AGER

Summary

Gene Symbol: AGER
Description: advanced glycosylation end-product specific receptor
Alias: RAGE, SCARJ1, advanced glycosylation end product-specific receptor, RAGE isoform NtRAGE-delta, RAGE isoform sRAGE-delta, receptor for advanced glycation end-products variant 20
Species: human

Top Publications

  1. pmc Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE-/- mice
    Evis Harja
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 118:183-94. 2008
  2. doi RAGE regulates BACE1 and Abeta generation via NFAT1 activation in Alzheimer's disease animal model
    H J Cho
    Department of Biochemistry and Biomedical Sciences, Seoul National University College of Medicine, 28 Yungun Dong, Jongro Gu, Seoul, 110 799, Korea
    FASEB J 23:2639-49. 2009
  3. ncbi RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides
    M A Hofmann
    College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cell 97:889-901. 1999
  4. pmc RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease
    Fang Fang
    P and S 17 410, Department Surgery, College of Physicians and Surgeons, Columbia University, 630 West 168th St, New York, NY 10032, USA
    FASEB J 24:1043-55. 2010
  5. pmc The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosi
    T Miyata
    Department of Internal Medicine, Branch Hospital, Nagoya University School of Medicine, Japan
    J Clin Invest 98:1088-94. 1996
  6. ncbi Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system
    Shirley ShiDu Yan
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Nat Med 9:287-93. 2003
  7. pmc Genome-wide association study identifies five loci associated with lung function
    Emmanouela Repapi
    Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK
    Nat Genet 42:36-44. 2010
  8. ncbi Soluble receptor of advanced glycated endproducts is associated with plaque vulnerability in patients with acute myocardial infarction
    Hun Jun Park
    Department of Cardiology, College of Medicine, Seoul St Mary s Hospital, The Catholic University of Korea, Seoul, Korea
    Circ J 75:1685-90. 2011
  9. ncbi Associations of -374T/A polymorphism of receptor for advanced glycation end products (RAGE) gene in Turkish diabetic and non-diabetic patients with coronary artery disease
    Ozlem Kucukhuseyin
    The Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul University, Capa, 34390 Istanbul, Turkey
    In Vivo 23:949-54. 2009
  10. doi Role of advanced glycation end product receptors in the pathogenesis of diabetic retinopathy
    Hala O Al-Mesallamy
    Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
    J Diabetes Complications 25:168-74. 2011

Research Grants

  1. Novel Therapy for Diabetic Complications Using RAGE-Fc
    JAMES LARRICK; Fiscal Year: 2009
  2. Role and Mechanisms of Epithelial Injury in Diabetic Nephropathy
    Erwin P Bottinger; Fiscal Year: 2010
  3. Advanced Glycation End-Products in Human Myocardium
    Martin M LeWinter; Fiscal Year: 2011
  4. Novel Glycosaminoglycan Derivatives for Treatment of Bladder Inflammation
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
  5. Defective Membrane Repair in Diabetes
    Paul L McNeil; Fiscal Year: 2012
  6. Irina A Buhimschi; Fiscal Year: 2014
  7. Ulka Sachdev; Fiscal Year: 2016
  8. The role of innate immunity in idiopathic pulmonary arterial hypertension
    Philip M Bauer; Fiscal Year: 2012
  9. Lynne L Johnson; Fiscal Year: 2014
  10. Novel Models of Diabetic Nephropathy
    Moshe Levi; Fiscal Year: 2010

Detail Information

Publications309 found, 100 shown here

  1. pmc Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE-/- mice
    Evis Harja
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 118:183-94. 2008
    ..These inflammatory cells release receptor for advanced glycation endproduct (RAGE) ligands, specifically S100/calgranulins and high-mobility group box 1, which sustain vascular injury...
  2. doi RAGE regulates BACE1 and Abeta generation via NFAT1 activation in Alzheimer's disease animal model
    H J Cho
    Department of Biochemistry and Biomedical Sciences, Seoul National University College of Medicine, 28 Yungun Dong, Jongro Gu, Seoul, 110 799, Korea
    FASEB J 23:2639-49. 2009
    The receptor for advanced glycation end products (RAGE) is a multiligand cell surface receptor, and amyloid beta peptide (Abeta) is one of the ligands for RAGE...
  3. ncbi RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides
    M A Hofmann
    College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cell 97:889-901. 1999
    ..We report here that receptor for AGE (RAGE) is a central cell surface receptor for EN-RAGE (extracellular newly identified RAGE-binding protein) and related ..
  4. pmc RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease
    Fang Fang
    P and S 17 410, Department Surgery, College of Physicians and Surgeons, Columbia University, 630 West 168th St, New York, NY 10032, USA
    FASEB J 24:1043-55. 2010
    ..We demonstrate that overexpression of receptor for advanced glycation end products (RAGE) in imbroglio exaggerates neuroinflammation, as evidenced by increased proinflammatory mediator production, Abeta ..
  5. pmc The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosi
    T Miyata
    Department of Internal Medicine, Branch Hospital, Nagoya University School of Medicine, Japan
    J Clin Invest 98:1088-94. 1996
    ..of the inflammatory arthropathy of dialysis-related amyloidosis, is mediated by the receptor for AGEs, or RAGE. 125I-AGE-beta2M bound to immobilized RAGE or to MPs in a specific, dose-dependent manner (Kd approximately 53...
  6. ncbi Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system
    Shirley ShiDu Yan
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Nat Med 9:287-93. 2003
    ..The receptor for advanced glycation end products (RAGE) is present on T cells, mononuclear phagocytes and endothelium...
  7. pmc Genome-wide association study identifies five loci associated with lung function
    Emmanouela Repapi
    Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK
    Nat Genet 42:36-44. 2010
    ..11 x 10(-12)), 4q24 in GSTCD (2.18 x 10(-23)), 5q33 in HTR4 (P = 4.29 x 10(-9)), 6p21 in AGER (P = 3.07 x 10(-15)) and 15q23 in THSD4 (P = 7.24 x 10(-15))...
  8. ncbi Soluble receptor of advanced glycated endproducts is associated with plaque vulnerability in patients with acute myocardial infarction
    Hun Jun Park
    Department of Cardiology, College of Medicine, Seoul St Mary s Hospital, The Catholic University of Korea, Seoul, Korea
    Circ J 75:1685-90. 2011
    ..The roles of soluble and endogenous secretory receptors for advanced glycation endproducts (sRAGE and esRAGE, respectively) in plaque vulnerability are unknown in patients with acute myocardial infarction (AMI)...
  9. ncbi Associations of -374T/A polymorphism of receptor for advanced glycation end products (RAGE) gene in Turkish diabetic and non-diabetic patients with coronary artery disease
    Ozlem Kucukhuseyin
    The Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul University, Capa, 34390 Istanbul, Turkey
    In Vivo 23:949-54. 2009
    ..of coronary artery disease (CAD) in diabetic (DM(+)) and non-diabetic (DM(-)) patients according to the -374T/A polymorphism of the receptor for advanced glycation end products (RAGE) gene which affects the function of RAGE itself.
  10. doi Role of advanced glycation end product receptors in the pathogenesis of diabetic retinopathy
    Hala O Al-Mesallamy
    Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
    J Diabetes Complications 25:168-74. 2011
    Advanced glycation end products (AGEs) and the interaction with their receptors (RAGE) play an important role in the pathogenesis of diabetic retinopathy (DR)...
