T Konoshita
    Third Department of Internal Medicine, Fukui Medical University, Fukui, Japan
    Am J Kidney Dis 37:113-118. 2001
    ..ie, ACE insertion/deletion (I/D) polymorphism, angiotensinogen (AGT) M235T, and angiotensin II type 1 receptor (AT1) A1166C. Seventy-six of the 103 patients (73.8%) reached ESRD at an average age of 52.1 +/- 11.3 years...
  82. ncbi Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*
    R H Oakley
    Howard Hughes Medical Institute Laboratories, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:19452-60. 2001
    ....
  83. ncbi [Association between angiotensin system gene polymorphism and essential hypertension]
    X Li
    Department of Cardiology, Gulou Hospital, School of Medicine of Nanjing University, Nanjing 210008 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 18:292-5. 2001
    ..To investigate whether angiotensinogen(AGT) M235T, angiotensin II type I receptor(AT(1)R) gene A1166C and angiotensin converting enzyme(ACE) gene I/D polymorphism are implicated in human essential hypertension(HT) in Chinese...
  84. ncbi Association of angiotensin II type 1 receptor gene polymorphism with essential hypertension
    Z Jiang
    Department of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China
    Chin Med J (Engl) 114:1249-51. 2001
    To determine whether the polymorphism A1166C in the angiotensin II type 1 receptor (AT1R) gene is associated with essential hypertension.
  85. ncbi Relationship between polymorphisms in the renin-angiotensin system and nephropathy in type 2 diabetic patients
    S Fradin
    Biochemistry, CHU Cote de Nacre, 14033 Caen Cedex, France
    Diabetes Metab 28:27-32. 2002
    ..ID ACE polymorphism modulates ACE level whereas M235T AGT polymorphism is involved in arterial hypertension. The A1166C AT1R polymorphism is involved in arterial hypertension and in diabetic retinopathy.
  86. ncbi A1166C polymorphism of the angiotensin II type 1 receptor gene and essential hypertension in Han, Tibetan and Yi populations
    Ying Liu
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, PR China
    Hypertens Res 25:515-21. 2002
    ..substitution of cytosine for adenine at position 1166 (A1166C) polymorphism of the angiotensin II type 1 receptor (AT1R) gene is associated with susceptibility to essential hypertension in Han, Tibetan and Yi populations in China...
  87. ncbi A/C1166 gene polymorphism of the angiotensin II type 1 receptor (AT1) and ambulatory blood pressure: the Ohasama Study
    Masahiro Kikuya
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan
    Hypertens Res 26:141-5. 2003
    ..A/C1166 gene polymorphism in the 3' untranslated region of the angiotensin II type 1 receptor (AT1) gene is the final remaining major target in R-A-A to be examined in the Ohasama Study population...
  88. ncbi Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease
    Monika Buraczynska
    Chair and Department of Nephrology, Medical Academy, Lublin, Poland
    Kardiol Pol 58:1-9. 2003
    ..Angiotensinconverting enzyme (ACE), angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1R) gene polymorphisms are considered risk factors in coronary heart disease (CHD).
  89. ncbi Angiotensin converting enzyme I/D, angiotensinogen T174M-M235T and angiotensin II type 1 receptor A1166C gene polymorphisms in Turkish hypertensive patients
    Bedia Agachan
    University of Istanbul, Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul, Turkey
    Exp Mol Med 35:545-9. 2003
    ..81%). Frequency of ATR1 C allele (AC+CC genotypes) was found higher hypertensives than controls (39.4% vs 25.9%; P = 0.054). Our results suggest that an interaction exists between the RAS genes and hypertension in Turkish population...
  90. ncbi Renin-angiotensin system and associated gene polymorphisms in myocardial infarction in young South African Indians
    N Ranjith
    Department of Medicine and the Coronary Care Unit, R K Khan Hospital, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Cardiovasc J S Afr 15:22-6. 2004
    ..in genetic components of this system, such as the angiotensin-converting enzyme (ACE) gene, angiotensin II type 1 (AT1) receptor gene and angiotensinogen (AGT) gene, may cause a variety of adverse cardiovascular effects...
  91. ncbi Gene polymorphisms of the renin-angiotensin-aldosterone system and the risk of ischemic stroke: a role of the A1166C/AT1 gene variant
    Speranza Rubattu
    IRCCS Neuromed, Pozzilli Is, Department of Cardiology, IInd School of Medicine, University La Sapienza, Ospedale Sant Andrea, Rome, Italy
    J Hypertens 22:2129-34. 2004
    ..In the present study we characterized the contributory role of RAAS genes in the susceptibility to develop ischemic stroke in humans...
