AGR2

Summary

Gene Symbol: AGR2
Description: anterior gradient 2, protein disulphide isomerase family member
Alias: AG-2, AG2, GOB-4, HAG-2, HEL-S-116, HPC8, PDIA17, XAG-2, anterior gradient protein 2 homolog, anterior gradient homolog 2, epididymis secretory protein Li 116, protein disulfide isomerase family A, member 17, secreted cement gland homolog, secreted cement gland protein XAG-2 homolog
Species: human

Top Publications

  1. ncbi hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines
    D A Thompson
    Department of Surgery, Stanford University, Stanford, California, 94305 5494, USA
    Biochem Biophys Res Commun 251:111-6. 1998
  2. ncbi Localization of the human anterior gradient-2 gene (AGR2) to chromosome band 7p21.3 by radiation hybrid mapping and fluorescencein situ hybridisation
    E Petek
    Institute of Medical Biology and Human Genetics, University of Graz, Austria
    Cytogenet Cell Genet 89:141-2. 2000
  3. pmc hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan
    G C Fletcher
    Oxford GlycoSciences, Abingdon, Oxon, UK
    Br J Cancer 88:579-85. 2003
  4. ncbi AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer
    Jin San Zhang
    Department of Urology, Mayo Clinic College of Medicine, Mayo Clinic Foundation, Rochester, MN 55905, USA
    Genes Chromosomes Cancer 43:249-59. 2005
  5. ncbi Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family
    Staffan Persson
    Department of Plant Biochemistry, Lund University, SE 22100 Lund, Sweden
    Mol Phylogenet Evol 36:734-40. 2005
  6. ncbi Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease
    W Zheng
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Genes Immun 7:11-8. 2006
  7. ncbi Prognostic relevance of AGR2 expression in breast cancer
    Florian Rudolf Fritzsche
    Institute of Pathology and Breast Centre, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Clin Cancer Res 12:1728-34. 2006
  8. ncbi Increased expression of anterior gradient-2 is significantly associated with poor survival of prostate cancer patients
    Y Zhang
    Molecular Pathology Laboratory, School of Cancer Studies, The University of Liverpool, Liverpool, UK
    Prostate Cancer Prostatic Dis 10:293-300. 2007
  9. ncbi Physiological stress induces the metastasis marker AGR2 in breast cancer cells
    Daniel R Zweitzig
    Temple University School of Medicine, Fels Institute for Cancer Research, Philadelphia, PA 19140, USA
    Mol Cell Biochem 306:255-60. 2007
  10. doi Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer
    Manuel Valladares-Ayerbes
    Medical Oncology and Institute for Biomedical Research INIBIC, Juan Canalejo University Hospital, Spain
    Cancer Detect Prev 32:236-50. 2008

Research Grants

  1. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
  2. Steven M Lipkin; Fiscal Year: 2015
  3. Airway Epithelial Responses to Allergic Inflammation
    David J Erle; Fiscal Year: 2010
  4. Novel Molecules in Airway Epithelial Endoplasmic Reticulum
    Bradley W Schroeder; Fiscal Year: 2012
  5. Specialized molecules with essential roles in mucus production
    David J Erle; Fiscal Year: 2013
  6. Alvin Y Liu; Fiscal Year: 2015
  7. Caitlin C O'Meara; Fiscal Year: 2015
  8. The Role of AGR2 in a Murine Model of Pancreatic Adenocarcinoma
    Anson W Lowe; Fiscal Year: 2012
  9. CELLULAR ASSEMBLY AND TRANSPORT OF THE IGE RECEPTOR
    Michael Robertson; Fiscal Year: 2004
  10. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003

Detail Information

Publications167 found, 100 shown here

  1. ncbi hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines
    D A Thompson
    Department of Surgery, Stanford University, Stanford, California, 94305 5494, USA
    Biochem Biophys Res Commun 251:111-6. 1998
    ..Coexpression of hAG-2 with ER suggests that hAG-2 may be involved in the tumor biology specific to the well-differentiated phenotype of hormonally-responsive breast cancers...
  2. ncbi Localization of the human anterior gradient-2 gene (AGR2) to chromosome band 7p21.3 by radiation hybrid mapping and fluorescencein situ hybridisation
    E Petek
    Institute of Medical Biology and Human Genetics, University of Graz, Austria
    Cytogenet Cell Genet 89:141-2. 2000
  3. pmc hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan
    G C Fletcher
    Oxford GlycoSciences, Abingdon, Oxon, UK
    Br J Cancer 88:579-85. 2003
    ..hAG-2 and hAG-3 may therefore serve as useful molecular markers and/or potential therapeutic targets for hormone-responsive breast tumours...
  4. ncbi AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer
    Jin San Zhang
    Department of Urology, Mayo Clinic College of Medicine, Mayo Clinic Foundation, Rochester, MN 55905, USA
    Genes Chromosomes Cancer 43:249-59. 2005
    b>AGR2, the human homologue of Xenopus anterior gradient 2 (XAG2), was identified by a suppression subtractive hybridization-based technique as an androgen-inducible gene...
  5. ncbi Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family
    Staffan Persson
    Department of Plant Biochemistry, Lund University, SE 22100 Lund, Sweden
    Mol Phylogenet Evol 36:734-40. 2005
  6. ncbi Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease
    W Zheng
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Genes Immun 7:11-8. 2006
    ..The genes encoding for the human homologues AGR2 and AGR3 are localized on chromosome 7p21.3...
  7. ncbi Prognostic relevance of AGR2 expression in breast cancer
    Florian Rudolf Fritzsche
    Institute of Pathology and Breast Centre, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Clin Cancer Res 12:1728-34. 2006
    We aimed to evaluate the expression of the human anterior gradient-2 (AGR2) in breast cancer on RNA and protein level and to correlate it with clinicopathologic data, including patient survival.
  8. ncbi Increased expression of anterior gradient-2 is significantly associated with poor survival of prostate cancer patients
    Y Zhang
    Molecular Pathology Laboratory, School of Cancer Studies, The University of Liverpool, Liverpool, UK
    Prostate Cancer Prostatic Dis 10:293-300. 2007
    Anterior gradient-2 (AGR2) expression was examined in a series of prostate cell lines and in an archival set of prostate tissues. The relative levels of AGR2 expression in the malignant cell lines PC-3 and PC-3M were, respectively, 5...
