ADRB2

Summary

Gene Symbol: ADRB2
Description: adrenoceptor beta 2
Alias: ADRB2R, ADRBR, B2AR, BAR, BETA2AR, beta-2 adrenergic receptor, adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, beta-2 adrenoceptor, beta-2 adrenoreceptor, catecholamine receptor
Species: human

Top Publications

  1. ncbi GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function
    Daniel M Rosenbaum
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 318:1266-73. 2007
  2. ncbi Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review
    Ammarin Thakkinstian
    Clinical Epidemiology Unit, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Am J Epidemiol 162:201-11. 2005
  3. pmc Activation mechanism of the β2-adrenergic receptor
    Ron O Dror
    DE Shaw Research, New York, NY 10036, USA
    Proc Natl Acad Sci U S A 108:18684-9. 2011
  4. ncbi Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties
    S A Green
    Department of Medicine Pulmonary, University of Cincinnati Medical Center, Ohio 45267 0564
    Biochemistry 33:9414-9. 1994
  5. ncbi A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated so
    Arne Heydorn
    Laboratory for Molecular Pharmacology, Department of Pharmacology, Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    J Biol Chem 279:54291-303. 2004
  6. pmc The arrestin domain-containing 3 protein regulates body mass and energy expenditure
    Parth Patwari
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 14:671-83. 2011
  7. ncbi Association of β(2)-adrenergic receptor polymorphisms with asthma in a North Indian population
    Niti Birbian
    Department of Biotechnology, Panjab University, Chandigarh, India
    Lung 190:497-504. 2012
  8. ncbi beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95
    J Xu
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:41310-7. 2001
  9. ncbi Distribution in allele frequencies of predisposition-to-atopy genotypes in Chinese children
    T F Leung
    Department of Paediatrics, Chinese University of Hong Kong, Hong Kong, China
    Pediatr Pulmonol 34:419-24. 2002
  10. ncbi Association between beta2-adrenoceptor polymorphisms and asthma diagnosis among Mexican adults
    Alfredo A Santillan
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autónoma de Nuevo León UANL, Monterrey, Mexico
    J Allergy Clin Immunol 112:1095-100. 2003

Research Grants

  1. PSYCHONEUROIMMUNOLOGY--MODULATION OF T CELL FUNCTION
    THOMAS ROSZMAN; Fiscal Year: 1999
  2. IL-1 AND B-ADRENERGIC SYSTEM OF HUMAN AIRWAY EPITHELIUM
    Steven Kelsen; Fiscal Year: 1999
  3. PSYCHONEUROIMMUNOLOGY: MODULATION OF T-CELL FUNCTION
    THOMAS ROSZMAN; Fiscal Year: 1993
  4. Howard A Rockman; Fiscal Year: 2016
  5. Beta2-Adrenergic Receptor Gene Variation and Cardiovascular Control in Humans
    John H Eisenach; Fiscal Year: 2012
  6. Rong Z Gan; Fiscal Year: 2015
  7. SCOTT MCNABB LOUGHHEAD; Fiscal Year: 2014
  8. An Accurate Mass TOF Mass Spectrometer - HPLC System for Marine Organic Chemistry
    William Fenical; Fiscal Year: 2012
  9. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
  10. Impact of 100% Smoke-Free Laws on the Health of Children and Infants
    Dhaval M Dave; Fiscal Year: 2013

Detail Information

Publications400 found, 100 shown here

  1. ncbi GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function
    Daniel M Rosenbaum
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 318:1266-73. 2007
    The beta2-adrenergic receptor (beta2AR) is a well-studied prototype for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) that respond to diffusible hormones and neurotransmitters...
  2. ncbi Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review
    Ammarin Thakkinstian
    Clinical Epidemiology Unit, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Am J Epidemiol 162:201-11. 2005
    ..001). Haplotype analysis suggests that there may be an interaction between the two sites, with a lower risk of asthma associated with the Glu27 allele (compared with Gln27), and that this risk is modified by the allele at position 16...
  3. pmc Activation mechanism of the β2-adrenergic receptor
    Ron O Dror
    DE Shaw Research, New York, NY 10036, USA
    Proc Natl Acad Sci U S A 108:18684-9. 2011
    ..By capturing this fundamental signaling process in atomic detail, our results may provide a foundation for the design of drugs that control receptor signaling more precisely by stabilizing specific receptor conformations...
  4. ncbi Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties
    S A Green
    Department of Medicine Pulmonary, University of Cincinnati Medical Center, Ohio 45267 0564
    Biochemistry 33:9414-9. 1994
    ..abstract truncated at 250 words)..
  5. ncbi A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated so
    Arne Heydorn
    Laboratory for Molecular Pharmacology, Department of Pharmacology, Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    J Biol Chem 279:54291-303. 2004
    ..It is concluded that the tail library provides useful information on the general importance of certain adaptor proteins, for example, in this case, ruling out EBP50 as being a broad spectrum-recycling adaptor...
  6. pmc The arrestin domain-containing 3 protein regulates body mass and energy expenditure
    Parth Patwari
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 14:671-83. 2011
    ..These results demonstrate that ARRDC3 is a gender-sensitive regulator of obesity and energy expenditure and reveal a surprising diversity for arrestin family protein functions...
  7. ncbi Association of β(2)-adrenergic receptor polymorphisms with asthma in a North Indian population
    Niti Birbian
    Department of Biotechnology, Panjab University, Chandigarh, India
    Lung 190:497-504. 2012
    ..The present study aimed at evaluating the role of β(2)AR-16 and β(2)AR-27 gene polymorphisms in asthma...
  8. ncbi beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95
    J Xu
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:41310-7. 2001
    ....
  9. ncbi Distribution in allele frequencies of predisposition-to-atopy genotypes in Chinese children
    T F Leung
    Department of Paediatrics, Chinese University of Hong Kong, Hong Kong, China
    Pediatr Pulmonol 34:419-24. 2002
    ..Additional studies involving larger samples are required to investigate the association between asthma or atopy and the genotypes studied to date in Chinese children...
  10. ncbi Association between beta2-adrenoceptor polymorphisms and asthma diagnosis among Mexican adults
    Alfredo A Santillan
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autónoma de Nuevo León UANL, Monterrey, Mexico
    J Allergy Clin Immunol 112:1095-100. 2003
    ..The nature of the relation in a more homogeneous population is uncertain...
  11. ncbi beta2-Adrenergic receptor polymorphisms and asthma in the North Indian population
    Pallav Bhatnagar
    GenoMed Lab, Gene Quest Laboratory, Nicholas Piramal India Ltd at the Institute of Genomics and Integrative Biology, CSIR, Delhi 110007, India
    Pharmacogenomics 6:713-9. 2005
    The beta(2)-adrenergic receptor (ADRB2) polymorphisms are known to be functionally relevant and disease modifying in subjects with asthma. However, the association of these polymorphisms with asthma remains to be established...
  12. ncbi A novel sorting sequence in the beta2-adrenergic receptor switches recycling from default to the Hrs-dependent mechanism
    Aylin C Hanyaloglu
    Department of Psychiatry, University of California, San Francisco, California 94158, USA
    J Biol Chem 282:3095-104. 2007
    ....
  13. doi An association study of 13 SNPs from seven candidate genes with pediatric asthma and a preliminary study for genetic testing by multiple variants in Taiwanese population
    Jiu Yao Wang
    Department of Pediatrics and Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Clin Immunol 29:205-9. 2009
    ..Because of the heterogeneity of the disease and the genetic and cultural differences among different populations, a proper association study and genetic testing for asthma and susceptibility genes is difficult to perform...