  92. ncbi Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: the Ohasama Study
    Ken Sugimoto
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 27:551-6. 2004
    Gene targeting approaches have suggested that the angiotensin II type 1 receptor (AT1R) is involved in blood pressure (BP) regulation and modulation of the effect of angiotensin II...
  93. ncbi beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation
    William G Barnes
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:8041-50. 2005
    ....
  94. ncbi Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis
    Dacia L Hunton
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Box 3821, Duke University Medical Center, Durham, NC 27710, USA
    Mol Pharmacol 67:1229-36. 2005
    ..These data suggest that beta-arrestin 2 can mediate chemotaxis through mechanisms which may be G-protein-independent (Ang II receptors) or -dependent (LPA receptors)...
  95. ncbi Genetic polymorphisms of the renin-angiotensin-aldosterone system and renal insufficiency in essential hypertension
    Bruno Fabris
    Department of Medicina Clinica and Neurologia, University of Trieste, Trieste, Italy
    J Hypertens 23:309-16. 2005
    ..The aim of the present study was to evaluate the relation between four genetic polymorphisms of the RAAS and renal insufficiency in a population of patients with essential hypertension living in north-east Italy...
  96. ncbi Genetic variation of the renin-angiotensin system and chronic kidney disease progression in black individuals in the atherosclerosis risk in communities study
    Charles Chia Chuen Hsu
    Department of Epidemiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Am Soc Nephrol 17:504-12. 2006
    ..In white individuals, the A1166C 3'-UTR variant of angiotensin II type 1 receptor (AT1R) has been associated with CKD. CKD associations with these RAS genes are uncertain in high-risk black populations...
  97. ncbi Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, and Department of Medical Genetics and Child Development, University of Pecs, Hungary
    J Mol Neurosci 28:285-90. 2006
    Recent observations revealed a novel role of angiotensin-converting enzyme 2 and the angiotensin II type-1 receptor (AT1R) in lung injury, thereby extending knowledge about the functions of the angiotensin system...
  98. pmc Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Genomics 89:362-9. 2007
    ..system has been linked to the production of PAI-1 expression via the angiotensin II type 1 receptor (AT1R). In addition, bradykinin can induce the release of t-PA through a B2 receptor mechanism...
  99. pmc The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding
    Mickey M Martin
    Davis Heart and Lung Institute, The Ohio State University, Ohio 43210, USA
    J Biol Chem 282:24262-9. 2007
    The adverse effects of angiotensin II (Ang II) are primarily mediated through the Ang II type 1 receptor (AT1R)...
  100. doi Characterization of RNA-binding proteins possibly involved in modulating human AT 1 receptor mRNA stability
    Aldo Pende
    Department of Internal Medicine, University of Genoa School of Medicine, Genoa, Italy
    Cell Biochem Funct 26:493-501. 2008
    ..Our findings allow identification of specific RNA-binding proteins possibly involved in the control of the hAT1-receptor mRNA stability and in the regulation of their expressions...
  101. pmc Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells
    Hewang Li
    Department of Pediatrics, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA
    J Clin Invest 118:2180-9. 2008
    ..expression of both the antihypertensive dopamine 5 receptor (D5R) and the prohypertensive Ang II type 1 receptor (AT1R). In this report, we investigated the in vivo and in vitro interaction between these GPCRs...

Research Grants67

  1. Role of the Renin-Angiotensin system in placental insufficiency
    Eugenia Mata-Greenwood; Fiscal Year: 2013
    ..characterized by higher Angiotensin II, Angiotensin I-converting enzyme (ACE) and Angiotensin II receptor 1 (AGTR1) expression. In addition, late-pregnant BN dams were hypertensive and proteinuric...
  2. Tahir Hussain; Fiscal Year: 2016
    ..Of the two Ang II receptors, AT1 is known to mediate most of the Ang II actions such as antinatriuresis and increased blood pressure (BP)...
  3. Role of angiotensin II receptor signaling pathways in body fluid homeostasis
    Derek Daniels; Fiscal Year: 2013
    ..These behavioral effects are mediated largely through AngII type 1 (AT1) receptors, which stimulate several intracellular signaling pathways including one that leads to increased inositol ..