  9. ncbi Physiological stress induces the metastasis marker AGR2 in breast cancer cells
    Daniel R Zweitzig
    Temple University School of Medicine, Fels Institute for Cancer Research, Philadelphia, PA 19140, USA
    Mol Cell Biochem 306:255-60. 2007
    ..These studies identify the developmental gene product, anterior gradient 2 (AGR2) as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen...
  10. doi Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer
    Manuel Valladares-Ayerbes
    Medical Oncology and Institute for Biomedical Research INIBIC, Juan Canalejo University Hospital, Spain
    Cancer Detect Prev 32:236-50. 2008
    ..Our study aims to identify novel gastrointestinal cancer-specific markers for circulating tumor cell detection...
  11. pmc Anterior gradient-2 is overexpressed by fibrolamellar carcinomas
    Perumal Vivekanandan
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Hum Pathol 40:293-9. 2009
    ..In conclusion, anterior gradient-2 is overexpressed in the majority of fibrolamellar carcinomas but is only rarely overexpressed in hepatocellular carcinomas...
  12. pmc The protein disulfide isomerase AGR2 is essential for production of intestinal mucus
    Sung Woo Park
    Lung Biology Center and Program in Immunology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:6950-5. 2009
    ..A recent homology-based search for additional PDI family members identified anterior gradient homolog 2 (AGR2), a protein originally presumed to be secreted by intestinal epithelial cells...
  13. ncbi Prognostic significance of AGR2 in pancreatic ductal adenocarcinoma
    Marc Oliver Riener
    Institute of Surgical Pathology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    Histol Histopathol 24:1121-8. 2009
    The human Anterior Gradient-2 (AGR2) is strongly upregulated in various human cancers, including pancreatic ductal adenocarcinomas (PDAC), but its prognostic value in PDAC has not yet been studied.
  14. pmc The metastasis-associated anterior gradient 2 protein is correlated with poor survival of breast cancer patients
    Dong L Barraclough
    Cancer Tissue Bank Research Centre, University of Liverpool, UK
    Am J Pathol 175:1848-57. 2009
    The secreted metastasis-inducing protein, human anterior gradient 2 (AGR2), has been independently reported to be associated with either a reduced or an increased survival of different groups of patients with breast cancer...
  15. pmc ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer
    Yuexing Zhang
    Greenebaum Cancer Center and Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 70:240-8. 2010
    Dysregulation of the developmental gene anterior gradient protein 2 (AGR2) has been associated with a metastatic phenotype, but its mechanism of action and control in prostate cancers is unknown...
  16. doi 2,3,7,8-tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by upregulating expression of the metastasis marker agr2 in the hepatocarcinoma cell line HepG2
    Ariane Ambolet-Camoit
    INSERM UMR S 747, 75006 Paris, France
    Toxicol Sci 115:501-12. 2010
    ..interfering RNA knockdown experiments, we found that the newly described metastasis marker, anterior gradient-2 (AGR2), is involved in this effect...
  17. pmc Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia
    Ru Chen
    GI Division Department of Medicine, University of Washington, Seattle, WA 98195 USA
    Mol Cancer 9:149. 2010
    ..We applied quantitative proteomics to identify aberrantly elevated proteins in pancreatic juice samples derived from patients with PanIN3...
  18. doi A divergent substrate-binding loop within the pro-oncogenic protein anterior gradient-2 forms a docking site for Reptin
    Magdalena M Maslon
    Cancer Research UK p53 Signal Transduction Laboratories, Cell Signalling Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EX4 2XR, Scotland, UK
    J Mol Biol 404:418-38. 2010
    Anterior gradient-2 (AGR2) functions in a range of biological systems, including goblet cell formation, limb regeneration, inhibition of p53, and metastasis...
  19. doi The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection
    Huajie Bu
    Department of Urology, Division of Experimental Urology, Innsbruck Medical University, Innsbruck, Austria
    Prostate 71:575-87. 2011
    b>AGR2 is a member of the endoplasmatic reticulum protein disulphide isomerase gene family implicated in tumor metastasis. Its expression pattern, function, and utility as a marker remains to be further investigated.
  20. pmc Differential expression of anterior gradient gene AGR2 in prostate cancer
    Erin L Maresh
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    BMC Cancer 10:680. 2010
    The protein AGR2 is a putative member of the protein disulfide isomerase family and was first identified as a homolog of the Xenopus laevis gene XAG-2. AGR2 has been implicated in a number of human cancers...
  21. pmc AGR2, a mucinous ovarian cancer marker, promotes cell proliferation and migration
    Kyoungsook Park
    Samsung Biomedical Research Institute, Seoul, Korea
    Exp Mol Med 43:91-100. 2011
    ..To search for a biomarker for the early detection of ovarian cancer, we identified human anterior gradient 2 (AGR2) from our systematic analysis of paired normal and ovarian tumor tissue cDNA microarray...
  22. pmc The human adenocarcinoma-associated gene, AGR2, induces expression of amphiregulin through Hippo pathway co-activator YAP1 activation
    AiWen Dong
    Department of Medicine, Stanford University, Stanford, California 94305, USA
    J Biol Chem 286:18301-10. 2011
    b>Anterior Gradient Homolog 2 (AGR2) is expressed by the normal intestine and by most human adenocarcinomas, including those derived from the esophagus, pancreas, lung, breast, ovary, and prostate...
  23. doi Anterior gradient 2 overexpression in lung adenocarcinoma
    Marco Pizzi
    Department of Medical Diagnostic Sciences and Special Therapies, University of Padova, Padova, Italy
    Appl Immunohistochem Mol Morphol 20:31-6. 2012
    ..Querying the Oncomine database pinpointed anterior gradient 2 (AGR2) as being upregulated in lung AdC...
  24. pmc AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D
    Laurent Dumartin
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
    Cancer Res 71:7091-102. 2011
    ..Here, we investigated the role and mechanism of action of the metastasis-associated protein anterior gradient 2 (AGR2) in the pathogenesis of pancreatic cancer...
  25. pmc Role of pro-oncogenic protein disulfide isomerase (PDI) family member anterior gradient 2 (AGR2) in the control of endoplasmic reticulum homeostasis
    Arisa Higa
    Inserm U1053, Avenir, 33076 Bordeaux, France
    J Biol Chem 286:44855-68. 2011
    The protein-disulfide isomerase (PDI) family member anterior gradient 2 (AGR2) is reportedly overexpressed in numerous cancers and plays a role in cancer development...