  14. doi β(2) -adrenoreceptor polymorphisms in asthmatic and non-asthmatic schoolchildren from Colombia and their relationship to treatment response
    Carlos Isaza
    Facultad de Ciencias de la Salud, Universidad Tecnologica de Pereira, Pereira, Colombia
    Pediatr Pulmonol 47:848-55. 2012
    ..was to establish the relationship between the Gln27Glu and Arg16Gly alleles of the β(2) -adrenergic receptor (ADRB2) gene with respect to the susceptibility to and severity of asthma, as well as the response to treatment in ..
  15. ncbi Common variants in the beta2-(Gln27Glu) and beta3-(Trp64Arg)--adrenoceptor genes are associated with elevated serum NEFA concentrations and type II diabetes
    M Carlsson
    Department of Endocrinology Malmö University Hospital, Sweden
    Diabetologia 44:629-36. 2001
    ..To address this question we studied whether common variants in two genes encoding for key regulators of lipolysis, the beta2- and beta3- adrenoceptors (B2AR and B3AR) are associated with NEFA concentrations and Type II diabetes.
  16. doi Polymorphisms at the beta2-adrenergic receptor gene influence Alzheimer's disease susceptibility
    Jin Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, Affiliated Hospital of Qingdao University Medical College, Shandong Province, PR China
    Brain Res 1210:216-22. 2008
    ..004). Our results suggest that variations in the beta2-AR gene play an important role in the pathogenesis of sporadic LOAD, and interact with the epsilon4 allele to markedly increase the LOAD risk...
  17. doi Genotypes and haplotypes of beta2-adrenergic receptor and parameters of the metabolic syndrome in Korean adolescents
    Hye Soon Park
    Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138 736, Korea
    Metabolism 57:1064-70. 2008
    ..the association between single nucleotide polymorphisms (SNPs) and haplotype of the beta(2)-adrenergic receptor (ADRB2) gene and parameters of the metabolic syndrome in Korean adolescents...
  18. pmc Ligand-specific interactions modulate kinetic, energetic, and mechanical properties of the human β2 adrenergic receptor
    Michael Zocher
    Department of Biosystems Science and Engineering, ETH Zurich, Mattenstr 26, 4058 Basel, Switzerland
    Structure 20:1391-402. 2012
    ..These interactions were specific to the efficacy profile of the ligands investigated and suggest that the functional modulation of GPCRs follows structurally well-defined interaction patterns...
  19. pmc Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:29549-62. 2007
    ....
  20. pmc Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial
    Michael E Wechsler
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Lancet 374:1754-64. 2009
    ..We investigated whether there is a genotype-specific response to treatment with a longacting beta2 agonist in combination with inhaled corticosteroid...
  21. doi Observation of "ionic lock" formation in molecular dynamics simulations of wild-type beta 1 and beta 2 adrenergic receptors
    Stefano Vanni
    Laboratory of Computational Chemistry and Biochemistry, Federal Institute of Technology, EPFL, CH 1015 Lausanne, Switzerland
    Biochemistry 48:4789-97. 2009
    ....
  22. ncbi Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy
    Catherine Lavoie
    Centre de Recherche, Institut de Cardiologie de Montreal, Montreal, Quebec, H1T 1C8, Canada
    J Biol Chem 277:35402-10. 2002
    ..Taken together, our data suggest that heterodimerization between beta(1)AR and beta(2)AR inhibits the agonist-promoted internalization of the beta(2)AR and its ability to activate the ERK1/2 MAPK signaling pathway...
  23. pmc Association analyses of adrenergic receptor polymorphisms with obesity and metabolic alterations
    John J Lima
    Pharmacogenetics Center, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Metabolism 56:757-65. 2007
    ..common single nucleotide polymorphisms (SNPs) in beta(1)-adrenergic receptor (ADRB1), beta(2)-adrenergic receptor (ADRB2), beta(3)-adrenergic receptor (ADRB3), and alpha(2)-adrenergic receptor (ADRA2A) genes associate with obesity and ..
  24. pmc beta(1)- and beta(2)-adrenoceptor responses in cardiomyocytes derived from human embryonic stem cells: comparison with failing and non-failing adult human heart
    M Brito-Martins
    National Heart and Lung Institute, Imperial College, London, UK
    Br J Pharmacol 153:751-9. 2008
    ..We have therefore performed detailed pharmacological analysis of the beta-adrenoceptor responses in developing hESC-CM...
  25. ncbi Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors
    M von Zastrow
    Department of Cardiovascular Medicine, Howard Hughes Medical Institute, Stanford Medical Center, California 94305
    J Biol Chem 267:3530-8. 1992
    ....
  26. pmc Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX
    Graham M West
    Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA
    Structure 19:1424-32. 2011
    ....
  27. ncbi Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes
    L M Luttrell
    Howard Hughes Medical Institute and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Science 283:655-61. 1999
    ....
  28. ncbi Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program
    Edwin K Silverman
    Channing Laboratory, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 112:870-6. 2003
    Beta2-adrenergic receptor (B2AR) polymorphisms have been associated with a variety of asthma-related phenotypes, but association results have been inconsistent across different studies.
  29. doi Polymorphism of the ADRB2 gene and response to inhaled beta- agonists in children with asthma: a meta-analysis
    Yaron Finkelstein
    Clinical Pharmacology Unit, and Division of Emergency Medicine, Boston Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    J Asthma 46:900-5. 2009
    ..failure of inhaled beta-agonists is associated with polymorphisms of the beta(2)-adrenergic receptor gene (ADRB2); specifically, mutations leading to amino acid changes at positions 16 and 27, which alter down-regulation of the ..
  30. ncbi Association of codon 16 and codon 27 beta 2-adrenergic receptor gene polymorphisms with obesity: a meta-analysis
    Mihai S Jalba
    Health Services Research Postdoctoral Fellowship Program, Division of Research, Department of Family Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Somerset, New Jersey, USA
    Obesity (Silver Spring) 16:2096-106. 2008
    To search for an association between the Glu27Gln (rs1042714; B27) and the Arg16Gly (rs1042713; B16) polymorphisms of the beta 2-adrenergic receptor (ADRB2) gene and obesity.
  31. ncbi Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma
    Shweta Choudhry
    University of California San Francisco, San Francisco, CA 94143 0833, USA
    Am J Respir Crit Care Med 171:563-70. 2005
    ..We tested the association of beta(2)AR genotypes with asthma severity and bronchodilator response to albuterol in Puerto Ricans and Mexicans with asthma...
  32. pmc β2-adrenergic receptor gene polymorphisms in normal and asthmatic individuals in the Eastern Province of Saudi Arabia
    Abdullah Al-Rubaish
    Department of Internal Medicine, King Fahad Hospital of the University, College of Medicine, University of Dammam, Dammam, Saudi Arabia
    Ann Saudi Med 31:586-90. 2011
    ..Therefore, our main objective was to determine the prevalence of these two mutations among patients with asthma in the Eastern Province and in matched healthy controls...
  33. ncbi Beta(2)-adrenoceptor polymorphism and body mass index are associated with adult-onset asthma in sedentary but not active women
    R G Barr
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 120:1474-9. 2001
    ..In addition, BMI predicts asthma. We hypothesized that these DNA sequence variants predict adult-onset asthma only in sedentary women...