  4. Pharmacologic Interventions for Cardiovascular Disease in Obstructive Sleep Apnea
    Barbara J Morgan; Fiscal Year: 2013
    ..The specific aims of this application are: 1) Determine if treatment with losartan, an angiotensin type I receptor (AT1R) antagonist, or allopurinol, a XO inhibitor, normalize chemoreflex control of sympathetic outflow and ventilation ..
  5. Central Angiotensin receptors and teh neural control of homeostasis
    ERIC GERALD KRAUSE; Fiscal Year: 2013
    ..II (ANGII), exerts the majority of its biological effects via activation of angiotensin type 1 receptors (AT1R)...
  6. Mohammad Asghar; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Renal dopamine D1 and angiotensin II AT1 receptors by regulating proximal tubular sodium transporters maintain sodium homeostasis and blood pressure...
  7. 2010 Angiotensin Gordon Research Conference
    Kathy K Griendling; Fiscal Year: 2010
    ..of angiotensin-based therapies - from the serendipitous identification of ACE inhibitors in snake venom, through AT1 receptor blockers, renin inhibitors, AT2 receptor agonists, recombinant ACE2 therapies as well as the latest ..
  8. Brain specific non-AT1, non-AT2 angiotensin binding site
    ROBERT CHARLES SPETH; Fiscal Year: 2010
    ..We recently discovered a non-AT1, non-AT2 binding site in the brain that may add an additional layer of complexity to the brain angiotensin system...
  9. JAMES RUSSELL SOWERS; Fiscal Year: 2015
    ..A cohort of animals will be treated with an AT1R blocker (olmesartan) at a dose of 0...
  10. AT1R-regulated nuclear functions of Gb2
    Sadashiva S Karnik; Fiscal Year: 2012
    ..which may be important for the regulation of genes in response to over activity of the angiotensin type 1 receptor (AT1R)...
  11. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2013
    ..The angiotensin (Ang) converting enzyme (ACE), Ang II and Ang AT1 receptor of the renin-angiotensin system (RAS) participate in the pathophysiology of various cardiovascular ..
  12. Renal AT2 Receptors in Hypertension
    ROBERT MUNSON CAREY; Fiscal Year: 2013
    ..Angiotensin II (Ang II), the main effector peptide of the RAS, acts at two major receptors, AT1 and AT2...
  13. Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
    Raouf A Khalil; Fiscal Year: 2010
    ..AngII activates angiotensin type 1 receptor (AT1R) to induce vasoconstriction, and angiotensin type 2 receptor (AT2R) to induce the release of vasodilator substances ..
  14. Steven D Crowley; Fiscal Year: 2016
    ..We therefore suggest that Ang II acting through type I angiotensin (AT1) receptors promotes the development of a Th1 immune response in the kidney, with enhanced production of IFN-g and ..
  15. Mechanisms of action of angiotensin-II on C1 neurons.
    Seth D DePuy; Fiscal Year: 2010
    ..Under pathological conditions, upregulation of the RAS, including AT1 receptors and angiotensin converting enzyme (ACE), produces a tonic activation of presympathetic neurons that can ..
  16. Molecular Mechanism of PGE2 Receptor Pressor Effects
    Richard M Breyer; Fiscal Year: 2011
    ..In vitro studies will focus on the downstream receptor signal transduction of AT1 angiotensin receptor and PGE2 EP receptors to investigate evidence of receptor synergy...
  17. NAHID JAMAL RIANON; Fiscal Year: 2014
    ..ACEI prevents generation of angiotensin II, which impacts bone via receptors AT1 and AT2...
  18. ANGIOTENSIN RECEPTOR GENES AND BLOOD PRESSURE REGULATION
    Thomas M Coffman; Fiscal Year: 2010
    ..In hypertension on the other hand, we found that AT1 receptors in the kidney play the dominant role, whereas AT1 receptors outside the kidney have little impact...
  19. Risk factor-enhanced microvascular responses to ischemia-reperfusion.
    D Neil Granger; Fiscal Year: 2013
    ..is increased in the presence of cardiovascular risk factors (HCh and/or HTN) due to angiotensin II type 1 receptor (AT1r)-mediated release of cytokines from circulating immune cells...
  20. Central actions of angiotensin II in the control of fluid balance
    Daniel K Yee; Fiscal Year: 2013
    ..The Type 1 (AT1) AngII receptor subtype is primarily responsible for the physiological and behavioral responses to this peptide...