  26. doi Development of an ELISA to detect the secreted prostate cancer biomarker AGR2 in voided urine
    Elizabeth A Wayner
    Antibody Resource, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Prostate 72:1023-34. 2012
    Comparative transcriptomics between sorted cells identified AGR2 as one of the highest up-regulated genes in cancer. Overexpression in primary tumors was verified by tissue microarray analysis...
  27. doi Serum AGR2 as an early diagnostic and postoperative prognostic biomarker of human lung adenocarcinoma
    Kyukwang Chung
    Department of Thoracic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
    Cancer Biomark 10:101-7. 2011
    In the present study, the human orthologue of the secreted Xenopus laevis anterior gradient 2 (AGR2) protein was evaluated as a potential serum biomarker of lung adenocarcinoma...
  28. pmc CD147 and AGR2 expression promote cellular proliferation and metastasis of head and neck squamous cell carcinoma
    Larissa Sweeny
    Department of Surgery, University of Alabama, Division of Otolaryngology Head and Neck Surgery, Birmingham, Alabama, USA
    Exp Cell Res 318:1788-98. 2012
    ..CD147 is a transmembrane glycoprotein known to induce cell migration and invasion. AGR2 is a secreted peptide also known to promote cell metastasis...
  29. doi Proteomic study explores AGR2 as pro-metastatic protein in HCC
    Hongxiu Yu
    Institutes of Biomedical Sciences, Fudan University, 130 Dong an Road, Shanghai, P R China 200032
    Mol Biosyst 8:2710-8. 2012
    ..We found that high-expression levels of AGR2 existed in metastatic HCC cell lines and patient samples...
  30. pmc AGR2 is a SMAD4-suppressible gene that modulates MUC1 levels and promotes the initiation and progression of pancreatic intraepithelial neoplasia
    A M Norris
    Department of Medicine, Dartmouth Medical School, Hanover, NH, USA
    Oncogene 32:3867-76. 2013
    The mechanisms controlling expression of the putative oncogene Anterior gradient 2 (AGR2) in pancreatic ductal adenocarcinoma (PDAC) are not well understood...
  31. doi Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion
    Pryank Patel
    Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
    J Mol Biol 425:929-43. 2013
    Anterior gradient 2 (AGR2) is a normal endoplasmic reticulum protein that has two important abnormal functions, amphibian limb regeneration and human cancer metastasis promotion...
  32. doi Anterior gradient 2 and mucin 4 expression mirrors tumor cell differentiation in pancreatic adenocarcinomas, but aberrant anterior gradient 2 expression predicts worse patient outcome in poorly differentiated tumors
    Veronika Brychtova
    From the Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute First Department of Pathological Anatomy, St Anne s University Hospital, Medical Faculty of Masaryk University Department of Complex Oncology Care, Masaryk Memorial Cancer Institute Department of Mathematics and Statistics, Faculty of Science, Masaryk University and Department of Surgery, University Hospital Brno, Medical Faculty of Masaryk University, Brno, Czech Republic
    Pancreas 43:75-81. 2014
    This study aimed to determine anterior gradient 2 (AGR2) expression in biopsies from pancreatic ductal adenocarcinomas (PDACs) and to evaluate AGR2 as a potential independent prognostic factor.
  33. ncbi Expression of anterior gradient 2 is decreased with the progression of human biliary tract cancer
    Su Jin Kim
    Department of Internal Medicine, Sejong General Hospital
    Tohoku J Exp Med 234:83-8. 2014
    ..The anterior gradient 2 (AGR2) is a protein disulfide isomerase and is highly expressed in various human cancers, such as breast, prostate and ..
  34. pmc Anterior gradient 2 is expressed and secreted during the development of pancreatic cancer and promotes cancer cell survival
    Vijaya Ramachandran
    Departments of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 68:7811-8. 2008
    ..In the current study, we investigated the role of anterior gradient 2 (AGR2) in these processes...
  35. pmc Anterior gradient-2 plays a critical role in breast cancer cell growth and survival by modulating cyclin D1, estrogen receptor-alpha and survivin
    Kathryn E Vanderlaag
    Schering Plough Biopharma, 901 South California Avenue, Palo Alto, CA 94304, USA
    Breast Cancer Res 12:R32. 2010
    Anterior-gradient 2 (AGR2) is an estrogen-responsive secreted protein...
  36. doi Differential expression of the anterior gradient protein-2 is a conserved feature during morphogenesis and carcinogenesis of the biliary tree
    Sebastien Lepreux
    INSERM U889, Universite Bordeaux 2, Bordeaux, France
    Liver Int 31:322-8. 2011
    The anterior gradient protein-2 (AGR2) is overexpressed in numerous tumours such as breast, prostate or pancreas carcinomas and recently reported in fibrolamellar hepatocellular carcinoma (HCC).
  37. pmc AGR2 gene function requires a unique endoplasmic reticulum localization motif
    Aparna Gupta
    Department of Medicine and the Stanford Digestive Disease Center, Stanford University, Stanford, California 94305, USA
    J Biol Chem 287:4773-82. 2012
    ..The present study determines whether AGR2 requires a specific ER localization signal to be functionally active...
  38. doi Emerging roles for the pro-oncogenic anterior gradient-2 in cancer development
    E Chevet
    Inserm U1053, Bordeaux, France
    Oncogene 32:2499-509. 2013
    ..The pro-oncogenic protein anterior gradient 2 (AGR2) is a case in point; AGR2 has been shown using a range of expression platforms to be involved in asthma, ..
  39. doi Dimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78
    Joohyun Ryu
    Medical Proteomics Research Center, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon 305 333, Republic of Korea
    Biochem Biophys Res Commun 430:610-5. 2013
    Anterior Gradient 2 (AGR2), an ER stress-inducible protein, has been reported to be localized in endoplasmic reticulum (ER) and its level is elevated in numerous metastatic cancers...
  40. pmc Prostate cancer cell phenotypes based on AGR2 and CD10 expression
    Melissa E Ho
    Department of Urology, University of Washington, Seattle, WA 98195 6100, USA
    Mod Pathol 26:849-59. 2013
    The combination of expression patterns of AGR2 (anterior gradient 2) and CD10 by prostate cancer provided four phenotypes that correlated with clinical outcome...