  34. ncbi [Study on beta 2 adrenergic receptor genetic polymorphisms in asthmatics in the people of the Han nationality of northern China]
    G Gao
    Department of Geriatric Respiratory Disease, Chinese PLA General Hospital, Beijing 100853, China
    Zhonghua Jie He He Hu Xi Za Zhi 23:93-7. 2000
    ..To analyze the association between beta 2-AR genetic polymorphism and asthma in the people of the Han nationality of northern China...
  35. ncbi [Association of polymorphism of human beta 2-adrenergic receptor gene and bronchial asthma]
    Jin Ming Gao
    Department of Respiratory Disease, PUMC Hospital, CAMS, PUMC, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 24:626-31. 2002
    ....
  36. ncbi Beta(2)-adrenergic receptor polymorphisms and response to salbutamol among Indian asthmatics*
    Ritushree Kukreti
    GenoMed Lab, Gene Quest Laboratory, Nicholas Piramal India Ltd at Institute of Genomics and Integrative Biology CSIR, Delhi 110007, India ritushree hotmail com
    Pharmacogenomics 6:399-410. 2005
    ....
  37. ncbi [Association between the genetic polymorphisms of beta2-adrenergic receptor gene and the asthma susceptibility and clinical phenotypes in a Chinese population]
    Jin Fu
    Department of Biochemistry and Immunity, Capital Institute of Pediatrics, Beijing, 100020 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:41-5. 2002
    ..To determine whether genetic polymorphisms of beta2-adrenergic receptor gene affect asthma susceptibility and play a role in disease regulation...
  38. ncbi Association of the Gln27Glu polymorphism of the beta-2-adrenergic receptor with preterm labor
    M Ozkur
    Department of Pharmacology, Medical Faculty, Gaziantep University, Turkey
    Int J Gynaecol Obstet 77:209-15. 2002
    To investigate a potential association between the beta-2-adrenergic receptor (B2AR) polymorphisms occurring at amino acid positions 16 (Arg16Gly) and 27 (Gln27Glu) and preterm labor.
  39. ncbi The effect of beta2-adrenoceptor haplotypes on bronchial hyper-responsiveness in patients with asthma
    A M Wilson
    Biomedicine Group, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    Allergy 61:254-9. 2006
    ..The combined effect of these genotypes, or the haplotype, has not been fully characterized in terms of BHR...
  40. pmc Thr164Ile polymorphism of beta2-adrenergic receptor negatively modulates cardiac contractility: implications for prognosis in patients with idiopathic dilated cardiomyopathy
    Emanuele Barbato
    Molecular Biology and Cardiology Unit, Cardiovascular Center and Cardiovascular Research Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    Heart 93:856-61. 2007
    ..However, heart failure is associated with several abnormalities of beta receptor signalling, and underlying mechanisms are not clear...
  41. pmc Probable role of Beta 2-adrenergic receptor gene haplotype in toluene diisocyanate-induced asthma
    Young Min Ye
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea
    Allergy Asthma Immunol Res 2:260-6. 2010
    ..asthma patients (TDI-OA), 60 asymptomatic exposed controls (AEC), and 263 unexposed healthy controls (NC) in order to identify beta 2-adrenergic receptor gene (ADRB2) polymorphisms and the possible association with TDI-induced asthma.
  42. doi Relationship between polymorphisms in the 5' leader cistron, positions 16 and 27 of the adrenergic β2 receptor gene and asthma in a Han population from southwest China
    Wei Ping Fu
    Department of Respiratory Critical Care Medicine, The First Affiliated Hospital of Kunming Medical College, Chinese Academy of Sciences, Kunming, China
    Respirology 16:1221-7. 2011
    Adrenergic β2 receptors (ADRB2) play an important role in regulating pulmonary function...
  43. doi β2-adrenergic receptor haplotype linked to intubation and mechanical ventilation in children with asthma
    Christopher L Carroll
    Department of Pediatrics, Connecticut Children s Medical Center, 282 Washington Street, Hartford, CT 06106, USA
    J Asthma 49:563-8. 2012
    ..However, this has not previously been assessed in this population. We hypothesized that genetic polymorphisms of the β(2)-adrenergic receptor (ADRβ(2)) are associated with intubation and mechanical ventilation in children with asthma...
  44. ncbi The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis
    A L Parola
    Howard Hughes Medical Institute, Stanford University Medical School, California 94305
    J Biol Chem 269:4497-505. 1994
    The 5' leader region of mammalian beta 2 adrenergic receptor messenger RNAs (mRNA) have a short open reading frame (sORF) preceding the receptor cistron...
  45. ncbi Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly
    Susan R Heckbert
    Department of Epidemiology, University of Washington, Seattle, USA
    Circulation 107:2021-4. 2003
    ..We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study...
  46. ncbi beta2-Adrenergic receptor gene variations associated with stage-2 hypertension in northern Han Chinese
    D Ge
    Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China
    Ann Hum Genet 69:36-44. 2005
    ..of this study was to investigate the association between polymorphisms in the beta(2)-adrenergic receptor gene (ADRB2) (-47C/T, Arg16/Gly, Gln27/Glu) and stage-2 hypertension in northern Han Chinese...
  47. ncbi Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study
    S G Terra
    Department of Pharmacy Practice, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
    Int J Obes (Lond) 29:746-54. 2005
    ..is to determine the association between obesity and polymorphisms in genes of the beta(1)AR (ADRB1), beta(2)AR (ADRB2), beta(3)AR (ADRB3), Gs protein alpha (GNAS1), to which all three beta-receptors couple and the G protein beta3 ..
  48. ncbi Beta2-ADR haplotypes/polymorphisms associate with bronchodilator response and total IgE in grass allergy
    G Woszczek
    Department of Clinical Immunology and Allergy, Medical University of Lodz, Lodz, Poland
    Allergy 60:1412-7. 2005
    ..No significant associations were found in regards to asthmatic phenotype and atopy. These results indicate that depending on phenotype studied, either an individual beta2-ADR SNP or beta2-ADR haplotype might affect disease manifestation...
  49. ncbi Impact of variation in ADRB2, ADRB3, and GNB3 genes on body mass index and waist circumference in a Brazilian population
    Vanessa S Mattevi
    Genetics Department, Federal University of Rio Grande do Sul, Porto Alegre, RS, 91501 970, Brazil
    Am J Hum Biol 18:182-6. 2006
    The potential effect of variants in three catecholaminergic pathway genes (ADRB2, ADRB3, and GNB3) on obesity-related traits was investigated in an European-derived Brazilian population...
  50. ncbi Beta2-adrenergic receptor gene polymorphisms and risk of ischemic stroke
    Rosita Stanzione
    Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, University La Sapienza, Rome, Italy
    Am J Hypertens 20:657-62. 2007
    ..Beta2-adrenergic receptors (beta2-AR) mediate vasorelaxation in response to adrenergic agents. Genetic polymorphisms of beta2-AR were implicated in various cardiovascular and noncardiovascular traits...
  51. ncbi Role of ADRB2 gene polymorphism in asthma and response to beta(2)-agonists in Polish children
    A Szczepankiewicz
    Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poland
    J Appl Genet 50:275-81. 2009
    ..aims of this study were: (1) to find associations of asthma with single-nucleotide polymorphisms (SNPs) within the ADRB2 gene: Arg16Gly, Gln27Glu, -1023 G/A, -367 T/C, -47 C/T ; (2) to define linkage disequilibrium in the gene region, ..