  21. Molecular Basis of Ang II Receptor Functions
    Sadashiva S Karnik; Fiscal Year: 2013
    ..goal of our research program is to elucidate the structure-function basis of angiotensin II type 1 receptor (AT1R)...
  22. Sadashiva S Karnik; Fiscal Year: 2015
    ..mechanisms that alter normal regulation of genes in response to overactivity of the angiotensin II type 1 receptor (AT1R)...
  23. Central AT1 receptors and the integrated stress response.
    ERIC GERALD KRAUSE; Fiscal Year: 2010
    ..In this regard, our recent study found that circulating ANGII drives activation of the HPA axis by stimulating AT1R in the subfornical, a specialized forebrain structure that binds blood-borne hormones...
  24. Central GRK5 modulation of Angiotensin II receptor expression in heart failure
    KARLA HAACK; Fiscal Year: 2013
    ..proposal will address the following specific aims: (1) Determine the role(s) of central GRK5 in the regulation of AT1R (Angiotensin II type 1 Receptor) expression under normal conditions and during Chronic Heart Failure (CHF)...
  25. EUGENE JOSEPH BARRETT; Fiscal Year: 2015
    ..diseases (CVD);B) a rationale for the previously observed salutory clinical effects of metformin, type 1 angiotensin II receptor (AT1R) blockers, mineralocorticoid receptor (MR) blockers and diet/exercise on CVD and;C) a basis to ..
  26. Horng H Chen; Fiscal Year: 2016
    ..We demonstrated that angiotensin II receptor (AT1) blockade prevented the detrimental renal effects of diuretics...
  27. Salt appetite & vascular remodeling in fetal origin
    Zhice Xu; Fiscal Year: 2010
    ..the effects of maternal high salt ingestion on the development of fetal swallowing behavior, ANG receptor subtypes-AT1?R and AT2-R, and vascular homeostasis, as well as long-term programming influence on cardiovascular regulation in ..
  28. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford C Berk; Fiscal Year: 2012
    ..has been proven by the positive clinical benefits associated with ACE inhibitors and angiotensin type 1 receptor (AT1R) blockers...
  29. Novel Aspects of the Cardiac Renin-Angiotensin System
    KENNETH MELVIN BAKER; Fiscal Year: 2012
    ..The effects of angiotensin II (Ang II) are primarily mediated by binding to AT1 receptor in an endocrine and/or autocrine/paracrine manner...
  30. Strategies for ACE2 Amplification to Treat Diabetic Kidney Disease
    Daniel Batlle; Fiscal Year: 2012
    ..approach of either inhibiting angiotensin II formation using ACE inhibitors or blocking its action using specific AT1 receptor antagonists...
  31. JAMES RUSSELL SOWERS; Fiscal Year: 2016
    ..A cohort of animals will be treated with an AT1R blocker or a mineralocortiod receptor in doses determined by telemetry to have no effect on blood pressure in mice...
  32. Utpal Sen; Fiscal Year: 2015
    ..WT (C57BL/6J) mouse, genetic mouse model of HHcy (CBS) and mouse deficient with angiotensin receptor I (AT1R-/-) will be used in this study...
  33. ROLE OF GLUCOSE IN hAT1 GENE EXPRESSION
    Thomas Thekkumkara; Fiscal Year: 2009
    ..Compared to rat in which two genes (AT1A, AT1B) code for AT1 receptor, in humans, a single gene code for angiotensin type 1 (hAT1), suggesting species specific ..
  34. Analia Loria; Fiscal Year: 2015
    ..Given the fact that RSNA can increase AngII type 1 (AT1) receptor expression, we speculate that increased baseline RSNA in MS rats results in increased renal AngII system ..
  35. Early Life Stress &Chronic Control of Blood Pressure
    Analia Loria; Fiscal Year: 2013
    ..Given the fact that RSNA can increase AngII type 1 (AT1) receptor expression, we speculate that increased baseline RSNA in MS rats results in increased renal AngII system ..
  36. Babbette LaMarca; Fiscal Year: 2016
    ..cytokines, neutrophils and lymphocytes producing an agonistic autoantibody to the angiotensin II type I receptor (AT1-AA)...
  37. The role of T lymphocytes in mediating hypertension during pregnancy
    Kedra L Wallace; Fiscal Year: 2013
    ..cytokines, neutrophils and lymphocytes producing an agonistic autoantibody to the angiotensin II type I receptor (AT1-AA)...