  11. pmc Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy
    Suganthalakshmi Balasubbu
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, MD, USA
    BMC Med Genet 11:158. 2010
    ..The aim of this study is to investigate the association of a set of nine candidate genes with the development of diabetic retinopathy in a South Indian cohort who have type 2 diabetes mellitus (T2DM)...
  12. ncbi Enhanced expression of receptor for advanced glycation end products in chronic kidney disease
    Fan Fan Hou
    Division of Nephrology, Nanfang Hospital, Guangzhou, People s Republic of China
    J Am Soc Nephrol 15:1889-96. 2004
    ..AGE) accumulate in CKD, but it is unclear if they stimulate monocytes by binding with the receptor for AGE (RAGE)...
  13. doi Effects of exercise on sRAGE levels and cardiometabolic risk factors in patients with type 2 diabetes: a randomized controlled trial
    Kyung Mook Choi
    Department of Internal Medicine, College of Medicine, Korea University, and Department of Internal Medicine, Diabetes Center, Eulji Hospital, Seoul, Korea
    J Clin Endocrinol Metab 97:3751-8. 2012
    ..Low levels of soluble receptor for advanced glycation end-products (sRAGE) have been linked to systemic inflammation and vascular complications in patients with type 2 diabetes mellitus (T2DM)...
  14. pmc The extracellular region of the receptor for advanced glycation end products is composed of two independent structural units
    Brian M Dattilo
    Department of Biochemistry, Center for Structural Biology, 465 21st Avenue South, 5140 BIOSCI MRBIII, Vanderbilt University, Nashville, Tennessee 37232 8725, USA
    Biochemistry 46:6957-70. 2007
    The receptor for advanced glycation end products (RAGE) is an important cell surface receptor being pursued as a therapeutic target because it has been implicated in complications arising from diabetes and chronic inflammatory conditions...
  15. doi Association between the RAGE G82S polymorphism and Alzheimer's disease
    Keshen Li
    Department of Neurology, Affiliated Hospital of Guangdong Medical College, 524001, Zhanjiang, China
    J Neural Transm (Vienna) 117:97-104. 2010
    The receptor for advanced glycation end products (RAGE) is associated with several pathological states including Alzheimer's disease (AD) pathology, while its soluble form (sRAGE) acts as a decoy receptor...
  16. doi Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity
    Ayumi Yoshizaki
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    J Clin Immunol 29:180-9. 2009
    The high mobility group box 1 protein (HMGB-1)/advanced glycation end products (RAGE) system is recently shown to play an important part in immune/inflammatory disorders...
  17. doi Association of polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating RAGE levels
    Katrien H J Gaens
    Department of Internal Medicine, Maastricht University Medical Center, Debeyelaan 25, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Clin Endocrinol Metab 94:5174-80. 2009
    The receptor for advanced glycation end products (RAGE)-ligand interaction has been linked to vascular complications...
  18. doi Association of polymorphisms in the RAGE gene with serum CRP levels and coronary artery disease in the Chinese Han population
    Jinxiong Gao
    Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China
    J Hum Genet 55:668-75. 2010
    The role of an advanced glycation end product/receptor for advanced glycation end product (AGE/RAGE) system in the pathogenesis of coronary artery disease (CAD) is not fully understood...
  19. doi Age of onset of myocardial infarction: is promoter polymorphism of the RAGE gene implicated?
    Chiara Boiocchi
    Interdipartimental Center for Research in Molecular Medicine CIRMC, University of Pavia, Pavia, Italy
    Rejuvenation Res 14:67-73. 2011
    Receptor for advanced glycation endproducts (RAGE) is a cell-surface molecule member of the immunoglobulin superfamily and engages differing ligands relevant to distinct processes...
  20. pmc RAGE-dependent activation of the oncoprotein Pim1 plays a critical role in systemic vascular remodeling processes
    Jolyane Meloche
    Department of Medicine, Universite Laval, Quebec City, Canada
    Arterioscler Thromb Vasc Biol 31:2114-24. 2011
    ..Recently, the activation of the advanced glycation endproducts receptor (RAGE) has been shown to promote VSMC proliferation and resistance to apoptosis in VRD in a signal transducer and ..
  21. pmc Association of the RAGE G82S polymorphism with Alzheimer's disease
    Jonny Daborg
    Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 432, 405 30, Gothenburg, Sweden
    J Neural Transm (Vienna) 117:861-7. 2010
    The receptor for advanced glycation end-products (RAGE) has been implicated in several pathophysiological processes relevant to Alzheimer's disease (AD), including transport and synaptotoxicity of AD-associated amyloid beta (Abeta) ..
  22. pmc The Receptor for Advanced Glycation End-products (RAGE) protects pancreatic tumor cells against oxidative injury
    Rui Kang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Antioxid Redox Signal 15:2175-84. 2011
    ..we investigated the effect of oxidative stress on activation of the Receptor for Advanced Glycation End-products (RAGE) and subsequent protection against H(2)O(2)-induced pancreatic tumor cell damage...
  23. pmc Homodimerization is essential for the receptor for advanced glycation end products (RAGE)-mediated signal transduction
    Hongliang Zong
    Centre for Vision and Vascular Science, Queen s University Belfast, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland, United Kingdom
    J Biol Chem 285:23137-46. 2010
    The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor that binds to diverse ligands and initiates a downstream proinflammatory signaling cascade...
  24. pmc Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications
    Ravichandran Ramasamy
    Diabetes Research Program, Division of Endocrinology, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    Ann N Y Acad Sci 1243:88-102. 2011
    The receptor for advanced glycation endproducts (RAGE) was first described as a signal transduction receptor for advanced glycation endproducts (AGEs), the products of nonenzymatic glycation and oxidation of proteins and lipids that ..
  25. pmc S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway
    Saeid Ghavami
    Manitoba Institute of Cell Biology and Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada
    J Leukoc Biol 83:1484-92. 2008
    ..Receptor of advanced glycation end product (RAGE) gene silencing and cotreatment with a RAGE-specific blocking antibody revealed that this activity was mediated via ..
  26. pmc Meta-analysis of RAGE gene polymorphism and coronary heart disease risk
    Jun Wang
    Department of Cardiothoracic Surgery, Changhai Hospital, Second Medical University, Shanghai, People s Republic of China
    PLoS ONE 7:e50790. 2012
    ..and animal studies have shown an upregulated expression of advanced glycosylation end product-specific receptor (RAGE) in human atherosclerotic plaques 1 and in retina, messangial, and aortic vessels, suggesting an important role of ..
  27. ncbi Plasma sRAGE is independently associated with urinary albumin excretion in type 2 diabetes
    Per M Humpert
    Department of Medicine 1, University of Heidelberg, Heidelberg, Germany
    Diabetes Care 29:1111-3. 2006
  28. doi The functional -374T/A polymorphism of the receptor for advanced glycation end products may modulate Crohn's disease
    Jan Däbritz
    Dept of General Pediatrics, Univ Children s Hospital Muenster, Munster, Germany
    Am J Physiol Gastrointest Liver Physiol 300:G823-32. 2011
    The receptor for advanced glycation end products (RAGE) is involved in innate immune mechanisms...
  29. ncbi Endogenous secretory receptor for advanced glycation endproducts as a novel prognostic marker in chondrosarcoma
    Akihiko Takeuchi
    Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Cancer 109:2532-40. 2007
    ..The receptor for advanced glycation endproducts (RAGE) and its ligand, high-mobility group box-1 (HMGB1), was quantified in enchondromas and chondrosarcomas to determine ..
