Genomes and Genes
Gene Symbol: ADRB3
Description: adrenoceptor beta 3
Alias: BETA3AR, beta-3 adrenergic receptor, adrenergic, beta-3-, receptor, beta-3 adrenoceptor, beta-3 adrenoreceptor
Publications203 found, 100 shown here
- Possible association of beta2- and beta3-adrenergic receptor gene polymorphisms with susceptibility to breast cancerX E Huang
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
Breast Cancer Res 3:264-9. 2001The involvement of beta2-adrenergic receptor (ADRB2) and beta3-adrenergic receptor (ADRB3) in both adipocyte lipolysis and thermogenic activity suggests that polymorphisms in the encoding genes might be linked with interindividual ..
- Difficulty in losing weight by behavioral intervention for women with Trp64Arg polymorphism of the beta3-adrenergic receptor geneK Shiwaku
Department of Environmental Medicine, Shimane Medical, University, Izumo City, Shimane, Japan
Int J Obes Relat Metab Disord 27:1028-36. 2003..We investigated the response of body weight and metabolic factors to behavioral intervention in Japanese women with Trp64Arg mutation in the beta(3)AR gene...
- Single nucleotide polymorphism and lifestyle-related diseases in the Asia-Pacific region: comparative study in Okinawa, Palau and ThailandY Kagawa
High Technology Centre, Department of Medical Chemistry and Nutrition Clinic, Kagawa Nutrition University, Chiyoda Sakado, Saitama 350 0288, Japan
Asia Pac J Public Health 15:S10-4. 2003..For men, these associations were between beta3 adrenergic receptor (beta3AR) and diastolic blood pressure (DBP) (p<0.01), UCP3p and total cholesterol (p<0.01), UCP2 and age (p<0...
- Lifestyle modifies the relationship between body composition and adrenergic receptor genetic polymorphisms, ADRB2, ADRB3 and ADRA2B: a secondary analysis of a randomized controlled trial of physical activity among postmenopausal womenJennifer W Bea
Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
Behav Genet 40:649-59. 2010..Individuals with certain ADR genotypes may be more vulnerable to adverse changes in body composition with sedentary behavior, thus these candidate genes warrant further study...
- LEPR, ADBR3, IRS-1 and 5-HTT genes polymorphisms do not associate with obesityHatice Mergen
Department of Molecular Biology, Faculty of Science, Hacettepe University, Ankara, Turkey
Endocr J 54:89-94. 2007..Weak, though significant, association coefficients obtained with HTT and LEPR loci indicate that the genotype numbers at these loci may depend on BMI status to some extent...
- β1, β2, and β3 adrenoceptors and Na+/H+ exchanger regulatory factor 1 expression in human bronchi and their modifications in cystic fibrosisFlorian Bossard
INSERM, UMR 915, l institut du thorax, IRT UN, 8 quai Moncousu, Nantes, France
Am J Respir Cell Mol Biol 44:91-8. 2011..Furthermore, NHERF1 may be a new therapeutic target in patients with CF, to facilitate the trafficking of mutated CFTR to plasma membrane...
- Association between accumulation of visceral fat and the combination of β3 adrenergic receptor Trp64Arg, β2 adrenergic receptor Arg16Gly and uncoupling protein 1 -3826A>G polymorphisms detected by Smart Amplification Process 2Katsuhiko Tsunekawa
Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
Endocr J 58:1079-86. 2011..005). The present study demonstrated the interaction among β3AR Trp64Arg, β2AR Arg16Gly and UCP1 -3826A>G for the accumulation of visceral fat...
- Polymorphisms of interleukin-1 beta and beta 3-adrenergic receptor in Japanese patients with nonalcoholic steatohepatitisYasuko Nozaki
Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan
Alcohol Clin Exp Res 28:106S-110S. 2004..The aim of this study was to investigate the genetic predisposition on NASH pathogenesis in the Japanese population...
- Molecular characterization of the human beta 3-adrenergic receptorL J Emorine
CNRS, Universite Paris VII, France
Science 245:1118-21. 1989..In particular, novel beta-AR agonists having high thermogenic, antiobesity, and antidiabetic activities in animal models are among the most potent stimulators of the beta 3-AR...
- Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesityK Clement
Centre National de la Recherche Scientifique, Unité CNRS EP10, Institut Pasteur, Lille, France
N Engl J Med 333:352-4. 1995..The potential relevance of this receptor to obesity in humans led us to screen obese French patients for a recently identified mutation in the gene for the receptor...
- Tissue distribution of beta 3-adrenergic receptor mRNA in manS Krief
Centre National de la Recherche Scientifíque Unité Propre de Recherche 0415, Paris, France
J Clin Invest 91:344-9. 1993..beta 3-AR may thus be involved in the control of lipid metabolism, possibly from fat assimilation in the digestive tract, to triglyceride storage and mobilization in adipose tissues...
- Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gainT Fujisawa
Department of Geriatric Medicine, Osaka University Medical School, Japan
Diabetologia 39:349-52. 1996..These data suggest that the Trp64Arg mutation not only contributes to weight gain and age-at-onset of NIDDM but is also associated with susceptibility to NIDDM...
- Association of a genetic variation in the beta 3-adrenergic receptor gene with coronary heart disease among JapaneseK Higashi
First Department of Internal Medicine, National Defense Medical College, Saitama, Japan
Biochem Biophys Res Commun 232:728-30. 1997..This mutation was associated with coronary heart disease and obesity but was not with glucose and lipid metabolism disorders in Japanese nationals...
- Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptorJ Walston
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Clin Endocrinol Metab 85:4019-22. 2000....
- Beta 3-adrenergic receptor gene polymorphism and type 2 diabetes in a Caucasian populationA M Oeveren van-Dybicz
Department of Clinical Chemistry, Medisch Spectrum Twente, Enschede, The Netherlands
Diabetes Obes Metab 3:47-51. 2001..In this study we investigated the prevalence of the two beta 3-AR alleles in a Caucasian population and studied the association between the beta 3-AR genotype and metabolic disorders (obesity and type 2 diabetes)...
- The beta3-adrenergic receptor Trp64Arg mutation is not associated with coronary artery diseaseK Stangl
Medizinische Klinik und Poliklinik, Institut fur Klinische Pharmakologie, Deutsches Diabetes Forschungsinstitut an der Heinrich Heine, Universitat Dusseldorf, Germany
Metabolism 50:184-8. 2001....
- Relationship of the Trp64Arg polymorphism of the beta3-adrenoceptor gene to central adiposity and high blood pressure: interaction with age. Cross-sectional and longitudinal findings of the Olivetti Prospective Heart StudyP Strazzullo
Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Italy
J Hypertens 19:399-406. 2001....
- Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sampleT Oizumi
Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
Diabetes Care 24:1579-83. 2001..We examined the associations in a large population-based sample...
- Association of BMI with the beta3-adrenergic receptor gene polymorphism in Japanese: meta-analysisN Kurokawa
Department of Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan
Obes Res 9:741-5. 2001To assess the effect of the Trp64Arg polymorphism in the beta3-adrenergic receptor gene (ADRB3) on body mass index (BMI) in the Japanese population.
- Association of gene polymorphisms and bone density in Japanese girlsKiyoe Katsumata
Department of Pediatrics, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
J Bone Miner Metab 20:164-9. 2002..These results suggest that the Fok I polymorphism of the VDR gene and the Dra II polymorphism of the PTH gene are risk factors for low bone density in Japanese girls...
- Prediction of exercise-mediated changes in metabolic markers by gene polymorphismToshio Kahara
First Department of Internal Medicine, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8641, Japan
Diabetes Res Clin Pract 57:105-10. 2002..Polymorphisms of the beta3-adrenergic receptor (beta3AR) and uncoupling protein-1 (UCP-1) genes were analyzed with RFLP methods...
- Beta 3-adrenergic receptors regulate retinal endothelial cell migration and proliferationJena J Steinle
Department of Medical Physiology, College of Medicine, The Texas A and M University System Health Science Center, Temple, Texas 76504, USA
J Biol Chem 278:20681-6. 2003..These results support the hypothesis that beta3-adrenergic receptors play a role in proliferation and migration of cultured human retinal endothelial cells...
- Arg64 beta3-adrenoceptor variant and the components of energy expenditureJeremy Walston
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Obes Res 11:509-11. 2003..To determine Trp64Arg beta(3)-adrenoceptor genotype-specific differences in the components of energy expenditure...
- The Trp(64)Arg polymorphism of the beta(3)-adrenergic receptor gene is not associated with body weight or body mass index in Japanese: a longitudinal analysisYumi Matsushita
Graduate School, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
J Clin Endocrinol Metab 88:5914-20. 2003The beta(3)-adrenergic receptor (ADRB3) is expressed mainly in visceral adipose tissue and is thought to contribute to lipolysis and the delivery of free fatty acids to the portal vein...
- beta(3) Adrenergic receptor polymorphism and obesity-related phenotypes in hypertensive patientsKe Hao
Institute of Biomedicine, Anhui Medical University, Hefei, China
Obes Res 12:125-30. 2004..The beta(3) adrenergic receptor (ADRB3) is expressed in adipose tissue and plays a role in energy metabolism...
- Endothelial beta3-adrenoceptors mediate vasorelaxation of human coronary microarteries through nitric oxide and endothelium-dependent hyperpolarizationC Dessy
Unit of Pharmacology and Therapeutics, Saint Luc University Clinic and Université Catholique de Louvain, Brussels, Belgium
Circulation 110:948-54. 2004..beta3-Adrenoceptors were recently shown to vasodilate animal vessels and are expressed in human hearts...
- Effects of the Trp64Arg polymorphism in the beta3-adrenergic receptor gene on insulin sensitivity in small for gestational age neonatesXinli Wang
Department of Pediatrics, Third Hospital Peking University, Beijing 100083, People s Republic of China
J Clin Endocrinol Metab 89:4981-5. 2004..SGA is an important factor that predisposes to insulin resistance, and the Trp64Arg beta3-AR gene polymorphism may contribute to insulin resistance associated with reduced fetal growth...
- Interactive effects between polymorphisms in the beta-adrenergic receptors and longitudinal changes in obesityDarrell L Ellsworth
Cardiovascular Disease Research Program, Windber Research Institute, Windber, Pennsylvania, USA
Obes Res 13:519-26. 2005....
- Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE studyS G Terra
Department of Pharmacy Practice, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
Int J Obes (Lond) 29:746-54. 2005..the association between obesity and polymorphisms in genes of the beta(1)AR (ADRB1), beta(2)AR (ADRB2), beta(3)AR (ADRB3), Gs protein alpha (GNAS1), to which all three beta-receptors couple and the G protein beta3 subunit (GNB3), to ..
- Beta2- and beta3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 yearsKazuko Masuo
Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
Circulation 111:3429-34. 2005..Functional polymorphisms in the beta2- and beta3-adrenergic receptors have been reported to be associated with hypertension and obesity...