  52. pmc Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly in patients with heart failure
    Alfredo Jose Mansur
    Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    BMC Cardiovasc Disord 9:50. 2009
    ..We evaluated these polymorphisms relative to clinical characteristics and prognosis of alarge cohort of patients with heart failure of different etiologies...
  53. pmc Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity
    Dayong Wang
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 407 S Goodwin Ave, Urbana, IL 61801, USA
    FASEB J 24:3511-21. 2010
    ..The present study reveals that non-neurotransmitter Abeta has a binding capacity to beta(2)AR and induces PKA-dependent hyperactivity in AMPA receptors...
  54. pmc Multiple ligand-specific conformations of the β2-adrenergic receptor
    Alem W Kahsai
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Nat Chem Biol 7:692-700. 2011
    ....
  55. pmc Effect of β2-adrenergic receptor gene (ADRB2) 3' untranslated region polymorphisms on inhaled corticosteroid/long-acting β2-adrenergic agonist response
    Helen J Ambrose
    Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC, 27157, USA
    Respir Res 13:37. 2012
    ..in the length of the poly-C repeat in the 3' untranslated region (3'UTR) of the β2-adrenergic receptor gene (ADRB2) may contribute to interindividual variation in β-agonist response...
  56. ncbi Effect of polymorphisms in the β2-adrenergic receptor on the susceptibility and pulmonary function of patients with chronic obstructive pulmonary disease: a meta analysis
    Li Ming Niu
    Department of Respiratory Diseases, Peking University Third Hospital, Beijing 100191, China
    Chin Med J (Engl) 125:2213-8. 2012
    ..However, there was no exclusive conclusion. Therefore, a meta analysis was done to investigate the effect of polymorphisms in the β2-adrenergic receptor (ADRB2) gene on the risk of COPD and lung function.
  57. doi Impact of β(1)- and β(2)-adrenergic receptor gene single nucleotide polymorphisms on heart rate response to metoprolol prior to coronary computed tomographic angiography
    Vlad Cotarlan
    Department of Cardiology, Geisinger Medical Center, Danville, PA, USA
    Am J Cardiol 111:661-6. 2013
    ..In conclusion, these data indicate that the selected SNPs of β(1)-AR and β(2)-AR genes influence HR response to metoprolol in patients who undergo coronary computed tomographic angiography...
  58. doi Association of genetic polymorphisms at beta-adrenergic receptor with risk of intracerebral hemorrhagic stroke in North Indian population: a case control study
    Amit Kumar
    Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
    Neurol India 62:183-8. 2014
    ..Stroke is a multifactorial, polygenic disorder, influenced by both environmental and genetic factors...
  59. ncbi Genetic variation of the beta(2)-adrenoceptor: its functional and clinical importance in bronchial asthma
    D R Taylor
    Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Am J Pharmacogenomics 1:165-74. 2001
    ..not associated with the diagnosis of asthma per se, variant forms of the beta(2)-adrenoceptor (beta2-AR) gene (ADRB2) display functional effects that may be clinically relevant...
  60. ncbi beta2-adrenergic receptor gene single-nucleotide polymorphisms are associated with rheumatoid arthritis in northern Sweden
    B Xu
    Department of Immunology, American Red Cross Biomedical Research and Development, MD 20855, USA
    Scand J Rheumatol 33:395-8. 2004
    ..The gene encoding beta2-AR (ADRB2) displays a moderate degree of heterogeneity in the human population and the distributions of single-nucleotide ..
  61. ncbi Beta 2 adrenergic receptor polymorphisms in cystic fibrosis
    Meeghan A Hart
    Department of Pediatrics, Case Western Reserve University and Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106, USA
    Pediatr Pulmonol 39:544-50. 2005
    ..airway smooth muscle, is the target for inhaled beta agonists, and has several common polymorphisms in its gene, ADRB2. Polymorphisms changing glycine to arginine or glutamate to glutamine in codons 16 and 27, respectively, were ..
  62. pmc Beta-2-adrenergic receptor polymorphisms in cystic fibrosis
    Wendy K Steagall
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1590, USA
    Pharmacogenet Genomics 17:425-30. 2007
    ..Beta-2 adrenergic receptors (beta2AR), which are abundant in airway epithelial cells, accelerate the formation of cyclic adenosine 3', 5' ..
  63. ncbi Polymorphisms of the beta-1 and beta-2 adrenergic receptors in Polish patients with idiopathic dilated cardiomyopathy
    Aleksandra Paczkowska
    Department of Molecular Biology, Institute of Cardiology, Warsaw, Poland
    Kardiol Pol 67:235-41. 2009
    ..The beta-adrenergic receptor pathway is altered in heart failure. Recent studies have discovered functionally relevant and common polymorphisms in both b1-AR and b2-AR...
  64. doi β1, β2, and β3 adrenoceptors and Na+/H+ exchanger regulatory factor 1 expression in human bronchi and their modifications in cystic fibrosis
    Florian Bossard
    INSERM, UMR 915, l institut du thorax, IRT UN, 8 quai Moncousu, Nantes, France
    Am J Respir Cell Mol Biol 44:91-8. 2011
    ..Furthermore, NHERF1 may be a new therapeutic target in patients with CF, to facilitate the trafficking of mutated CFTR to plasma membrane...
  65. pmc Common ADRB2 haplotypes derived from 26 polymorphic sites direct beta2-adrenergic receptor expression and regulation phenotypes
    Alfredo Panebra
    Cardiopulmonary Genomics Program, University of Maryland, Baltimore, Maryland, United States of America
    PLoS ONE 5:e11819. 2010
    The beta2-adrenergic receptor (beta2AR) is expressed on numerous cell-types including airway smooth muscle cells and cardiomyocytes...
  66. ncbi Association between accumulation of visceral fat and the combination of β3 adrenergic receptor Trp64Arg, β2 adrenergic receptor Arg16Gly and uncoupling protein 1 -3826A>G polymorphisms detected by Smart Amplification Process 2
    Katsuhiko Tsunekawa
    Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    Endocr J 58:1079-86. 2011
    ..005). The present study demonstrated the interaction among β3AR Trp64Arg, β2AR Arg16Gly and UCP1 -3826A>G for the accumulation of visceral fat...
  67. doi Identification of novel competing β2AR phospho-extracellular signal regulated kinase 1/2 signaling pathways in human trabecular meshwork cells
    Brian D Hudson
    Department of Pharmacology, Dalhousie University, Halifax, Canada
    J Ocul Pharmacol Ther 28:17-25. 2012
    ..To address this, the current study examined βAR signaling in primary human trabecular meshwork cells (HTMCs), specifically, focusing on the effect of βAR activation on the extracellular signal regulated kinases 1/2 (ERK)...
  68. ncbi Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure
    Pascal de Groote
    Service de Cardiologie C, Hopital Cardiologique, Centre Hospitalier Universitaire de Lille, Lille, France
    Pharmacogenet Genomics 15:137-42. 2005
    ..Heart rate and LVEF responses to beta-blockade were not associated with the beta1AR or the beta2AR polymorphisms...
  69. doi Genetic variation in the autonomic nervous system affects mortality: a study of 1,095 trauma patients
    John A Morris
    Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN, USA
    J Am Coll Surg 208:663-8; discussion 668-70. 2009
    ..We have previously demonstrated an unappreciated link between the autonomic nervous system and mortality, heart rate variability, and physiologic complexity...