  30. ncbi S100B and S100A6 differentially modulate cell survival by interacting with distinct RAGE (receptor for advanced glycation end products) immunoglobulin domains
    Estelle Leclerc
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland
    J Biol Chem 282:31317-31. 2007
    ..Experimental results suggest that the receptor for advanced glycation end products (RAGE) plays important roles in mediating S100 protein-induced cellular signaling...
  31. ncbi RAGE expression and AGE-induced MAP kinase activation in Caco-2 cells
    H Zill
    Institute of Human Nutrition and Food Science, University of Kiel, Duesternbrooker Weg 17, D 24105 Kiel, Germany
    Biochem Biophys Res Commun 288:1108-11. 2001
    b>RAGE (receptor for advanced glycation end products) is a multiligand cell surface molecule of the immunoglobulin superfamily...
  32. ncbi Receptor for advanced glycation end products plays a more important role in cellular survival than in neurite outgrowth during retinoic acid-induced differentiation of neuroblastoma cells
    Gangadharan Sajithlal
    Department of Neuroimmunological Cell Biology, Interdisziplinäres Zentrum für Klinische Forschung, University of Leipzig, Johannisallee 30a, Leipzig 04103, Germany
    J Biol Chem 277:6888-97. 2002
    The receptor for advanced glycation end products (RAGE), a member of the immunoglobulin superfamily, is known to interact with amphoterin...
  33. doi A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)
    Angela Raucci
    San Raffaele Scientific Institute, Milan, Italy
    FASEB J 22:3716-27. 2008
    The receptor for advanced glycation endproducts (RAGE) mediates responses to cell danger and stress...
  34. doi Cloning, characterisation, and comparative quantitative expression analyses of receptor for advanced glycation end products (RAGE) transcript forms
    Katharina A Sterenczak
    Small Animal Clinic and Research Cluster of Excellence REBIRTH, University of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Gene 434:35-42. 2009
    b>RAGE is a member of the immunoglobulin superfamily of cell surface molecules playing key roles in pathophysiological processes, e.g. immune/inflammatory disorders, Alzheimer's disease, diabetic arteriosclerosis and tumourigenesis...
  35. doi Minimum stable structure of the receptor for advanced glycation end product possesses multi ligand binding ability
    M Kumano-Kuramochi
    National Food Research Institute, 2 1 12 Kannondai, Tsukuba, Ibaraki 305 8642, Japan
    Biochem Biophys Res Commun 386:130-4. 2009
    The receptor for advanced glycation end products (RAGE) is a multi-ligand receptor involved in the development of diabetic complications...
  36. pmc Receptor for advanced glycation endproducts mediates pro-atherogenic responses to periodontal infection in vascular endothelial cells
    Andreas Pollreisz
    Division of Periodontics, College of Dental Medicine, Columbia University, 630 W 168th Street, PH7E 110, New York, NY, United States
    Atherosclerosis 212:451-6. 2010
    ..The receptor for advanced glycation endproducts (RAGE) regulates vascular inflammation and atherogenesis. We hypothesized that RAGE is involved in P...
  37. doi Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-α production in a receptor for advanced glycation end product-dependent manner
    Benfang Helen Ruan
    Inflammation and Immunology, Pfizer BioTherapeutics Research and Development, Cambridge, MA 02140, USA
    J Immunol 185:4213-22. 2010
    The receptor for advanced glycation end products (RAGE) is a multiligand transmembrane receptor implicated in a number of diseases including autoimmune diseases...
  38. ncbi [Expression of RECK, RAGE and MMP-9 in nasopharyngeal carcinoma and its significance]
    Ronghua Li
    Department of Otolaryngology, The Teaching Hospital of Fujian Medical University, Zhongshan Hospital of Xiamen University, Xiamen, 361004, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 24:823-7. 2010
    To investigate the expression and the relativity of RECK,RAGE and MMP-9 in nasopharyngeal carcinoma (NPC) tissues.
  39. doi The receptor for advanced glycation endproducts and its ligands in patients with myasthenia gravis
    Bernhard Moser
    Department of Thoracic Surgery, Division of Surgery, Medical University Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Biochem Biophys Res Commun 420:96-101. 2012
    ..The receptor for advanced glycation endproducts (RAGE) plays a role in the amplification of chronic inflammatory disorders and autoimmune diseases...
  40. pmc RAGE genetic polymorphisms are associated with risk, chemotherapy response and prognosis in patients with advanced NSCLC
    Xiang Wang
    Huzhou Central Hospital, Huzhou, Zhejiang, China
    PLoS ONE 7:e43734. 2012
    To explore the association between genetic polymorphisms of the receptor for advanced glycation end-products (RAGE) and susceptibility, chemotherapy response rate and prognosis of non-small cell lung cancer (NSCLC).
  41. doi Immunohistochemical expression of RAGE and its ligand (S100A9) in cervical lesions
    Xuejie Zhu
    Department of Obstetrics and Gynecology, First Affiliated Hospital of Wenzhou Medical College, Wenzhou, People s Republic of China
    Cell Biochem Biophys 66:843-50. 2013
    Altered expressions of receptor for advanced glycation end-products (RAGE) and its ligand (S100A9) are observed in many cancers and play a key role in inflammation-associated cancer...
  42. ncbi Clinical significance of immunogenic cell death biomarker rage and early growth response 1 in human primary gastric adenocarcinoma
    X C Xu
    Department of Gastrointestinal Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China
    Int J Immunopathol Pharmacol 26:485-93. 2013
    The receptor for advanced glycation end products (RAGE), a pattern recognition receptor that binds multiple ligands derived from a damaged cell environment, contributes to multiple pathologies including cancer...
  43. doi The -374T/A RAGE polymorphism protects against future cardiac events in nondiabetic patients with coronary artery disease
    Colomba Falcone
    Department of Cardiology, University Hospital Fondazione IRCCS San Matteo, Pavia, Italy Interdepartmental Center for Research in Prevention of Cardiovascular and Metabolic Disorders CIRMC, University of Pavia, Pavia, Italy
    Arch Med Res 39:320-5. 2008
    The -374T/A polymorphism of the Receptor for Advanced Glycation End products (RAGE) may exert a protective effect toward the development of atherosclerosis...
  44. ncbi Association study of G1704T and G82S polymorphisms of RAGE gene for microalbuminuria in Japanese type 2 diabetic patients
    Keiji Yoshioka
    Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, Moriguchi, Osaka, Japan
    Metabolism 54:488-91. 2005
    To clarify whether polymorphisms G1704T and G82S of the RAGE gene were related to microalbuminuria, we performed a case-control study in Japanese type 2 diabetic patients...
  45. doi Association between sRAGE, esRAGE levels and vascular inflammation: analysis with (18)F-fluorodeoxyglucose positron emission tomography
    Sae Jeong Yang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea
    Atherosclerosis 220:402-6. 2012
    The receptor for advanced glycation end-products (RAGE) and its diverse ligands play a pivotal role in the development of cardiovascular disease...
  46. ncbi The -374A allele of the RAGE gene as a potential protective factor for vascular complications in type 2 diabetes: a meta-analysis
    Weixin Lu
    Department of Endocrinology, Shanghai East Hospital, Tongji University, Shanghai, P R China
    Tohoku J Exp Med 220:291-7. 2010
    The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily and may be involved in the development of diabetic vascular complications...
  47. ncbi Receptor for advanced glycation end product polymorphisms and type 2 diabetes: the CODAM study
    Katrien H J Gaens
    Department of Internal Medicine, Laboratory for Metabolism and Vascular Medicine, Maastricht University, Maastricht, The Netherlands
    Ann N Y Acad Sci 1126:162-5. 2008
    Genetic variation in the receptor for advanced glycation end products (RAGE) gene may alter the expression and function of RAGE and affect disease development and outcome...