- Increased risk of obesity resulting from the interaction between high energy intake and the Trp64Arg polymorphism of the beta3-adrenergic receptor gene in healthy Japanese menKoichi Miyaki
Department of Preventive Medicine and Public Health, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
J Epidemiol 15:203-10. 2005..studies have investigated the interaction between the Trp64Arg polymorphism of the beta3-adrenergic receptor gene (ADRB3) and environmental factors...
- Meta-analysis of the association of the Trp64Arg polymorphism in the beta3 adrenergic receptor with insulin resistanceSiyan Zhan
Department of Community and Family Medicine, The Chinese University of Hong Kong, Hong Kong, China
Obes Res 13:1709-19. 2005..To clarify the possible association between the Trp64Arg polymorphism and insulin resistance (IR)...
- The ADRB3 Trp64Arg variant and obesity in African-American breast cancer casesR McKean-Cowdin
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
Int J Obes (Lond) 31:1110-8. 2007To determine if a missense change at codon 64 of ADRB3 (Trp64Arg), a candidate obesity gene, is associated with obesity and levels of subcutaneous or visceral fat in African-American breast cancer cases...
- beta2- and beta3-Adrenoceptor polymorphisms relate to subsequent weight gain and blood pressure elevation in obese normotensive individualsHideki Kawaguchi
Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
Hypertens Res 29:951-9. 2006..beta2- and beta3-adrenoceptor polymorphisms could predict the future BP elevation and further weight gain-induced BP elevation in originally obese subjects...
- T64A polymorphism in beta3-adrenergic receptor gene (ADRB3) and coronary heart disease: a case-cohort study and meta-analysisM H Zafarmand
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
J Intern Med 263:79-89. 2008A missense mutation of the human ADRB3 gene replacing tryptophan with arginine at codon 64 (Trp64Arg) has been related to obesity, insulin resistance, earlier onset of noninsulin-dependent diabetes mellitus and hypertension...
- No effect of the Trp64Arg variant of the beta3-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adultsShinichi Kuriyama
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8575, Japan
Metabolism 57:1570-5. 2008..47 (95% CI, -1.97 to 1.02). These results suggest that the presence of the Trp64Arg variant of the beta(3)-adrenergic receptor gene may not play a major role as a hindrance to weight reduction...
- An association between TRP64ARG polymorphism of the B3 adrenoreceptor gene and some metabolic disturbancesAibek E Mirrakhimov
National Centre of Cardiology and Internal medicine named by M Mirrakhimov, T Moldo 3, Bishkek, 720040, Kyrgyzstan
Cardiovasc Diabetol 10:89. 2011B3 adrenoreceptors (ADRB3) are abundant in adipose tissue and play the role in its metabolism and lipolysis...
- Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on long-term body weight change in Finnish type 2 diabetic and non-diabetic control subjectsK Sivenius
Department of Clinical Nutrition, University of Kuopio, Finland
Int J Obes Relat Metab Disord 24:514-9. 2000To investigate the independent and combined effects of the Trp64Arg polymorphism of the beta3-adrenergic receptor (beta3AR) gene and the (-3826) A-->G polymorphism of the uncoupling protein 1 (UCP1) gene on body weight change in type ..
- Studies of the synergistic effect of the Trp/Arg64 polymorphism of the beta3-adrenergic receptor gene and the -3826 A-->G variant of the uncoupling protein-1 gene on features of obesity and insulin resistance in a population-based sample of 379 young DS A Urhammer
Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark
J Clin Endocrinol Metab 85:3151-4. 2000....
- Gender specific associations of the Trp64Arg mutation in the beta3-adrenergic receptor gene with obesity-related phenotypes in a Mediterranean population: interaction with a common lipoprotein lipase gene variationD Corella
Department of Preventive Medicine and Public Health, Genetic and Molecular Epidemiology Unit, School of Medicine, University of Valencia, Valencia, Spain
J Intern Med 250:348-60. 2001To investigate the association between the Trp64Arg beta3-adrenergic receptor (ADRB3) mutation and obesity-related phenotypes in a Mediterranean Spanish population considering the effect of other genetic and environmental factors...
- Common variants in the lipoprotein lipase gene, but not those in the insulin receptor substrate-1, the beta3-adrenergic receptor, and the intestinal fatty acid binding protein-2 genes, influence the lipid phenotypic expression in familial combined hyperliFilomena Campagna
Dipartimento di Terapia Medica, Universita degli Studi di Roma La Sapienza, Rome, Italy
Metabolism 51:1298-305. 2002..Conversely, genetic variants in the IRS-1, FABP-2, and the beta3-AR gene appear not to have a major role as modifier genes in FCHL...
- Combined effects of genetic and environmental factors on insulin resistance associated with reduced fetal growthDelphine Jaquet
INSERM Unit 457, hôpital R Debré, 48 Boulevard Serurier, 75019 Paris, France
Diabetes 51:3473-8. 2002..We investigated whether polymorphisms in tumor necrosis factor (TNF)-alpha(G-308A), beta3 adrenoreceptor (ADRB3)(G+250C), and peroxisome proliferator-activated receptor (PPAR)-gamma2(Pro12Ala), key molecules of the adipose ..
- Molecular cloning of a human beta 3-adrenergic receptor cDNAJ M Lelias
Laboratoire de Biologie Moleculaire, Sanofi Elf Biorecherches, Labege, France
FEBS Lett 324:127-30. 1993..Interestingly, although a similar organization has been found in rodent genes, the rat beta 3-AR transcripts encode a receptor with an exon 2-derived C-terminus...