  70. ncbi Overexpression of human beta2-adrenergic receptors increases gain of excitation-contraction coupling in mouse ventricular myocytes
    Scott A Grandy
    Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
    Am J Physiol Heart Circ Physiol 287:H1029-38. 2004
    ..Increased gain counteracts the effects of decreased amplitude of I(Ca-L) in voltage-clamped myocytes and likely contributes to increased contraction amplitudes in field-stimulated TG4 myocytes...
  71. ncbi Hypoglycemia-dependent beta2-adrenoceptor downregulation: a contributing factor to hypoglycemia unawareness in patients with Type-1 diabetes?
    K O Schwab
    Department of Pharmacology and Toxicology, University of Wurzburg, Germany
    Horm Res 62:137-41. 2004
    ..75 mmol/l. Beta2-adrenoceptor densities are decreased in patients with subjective hypoglycemia unawareness and might contribute to the reduced beta-adrenergic sensitivity in this subgroup of patients...
  72. ncbi The genetic polymorphisms of beta3-adrenergic receptor (AR) Trp64Arg and beta2-AR Gln27Glu are associated with obesity in Chinese male hypertensive patients
    Wei Mo
    Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Xiang Ya School of Medicine, and Department of Cardiovascular Internal Medicine, Xiang Ya Hospital, Changsha, Hunan, P R China
    Clin Chem Lab Med 45:493-8. 2007
    ..The aims of the present study were to investigate the association between Trp64Arg, Arg16Gly and Gln27Glu polymorphisms and the susceptibility to obesity and hypertension in a Chinese population...
  73. doi The Arg16Gly variant of the beta2-adrenergic receptor predisposes to hypoglycemia unawareness in type 1 diabetes mellitus
    Bas J Schouwenberg
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Pharmacogenet Genomics 18:369-72. 2008
    ..Desensitization of the beta2-adrenergic receptor (ADRB2) is genetically determined by the Arg16Gly variant of this receptor...
  74. pmc A novel protein kinase A-independent, beta-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by beta2-adrenergic receptors
    Kaizheng Gong
    Institute of Vascular Medicine, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China
    J Biol Chem 283:29028-36. 2008
    ....
  75. doi Job stress, gene polymorphism of beta2-AR, and prevalence of hypertension
    Shan fa Yu
    Department of Occupational and Environment Health, School of Public Health, Peking University, Beijing 100083, China
    Biomed Environ Sci 21:239-46. 2008
    ..To study the interactive effect of job stress and genetic susceptibility (or gene polymorphism) on hypertension...
  76. pmc Pharmacogenetic characterization of indacaterol, a novel beta 2-adrenoceptor agonist
    I Sayers
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Br J Pharmacol 158:277-86. 2009
    ..The aim of this study was to investigate the comparative pharmacology of indacaterol in recombinant cells expressing the common polymorphic variants of the human beta(2)-adrenoceptor and in human primary airway smooth muscle (ASM) cells...
  77. doi A46G and C79G polymorphisms in the β2-adrenergic receptor gene (ADRB2) and essential hypertension risk: a meta-analysis
    Yuqing Lou
    Department of Hypertension Research, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, PR China
    Hypertens Res 33:1114-23. 2010
    ..No association could be found in this study between the two polymorphisms and stage 2 hypertension. More studies stratified for different ethnicities and different stages of hypertension should be performed in the future...
  78. ncbi Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2
    Kristina Lorenz
    Institut fur Pharmakologie und Toxikologie, Versbacher Strasse 9, D 97078 Wurzburg, Germany
    Nature 426:574-9. 2003
    ..A physiological role for this mechanism is shown in cardiomyocytes in which the downregulation of RKIP restrains beta-adrenergic signalling and contractile activity...
  79. ncbi Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists
    Gayathri Swaminath
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 157 Beckman Circle, Stanford, CA 94305, USA
    J Biol Chem 280:22165-71. 2005
    ..Moreover, they provide evidence that activation of a GPCR is a multistep process that can be dissected into its component parts using agonist fragments...
  80. ncbi Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer
    Jean Francois Mercier
    Département de Biochimie and Groupe de Recherche sur le Système Nerveux Autonome, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 277:44925-31. 2002
    ....
  81. ncbi Regulation of arrestin-3 phosphorylation by casein kinase II
    You Me Kim
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:16837-46. 2002
    ..Differences between the regulatory roles of arrestin-2 and -3 phosphorylation may contribute to the different cellular functions of these proteins in G protein-coupled receptor signaling and regulation...
  82. pmc beta-Adrenergic receptor polymorphisms and response to salmeterol
    Michael E Wechsler
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    Am J Respir Crit Care Med 173:519-26. 2006
    ..Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists...
  83. pmc Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains
    Kunhong Xiao
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 286:12785-95. 2011
    ....
  84. ncbi Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis
    Maciej Tomaszewski
    British Heart Foundation Blood Pressure Group, Department of Medicine and Therapeutics, University of Glasgow, Glasgow, United Kingdom
    Hypertension 40:286-91. 2002
    ..The detailed analysis of 3 single nucleotide polymorphisms does not support the role of the beta2-adrenergic receptor gene as a major causative gene for the detected linkage...
  85. ncbi Beta2- and beta3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 years
    Kazuko Masuo
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Circulation 111:3429-34. 2005
    ..Functional polymorphisms in the beta2- and beta3-adrenergic receptors have been reported to be associated with hypertension and obesity...
  86. ncbi Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium
    M R Bristow
    Department of Medicine, University of Utah School of Medicine, Salt Lake City 84132
    Mol Pharmacol 35:295-303. 1989
    ....
  87. ncbi The glycine allele of a glycine/arginine polymorphism in the beta2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin
    K Ranade
    Department of Genetics, Stanford University School of Medicine, California, USA
    Am J Hypertens 14:1196-200. 2001
    Several studies implicate polymorphisms in the human beta-adrenergic receptor gene (ADRB2) in the susceptibility to hypertension...
  88. ncbi Association of beta2-adrenoreceptor polymorphisms with nocturnal cough among atopic subjects but not with atopy and nonspecific bronchial hyperresponsiveness
    Sang Hoon Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Allergy Clin Immunol 109:630-5. 2002
    The reports from in vitro studies that beta(2)-adre-nergic receptor (B2AR) polymorphisms are associated with agonist-promoted downregulation have evoked considerable research interest for the roles of these polymorphisms to the ..
  89. ncbi Significance of beta2-adrenergic receptor gene polymorphism in obesity and type 2 diabetes mellitus in Korean subjects
    Sung Hoon Kim
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Metabolism 51:833-7. 2002
    ..The beta(2)-adrenergic receptor (ADRB2) is a major lipolytic receptor in human fat cells, and a recent study has shown that common polymorphisms ..
  90. ncbi Beta(2)-adrenergic receptor lacking the cyclic AMP-dependent protein kinase consensus sites fully activates extracellular signal-regulated kinase 1/2 in human embryonic kidney 293 cells: lack of evidence for G(s)/G(i) switching
    Jacqueline Friedman
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston Medical School, Houston, Texas 77225, USA
    Mol Pharmacol 62:1094-102. 2002
    ....
  91. ncbi Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta2-adrenoceptor polymorphism
    J Alfredo Martinez
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    J Nutr 133:2549-54. 2003
    ..01). This gene-nutrient interaction emphasizes the importance of examining the outcome of some obesity-related mutations depending on lifestyle (including diet) and may explain the heterogeneity of findings from previous studies...