  48. doi Proteomic studies on receptor for advanced glycation end product variants in idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease
    Steffen Ohlmeier
    Biocenter Oulu, Department of Biochemistry, University of Oulu, Finland
    Proteomics Clin Appl 4:97-105. 2010
    Proteomic screening revealed declined levels of the receptor for advanced glycation end products (RAGE) in human idiopathic pulmonary fibrosis (IPF)...
  49. doi A meta-analysis of receptor for advanced glycation end products gene: four well-evaluated polymorphisms with diabetes mellitus
    WenQuan Niu
    State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Mol Cell Endocrinol 358:9-17. 2012
    Genetic association studies on the gene encoding receptor for advanced glycation end products (RAGE) and diabetes mellitus have reported conflicting results...
  50. pmc Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease
    Miles C Miller
    Division of Neuropathology, Department of Pathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, 593 Eddy Street APC 12 219, Providence, RI 02903, USA
    Brain Res 1230:273-80. 2008
    ..In this study, we examined the receptor for advanced glycation endproducts (RAGE), a multi-ligand receptor found in both neurons and cerebral microvascular endothelia that binds Abeta...
  51. ncbi RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease
    S D Yan
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York 10032, USA
    Nature 382:685-91. 1996
    ..Here we present evidence that the 'receptor for advanced glycation end products' (RAGE) is such a receptor, and that it mediates effects of the peptide on neurons and microglia...
  52. pmc Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury
    Hideto Yonekura
    Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science, Kanazawa 920 8640, Japan
    Biochem J 370:1097-109. 2003
    The binding of advanced glycation end-products (AGE) to the receptor for AGE (RAGE) is known to deteriorate various cell functions and is implicated in the pathogenesis of diabetic vascular complications...
  53. doi Associations of receptor for advanced glycation end products -374 T/A and Gly82 Ser and peroxisome proliferator-activated receptor gamma Pro12Ala polymorphisms in Turkish coronary artery disease patients
    Hulya Yilmaz Aydogan
    Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
    Genet Test Mol Biomarkers 16:134-7. 2012
    ..study was to investigate the individual and combined effects of receptor for advanced glycation end products (RAGE) -374T/A, RAGE Gly82Ser, and peroxisome proliferator-activated receptor gamma (PPAR-γ) Pro12Ala polymorphisms on ..
  54. ncbi Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy
    B I Hudson
    Academic Unit of Molecular Vascular Medicine, Research School of Medicine, Leeds General Infirmary, University of Leeds, Leeds, LS1 3EX, U K
    Diabetes 50:1505-11. 2001
    Interactions between advanced glycation end products (AGEs) and the receptor for AGE (RAGE) are implicated in the vascular complications in diabetes...
  55. ncbi Expression analysis of S100 proteins and RAGE in human tumors using tissue microarrays
    Hsiao Ling Hsieh
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Switzerland
    Biochem Biophys Res Commun 307:375-81. 2003
    ..Interestingly, expression of RAGE (receptor for advanced glycation end products) was found in breast and lung tumor tissues where abundant S100A4 and ..
  56. doi Calcium-regulated intramembrane proteolysis of the RAGE receptor
    Arnaud Galichet
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland
    Biochem Biophys Res Commun 370:1-5. 2008
    The receptor for advanced glycation endproducts (RAGE) interacts with several ligands and is involved in various human diseases. RAGE_v1 or sRAGE, a RAGE splice variant, is secreted and contributes to the removal of RAGE ligands...
  57. pmc Higher plasma soluble Receptor for Advanced Glycation End Products (sRAGE) levels are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-year follow-up study
    Johanna W M Nin
    Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    Diabetes 59:2027-32. 2010
    ....
  58. pmc Advanced glycation end products and their circulating receptors and level of kidney function in older community-dwelling women
    Richard D Semba
    Johns Hopkins Medical Institutions, 550 N Broadway, Baltimore, MD 21205, USA
    Am J Kidney Dis 53:51-8. 2009
    Advanced glycation end products (AGEs) and the receptor for AGE (RAGE) are implicated in the pathogenesis of kidney disease; however, their relation with level of kidney function has not been well characterized.
  59. ncbi N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression
    T Kislinger
    College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 274:31740-9. 1999
    ..the interaction of advanced glycation end products (AGEs), with the signal-transducing receptor receptor for AGE (RAGE), by administration of the soluble, extracellular ligand-binding domain of RAGE, reversed vascular ..
  60. ncbi Co-expression of receptor for advanced glycation end products and the ligand amphoterin associates closely with metastasis of colorectal cancer
    Hiroki Kuniyasu
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashihara, Japan
    Oncol Rep 10:445-8. 2003
    The clinical relevance of the receptor for advanced glycation end products (RAGE) and amphoterin expression was examined in 119 non-diabetic patients with colorectal carcinoma...
  61. ncbi The functional -374 T/A RAGE gene polymorphism is associated with proteinuria and cardiovascular disease in type 1 diabetic patients
    Kim Pettersson-Fernholm
    Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, Helsinki, Finland
    Diabetes 52:891-4. 2003
    ..end products (AGEs) that predominantly act through specific receptors, particularly the receptor for AGEs (RAGE)...
  62. ncbi Regulation of cyclooxygenase-2 expression in monocytes by ligation of the receptor for advanced glycation end products
    Narkunaraja Shanmugam
    Gonda Diabetes Research Center, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    J Biol Chem 278:34834-44. 2003
    ..Advanced glycation end products (AGEs) act via their receptor, RAGE, to play a major role in diabetic complications...
  63. pmc Increased expression of tissue factor and receptor for advanced glycation end products in peripheral blood mononuclear cells of patients with type 2 diabetes mellitus with vascular complications
    A E Buchs
    Diabetes Unit, Internal Medicine C, Assaf Harofeh Medical Center, Zerifin, Israel
    Exp Diabesity Res 5:163-9. 2004
    ..TF and RAGE mRNAs as well as TF antigen and activity were investigated in 21 T2D patients with and without vascular ..
  64. ncbi Down-regulation of the receptor for advanced glycation end-products (RAGE) supports non-small cell lung carcinoma
    Babett Bartling
    Clinic of Cardiothoracic Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06120 Halle Saale, Germany
    Carcinogenesis 26:293-301. 2005
    The receptor for advanced glycation end-products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily. Several ligands binding to RAGE have been identified, including amphoterin...
  65. ncbi Splice variants of the receptor for advanced glycosylation end products (RAGE) in human brain
    Qunxing Ding
    Department of Anatomy and Neurobiology, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536 0230, USA
    Neurosci Lett 373:67-72. 2005
    Previous studies indicate that the receptor for advanced glycosylation end products (RAGE) plays an important role in multiple pathological processes, including Alzheimer's disease...
  66. ncbi -374T/A polymorphism of the RAGE gene promoter in relation to severity of coronary atherosclerosis
    Colomba Falcone
    Department of Hematological, Pneumological and Cardiovascular Sciences, Division of Cardiology, University Hospital IRCCS Policlinico San Matteo, University of Pavia, Piazzale Golgi 2, 27100 Pavia, Italy
    Clin Chim Acta 354:111-6. 2005
    We have recently reported that homozygosity for the minor A-allele of RAGE (receptor for advanced glycation end products) -374T/A polymorphism may exert a protective effect toward the development of angiographic coronary artery disease (..