  41. doi Reactivity of ammonia ligands of the antitumor agent cisplatin: a unique dodecanuclear Pt4,Pd4,Ag4 platform for four cytosine model nucleobases
    Gunnar Kampf
    Fakultat Chemie, Technische Universitat Dortmund, Otto Hahn Strasse 6, Dortmund, Germany
    Chemistry 14:6882-91. 2008
    ..Two of the four Ag ions (Ag2, Ag2') of 10 are labile in solution and show the expected behavior of Ag(+) ions in water, that is, they are ..
  42. pmc Fimbriae and the hemagglutinating adhesin HA-Ag2 mediate adhesion of Porphyromonas gingivalis to epithelial cells
    L Du
    Equipe de Biologie Buccale, UPRES EA 1256, , France
    Infect Immun 65:3875-81. 1997
    ..gingivalis to epithelial cells and that the adhesins are likely associated with fimbriae and the hemagglutinating adhesin HA-Ag2.
  43. ncbi [Chitinase B from Bacillus thuringiensis enhancing potential and its antagonism and insecticidal]
    Dong Liu
    Department of Microbiology, Nankai University, Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin 300071, China
    Wei Sheng Wu Xue Bao 49:180-5. 2009
    ..We studied the characteristics of chitinase B (ChiB) from Bacillus thuringiensis subsp. colmeri 15A3 (Bt 15A3) and evaluated its antagonism and insecticidal potential...
  44. ncbi Metal-induced alterations of delta-aminolevulinic acid dehydratase
    A Bernard
    Industrial Toxicology and Occupational Medicine Unit, University of Louvain, Brussels, Belgium
    Ann N Y Acad Sci 514:41-7. 1987
    ..experiments show that ALAD can be activated or inhibited by several metal ions including A;3+, Pb2+, Cd2+, Hg2+, Ag2+, and Cu2+...
  45. ncbi Transfection of murine dendritic cell line (JAWS II) by a nonviral transfection reagent
    Shanjana Awasthi
    Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Biotechniques 35:600-2, 604. 2003
    ..for transfecting murine dendritic cells (JAWS II) with the gene that encodes Coccidioides immitis antigen 2 (Ag2). The JAWS II cells were cotransfected with pHYG-enhanced green fluorescent protein (EGFP) and pVR1012-C...
  46. pmc Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells
    David H Tompkins
    Division of Pulmonary Biology in the Perinatal Institute, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 4:e8248. 2009
    ..constructs for differentiation markers characteristic of Clara, ciliated, and goblet cells, Scgb1a1, FoxJ1, and Agr2, respectively...
  47. pmc Coccidioidomycosis: host response and vaccine development
    Rebecca A Cox
    Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, Texas Research Park, 15355 Lambda Dr, San Antonio, TX 78245 3027, USA
    Clin Microbiol Rev 17:804-39, table of contents. 2004
    ..multiple candidates, but the single best individual immunogen is the protein termed antigen 2/proline-rich antigen (Ag2/PRA)...
  48. ncbi Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease
    Josep Bassaganya-Riera
    Laboratory of Nutritional Immunology and Molecular Nutrition, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Gastroenterology 127:777-91. 2004
    ..We used a loss-of-function approach to investigate whether CLA ameliorated colitis through a peroxisome proliferator-activated receptor gamma (PPAR gamma)-dependent mechanism...
  49. ncbi Polymorphisms in the Paan-AG promoter influence NF-kappaB binding and transcriptional activity
    Daudi K Langat
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7400, USA
    Immunogenetics 59:359-66. 2007
    ..We cloned the promoters of two putative Paan-AG alleles (AG1 and AG2) and identified a number of regulatory elements including two kappaB sites...
  50. ncbi Amendment with peony root bark improves the biocontrol efficacy of Trichoderma harzianum against Rhizoctonia solani
    Tae Ok Lee
    Department of Agricultural Biotechnology and Center for Plant Molecular Genetics and Breeding Research, Seoul National University, Seoul 151 921, Korea
    J Microbiol Biotechnol 18:1537-43. 2008
    We tested Trichoderma harzianum as a biocontrol agent for Rhizoctonia solani AG2-1, using six natural antifungal materials to improve its efficacy...
  51. pmc SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production
    Gang Chen
    The Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati School of Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Clin Invest 119:2914-24. 2009
    ..goblet cell differentiation and protein glycosylation, including forkhead box A3 (Foxa3), anterior gradient 2 (Agr2), and glucosaminyl (N-acetyl) transferase 3, mucin type (Gcnt3)...
  52. ncbi Recent advances in serodiagnosis for cysticercosis
    Y Sako
    Department of Parasitology, Asahikawa Medical College, Hokkaido, Japan
    Southeast Asian J Trop Med Public Health 32:98-104. 2001
    ..proteins, we carried out molecular cloning and identified four diagnostic antigen candidates (Ag1, Ag1V1, Ag2, and Ag2V1)...
  53. ncbi Safety, antigenicity, and efficacy of a recombinant coccidioidomycosis vaccine in cynomolgus macaques (Macaca fascicularis)
    Suzanne M Johnson
    D V M M P V M, California National Primate Research Center, University of California, Davis, CA 95616, USA
    Ann N Y Acad Sci 1111:290-300. 2007
    The safety, immunogenicity and efficacy of recombinant Ag2/PRA106 + CSA chimeric fusion protein (CFP) vaccine in ISS/Montanide adjuvant-administered intramuscular (IM) was assessed in adult female cynomolgus macaques challenged with ..
  54. doi Metabolite composition and bioactivity of Rhizoctonia solani sclerotial exudates
    Konstantinos A Aliferis
    Department of Plant Science, McGill University, 21111 Lakeshore Road, Sainte Anne de Bellevue, QC H9X 3V9, Canada
    J Agric Food Chem 58:7604-15. 2010
    ..The sclerotia of the plant pathogen Rhizoctonia solani AG2-2 IIIB exude liquid brown droplets that were evaluated for their bioactivity and toxicity against microorganisms ..
  55. ncbi Establishment of 8-azaguanine-resistant mutants from rat thyroid cell line FRTL-5
    H Sugawa
    Second Division of Internal Medicine, Kyoto University School of Medicine, Japan
    Mol Cell Endocrinol 62:319-26. 1989
    ..were further selected in 6-thioguanine-containing medium, and two mutant clones were finally obtained (AG1 and AG2)...