  92. ncbi Beta2 adrenoceptor functional gene variants, obesity, and blood pressure level interactions in the general population
    Alexandre C Pereira
    Laboratory of Genetics and Molecular Cardiology, Heart Institute InCor, Sao Paulo University Medical School, Sao Paulo, SP, Brazil
    Hypertension 42:685-92. 2003
    ..Taken together, these data provide evidence for a strong but complex relation between beta-adrenoceptor gene variants, hypertension, and obesity...
  93. ncbi Beta2-adrenergic receptor gene polymorphisms and pregnancy outcome
    Kunihiko Doh
    Division of Immunology and Infectious Diseases, Weill Medical College of Cornell University, New York, New York 10021, U S A
    J Perinat Med 32:413-7. 2004
    The association between alleles at two loci of the polymorphic beta2-adrenergic receptor (beta2AR) gene and pregnancy outcome was determined.
  94. ncbi Gly16 + Glu27 beta2-adrenoceptor polymorphisms cause increased forearm blood flow responses to mental stress and handgrip in humans
    Ivani C Trombetta
    Heart Institute InCor, Medical School, University of Sao Paulo, Sao Paulo, SP, CEP 05403 000, Brazil
    J Appl Physiol (1985) 98:787-94. 2005
    ..In conclusion, women who are homozygous for Gly(16)/Glu(27) of the beta(2)-adrenoceptors have augmented muscle vasodilatory responsiveness to mental stress and exercise...
  95. ncbi beta(2)-Adrenergic receptor polymorphisms and determinants of cardiovascular risk: the Cardiovascular Health Study
    Lucia A Hindorff
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Am J Hypertens 18:392-7. 2005
    ....
  96. ncbi Association between bronchodilating response to short-acting beta-agonist and non-synonymous single-nucleotide polymorphisms of beta-adrenoceptor gene
    S H Cho
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Clin Exp Allergy 35:1162-7. 2005
    With beta-agonists being the most widely used agents in the treatment of asthma, in vitro studies reported that beta(2)-adrenergic receptor (ADRB2) polymorphisms are associated with agonist-promoted down-regulation.
  97. ncbi Genetic variation associated with preterm birth: a HuGE review
    Krista S Crider
    Division of Birth Defects and Developmental Disabilities, Atlanta, GA 30333, USA
    Genet Med 7:593-604. 2005
    ..This review highlights maternal and fetal genetic susceptibilities to PTB, the potential relationships with environmental risk factors, and the need for additional well-designed studies of this critical public health problem...
  98. ncbi GLU-27 variant of beta2-adrenergic receptor polymorphisms is an independent risk factor for coronary atherosclerotic disease
    Emanuele Barbato
    Cardiovascular Center and Molecular Biology and Cardiology Unit, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    Atherosclerosis 194:e80-6. 2007
    ..Nevertheless, conflicting data have been reported concerning their influence on CAD and cardiovascular clinical events...
  99. pmc beta-2-adrenergic receptor gene polymorphism confers susceptibility to Graves disease
    Krystian Jazdzewski
    Departmrnt of Hypertension and Diabetology, Medical University of Gdansk, Debinki 1, 80 211 Gdansk, Poland
    Int J Mol Med 19:181-6. 2007
    ..The polymorphisms 47A-->G (Arg16Gly) and 79C-->G (Gln27Glu) of the adrenergic beta-2 receptor (ADRB2) gene in the 5q32 region affect the functional reaction to adrenergic stimulation, which contributes to the ..
  100. ncbi Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies
    Eugene R Bleecker
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Lancet 370:2118-25. 2007
    ..that people with asthma who are homozygous for arginine at aminoacid 16 of the beta2-adrenergic receptor (ADRB2) might not benefit from longacting beta2-agonist therapy...
  101. pmc Chromosomal organization of adrenergic receptor genes
    T L Yang-Feng
    Department of Human Genetics, Yale University School of Medicine, New Haven, CT 06510
    Proc Natl Acad Sci U S A 87:1516-20. 1990
    ..The AR genes thus provide a paradigm for understanding the evolution of such structurally conserved yet functionally divergent families of receptor molecules...

Research Grants70

  1. PSYCHONEUROIMMUNOLOGY--MODULATION OF T CELL FUNCTION
    THOMAS ROSZMAN; Fiscal Year: 1999
    ..The proposed studies will focus on defining how stimulation of the beta adrenergic receptor (BAR) alters the activation of T-cells and their subsets by a variety of specific and non- specific stimuli...
  2. IL-1 AND B-ADRENERGIC SYSTEM OF HUMAN AIRWAY EPITHELIUM
    Steven Kelsen; Fiscal Year: 1999
    ..function of the betaAR-AC system of human airway epithelial cells by affecting the expression of the Galphai2 and beta2AR genes; 2) that Galpha i 2, a recently recognized oncogene, drives beta2AR gene expression; and 3) endobronchial ..
  3. PSYCHONEUROIMMUNOLOGY: MODULATION OF T-CELL FUNCTION
    THOMAS ROSZMAN; Fiscal Year: 1993
    ..The proposed studies will focus on defining how stimulation of the beta adrenergic receptor (BAR) alters the activation of T-cells and their subsets by a variety of specific and non- specific stimuli...
  4. Howard A Rockman; Fiscal Year: 2016
    ..However, a number of questions remain: if both b1AR and b2AR bind b-arrestin why is it that only the b1AR activates CaMKII?;and is this selective activation of the b1AR the ..
  5. Beta2-Adrenergic Receptor Gene Variation and Cardiovascular Control in Humans
    John H Eisenach; Fiscal Year: 2012
    ....
  6. Rong Z Gan; Fiscal Year: 2015
    ..tissues between normal and diseased ears in chinchillas using dynamic mechanical analyzer, split Hopkinson tension bar, acoustic driving with laser Doppler vibrometry (LDV), fringe Moiri system, and FE modeling of soft tissue...
  7. SCOTT MCNABB LOUGHHEAD; Fiscal Year: 2014
    ..in a stepwise fashion as a heterogeneous population of cells slowly overcomes the regulatory circuits that normally bar cells from limitless replicative potential. One such regulatory pathway is that of immune surveillance...
  8. An Accurate Mass TOF Mass Spectrometer - HPLC System for Marine Organic Chemistry
    William Fenical; Fiscal Year: 2012
    ..can readily accommodate less than 2 micron particle stationary phases operated at pressures up to 9000 psi (600 bar), which provide for effective and efficient several minute analyses of moderately to highly complex mixtures...
  9. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  10. Impact of 100% Smoke-Free Laws on the Health of Children and Infants
    Dhaval M Dave; Fiscal Year: 2013
    ..on all local and state-level 100% smoke-free legislation by type (workplace, restaurant, and freestanding bar) and other tobacco-control policies to parent and child records from the National Health Interview Surveys (NHIS) ..
  11. Disclosing Contents of Drinks: Experimental Test on Natural Consumption Behavior
    James E Lange; Fiscal Year: 2010
    ..use to monitor their consumption, (b) can motivate them to drink moderately, and (c) could be required within bar and restaurant menus by future policies...
  12. High Throughput Genotyping and DNA Sequencing for Studying the Genetic Contributi
    Sonia Dua; Fiscal Year: 2013
    ..systems shall employ graphical user interfaces through which the contractor shall enter data using direct transfer, bar-code readers, or other automated systems...
  13. Beta-adrenoceptor genetic polymorphisms and obesity
    Julie Johnson; Fiscal Year: 2002
    ..Specifically, we will be studying the association between obesity and genes of the beta1AR (ADRB1), the beta2AR (ADRB2), the beta3AR (ADRB3), the Gs protein alpha subunit (GNAS1) (all three betaARs couple with Gs) and the G ..