  67. ncbi Circulating levels of soluble receptor for advanced glycation end products in Alzheimer disease and vascular dementia
    Enzo Emanuele
    Molecular Medicine Laboratory, University of Pavia, IRCCS San Matteo Hospital, Pavia, Italy
    Arch Neurol 62:1734-6. 2005
    The receptor for advanced glycation end products (RAGE) is a cell surface receptor that has been implicated in vascular disease and neurodegeneration...
  68. ncbi Association between serum levels of soluble receptor for advanced glycation end products and circulating advanced glycation end products in type 2 diabetes
    K C B Tan
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, People s Republic of China
    Diabetologia 49:2756-62. 2006
    Activation of the receptor for advanced glycation end products (RAGE, also known as AGE-specific receptor [AGER]) has been implicated in the development of diabetic vascular complications...
  69. ncbi Elevation of soluble form of receptor for advanced glycation end products (sRAGE) in diabetic subjects with coronary artery disease
    Kazuo Nakamura
    Departments of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
    Diabetes Metab Res Rev 23:368-71. 2007
    Advanced glycation end products (AGEs)-receptor (RAGE) axis is implicated in diabetic vascular complication...
  70. pmc Hypochlorite-modified albumin colocalizes with RAGE in the artery wall and promotes MCP-1 expression via the RAGE-Erk1/2 MAP-kinase pathway
    Gunther Marsche
    Medical University of Graz, Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Harrachgasse 21, A 8010 Graz, Austria
    FASEB J 21:1145-52. 2007
    Signal transduction via the endothelial receptor for advanced glycation end products (RAGE) plays a key role in vascular inflammation...
  71. pmc Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes
    Per M Humpert
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Germany
    Cardiovasc Diabetol 6:9. 2007
    ..Since previous data were partly divergent, the aim of this study was to compare sRAGE and esRAGE in a head-to-head analysis in patients with type 2 diabetes (T2DM) with albuminuria...
  72. pmc Serum levels of sRAGE, the soluble form of receptor for advanced glycation end products, are associated with inflammatory markers in patients with type 2 diabetes
    Kazuo Nakamura
    Departments of Medicine, Kurume University School of Medicine, Kurume, Japan
    Mol Med 13:185-9. 2007
    Advanced glycation end products (AGEs) and their receptor (RAGE) play an important role in accelerated atherosclerosis in diabetes...
  73. ncbi Reduced expression of endogenous secretory receptor for advanced glycation endproducts in hippocampal neurons of Alzheimer's disease brains
    Ichiro Nozaki
    Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Arch Histol Cytol 70:279-90. 2007
    The receptor for advanced glycation endproducts (RAGE) is a cell-surface multiligand receptor, which interacts with amyloid beta (Abeta), a key protein in Alzheimer's disease (AD)...
  74. pmc Distinct roles of heterogeneous nuclear ribonuclear protein K and microRNA-16 in cyclooxygenase-2 RNA stability induced by S100b, a ligand of the receptor for advanced glycation end products
    Narkunaraja Shanmugam
    Division of Diabetes, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    J Biol Chem 283:36221-33. 2008
    Advanced glycation end products play major roles in diabetic complications. They act via their receptor RAGE to induce inflammatory genes such as cyclooxygenase-2 (COX-2)...
  75. ncbi Association of 1704G/T and G82S polymorphisms in the receptor for advanced glycation end products gene with diabetic retinopathy in Chinese population
    H M Zhang
    Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Endocrinol Invest 32:258-62. 2009
    The receptor for advanced glycation end products (RAGE) plays an important role in the pathogenesis of diabetic complications...
  76. ncbi Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3
    K Sugaya
    Department of Evolutionary Genetics, National Institute of Genetics, Shizuoka ken, Japan
    Genomics 23:408-19. 1994
    ..The gene for receptor of advanced glycosylation end products of proteins (RAGE, a member of immunoglobulin superfamily molecules), the PBX2 homeobox gene designated HOX12, and the human ..
  77. pmc Expression of receptors for advanced glycation end products in peripheral occlusive vascular disease
    U Ritthaler
    Department of Medicine, University of Heidelberg, Germany
    Am J Pathol 146:688-94. 1995
    ..occur, at least in part, through their binding to a novel integral membrane protein, the receptor for AGEs (RAGE)...
  78. ncbi Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways
    H J Huttunen
    Laboratory of Molecular Neurobiology, Institute of Biotechnology, and Department of Biosciences, Division of Biochemistry, University of Helsinki, Finland
    J Biol Chem 274:19919-24. 1999
    Receptor for advanced glycation end products (RAGE) mediates neurite outgrowth in vitro on amphoterin-coated substrates...
  79. ncbi Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis
    S D Yan
    Departments of Pathology, Physiology, and Surgery, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nat Med 6:643-51. 2000
    ..Here we show that RAGE, a multiligand immunoglobulin superfamily cell surface molecule, is a receptor for the amyloidogenic form of serum ..
  80. ncbi Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation
    H J Huttunen
    Programme of Molecular Neurobiology, Institute of Biotechnology, and the Department of Biosciences, University of Helsinki, Helsinki FIN 00014, Finland
    J Biol Chem 275:40096-105. 2000
    ..migration in embryonic neurons and in tumor cells through binding to receptor for advanced glycation end products (RAGE), a multiligand transmembrane receptor...
  81. ncbi A novel polymorphism in the promoter of the RAGE gene is associated with non-small cell lung cancer
    S Schenk
    Laboratory of Molecular Oncology, Department of Research, University Hospital Basel, Schanzenstrasse 46, CH 4031 Basel, Switzerland
    Lung Cancer 32:7-12. 2001
    The receptor for advanced glycosylation endproducts (RAGE) is abundant at both the transcriptional and translational level in normal lung but is not expressed in non-small cell lung cancer (NSCLC)...
  82. ncbi Expression of receptor for advanced glycation end products (RAGE) and MMP-9 in human pancreatic cancer cells
    Moriatsu Takada
    Department of Gastroenterological Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan
    Hepatogastroenterology 51:928-30. 2004
    ..and migration in tumor cells and embryonic neurons through binding to receptor for advanced glycation end products (RAGE), a multiligand cell surface molecule of the immunoglobulin superfamily...
  83. ncbi Thiazolidinediones reduce endothelial expression of receptors for advanced glycation end products
    Nikolaus Marx
    Department of Internal Medicine II Cardiology, University of Ulm, Robert Koch Str 8, D 89081 Ulm, Germany
    Diabetes 53:2662-8. 2004
    ..In animal models, interruption of the AGE-RAGE interaction reduces lesion size and plaque development...
  84. ncbi Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy
    Josephine M Forbes
    Address correspondence to Dr Josephine Forbes, Danielle Alberti Memorial Centre for Diabetes Complications, Baker Heart Research Institute, P O Box 6492, St Kilda Road, Melbourne, Victoria, 8008, Australia
    J Am Soc Nephrol 16:2363-72. 2005
    ..and human approaches to explore the potential effects of these agents on the modulation of the receptor for AGE (RAGE)...
  85. pmc Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis
    Richard F Loeser
    Rush Medical College, Chicago, IL 60612, USA
    Arthritis Rheum 52:2376-85. 2005
    The receptor for advanced glycation end products (RAGE) binds multiple ligands, including S100 proteins, high mobility group box chromosomal protein 1 (HMGB-1), and AGEs, all of which are present in articular cartilage...
  86. ncbi Association of expression of receptor for advanced glycation end products and invasive activity of oral squamous cell carcinoma
    Ujjal K Bhawal
    Department of Dental and Medical Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Oncology 69:246-55. 2005
    The receptor for advanced glycation end products (RAGE) is a newly recognized factor regulating cancer cell invasion and metastasis...