  56. ncbi Rapid diagnosis of coccidioidomycosis by nested PCR assay of sputum
    R de Aguiar Cordeiro
    Medical Mycology Specialized Center, Post Graduation Program in Medical Sciences, Federal University of Ceara, Ceara, Brazil
    Clin Microbiol Infect 13:449-51. 2007
    ..posadasii DNA in an inappropriate sputum sample by PCR amplification of the highly specific Ag2/PRA antigen gene...
  57. doi Coccidioidal pericarditis: a rapid presumptive diagnosis by an in-house antigen confirmed by mycological and molecular methods
    Raimunda S N Brilhante
    Specialized Medical Mycology Center, Federal University of Ceara, Fortaleza, Ceara, Brazil
    J Med Microbiol 57:1288-92. 2008
    ..posadasii in-house antigen preparation. The C. posadasii identification was confirmed by nested PCR of the antigen 2/proline-rich antigen (Ag2/PRA) encoding gene.
  58. ncbi Anterior specification of embryonic ectoderm: the role of the Xenopus cement gland-specific gene XAG-2
    F Aberger
    Institute of Genetics, University of Salzburg, Hellbrunnerstrasse 34, A 5020, Salzburg, Austria
    Mech Dev 72:115-30. 1998
    ..Based on these findings we propose a role for XAG-2 in the specification of dorsoanterior ectodermal fate, i.e. in the formation of cement gland and induction of forebrain fate of Xenopus...
  59. ncbi Sequence and expression of Drosophila Antigen 5-related 2, a new member of the CAP gene family
    T Megraw
    Howard Hughes Medical Institute, Department of Biology, Indiana University, Bloomington, IN, USA
    Gene 222:297-304. 1998
    ..Because of its similarity to Agr, this novel cDNA was termed Antigen 5-related 2 (Agr2)...
  60. pmc Time-varying changes in corticospinal excitability accompanying the triphasic EMG pattern in humans
    C D MacKinnon
    MRC Human Movement and Balance Unit, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Physiol 528:633-45. 2000
    ..by the usual triphasic pattern of EMG activity in agonist (AG1), antagonist (ANTAG) and again in agonist (AG2) muscles...
  61. doi Strain-specific colonization pattern of Rhizoctonia antagonists in the root system of sugar beet
    Christin Zachow
    Institute of Environmental Biotechnology, Graz University of Technology, Graz, Austria
    FEMS Microbiol Ecol 74:124-35. 2010
    ..The survival and colonization patterns of five different biocontrol agents against Rhizoctonia solani AG2-2IIIB in the rhizosphere of greenhouse-grown sugar beet plants were analysed in single and combined treatments...
  62. ncbi Coccidioides immitis antigen 2: analysis of gene and protein
    Y Zhu
    Department of Clinical Investigation, Texas Center for Infectious Disease, San Antonio 78223, USA
    Gene 181:121-5. 1996
    ..Using oligodeoxyribonucleotide (oligo) primers based on the sequences of Ag2 cDNA, the gene encoding Ag2 was cloned from genomic DNA derived from the mycelial phase of C. immitis by PCR...
  63. ncbi Formation of mixed d- and f-block metal clusters in inert matrices: comparison of the observed and theoretical optical spectra of AgHo
    W E Klotzbücher
    Max Planck lnstitut für Strahlenchemie, Mülheimn a d Ruhr, Germany
    Spectrochim Acta A Mol Biomol Spectrosc 57:1093-101. 2001
    ..for the electronic excitation energies and corresponding transition dipole moments for the diatomic molecules Ag2, Ho2, AgHo provide evidence that the 430 nm band should be attributed to the mixed cluster AgHo (theoretical band ..
  64. doi Muscle activity patterns during quick increase of movement amplitude in rapid elbow extensions
    Nozomi Takatoku
    Graduate School of Humanities and Sciences, Nara Women s University, Nara, Japan
    J Electromyogr Kinesiol 20:290-7. 2010
    ..e., the first agonist burst (AG1), the second agonist burst (AG2) and the antagonist burst (ANT), for increasing the amplitude of movement required after the initiation of movement...
  65. pmc Significance of the Fanconi anemia FANCD2 protein in sporadic and metastatic human breast cancer
    Philip S Rudland
    Cancer and Polio Research Fund Laboratories, School of Biological Sciences, Biosciences Building, Crown Street, University of Liverpool, Liverpool, L69 3BX, United Kingdom
    Am J Pathol 176:2935-47. 2010
    ..associated with positive staining for the metastasis-inducing proteins S100A4, S100P, osteopontin, and AGR2 (P < or = 0.002). Survival of patients with FANCD2-negative carcinomas was significantly worse (P < 0...
  66. doi Global distribution and evolution of Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus, 1981-2007
    Jean Philippe Rasigade
    Universite Lyon 1, Centre National de Référence des Staphylocoques, and Institut National de la Santé et de la Recherche Médicale U851, Institut Fédératif de Recherche 128, Lyon, France
    J Infect Dis 201:1589-97. 2010
    ..The epidemiological profile of PVL-positive community-acquired (CA) MRSA has been extensively studied, but few corresponding data on PVL-positive MSSA are available...
  67. ncbi Allergy to rabbits. III. Further identification and characterisation of rabbit allergens
    J A Warner
    Child Health, Southampton University, UK
    Allergy 46:481-91. 1991
    ..Other allergens were only recognised by highly rabbit-sensitive individuals, one in particular (Ag2) being present in several source materials...
  68. ncbi Strategic expression of ion transport peptide gene products in central and peripheral neurons of insects
    Li Dai
    Department of Entomology, University of California, Riverside, California 92521, USA
    J Comp Neurol 500:353-67. 2007
    ..is observed in two pairs of small lateral neurons in the brain and one pair of ventromedial neurons in each of AG2-6. A similar pattern of differential ITP and ITPL expression was observed in the CNS and PNS of B...
  69. pmc SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells
    Taeko K Noah
    Division of Gastroenterology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Exp Cell Res 316:452-65. 2010
    ..Spdef has been reported to be expressed in the intestine. In this paper, we identify an important role for Spdef in regulating intestinal epithelial cell homeostasis and differentiation...
  70. pmc Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice
    Fang Zhao
    Department of Medicine and Biological Chemistry, University of California, Irvine, CA, USA
    Dev Biol 338:270-9. 2010
    Anterior Gradient 2 (AGR2) is a protein disulfide isomerase that plays important roles in diverse processes in multiple cell lineages as a developmental regulator, survival factor and susceptibility gene for inflammatory bowel disease...