  14. Genomic profiling of yeast resistance to AFB1, a P450-activated carcinogen
    MICHAEL THOMAS FASULLO; Fiscal Year: 2013
    ..confer resistance will be identified by high-throughput sensitive assays to measure cell growth and by molecular bar codes using high throughput sequencing or microarrays...
  15. GENETIC ASPECTS OF DNA METHYLATION
    Eric U Selker; Fiscal Year: 2012
    ..We will test all knock-outs for de-repression of our silenced bar gene...
  16. Wade S Kingery; Fiscal Year: 2015
    ..We will test the hypothesis that substance P (SP), calcitonin gene related peptide (CGRP) and beta 2 adrenergic receptor agonists stimulate the production of key inflammasome components, and the activation of caspase-1 ..
  17. Christopher D Gardner; Fiscal Year: 2016
    ..carbohydrates or fats, we identified multi-locus genotype patterns with SNPs from three genes (FABP2, PPARG, and ADRB2): a low carbohydrate-responsive genotype (LCG) and a low fat-responsive genotype (LFG)...
  18. Development of Chemical Chaperonin for Medium Chain Acyl-CoA Dehydrogenase Defici
    AL WALID ABDEL MOHSEN; Fiscal Year: 2010
    ..This provides a much stronger indication of the drugability of the mutant enzyme while providing a higher bar for initial determination of safety of candidate compounds...
  19. Ramen Chmait; Fiscal Year: 2014
    ..Dr. Yaniv Bar-Cohen specializes in pediatric heart rhythm disorders and has expert knowledge of cardiac pacing devices. Dr...
  20. BETA-ADRENERGIC RECEPTOR POLYMORPHISMS AND HYPERTENSION
    Julie Johnson; Fiscal Year: 2003
    ..They will test the hypotheses that the B1AR and/or B2AR genes: 1) are associated with HTN and racial differences in HTN; 2) influence the nocturnal blood pressure (BP) ..
  21. Hiten D Madhani; Fiscal Year: 2016
    ..bombardment methods for gene targeting, our laboratory demonstrated the feasibility of creating large numbers of bar-coded gene deletions in this organism...
  22. JOHANNA K DISTEFANO; Fiscal Year: 2014
    ..The next step will utilize an innovative bar-code approach to next-generation sequencing to fully characterize regions showing association with TC concentration,..
  23. Identification of Antigens for Anti-HIV Broadly Neutralizing Responses
    Steven L Zeichner; Fiscal Year: 2013
    ..In this screen we propose to: 1) Create a library of DNA bar-coded plasmids that include surface expression cassettes capable of placing large amounts of MPER-scaffolding ..
  24. Endothelial BK Channel Regulation by Caveolae Targeting
    Hon Chi Lee; Fiscal Year: 2010
    ..3) beta2-Adrenergic receptors (beta2AR) are targeted to endothelial caveolae and are more efficient than beta1AR in regulating BK channel function...
  25. Virtual screening studies of the Beta-2 Adrenergic Receptor
    Dahlia R Weiss; Fiscal Year: 2012
    ..The B2-adrenergic receptor (B2AR) is responsible for the relaxation of vascular, uterine and airway smooth muscle...
  26. Integrated Desktop Software for Management of Hepatitic C Data
    Johanna C Craig; Fiscal Year: 2010
    ..aim II), and a graphics tool that will present the raw electropherogram data (traces), and assemble line and bar graphs to plot up to two variables (aim III)...
  27. Point-of Care System for Determination of Bilirubin Capacity in Neonates
    GLEN D RAMSAY; Fiscal Year: 2013
    ..electronic design: redesin the electronics to support the hospital information management requirements, such as a bar code reader, printer, and interface with a computer, either directly or via the local internet...
  28. MIM regulates Shh target gene expression in tumors
    SCOTT ATWOOD; Fiscal Year: 2011
    ..We have identified a novel Shh pathway member, Missing in Metastasis (MIM), a BAR-domain protein that regulates membrane dynamics and whose levels are altered in a variety of epithelial cancers and ..
  29. Regulation of Autophagy and Tumorigenesis by Bif-1
    Hong Gang Wang; Fiscal Year: 2013
    ..as SH3GLB1 or endophilin B1, was originally discovered as a Bax-binding protein that contains an amino-terminal N-BAR domain and a carboxy-terminal SH3 domain and demonstrates membrane binding and bending activities...
  30. The Role of the Sympathetic Nervous System in Major Depression and Inflammation
    ANDREA INES LIATIS; Fiscal Year: 2010
    ....
  31. PEDIATRIC PHARMACOLOGY RESEARCH UNIT
    Mary Lieh Lai; Fiscal Year: 2009
    ..6)To determine the role of B2AR gene polymorphism in beta adrenergic response in asthmatic children and to provide a clinical milieu for the ..
  32. Chimeric anti-Methamphetamine Monoclonal Antibody for Treating Stimulant Toxicity
    R BARRY contact HOLTZ; Fiscal Year: 2010
    ..the flux of these drugs into the brain and rendering them inactive without altering the function of any catecholamine receptor, thus providing a unique approach for treating drug abuse...
  33. Defining evolutionary trajectories: Molecular adaptation to antibiotic resistance
    ADIL YOUSIF SHAMOO; Fiscal Year: 2013
    ..turbidostats (fermentors that maintain bacterial populations at their fastest growth rate), genomic sequencing, DNA bar-coding to measure allelic frequencies (FREQ-SEQ), RNA-SEQ and physicochemical characterization, including X-ray ..
  34. Pain Assessment & Intervention Needs (PAIN)
    Fern Fitzhenry; Fiscal Year: 2010
    ..g. bar code medication administration charting and nursing documentation flow sheet charting, can measure the ..
  35. Multiplexed targeting of Pseudomonas aeruginosa essential outer membrane proteins
    Deborah T Hung; Fiscal Year: 2013
    ..We will screen a small molecule library against a pool of bar-coded, genetically engineered target-specific screening strains in which each of the essential OMP genes has been ..
  36. Development of an in vivo screening technology for cancer vaccine immunogens
    Steven L Zeichner; Fiscal Year: 2013
    ..To develop this new screening technology we will: 1) Create a library of bacteria transformed with DNA bar-coded plasmids that include expression cassettes that place large amounts of chimeric protein, which will include ..
  37. Marsha E Bates; Fiscal Year: 2016
    ..clinical scientist addresses this gap by translating a new model of neurocardiac signaling (called the baroreflex [BAR] model) into behavioral interventions for AUDs...
  38. Therapeutic Small Molecule Modulators of G beta gama Signaling
    Val S Goodfellow; Fiscal Year: 2011
    ..adrenergic receptor (BAR) dysfunction represents a hallmark abnormality of heart failure and interference of G-protein mediated GRK2 ..
  39. analysis of srGAP2 in cortical development in vitro and in vivo
    Jaeda Coutinho-Budd; Fiscal Year: 2012
    ..Our preliminary results show that this function is primarily carried out by its N- terminal, membrane-deforming F-BAR domain...
  40. STEVEN ZHAN; Fiscal Year: 2016
    ..Previous studies from our lab and others have shown that MIM belongs to the family of inverse BAR-domain proteins that shapes the membrane curvature and regulates cellular polarity, endocytosis, cell motility and ..