  87. ncbi Telmisartan inhibits expression of a receptor for advanced glycation end products (RAGE) in angiotensin-II-exposed endothelial cells and decreases serum levels of soluble RAGE in patients with essential hypertension
    Kazuo Nakamura
    Department of Internal Medicine III, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Microvasc Res 70:137-41. 2005
    There is a growing body of evidence that the advanced glycation end product (AGE)-their receptor (RAGE) system plays a central role in the pathogenesis of diabetic vascular complication...
  88. ncbi Association of RAGE gene polymorphisms with coronary artery disease in the Korean population
    Se Jung Yoon
    Division of Cardiology, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea
    Coron Artery Dis 18:1-8. 2007
    AGEs (advanced glycation end products)-RAGE (receptor for advanced glycation end products) interaction in vessel wall may lead to inflammation, smooth muscle cell proliferation and extracellular matrix production, culminating in ..
  89. ncbi Association of the Gly82Ser polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating levels of soluble RAGE and inflammatory markers in nondiabetic and nonobese Koreans
    Yangsoo Jang
    Division of Cardiology, Cardiovascular Genome Center, Yonsei Medical Institute, Yonsei University, Seoul, South Korea
    Metabolism 56:199-205. 2007
    ..the association between the Gly82Ser (G82S) polymorphism in the receptor for advanced glycation end products (RAGE) gene and circulating levels of soluble RAGE (sRAGE), advanced glycation end products (AGEs), and inflammatory ..
  90. pmc Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritis
    Lisa Carroll
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland 4102, Australia
    Arthritis Res Ther 9:R39. 2007
    ..The receptor for advanced glycation end products (RAGE) has been implicated in the perpetuation of the chronic inflammatory response in vascular disease...
  91. ncbi The -429 T>C polymorphism of the receptor for advanced glycation end products (RAGE) is associated with type 1 diabetes in a Brazilian population
    Geraldo Picheth
    Clin Chim Acta 383:163-4. 2007
  92. pmc RAGE expression in rhabdomyosarcoma cells results in myogenic differentiation and reduced proliferation, migration, invasiveness, and tumor growth
    Francesca Riuzzi
    Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, Via del Giochetto C P 81 Succ 3, 06122 Perugia, Italy
    Am J Pathol 171:947-61. 2007
    Activation of receptor for advanced glycation end products (RAGE) by its ligand, HMGB1, stimulates myogenesis via a Cdc42-Rac1-MKK6-p38 mitogen-activated protein kinase pathway...
  93. pmc Structural and functional insights into RAGE activation by multimeric S100B
    Thorsten Ostendorp
    Fachbereich Biologie, Mathematisch Naturwissenschaftliche Sektion, Universitat Konstanz, Konstanz, Germany
    EMBO J 26:3868-78. 2007
    ..In the extracellular space, it promotes neurite extension and neuron survival via the receptor RAGE (receptor for advanced glycation end products)...
  94. ncbi De-N-glycosylation or G82S mutation of RAGE sensitizes its interaction with advanced glycation endproducts
    Mari Osawa
    Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Biochim Biophys Acta 1770:1468-74. 2007
    Interactions between advanced glycation endproducts (AGE) and the receptor for AGE (RAGE) have been implicated in the development of diabetic vascular complications...
  95. pmc A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis
    Judson M Englert
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Pathol 172:583-91. 2008
    ..The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface receptors whose activation has been linked to ..
  96. doi Gly82Ser polymorphism of the receptor for advanced glycation end products is associated with an increased risk of gastric cancer in a Chinese population
    Haijuan Gu
    Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu Province, China
    Clin Cancer Res 14:3627-32. 2008
    It has been shown that the expression of the receptor for advanced glycation end products (RAGE) is closely associated with invasion and metastasis in gastric cancer...
  97. doi Circulating soluble receptor for advanced glycation end products is inversely associated with body mass index and waist/hip ratio in the general population
    Giuseppe Danilo Norata
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Nutr Metab Cardiovasc Dis 19:129-34. 2009
    Advanced glycation end products, AGEs, and its specific receptor, RAGE, are involved in vascular complications...
  98. doi Structural basis for pattern recognition by the receptor for advanced glycation end products (RAGE)
    Jingjing Xie
    Department of Chemistry State University of New York, Albany, New York 12222, USA
    J Biol Chem 283:27255-69. 2008
    The receptor for advanced glycated end products (RAGE) is a multiligand receptor that is implicated in the pathogenesis of various diseases, including diabetic complications, neurodegenerative disorders, and inflammatory responses...
  99. pmc RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
    Olga Turovskaya
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Carcinogenesis 29:2035-43. 2008
    ..We earlier showed that carboxylated N-glycans expressed on receptor for advanced glycation end products (RAGE) and other glycoproteins mediate colitis through activation of nuclear factor kappa B (NF-kappaB)...
  100. doi Severity of diabetic microvascular complications is associated with a low soluble RAGE level
    N Grossin
    Cellular and Vascular Biology, INTS, France
    Diabetes Metab 34:392-5. 2008
    The receptor for advanced glycation end-products (RAGE) has been implicated in diabetic microvascular complications, but several lines of evidence suggest that the soluble isoform of RAGE (sRAGE) may protect against AGE-mediated vessel ..
  101. pmc Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42
    Barry I Hudson
    Division of Surgical Science, Departments of Surgery and Pathology, Columbia University Medical Center, Columbia University, New York, New York, 10032, USA
    J Biol Chem 283:34457-68. 2008
    ..The receptor for advanced glycation end products (RAGE) is a multiligand cell surface macromolecule which binds distinct ligands that accumulate in these settings...

Research Grants65

  1. Novel Therapy for Diabetic Complications Using RAGE-Fc
    JAMES LARRICK; Fiscal Year: 2009
    Recent investigations demonstrate the importance of receptor for advanced glycation end products (RAGE) mediated signal transduction in promoting pathogenic inflammation, renal failure and diabetic complications...
  2. Role and Mechanisms of Epithelial Injury in Diabetic Nephropathy
    Erwin P Bottinger; Fiscal Year: 2010
    ..whether proximal tubular overexpression of AGE binding proteins CD36 and RAGE leads to increased tubular epithelial injury/apoptosis and tubulointerstitial progression of DN in mice
  3. Advanced Glycation End-Products in Human Myocardium
    Martin M LeWinter; Fiscal Year: 2011
    ..AGEs also increase collagen content by interacting with the receptor for AGEs (RAGE), which results in pro-fibrotic signaling mediated via nuclear transcription factor kappa B (NFKB) and downstream ..
  4. Novel Glycosaminoglycan Derivatives for Treatment of Bladder Inflammation
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..L-selectin binding, cationic protease activity, and activation of the receptor for advanced glycation end-products (RAGE)...
  5. Defective Membrane Repair in Diabetes
    Paul L McNeil; Fiscal Year: 2012
    ..surface and other proteins in diabetes, and AGE can become cross-linked to one another, or be bound by a receptor, RAGE (receptor for advanced glycation end-products)...
  6. Irina A Buhimschi; Fiscal Year: 2014
    ..become "danger signals" by activating endogenous receptors such as the receptor of advanced glycation end-products (RAGE)...
  7. Ulka Sachdev; Fiscal Year: 2016
    ..immunity, including Toll-like Receptors (TLR) 2 and 4, as well as the Receptor for Advanced Glycation End-products (RAGE)...
  8. The role of innate immunity in idiopathic pulmonary arterial hypertension
    Philip M Bauer; Fiscal Year: 2012
    ..receptors (PRRs) including Toll-Like Receptor 2 (TLR2), TLR4, and the Receptor for Advanced Glycation End Products (RAGE)...