  71. doi Synthesis and binding analysis of unique AG2 pentasaccharide to human Siglec-2 using NMR techniques
    Shinya Hanashima
    Structural Glycobiology Team, RIKEN Advanced Science Institute, Hirosawa 2 1, Saitama 351 0198, Japan
    Bioorg Med Chem 18:3720-5. 2010
    ..We synthesized a unique starfish ganglioside, AG2 pentasaccharide Galfbeta(1-3)Galpalpha(1-4)Neu5Acalpha(2-3)Galpbeta(1-4)Glcp, and found that the synthetic ..
  72. doi Predominant expression and cellular distribution of fish Agr2 in renal collecting system
    Jian Hong Xia
    Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Wuhan, China
    Comp Biochem Physiol B Biochem Mol Biol 152:397-404. 2009
    Anterior gradient 2 (Agr2) genes encode secretory proteins, and play significant roles in anterior-posterior patterning and tumor metastasis...
  73. pmc Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition
    J W Kappler
    J Exp Med 153:1198-214. 1981
    ..The tumor cell partner in the fusions was itself a T cell hybrid, FS6-14.13.AG2 (or its derivatives), which could be induced to produce the growth factor, interleukin-2 (IL-2), in response to a ..
  74. ncbi Gold(I) and silver(I) metallocryptates based on 2,9-bis(diphenylphosphino)-1,8-naphthyridine
    V J Catalano
    Department of Chemistry, University of Nevada, Reno, Reno, Nevada 89557
    Inorg Chem 39:121-7. 2000
    ..to that of the synthesis of 1, the reaction of equimolar AgNO3 with dppn produces the trimetallic species [Ag2(mu-dppn)3Ag](PF6)3 (3) as a bright-yellow material...
  75. ncbi Potassium thiocyanate argentates: K3[Ag(SCN)4], K4[Ag2(SCN)6] and K[Ag(SCN)2]
    H Krautscheid
    Institut fur Anorganische Chemie, Universitat Karlsruhe, Engesserstrasse 30 45, D 76128 Karlsruhe, Germany
    Acta Crystallogr C 57:781-3. 2001
    ..groups are bonded as terminal ligands, in tetrapotassium di-mu-thiocyanato-S:S-bis[dithiocyanatoargentate(I)], K4[Ag2(SCN)6], (II), two AgS4 tetrahedra share one common edge...
  76. ncbi Expression and localization of the linear DNA plasmid-encoded protein (RS224) in Rhizoctonia solani AG2-2
    Atsushi Nagasaka
    Department of Environmental Biotechnology, Graduate School of Agriculture, Tohoku University, Sendai 981 8555, Japan
    FEMS Microbiol Lett 225:41-6. 2003
    ..solani were disrupted and fractionated. Antibodies against RS224 proteins specifically reacted to the mitochondrial fraction, suggesting that RS224 is localized in mitochondria...
  77. ncbi Luminescent gold(I) and silver(I) complexes of 2-(diphenylphosphino)-1-methylimidazole (dpim): characterization of a three-coordinate Au(I)-Ag(I) dimer with a short metal-metal separation
    Vincent J Catalano
    Department of Chemistry, University of Nevada at Reno, Reno, Nevada 89557, USA
    Inorg Chem 42:8430-8. 2003
    ..dpim formed the discreet binuclear species [Ag2(dpim)2(CH3CN)2](2+) (1) when reacted with appropriate Ag(I) salts...
  78. ncbi catena-Poly[[bis(mu2-4-methylbenzoato-kappa2O:O')disilver(I)(Ag-Ag)]-mu2-di-2-pyridylamine-kappa2N2:N2'] and catena-poly[[(di-2-pyridylamine-kappaN2)(mu2-4-nitrobenzoato-kappa2O:O')disilver(I)(Ag-Ag)]-mu3-4-nitrobenzoato-kappa3O:O':O']
    Mamiko Odoko
    Faculty of Pharmaceutical Sciences, Kinki University, Kowakae 3 4 1, Higashiosaka, Osaka 577 8502, Japan
    Acta Crystallogr C 63:m22-6. 2007
    Both title compounds are polynuclear polymeric complexes with binuclear units. In the former compound, [Ag2(C8H7O2)2(C10H9N3)]n, the two Ag(I) atoms display distorted square-planar coordinations...
  79. doi Use of Galleria mellonella larvae to evaluate the in vivo anti-fungal activity of [Ag2(mal)(phen)3]
    Raymond Rowan
    Medical Mycology Unit, NICB, Department of Biology, National University of Ireland Maynooth, CO, Kildare, Ireland
    Biometals 22:461-7. 2009
    ..This work demonstrates that G. mellonella larvae may be employed to ascertain the antifungal efficacy of silver(I) compounds and offers a rapid and effective means of assessing the in vivo activity of inorganic antimicrobial compounds...
  80. pmc The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development
    Suman Verma
    Department of Medicine, University of California, Irvine, USA
    Dev Biol 369:249-60. 2012
    b>Agr2 is a putative protein disulfide isomerase (PDI) initially identified as an estrogen-responsive gene in breast cancer cell lines...
  81. doi Heteropolyhedral silver compounds containing the polydentate ligand N,N,O-E-[6-(hydroxyimino)ethyl]-1,3,7-trimethyllumazine. Preparation, spectral and XRD structural study and AIM calculations
    Sonia B Jiménez-Pulido
    Department of Inorganic and Organic Chemistry and Campus Las Lagunillas B3, University of Jaen, 23071 Jaen, Spain
    Dalton Trans 42:530-41. 2013
    ..asymmetrical residual unit of complexes 2, 3 and 5 contains two quite different but connected silver centers (Ag1-Ag2, 2.9-3.2 Å)...
  82. doi Syringophilopsis davidi sp. nov. (Prostigmata, Syringophilidae) a new quill mite species parasitizing Calandrella brachydactyla (Passeriformes, Alaudidae) in Egypt
    Eliza Glowska
    Faculty of Biology, Department of Animal Morphology, Adam Mickiewicz University, Poznan, Poland
    Acta Parasitol 57:385-7. 2012
    ..by 10-13 chambers of the peritremal lateral branches, setae se located slightly anterior to c1, and by setae ag2 about twice longer than the genital setae...