- Common variants in beta2- and beta3-adrenergic receptor genes and uncoupling protein 1 as predictors of the risk for type 2 diabetes and body weight changes. The Finnish Diabetes Prevention StudyT Salopuro
Clin Genet 66:365-7. 2004
- The Arg64 allele of the beta 3-adrenoceptor gene but not the -3826G allele of the uncoupling protein 1 gene is associated with increased leptin levels in the Spanish populationJoana Maria Ramis
Department de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Palma de Mollrca, Spain
Metabolism 53:1411-6. 2004..Furthermore, our results agree with the previously reported association between UCP1 -3826G allele and obesity and point to a gender-related effect...
- Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell linesE M Rohlfs
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 270:10723-32. 1995....
- Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) miceS Collins
Department of Medicine Gastroenterology, Duke University Medical Center, Durham, North Carolina 27710
Mol Endocrinol 8:518-27. 1994....
- The role of saturation of fat depots in the pathogenesis of insulin resistanceMathew A Cherian
Department of Medicine, University of North Dakota, School of Medicine and Health Sciences, 1919 Elm Street North, Fargo, ND 58102, USA
Med Hypotheses 66:763-8. 2006..resistance training-induced muscle hypertrophy, may also improve insulin resistance; (4) drugs, such as beta 3 adrenergic receptor agonists which promote lipolysis and have been suggested as possible agents in the treatment of obesity ..
- Atypical beta-adrenergic receptor in 3T3-F442A adipocytes. Pharmacological and molecular relationship with the human beta 3-adrenergic receptorB Feve
Unité 282 Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique, Hopital Henri Mondor, Creteil, France
J Biol Chem 266:20329-36. 1991..Although undetectable in preadipocytes, a major mRNA species of 2.3 kilobases (kb) and a minor one of 2.8 kb were observed in adipocytes by hybridization to a human beta 3-AR specific probe.(ABSTRACT TRUNCATED AT 400 WORDS)..
- Beta(3)-adrenoceptor agonist-induced increases in lipolysis, metabolic rate, facial flushing, and reflex tachycardia in anesthetized rhesus monkeysG J Hom
Merck Research Laboratories, Department of Animal Pharmacology, P O Box 2000, Rahway, NJ 07065, USA
J Pharmacol Exp Ther 297:299-307. 2001..These findings are consistent with a direct vasodilator effect of beta(3)-adrenergic receptor agonists...
- Diazoxide enhances basal metabolic rate and fat oxidation in obese Zucker ratsRamin Alemzadeh
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Metabolism 57:1597-607. 2008....
- Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cellsEnzo Nisoli
Center for Study and Research on Obesity, Department of Preclinical Sciences, LITA Vialba, L Sacco Hospital, University of Milan, Via G B Grassi 74, Italy
J Pathol 198:378-87. 2002..The study did not find any association between beta(3)-adrenoceptor gene polymorphism and noradrenergic signalling defects in MSL subjects with or without mitochondrial DNA mutations...
- Requirement of vimentin filament assembly for beta3-adrenergic receptor activation of ERK MAP kinase and lipolysisNaresh Kumar
Program in Endocrine Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 282:9244-50. 2007..The adipocyte beta3AR also activates extracellular signal-regulated kinases (ERK)-1 and -2 through direct recruitment and activation of ..
- Role of beta1-adrenoceptor in increased lipolysis in cancer cachexiaDong xing Cao
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
Cancer Sci 101:1639-45. 2010..Gene expressions of beta1-adrenoceptor (ADRB1), beta2-adrenoceptor (ADRB2), beta3-adrenoceptor (ADRB3), alpha2C-adrenoceptor (ADRA2C), natriuretic peptide receptor A (NPRA), insulin receptor (INSR), and HSL were ..
- Transcriptional modulation by n-butyric acid of beta 1-, beta 2-, and beta 3-adrenergic receptor balance in 3T3-F442A adipocytesS Krief
Centre National de la Recherche Scientifíque Unité Propre de Recherche 0415, Paris, France
J Biol Chem 269:6664-70. 1994..The differential regulation of the three beta-ARs by n-butyric acid, a dietary factor produced from colonic fermentation, may have significant nutritional and energetic consequences...
- Molecular cloning and pharmacological characterization of the bovine beta 3-adrenergic receptorF Pietri-Rouxel
Institut Cochin de Genetique Moleculaire, Centre Nationale de la Recherche Scientifique, UPR, Paris, France
Eur J Biochem 230:350-8. 1995....
- Expression of the human beta(3)-adrenergic receptor gene in SK-N-MC cells is under the control of a distal enhancerV S Susulic
Metabolic Diseases Department, Wyeth Ayerst Laboratories, Inc, CN 8000, Princeton, New Jersey 08543, USA
Endocrinology 142:1935-49. 2001..These data also suggest that brown adipose tissue-specific transcription factor(s) may be involved in the tissue-specific expression of the beta(3)-adrenergic receptor gene...
- Effects of beta3-adrenergic receptor activation on rat urinary bladder hyperactivity induced by ovariectomyF Aura Kullmann
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, E1340 Biomedical Science Tower, Pittsburgh, PA 15261, USA
J Pharmacol Exp Ther 330:704-17. 2009..This suggests that beta(3)AR agonists should prove effective for the treatment of overactive bladder symptoms in the postmenopausal population...