  9. Lynne L Johnson; Fiscal Year: 2014
    ..smoke can stimulate inflammatory pathways by signaling through the receptor for advanced glycation end-products (RAGE), which binds a number of ligands that activate intracellular pathways, leading to release of inflammatory ..
  10. Novel Models of Diabetic Nephropathy
    Moshe Levi; Fiscal Year: 2010
    ..regulator of SREBP-1 and ChREBP expression as well as oxidative stress, advanced glycation end products (AGEs/RAGE), pro-inflammatory cytokines, and fibrosis inducing growth factors...
  11. John Morser; Fiscal Year: 2014
    ..interact directly with cells as well as antagonize signaling at the Receptor for Advanced Glycation End products (RAGE) by binding high mobility group protein B1 (HMGB1)...
  12. Ann Marie Schmidt; Fiscal Year: 2016
    ..In murine and human subjects, receptor for AGE (RAGE) expression is upregulated in vascular and immune cells in non-diabetic and diabetic atherosclerosis...
  13. RAGE-Proteolyzing Antibodies for Alzheimer's Disease Therapy
    PETER J HEINZELMAN; Fiscal Year: 2012
    ..many ligands is an attractive AD treatment strategy, toxicity, low efficacy and poor BBB penetration have limited RAGE-targeted therapeutic testing to one small molecule and even this lone drug candidate caused side effects...
  14. Advanced glycation end products and colorectal cancer risk in women
    Li Jiao; Fiscal Year: 2012
    ..AGEs trigger oxidative stress and inflammation by interacting with the receptor for AGEs (RAGE)...
  15. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..inhalation of AGES from tobacco products amplify inflammation by ligation of the cell-surface receptor for AGEs, or RAGE. Recently, RAGE-mediated inflammation has been implicated in periodontal inflammation and osteoclastogenic bone ..
  16. Behnam Badie; Fiscal Year: 2015
    ..protein that is highly expressed in astrocytomas, upregulated receptor for advanced glycation end products (RAGE, a S100B receptor), induced STAT3, and inhibited MG proinflammatory function in vitro...
  17. JUSTIN RODNEY SAVAGE; Fiscal Year: 2015
    ..of diabetes-related advanced glycation end-products (AGEs) with the receptor for advanced glycation end- products (RAGE) promotes accelerated periodontal inflammation...
  18. Gregory L Stahl; Fiscal Year: 2016
    ..leads to cardiac autophagy and represents a centralized nexus for pro-fibrotic mediator production including RAGE, TGF-21 and galectin- 3...
  19. LYNETTE KAY ROGERS; Fiscal Year: 2015
    ..Receptor for Advanced Glycation End Products (RAGE) is a "Damage Associated Molecular Pattern" receptor and, as such, is able to engage classes of unrelated molecules ..
  20. John R Hoidal; Fiscal Year: 2016
    ..Hypotheses: We propose a new paradigm for a central role of the receptor for advanced glycation end products (RAGE) and its ligands in the emphysema pathogenesis...
  21. KATHLEEN RAMAN; Fiscal Year: 2016
    ..Activation of the receptor for advanced glycation end products (RAGE) leads to both an acute inflammatory response and perpetuation of a chronic, sustained inflammatory state leading ..
  22. Li Jiao; Fiscal Year: 2015
    ..AGEs trigger and maintain insulin resistance and inflammation by interacting with the receptor for AGEs (RAGE)...
  23. Kathy K Griendling; Fiscal Year: 2016
    ..W. Robert Taylor will examine the overall role of the receptor for advanced glycation end products (RAGE) in inhibiting collateral vessel formation in normal and diabetic conditions, focusing on the specific ..
  24. DAVID PAUL TURNER; Fiscal Year: 2014
    ..to our hypothesis that "elevated levels of AGE's promote cancer disparity through the activation of the AGE-RAGE signaling axis to promote inflammation"...
  25. Eric P Skaar; Fiscal Year: 2016
    ..and is a known pro- inflammatory molecule that is a ligand for the receptor for advanced glycation end products (RAGE)...
  26. ESTHER AMALIA GUZMAN; Fiscal Year: 2014
    ..The receptor for advanced glycation end products (RAGE) has emerged as a potential chemotherapeutic target in pancreatic cancer...
  27. The Role of RAGE in Diabetes and Myocardial Infarction.
    KAREN O'SHEA; Fiscal Year: 2013
    ..studies by our laboratory have revealed a central role for the receptor for advanced glycation end-products (RAGE) in myocardial infarction, as global deletion of RAGE resulted in decreased myocardial necrosis, increased ..
  28. RAGE Mediated Mechanisms of Islet Amyloid Polypeptide Cytotoxicity in Type 2 Diab
    Andisheh Abedini; Fiscal Year: 2011
    ..Biochemical and physiological studies have shown that b-sheet containing amyloid precursors can bind and activate RAGE (receptor for advanced glycation end-products)...
  29. Mechanisms of intestinal failure in post-surgical inflammatory bowel disease
    PAULINE LUND; Fiscal Year: 2009
    ..also test if tissue damage associated pattern signals (DAMPS) or receptor for advanced glycosylation end products (RAGE) correlate with initiation or perpetuation of post-surgical inflammation or fibrosis...
  30. James M May; Fiscal Year: 2015
    ..of high glucose concentrations are caused by activation of the Receptor for Advanced Glycation End-products (RAGE), the third aim will test the mechanism by which ascorbic acid prevents increased endothelial permeability due to ..
  31. Aging and IGF-I in Cartilage
    RICHARD LOESER; Fiscal Year: 2009
    ..It has also been found that chondrocytes express RAGE (receptor for advanced glycation end-products)...
  32. Richard D Semba; Fiscal Year: 2016
    ..We also showed that advanced glycation end products (AGEs) and receptor for AGEs (RAGE) were independently associated with poor muscle strength, disability, and mortality...
  33. Advanced glycation end products in SLE: Lupus factor for Cardiovascular Disease?
    KATHLEEN M MAKSIMOWICZ-MCKINNON; Fiscal Year: 2012
    ..Attaining the stated Specific Aims will advance our understanding of the interactions between inflammation and complement activation and their role in CVD in SLE. ..
  34. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2010
    ..characterize and identify the complement components involved in the expression of pro-fibrotic mediators, including RAGE, TGF-21 and galectin-3...
  35. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..the age-modified expression of the Ap transporters, LRP-1 and the receptor for advanced glycation end products (RAGE), in CP and BBB, as the CSF system continually deteriorates...
  36. Novel Glycosaminoglycan Ethers for Prevention of Metastasis
    Alana L Welm; Fiscal Year: 2011
    ..adhesion receptor P-selectin and inhibition of the interaction of the Receptor for Advanced Glycation End-products (RAGE) with its many ligands...
  37. Michael R Zile; Fiscal Year: 2014
    ..that the formation of advanced glycation end products (AGEs) and their interaction with the receptor for AGEs (RAGE) are a primary determinants of myocardial stiffness, collagen structure and fibroblast phenotype...
  38. Maria G Castro; Fiscal Year: 2015
    ..that GBM cells in vitro and in vivo express ligands for the receptor for advanced glycation end products (RAGE), i.e...
  39. A Role for Advanced Glycation End-Products in Diabetic Lung Injury
    Judson M Englert; Fiscal Year: 2010
    ..Recently our lab has implicated loss of the receptor for advanced glycation end-products (RAGE) as a key pathogenic step in the development of pulmonary fibrosis...