  83. pmc Agr genes, missing in amniotes, are involved in the body appendages regeneration in frog tadpoles
    Anastasiya S Ivanova
    1 Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Sci Rep 3:1279. 2013
    ..Here, we refined the phylogeny of Agrs, revealing three subfamilies: Ag1, Agr2 and Agr3...
  84. doi CFA-2 and CFA-3 (Coordination Framework Augsburg University-2 and -3); novel MOFs assembled from trinuclear Cu(I)/Ag(I) secondary building units and 3,3',5,5'-tetraphenyl-bipyrazolate ligands
    Maciej Grzywa
    Institute of Physics, Chair of Solid State and Materials Chemistry, Augsburg University, Universitatsstrasse 1, D 86159 Augsburg, Germany
    Dalton Trans 42:6909-21. 2013
    The syntheses of H2-phbpz, [Cu2(phbpz)]·2DEF·MeOH (CFA-2) and [Ag2(phbpz)] (CFA-3) (H2-phbpz = 3,3',5,5'-tetraphenyl-1H,1'H-4,4'-bipyrazole) compounds and their crystal structures are described...
  85. doi Subtractive screen of potential limb regeneration related genes from Pachytriton brevipes
    Dan Jiang
    Institute of Cellular and Developmental Biology, College of Life Sciences, Zhejiang University, 866 Yu Hang Tang Road, Hangzhou, 310058, Zhejiang, China
    Mol Biol Rep 41:1015-26. 2014
    ..And we further verified the differential expression of four candidate genes, Rpl11, Cirbp, Ag2 and Trimx, between regenerating blastema and non-regeneration tissues by in situ hybridization...
  86. doi Bispidine analogues of cisplatin, carboplatin, and oxaliplatin. synthesis, structures, and cytotoxicity
    Huiling Cui
    Max Planck Institut fur Kohlenforschung, Kaiser Wilhelm Platz 1, D 45470 Mulheim an der Ruhr, Germany
    Inorg Chem 53:3371-84. 2014
    ..Recrystallization of 1a,b from hot water yields the trihydrate (C7H14N2)PtCl2·3H2O (1c). Reaction of 1 with Ag2(cbdca) (cbdca = 1,1-cyclobutanedicarboxylate) in water affords the pentahydrate (C7H14N2)Pt{C4H6(CO2)2}·5H2O (2b), ..
  87. pmc Anterior gradient protein 2 promotes survival, migration and invasion of papillary thyroid carcinoma cells
    Gennaro Di Maro
    Dipartimento di Scienze Motorie e del Benessere, Universita Parthenope, Via Medina 40, Naples 80133, Italy
    Mol Cancer 13:160. 2014
    Through a transcriptome microarray analysis, we have isolated Anterior gradient protein 2 (AGR2) as a gene up-regulated in papillary thyroid carcinoma (PTC)...
  88. pmc Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer
    Tricia M Wright
    Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina
    Mol Cancer Res 12:1829-39. 2014
    ..in this regard is the observation here and in other studies that expression of anterior gradient homology 2 (AGR2), a known proto-oncogene and disulfide isomerase, was induced by both estrogen (17β-estradiol, E2) and 4-..
  89. doi Synthesis of Peptides by Silver-Promoted Coupling of Carboxylates and Thioamides: Mechanistic Insight from Computational Studies
    Craig A Hutton
    School of Chemistry and Bio21 Institute, The University of Melbourne, 30 Flemington Road, Parkville, Vic, 3010, Australia
    Chemistry 22:3163-9. 2016
    ..of the carboxylate to the thioamide, which is followed by deprotonation and silver-mediated extrusion of sulfur as Ag2 S...
  90. doi Cobalt-Catalyzed Oxidative C-H/C-H Cross-Coupling between Two Heteroarenes
    Guangying Tan
    Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu, 610064, P R China
    Angew Chem Int Ed Engl 55:10414-8. 2016
    ..The method can be extended to the reaction between an arene and a heteroarene. It is worth noting that the Ag2 CO3 oxidant is renewable...
  91. pmc The alluaudite-type crystal structures of Na2(Fe/Co)2Co(VO4)3 and Ag2(Fe/Co)2Co(VO4)3
    Mohammed Hadouchi
    Laboratoire de Chimie du Solide Appliquée, Faculty of Sciences, Mohammed V University in Rabat, Avenue Ibn Battouta, BP 1014, Rabat, Morocco
    Acta Crystallogr E Crystallogr Commun 72:1017-20. 2016
    ..cobalt tris-(orthovanadate), Na2(Fe/Co)2Co(VO4)3, and disilver di(cobalt/iron) cobalt tris-(orthovanadate), Ag2(Fe/Co)2Co(VO4)3, were grown from a melt consisting of stoichiometric mixtures of three metallic cation precursors ..
  92. ncbi Th1-type immune response to a Coccidioides immitis antigen delivered by an attenuated strain of the non-invasive enteropathogen Vibrio cholerae
    Anisia J Silva
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr, SW Atlanta, GA 30310 1495, USA
    FEMS Immunol Med Microbiol 43:393-8. 2005
    The antigen-2 or proline rich antigen (Ag2/PRA) from Coccidioides immitis, known to protect mice against experimental Coccidioidomycosis, was expressed in the genetically attenuated cholera vaccine candidate Vibrio cholerae 638 and its ..
  93. ncbi Coordination networks with fluorinated backbones
    Ye Gao
    Department of Chemistry, University of Idaho, Moscow, Idaho 83843 2343, USA
    Inorg Chem 45:1150-5. 2006
    ..AgNO3, Co(ClO4)2 x 6 H2O, and Cd(NO3)2 x 4 H2O, respectively, to form the following structures: 3D channel polymer [Ag2(1)2(NO3)2 x H2O x MeOH]n (3), 2D sheet polymer [Co(1)3(ClO4)2]n (4), 1D chain polymer [Cd(1)3(NO3)2 x 4 H2O]n (5), ..
  94. ncbi Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue
    C L Wilson
    Cancer Research UK Bioinformatics Group, Paterson Institute for Cancer Research, Wilmslow Road, Withington, Manchester M20 4BX, UK
    Endocr Relat Cancer 13:617-28. 2006
    ..as TFF1 and AREG), and genes thought to be involved in breast cancer metastasis (including mammoglobin, KRT19 and AGR2), were upregulated in response to E treatment...