- Beta 3-adrenergic receptor-mediated lipolysis and oxygen consumption in brown adipocytes from cynomolgus monkeysD S Meyers
Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000, USA
J Clin Endocrinol Metab 82:395-401. 1997..These results demonstrate that all three beta-adrenergic receptor subtypes are coupled to lipolysis and oxygen consumption in brown adipocytes from cynomolgus monkeys...
- Beta3-adrenergic regulation of leptin, food intake, and adiposity is impaired with ageM V Kumar
Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville 32610, USA
Pflugers Arch 438:681-8. 1999..Beta3-adrenergic agonists are anti-obesity agents in rodents, and activation of beta3-adrenergic receptors (beta3AR) mediates an acute decrease in food consumption, increased thermogenesis in brown adipose tissue (BAT), increased ..
- No association between body mass index and beta(3)-adrenergic receptor variant (W64R) in children with premature pubarche and adolescent girls with hyperandrogenismS F Witchel
Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Fertil Steril 73:509-15. 2000To determine if the Trp(64)Arg (W64R) variant of the beta(3)-adrenergic receptor (ADRB3) could be used as a genetic marker to define risk for polycystic ovary syndrom (PCOS) and/or obesity in children and adolescents.
- Effect of the beta(3)-adrenergic agonist Cl316,243 on functional differentiation of white and brown adipocytes in primary cell cultureS Klaus
The German Institute of Human Nutrition DIfE, Bergholz Rehbrücke, Germany
Biochim Biophys Acta 1539:85-92. 2001....
- Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese menThomas M Larsen
Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Copenhagen, Denmark
Am J Clin Nutr 76:780-8. 2002..Stimulation of energy expenditure (EE) with selective thermogenic beta-adrenergic agonists may be a promising approach for treating obesity...
- Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomographyMasami Nemoto
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
Cardiovasc Diabetol 6:23. 2007..This study evaluated the effect of genetic polymorphism of enzymes producing or responsible for reducing ROS on coronary artery calcification in type 2 diabetes (T2D)...
- Acupuncture and exercise restore adipose tissue expression of sympathetic markers and improve ovarian morphology in rats with dihydrotestosterone-induced PCOSLouise Mannerås
Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
Am J Physiol Regul Integr Comp Physiol 296:R1124-31. 2009..In mesenteric adipose tissue, expression of beta(3)-adrenergic receptor (ADRB3), nerve growth factor (NGF), and neuropeptide Y (NPY) mRNA was higher in untreated PCOS rats than in controls...
- Preadipocyte transplantation: an in vivo study of direct leptin signaling on adipocyte morphogenesis and cell sizeKaiying Guo
Division of Molecular Genetics, Columbia University, New York, NY 10032, USA
Am J Physiol Regul Integr Comp Physiol 296:R1339-47. 2009....
- (123)I- or (125)I-metaiodobenzylguanidine visualization of brown adipose tissueChio Okuyama
Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
J Nucl Med 43:1234-40. 2002..The true nature of such accumulations is unknown, and we hypothesized that they represent interscapular brown adipose tissue (IBAT) visualized by scintigraphy...
- Characteristics of lipolysis in white adipose tissues of SHR/NDmc-cp rats, a model of metabolic syndromeNaoki Harikai
School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo 663 8179, Japan
Metabolism 56:847-55. 2007....
- Excess weight gain during the early postnatal period is associated with permanent reprogramming of brown adipose tissue adaptive thermogenesisXiao Qiu Xiao
Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
Endocrinology 148:4150-9. 2007..Overall, these observations provide the first evidence that postnatal excess weight gain results in abnormalities in BAT thermogenesis and sympathetic outflow, which likely increases susceptibility to obesity in adulthood...
- Impact of nandrolone decanoate on gene expression in endocrine systems related to the adverse effects of anabolic androgenic steroidsJohan Alsiö
Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Uppsala, Sweden
Basic Clin Pharmacol Toxicol 105:307-14. 2009..The results provide evidence for wide ranging effects of AAS on the hypothalamic-pituitary-adrenal axis, adipose tissue and substrates of the renal control of blood pressure...
- Insulin resistance and type 2 diabetes mellitus: its relationship with the beta 3-adrenergic receptorE Garcia-Rubi
Endocrinology, Diabetes, and Metabolism Unit, University of Vermont College of Medicine, Burlington 05405 0068, USA
Arch Med Res 30:459-64. 1999..Association with obesity or diabetes in humans is still controversial. This difference between animal and human models may be explained by the different quantity and distribution of metabolically active brown adipose tissue in the two...
- Modulation of porcine adipocyte beta-adrenergic receptors by hormones and butyrateS T Ding
USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030 2600, USA
J Anim Sci 78:927-33. 2000..For example, glucocorticoids decrease the beta1AR and the beta3AR but increase the beta2AR. Insulin decreases the beta3AR...
- The human beta 3-adrenergic receptor is resistant to short term agonist-promoted desensitizationF Nantel
Departement de Biochimie, Universite de Montreal, Quebec, Canada
Mol Pharmacol 43:548-55. 1993....
- TRP64ARG beta 3-adrenergic receptor and obesity in Mexican AmericansK Silver
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Hum Genet 101:306-11. 1997..Since its effects are modest, study design (e.g., subject selection, genetic background, and statistical analyses) may influence which traits are associated with this variant and whether or not the effect is detectable in heterozygotes...