  41. Kimberly C Brouwer; Fiscal Year: 2014
    ..g. street, bar, etc...
  42. Identification of novel genes regulating metalloproteinase activity
    Andreas Herrlich; Fiscal Year: 2009
    ..Infection of a retroviral cDNA library or of a bar-coded shRNAi library, followed by FACS sorting of cells which show altered cleavage ratio allows the identification ..
  43. Quan Lu; Fiscal Year: 2016
    ....
  44. KATHERINE CELINA VARANDAS; Fiscal Year: 2015
    ..MOR), the target for opioid peptides and drugs, and 2) the beta-2-adrenergic receptor (beta-2AR), a catecholamine receptor implicated in reward-based learning...
  45. Yang K Xiang; Fiscal Year: 2014
    ..We will also examine the interactive effects of b1 and b2AR on the spatiotemporal propagation of cAMP signaling. Aim 3...
  46. Origins of Renal Physiology
    Mark L Zeidel; Fiscal Year: 2011
    ..Origins of Renal Physiology, September 3-10, 2011, at the Mount Desert Island Biological Laboratory (MDIBL), in Bar Harbor, Maine...
  47. Rhonda F Souza; Fiscal Year: 2014
    ..Review funding, we addressed this deficiency by establishing cultures of non- neoplastic Barrett's epithelial (BAR-T) cells that we immortalized through the forced expression of telomerase...
  48. ANN FRANCES HAYNOS; Fiscal Year: 2014
    ..Following the intervention, subjects will be given the option to work (by pressing the space bar on a computer task) to either: 1) decrease the number of calories they will be expected to consume, or 2) increase ..
  49. FREDERICK ANTHONY LUZZIO; Fiscal Year: 2016
    ..Our mechanistic characterization of this interaction led to the development of a peptide (designated BAR) that potently inhibits P. gingivalis colonization of the oral cavity...
  50. The F-BAR protein CIP4 in WAS-dependent thrombocytopenia
    SETH JOEL COREY; Fiscal Year: 2012
    ..CIP4 is a member of the F-BAR family of proteins, which remodel the plasma membrane and promote actin polymerization...
  51. DYNAMIC NUCLEAR POLARIZATION SOLID STATE NMR SPECTROMETER FOR BIOMOLECULAR STUDIE
    Ann E McDermott; Fiscal Year: 2010
    ....
  52. HCV diversity and resistance analyzed by DNA bar coding and pyrosequencing
    Gary P Wang; Fiscal Year: 2012
    ..Frederic Bushman, studying the function of lentiviral vectors in gene therapy patients using DMA bar coding and pyrosequencing. Dr...
  53. Xiongwen Chen; Fiscal Year: 2016
    ..effects of PKA and CaMK II signaling and will preserve beneficial effects f SAS signaling through cAMP/EPAC and b2AR/Gi/Akt pathways...
  54. SATHYAMANGLA VENKATA PRASAD; Fiscal Year: 2016
    Beta-adrenergic receptor (bAR) signaling is one of the most powerful regulators of cardiac function...
  55. Anil K Sood; Fiscal Year: 2016
    ..These effects were mediated by the 22-adrenergic receptors (ADRB2) on tumor cells and were blocked by beta-antagonists...
  56. High throughput screening of bacterial collections for surface proteins of commer
    Roy H Hammerstedt; Fiscal Year: 2010
    ..We propose to evaluate this hypothesis using a subset of the PEARL collection, as bar coded bacteria, and immunoglobins [IgG1, IgG3, IgM, IgA] selected because of their medical and commercial ..
  57. Integrated software application for management of Hepatitis C Virus data
    Johanna C Craig; Fiscal Year: 2013
    ..trees and for producing graphics tool that present the raw electropherogram data (traces), and assemble line and bar graphs to plot up to two variables...
  58. Franck Polleux; Fiscal Year: 2016
    ..recent evidence suggests that a new class of molecules directly controlling membrane deformation and dynamics (BAR-like superfamily subdivided into BAR / N-BAR, F-BAR, and I-BAR domains) regulate important cell biological ..
  59. JENNIFER LYNN MUELLER; Fiscal Year: 2014
    ..The algorithms will extract information from EIT images of conductivity and permittivity computed using the D-bar reconstruction algorithm developed by the P.I...
  60. Risk-Informed Interventions in Community Pharmacy: Implementation and Evaluation
    Michael R Cohen; Fiscal Year: 2010
    ..and detection frequency of the intervention;2) Conduct a readiness assessment to prepare for implementation of bar-coding technology in community pharmacies;this study uses a pretest and posttest design to gather self-reported ..
  61. Alan V Smrcka; Fiscal Year: 2016
    ..cardiac calcium-induced calcium release (CICR) and ionotropic responses to [unreadable]-adrenergic receptor (BAR) stimulation...
  62. Lin Gan; Fiscal Year: 2014
    ..Here, we show that in mice lacking BARHL2, a BAR-homeodomain transcription factor, starburst amacrine cells in the ganglion cell layer have aggregated dendrites and ..
  63. JOSEPH B ROGERS; Fiscal Year: 2015
    ..Aim 1 samples, a RainDance enrichment approach will be employed to select for the CR1 genomic region, followed by bar-coded next generation sequencing on the Illumina GA HiSeq instrument...
  64. Blood Brain Barrier Dysfunction in Parkinson's Diseases
    Paul M Carvey; Fiscal Year: 2010
    Convention suggests that the blood brain bar ier (BBB) prevents certain drugs and neurotoxins from gaining access to dopamine (DA) neurons in patients with Parkinson's disease (PD) unless a specific transport mech nism exists...
  65. How Genetic Variation in Protein Kinases Affects Drug Response
    EDWARD E HARLOW; Fiscal Year: 2010
    ..Each clone will sequence verified and uniquely bar-coded. Our second major goal will be to determine how expression of kinases and their variants modify drug response...
  66. Clinical Investigation of Mandibular Implant Overdenture
    David Burns; Fiscal Year: 2005
    ..The project tests three overdenture treatment modalities, (1) four-implant, bar/clip-attached treatment, (2) two-implant, bar/clip-attached treatment, and (3) two-implant independently attached (..
  67. Bar Coding Technology and Patient and Employee Safety
    Ben Tzion Karsh; Fiscal Year: 2006
    b>Bar coding technology and computerized physician order entry (CPOE) are two technologies that have beer heralded as having the potential to substantially curb medication errors (AHRQ 2001)...
  68. ANTIHYPERTENSIVE DRUG/GENE INTERACTIONS AND CV EVENTS
    Bruce Psaty; Fiscal Year: 2004
    ..Secondary aims include other potential gene-drug interactions with the G-protein beta-3 subunit (GB3) polymorphism, B2AR-16 polymorphism, the amiloride-sensitive epithelial sodium channel, and the angiotensinogen Met235Thr polymorphism...
  69. Deregulation of the Ubiquitin/26S Proteasome Pathway in AT cells: Role of ISG15
    SHYAMAL DESAI; Fiscal Year: 2009
    Ataxia Telangiectasia (A-T) (Boder-Sedgwick/Louis-Bar syndrome) is an inherited immunodeficiency disorder with a prevalence of 1 in 30,000-100,000 births...
  70. INTELLIGENT REFRIGERATED AUTOMATIC STORAGE SYSTEM
    DAN CORNELL; Fiscal Year: 1993
    ..will build on the features of the Phase I project: a database to track storage/retrieval/discard of specimens, bar code reading for specimen identification, robotic hardware for movement of specimens...