  38. Robin L Davisson; Fiscal Year: 2014
    ..In previous cycles of this grant, we have shown that AngII (type 1 receptor, AT1R)- induced reactive oxygen species (ROS) signaling in the SFO mediates "slow-pressor" AngII HTN, a chronic mouse ..
  39. Novel Roles of Intracrine Angiotensin II in Proximal Tubule Cells
    Jia Zhuo; Fiscal Year: 2009
    ..In the absence of apical AT1a receptors, AT1b receptors or the endocytic receptor megalin are unable to assume the role of AT1a receptors...
  40. Novel Roles of Intracrine Angiotensin II in Proximal Tubule Cells
    Jia L Zhuo; Fiscal Year: 2013
    ..In the absence of apical AT1a receptors, AT1b receptors or the endocytic receptor megalin may partially assume the role of AT1a receptors...
  41. Nitroalkenes and Blood Pressure Regulation
    Yuqing Eugene Chen; Fiscal Year: 2012
    ..data suggest that peroxisome proliferator-activated receptor-? (PPAR?) and angiotensin II (Ang II) type 1 receptor (AT1R) are two critical determinants that may provide functional links between obesity/diabetes, hypertension and ..
  42. Colin Sumners; Fiscal Year: 2014
    ..is critical and highly significant to uncovering the reasons for persistent over activity of central Ang II/AT1R mechanisms in high blood pressure and ultimately to the development of new therapeutic interventions...
  43. Natriuretic Mechanisms Uderlying Spontaneous Hypertension
    Shetal H Padia; Fiscal Year: 2012
    ..type-2 (AT2R) receptor has been shown to mediate natriuresis in response to renal angiotensin type-1 receptor (AT1R) blockade and direct agonist stimulation with angiotensin'III (Ang III)...
  44. Crystallization and structure determination of the angiotensin II type 1 receptor
    Brian K Kobilka; Fiscal Year: 2012
    ..There are three distinct classes of drugs for the AT1aR: (1) classical antagonists, angiotensin receptor blockers (ARBs) that stabilize the receptor in an inactive ..
  45. Pressure and Flow-Induced Remodeling of Coronary Arteries
    Ghassan S Kassab; Fiscal Year: 2010
    ..is that the circumferential stretch induced by increase in pressure (hypertension) or dilatation (FO) affects the AT1R which in turn upregulates Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase system...
  46. Local Vasoconstriction in Postural Tachycardia Syndrome
    Julian M Stewart; Fiscal Year: 2013
    ..activity or neurovascular sympathetic transduction caused by Ang-II binding to angiotensin type 1 receptors (AT1R) activating NADPH oxidase or Xanthine oxidase (XO) to produce ROS...
  47. Role of the Renin-Angiotensin System in the Regulation of Biliary Proliferation
    SHANNON STROUD GLASER; Fiscal Year: 2010
    ..disorders, induces cholangiocyte proliferation via mechanical activation of the angiotensin type 1 receptor (AT1)...
  48. Hiromi Yanagisawa; Fiscal Year: 2014
    ..In our preliminary studies, we show that the angiotensin II type 1 receptor (AT1R) blocker losartan effectively prevents aortic aneurysms with downregulation of p-ERK1/2 levels...
  49. Yves Boucher; Fiscal Year: 2014
    ..We have shown that the ATII receptor 1 (AT1R) antagonist losartan reduces desmoplasia and improves the delivery and effectiveness of cytotoxic agents in PDAC ..
  50. Qiuhong Li; Fiscal Year: 2015
    ..and fibrotic axis (angiotensin-converting enzyme [ACE]/angiotensin II [Ang II]/angiotensin type I receptor [AT1R]) of the renin- angiotensin-system (RAS) plays a central role in the pathogenesis of DR...
  51. POSTTRANSCRIPTIONAL REGULATION OF ANGIOTENSIN RECEPTORS
    KATHRYN L SANDBERG; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): In the rat, two distinct angiotensin type 1a receptor (AT1aR) mRNAs are synthesized from a single AT1aR gene. These transcripts are comprised of exons 1 and 3 (E1,3) and exons 1, 2 and 3 (E1,2,3)...
  52. Christie P Thomas; Fiscal Year: 2014
    ..to study alternate processing of the primary transcripts of FLT1, focusing on hypoxia and angiotensin II type 1 (AT1) receptor activation, two pathways that increase sFlt1 expression...