- Differential regulation of mouse uncoupling proteins among brown adipose tissue, white adipose tissue, and skeletal muscle in chronic beta 3 adrenergic receptor agonist treatmentH Yoshitomi
Tsukuba Research Laboratories, Eisai Co, Ltd, Ibaraki, Japan
Biochem Biophys Res Commun 253:85-91. 1998..between the UCPs expressions and insulin sensitivity improvement, we treated KK-Ay mice with beta 3 adrenergic receptor agonist for 21 days and examined the changes of the UCPs mRNA expressions in various tissues...
- Molecular scanning of the beta-3-adrenergic receptor gene in Pima Indians and CaucasiansK Silver
Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21201, USA
Diabetes Metab Res Rev 15:175-80. 1999The beta-3-adrenergic receptor (beta3AR) stimulates lipolysis and thermogenesis in adipocytes...
- Acute effect of L-796568, a novel beta 3-adrenergic receptor agonist, on energy expenditure in obese menMarleen A van Baak
Nutrition and Toxicology Research Institute NUTRIM, Department of Human Biology, Maastricht University, The Netherlands
Clin Pharmacol Ther 71:272-9. 2002....
- Beta 3-adrenergic receptors mediate choroidal endothelial cell invasion, proliferation, and cell elongationJena J Steinle
Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, IL 62901, USA
Exp Eye Res 80:83-91. 2005..In conclusion, beta(3)-adrenergic receptors may play a role in choroidal endothelial cell invasion and elongation, while playing a more limited function in regulation of cell proliferation...
- Substituted 1,2,3,4-tetrahydroquinolin-6-yloxypropanes as beta3-adrenergic receptor agonists: design, synthesis, biological evaluation and pharmacophore modelingNeeraj Shakya
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India
Bioorg Med Chem 17:830-47. 2009..A putative pharmacophore model has been modeled considering the above four active molecules which distinguishes well between the active and inactive molecules...
- Long-term agonist exposure induces upregulation of beta 3-adrenergic receptor expression via multiple cAMP response elementsR F Thomas
Department of Medicine Pulmonary, Duke University Medical Center, Durham, NC 27710
Proc Natl Acad Sci U S A 89:4490-4. 1992..Thus, the beta 3AR undergoes a paradoxical increase in receptor expression during chronic agonist exposure...
- Molecular scanning of beta-3-adrenergic receptor gene in total congenital lipoatrophic diabetes mellitusK Silver
Johns Hopkins University School of Medicine, Division of Endocrinology and Metabolism, Baltimore, Maryland 21287, USA
J Clin Endocrinol Metab 82:3395-8. 1997..In conclusion, mutations in the beta 3AR gene do not appear to be involved in the development of congenital total lipoatrophy...
- Role of the beta(3)-adrenergic receptor and/or a putative beta(4)-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated receptor-gamma coactivator-1O Boss
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
Biochem Biophys Res Commun 261:870-6. 1999..This effect is probably indirect, as muscle does not seem to express beta(3)-AR. In addition, our data suggest that BRL 37344 and CGP 12177 act, in part, through an as yet unidentified receptor, possibly a beta(4)-AR...
- Biochemical activities of trimetoquinol analogs at human beta(1)- and beta(3)-adrenergic receptorsA A Konkar
Division of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA
Pharmacology 62:45-55. 2001....
- The pharmacokinetics of a thiazole benzenesulfonamide beta 3-adrenergic receptor agonist and its analogs in rats, dogs, and monkeys: improving oral bioavailabilityRalph A Stearns
Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey 07065, USA
Drug Metab Dispos 30:771-7. 2002....
- Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditureJun Nakae
Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
Diabetes 57:563-76. 2008..Forkhead box-containing protein O subfamily (FoxO) 1 mediates insulin action at the transcriptional level. However, physiological roles of FoxO1 in adipose tissue remain unclear...
- The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from beta3-adrenoceptor agonistsJonathan R S Arch
Clore Laboratory, University of Buckingham, Buckingham, MK18 1EG, UK
Naunyn Schmiedebergs Arch Pharmacol 378:225-40. 2008Although beta3-adrenoceptor (beta3AR) agonists have not become drugs for the treatment of obesity or diabetes, they offer perspectives on obesity drug discovery, the physiology of energy expenditure and receptor pharmacology...
- Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5Kouji Hattori
Chemistry Research Laboratories, Astellas Pharma Inc, 21, Miyukigaoka, Tsukuba shi, Ibaraki 305 8585, Japan
J Med Chem 52:3063-72. 2009..In general, increased lipophilicity led to decreased potency for the bladder relaxation compared with cAMP accumulation in CHO cell lines, indicating that lipophilicity is crucial for OAB drug candidates to improve beta(3) activity...
- Potent and selective human beta(3)-adrenergic receptor antagonistsM R Candelore
Department of Molecular Pharmacology Immunology and Rheumatology, Merck and Co, Rahway, New Jersey, USA
J Pharmacol Exp Ther 290:649-55. 1999..In addition, we describe specific 3'-phenoxy substitutions that transform these compounds from potent agonists into selective antagonists...
- Differentiation-dependent inhibition of proteolysis by norepinephrine in brown adipocytesM Desautels
Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E5
Am J Physiol 277:E215-22. 1999..Thus inhibition of proteolysis by NE and insulin in mature brown adipocytes is likely an important process contributing to brown fat growth and atrophy under many physiological or pathological conditions...
- The full expression of fasting-induced torpor requires beta 3-adrenergic receptor signalingSteven J Swoap
Department of Biology, Williams College, Williamstown, Massachusetts 01267, USA
J Neurosci 26:241-5. 2006..These results define a critical role of peripheral SNS activity at beta3-AR-containing tissues in the torpor adaptation to limited energy availability and cool ambient temperature...