  95. ncbi Effect of diatomaceous earth and Trichoderma harzianum T-22 (Rifai strain KRL-AG2) on the fungus gnat Bradysia sp. nr. coprophila (Diptera: Sciaridae)
    Raymond A Cloyd
    Department of Entomology, Kansas State University, Manhattan, KS 66506, USA
    J Econ Entomol 100:1353-9. 2007
    ..eggs; and whether fungus gnat adults are attracted to the fungus Trichoderma harzianum T-22 (Rifai strain KRL-AG2) under laboratory conditions...
  96. pmc Proteomic changes during intestinal cell maturation in vivo
    Jinsook Chang
    Center for Proteomics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Proteomics 71:530-46. 2008
    ..Three novel paneth cell markers, AGR2, HSPA5 and RRBP1 were also identified...
  97. ncbi Tunneling splitting of Jahn-Teller ions in oxides
    P Garcia-Fernandez
    Departamento de Ciencias de la Tierra y Fisica de la Materia Condensada, Universidad de Cantabria, Avenida de los Castros s n 39005 Santander, Spain
    Phys Rev Lett 104:035901. 2010
    ..Values associated with Cu2+- and Ag2+-doped MgO are 2 orders of magnitude larger than those previously assumed and consistent with the existence of a ..
  98. ncbi Fabrication of luminescent silver doped PbS nanowires in polymer
    Swapan K Mandal
    Department of Physics, Visva Bharati, Santiniketan 731235, India
    J Nanosci Nanotechnol 11:10234-9. 2011
    ..76 mol%) indicating strong modification of the electronic states by magnetic silver ions. While Ag2+ centers at the substitutional lattice site show an emission band around 525 nm, Ag0 at the interstitial site act ..
  99. doi Purification and characterization of a thermostable α-galactosidase from Thielavia terrestris NRRL 8126 in solid state fermentation
    Rawia R Saad
    Biological and Geological Sciences Department, Faculty of Education Ain Shams University, Heliopolis, Roxy, Cairo Egypt
    Acta Biol Hung 63:138-50. 2012
    ..Km of the purified enzyme was 1.31 mM. The purified enzyme was inhibited by Ag2+, Hg2+, Zn2+, Ba2+, Mg2+, Mn2+ and Fe2+ at 5 mM and 10 mM...
  100. pmc "Prostate cancer proteomics" database
    S S Shishkin
    Bach Institute of Biochemistry, Russian Academy of Sciences
    Acta Naturae 2:95-104. 2010
    ..PCP contains data on 359 proteins in total, including 17 potential biomarkers of prostate cancer, particularly AGR2, annexins, S100 proteins, PRO2675, and PRO2044...
  101. pmc Immunohistochemical panel for distinguishing esophageal adenocarcinoma from squamous cell carcinoma: a combination of p63, cytokeratin 5/6, MUC5AC, and anterior gradient homolog 2 allows optimal subtyping
    Michael A DiMaio
    Department of Pathology, Stanford University, Stanford, CA 94305, USA
    Hum Pathol 43:1799-807. 2012
    ..markers (p63, cytokeratin 5/6, cytokeratin 7, CDX2, MUC2, and MUC5AC) and 2 new markers, anterior gradient homolog 2 and SOX2, in esophageal carcinomas to establish the best panel to distinguish these tumors...

Research Grants15

  1. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..to express SPDEF and/or FOXA3 (using lentiviral vectors) and two distinct SPDEF target gene expression cassettes (Agr2-luciferase and Muc5A/C-renilla)...
  2. Steven M Lipkin; Fiscal Year: 2015
    ..Protein disulfide isomerases repair misfolded proteins and reduce ER stress. Anterior Gradient 2 (AGR2) is a protein disulfide isomerase expressed in intestinal secretory cells and macrophages...
  3. Airway Epithelial Responses to Allergic Inflammation
    David J Erle; Fiscal Year: 2010
    ..The other IL-13-induced gene encodes the goblet cell-specific secreted protein anterior gradient 2 (AGR2), which is a member of a family of proteins involved in cell adhesion and migration and in differentiation of mucus ..
  4. Novel Molecules in Airway Epithelial Endoplasmic Reticulum
    Bradley W Schroeder; Fiscal Year: 2012
    ..Previous trainees in the Erle lab have shown that AGR2, a novel member of the protein disulfide isomerase (PDI) family, plays a selective role in mucus production in vivo...
  5. Specialized molecules with essential roles in mucus production
    David J Erle; Fiscal Year: 2013
    ..We recently discovered that the protein anterior gradient homolog 2 (AGR2) plays an essential role in mucus production...
  6. Alvin Y Liu; Fiscal Year: 2015
    ..Second, tumor upregulated genes encoding extracellular/secreted proteins are selected. The gene AGR2 showed a comparatively high level of expression in prostate cancer cells, and the 17-kDa AGR2 protein was detected ..
  7. Caitlin C O'Meara; Fiscal Year: 2015
    ..Futhermore, nerve-dependent limb regeneration in the newt is partially mediated by the secreted protein Agr2. As in the newt limb, our preliminary data demonstrates that Agr2 can partially rescue cardiac regeneration in ..
  8. The Role of AGR2 in a Murine Model of Pancreatic Adenocarcinoma
    Anson W Lowe; Fiscal Year: 2012
    ..Effective therapies currently do not exist. This application is based on the hypothesis that the AGR2 gene is essential for the formation or propagation of pancreatic cancer, and proposes to test the AGR2 gene's ..
  9. CELLULAR ASSEMBLY AND TRANSPORT OF THE IGE RECEPTOR
    Michael Robertson; Fiscal Year: 2004
    ..events occur during FceRI ct-chain biosynthesis that profoundly influence the formation of a transport competent ag2 receptor: (i) glycosidase-mediated processing of a-chain core oligosaccharides in the ER and; (ii) the association ..
  10. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
  11. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
  12. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. Molecular Cloning of the Wilms tumor Gene from 7p15-21
    Khalid Sossey Alaoui; Fiscal Year: 2004
    ..Understanding the nature of the genetic events which allow these cells to escape their normal growth regulation may also provide an opportunity for therapeutic intervention. ..
  14. Regulation of the baboon HLA-G-like class Ib MHC gene, Paan-AG
    DAUDI LANGAT; Fiscal Year: 2008
    ..Thus the baboon is clearly an excellent model for HLA-G functional experiments, and testing the therapeutic applications of HLA-G in human pregnancy and transplantation. [unreadable] [unreadable] [unreadable] [unreadable]..
  15. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..