  40. Immunotherapy to prevent oral permalignant lesion recurrence and oral cancer.
    M Rita Young; Fiscal Year: 2013
    ..shared antigens are epidermal growth factor receptor (EGFR), the receptor for advanced glycation end products (RAGE) and the MUC1 mucin. The specific aims that will test our hypothesis are: 1...
  41. Metabolic Determinants of Cardiovascular Dysfunction in Obesity
    David W Stepp; Fiscal Year: 2013
    ..this association is strengthened by the increased expression of the Receptor for Advanced Glycation End-products (RAGE). Both deficits are corrected in obese PTP1B null mice with improved insulin resistance...
  42. Amyloid-B peptide on endothelial adhesion and its related cellular pathways
    James C M Lee; Fiscal Year: 2010
    ..from the signaling pathway involving the binding of A[unreadable] to receptor for advanced glycation end products (RAGE) to induce activations of NADPH oxidase and MAP kinases...
  43. Dana T Graves; Fiscal Year: 2016
    ..These include increased TNF-a, greater signaling of advanced glycation end products through RAGE and the impact of oral bacteria...
  44. Alzheimer's Disease Cooperative Study (ADCS)
    Paul S Aisen; Fiscal Year: 2012
    ..AD: (1) TTP488, a small novel molecule that binds to and inhibits the receptor for advanced glycation end products (RAGE) which blocks deposition of A?, (2) NAP, a novel eight amino acid peptide derived from the sequence of activity ..
  45. Sulfated Polysaccharide Derivatives for the Treatment of Rosacea
    NARAYANAM RAO; Fiscal Year: 2009
    ..alkylated polysaccharides potently inhibit of the interaction of the receptor for advanced glycation end-products (RAGE) with its many ligands, including carboxy-methyl lysine albumin (CML-BSA), S100 calgranulins, and high mobility box ..
  46. Frederick H Epstein; Fiscal Year: 2016
    ..mice), where we will test the hypothesis that advanced glycation end products (AGEs) and the receptor for AGE (RAGE) mediate hyperglycemic coronary microvascular dysfunction. To accomplish these goals we have three specific aims...
  47. Michal Toborek; Fiscal Year: 2015
    ..We identified that HIV-1-induced activity of the receptor for advanced glycation end products (RAGE) and alterations of ABC efflux transporters (namely, P-glycoprotein [Pgp] and breast cancer resistance protein [..
  48. RAGE-directed imaging in diabetes-induced accelerated atherosclerosis
    Lynne L Johnson; Fiscal Year: 2012
    ..approach to imaging accelerated atherosclerosis in diabetes by targeting Receptors Advanced Glycated Endproducts (RAGE)...
  49. Sulfated Polysaccharide Derivatives for Treatment of Macular Degeneration
    Jianxing Zhang; Fiscal Year: 2009
    ..HA derivatives also potently antagonize the interaction of the Receptor for Advanced Glycation End-products (RAGE) with its many ligands, including carboxy-methyl lysine albumin (CML-BSA), S100 calgranulins, and high mobility box ..
  50. The Role of RAGE in Asbestosis
    Tim Oury; Fiscal Year: 2007
    ..Notably, the receptor for advanced glycation end products (RAGE) when activated by its ligands induces chronic inflammation, enhances ROS production and leads to TGF-B synthesis...
  51. Estrogen and brain vascular inflammation in diabetics
    Dale Pelligrino; Fiscal Year: 2007
    ..levels of advanced glycation end-products (AGEs), while ERT promotes an increased expression of the AGE receptor, RAGE, on cerebrovascular endothelial cells...
  52. Effects of Diabetes Mellitus on the Development of Collateral Criculation
    Divya Gupta; Fiscal Year: 2009
    ..The purpose of this study is to compare collateral vessel development in animals based on their expression of RAGE in monocytes/macrophages, specifically...
  53. Induction of Inflammation by Mitochondrial Proteins
    Elliott Crouser; Fiscal Year: 2006
    ..turn, the release of pro-inflammatory cytokines from monocytes via receptors for advanced glycation end products (RAGE) and Toll-like receptors (TLR)...
  54. Novel Therapy for Diabetic Complications Using RAGE-Fc
    JAMES LARRICK; Fiscal Year: 2006
    ..Summary/Abstract: Recent investigations demonstrate the importance of receptor for advanced glycation end products (RAGE) mediated signal transduction in promoting pathogenic inflammation, renal failure and diabetic complications...
  55. ALZHEIMERS, GLYCATION, RECEPTORS AND OXIDANT STRESS
    Shi Du Yan; Fiscal Year: 1999
    ..products (AGEs); an heterogeneous group of structures which form cross links, interact with the Receptor for AGE (RAGE), and generate reactive oxygen intermediates (R01s)...
  56. Kevin J Tracey; Fiscal Year: 2014
    ..questions in this field, including: how do post-translational modifications alter HMGB1 interactions with TLR4 and RAGE, its two best understood and pre-eminent receptors? What is the effect of the HMGB1-TLR4 complex on activating ..
  57. Haichao Wang; Fiscal Year: 2016
    ..will test the hypothesis that SAA functions as a positive regulator of endotoxin-induced HMGB1 release through TLR4/RAGE receptors...
  58. Robert F Schwabe; Fiscal Year: 2016
    ..of HMGB1 to AH by measuring HMGB1 levels in AH patients, and determining the contribution of HMGB1 and its receptor RAGE in two acute-on-chronic models of AH in novel conditional HMGB1 knockout mice and RAGE-deficient mice, respectively ..
  59. Early Acute Lung Injury: Prospective Evaluation Prior to Respiratory Failure
    Joseph Levitt; Fiscal Year: 2013
    ..In SPECIFIC AIM 2, plasma levels of biomarkers (IL-8, sTNFr-1, vWF, ICAM-1, SP-D and RAGE) representing distinct pathways contributing to acute lung injury will be measured at time 0 and 24 hours after ..
  60. S100A8/A9 and carboxylated N-glycans in inflammation-mediated colon cancer
    GEETHA K SRIKRISHNA; Fiscal Year: 2010
    ..S100A8/A9 binds to a subpopulation of RAGE enriched for carboxylate glycans. They also bind to tumor cells and macrophages and activate NF-?B signaling...
  61. Domains of Inflammation and Risk of Dementia
    Annette L Fitzpatrick; Fiscal Year: 2013
    ..P (vascular inflammation), PAI-1 and adiponectin (metabolic function), receptor for advanced glycation endproduct - RAGE (oxidative stress) and endothelin-1 (endothelial function)...
  62. Inflammation and Oxidative Stress in Hyperglycemic Exacerbation of Infarct Size
    Irving L Kron; Fiscal Year: 2013
    ..acute hyperglycemia plays a central role in exacerbating MI size through their interaction with the AGE receptor (RAGE)...
  63. Novel Carboxylated Glycans in Cell Adhesion
    Hudson Freeze; Fiscal Year: 2006
    ..a secreted cytosolic molecule called amphoterin to the cell surface receptor for advanced glycation end products (RAGE). We found that this binding involves novel glycans that we discovered...
  64. The role of HMGB1-RAGE in hepatic fibrosis
    Zaki Megeed; Fiscal Year: 2006
    ..activates quiescent hepatic stellate cells (HSCs) by binding the receptor for advanced glycation end products (RAGE); and (2) RAGE ligation induces a RAGE positive-feedback loop that promotes fibrosis and inhibits apoptosis in ..
  65. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2009
    ..The multiligand Receptor for Advanced Glycation Endproducts (RAGE) is implicated in several extraskeletal degenerative disorders linked to low-grade tissue inflammation and aging, ..