- Ethanolic extracts of Brassica campestris spp. rapa roots prevent high-fat diet-induced obesity via beta(3)-adrenergic regulation of white adipocyte lipolytic activitySojin An
National Research Laboratory of Lipid Metabolism and Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea
J Med Food 13:406-14. 2010..These results suggest that EBR may have potential as a safe and effective anti-obesity agent via the inhibition of adipocyte lipid accumulation and the stimulation of beta(3)-AR-dependent lipolysis...
- Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor functionJ Hoffstedt
Department of Medicine, Huddinge University Hospital, Karolinska Institute, Sweden
Diabetes 48:203-5. 1999
- Genetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzleV S Basile
Centre for Addiction and Mental Health, Clarke Division, University of Toronto, Ontario, Canada
J Clin Psychiatry 62:45-66. 2001..genes (H1R/H2R); the cytochrome P450 1A2 gene (CYPIA2); the beta3 and alpha,alpha-adrenergic receptor genes (ADRB3/ADRAIA); and tumor necrosis factor alpha (TNF-alpha)...
- Effect of Trp64Arg mutation of the beta3-adrenergic receptor gene and C161T substitution of the peroxisome proliferator activated receptor gamma gene on obesity in Japanese childrenRina Arashiro
Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0125 Japan
Pediatr Int 45:135-41. 2003..For this reason, we studied the effects of Trp64Arg mutation of the beta3-AR gene and C161T substitution of the PPARgamma gene on obesity in Japanese children...
- Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndromeChisato Murata
Department of Community Health, Tokai University School of Medicine, Kanagawa, Japan
Metabolism 52:1096-101. 2003..In conclusion, evaluating the genotype of ALDH2 and beta3-AR may assist in predicting and preventing the development of fatty liver which may be related to multiple risk factor syndrome...
- Potent and selective, sulfamide-based human beta 3-adrenergic receptor agonistsRobert L Dow
Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, CT 06340, USA
Bioorg Med Chem Lett 14:3235-40. 2004..This modification allows for a significant reduction in molecular weight, while maintaining single-digit nanomolar potencies at the beta(3)-AR and high selectivities versus the beta(2)- or beta(3)-AR...
- Ethnic differences of coronary artery disease-associated SNPs in two Israeli healthy populations using MALDI-TOF mass spectrometryKenji Nakai
Department of Laboratory Medicine, Iwate Medical University, Morioka 020 8505, Japan
Life Sci 75:1003-10. 2004..in allelic frequency were observed in the 1166A>C of the AGTR1 gene, R158C of the Apo E gene, W64R of the ADRB3 gene, S101S of the TIMP 2 gene, and A222V of the MTHFR gene with respect to allele frequency...
- Lack of relationship between beta3-adrenergic receptor gene polymorphism and gestational diabetes mellitus in a Taiwanese populationPo Jung Tsai
Department of Food Science, Yuanpei University of Science and Technology, Hsin Chu, Taipei, Taiwan
Metabolism 53:1136-9. 2004The Trp64Arg polymorphism of beta(3)-adrenergic receptor (ADRB3) has been reported to be associated with insulin resistance and gestational diabetes mellitus (GDM)...
- Haplotype structure of the beta adrenergic receptor genes in US Caucasians and African AmericansInna Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Eur J Hum Genet 13:341-51. 2005..Previously, three beta-AR genes (ADRB1, ADRB2 and ADRB3) were resequenced, identifying polymorphisms that were used in genetic association studies of cardiovascular and ..
- [Relationship between of carotid ultrasonography in Japanese hypertensive subjects for intima-media thickness and plaque, and candidate gene polymorphism--possibility of early detection of arteriosclerotic disease]Shigeru Terajima
Department of Neurophysiology, Graduate School of Environmental Health Sciences, Azabu University, Sagamihara 229 8501
Rinsho Byori 53:290-6. 2005....
- The Trp64Arg beta3-adrenergic receptor amino-acid variant is not associated with overweight and type 2 diabetes mellitus in Polish populationJ Kasznicki
Department of Clinical Pharmacology, Medical University of Lodz, Lodz, Poland
Exp Clin Endocrinol Diabetes 113:593-7. 2005..13 %, OR 0.97, CI 0.54 - 1.76). The obtained results suggest no association between Trp64Arg polymorphism of the beta3-AR gene and the incidence of overweight and type 2 diabetes mellitus in Polish population...
- MICHAEL L CAMILLERI; Fiscal Year: 2014..fasting and postprandial accommodation volume in overweight and obese adults with allelic variants at the FTO, ADRB3, uncoupling protein-2, ADR2A, GNB3 loci to adults with common alleles...
- Paul S Frenette; Fiscal Year: 2016..the administration of the HSC mobilizer granulocyte colony- stimulating factor (G-CSF) or b3 adrenergic receptor (Adrb3) activation...
- Beta-adrenoceptor genetic polymorphisms and obesityJulie Johnson; Fiscal Year: 2002..we will be studying the association between obesity and genes of the beta1AR (ADRB1), the beta2AR (ADRB2), the beta3AR (ADRB3), the Gs protein alpha subunit (GNAS1) (all three betaARs couple with Gs) and the G protein beta3 subunit (..
- Transcription & Function of Adipocyte Beta3AR in ObesitySheila Collins; Fiscal Year: 2006The beta3-adrenergic receptor (beta3AR) is a G protein- coupled receptor (GPCR) expressed predominantly in adipose tissue, where it mediates the effects of noradrenaline-stimulated lipolysis in white adipose tissue (WAT) and ..