  53. Jean F Regal; Fiscal Year: 2015
    ..ischemia is that complement is activated by immune complexes of AT1-AA plus angiotensin II type 1 receptor (AT1R) leading to generation of activation products C3a and/or C5a, which invoke ET-1 and ROS pathways to ultimately ..
  54. The Mas Receptor is Required for Angiotensin-(1-7) Effects in Cardiac Remodeling
    Barry H Greenberg; Fiscal Year: 2012
    ..We have shown that Mas heterodimerization with the AT1 receptor affects AT1 expression and function...
  55. VASOACTIVE HORMONES: RECEPTORS AND SIGNALING MECHANISM
    Ulrich Hopfer; Fiscal Year: 2004
    ..and pharmacological observations have confirmed the existence of two major subtypes of angiotensin II receptors: AT1 receptors that are highly sensitive to biphenylimidazoles (e.g...
  56. Integrated Modeling of Adaptive Neuronal Regulation
    Rajanikanth Vadigepalli; Fiscal Year: 2012
    ..The NTS neuronal response to Ang II, acting through AT1R, involves processes that affect neuronal electrophysiology via the interplay of (1) membrane ion channels modulated ..
  57. Steven D Crowley; Fiscal Year: 2015
    ..regulators of M1/M2 macrophage differentiation include T lymphocyte subpopulations and type 1 angiotensin (AT1) receptors on macrophages...
  58. Rama Natarajan; Fiscal Year: 2015
    ..Several studies have documented the biochemical and signaling mechanisms of Ang II actions via the type 1 receptor (AT1R) in VSMC...
  59. Frank M Faraci; Fiscal Year: 2016
    ..Detrimental effects of the RAS are commonly due to Ang II acting on AT1 receptors resulting in activation of many downstream targets and oxidative stress...
  60. ADAM activation by Angiotensin II
    Satoru Eguchi; Fiscal Year: 2012
    Angiotensin II (AngII) and its G protein-coupled AT1 receptor play critical roles in mediating cardiovascular diseases such as hypertension, atherosclerosis, and restenosis after vascular injury...
  61. AngII-Salt Hypertension Increases Respiratory-Vasomotor Neuron Coupling in RVLM
    Glenn M Toney; Fiscal Year: 2013
    ..these data led us to formulate the following specific aims: (1) To test the hypothesis that PVN inputs and AT1R activation in the RVLM are important in the development and maintenance of AngII-salt HTN...
  62. Roles of Phospholipase D in AT1 Receptor Endocytosis
    Guangwei Du; Fiscal Year: 2010
    The angiotensin II type I receptor (AT1R) mediates diverse intracellular responses to angiotensin II (Ang II) in the regulation of blood pressure, hydromineral balance, cardiac hypertrophy and cell proliferation...
  63. RENAL AT1A RECEPTORS AND REGULATION OF BLOOD PRESSURE
    Michael Oliverio; Fiscal Year: 1999
    ..These experiments should allow us to separately assess the contributions of renal versus systemic AT1A receptors to circulatory homeostasis with a specificity that has not been possible previously. ..
  64. ANGIOTENSIN II RECEPTOR SIGNALING DOMAINS
    Robert Wayne Alexander; Fiscal Year: 2010
    ..II (AngII) is a potent stimulator of vascular hypertrophy which is mediated through the Ang II typel receptor (AT1R) in vascular smooth muscle cells (VSMCs)...
  65. Angiotensin II Receptor Blockade and Chronic Rejection
    Bryan Becker; Fiscal Year: 2003
    ..We have available therapies to alter this axis by pharmacological blockade of the predominant Ang II receptor, AT1R, and this treatment reduces TGF-beta levels in experimental studies...
  66. OXIDATIVE STRESS AND DIABETIC CARDIOMYOPATHY
    Piero Anversa; Fiscal Year: 2003
    ..II Hyperglycemia-mediated enzymatic glycosylation of p53 may enhance transcription of angiotensinogen (Aogen) and AT1 receptor; Aogen is the limiting factor in the generation of Ang II and the AT1 effector pathway conditions cardiac ..
  67. Fetal origins of adult hypertension in microswine
    Susan Bagby; Fiscal Year: 2007
    ..generation; and 2) increased renal microvascular contractile reactivity to AnglI despite reduced AT1 receptor (AT1R) density, suggesting post-receptor enhancement of AT1R contractile signaling efficiency...