- BETA 3-ADRENOCEPTORS AND MAP KINASE IN ADIPOCYTESSheila Collins; Fiscal Year: 2003The beta3-adrenergic receptor (beta3AR) is a G protein-coupled receptor (GPCR) expressed predominantly in adipose tissue, where it mediates the effects of noradrenaline-stimulated lipolysis in white adipose tissue (WAT) and thermogenesis ..
- Mechanisms of Energy Balance in the AdipocyteRichard Bradley; Fiscal Year: 2005..abstract_text> ..
- ENERGY EXPENDITURE IN POSTOBESE WOMENEric Poehlman; Fiscal Year: 1999..in women is unknown A novel mutation (codon 64 TGG(TrP)->CGG(Arg); W64R) in the beta3- adrenergic receptor (beta3AR) gene was recently detected in a number of ethnic populations...
- GENETIC INTERACTIONS AND INSULIN SECRETIONKristi Silver; Fiscal Year: 2003..Asp76Asn, Beta 2/NeuroD Ala45Thr, insulin receptor substrate-2 (IRS-2) Gly1057Asp, and beta-3adrenergic receptor (beta3AR) Trp64Arg]...
- FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDYMaria Martinez; Fiscal Year: 2003..that influence obesity and insulin (androgen receptor gene (AR), vitamin D receptor gene(VDR), insulin receptor (ADRB3)) will be examined both independently and in conjunction with metabolic factors to determine differences in ..
- FOUR-CORNERS BREAST CANCER STUDYTim Byers; Fiscal Year: 2003..that influence obesity and insulin (androgen receptor gene (AR), vitamin D receptor gene(VDR), insulin receptor (ADRB3)) will be examined both independently and in conjunction with metabolic factors to determine differences in ..
- FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDYMARTHA OR MARTY SLATTERY; Fiscal Year: 2003..that influence obesity and insulin (androgen receptor gene (AR), vitamin D receptor gene(VDR), insulin receptor (ADRB3)) will be examined both independently and in conjunction with metabolic factors to determine differences in ..
- THE 4 CORNERS BREAST AND ENDOMETRIAL CANCER STUDYKathy Baumgartner; Fiscal Year: 2003
- BETA 1 AND BETA 3 ADRENORECEPTORSJAMES GRANNEMAN; Fiscal Year: 2001..Aim 2. To further characterize the differential signaling properties of beta1- beta3-AR and to examine the cellular and molecular basis. Specific Aim 3. To examine the molecular pharmacology of beta3-AR-selective agonists. ..
- TRH in mediating the bradycardia of caloric restrictionSteven Swoap; Fiscal Year: 2005..Resting and intrinsic HRs will be measured before and during a caloric restriction period. ..
- Analysis of Therapeutic Adipose Tissue RemodelingJAMES GRANNEMAN; Fiscal Year: 2004..2) To examine adipose tissue cellular dynamics during therapeutic remodeling induced by agonist activation of beta3-adrenergic receptors and PPAR-gamma. ..
- PHARMACOGENETICS OF ASTHMA MONOTHERAPYJohn Lima; Fiscal Year: 2005..The results of this pharmacogenetic study may facilitate the optimal selection of monotherapy in asthma. ..
- IMAGING BETA CELL FUNCTION WITH BIOSENSORSLouis Philipson; Fiscal Year: 2007..The studies will provide new understanding of islet cell biology that will benefit clinical strategies to preserve and maintain functional 13-cell mass. ..
- Development of a Mouse Model for FrailtyJeremy Walston; Fiscal Year: 2008..We expect to find that the frail mouse has higher levels of inflammatory markers, muscle weakness, and altered gene expression as it gets older, similar to what is found in frail, older humans. [unreadable] [unreadable] [unreadable]..
- Type 2 Diabetes Gene Discovery Linked to 3p in HispanicsDonna Lehman; Fiscal Year: 2009..In addition, the utilization of a novel statistical functional genomic analysis (BQTN) in the 3rd specific aim of this proposal should enhance the final stage of identifying the specific variants involved. ..
- NIDDM SUSCEPTIBILITY GENES IN MEXICAN AMERICANSDonna M Lehman; Fiscal Year: 2010..5 LOD support interval. Furthermore, the utilization of a novel statistical functional genomic analysis (Bayesian quantitative trait nucleotide analysis) should enhance the final stage of identifying the specific variants involved. ..
- Genetic studies on models of nuclear cataractsD Sidjanin; Fiscal Year: 2009..Specific Aim (4): Once genes and mutations responsible for the Coc and Lop4 phenotypes are identified, the focus will be on characterizing the process of cataract development at the molecular level. ..
- LEUKOTRIENE POLYMORPHISMS & MONTELUKAST RESPONSEJohn Lima; Fiscal Year: 2003..This information may lead to individualization of asthma medications based on the genetic make-up of the patient. ..
- Regulation of Angiogenesis via EphB4 SignalingJENA STEINLE; Fiscal Year: 2002..These results from both mesenteric and retinal endothelial cells will greatly increase our understanding of Eph B4 receptor regulation of the various stages of angiogenesis. ..
- NFkb Related Genetic Influences on Inflammation and Poor Health in Older AdultsJeremy Walston; Fiscal Year: 2009..Clinically meaningful genotypes will highlight potential biologic pathways for interventions into a range of poor health outcomes in older adults. ..